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- Antigen structure
- References [20]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 19279-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19279-1-AP, RRID:AB_10642832
- Product name
- OAS2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OAS2 antibody (Cat. #19279-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
Transcriptome regulation by PARP13 in basal and antiviral states in human cells.
A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells.
Genome-wide DNA methylation sequencing reveals epigenetic features and potential biomarkers of Sjögren syndrome.
IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.
OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.
A prenylated dsRNA sensor protects against severe COVID-19.
OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2).
IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.
Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.
Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.
Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes.
Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection.
Spleen tyrosine kinase (SYK) is a potential target for the treatment of cutaneous lupus erythematosus patients.
Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling.
De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN
Nature cell biology 2024 Mar;26(3):421-437
Nature cell biology 2024 Mar;26(3):421-437
Transcriptome regulation by PARP13 in basal and antiviral states in human cells.
Busa VF, Ando Y, Aigner S, Yee BA, Yeo GW, Leung AKL
iScience 2024 Apr 19;27(4):109251
iScience 2024 Apr 19;27(4):109251
A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells.
Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Metzger B, Bolus V, Kopper T, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW
bioRxiv : the preprint server for biology 2024 Apr 12;
bioRxiv : the preprint server for biology 2024 Apr 12;
Genome-wide DNA methylation sequencing reveals epigenetic features and potential biomarkers of Sjögren syndrome.
Lu DQ, Yao XY, Ren YT, Zhang KY, Zhu XC, Hong T, Yu X, Xie ZM, Chen LY, Wang XC
International journal of rheumatic diseases 2023 Nov;26(11):2223-2232
International journal of rheumatic diseases 2023 Nov;26(11):2223-2232
IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis.
Zeng Y, Chen HQ, Zhang Z, Fan J, Li JZ, Zhou SM, Wang N, Yan SP, Cao J, Liu JY, Zhou ZY, Liu WB
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943
Environmental pollution (Barking, Essex : 1987) 2023 Feb 15;319:120943
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T, Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X, CoV-Contact Cohort§, COVID Human Genetic Effort¶, Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard CL, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL
Science (New York, N.Y.) 2023 Feb 10;379(6632):eabo3627
Science (New York, N.Y.) 2023 Feb 10;379(6632):eabo3627
Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.
Ke M
Oxidative medicine and cellular longevity 2022;2022:3124122
Oxidative medicine and cellular longevity 2022;2022:3124122
OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1‒Induced Jak1‒Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis.
Huang YZ, Zheng YX, Zhou Y, Xu F, Cui YZ, Chen XY, Wang ZY, Yan BX, Zheng M, Man XY
The Journal of investigative dermatology 2022 Oct;142(10):2635-2645.e9
The Journal of investigative dermatology 2022 Oct;142(10):2635-2645.e9
Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.
Lei V, Handfield C, Kwock JT, Kirchner SJ, Lee MJ, Coates M, Wang K, Han Q, Wang Z, Powers JG, Wolfe S, Corcoran DL, Fanelli B, Dadlani M, Ji RR, Zhang JY, MacLeod AS
The Journal of investigative dermatology 2022 Aug;142(8):2249-2259.e9
The Journal of investigative dermatology 2022 Aug;142(8):2249-2259.e9
A prenylated dsRNA sensor protects against severe COVID-19.
Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranhão Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G, ISARIC4C Investigators, Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ
Science (New York, N.Y.) 2021 Oct 29;374(6567):eabj3624
Science (New York, N.Y.) 2021 Oct 29;374(6567):eabj3624
OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.
Boehmer DFR, Formisano S, de Oliveira Mann CC, Mueller SA, Kluge M, Metzger P, Rohlfs M, Hörth C, Kocheise L, Lichtenthaler SF, Hopfner KP, Endres S, Rothenfusser S, Friedel CC, Duewell P, Schnurr M, Koenig LM
Science immunology 2021 Jul 16;6(61)
Science immunology 2021 Jul 16;6(61)
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A
Nature communications 2021 Dec 15;12(1):7310
Nature communications 2021 Dec 15;12(1):7310
Impact of double-stranded RNA characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (OAS2).
Koul A, Deo S, Booy EP, Orriss GL, Genung M, McKenna SA
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Feb;98(1):70-82
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Feb;98(1):70-82
IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.
Kwock JT, Handfield C, Suwanpradid J, Hoang P, McFadden MJ, Labagnara KF, Floyd L, Shannon J, Uppala R, Sarkar MK, Gudjonsson JE, Corcoran DL, Lazear HM, Sempowski G, Horner SM, MacLeod AS
Science advances 2020 Apr;6(14):eaay3245
Science advances 2020 Apr;6(14):eaay3245
Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus.
Benninghoff AD, Bates MA, Chauhan PS, Wierenga KA, Gilley KN, Holian A, Harkema JR, Pestka JJ
Frontiers in immunology 2019;10:2851
Frontiers in immunology 2019;10:2851
Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.
Zhang L, Wang J, Muñoz-Moreno R, Kim M, Sakthivel R, Mo W, Shao D, Anantharaman A, García-Sastre A, Conrad NK, Fontoura BMA
Journal of virology 2018 Dec 15;92(24)
Journal of virology 2018 Dec 15;92(24)
Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes.
Turcatel G, Millette K, Thornton M, Leguizamon S, Grubbs B, Shi W, Warburton D
American journal of physiology. Lung cellular and molecular physiology 2017 Feb 1;312(2):L196-L207
American journal of physiology. Lung cellular and molecular physiology 2017 Feb 1;312(2):L196-L207
Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection.
Li Y, Zhu C, Wang F, Zhu T, Li J, Liu S, Xiao F
Mediators of inflammation 2016;2016:3894816
Mediators of inflammation 2016;2016:3894816
Spleen tyrosine kinase (SYK) is a potential target for the treatment of cutaneous lupus erythematosus patients.
Braegelmann C, Hölzel M, Ludbrook V, Dickson M, Turan N, Ferring-Schmitt S, Sternberg S, Bieber T, Kuhn A, Wenzel J
Experimental dermatology 2016 May;25(5):375-9
Experimental dermatology 2016 May;25(5):375-9
Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling.
Grammatikos AP, Ghosh D, Devlin A, Kyttaris VC, Tsokos GC
PloS one 2013;8(8):e74550
PloS one 2013;8(8):e74550
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 19279-1-AP(OAS2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using OAS2 antibody 19279-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 19279-1-AP(OAS2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 19279-1-AP(OAS2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
