21915-1-AP

antibody from Proteintech Group

Targeting: OAS3

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

21915-1-AP

Provider

Proteintech Group

Product name

OAS3 antibody

Antibody type

Polyclonal

Description

KD/KO validated OAS3 antibody (Cat. #21915-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

ATG16L1 Regulates Reparative Function of Peritoneal Macrophages During Acute Drug-induced Liver Injury.

Wang X, Zhan X, Gao Y, Wang H, Liu Z, Liu M, Lu L, Zhou H
Cellular and molecular gastroenterology and hepatology 2026;20(2):101674

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Liquid-liquid phase separation mediated immune evasion of respiratory syncytial virus against oligoadenylate synthetase-RNase L pathway.

Hwang WY, Rosenfeld MG, Oh S, Kwon YC
PLoS pathogens 2026 Mar;22(3):e1014089

---

Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity.

Song J, Liu T, Yang J, Zhao L, Su J, Li Z, Ma R, Wen X, Cheng P
Journal of virology 2026 Feb 17;100(2):e0165625

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Role and mechanism of mitochondrial dysfunction‑related gene biomarkers in the progression of type 2 diabetes mellitus.

Liu M, Qiao H
Molecular medicine reports 2025 Jun;31(6)

---

Structural basis for OAS2 regulation and its antiviral function.

Merold V, Bekere I, Kretschmer S, Schnell AF, Kmiec D, Sivarajan R, Lammens K, Liu R, Mergner J, Teppert J, Hirschenberger M, Henrici A, Hammes S, Buder K, Weitz M, Hackmann K, Koenig LM, Pichlmair A, Schwierz N, Sparrer KMJ, Lee-Kirsch MA, de Oliveira Mann CC
Molecular cell 2025 Jun 5;85(11):2176-2193.e13

---

TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.

He J, Kuang Y, Xu K, Huang R, Yang X, Deng L, Feng X, Ren Y, Yang J, Yuan L
Viruses 2025 Jan 30;17(2)

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Activated oligoadenylate synthetase-ribonuclease L pathway promotes endothelial pyroptosis and impairs diabetic wound healing via thioredoxin-interacting protein m(6)A methylation.

Zhou P, Huang Y, Wang Z, Chen D, Long B, Qin P, Li Y, Yang C, Li Q
Molecular biomedicine 2025 Dec 29;6(1):150

---

OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity.

Huai W, Yang K, Xing C, Song K, Lyu H, Williams NS, Wu J, Yan N
Immunity 2025 Apr 8;58(4):797-810.e6

---

RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway.

Yang K, Dong B, Asthana A, Silverman RH, Yan N
The EMBO journal 2024 Sep;43(18):3876-3894

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RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages.

Susanto TT, Hung V, Levine AG, Chen Y, Kerr CH, Yoo Y, Oses-Prieto JA, Fromm L, Zhang Z, Lantz TC, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M
Molecular cell 2024 Sep 19;84(18):3545-3563.e25

---

Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells.

Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Grimaldo-Garcia S, Metzger B, Bolus V, Kopper TJ, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW
Neurology international 2024 Nov 6;16(6):1355-1384

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Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.

De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN
Nature cell biology 2024 Mar;26(3):421-437

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Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer.

Zhang S, Xu X, Zhang K, Lei C, Xu Y, Zhang P, Zhang Y, Gu H, Huang C, Qiu Z
Cancer immunology, immunotherapy : CII 2024 Dec 30;74(1):37

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Artesunate remarkably alleviates interstitial cystitis/bladder pain syndrome in a murine model: Novel molecular signature deciphered by bulk tissue and single-cell transcriptomic analysis.

Wu Y, Shi B, He Y, Wang S, Zhou J, Qi J, Ding J, Wang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 15;38(23):e70225

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A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells.

Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Metzger B, Bolus V, Kopper T, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW
bioRxiv : the preprint server for biology 2024 Apr 12;

---

IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.

Zeng Y, Chen HQ, Zhang Z, Fan J, Li JZ, Zhou SM, Wang N, Yan SP, Cao J, Liu JY, Zhou ZY, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943

---

RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages.

Susanto TT, Hung V, Levine AG, Kerr CH, Yoo Y, Chen Y, Oses-Prieto JA, Fromm L, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M
bioRxiv : the preprint server for biology 2023 Dec 7;

---

Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.

Ke M
Oxidative medicine and cellular longevity 2022;2022:3124122

---

IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway.

Zheng B, Zhou X, Tian L, Wang J, Zhang W
Virologica Sinica 2022 Oct;37(5):676-684

---

OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.

Huang YZ, Zheng YX, Zhou Y, Xu F, Cui YZ, Chen XY, Wang ZY, Yan BX, Zheng M, Man XY
The Journal of investigative dermatology 2022 Oct;142(10):2635-2645.e9

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EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication.

Zhou X, Tian L, Wang J, Zheng B, Zhang W
Virologica Sinica 2022 Jun;37(3):418-426

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Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.

Wei Y, Yang X, Gao L, Yang J, Zheng L, Gao L, Zhou X, Xiang X, Zhang J, Yi C
American journal of cancer research 2021;11(10):4826-4843

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A prenylated dsRNA sensor protects against severe COVID-19.

Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranhão Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G, ISARIC4C Investigators, Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ
Science (New York, N.Y.) 2021 Oct 29;374(6567):eabj3624

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Deficiency of ER Ca(2+) sensor STIM1 in AgRP neurons confers protection against dietary obesity.

Chen Z, Pan S, Yin K, Zhang Y, Yuan X, Wang S, Yang S, Shen Q, Tang Y, Li J, Wang Y, Lu Y, Zhang G
Cell reports 2021 Oct 19;37(3):109868

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Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting.

Liu W, Xie L, He YH, Wu ZY, Liu LX, Bai XF, Deng DX, Xu XE, Liao LD, Lin W, Heng JH, Xu X, Peng L, Huang QF, Li CY, Zhang ZD, Wang W, Zhang GR, Gao X, Wang SH, Li CQ, Xu LY, Liu W, Li EM
Nature communications 2021 Aug 16;12(1):4961

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Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.

Fu Y, Fang Y, Lin Z, Yang L, Zheng L, Hu H, Yu T, Huang B, Chen S, Wang H, Xu S, Bao W, Chen Q, Sun L
iScience 2020 Apr 24;23(4):101026

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

A375 cells were subjected to SDS PAGE followed by western blot with 21915-1-AP(OAS3 antibody) at dilution of 1:800

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The OAS3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human OAS3. This antibody recognizes human antigen. The OAS3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

21915-1-AP.pdf

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