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- Antigen structure
- References [28]
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- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 13474-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13474-1-AP, RRID:AB_10697652
- Product name
- Cryptochrome 1 antibody
- Antibody type
- Polyclonal
- Description
- Cryptochrome 1 antibody (Cat. #13474-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Decreased Memory and Learning Ability Mediated by Bmal1/M1 Macrophages/Angptl2/Inflammatory Cytokine Pathway in Mice Exposed to Long-Term Blue Light Irradiation.
Alleviative effects of the parthenolide derivative ACT001 on insulin resistance induced by sodium propionate combined with a high-fat diet and its potential mechanisms.
Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy.
Chronotoxici-Plate Containing Droplet-Engineered Rhythmic Liver Organoids for Drug Toxicity Evaluation.
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet.
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.
CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.
Maternal circadian disruption before pregnancy impairs the ovarian function of female offspring in mice.
Circadian clocks are modulated by compartmentalized oscillating translation.
Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium.
Interaction of Bmal1 and eIF2α/ATF4 pathway was involved in Shuxie compound alleviation of circadian rhythm disturbance-induced hepatic endoplasmic reticulum stress.
Acute hypoxia induced dysregulation of clock-controlled ovary functions.
Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model.
Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats.
Melatonin regulates the immune response and improves Sjögren's syndrome-like symptoms in NOD/Ltj Mice.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise.
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes.
Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway.
Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats.
SCA1(+) Cells from the Heart Possess a Molecular Circadian Clock and Display Circadian Oscillations in Cellular Functions.
Circadian networks in human embryonic stem cell-derived cardiomyocytes.
Effect of Jiaotai Pill () on intestinal damage in partially sleep deprived rats.
Rhythmic expression of miR-27b-3p targets the clock gene Bmal1 at the posttranscriptional level in the mouse liver.
Hiramoto K, Kubo S, Tsuji K, Sugiyama D, Hamano H
Current issues in molecular biology 2024 May 18;46(5):4924-4934
Current issues in molecular biology 2024 May 18;46(5):4924-4934
Alleviative effects of the parthenolide derivative ACT001 on insulin resistance induced by sodium propionate combined with a high-fat diet and its potential mechanisms.
Yu Q, Zuo X, Bai H, Zhang S, Luan J, Zhao Q, Zhao X, Feng X
European journal of pharmacology 2024 May 15;971:176529
European journal of pharmacology 2024 May 15;971:176529
Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy.
Ma J, Chen S, Liu J, Liao Y, Li L, Wang CC, Song S, Feng R, Hu H, Quan S
Free radical biology & medicine 2024 May 1;217:1-14
Free radical biology & medicine 2024 May 1;217:1-14
Chronotoxici-Plate Containing Droplet-Engineered Rhythmic Liver Organoids for Drug Toxicity Evaluation.
Zhou J, Huang YC, Wang W, Li J, Hou Y, Yi Z, Yang H, Hu K, Zhu Y, Wang Z, Ma S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2305925
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2305925
Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet.
Li R, Wang G, Liu R, Luo L, Zhang Y, Wan Z
Journal of physiology and biochemistry 2024 Feb;80(1):137-147
Journal of physiology and biochemistry 2024 Feb;80(1):137-147
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
Fangninou FF, Yu Z, Li W, Xue L, Yin D
The Science of the total environment 2024 Feb 20;912:169305
The Science of the total environment 2024 Feb 20;912:169305
Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization.
Yao D, Li R, Hao J, Huang H, Wang X, Ran L, Fang Y, He Y, Wang W, Liu X, Wang M
Translational psychiatry 2023 Oct 6;13(1):310
Translational psychiatry 2023 Oct 6;13(1):310
CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Lin L, Huang Y, Wang J, Guo X, Yu F, He D, Wu C, Guo L, Wu B
Biochemical pharmacology 2023 Nov;217:115843
Biochemical pharmacology 2023 Nov;217:115843
Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.
Hammarlund JA, Li SY, Wu G, Lian JW, Howell SJ, Clarke R, Adamson A, Gonçalves CF, Hogenesch JB, Meng QJ, Anafi RC
bioRxiv : the preprint server for biology 2023 May 19;
bioRxiv : the preprint server for biology 2023 May 19;
Maternal circadian disruption before pregnancy impairs the ovarian function of female offspring in mice.
Guan Y, Xu M, Zhang Z, Liu C, Zhou J, Lin F, Fang J, Zhang Y, Yue Q, Zhen X, Yan G, Sun H, Liu W
The Science of the total environment 2023 Mar 15;864:161161
The Science of the total environment 2023 Mar 15;864:161161
Circadian clocks are modulated by compartmentalized oscillating translation.
Zhuang Y, Li Z, Xiong S, Sun C, Li B, Wu SA, Lyu J, Shi X, Yang L, Chen Y, Bao Z, Li X, Sun C, Chen Y, Deng H, Li T, Wu Q, Qi L, Huang Y, Yang X, Lin Y
Cell 2023 Jul 20;186(15):3245-3260.e23
Cell 2023 Jul 20;186(15):3245-3260.e23
Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium.
Dulko E, Jedrusiak M, Osuru HP, Atluri N, Illendula M, Davis EM, Beenhakker MP, Lunardi N
Anesthesia and analgesia 2023 Jul 1;137(1):209-220
Anesthesia and analgesia 2023 Jul 1;137(1):209-220
Interaction of Bmal1 and eIF2α/ATF4 pathway was involved in Shuxie compound alleviation of circadian rhythm disturbance-induced hepatic endoplasmic reticulum stress.
Zhang M, Wu W, Huang C, Cai T, Wang M, Zhao N, Liu S, Yang S
Journal of ethnopharmacology 2023 Aug 10;312:116446
Journal of ethnopharmacology 2023 Aug 10;312:116446
Acute hypoxia induced dysregulation of clock-controlled ovary functions.
Ding M, Lu Y, Huang X, Xing C, Hou S, Wang D, Zhang Y, Wang W, Zhang C, Zhang M, Meng F, Liu K, Liu G, Zhao J, Song L
Frontiers in physiology 2022;13:1024038
Frontiers in physiology 2022;13:1024038
Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model.
Naven MA, Zeef LAH, Li S, Humphreys PA, Smith CA, Pathiranage D, Cain S, Woods S, Bates N, Au M, Wen C, Kimber SJ, Meng QJ
Theranostics 2022;12(8):3963-3976
Theranostics 2022;12(8):3963-3976
Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats.
Song X, Zhao M, Tang J, Ma T, Bai H, Wang X, Liu L, Li T, Xu X, Sheng X, Zhao B, Wang Y, Wang T, Guo Y, Zhang X, Gao L
Arthritis research & therapy 2022 Jun 28;24(1):158
Arthritis research & therapy 2022 Jun 28;24(1):158
Melatonin regulates the immune response and improves Sjögren's syndrome-like symptoms in NOD/Ltj Mice.
Liu Y, Weng X, Wei M, Yu S, Ding Y, Cheng B
Biochemical pharmacology 2022 Jul;201:115073
Biochemical pharmacology 2022 Jul;201:115073
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise.
Luo L, Li R, Wang G, Chen J, Chen L, Qin LQ, Yu Z, Wan Z
Food & function 2022 Apr 20;13(8):4445-4458
Food & function 2022 Apr 20;13(8):4445-4458
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Wan X, Zhu L, Zhao L, Peng L, Xiong J, Yang W, Yuan J, Liang F, Zhang K, Chen K
Cell death & disease 2021 Mar 19;12(4):301
Cell death & disease 2021 Mar 19;12(4):301
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy.
Wu H, Liu Y, Liu L, Meng Q, Du C, Li K, Dong S, Zhang Y, Li H, Zhang H
Molecular brain 2021 Jul 14;14(1):113
Molecular brain 2021 Jul 14;14(1):113
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes.
Jiang Y, Gu Y, Xu H, Tian X, Zhang X, Xu X, Yan W, Zhang X
BMC molecular and cell biology 2020 Jun 19;21(1):44
BMC molecular and cell biology 2020 Jun 19;21(1):44
Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway.
Ji G, Lv K, Chen H, Wang Y, Zhang Y, Li Y, Qu L
Free radical biology & medicine 2019 Dec;145:312-320
Free radical biology & medicine 2019 Dec;145:312-320
Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats.
Huang WY, Zou X, Lu FE, Su H, Zhang C, Ren YL, Fang K, Xu LJ, Wang KF, Chen QJ, Dong H
Current medical science 2018 Aug;38(4):704-713
Current medical science 2018 Aug;38(4):704-713
SCA1(+) Cells from the Heart Possess a Molecular Circadian Clock and Display Circadian Oscillations in Cellular Functions.
Du Pré BC, Demkes EJ, Feyen DAM, Dierickx P, Crnko S, Kok BJM, Sluijter JPG, Doevendans PA, Vos MA, Van Veen TAB, Van Laake LW
Stem cell reports 2017 Sep 12;9(3):762-769
Stem cell reports 2017 Sep 12;9(3):762-769
Circadian networks in human embryonic stem cell-derived cardiomyocytes.
Dierickx P, Vermunt MW, Muraro MJ, Creyghton MP, Doevendans PA, van Oudenaarden A, Geijsen N, Van Laake LW
EMBO reports 2017 Jul;18(7):1199-1212
EMBO reports 2017 Jul;18(7):1199-1212
Effect of Jiaotai Pill () on intestinal damage in partially sleep deprived rats.
Huang WY, Zou X, Lu FE, Zhang C, Ren YL, Xu LJ, Wang KF, Dong H
Chinese journal of integrative medicine 2017 Dec;23(12):901-907
Chinese journal of integrative medicine 2017 Dec;23(12):901-907
Rhythmic expression of miR-27b-3p targets the clock gene Bmal1 at the posttranscriptional level in the mouse liver.
Zhang W, Wang P, Chen S, Zhang Z, Liang T, Liu C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Jun;30(6):2151-60
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Jun;30(6):2151-60
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Y79 cells were subjected to SDS PAGE followed by western blot with 13474-1-AP(CRY1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using CRY1 antibody 13474-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
