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antibody from Invitrogen Antibodies
Targeting: MAPT
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
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- Antibody Data
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- References [450]
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- Product number
- MN1020B - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AT8), Biotin
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MN1020B targets PHF-tau (Ser202/Thr205) in IF, ELISA, and IHC (P) applications and shows reactivity with Human samples.
- Conjugate
- Biotin
- Antibody clone number
- AT8
- Concentration
- 0.1 mg/mL
Submitted references Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration.
APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model.
Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.
Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer's Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques.
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease.
Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets.
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
Activated microglia mitigate Aβ-associated tau seeding and spreading.
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology.
Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease.
Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients.
NLRP3 inflammasome activation drives tau pathology.
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways.
TREM2 function impedes tau seeding in neuritic plaques.
Distribution of endogenous normal tau in the mouse brain.
Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Neurodegeneration Enhances the Development of Arthritis.
BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR.
NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.
Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism.
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy.
Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile.
Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes.
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Expanding the spectrum of neuronal pathology in multiple system atrophy.
S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.
Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats.
Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.
Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.
Distribution of pathology in frontal variant Alzheimer's disease.
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.
Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.
Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.
Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.
Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Visualizing the microtubule-associated protein tau in the nucleus.
Ubiquilin 2 is not associated with tau pathology.
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
PINCH in the cellular stress response to tau-hyperphosphorylation.
Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease.
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage.
SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.
A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease.
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system.
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.
Making the diagnosis of frontotemporal lobar degeneration.
Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
Clinical correlates in an experimental model of repetitive mild brain injury.
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.
Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.
Age-related loss of noradrenergic neurons in the brains of triple transgenic mice.
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration.
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance.
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.
NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.
Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.
Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.
High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.
Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy.
Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia.
STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.
Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway.
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Antemortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies.
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.
Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.
Asymmetry of neurodegenerative disease-related pathologies: a cautionary note.
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts.
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
First transgenic rat model developing progressive cortical neurofibrillary tangles.
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology.
Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology.
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.
Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.
Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.
(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains.
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer's disease.
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.
Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice.
Cerebral amyloid β(42) deposits and microvascular pathology in ageing baboons.
Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters.
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
Hirano body-rich subtypes of Creutzfeldt-Jakob disease.
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.
"Preclinical" MSA in definite Creutzfeldt-Jakob disease.
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
Frontal cortex neuropathology in dementia pugilistica.
Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes.
Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway.
A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death.
Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene.
Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
Microglial pathology in Down syndrome.
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.
ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases.
Fronto-temporal lobar degeneration: neuropathology in 60 cases.
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.
Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Rapidly progressive diffuse Lewy body disease.
ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia.
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension.
Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease.
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.
Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases.
Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.
Protein aggregation in the aging retina.
WNT signaling in activated microglia is proinflammatory.
Propofol directly increases tau phosphorylation.
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation.
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.
Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.
Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.
The pathological process underlying Alzheimer's disease in individuals under thirty.
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510).
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice.
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors.
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
αB-crystallin negative astrocytic inclusions.
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Influence of water quality on cholesterol-induced tau pathology: preliminary data.
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease.
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation.
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.
Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease.
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
Regulation of tau pathology by the microglial fractalkine receptor.
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease.
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.
Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.
Acute hypoxia promote the phosphorylation of tau via ERK pathway.
Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.
Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy.
Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.
Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker.
Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord.
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity.
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease.
In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.
Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.
Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5.
Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.
Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.
Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.
DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease.
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.
Isolated bulbar paralysis in a patient with medullar tau pathology: a case report.
Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models.
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi.
Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.
Caspase activation precedes and leads to tangles.
Hyposmia in progressive supranuclear palsy.
Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases.
Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.
Altered subcellular distribution of c-Abl in Alzheimer's disease.
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration.
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.
Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Transmission and spreading of tauopathy in transgenic mouse brain.
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau.
Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.
Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.
The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Rapidly progressive neurodegenerative dementias.
Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease.
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels.
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Age and apoE associations with complex pathologic features in Alzheimer's disease.
Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice.
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation.
Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease.
A new function of microtubule-associated protein tau: involvement in chromosome stability.
A new function of microtubule-associated protein tau: involvement in chromosome stability.
ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation.
MAPT S305I mutation: implications for argyrophilic grain disease.
Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
Beta-amyloid burden is not associated with rates of brain atrophy.
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.
Argyrophilic grains: a distinct disease or an additive pathology?
Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice.
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia.
Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline.
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology.
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.
Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors.
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.
Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
Insular pathology in Parkinson's disease patients with orthostatic hypotension.
Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.
Inflammatory changes parallel the early stages of Alzheimer disease.
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Rates of cerebral atrophy differ in different degenerative pathologies.
Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia.
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.
Cognitive impairment and celiac disease.
Tau interacts with Golgi membranes and mediates their association with microtubules.
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Memory complaints are related to Alzheimer disease pathology in older persons.
Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.
Neuropathologic features of amnestic mild cognitive impairment.
Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations.
Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension.
A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.
Neuropathology in the S305S tau gene mutation.
Interleukin-1 mediates Alzheimer and Lewy body pathologies.
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment.
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits.
High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus.
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.
Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation.
A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates.
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.
Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons.
Antemortem diagnosis of frontotemporal lobar degeneration.
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease.
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Neuropathology of cognitively normal elderly.
Neuropathology of cognitively normal elderly.
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex.
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments.
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes.
Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T
The Journal of experimental medicine 2022 Mar 7;219(3)
The Journal of experimental medicine 2022 Mar 7;219(3)
APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model.
Gratuze M, Jiang H, Wang C, Xiong M, Bao X, Holtzman DM
Annals of neurology 2022 Jun;91(6):847-852
Annals of neurology 2022 Jun;91(6):847-852
Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.
McKee CA, Lee J, Cai Y, Saito T, Saido T, Musiek ES
Scientific reports 2022 Feb 2;12(1):1796
Scientific reports 2022 Feb 2;12(1):1796
Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer's Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques.
Su D, Chai Y, Yang J, Wang X, Liu Y, Ma J, Tang X, Mishra C, Chandra SR, Yue W, Ai J
Frontiers in pharmacology 2021;12:633805
Frontiers in pharmacology 2021;12:633805
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Nies SH, Takahashi H, Herber CS, Huttner A, Chase A, Strittmatter SM
The Journal of biological chemistry 2021 Oct;297(4):101159
The Journal of biological chemistry 2021 Oct;297(4):101159
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model.
Litvinchuk A, Huynh TV, Shi Y, Jackson RJ, Finn MB, Manis M, Francis CM, Tran AC, Sullivan PM, Ulrich JD, Hyman BT, Cole T, Holtzman DM
Annals of neurology 2021 May;89(5):952-966
Annals of neurology 2021 May;89(5):952-966
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS, Manis M, Schroeder C, Yin Z, Madore C, Butovsky O, Artyomov M, Ulrich JD, Holtzman DM
Neuron 2021 May 19;109(10):1657-1674.e7
Neuron 2021 May 19;109(10):1657-1674.e7
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Dong Y, Liang F, Huang L, Fang F, Yang G, Tanzi RE, Zhang Y, Quan Q, Xie Z
Communications biology 2021 May 12;4(1):560
Communications biology 2021 May 12;4(1):560
Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease.
York A, Everhart A, Vitek MP, Gottschalk KW, Colton CA
ASN neuro 2021 Jan-Dec;13:17590914211019443
ASN neuro 2021 Jan-Dec;13:17590914211019443
Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets.
Schwerin SC, Chatterjee M, Hutchinson EB, Djankpa FT, Armstrong RC, McCabe JT, Perl DP, Juliano SL
Journal of neuropathology and experimental neurology 2021 Jan 20;80(2):112-128
Journal of neuropathology and experimental neurology 2021 Jan 20;80(2):112-128
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC
The Journal of clinical investigation 2021 Feb 15;131(4)
The Journal of clinical investigation 2021 Feb 15;131(4)
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, Woost B, Bennett RE, Orr TC, Zhou Y, Andhey PS, Colonna M, Sudmant PH, Xu P, Wang M, Zhang B, Zare H, Orr ME
Nature aging 2021 Dec;1(12):1107-1116
Nature aging 2021 Dec;1(12):1107-1116
Activated microglia mitigate Aβ-associated tau seeding and spreading.
Gratuze M, Chen Y, Parhizkar S, Jain N, Strickland MR, Serrano JR, Colonna M, Ulrich JD, Holtzman DM
The Journal of experimental medicine 2021 Aug 2;218(8)
The Journal of experimental medicine 2021 Aug 2;218(8)
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
Gratuze M, Leyns CE, Sauerbeck AD, St-Pierre MK, Xiong M, Kim N, Serrano JR, Tremblay MÈ, Kummer TT, Colonna M, Ulrich JD, Holtzman DM
The Journal of clinical investigation 2020 Sep 1;130(9):4954-4968
The Journal of clinical investigation 2020 Sep 1;130(9):4954-4968
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology.
Laversenne V, Nazeeruddin S, Källstig EC, Colin P, Voize C, Schneider BL
Acta neuropathologica communications 2020 Nov 23;8(1):198
Acta neuropathologica communications 2020 Nov 23;8(1):198
Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease.
Guillemaud O, Ceyzériat K, Saint-Georges T, Cambon K, Petit F, Ben Haim L, Carrillo-de Sauvage MA, Guillermier M, Bernier S, Hérard AS, Joséphine C, Bémelmans AP, Brouillet E, Hantraye P, Bonvento G, Escartin C
Neurobiology of aging 2020 Jun;90:135-146
Neurobiology of aging 2020 Jun;90:135-146
Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients.
Metaxas A, Thygesen C, Briting SRR, Landau AM, Darvesh S, Finsen B
Frontiers in cellular neuroscience 2019;13:538
Frontiers in cellular neuroscience 2019;13:538
NLRP3 inflammasome activation drives tau pathology.
Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT
Nature 2019 Nov;575(7784):669-673
Nature 2019 Nov;575(7784):669-673
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
Shi Y, Manis M, Long J, Wang K, Sullivan PM, Remolina Serrano J, Hoyle R, Holtzman DM
The Journal of experimental medicine 2019 Nov 4;216(11):2546-2561
The Journal of experimental medicine 2019 Nov 4;216(11):2546-2561
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J
Science advances 2019 Jan;5(1):eaau3333
Science advances 2019 Jan;5(1):eaau3333
Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways.
Christensen KR, Beach TG, Serrano GE, Kanaan NM
Acta neuropathologica communications 2019 Feb 28;7(1):29
Acta neuropathologica communications 2019 Feb 28;7(1):29
TREM2 function impedes tau seeding in neuritic plaques.
Leyns CEG, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM
Nature neuroscience 2019 Aug;22(8):1217-1222
Nature neuroscience 2019 Aug;22(8):1217-1222
Distribution of endogenous normal tau in the mouse brain.
Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M, Murayama S, Ihara Y, Miyasaka T
The Journal of comparative neurology 2019 Apr 1;527(5):985-998
The Journal of comparative neurology 2019 Apr 1;527(5):985-998
Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system.
Murphy K, Llewellyn K, Wakser S, Pontasch J, Samanich N, Flemer M, Hensley K, Kim DS, Park J
The Journal of biological chemistry 2018 Nov 23;293(47):18242-18269
The Journal of biological chemistry 2018 Nov 23;293(47):18242-18269
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C, Alzheimer’s Disease Neuroimaging Initiative, Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM
Nature 2017 Sep 28;549(7673):523-527
Nature 2017 Sep 28;549(7673):523-527
Neurodegeneration Enhances the Development of Arthritis.
Lang SC, Harre U, Purohit P, Dietel K, Kienhöfer D, Hahn J, Baum W, Herrmann M, Schett G, Mielenz D
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2394-2402
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2394-2402
BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR.
Makani V, Jang YG, Christopher K, Judy W, Eckstein J, Hensley K, Chiaia N, Kim DS, Park J
PloS one 2016;11(3):e0149715
PloS one 2016;11(3):e0149715
NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.
Levenson JM, Schroeter S, Carroll JC, Cullen V, Asp E, Proschitsky M, Chung CH, Gilead S, Nadeem M, Dodiya HB, Shoaga S, Mufson EJ, Tsubery H, Krishnan R, Wright J, Solomon B, Fisher R, Gannon KS
Alzheimer's & dementia (New York, N. Y.) 2016 Sep;2(3):141-155
Alzheimer's & dementia (New York, N. Y.) 2016 Sep;2(3):141-155
Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism.
Foxton R, Osborne A, Martin KR, Ng YS, Shima DT
Cell death & disease 2016 May 5;7(5):e2212
Cell death & disease 2016 May 5;7(5):e2212
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy.
Puvenna V, Engeler M, Banjara M, Brennan C, Schreiber P, Dadas A, Bahrami A, Solanki J, Bandyopadhyay A, Morris JK, Bernick C, Ghosh C, Rapp E, Bazarian JJ, Janigro D
Brain research 2016 Jan 1;1630:225-40
Brain research 2016 Jan 1;1630:225-40
Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile.
Liu P, Paulson JB, Forster CL, Shapiro SL, Ashe KH, Zahs KR
PloS one 2015;10(5):e0126317
PloS one 2015;10(5):e0126317
Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes.
Tousseyn T, Bajsarowicz K, Sánchez H, Gheyara A, Oehler A, Geschwind M, DeArmond B, DeArmond SJ
Journal of neuropathology and experimental neurology 2015 Sep;74(9):873-88
Journal of neuropathology and experimental neurology 2015 Sep;74(9):873-88
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT
Nature communications 2015 Oct 13;6:8490
Nature communications 2015 Oct 13;6:8490
Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF
Human molecular genetics 2015 Jan 1;24(1):76-85
Human molecular genetics 2015 Jan 1;24(1):76-85
Expanding the spectrum of neuronal pathology in multiple system atrophy.
Cykowski MD, Coon EA, Powell SZ, Jenkins SM, Benarroch EE, Low PA, Schmeichel AM, Parisi JE
Brain : a journal of neurology 2015 Aug;138(Pt 8):2293-309
Brain : a journal of neurology 2015 Aug;138(Pt 8):2293-309
S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.
Kim HJ, Chang KA, Ha TY, Kim J, Ha S, Shin KY, Moon C, Nacken W, Kim HS, Suh YH
PloS one 2014;9(2):e88924
PloS one 2014;9(2):e88924
Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats.
Lin L, Yang SS, Chu J, Wang L, Ning LN, Zhang T, Jiang Q, Tian Q, Wang JZ
Journal of Alzheimer's disease : JAD 2014;41(4):1149-63
Journal of Alzheimer's disease : JAD 2014;41(4):1149-63
Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.
Dalby NO, Volbracht C, Helboe L, Larsen PH, Jensen HS, Egebjerg J, Elvang AB
Journal of Alzheimer's disease : JAD 2014;40(2):429-42
Journal of Alzheimer's disease : JAD 2014;40(2):429-42
Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.
Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Sogabe T, Tooyama I
Journal of Alzheimer's disease : JAD 2014;39(3):617-31
Journal of Alzheimer's disease : JAD 2014;39(3):617-31
Distribution of pathology in frontal variant Alzheimer's disease.
Blennerhassett R, Lillo P, Halliday GM, Hodges JR, Kril JJ
Journal of Alzheimer's disease : JAD 2014;39(1):63-70
Journal of Alzheimer's disease : JAD 2014;39(1):63-70
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Jiang T, Yu JT, Zhu XC, Zhang QQ, Cao L, Wang HF, Tan MS, Gao Q, Qin H, Zhang YD, Tan L
Neuropharmacology 2014 Oct;85:121-30
Neuropharmacology 2014 Oct;85:121-30
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
Huang XT, Qian ZM, He X, Gong Q, Wu KC, Jiang LR, Lu LN, Zhu ZJ, Zhang HY, Yung WH, Ke Y
Neurobiology of aging 2014 May;35(5):1045-54
Neurobiology of aging 2014 May;35(5):1045-54
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, Fukuda Y, Nakai Y, Uchida T, Sato E, Tanemura K
FEBS letters 2014 May 29;588(11):2003-8
FEBS letters 2014 May 29;588(11):2003-8
The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.
Lasagna-Reeves CA, Sengupta U, Castillo-Carranza D, Gerson JE, Guerrero-Munoz M, Troncoso JC, Jackson GR, Kayed R
Acta neuropathologica communications 2014 May 29;2:56
Acta neuropathologica communications 2014 May 29;2:56
Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.
Kondadi AK, Wang S, Montagner S, Kladt N, Korwitz A, Martinelli P, Herholz D, Baker MJ, Schauss AC, Langer T, Rugarli EI
The EMBO journal 2014 May 2;33(9):1011-26
The EMBO journal 2014 May 2;33(9):1011-26
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
Shilling D, Müller M, Takano H, Mak DO, Abel T, Coulter DA, Foskett JK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 14;34(20):6910-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 14;34(20):6910-23
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Yamada ES, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, Rastetter A, Tarze A, Friguet B, Salama M, Champy P, Oertel WH, Höglinger GU
Experimental neurology 2014 Mar;253:113-25
Experimental neurology 2014 Mar;253:113-25
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, Laferla FM
The American journal of pathology 2014 Mar;184(3):819-26
The American journal of pathology 2014 Mar;184(3):819-26
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Orr ME, Salinas A, Buffenstein R, Oddo S
Neurobiology of aging 2014 Jun;35(6):1233-42
Neurobiology of aging 2014 Jun;35(6):1233-42
Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?
Pan JJ, Lee M, Honig LS, Vonsattel JP, Faust PL, Louis ED
Parkinsonism & related disorders 2014 Jun;20(6):655-8
Parkinsonism & related disorders 2014 Jun;20(6):655-8
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
Torres M, Price SL, Fiol-Deroque MA, Marcilla-Etxenike A, Ahyayauch H, Barceló-Coblijn G, Terés S, Katsouri L, Ordinas M, López DJ, Ibarguren M, Goñi FM, Busquets X, Vitorica J, Sastre M, Escribá PV
Biochimica et biophysica acta 2014 Jun;1838(6):1680-92
Biochimica et biophysica acta 2014 Jun;1838(6):1680-92
P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.
Pehar M, Ko MH, Li M, Scrable H, Puglielli L
Aging cell 2014 Jun;13(3):449-56
Aging cell 2014 Jun;13(3):449-56
Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.
García-Mesa Y, Pareja-Galeano H, Bonet-Costa V, Revilla S, Gómez-Cabrera MC, Gambini J, Giménez-Llort L, Cristòfol R, Viña J, Sanfeliu C
Psychoneuroendocrinology 2014 Jul;45:154-66
Psychoneuroendocrinology 2014 Jul;45:154-66
Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.
Palm R, Chang J, Blair J, Garcia-Mesa Y, Lee HG, Castellani RJ, Smith MA, Zhu X, Casadesus G
Journal of neurochemistry 2014 Jul;130(1):115-25
Journal of neurochemistry 2014 Jul;130(1):115-25
Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG
Journal of neurochemistry 2014 Jan;128(1):162-72
Journal of neurochemistry 2014 Jan;128(1):162-72
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM
Neurobiology of disease 2014 Feb;62:407-15
Neurobiology of disease 2014 Feb;62:407-15
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H
Neuropharmacology 2014 Apr;79:307-13
Neuropharmacology 2014 Apr;79:307-13
Visualizing the microtubule-associated protein tau in the nucleus.
Lu J, Li T, He R, Bartlett PF, Götz J
Science China. Life sciences 2014 Apr;57(4):422-31
Science China. Life sciences 2014 Apr;57(4):422-31
Ubiquilin 2 is not associated with tau pathology.
Nölle A, van Haastert ES, Zwart R, Hoozemans JJ, Scheper W
PloS one 2013;8(9):e76598
PloS one 2013;8(9):e76598
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E
PloS one 2013;8(7):e68722
PloS one 2013;8(7):e68722
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M, Kappos L, Goedert M, Tolnay M, Winkler DT
PloS one 2013;8(5):e62459
PloS one 2013;8(5):e62459
PINCH in the cellular stress response to tau-hyperphosphorylation.
Ozdemir AY, Rom I, Kovalevich J, Yen W, Adiga R, Dave RS, Langford D
PloS one 2013;8(3):e58232
PloS one 2013;8(3):e58232
Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease.
Levarska L, Zilka N, Jadhav S, Neradil P, Novak M
Journal of Alzheimer's disease : JAD 2013;37(3):569-77
Journal of Alzheimer's disease : JAD 2013;37(3):569-77
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M
Journal of Alzheimer's disease : JAD 2013;37(1):217-32
Journal of Alzheimer's disease : JAD 2013;37(1):217-32
Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage.
Manczak M, Reddy PH
Journal of Alzheimer's disease : JAD 2013;36(2):285-95
Journal of Alzheimer's disease : JAD 2013;36(2):285-95
SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Capsoni S, Carlo AS, Vignone D, Amato G, Criscuolo C, Willnow TE, Cattaneo A
Journal of Alzheimer's disease : JAD 2013;33(2):357-71
Journal of Alzheimer's disease : JAD 2013;33(2):357-71
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B
Neuro-degenerative diseases 2013;11(4):194-205
Neuro-degenerative diseases 2013;11(4):194-205
Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.
Chen RJ, Chang WW, Lin YC, Cheng PL, Chen YR
ACS chemical neuroscience 2013 Sep 18;4(9):1287-96
ACS chemical neuroscience 2013 Sep 18;4(9):1287-96
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN
Biological psychiatry 2013 Sep 1;74(5):357-66
Biological psychiatry 2013 Sep 1;74(5):357-66
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.
Anumala UR, Gu J, Lo Monte F, Kramer T, Heyny-von Haußen R, Hölzer J, Goetschy-Meyer V, Schön C, Mall G, Hilger I, Czech C, Herms J, Schmidt B
Bioorganic & medicinal chemistry 2013 Sep 1;21(17):5139-44
Bioorganic & medicinal chemistry 2013 Sep 1;21(17):5139-44
A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease.
Hensley K, Gabbita SP, Venkova K, Hristov A, Johnson MF, Eslami P, Harris-White ME
Journal of neuropathology and experimental neurology 2013 Oct;72(10):955-69
Journal of neuropathology and experimental neurology 2013 Oct;72(10):955-69
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
Josephs KA, Dickson DW, Murray ME, Senjem ML, Parisi JE, Petersen RC, Jack CR Jr, Whitwell JL
Brain and language 2013 Nov;127(2):127-34
Brain and language 2013 Nov;127(2):127-34
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J
Acta neuropathologica communications 2013 Nov 12;1:73
Acta neuropathologica communications 2013 Nov 12;1:73
Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.
Zufferey V, Vallet PG, Moeri M, Moulin-Sallanon M, Piotton F, Marin P, Savioz A
Brain research bulletin 2013 May;94:17-22
Brain research bulletin 2013 May;94:17-22
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Köhler C, Dinekov M, Götz J
Neurobiology of aging 2013 May;34(5):1369-79
Neurobiology of aging 2013 May;34(5):1369-79
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike CJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 15;33(20):8891-7
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 15;33(20):8891-7
Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system.
Feldengut S, Del Tredici K, Braak H
Journal of neuroscience methods 2013 May 15;215(2):241-4
Journal of neuroscience methods 2013 May 15;215(2):241-4
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.
Colom-Cadena M, Gelpi E, Martí MJ, Charif S, Dols-Icardo O, Blesa R, Clarimón J, Lleó A
Neurobiology of aging 2013 Mar;34(3):936-42
Neurobiology of aging 2013 Mar;34(3):936-42
Making the diagnosis of frontotemporal lobar degeneration.
Bigio EH
Archives of pathology & laboratory medicine 2013 Mar;137(3):314-25
Archives of pathology & laboratory medicine 2013 Mar;137(3):314-25
Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.
Gu J, Anumala UR, Heyny-von Haußen R, Hölzer J, Goetschy-Meyer V, Mall G, Hilger I, Czech C, Schmidt B
ChemMedChem 2013 Jun;8(6):891-7
ChemMedChem 2013 Jun;8(6):891-7
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Nash KR, Lee DC, Hunt JB Jr, Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D
Neurobiology of aging 2013 Jun;34(6):1540-8
Neurobiology of aging 2013 Jun;34(6):1540-8
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Sengupta U, Prough DS, Jackson GR, DeWitt DS, Kayed R
The Journal of biological chemistry 2013 Jun 7;288(23):17042-17050
The Journal of biological chemistry 2013 Jun 7;288(23):17042-17050
Clinical correlates in an experimental model of repetitive mild brain injury.
Mannix R, Meehan WP, Mandeville J, Grant PE, Gray T, Berglass J, Zhang J, Bryant J, Rezaie S, Chung JY, Peters NV, Lee C, Tien LW, Kaplan DL, Feany M, Whalen M
Annals of neurology 2013 Jul;74(1):65-75
Annals of neurology 2013 Jul;74(1):65-75
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
Alonso E, Vale C, Vieytes MR, Botana LM
ACS chemical neuroscience 2013 Jul 17;4(7):1062-70
ACS chemical neuroscience 2013 Jul 17;4(7):1062-70
Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.
Braak H, Thal DR, Matschke J, Ghebremedhin E, Del Tredici K
Neurobiology of aging 2013 Jan;34(1):286-97
Neurobiology of aging 2013 Jan;34(1):286-97
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.
Vepsäläinen S, Koivisto H, Pekkarinen E, Mäkinen P, Dobson G, McDougall GJ, Stewart D, Haapasalo A, Karjalainen RO, Tanila H, Hiltunen M
The Journal of nutritional biochemistry 2013 Jan;24(1):360-70
The Journal of nutritional biochemistry 2013 Jan;24(1):360-70
Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.
Choi SH, Aid S, Caracciolo L, Minami SS, Niikura T, Matsuoka Y, Turner RS, Mattson MP, Bosetti F
Journal of neurochemistry 2013 Jan;124(1):59-68
Journal of neurochemistry 2013 Jan;124(1):59-68
Age-related loss of noradrenergic neurons in the brains of triple transgenic mice.
Manaye KF, Mouton PR, Xu G, Drew A, Lei DL, Sharma Y, Rebeck GW, Turner S
Age (Dordrecht, Netherlands) 2013 Feb;35(1):139-47
Age (Dordrecht, Netherlands) 2013 Feb;35(1):139-47
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Cancino GI, Miller FD, Kaplan DR
Neurobiology of aging 2013 Feb;34(2):387-99
Neurobiology of aging 2013 Feb;34(2):387-99
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration.
Pirker S, Perju-Dumbrava L, Kovacs GG, Traub-Weidinger T, Asenbaum S, Pirker W
Parkinsonism & related disorders 2013 Feb;19(2):222-6
Parkinsonism & related disorders 2013 Feb;19(2):222-6
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance.
López-Menéndez C, Gamir-Morralla A, Jurado-Arjona J, Higuero AM, Campanero MR, Ferrer I, Hernández F, Ávila J, Díaz-Guerra M, Iglesias T
Human molecular genetics 2013 Feb 1;22(3):466-82
Human molecular genetics 2013 Feb 1;22(3):466-82
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, Herms J
Acta neuropathologica communications 2013 Dec 17;1:82
Acta neuropathologica communications 2013 Dec 17;1:82
Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
Geekiyanage H, Upadhye A, Chan C
Neurobiology of aging 2013 Aug;34(8):2037-51
Neurobiology of aging 2013 Aug;34(8):2037-51
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.
Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD
Aging cell 2013 Apr;12(2):257-68
Aging cell 2013 Apr;12(2):257-68
NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.
Tackenberg C, Grinschgl S, Trutzel A, Santuccione AC, Frey MC, Konietzko U, Grimm J, Brandt R, Nitsch RM
Cell death & disease 2013 Apr 25;4(4):e608
Cell death & disease 2013 Apr 25;4(4):e608
Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
Merkwirth C, Martinelli P, Korwitz A, Morbin M, Brönneke HS, Jordan SD, Rugarli EI, Langer T
PLoS genetics 2012;8(11):e1003021
PLoS genetics 2012;8(11):e1003021
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L
PloS one 2012;7(9):e45881
PloS one 2012;7(9):e45881
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
Castello NA, Green KN, LaFerla FM
PloS one 2012;7(8):e39566
PloS one 2012;7(8):e39566
Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.
Julien C, Marcouiller F, Bretteville A, El Khoury NB, Baillargeon J, Hébert SS, Planel E
PloS one 2012;7(6):e40020
PloS one 2012;7(6):e40020
Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.
Capsoni S, Marinelli S, Ceci M, Vignone D, Amato G, Malerba F, Paoletti F, Meli G, Viegi A, Pavone F, Cattaneo A
PloS one 2012;7(5):e37555
PloS one 2012;7(5):e37555
High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Herzig MC, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, Danner S, Vidotto N, Stauffer D, Barske C, Mayer F, Schmid P, Rovelli G, van der Putten PH, Shimshek DR
PloS one 2012;7(5):e36581
PloS one 2012;7(5):e36581
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
Sudduth TL, Wilson JG, Everhart A, Colton CA, Wilcock DM
PloS one 2012;7(2):e31993
PloS one 2012;7(2):e31993
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J
PloS one 2012;7(12):e53547
PloS one 2012;7(12):e53547
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, Maruyama H, Ichikawa T, Obata F
PloS one 2012;7(1):e30834
PloS one 2012;7(1):e30834
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
Joshi YB, Chu J, Praticò D
Journal of Alzheimer's disease : JAD 2012;31(1):167-76
Journal of Alzheimer's disease : JAD 2012;31(1):167-76
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Clausen A, Xu X, Bi X, Baudry M
Journal of Alzheimer's disease : JAD 2012;30(1):183-208
Journal of Alzheimer's disease : JAD 2012;30(1):183-208
Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.
Giustiniani J, Sineus M, Sardin E, Dounane O, Panchal M, Sazdovitch V, Duyckaerts C, Chambraud B, Baulieu EE
Journal of Alzheimer's disease : JAD 2012;29(2):471-83
Journal of Alzheimer's disease : JAD 2012;29(2):471-83
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.
Venkataramani V, Wirths O, Budka H, Härtig W, Kovacs GG, Bayer TA
Journal of Alzheimer's disease : JAD 2012;29(2):361-71
Journal of Alzheimer's disease : JAD 2012;29(2):361-71
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.
Cuadrado-Tejedor M, Ricobaraza A, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A
Journal of Alzheimer's disease : JAD 2012;28(3):567-78
Journal of Alzheimer's disease : JAD 2012;28(3):567-78
Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy.
Antonell A, Gelpi E, Sánchez-Valle R, Martínez R, Molinuevo JL, Lladó A
Journal of Alzheimer's disease : JAD 2012;28(2):303-8
Journal of Alzheimer's disease : JAD 2012;28(2):303-8
Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.
Elipenahli C, Stack C, Jainuddin S, Gerges M, Yang L, Starkov A, Beal MF, Dumont M
Journal of Alzheimer's disease : JAD 2012;28(1):173-82
Journal of Alzheimer's disease : JAD 2012;28(1):173-82
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A
Molecular neurodegeneration 2012 Sep 21;7:48
Molecular neurodegeneration 2012 Sep 21;7:48
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Britschgi M, Takeda-Uchimura Y, Rockenstein E, Johns H, Masliah E, Wyss-Coray T
Journal of neuroinflammation 2012 Sep 18;9:220
Journal of neuroinflammation 2012 Sep 18;9:220
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
Mondragón-Rodríguez S, Trillaud-Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, Boehm J
The Journal of biological chemistry 2012 Sep 14;287(38):32040-53
The Journal of biological chemistry 2012 Sep 14;287(38):32040-53
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Krüger U, Wang Y, Kumar S, Mandelkow EM
Neurobiology of aging 2012 Oct;33(10):2291-305
Neurobiology of aging 2012 Oct;33(10):2291-305
Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia.
Woehrer A, Laszlo L, Finsterer J, Stöllberger C, Furtner J, Rinner W, Molnar K, Budka H, Kovacs GG
Acta neuropathologica 2012 Oct;124(4):583-91
Acta neuropathologica 2012 Oct;124(4):583-91
STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.
van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans CB
Neuroscience letters 2012 Oct 24;528(2):104-9
Neuroscience letters 2012 Oct 24;528(2):104-9
Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway.
Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, Ikeuchi T
The Journal of biological chemistry 2012 Oct 12;287(42):35222-33
The Journal of biological chemistry 2012 Oct 12;287(42):35222-33
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
Boländer A, Kieser D, Voss C, Bauer S, Schön C, Burgold S, Bittner T, Hölzer J, Heyny-von Haußen R, Mall G, Goetschy V, Czech C, Knust H, Berger R, Herms J, Hilger I, Schmidt B
Journal of medicinal chemistry 2012 Nov 8;55(21):9170-80
Journal of medicinal chemistry 2012 Nov 8;55(21):9170-80
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
Hong Y, Chan CB, Kwon IS, Li X, Song M, Lee HP, Liu X, Sompol P, Jin P, Lee HG, Yu SP, Ye K
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 28;32(48):17262-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 28;32(48):17262-72
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J
Molecular neurodegeneration 2012 Nov 22;7:59
Molecular neurodegeneration 2012 Nov 22;7:59
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Löffler T, Flunkert S, Taub N, Schofield EL, Ward MA, Windisch M, Hutter-Paier B
Journal of molecular neuroscience : MN 2012 May;47(1):192-203
Journal of molecular neuroscience : MN 2012 May;47(1):192-203
Antemortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies.
Kantarci K, Yang C, Schneider JA, Senjem ML, Reyes DA, Lowe VJ, Barnes LL, Aggarwal NT, Bennett DA, Smith GE, Petersen RC, Jack CR Jr, Boeve BF
Neurobiology of aging 2012 May;33(5):878-85
Neurobiology of aging 2012 May;33(5):878-85
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR, Kayed R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):1946-59
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):1946-59
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, Decarr LB, Yang L, Liu V, Fessler C, Protassio J, Riff T, Turner H, Janus CG, Sankaranarayanan S, Polson C, Meredith JE, Gray G, Hanna A, Olson RE, Kim SH, Vite GD, Lee FY, Albright CF
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May 23;32(21):7137-45
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May 23;32(21):7137-45
Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.
Orejana L, Barros-Miñones L, Jordán J, Puerta E, Aguirre N
Neurobiology of aging 2012 Mar;33(3):625.e11-20
Neurobiology of aging 2012 Mar;33(3):625.e11-20
Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.
Lee HJ, Lee JK, Lee H, Carter JE, Chang JW, Oh W, Yang YS, Suh JG, Lee BH, Jin HK, Bae JS
Neurobiology of aging 2012 Mar;33(3):588-602
Neurobiology of aging 2012 Mar;33(3):588-602
Asymmetry of neurodegenerative disease-related pathologies: a cautionary note.
Stefanits H, Budka H, Kovacs GG
Acta neuropathologica 2012 Mar;123(3):449-52
Acta neuropathologica 2012 Mar;123(3):449-52
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts.
Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M
Acta neuropathologica 2012 Mar;123(3):381-94
Acta neuropathologica 2012 Mar;123(3):381-94
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.
García-Mesa Y, Giménez-Llort L, López LC, Venegas C, Cristòfol R, Escames G, Acuña-Castroviejo D, Sanfeliu C
Neurobiology of aging 2012 Jun;33(6):1124.e13-29
Neurobiology of aging 2012 Jun;33(6):1124.e13-29
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Al-Shemary T
Neurotoxicology 2012 Jun;33(3):370-83
Neurotoxicology 2012 Jun;33(3):370-83
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Kapas I, Majtenyi K, Törö K, Keller E, Voigtländer T, Kovacs GG
Metabolic brain disease 2012 Jun;27(2):231-5
Metabolic brain disease 2012 Jun;27(2):231-5
Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.
Petratos S, Ozturk E, Azari MF, Kenny R, Lee JY, Magee KA, Harvey AR, McDonald C, Taghian K, Moussa L, Mun Aui P, Siatskas C, Litwak S, Fehlings MG, Strittmatter SM, Bernard CC
Brain : a journal of neurology 2012 Jun;135(Pt 6):1794-818
Brain : a journal of neurology 2012 Jun;135(Pt 6):1794-818
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.
Van der Jeugd A, Hochgräfe K, Ahmed T, Decker JM, Sydow A, Hofmann A, Wu D, Messing L, Balschun D, D'Hooge R, Mandelkow EM
Acta neuropathologica 2012 Jun;123(6):787-805
Acta neuropathologica 2012 Jun;123(6):787-805
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T
The Journal of biological chemistry 2012 Jun 1;287(23):19715-24
The Journal of biological chemistry 2012 Jun 1;287(23):19715-24
First transgenic rat model developing progressive cortical neurofibrillary tangles.
Filipcik P, Zilka N, Bugos O, Kucerak J, Koson P, Novak P, Novak M
Neurobiology of aging 2012 Jul;33(7):1448-56
Neurobiology of aging 2012 Jul;33(7):1448-56
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Ksiezak-Reding H, Ho L, Santa-Maria I, Diaz-Ruiz C, Wang J, Pasinetti GM
Neurobiology of aging 2012 Jul;33(7):1427-39
Neurobiology of aging 2012 Jul;33(7):1427-39
Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology.
Morawski M, Brückner G, Jäger C, Seeger G, Matthews RT, Arendt T
Brain pathology (Zurich, Switzerland) 2012 Jul;22(4):547-61
Brain pathology (Zurich, Switzerland) 2012 Jul;22(4):547-61
Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology.
Piccardo P, Cervenak J, Yakovleva O, Gregori L, Pomeroy K, Cook A, Muhammad FS, Seuberlich T, Cervenakova L, Asher DM
Journal of comparative pathology 2012 Jul;147(1):84-93
Journal of comparative pathology 2012 Jul;147(1):84-93
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
Wang HY, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah SM, Burns LH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jul 18;32(29):9773-84
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jul 18;32(29):9773-84
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.
Mustroph ML, King MA, Klein RL, Ramirez JJ
Behavioural brain research 2012 Jul 15;233(1):141-8
Behavioural brain research 2012 Jul 15;233(1):141-8
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Khandelwal PJ, Dumanis SB, Herman AM, Rebeck GW, Moussa CE
Molecular and cellular neurosciences 2012 Jan;49(1):44-53
Molecular and cellular neurosciences 2012 Jan;49(1):44-53
Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
Wilhelmus MM, de Jager M, Rozemuller AJ, Brevé J, Bol JG, Eckert RL, Drukarch B
The Journal of pathology 2012 Jan;226(1):132-42
The Journal of pathology 2012 Jan;226(1):132-42
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.
Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A
Acta neuropathologica 2012 Jan;123(1):53-70
Acta neuropathologica 2012 Jan;123(1):53-70
Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling.
Chen LM, Xiong YS, Kong FL, Qu M, Wang Q, Chen XQ, Wang JZ, Zhu LQ
Journal of neurochemistry 2012 Jan;120(1):157-64
Journal of neurochemistry 2012 Jan;120(1):157-64
Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.
Sundaram JR, Chan ES, Poore CP, Pareek TK, Cheong WF, Shui G, Tang N, Low CM, Wenk MR, Kesavapany S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jan 18;32(3):1020-34
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jan 18;32(3):1020-34
(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains.
Li L, Zhang ZF, Holscher C, Gao C, Jiang YH, Liu YZ
European journal of pharmacology 2012 Jan 15;674(2-3):280-6
European journal of pharmacology 2012 Jan 15;674(2-3):280-6
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
Perez SE, Getova DP, He B, Counts SE, Geula C, Desire L, Coutadeur S, Peillon H, Ginsberg SD, Mufson EJ
The American journal of pathology 2012 Feb;180(2):526-40
The American journal of pathology 2012 Feb;180(2):526-40
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Attur S
Acta biologica Hungarica 2012 Dec;63(4):411-25
Acta biologica Hungarica 2012 Dec;63(4):411-25
Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer's disease.
Schauer TH, Lochner M, Kovacs GG
Journal of neural transmission (Vienna, Austria : 1996) 2012 Dec;119(12):1545-9
Journal of neural transmission (Vienna, Austria : 1996) 2012 Dec;119(12):1545-9
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
Yao J, Ho D, Calingasan NY, Pipalia NH, Lin MT, Beal MF
The Journal of experimental medicine 2012 Dec 17;209(13):2501-13
The Journal of experimental medicine 2012 Dec 17;209(13):2501-13
Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.
Yokota T, Akatsu H, Miyauchi T, Heese K
FEBS letters 2012 Dec 14;586(24):4357-61
FEBS letters 2012 Dec 14;586(24):4357-61
Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice.
Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, Calingasan NY, Yang L, Tampellini D, Starkov AA, Chan RB, Di Paolo G, Pujol A, Beal MF
Human molecular genetics 2012 Dec 1;21(23):5091-105
Human molecular genetics 2012 Dec 1;21(23):5091-105
Cerebral amyloid β(42) deposits and microvascular pathology in ageing baboons.
Ndung'u M, Härtig W, Wegner F, Mwenda JM, Low RW, Akinyemi RO, Kalaria RN
Neuropathology and applied neurobiology 2012 Aug;38(5):487-99
Neuropathology and applied neurobiology 2012 Aug;38(5):487-99
Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters.
Gerhauser I, Wohlsein P, Ernst H, Germann PG, Baumgärtner W
Neurobiology of aging 2012 Aug;33(8):1716-9
Neurobiology of aging 2012 Aug;33(8):1716-9
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM
The American journal of pathology 2012 Aug;181(2):616-25
The American journal of pathology 2012 Aug;181(2):616-25
Hirano body-rich subtypes of Creutzfeldt-Jakob disease.
Martinez-Saez E, Gelpi E, Rey MJ, Ferrer I, Ribalta T, Botta-Orfila T, Nos C, Yagüe J, Sanchez-Valle R
Neuropathology and applied neurobiology 2012 Apr;38(2):153-61
Neuropathology and applied neurobiology 2012 Apr;38(2):153-61
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.
Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K
Neuropathology and applied neurobiology 2012 Apr;38(2):132-41
Neuropathology and applied neurobiology 2012 Apr;38(2):132-41
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK
Neurobiology of aging 2012 Apr;33(4):828.e31-44
Neurobiology of aging 2012 Apr;33(4):828.e31-44
Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.
Minami SS, Clifford TG, Hoe HS, Matsuoka Y, Rebeck GW
Neurobiology of aging 2012 Apr;33(4):825.e15-24
Neurobiology of aging 2012 Apr;33(4):825.e15-24
"Preclinical" MSA in definite Creutzfeldt-Jakob disease.
Rodriguez-Diehl R, Rey MJ, Gironell A, Martinez-Saez E, Ferrer I, Sánchez-Valle R, Jagüe J, Nos C, Gelpi E
Neuropathology : official journal of the Japanese Society of Neuropathology 2012 Apr;32(2):158-63
Neuropathology : official journal of the Japanese Society of Neuropathology 2012 Apr;32(2):158-63
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
Nijholt DA, van Haastert ES, Rozemuller AJ, Scheper W, Hoozemans JJ
The Journal of pathology 2012 Apr;226(5):693-702
The Journal of pathology 2012 Apr;226(5):693-702
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SE
The Journal of clinical investigation 2012 Apr;122(4):1316-38
The Journal of clinical investigation 2012 Apr;122(4):1316-38
Frontal cortex neuropathology in dementia pugilistica.
Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E
Journal of neurotrauma 2012 Apr 10;29(6):1054-70
Journal of neurotrauma 2012 Apr 10;29(6):1054-70
Rapid changes in phospho-MAP/tau epitopes during neuronal stress: cofilin-actin rods primarily recruit microtubule binding domain epitopes.
Whiteman IT, Minamide LS, Goh de L, Bamburg JR, Goldsbury C
PloS one 2011;6(6):e20878
PloS one 2011;6(6):e20878
Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway.
Silva DF, Esteves AR, Arduino DM, Oliveira CR, Cardoso SM
Journal of Alzheimer's disease : JAD 2011;26(3):565-81
Journal of Alzheimer's disease : JAD 2011;26(3):565-81
A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death.
Li L, Cheung T, Chen J, Herrup K
International journal of Alzheimer's disease 2011;2011:171464
International journal of Alzheimer's disease 2011;2011:171464
Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.
Ferreira A, Bigio EH
Molecular medicine (Cambridge, Mass.) 2011;17(7-8):676-85
Molecular medicine (Cambridge, Mass.) 2011;17(7-8):676-85
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Copenhaver PF, Anekonda TS, Musashe D, Robinson KM, Ramaker JM, Swanson TL, Wadsworth TL, Kretzschmar D, Woltjer RL, Quinn JF
Disease models & mechanisms 2011 Sep;4(5):634-48
Disease models & mechanisms 2011 Sep;4(5):634-48
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
Whitwell JL, Jack CR Jr, Przybelski SA, Parisi JE, Senjem ML, Boeve BF, Knopman DS, Petersen RC, Dickson DW, Josephs KA
Neurobiology of aging 2011 Sep;32(9):1531-41
Neurobiology of aging 2011 Sep;32(9):1531-41
Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene.
Hagen MC, Murrell JR, Delisle MB, Andermann E, Andermann F, Guiot MC, Ghetti B
Brain pathology (Zurich, Switzerland) 2011 Sep;21(5):575-82
Brain pathology (Zurich, Switzerland) 2011 Sep;21(5):575-82
Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.
Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, Buckner N, Hanmer J, Davies P, O'Neill MJ, Hutton ML, Citron M
The Journal of biological chemistry 2011 Sep 30;286(39):34457-67
The Journal of biological chemistry 2011 Sep 30;286(39):34457-67
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L
The Journal of biological chemistry 2011 Sep 16;286(37):32713-22
The Journal of biological chemistry 2011 Sep 16;286(37):32713-22
Microglial pathology in Down syndrome.
Xue QS, Streit WJ
Acta neuropathologica 2011 Oct;122(4):455-66
Acta neuropathologica 2011 Oct;122(4):455-66
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.
Emmer KL, Waxman EA, Covy JP, Giasson BI
The Journal of biological chemistry 2011 Oct 7;286(40):35104-18
The Journal of biological chemistry 2011 Oct 7;286(40):35104-18
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
Li X, Kumar Y, Zempel H, Mandelkow EM, Biernat J, Mandelkow E
The EMBO journal 2011 Oct 18;30(23):4825-37
The EMBO journal 2011 Oct 18;30(23):4825-37
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.
Braak H, Thal DR, Ghebremedhin E, Del Tredici K
Journal of neuropathology and experimental neurology 2011 Nov;70(11):960-9
Journal of neuropathology and experimental neurology 2011 Nov;70(11):960-9
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
McMillan PJ, Kraemer BC, Robinson L, Leverenz JB, Raskind M, Schellenberg G
Journal of neuropathology and experimental neurology 2011 Nov;70(11):1006-19
Journal of neuropathology and experimental neurology 2011 Nov;70(11):1006-19
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.
Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova NN, Yang L, Starkov AA, Beal F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Nov;25(11):4063-72
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Nov;25(11):4063-72
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.
Wilhelmus MM, Bol JG, Van Haastert ES, Rozemuller AJ, Bu G, Drukarch B, Hoozemans JJ
The American journal of pathology 2011 Nov;179(5):2152-6
The American journal of pathology 2011 Nov;179(5):2152-6
ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Green KN, Khashwji H, Estrada T, Laferla FM
Annals of neurology 2011 May;69(5):831-44
Annals of neurology 2011 May;69(5):831-44
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases.
Braak H, Thal DR, Del Tredici K
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):809-19
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):809-19
Fronto-temporal lobar degeneration: neuropathology in 60 cases.
Seilhean D, Le Ber I, Sarazin M, Lacomblez L, Millecamps S, Salachas F, Pradat PF, Le Forestier N, LeGuern E, Dubois B, Meininger V, Brice A, Hauw JJ, Duyckaerts C
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):753-64
Journal of neural transmission (Vienna, Austria : 1996) 2011 May;118(5):753-64
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Koike MA, Garcia FG, Kitazawa M, Green KN, Laferla FM
Neuroscience letters 2011 May 9;495(1):55-9
Neuroscience letters 2011 May 9;495(1):55-9
Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.
Waxman EA, Giasson BI
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 May 25;31(21):7604-18
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 May 25;31(21):7604-18
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.
Rusina R, Kovacs GG, Fiala J, Hort J, Ridzoň P, Holmerová I, Ströbel T, Matěj R
BMC neurology 2011 May 10;11:50
BMC neurology 2011 May 10;11:50
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean ME, Humez S, Balschun D, Blum D, Buée L, D'Hooge R
Neurobiology of learning and memory 2011 Mar;95(3):296-304
Neurobiology of learning and memory 2011 Mar;95(3):296-304
Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.
Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, Soriano S
Journal of molecular neuroscience : MN 2011 Mar;43(3):326-32
Journal of molecular neuroscience : MN 2011 Mar;43(3):326-32
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):189-200
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):189-200
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
Wilhelmus MM, Verhaar R, Andringa G, Bol JG, Cras P, Shan L, Hoozemans JJ, Drukarch B
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):130-9
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):130-9
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.
Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
The Journal of biological chemistry 2011 Mar 4;286(9):7619-28
The Journal of biological chemistry 2011 Mar 4;286(9):7619-28
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 23;31(12):4720-30
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 23;31(12):4720-30
Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.
Talbot K, Louneva N, Cohen JW, Kazi H, Blake DJ, Arnold SE
PloS one 2011 Mar 1;6(3):e16886
PloS one 2011 Mar 1;6(3):e16886
Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.
Nunes A, Pressey SN, Cooper JD, Soriano S
Neurobiology of disease 2011 Jun;42(3):349-59
Neurobiology of disease 2011 Jun;42(3):349-59
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Takahashi RH, Tobiume M, Sato Y, Sata T, Gouras GK, Takahashi H
Neuropathology : official journal of the Japanese Society of Neuropathology 2011 Jun;31(3):208-14
Neuropathology : official journal of the Japanese Society of Neuropathology 2011 Jun;31(3):208-14
Rapidly progressive diffuse Lewy body disease.
Gaig C, Valldeoriola F, Gelpi E, Ezquerra M, Llufriu S, Buongiorno M, Rey MJ, Martí MJ, Graus F, Tolosa E
Movement disorders : official journal of the Movement Disorder Society 2011 Jun;26(7):1316-23
Movement disorders : official journal of the Movement Disorder Society 2011 Jun;26(7):1316-23
ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia.
Castro-Alvarez JF, Gutierrez-Vargas J, Darnaudéry M, Cardona-Gómez GP
Behavioral neuroscience 2011 Jun;125(3):465-72
Behavioral neuroscience 2011 Jun;125(3):465-72
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
Tran HT, LaFerla FM, Holtzman DM, Brody DL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG
Journal of neuropathology and experimental neurology 2011 Jul;70(7):578-87
Journal of neuropathology and experimental neurology 2011 Jul;70(7):578-87
Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension.
Goodwin JE, Zhang J, Gonzalez D, Albinsson S, Geller DS
Journal of hypertension 2011 Jul;29(7):1347-56
Journal of hypertension 2011 Jul;29(7):1347-56
Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease.
Sepulveda-Falla D, Matschke J, Bernreuther C, Hagel C, Puig B, Villegas A, Garcia G, Zea J, Gomez-Mancilla B, Ferrer I, Lopera F, Glatzel M
Brain pathology (Zurich, Switzerland) 2011 Jul;21(4):452-63
Brain pathology (Zurich, Switzerland) 2011 Jul;21(4):452-63
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.
Cuadrado-Tejedor M, Ricobaraza A, Del Río J, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A
Behavioural brain research 2011 Jul 7;220(2):338-43
Behavioural brain research 2011 Jul 7;220(2):338-43
Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases.
Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jul 6;31(27):9858-68
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jul 6;31(27):9858-68
Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.
Engmann O, Hortobágyi T, Thompson AJ, Guadagno J, Troakes C, Soriano S, Al-Sarraj S, Kim Y, Giese KP
Biological psychiatry 2011 Jul 15;70(2):159-68
Biological psychiatry 2011 Jul 15;70(2):159-68
Protein aggregation in the aging retina.
Leger F, Fernagut PO, Canron MH, Léoni S, Vital C, Tison F, Bezard E, Vital A
Journal of neuropathology and experimental neurology 2011 Jan;70(1):63-8
Journal of neuropathology and experimental neurology 2011 Jan;70(1):63-8
WNT signaling in activated microglia is proinflammatory.
Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobágyi T, Tanila H, Kumar Puli L, Färber K, Harkany T, Schulte G
Glia 2011 Jan;59(1):119-31
Glia 2011 Jan;59(1):119-31
Propofol directly increases tau phosphorylation.
Whittington RA, Virág L, Marcouiller F, Papon MA, El Khoury NB, Julien C, Morin F, Emala CW, Planel E
PloS one 2011 Jan 31;6(1):e16648
PloS one 2011 Jan 31;6(1):e16648
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
Stieler JT, Bullmann T, Kohl F, Tøien Ø, Brückner MK, Härtig W, Barnes BM, Arendt T
PloS one 2011 Jan 18;6(1):e14530
PloS one 2011 Jan 18;6(1):e14530
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.
Niikura T, Sidahmed E, Hirata-Fukae C, Aisen PS, Matsuoka Y
PloS one 2011 Jan 17;6(1):e16259
PloS one 2011 Jan 17;6(1):e16259
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Fonseca MI, Chu SH, Berci AM, Benoit ME, Peters DG, Kimura Y, Tenner AJ
Journal of neuroinflammation 2011 Jan 15;8(1):4
Journal of neuroinflammation 2011 Jan 15;8(1):4
Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation.
Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, Goate AM, Bird TD, Leverenz JB
Neuroscience letters 2011 Jan 10;487(3):287-92
Neuroscience letters 2011 Jan 10;487(3):287-92
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.
Ramirez JJ, Poulton WE, Knelson E, Barton C, King MA, Klein RL
Behavioural brain research 2011 Jan 1;216(1):332-40
Behavioural brain research 2011 Jan 1;216(1):332-40
Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.
Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J
Annals of neurology 2011 Feb;69(2):248-56
Annals of neurology 2011 Feb;69(2):248-56
Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.
Perez SE, He B, Muhammad N, Oh KJ, Fahnestock M, Ikonomovic MD, Mufson EJ
Neurobiology of disease 2011 Feb;41(2):338-52
Neurobiology of disease 2011 Feb;41(2):338-52
The pathological process underlying Alzheimer's disease in individuals under thirty.
Braak H, Del Tredici K
Acta neuropathologica 2011 Feb;121(2):171-81
Acta neuropathologica 2011 Feb;121(2):171-81
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 2;31(5):1688-92
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 2;31(5):1688-92
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 16;31(7):2511-25
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 16;31(7):2511-25
Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510).
Yang D, Xie Z, Stephenson D, Morton D, Hicks CD, Brown TM, Sriram R, O'Neill S, Raunig D, Bocan T
NeuroImage 2011 Feb 14;54(4):2652-8
NeuroImage 2011 Feb 14;54(4):2652-8
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Castellani RJ, Gupta Y, Sheng B, Siedlak SL, Harris PL, Coller JM, Perry G, Lee HG, Tabaton M, Smith MA, Wang X, Zhu X
Laboratory investigation; a journal of technical methods and pathology 2011 Dec;91(12):1777-86
Laboratory investigation; a journal of technical methods and pathology 2011 Dec;91(12):1777-86
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM
Neurochemistry international 2011 Dec;59(7):1056-65
Neurochemistry international 2011 Dec;59(7):1056-65
Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.
Cuadrado-Tejedor M, Hervias I, Ricobaraza A, Puerta E, Pérez-Roldán JM, García-Barroso C, Franco R, Aguirre N, García-Osta A
British journal of pharmacology 2011 Dec;164(8):2029-41
British journal of pharmacology 2011 Dec;164(8):2029-41
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
Ambegaokar SS, Jackson GR
Human molecular genetics 2011 Dec 15;20(24):4947-77
Human molecular genetics 2011 Dec 15;20(24):4947-77
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice.
Panaite PA, Kielar M, Kraftsik R, Gourdon G, Kuntzer T, Barakat-Walter I
Journal of neuropathology and experimental neurology 2011 Aug;70(8):678-85
Journal of neuropathology and experimental neurology 2011 Aug;70(8):678-85
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Belarbi K, Burnouf S, Fernandez-Gomez FJ, Laurent C, Lestavel S, Figeac M, Sultan A, Troquier L, Leboucher A, Caillierez R, Grosjean ME, Demeyer D, Obriot H, Brion I, Barbot B, Galas MC, Staels B, Humez S, Sergeant N, Schraen-Maschke S, Muhr-Tailleux A, Hamdane M, Buée L, Blum D
Neurobiology of disease 2011 Aug;43(2):486-94
Neurobiology of disease 2011 Aug;43(2):486-94
Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors.
Roe AD, Staup MA, Serrats J, Sawchenko PE, Rissman RA
The European journal of neuroscience 2011 Aug;34(3):448-56
The European journal of neuroscience 2011 Aug;34(3):448-56
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Kovacs GG, Molnár K, László L, Ströbel T, Botond G, Hönigschnabl S, Reiner-Concin A, Palkovits M, Fischer P, Budka H
Acta neuropathologica 2011 Aug;122(2):205-22
Acta neuropathologica 2011 Aug;122(2):205-22
Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.
Glöckner F, Meske V, Lütjohann D, Ohm TG
Journal of neuropathology and experimental neurology 2011 Apr;70(4):292-301
Journal of neuropathology and experimental neurology 2011 Apr;70(4):292-301
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
Jayadev S, Nochlin D, Poorkaj P, Steinbart EJ, Mastrianni JA, Montine TJ, Ghetti B, Schellenberg GD, Bird TD, Leverenz JB
Annals of neurology 2011 Apr;69(4):712-20
Annals of neurology 2011 Apr;69(4):712-20
αB-crystallin negative astrocytic inclusions.
Barnett BP, Bressler J, Chen T, Hutchins GM, Crain BJ, Kaufmann WE
Brain & development 2011 Apr;33(4):349-52
Brain & development 2011 Apr;33(4):349-52
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 5;108(14):5819-24
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 5;108(14):5819-24
Influence of water quality on cholesterol-induced tau pathology: preliminary data.
Sparks DL, Ziolkowski C, Lawmaster T, Martin T
International journal of Alzheimer's disease 2011 Apr 17;2011:987023
International journal of Alzheimer's disease 2011 Apr 17;2011:987023
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Blazquez-Llorca L, Garcia-Marin V, Defelipe J
Frontiers in neuroanatomy 2010;4:20
Frontiers in neuroanatomy 2010;4:20
Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.
Chen X, Wagener JF, Morgan DH, Hui L, Ghribi O, Geiger JD
Journal of Alzheimer's disease : JAD 2010;22(4):1289-303
Journal of Alzheimer's disease : JAD 2010;22(4):1289-303
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN
Journal of Alzheimer's disease : JAD 2010;21(2):527-42
Journal of Alzheimer's disease : JAD 2010;21(2):527-42
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.
Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G
Journal of Alzheimer's disease : JAD 2010;19(4):1155-67
Journal of Alzheimer's disease : JAD 2010;19(4):1155-67
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Liu XA, Liao K, Liu R, Wang HH, Zhang Y, Zhang Q, Wang Q, Li HL, Tian Q, Wang JZ
Journal of Alzheimer's disease : JAD 2010;19(3):953-62
Journal of Alzheimer's disease : JAD 2010;19(3):953-62
Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease.
Fujimura RK, Reiner T, Ma F, Phillips V, de las Pozas A, Dickson DW, Roos BA, Howard GA, Perez-Stable C
Journal of Alzheimer's disease : JAD 2010;19(1):97-109
Journal of Alzheimer's disease : JAD 2010;19(1):97-109
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE
Journal of neuropathology and experimental neurology 2010 Sep;69(9):918-29
Journal of neuropathology and experimental neurology 2010 Sep;69(9):918-29
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation.
Rodríguez-Navarro JA, Rodríguez L, Casarejos MJ, Solano RM, Gómez A, Perucho J, Cuervo AM, García de Yébenes J, Mena MA
Neurobiology of disease 2010 Sep;39(3):423-38
Neurobiology of disease 2010 Sep;39(3):423-38
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.
van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C
Neurobiology of disease 2010 Sep;39(3):265-71
Neurobiology of disease 2010 Sep;39(3):265-71
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.
Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJ
The European journal of neuroscience 2010 Sep;32(6):905-20
The European journal of neuroscience 2010 Sep;32(6):905-20
Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.
Ambegaokar SS, Jackson GR
Genetics 2010 Sep;186(1):435-42
Genetics 2010 Sep;186(1):435-42
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Minami SS, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, Rebeck GW, Prendergast JS, Dealwis C, Wetzel R, Bosetti F, Matsuoka Y, Hoe HS, Turner RS
Journal of neuroinflammation 2010 Sep 28;7:57
Journal of neuroinflammation 2010 Sep 28;7:57
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L
Neuron 2010 Sep 23;67(6):953-66
Neuron 2010 Sep 23;67(6):953-66
Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease.
Morawski M, Brückner G, Jäger C, Seeger G, Arendt T
Neuroscience 2010 Sep 1;169(3):1347-63
Neuroscience 2010 Sep 1;169(3):1347-63
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
Bertrand J, Sénéchal P, Zummo-Soucy M, Plouffe V, Leclerc N
Journal of neurochemistry 2010 Sep 1;114(5):1353-67
Journal of neurochemistry 2010 Sep 1;114(5):1353-67
Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.
Van Nostrand WE, Xu F, Rozemuller AJ, Colton CA
Stroke 2010 Oct;41(10 Suppl):S135-8
Stroke 2010 Oct;41(10 Suppl):S135-8
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.
Bhaskar K, Hobbs GA, Yen SH, Lee G
Neuropathology and applied neurobiology 2010 Oct;36(6):462-77
Neuropathology and applied neurobiology 2010 Oct;36(6):462-77
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM
The American journal of pathology 2010 Oct;177(4):1977-88
The American journal of pathology 2010 Oct;177(4):1977-88
Regulation of tau pathology by the microglial fractalkine receptor.
Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT
Neuron 2010 Oct 6;68(1):19-31
Neuron 2010 Oct 6;68(1):19-31
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
Peethumnongsin E, Yang L, Kallhoff-Muñoz V, Hu L, Takashima A, Pautler RG, Zheng H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 6;30(40):13409-18
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 6;30(40):13409-18
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
Zheng YL, Amin ND, Hu YF, Rudrabhatla P, Shukla V, Kanungo J, Kesavapany S, Grant P, Albers W, Pant HC
The Journal of biological chemistry 2010 Oct 29;285(44):34202-12
The Journal of biological chemistry 2010 Oct 29;285(44):34202-12
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, Shirai Y, Horie K, Saito N, Takeda J, Hara H
PloS one 2010 Oct 18;5(10):e13447
PloS one 2010 Oct 18;5(10):e13447
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 13;30(41):13707-17
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 13;30(41):13707-17
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease.
Stozicka Z, Zilka N, Novak P, Kovacech B, Bugos O, Novak M
Journal of neuroinflammation 2010 Oct 12;7:64
Journal of neuroinflammation 2010 Oct 12;7:64
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT
The American journal of pathology 2010 Nov;177(5):2549-62
The American journal of pathology 2010 Nov;177(5):2549-62
Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.
Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, Colombo A, Borroni B, Vara H, Dell'Agli M, Cattabeni F, Giustetto M, Borsello T, Forloni G, Padovani A, Di Luca M
Brain : a journal of neurology 2010 Nov;133(11):3323-35
Brain : a journal of neurology 2010 Nov;133(11):3323-35
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.
Blanchard J, Wanka L, Tung YC, Cárdenas-Aguayo Mdel C, LaFerla FM, Iqbal K, Grundke-Iqbal I
Acta neuropathologica 2010 Nov;120(5):605-21
Acta neuropathologica 2010 Nov;120(5):605-21
Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.
Rosario ER, Carroll J, Pike CJ
Brain research 2010 Nov 4;1359:281-90
Brain research 2010 Nov 4;1359:281-90
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
Tamayev R, Giliberto L, Li W, d'Abramo C, Arancio O, Vidal R, D'Adamio L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Nov 3;30(44):14915-24
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Nov 3;30(44):14915-24
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Bittner T, Fuhrmann M, Burgold S, Ochs SM, Hoffmann N, Mitteregger G, Kretzschmar H, LaFerla FM, Herms J
PloS one 2010 Nov 16;5(11):e15477
PloS one 2010 Nov 16;5(11):e15477
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Höftberger R, Fink S, Aboul-Enein F, Botond G, Olah J, Berki T, Ovadi J, Lassmann H, Budka H, Kovacs GG
Glia 2010 Nov 15;58(15):1847-57
Glia 2010 Nov 15;58(15):1847-57
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Giménez-Llort L, Botana LM
Cellular and molecular neurobiology 2010 May;30(4):577-90
Cellular and molecular neurobiology 2010 May;30(4):577-90
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.
Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ
Experimental & molecular medicine 2010 May 31;42(5):386-94
Experimental & molecular medicine 2010 May 31;42(5):386-94
Acute hypoxia promote the phosphorylation of tau via ERK pathway.
Fang H, Zhang LF, Meng FT, Du X, Zhou JN
Neuroscience letters 2010 May 3;474(3):173-7
Neuroscience letters 2010 May 3;474(3):173-7
Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.
Dickstein DL, Brautigam H, Stockton SD Jr, Schmeidler J, Hof PR
Brain structure & function 2010 Mar;214(2-3):161-79
Brain structure & function 2010 Mar;214(2-3):161-79
Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy.
Soontornniyomkij V, Lynch MD, Mermash S, Pomakian J, Badkoobehi H, Clare R, Vinters HV
Brain pathology (Zurich, Switzerland) 2010 Mar;20(2):459-67
Brain pathology (Zurich, Switzerland) 2010 Mar;20(2):459-67
Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.
Escribano L, Simón AM, Gimeno E, Cuadrado-Tejedor M, López de Maturana R, García-Osta A, Ricobaraza A, Pérez-Mediavilla A, Del Río J, Frechilla D
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010 Jun;35(7):1593-604
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010 Jun;35(7):1593-604
Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker.
Khan TK, Alkon DL
Neurobiology of aging 2010 Jun;31(6):889-900
Neurobiology of aging 2010 Jun;31(6):889-900
Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.
Carroll JC, Rosario ER, Villamagna A, Pike CJ
Endocrinology 2010 Jun;151(6):2713-22
Endocrinology 2010 Jun;151(6):2713-22
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.
Del Tredici K, Hawkes CH, Ghebremedhin E, Braak H
Acta neuropathologica 2010 Jun;119(6):703-13
Acta neuropathologica 2010 Jun;119(6):703-13
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Bertrand J, Plouffe V, Sénéchal P, Leclerc N
Neuroscience 2010 Jun 30;168(2):323-34
Neuroscience 2010 Jun 30;168(2):323-34
Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK
Neurobiology of aging 2010 Jul;31(7):1145-52
Neurobiology of aging 2010 Jul;31(7):1145-52
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Koike MA, Green KN, Blurton-Jones M, Laferla FM
The American journal of pathology 2010 Jul;177(1):300-10
The American journal of pathology 2010 Jul;177(1):300-10
Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord.
Braak H, Ludolph A, Thal DR, Del Tredici K
Acta neuropathologica 2010 Jul;120(1):67-74
Acta neuropathologica 2010 Jul;120(1):67-74
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
Bigio EH, Mishra M, Hatanpaa KJ, White CL 3rd, Johnson N, Rademaker A, Weitner BB, Deng HX, Dubner SD, Weintraub S, Mesulam M
Acta neuropathologica 2010 Jul;120(1):43-54
Acta neuropathologica 2010 Jul;120(1):43-54
A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity.
Poorkaj P, Raskind WH, Leverenz JB, Matsushita M, Zabetian CP, Samii A, Kim S, Gazi N, Nutt JG, Wolff J, Yearout D, Greenup JL, Steinbart EJ, Bird TD
Movement disorders : official journal of the Movement Disorder Society 2010 Jul 30;25(10):1409-17
Movement disorders : official journal of the Movement Disorder Society 2010 Jul 30;25(10):1409-17
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.
Feuillette S, Deramecourt V, Laquerriere A, Duyckaerts C, Delisle MB, Maurage CA, Blum D, Buée L, Frébourg T, Campion D, Lecourtois M
Brain research 2010 Jul 23;1345:182-9
Brain research 2010 Jul 23;1345:182-9
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB
PLoS genetics 2010 Jul 15;6(7):e1001026
PLoS genetics 2010 Jul 15;6(7):e1001026
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease.
Josephs KA, Whitwell JL, Boeve BF, Knopman DS, Petersen RC, Hu WT, Parisi JE, Dickson DW, Jack CR Jr
Movement disorders : official journal of the Movement Disorder Society 2010 Jul 15;25(9):1246-52
Movement disorders : official journal of the Movement Disorder Society 2010 Jul 15;25(9):1246-52
In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
Härtig W, Kacza J, Paulke BR, Grosche J, Bauer U, Hoffmann A, Elsinghorst PW, Gütschow M
The European journal of neuroscience 2010 Jan;31(1):99-109
The European journal of neuroscience 2010 Jan;31(1):99-109
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.
Capucchio MT, Márquez M, Pregel P, Foradada L, Bravo M, Mattutino G, Torre C, Schiffer D, Catalano D, Valenza F, Guarda F, Pumarola M
Journal of comparative pathology 2010 Jan;142(1):61-73
Journal of comparative pathology 2010 Jan;142(1):61-73
Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.
Lecanu L, Rammouz G, McCourty A, Sidahmed EK, Greeson J, Papadopoulos V
Neuroscience 2010 Jan 20;165(2):427-35
Neuroscience 2010 Jan 20;165(2):427-35
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.
Pan-Montojo F, Anichtchik O, Dening Y, Knels L, Pursche S, Jung R, Jackson S, Gille G, Spillantini MG, Reichmann H, Funk RH
PloS one 2010 Jan 19;5(1):e8762
PloS one 2010 Jan 19;5(1):e8762
Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5.
Lopes JP, Oliveira CR, Agostinho P
Aging cell 2010 Feb;9(1):64-77
Aging cell 2010 Feb;9(1):64-77
Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.
Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group
Neuropathology and applied neurobiology 2010 Feb;36(1):25-40
Neuropathology and applied neurobiology 2010 Feb;36(1):25-40
Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.
Lee JK, Jin HK, Endo S, Schuchman EH, Carter JE, Bae JS
Stem cells (Dayton, Ohio) 2010 Feb;28(2):329-43
Stem cells (Dayton, Ohio) 2010 Feb;28(2):329-43
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM
The American journal of pathology 2010 Feb;176(2):870-80
The American journal of pathology 2010 Feb;176(2):870-80
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.
Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J
PloS one 2010 Feb 2;5(2):e9002
PloS one 2010 Feb 2;5(2):e9002
Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ
Neuropathology : official journal of the Japanese Society of Neuropathology 2010 Dec;30(6):574-9
Neuropathology : official journal of the Japanese Society of Neuropathology 2010 Dec;30(6):574-9
Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.
Loy CT, McCusker E, Kril JJ, Kwok JB, Brooks WS, McCann H, Isaacs AM, Halliday GM
Brain : a journal of neurology 2010 Dec;133(Pt 12):e158; author reply e159
Brain : a journal of neurology 2010 Dec;133(Pt 12):e158; author reply e159
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.
Boutajangout A, Quartermain D, Sigurdsson EM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 8;30(49):16559-66
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 8;30(49):16559-66
DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease.
Chen J, Cohen ML, Lerner AJ, Yang Y, Herrup K
Molecular neurodegeneration 2010 Dec 20;5:60
Molecular neurodegeneration 2010 Dec 20;5:60
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.
Colodner KJ, Feany MB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 1;30(48):16102-13
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 1;30(48):16102-13
Isolated bulbar paralysis in a patient with medullar tau pathology: a case report.
Pretnar-Oblak J, Zaletel M, Hajnsek TM, Meglic B, Hocevar-Boltezar I, Popovic M
Journal of neurology, neurosurgery, and psychiatry 2010 Aug;81(8):847-9
Journal of neurology, neurosurgery, and psychiatry 2010 Aug;81(8):847-9
Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models.
Nicholson RM, Kusne Y, Nowak LA, LaFerla FM, Reiman EM, Valla J
Brain research 2010 Aug 6;1347:179-85
Brain research 2010 Aug 6;1347:179-85
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Götz J, Ittner LM
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 3;107(31):13888-93
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 3;107(31):13888-93
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Mohorko N, Repovs G, Popović M, Kovacs GG, Bresjanac M
Journal of neuropathology and experimental neurology 2010 Apr;69(4):405-14
Journal of neuropathology and experimental neurology 2010 Apr;69(4):405-14
Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi.
Caltagarone J, Hamilton RL, Murdoch G, Jing Z, DeFranco DB, Bowser R
Journal of neuropathology and experimental neurology 2010 Apr;69(4):356-71
Journal of neuropathology and experimental neurology 2010 Apr;69(4):356-71
Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.
Maj M, Gartner W, Ilhan A, Neziri D, Attems J, Wagner L
The Journal of endocrinology 2010 Apr;205(1):25-36
The Journal of endocrinology 2010 Apr;205(1):25-36
Caspase activation precedes and leads to tangles.
de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT
Nature 2010 Apr 22;464(7292):1201-4
Nature 2010 Apr 22;464(7292):1201-4
Hyposmia in progressive supranuclear palsy.
Silveira-Moriyama L, Hughes G, Church A, Ayling H, Williams DR, Petrie A, Holton J, Revesz T, Kingsbury A, Morris HR, Burn DJ, Lees AJ
Movement disorders : official journal of the Movement Disorder Society 2010 Apr 15;25(5):570-7
Movement disorders : official journal of the Movement Disorder Society 2010 Apr 15;25(5):570-7
Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases.
Wang GR, Shi S, Gao C, Zhang BY, Tian C, Dong CF, Zhou RM, Li XL, Chen C, Han J, Dong XP
BMC infectious diseases 2010 Apr 1;10:86
BMC infectious diseases 2010 Apr 1;10:86
Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.
Campos-Peña V, Tapia-Ramírez J, Sánchez-Torres C, Meraz-Rios MA
Journal of Alzheimer's disease : JAD 2009;18(4):919-33
Journal of Alzheimer's disease : JAD 2009;18(4):919-33
Altered subcellular distribution of c-Abl in Alzheimer's disease.
Jing Z, Caltagarone J, Bowser R
Journal of Alzheimer's disease : JAD 2009;17(2):409-22
Journal of Alzheimer's disease : JAD 2009;17(2):409-22
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
Capsoni S, Covaceuszach S, Ugolini G, Spirito F, Vignone D, Stefanini B, Amato G, Cattaneo A
Journal of Alzheimer's disease : JAD 2009;16(2):371-88
Journal of Alzheimer's disease : JAD 2009;16(2):371-88
Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration.
Filipcik P, Cente M, Krajciova G, Vanicky I, Novak M
Cellular and molecular neurobiology 2009 Sep;29(6-7):895-900
Cellular and molecular neurobiology 2009 Sep;29(6-7):895-900
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
Nogalska A, Terracciano C, D'Agostino C, King Engel W, Askanas V
Acta neuropathologica 2009 Sep;118(3):407-13
Acta neuropathologica 2009 Sep;118(3):407-13
TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.
Kovacs GG, Murrell JR, Horvath S, Haraszti L, Majtenyi K, Molnar MJ, Budka H, Ghetti B, Spina S
Movement disorders : official journal of the Movement Disorder Society 2009 Sep 15;24(12):1843-7
Movement disorders : official journal of the Movement Disorder Society 2009 Sep 15;24(12):1843-7
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.
McConnell GC, Rees HD, Levey AI, Gutekunst CA, Gross RE, Bellamkonda RV
Journal of neural engineering 2009 Oct;6(5):056003
Journal of neural engineering 2009 Oct;6(5):056003
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Wilhelmus MM, Grunberg SC, Bol JG, van Dam AM, Hoozemans JJ, Rozemuller AJ, Drukarch B
Brain pathology (Zurich, Switzerland) 2009 Oct;19(4):612-22
Brain pathology (Zurich, Switzerland) 2009 Oct;19(4):612-22
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
van Eersel J, Bi M, Ke YD, Hodges JR, Xuereb JH, Gregory GC, Halliday GM, Götz J, Kril JJ, Ittner LM
Journal of neural transmission (Vienna, Austria : 1996) 2009 Oct;116(10):1243-51
Journal of neural transmission (Vienna, Austria : 1996) 2009 Oct;116(10):1243-51
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.
Tang J, LeGros RP, Louneva N, Yeh L, Cohen JW, Hahn CG, Blake DJ, Arnold SE, Talbot K
Human molecular genetics 2009 Oct 15;18(20):3851-63
Human molecular genetics 2009 Oct 15;18(20):3851-63
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.
Whiteman IT, Gervasio OL, Cullen KM, Guillemin GJ, Jeong EV, Witting PK, Antao ST, Minamide LS, Bamburg JR, Goldsbury C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Oct 14;29(41):12994-3005
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Oct 14;29(41):12994-3005
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, Kauselmann G, Zevnik B, Henriksen G, Drzezga A, Pohlner J, Schoor M, Kemp JA, von der Kammer H
PloS one 2009 Nov 20;4(11):e7931
PloS one 2009 Nov 20;4(11):e7931
Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.
Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N
Journal of neuropathology and experimental neurology 2009 May;68(5):503-14
Journal of neuropathology and experimental neurology 2009 May;68(5):503-14
Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.
Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB, MRC-CFAS
Brain : a journal of neurology 2009 May;132(Pt 5):1324-34
Brain : a journal of neurology 2009 May;132(Pt 5):1324-34
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Greco SJ, Sarkar S, Casadesus G, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N
Neuroscience letters 2009 May 22;455(3):191-4
Neuroscience letters 2009 May 22;455(3):191-4
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Ohmi K, Kudo LC, Ryazantsev S, Zhao HZ, Karsten SL, Neufeld EF
Proceedings of the National Academy of Sciences of the United States of America 2009 May 19;106(20):8332-7
Proceedings of the National Academy of Sciences of the United States of America 2009 May 19;106(20):8332-7
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Ricobaraza A, Cuadrado-Tejedor M, Pérez-Mediavilla A, Frechilla D, Del Río J, García-Osta A
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009 Jun;34(7):1721-32
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009 Jun;34(7):1721-32
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jun 24;29(25):7957-65
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jun 24;29(25):7957-65
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA
Journal of neuropathology and experimental neurology 2009 Jul;68(7):709-35
Journal of neuropathology and experimental neurology 2009 Jul;68(7):709-35
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CC, Shaw PJ, Grierson AJ
Journal of neurochemistry 2009 Jul;110(1):34-44
Journal of neurochemistry 2009 Jul;110(1):34-44
Transmission and spreading of tauopathy in transgenic mouse brain.
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M
Nature cell biology 2009 Jul;11(7):909-13
Nature cell biology 2009 Jul;11(7):909-13
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
Sasaki K, Shimura H, Itaya M, Tanaka R, Mori H, Mizuno Y, Kosik KS, Tanaka S, Hattori N
FEBS letters 2009 Jul 7;583(13):2194-200
FEBS letters 2009 Jul 7;583(13):2194-200
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
Ittner LM, Ke YD, Götz J
The Journal of biological chemistry 2009 Jul 31;284(31):20909-16
The Journal of biological chemistry 2009 Jul 31;284(31):20909-16
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
Rahman A, Ting K, Cullen KM, Braidy N, Brew BJ, Guillemin GJ
PloS one 2009 Jul 22;4(7):e6344
PloS one 2009 Jul 22;4(7):e6344
A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau.
Brandt R, Gergou A, Wacker I, Fath T, Hutter H
Neurobiology of aging 2009 Jan;30(1):22-33
Neurobiology of aging 2009 Jan;30(1):22-33
Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.
Vidal R, Barbeito AG, Miravalle L, Ghetti B
Brain pathology (Zurich, Switzerland) 2009 Jan;19(1):58-68
Brain pathology (Zurich, Switzerland) 2009 Jan;19(1):58-68
Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.
Shehadeh L, Mitsi G, Adi N, Bishopric N, Papapetropoulos S
Movement disorders : official journal of the Movement Disorder Society 2009 Jan 30;24(2):204-10
Movement disorders : official journal of the Movement Disorder Society 2009 Jan 30;24(2):204-10
The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Lee HG, Zhu X, Casadesus G, Pallàs M, Camins A, O'Neill MJ, Nakanishi S, Perry G, Smith MA
Brain research 2009 Jan 16;1249:244-50
Brain research 2009 Jan 16;1249:244-50
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Chatterjee S, Sang TK, Lawless GM, Jackson GR
Human molecular genetics 2009 Jan 1;18(1):164-77
Human molecular genetics 2009 Jan 1;18(1):164-77
Rapidly progressive neurodegenerative dementias.
Josephs KA, Ahlskog JE, Parisi JE, Boeve BF, Crum BA, Giannini C, Petersen RC
Archives of neurology 2009 Feb;66(2):201-7
Archives of neurology 2009 Feb;66(2):201-7
Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease.
Sikorska B, Liberski PP, Sobów T, Budka H, Ironside JW
Neuropathology and applied neurobiology 2009 Feb;35(1):46-59
Neuropathology and applied neurobiology 2009 Feb;35(1):46-59
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
Ojala J, Alafuzoff I, Herukka SK, van Groen T, Tanila H, Pirttilä T
Neurobiology of aging 2009 Feb;30(2):198-209
Neurobiology of aging 2009 Feb;30(2):198-209
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Greco SJ, Sarkar S, Johnston JM, Tezapsidis N
Biochemical and biophysical research communications 2009 Feb 27;380(1):98-104
Biochemical and biophysical research communications 2009 Feb 27;380(1):98-104
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Aug;23(8):2595-604
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Aug;23(8):2595-604
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG
Aging 2009 Apr;1(4):382-8
Aging 2009 Apr;1(4):382-8
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG
Aging 2009 Apr;1(4):382-8
Aging 2009 Apr;1(4):382-8
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Bitner RS, Nikkel AL, Markosyan S, Otte S, Puttfarcken P, Gopalakrishnan M
Brain research 2009 Apr 10;1265:65-74
Brain research 2009 Apr 10;1265:65-74
Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels.
Schrag M, Sharma S, Brown-Borg H, Ghribi O
Hippocampus 2008;18(3):239-44
Hippocampus 2008;18(3):239-44
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Laporte V, Ait-Ghezala G, Volmar CH, Ganey C, Ganey N, Wood M, Mullan M
Brain research 2008 Sep 22;1231:132-42
Brain research 2008 Sep 22;1231:132-42
Age and apoE associations with complex pathologic features in Alzheimer's disease.
Jicha GA, Parisi JE, Dickson DW, Cha RH, Johnson KA, Smith GE, Boeve BF, Petersen RC, Knopman DS
Journal of the neurological sciences 2008 Oct 15;273(1-2):34-9
Journal of the neurological sciences 2008 Oct 15;273(1-2):34-9
Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice.
Rodríguez-Navarro JA, Gómez A, Rodal I, Perucho J, Martinez A, Furió V, Ampuero I, Casarejos MJ, Solano RM, de Yébenes JG, Mena MA
Human molecular genetics 2008 Oct 15;17(20):3128-43
Human molecular genetics 2008 Oct 15;17(20):3128-43
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Nov 26;28(48):12798-807
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Nov 26;28(48):12798-807
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP
The Journal of clinical investigation 2008 May;118(5):1877-89
The Journal of clinical investigation 2008 May;118(5):1877-89
Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation.
Hinners I, Hill A, Otto U, Michalsky A, Mack TG, Striggow F
Molecular and cellular neurosciences 2008 Mar;37(3):559-67
Molecular and cellular neurosciences 2008 Mar;37(3):559-67
Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease.
Patil S, Balu D, Melrose J, Chan C
BMC research notes 2008 Jun 4;1:20
BMC research notes 2008 Jun 4;1:20
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca FL, Catania M, Di Fede G, Mangieri M, Giaccone G, Croci D, Tagliavini F
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca FL, Catania M, Di Fede G, Mangieri M, Giaccone G, Croci D, Tagliavini F
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation.
Resende R, Ferreiro E, Pereira C, Oliveira CR
Journal of neuroscience research 2008 Jul;86(9):2091-9
Journal of neuroscience research 2008 Jul;86(9):2091-9
MAPT S305I mutation: implications for argyrophilic grain disease.
Kovacs GG, Pittman A, Revesz T, Luk C, Lees A, Kiss E, Tariska P, Laszlo L, Molnár K, Molnar MJ, Tolnay M, de Silva R
Acta neuropathologica 2008 Jul;116(1):103-18
Acta neuropathologica 2008 Jul;116(1):103-18
Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
Thakur A, Siedlak SL, James SL, Bonda DJ, Rao A, Webber KM, Camins A, Pallàs M, Casadesus G, Lee HG, Bowser R, Raina AK, Perry G, Smith MA, Zhu X
International journal of clinical and experimental pathology 2008 Jan 1;1(2):134-46
International journal of clinical and experimental pathology 2008 Jan 1;1(2):134-46
Beta-amyloid burden is not associated with rates of brain atrophy.
Josephs KA, Whitwell JL, Ahmed Z, Shiung MM, Weigand SD, Knopman DS, Boeve BF, Parisi JE, Petersen RC, Dickson DW, Jack CR Jr
Annals of neurology 2008 Feb;63(2):204-12
Annals of neurology 2008 Feb;63(2):204-12
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, Vitek MP, Colton CA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Feb 13;28(7):1537-45
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Feb 13;28(7):1537-45
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG
Age (Dordrecht, Netherlands) 2008 Dec;30(4):209-15
Age (Dordrecht, Netherlands) 2008 Dec;30(4):209-15
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
Liu Y, Yoo MJ, Savonenko A, Stirling W, Price DL, Borchelt DR, Mamounas L, Lyons WE, Blue ME, Lee MK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 17;28(51):13805-14
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 17;28(51):13805-14
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.
Matsuoka Y, Jouroukhin Y, Gray AJ, Ma L, Hirata-Fukae C, Li HF, Feng L, Lecanu L, Walker BR, Planel E, Arancio O, Gozes I, Aisen PS
The Journal of pharmacology and experimental therapeutics 2008 Apr;325(1):146-53
The Journal of pharmacology and experimental therapeutics 2008 Apr;325(1):146-53
Argyrophilic grains: a distinct disease or an additive pathology?
Josephs KA, Whitwell JL, Parisi JE, Knopman DS, Boeve BF, Geda YE, Jack CR Jr, Petersen RC, Dickson DW
Neurobiology of aging 2008 Apr;29(4):566-73
Neurobiology of aging 2008 Apr;29(4):566-73
Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice.
Bai F, Xi JH, Andley UP
Molecular vision 2007 Sep 6;13:1589-600
Molecular vision 2007 Sep 6;13:1589-600
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Preusser M, Kitzwoegerer M, Budka H, Brugger S
Neuropathology : official journal of the Japanese Society of Neuropathology 2007 Oct;27(5):453-6
Neuropathology : official journal of the Japanese Society of Neuropathology 2007 Oct;27(5):453-6
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Preusser M, Kitzwoegerer M, Budka H, Brugger S
Neuropathology : official journal of the Japanese Society of Neuropathology 2007 Oct;27(5):453-6
Neuropathology : official journal of the Japanese Society of Neuropathology 2007 Oct;27(5):453-6
Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia.
Munoz DG, Woulfe J, Kertesz A
Acta neuropathologica 2007 Oct;114(4):347-57
Acta neuropathologica 2007 Oct;114(4):347-57
Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline.
Piggott MA, Ballard CG, Rowan E, Holmes C, McKeith IG, Jaros E, Perry RH, Perry EK
Synapse (New York, N.Y.) 2007 Nov;61(11):903-11
Synapse (New York, N.Y.) 2007 Nov;61(11):903-11
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
Caccamo A, Oddo S, Tran LX, LaFerla FM
The American journal of pathology 2007 May;170(5):1669-75
The American journal of pathology 2007 May;170(5):1669-75
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Leverenz JB, Yu CE, Montine TJ, Steinbart E, Bekris LM, Zabetian C, Kwong LK, Lee VM, Schellenberg GD, Bird TD
Brain : a journal of neurology 2007 May;130(Pt 5):1360-74
Brain : a journal of neurology 2007 May;130(Pt 5):1360-74
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G
Proceedings of the National Academy of Sciences of the United States of America 2007 May 29;104(22):9511-6
Proceedings of the National Academy of Sciences of the United States of America 2007 May 29;104(22):9511-6
Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology.
Gelpi E, Preusser M, Bauer G, Budka H
Forensic science international 2007 May 24;168(2-3):177-82
Forensic science international 2007 May 24;168(2-3):177-82
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Evans TA, Raina AK, Delacourte A, Aprelikova O, Lee HG, Zhu X, Perry G, Smith MA
International journal of medical sciences 2007 May 12;4(3):140-5
International journal of medical sciences 2007 May 12;4(3):140-5
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Evans TA, Raina AK, Delacourte A, Aprelikova O, Lee HG, Zhu X, Perry G, Smith MA
International journal of medical sciences 2007 May 12;4(3):140-5
International journal of medical sciences 2007 May 12;4(3):140-5
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Magaki S, Raghavan R, Mueller C, Oberg KC, Vinters HV, Kirsch WM
Neuroscience letters 2007 May 11;418(1):72-6
Neuroscience letters 2007 May 11;418(1):72-6
Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.
Grudzien A, Shaw P, Weintraub S, Bigio E, Mash DC, Mesulam MM
Neurobiology of aging 2007 Mar;28(3):327-35
Neurobiology of aging 2007 Mar;28(3):327-35
Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors.
Papapetropoulos S, Mash DC
Journal of neural transmission (Vienna, Austria : 1996) 2007 Mar;114(3):341-5
Journal of neural transmission (Vienna, Austria : 1996) 2007 Mar;114(3):341-5
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau LF, Duff KE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Mar 21;27(12):3090-7
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Mar 21;27(12):3090-7
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G
Journal of neuropathology and experimental neurology 2007 Jun;66(6):525-32
Journal of neuropathology and experimental neurology 2007 Jun;66(6):525-32
Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.
Leschik J, Welzel A, Weissmann C, Eckert A, Brandt R
Journal of neurochemistry 2007 Jun;101(5):1303-15
Journal of neurochemistry 2007 Jun;101(5):1303-15
Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
Rissman RA, Lee KF, Vale W, Sawchenko PE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Jun 13;27(24):6552-62
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Jun 13;27(24):6552-62
Insular pathology in Parkinson's disease patients with orthostatic hypotension.
Papapetropoulos S, Mash DC
Parkinsonism & related disorders 2007 Jul;13(5):308-11
Parkinsonism & related disorders 2007 Jul;13(5):308-11
Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
Dias-Santagata D, Fulga TA, Duttaroy A, Feany MB
The Journal of clinical investigation 2007 Jan;117(1):236-45
The Journal of clinical investigation 2007 Jan;117(1):236-45
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Josephs KA, Ahmed Z, Katsuse O, Parisi JF, Boeve BF, Knopman DS, Petersen RC, Davies P, Duara R, Graff-Radford NR, Uitti RJ, Rademakers R, Adamson J, Baker M, Hutton ML, Dickson DW
Journal of neuropathology and experimental neurology 2007 Feb;66(2):142-51
Journal of neuropathology and experimental neurology 2007 Feb;66(2):142-51
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.
Sikorska B, Papierz W, Preusser M, Liberski PP, Budka H
Neuropathology and applied neurobiology 2007 Feb;33(1):126-9
Neuropathology and applied neurobiology 2007 Feb;33(1):126-9
Inflammatory changes parallel the early stages of Alzheimer disease.
Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW
Neurobiology of aging 2007 Dec;28(12):1821-33
Neurobiology of aging 2007 Dec;28(12):1821-33
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, Yu WH, Luchsinger JA, Wadzinski B, Duff KE, Takashima A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Dec 12;27(50):13635-48
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Dec 12;27(50):13635-48
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM
Journal of neurochemistry 2007 Aug;102(4):1053-63
Journal of neurochemistry 2007 Aug;102(4):1053-63
Rates of cerebral atrophy differ in different degenerative pathologies.
Whitwell JL, Jack CR Jr, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Ferman TJ, Dickson DW, Josephs KA
Brain : a journal of neurology 2007 Apr;130(Pt 4):1148-58
Brain : a journal of neurology 2007 Apr;130(Pt 4):1148-58
Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia.
Piggott MA, Ballard CG, Dickinson HO, McKeith IG, Perry RH, Perry EK
The international journal of neuropsychopharmacology 2007 Apr;10(2):231-44
The international journal of neuropsychopharmacology 2007 Apr;10(2):231-44
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr 18;27(16):4385-95
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr 18;27(16):4385-95
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.
Ikonomovic MD, Abrahamson EE, Isanski BA, Debnath ML, Mathis CA, Dekosky ST, Klunk WE
Methods in enzymology 2006;412:123-44
Methods in enzymology 2006;412:123-44
Cognitive impairment and celiac disease.
Hu WT, Murray JA, Greenaway MC, Parisi JE, Josephs KA
Archives of neurology 2006 Oct;63(10):1440-6
Archives of neurology 2006 Oct;63(10):1440-6
Tau interacts with Golgi membranes and mediates their association with microtubules.
Farah CA, Perreault S, Liazoghli D, Desjardins M, Anton A, Lauzon M, Paiement J, Leclerc N
Cell motility and the cytoskeleton 2006 Nov;63(11):710-24
Cell motility and the cytoskeleton 2006 Nov;63(11):710-24
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Boeve BF, Baker M, Dickson DW, Parisi JE, Giannini C, Josephs KA, Hutton M, Pickering-Brown SM, Rademakers R, Tang-Wai D, Jack CR Jr, Kantarci K, Shiung MM, Golde T, Smith GE, Geda YE, Knopman DS, Petersen RC
Brain : a journal of neurology 2006 Nov;129(Pt 11):3103-14
Brain : a journal of neurology 2006 Nov;129(Pt 11):3103-14
Memory complaints are related to Alzheimer disease pathology in older persons.
Barnes LL, Schneider JA, Boyle PA, Bienias JL, Bennett DA
Neurology 2006 Nov 14;67(9):1581-5
Neurology 2006 Nov 14;67(9):1581-5
Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.
Jicha GA, Parisi JE, Dickson DW, Johnson K, Cha R, Ivnik RJ, Tangalos EG, Boeve BF, Knopman DS, Braak H, Petersen RC
Archives of neurology 2006 May;63(5):674-81
Archives of neurology 2006 May;63(5):674-81
Neuropathologic features of amnestic mild cognitive impairment.
Petersen RC, Parisi JE, Dickson DW, Johnson KA, Knopman DS, Boeve BF, Jicha GA, Ivnik RJ, Smith GE, Tangalos EG, Braak H, Kokmen E
Archives of neurology 2006 May;63(5):665-72
Archives of neurology 2006 May;63(5):665-72
Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations.
Papapetropoulos S, McCorquodale DS, Gonzalez J, Jean-Gilles L, Mash DC
Parkinsonism & related disorders 2006 May;12(4):253-6
Parkinsonism & related disorders 2006 May;12(4):253-6
Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension.
Oka T, Tamada Y, Nakajima E, Shearer TR, Azuma M
Journal of neuroscience research 2006 May 15;83(7):1342-51
Journal of neuroscience research 2006 May 15;83(7):1342-51
A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.
Blain JF, Sullivan PM, Poirier J
Neurobiology of disease 2006 Mar;21(3):505-14
Neurobiology of disease 2006 Mar;21(3):505-14
Neuropathology in the S305S tau gene mutation.
Halliday GM, Song YJ, Creasey H, Morris JG, Brooks WS, Kril JJ
Brain : a journal of neurology 2006 Mar;129(Pt 3):E40
Brain : a journal of neurology 2006 Mar;129(Pt 3):E40
Interleukin-1 mediates Alzheimer and Lewy body pathologies.
Griffin WS, Liu L, Li Y, Mrak RE, Barger SW
Journal of neuroinflammation 2006 Mar 16;3:5
Journal of neuroinflammation 2006 Mar 16;3:5
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment.
Jicha GA, Petersen RC, Knopman DS, Boeve BF, Smith GE, Geda YE, Johnson KA, Cha R, Delucia MW, Braak H, Dickson DW, Parisi JE
Journal of neuropathology and experimental neurology 2006 Jun;65(6):602-9
Journal of neuropathology and experimental neurology 2006 Jun;65(6):602-9
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
Quintana C, Bellefqih S, Laval JY, Guerquin-Kern JL, Wu TD, Avila J, Ferrer I, Arranz R, Patiño C
Journal of structural biology 2006 Jan;153(1):42-54
Journal of structural biology 2006 Jan;153(1):42-54
Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
Lee HG, Ueda M, Zhu X, Perry G, Smith MA
Journal of neuroscience research 2006 Dec;84(8):1856-61
Journal of neuroscience research 2006 Dec;84(8):1856-61
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
Wahle T, Thal DR, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, Heneka MT, Walter J
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Dec 6;26(49):12838-46
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Dec 6;26(49):12838-46
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM
The Journal of biological chemistry 2006 Dec 22;281(51):39413-23
The Journal of biological chemistry 2006 Dec 22;281(51):39413-23
Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits.
Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ
Journal of feline medicine and surgery 2006 Aug;8(4):234-42
Journal of feline medicine and surgery 2006 Aug;8(4):234-42
High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus.
Ghribi O, Larsen B, Schrag M, Herman MM
Experimental neurology 2006 Aug;200(2):460-7
Experimental neurology 2006 Aug;200(2):460-7
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.
Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Aug 30;26(35):9047-56
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Aug 30;26(35):9047-56
Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation.
Sakaue M, Okazaki M, Hara S
Toxicology 2005 Sep 15;213(1-2):97-106
Toxicology 2005 Sep 15;213(1-2):97-106
A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
Obici L, Demarchi A, de Rosa G, Bellotti V, Marciano S, Donadei S, Arbustini E, Palladini G, Diegoli M, Genovese E, Ferrari G, Coverlizza S, Merlini G
Annals of neurology 2005 Oct;58(4):639-44
Annals of neurology 2005 Oct;58(4):639-44
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.
Klos KJ, Josephs KA, Parisi JE, Dickson DW
Movement disorders : official journal of the Movement Disorder Society 2005 Nov;20(11):1515-20
Movement disorders : official journal of the Movement Disorder Society 2005 Nov;20(11):1515-20
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Yang W, Ang LC, Strong MJ
Brain research. Developmental brain research 2005 May 12;156(2):127-38
Brain research. Developmental brain research 2005 May 12;156(2):127-38
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Yang W, Ang LC, Strong MJ
Brain research. Developmental brain research 2005 May 12;156(2):127-38
Brain research. Developmental brain research 2005 May 12;156(2):127-38
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Hung KS, Hwang SL, Liang CL, Chen YJ, Lee TH, Liu JK, Howng SL, Wang CH
Journal of neuropathology and experimental neurology 2005 Jan;64(1):15-26
Journal of neuropathology and experimental neurology 2005 Jan;64(1):15-26
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Hung KS, Hwang SL, Liang CL, Chen YJ, Lee TH, Liu JK, Howng SL, Wang CH
Journal of neuropathology and experimental neurology 2005 Jan;64(1):15-26
Journal of neuropathology and experimental neurology 2005 Jan;64(1):15-26
Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates.
Fukuda T, Shimizu J, Furuhata H, Abe T, Shimizu K, Oishi T, Ogihara M, Kubota J, Sasaki A, Sasaki K, Azuma T, Umemura S
Acta neuropathologica 2005 Aug;110(2):145-50
Acta neuropathologica 2005 Aug;110(2):145-50
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.
Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E
Acta neuropathologica 2005 Aug;110(2):135-44
Acta neuropathologica 2005 Aug;110(2):135-44
Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons.
Patil S, Chan C
Neuroscience letters 2005 Aug 26;384(3):288-93
Neuroscience letters 2005 Aug 26;384(3):288-93
Antemortem diagnosis of frontotemporal lobar degeneration.
Knopman DS, Boeve BF, Parisi JE, Dickson DW, Smith GE, Ivnik RJ, Josephs KA, Petersen RC
Annals of neurology 2005 Apr;57(4):480-8
Annals of neurology 2005 Apr;57(4):480-8
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Frasier M, Walzer M, McCarthy L, Magnuson D, Lee JM, Haas C, Kahle P, Wolozin B
Experimental neurology 2005 Apr;192(2):274-87
Experimental neurology 2005 Apr;192(2):274-87
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y
The Journal of biological chemistry 2004 Oct 22;279(43):44795-801
The Journal of biological chemistry 2004 Oct 22;279(43):44795-801
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Mar 10;24(10):2527-34
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Mar 10;24(10):2527-34
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
Mesulam M, Shaw P, Mash D, Weintraub S
Annals of neurology 2004 Jun;55(6):815-28
Annals of neurology 2004 Jun;55(6):815-28
Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease.
Heckmann JM, Low WC, de Villiers C, Rutherfoord S, Vorster A, Rao H, Morris CM, Ramesar RS, Kalaria RN
Brain : a journal of neurology 2004 Jan;127(Pt 1):133-42
Brain : a journal of neurology 2004 Jan;127(Pt 1):133-42
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.
Shimura H, Schwartz D, Gygi SP, Kosik KS
The Journal of biological chemistry 2004 Feb 6;279(6):4869-76
The Journal of biological chemistry 2004 Feb 6;279(6):4869-76
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Vidal R, Ghetti B, Takao M, Brefel-Courbon C, Uro-Coste E, Glazier BS, Siani V, Benson MD, Calvas P, Miravalle L, Rascol O, Delisle MB
Journal of neuropathology and experimental neurology 2004 Apr;63(4):363-80
Journal of neuropathology and experimental neurology 2004 Apr;63(4):363-80
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Vidal R, Ghetti B, Takao M, Brefel-Courbon C, Uro-Coste E, Glazier BS, Siani V, Benson MD, Calvas P, Miravalle L, Rascol O, Delisle MB
Journal of neuropathology and experimental neurology 2004 Apr;63(4):363-80
Journal of neuropathology and experimental neurology 2004 Apr;63(4):363-80
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Lee HG, Ogawa O, Zhu X, O'Neill MJ, Petersen RB, Castellani RJ, Ghanbari H, Perry G, Smith MA
Acta neuropathologica 2004 Apr;107(4):365-71
Acta neuropathologica 2004 Apr;107(4):365-71
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.
Shimura H, Miura-Shimura Y, Kosik KS
The Journal of biological chemistry 2004 Apr 23;279(17):17957-62
The Journal of biological chemistry 2004 Apr 23;279(17):17957-62
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
Li G, Yin H, Kuret J
The Journal of biological chemistry 2004 Apr 16;279(16):15938-45
The Journal of biological chemistry 2004 Apr 16;279(16):15938-45
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10966-71
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10966-71
Neuropathology of cognitively normal elderly.
Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC
Journal of neuropathology and experimental neurology 2003 Nov;62(11):1087-95
Journal of neuropathology and experimental neurology 2003 Nov;62(11):1087-95
Neuropathology of cognitively normal elderly.
Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC
Journal of neuropathology and experimental neurology 2003 Nov;62(11):1087-95
Journal of neuropathology and experimental neurology 2003 Nov;62(11):1087-95
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Tang-Wai DF, Josephs KA, Boeve BF, Petersen RC, Parisi JE, Dickson DW
Journal of neurology, neurosurgery, and psychiatry 2003 Mar;74(3):389
Journal of neurology, neurosurgery, and psychiatry 2003 Mar;74(3):389
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Tang-Wai DF, Josephs KA, Boeve BF, Petersen RC, Parisi JE, Dickson DW
Journal of neurology, neurosurgery, and psychiatry 2003 Mar;74(3):389
Journal of neurology, neurosurgery, and psychiatry 2003 Mar;74(3):389
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Zhu X, Sun Z, Lee HG, Siedlak SL, Perry G, Smith MA
Journal of neurochemistry 2003 Jul;86(1):136-42
Journal of neurochemistry 2003 Jul;86(1):136-42
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Zhu X, Sun Z, Lee HG, Siedlak SL, Perry G, Smith MA
Journal of neurochemistry 2003 Jul;86(1):136-42
Journal of neurochemistry 2003 Jul;86(1):136-42
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex.
Agarwal-Mawal A, Qureshi HY, Cafferty PW, Yuan Z, Han D, Lin R, Paudel HK
The Journal of biological chemistry 2003 Apr 11;278(15):12722-8
The Journal of biological chemistry 2003 Apr 11;278(15):12722-8
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Yoshida H, Goedert M
Biochemistry 2002 Dec 24;41(51):15203-11
Biochemistry 2002 Dec 24;41(51):15203-11
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Yoshida H, Goedert M
Biochemistry 2002 Dec 24;41(51):15203-11
Biochemistry 2002 Dec 24;41(51):15203-11
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Sep 1;21(17):6758-71
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Sep 1;21(17):6758-71
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Sep 1;21(17):6758-71
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Sep 1;21(17):6758-71
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW
Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 17;98(15):8838-43
Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 17;98(15):8838-43
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA
Mechanisms of ageing and development 2001 Dec;123(1):39-46
Mechanisms of ageing and development 2001 Dec;123(1):39-46
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA
Mechanisms of ageing and development 2001 Dec;123(1):39-46
Mechanisms of ageing and development 2001 Dec;123(1):39-46
Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments.
King ME, Ghoshal N, Wall JS, Binder LI, Ksiezak-Reding H
The American journal of pathology 2001 Apr;158(4):1481-90
The American journal of pathology 2001 Apr;158(4):1481-90
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
Braak E, Braak H, Mandelkow EM
Acta neuropathologica 1994;87(6):554-67
Acta neuropathologica 1994;87(6):554-67
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
Braak E, Braak H, Mandelkow EM
Acta neuropathologica 1994;87(6):554-67
Acta neuropathologica 1994;87(6):554-67
Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes.
Mercken M, Vandermeeren M, Lübke U, Six J, Boons J, Van de Voorde A, Martin JJ, Gheuens J
Acta neuropathologica 1992;84(3):265-72
Acta neuropathologica 1992;84(3):265-72
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- Fig 11 Intranasally administered midi-GAGR increased neuronal activity markers and decreased hyperphosphorylated tau in 3xTg-AD mice. (A) 12-week-old 3xTg-AD mice were intranasally administered with 40 muL (20 muL/nostril) of either sterile H 2 O (Veh.) or 1 mM midi-GAGR (midi) every day for 14 days and processed to obtain the cortex and hippocampus (Hippo). The tissues were homogenized to extract proteins for immunoblotting using the antibodies to NF200, GAP-43, PSD95, synaptophysin, pCREB, CREB, p-tau (AT8), tau, and GAPDH. (B-J) The densities of protein bands were measured using Image J and normalized to that of the loading control, GAPDH. Normalized values were used to calculate the average normalized band densities of NF200 (B), GAP-43 (C), PSD95 (D), synaptophysin (SYN, E), pCREB (F), total CREB (G), p-tau (H), and total tau (I). Data represent mean +- SEM of three independent animals. #, p
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- Figure 6 Changes in axon transport are accompanied by increased expression of phosphorylated p38 MAPK and downstream Hsp27, but not Tau. ( a ) Immunolocalization of phosphorylated p38 MAPK (p-p38 MAPK; magenta), in retinas from the 48-h post-CTB injection transport studies, revealed increased expression in eyes treated with sVEGFR-2 (right panels), in comparison with IgG 1 controls (left panels). Original magnification= x 10; green=CTB, blue=DAPI. Higher magnification ( x 40) images (left middle and right) showing elevated p-p38 MAPK as well as nuclear localization in some cells (arrows) in sVEGFR-2 treated retinas. ( b ) Differences in expression of phosphorylated Hsp27 were also observed between IgG 1 (left panels) and sVEGFR-2 (left panels) treatment. Phosphorylated Hsp27 (green) was strongly upregulated following sVEGFR-2 administration, and colocalized with GFAP (red), 41 indicating astrocyte expression. Blue=DAPI. Left and right middle panels - original magnification= x 10; left middle and right panels - original magnification= x 40. ( c ) In contrast, no changes were detected in phosphorylated Tau levels between IgG 1 (left panels) and sVEGFR-2 (right panels). Red=p-Tau, green=CTB, blue=DAPI. Original magnifications= x 10 (left and right middle) and x 40 (left middle and right)
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- Fig. 1 Tau and Abeta pathologies in the 5xFAD/AAV-tau mouse model. a Representative image of the distribution of Abeta (4G8, in green) and human tau (HT7, in red) in the hippocampal formation of 5xFAD/AAV-tau mice. b , c Higher magnification image in the ipsilateral ( b ) and contralateral CA3 ( c ). d Percentage of the total hippocampal area covered by HT7 staining in the ipsi- and contralateral hippocampus, in WT/AAV-tau and 5xFAD/AAV-tau mice. e Representative image of the distribution of Abeta (4G8, in green) and Ser202/Thr205 phospho-tau immunoreactivity (AT8, in red) in the hippocampus of 5xFAD/AAV-tau mice. f , g Higher magnification image in the ipsilateral ( f ) and contralateral CA3 ( g ). Note that in the ipsilateral hippocampus, AT8-positive tau is mainly located in the soma and neurites of neuronal cells. In the contralateral hippocampus, AT8-positive tau puncta (arrowheads) are mainly located near amyloid plaques (4G8, in green). h Percentage of the hippocampal surface covered by AT8 phospho-tau immunoreactivity in the ipsilateral hippocampus, comparing WT/AAV-tau and 5xFAD/AAV-tau mice. i Percentage of the surface covered by AT8 phospho-tau immunoreactivity in the contralateral hippocampus. Note the significant coverage increase in the 5xFAD/AAV-tau mice, which reflects the presence of phospho-tau-positive neuritic puncta. Scale bars: 800 um ( a , e ) and 100 um ( b , c , f , g ). Statistical analysis: unpaired two-tailed Student's t-test, **** p < 0.0001; WT/A
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- FIGURE 6 The effect of miR-195 on the expression of APP, BACE-1, AT8 protein in the hippocampi of APP/PS1 mice after Lv-pre -miR-195 injection for 2M (A) MiR-195 down-regulated the expression of APP protein in hippocampus but did not affect it on temporal lobe cortex of APP/PS1 mice. * p < 0.05 vs. WT. # p < 0.05 vs. Lv-NC (B) There was no significant change in BACE-1 protein in hippocampus and temporal lobe of 6M-old APP/PS1 mice (C) MiR-195 doesn''t reverse the high expression of AT8 in the brain of 6M-old APP/PS1 mice. * p < 0.05 vs. WT (D) MiR-195 levels in the hippocampus and cortex of APP/PS1 mice after intracerebral injection of Lv-pre -miR-195 2M. * p < 0.05 vs. WT. n = 6.
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- FIGURE 7 The effect of miR-195 on the expression of APP, BACE-1, AT8 protein in the hippocampi of APP/PS1 mice after Lv-pre -miR-195 injection for 3M (A) MiR-195 down-regulated the expression of APP protein in the hippocampus and temporal lobe of APP/PS1 mice. * p < 0.05 vs. WT. # p < 0.05 vs. Lv-NC (B) There was no significant change in BACE-1 protein in hippocampus and temporal lobe of 7M-old APP/PS1 mice (C) MiR-195 reverses the high expression of AT8 in the temporal lobe of 7M-old APP/PS1 mice, but not in the hippocampus. * p < 0.05 vs. WT (D) MiR-195 levels in the hippocampus and cortex of APP/PS1 mice after brain injection of Lv-pre -miR-195 for 3M. * p < 0.05 vs. WT. # p < 0.05 vs. Lv-NC. n = 6.
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- Fig. 2 Sevoflurane increased extracellular amounts of tau and p-tau in WT neuron culture medium. a Experimental design. b Western blot of p-tau in neuron lysates. c Quantification of the Western blot in b . d ELISA of extracellular tau outside of neurons in the neuron culture medium with and without lithium treatment. e Nanobeam-sensor spectrum data representing extracellular p-tau outside of neurons in the neuron culture medium. f Quantification of the nanobeam-sensor measurement of extracellular p-tau outside of neurons in the neuron culture medium with and without lithium treatment. g Quantification of the nanobeam-sensor measurement of extracellular p-tau outside of neurons in the neuron culture medium with and without GW4869 treatment. h LDH assay to determine extracellular LDH amounts outside of neurons in the neuron culture medium. i Effects of sevoflurane on p-tau amount in brain ISF of both WT and AD Tg mice. N = 3 or 5 biologically independent samples (tau and p-tau measurement) as demonstrated in the panel of the figure, 6 biologically independent samples (LDH assay) and 9 mice (ISF p-tau amount) in each group. Two-way ANOVA and post-hoc analysis with Bonferroni were used to analyze the data presented in Fig. 2c, d, f, g, i. The P values of the two-way ANOVA refer to the interaction of group (control condition versus sevoflurane), treatment (vehicle versus lithium or GW4869) or mice (WT versus AD Tg mice). The P values of post-hoc analysis with Bonferroni refer to
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- Fig. 5 Sevoflurane-conditioned neuron culture medium caused the appearance of tau and p-tau in tau KO microglia. a Experimental design. b Immunohistochemistry showing the appearance of p-tau in a group of tau KO microglia following the treatment of sevoflurane-conditioned neuron culture medium. c Immunohistochemistry showing the appearance of p-tau in a single tau KO microglia following the treatment of sevoflurane-conditioned neuron culture medium. d Nanobeam-sensor spectrum data representing tau in the lysates of tau KO microglia following the treatment of sevoflurane-conditioned neuron culture medium with and without lithium. e Quantification of nanobeam-sensor measurement of tau. f Nanobeam-sensor spectrum data representing p-tau in the lysates of tau KO microglia following the treatment of sevoflurane-conditioned neuron culture medium with and without lithium. g Quantification of nanobeam-sensor measurement of p-tau. h Nanobeam-sensor measurement of tau in the lysates of tau KO microglia following the treatment of sevoflurane-conditioned neuron culture medium with and without GW4869. i Nanobeam-sensor measurement of p-tau in the lysates of tau KO microglia following the treatment of sevoflurane-conditioned neuron culture medium with and without GW4869. N = 3 biologically independent samples in each group. Two-way ANOVA and post-hoc analysis with Bonferroni were used to analyze the data presented in Fig. 5e, g, h, i. The P values of two-way ANOVA refer to the interaction
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- Figure 2 Phosphorylation-independent detection of endogenous mouse tau with the new antibodies. (a) Western blot analysis to confirm phosphorylation of tau in hypothermic animals. To induce hyperphosphorylation of tau in the mouse brain, animals were anesthetized and kept at room temperature to induce anesthesia-induced hypothermia. The samples were subjected to Western blotting with RTM38, AT8, and tau1 antibodies. (b) Quantification of the immunoreactive bands in (a). The optical density of the total immunoreactive bands in each blot was measured in samples from three animals in each condition, averaged, and normalized to the mean of the control samples. The mean values were compared between the control (Cont) and hypothermic (hypo) conditions using Student's t test. * p < .0001. There was no significant difference for RTM38. (c) Immunofluorescence staining of tau in the hippocampus of control and hypothermic animals. Brains of animals fixed via transcardiac perfusion were immunostained with tau-1 (green), RTM38 (red), or anti-tauN (blue) antibodies. Images were taken with a fixed setting for each antibody. Note that the immunoreactivity is reduced for tau-1 after hypothermia. Scale bar, 100 mum
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- Figure 4. Microglia drive tau pathogenesis and mediate apoE's effect on tau pathogenesis. (A) Representative images of the four major ptau staining patterns in 9.5-mo-old TE4 and TEKO mice. Scale bar = 500 mum for all images. (B) Distribution of the four ptau staining patterns in 9.5-mo-old TE4 and TEKO mice treated with control (Ctl) or PLX3397-supplemented (PLX) chow (TE4-Ctl: n = 21; TE4-PLX: n = 17; TEKO-Ctl: n = 19; TEKO-PLX: n = 18). Fisher's exact test, two-sided (all groups: P = 2.2 x 10 4 ; TE4-Ctl vs. TE4-PLX: P = 4.1 x 10 4 ; TE4-Ctl vs. TEKO-Ctl: P = 4.1 x 10 4 ). (C) Quantification of ptau (AT8)-covered area in the hippocampus of these mice. (D) Representative images of early-type1 and late-type1 ptau staining patterns within the type1 category (same image used for type1 and type1-early in A and D, respectively). Scale bar = 500 mum for both images. (E) Distribution of early-type1 and late-type1 ptau patterns in TE4 and TEKO mice harboring the type1 ptau staining pattern (TE4-Ctl: n = 6; TE4-PLX: n = 15; TEKO-Ctl: n = 11; TEKO-PLX: n = 11). Fisher's exact test, two-sided (all groups: P = 0.0097; TEKO-Ctl vs. TEKO-PLX: P = 0.0089). Data are expressed as means +- SEM. One-way ANOVA with Tukey's post hoc test (two-sided). **, P < 0.01; ***, P < 0.001. The AT8 staining was performed once.
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- 2 FIGURE HAE-4 significantly reduced Abeta-driven tau seeding and spreading in 8-month-old AD-tau injected 5XE4 mice. (A) Representative images of AT8 + NP-tau in 5XE4 mice. Scale bars, 1 mm. (B) Quantification of the area covered by AT8 + staining in the ipsi- and contralateral hippocampi and cortices of AD-tau-injected 5XE4 mice. (C) Confocal images of AT8 + NP-tau (green) around X34 + plaques (blue) in the ipsilateral subiculum of the hippocampus. Scale bars, 20 mum. (D) Quantification of percentage AT8 + volume within 15 mum of plaques in the ipsilateral subiculum of the hippocampus. Data are presented as mean +- SEM. *, p
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- FIGURE 1 Immunohistochemical analysis of Abeta and pTau. Representative photomicrographs and quantification of 6E10-positive Abeta plaques (A) and AT8-positive pTau lesions (B) in the middle frontal gyrus of non-demented subjects and AD patients. Arrows in (A) point to dense-core plaques. No signal was observed in the IgG1 isotype controls. Levels of Abeta and pTau immunoreactivity were higher in AD vs. non-AD subjects ( * P < 0.05, Mann-Whitney U tests, two-tailed). Results are presented as the median and interquartile range of n = 7 subjects/group. Scale bars: 50 mum.
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- Figure 10. Mini-GAGR reduces p-tau and Abeta peptide and improves learning and possibly memory retention in 12-month-old female 3xTg-AD mouse brains. A and B , the cytosols of combined hippocampal and cortical tissues from 3xTg-AD mice treated with either vehicle or 100 nmol of mini-GAGR for 20 days were used for immunoblotting for p-tau and tau. The band densities of tau and p-tau were quantified by ImageJ to obtain average density +- S.E. ( error bars ) for bar graphs: tau (50 kDa): control versus mini-GAGR ( C ); p-tau (64 kDa): control versus mini-GAGR ( n = 5 animals; **, p < 0.01) ( D ). E and F , the hippocampal sections of 3xTg-AD mice treated with either vehicle ( E ) or 100 n m mini-GAGR ( F ) were stained with anti-Abeta antibody (6E10) and HRP-tagged secondary antibody ( scale bar , 250 mum). G , bar graphs show the average number of Abeta-positive hippocampal CA1-CA3 and DG regions of 3xTg-AD mice treated with either vehicle or 100 n m mini-GAGR ( n = 6 animals (15 sections)/treatment; **, p < 0.01). G-J , 3xTg-AD mice treated with either vehicle or 100 n m mini-GAGR for 14 days were subjected to the open field paradigm to measure basal locomotor function. There was no difference in vehicle-treated versus mini-GAGR-treated mice regarding mean speed (cm/s) ( H ) and total distance (cm) ( I ). J and K , to determine the effect of mini-GAGR on learning and memory in 3xTg-AD mice ( n = 7 mice/treatment group), the Barnes maze paradigm was p
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- Figure 2 Lack of PBS-soluble phosphorylated HMW tau species is associated with low tau uptake in primary neurons. ( a , top) Uptake of human tau from brain extracts from rTg4510 and rTg21221 mice by primary neurons (PBS-3,000 g , 500 ng ml -1 human tau). Neurons were immunostained with human tau-specific antibody (green) and total (human and mouse) tau antibody (red). ( a , bottom) Tau uptake assay in HEK-tau-biosensor cells. Brain extracts (10 mug protein) were applied to the cells (lipofectamie (-)). ( n =4) Unpaired t -test. Scale bar, 50 mum. ( b ) Human tau levels in brain extracts (ELISA). ( c ) Immunoblot analysis of PBS-soluble extracts with total tau antibody (DA9). Up-shifted bands in rTg4510 brain suggest phosphorylation of tau (arrow). ( d ) Brain extracts were immunoblotted with phospho-tau specific antibodies recognizing different epitopes. Representative immunoblot and quantification of phospho-tau levels at each epitope. ( n =3-4) Unpaired t -test. ( e , f ) SEC analysis of PBS-soluble tau. ( e ) Representative graph of human tau levels (ELISA) in SEC-separated samples ( f ) Mean human tau levels of HMW (Frc. 2-4) and LMW (Frc. 13-16) SEC fractions. ( n =3-6) Unpaired t -test. ( g ) Immunoblot analysis (SDS-PAGE) of SEC-separated fractions from brain extracts (total tau, DAKO). Quantification of band density is also shown (right graphs) ( n =4). Unpaired t -test. ( h ) Dot blot analysis of PBS-soluble brain extracts with tau oligomer-specific antibody (T22), h
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- 2 Hippocampal localization of LPS-induced tau-P and inflammatory responses. Immunoperoxidase staining for AT8-phosphorylated tau (top), ionized calcium binding adaptor molecule 1 (Iba1; middle) and cyclo-oxygenase 2 (COX-2) immunoreactivities in saline-injected controls (Sal) and at 1-3 h after systemic LPS challenge. LPS increases tau-P principally in hilar neurons of the dentate gyrus and CA3 pyramidal cells. Less prominent responses are seen in a few cells in deep aspects of the dentate granule cell layer (gr). Among inflammatory markers, a progressive retraction and thickening of the processes of Iba-1-positive microglial cells is apparent over 1-3 h after LPS treatment. COX-2 cellular labeling is more prominent at 2-3 h post injection, at which time enzyme expression is induced in vascular-associated cells. Scale bars - 100 mum (top); 50 mum (middle and bottom).
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