MA5-15108

antibody from Invitrogen Antibodies

Targeting: MAPT DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau

Western blot (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Other assay (Supportive data in Antibodypedia)

Antibody Data

Product number

MA5-15108

Provider

Invitrogen Antibodies

Product name

Tau Monoclonal Antibody (S.125.0)

Antibody type

Monoclonal

Antigen

Other

Description

It is not recommended to aliquot this antibody.

Reactivity

Human, Mouse, Rat

Host

Mouse

Isotype

IgG

Antibody clone number

S.125.0

Vial size

100 μL

Concentration

646 μg/mL

Storage

-20°C

References

Submitted references

Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.

Guarascio R, Salih D, Yasvoina M, Edwards FA, Cheetham ME, van der Spuy J
Human molecular genetics 2020 Jan 1;29(1):80-96

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Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells.

Begum AN, Aguilar JS, Elias L, Hong Y
Neurotoxicology 2016 Dec;57:45-53

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HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.

Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma H, Tamura T, Watanabe H, Katsuno M, Matsumi C, Kajikawa M, Saito T, Saido T, Sobue G, Miyawaki A, Okazawa H
Scientific reports 2016 Aug 25;6:31895

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LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro.

Fu ZQ, Yang Y, Song J, Jiang Q, Lin ZC, Wang Q, Zhu LQ, Wang JZ, Tian Q
Journal of Alzheimer's disease : JAD 2010;21(4):1107-17

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LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro.

Fu ZQ, Yang Y, Song J, Jiang Q, Lin ZC, Wang Q, Zhu LQ, Wang JZ, Tian Q
Journal of Alzheimer's disease : JAD 2010;21(4):1107-17

Immunocytochemistry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Immunofluorescent analysis of Tau in mouse dentate gyrus using a Tau monoclonal antibody (Product # MA5-15108) (red) and a CREB monoclonal antibody (blue).

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Immunofluorescent analysis of Tau in human Alzheimer brain using a Tau monoclonal antibody (Product # MA5-15108) (green) and an APP antibody (red).

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Immunofluorescent analysis of Tau using a monoclonal antibody (Product # MA5-15108).

Other assay

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Figure 2 Ser46 phosphorylation of MARCKS is a marker of degenerative neurites. (a) Anti-pMARCKS (Ser46)-stained amyloid plaque-like structures in the cerebrum of 5xFAD mice but not in wild type B6/SJL mice. The synthetic peptide ENGHVKVNGDA(pS)PA was used for antigen absorption. (b) Three-dimensional reconstruction of Abeta (green), Ser46-pMARCKS (red), and DAPI (blue) co-staining revealed that Ser46-phosphorylated MARCKS surrounds amyloid aggregates after cell death. The corresponding movie is attached as Supplementary Information . (c) Three-dimensional reconstruction of Abeta (green), Ser46-pMARCKS (red), and DAPI (blue) revealed similar patterns in human AD brains. (d) Three-dimensional reconstruction of tau (green), Ser46-pMARCKS (red), and DAPI (blue) revealed that Ser46-phosphorylation of MARCKS occurs in the axons of human AD brains.