10274-1-AP
antibody from Proteintech Group
Targeting: MAPT
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 10274-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10274-1-AP, RRID:AB_2139718
- Product name
- TAU antibody
- Antibody type
- Polyclonal
- Description
- TAU antibody (Cat. #10274-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Beneficial Effects of Echinacoside on Cognitive Impairment and Diabetes in Type 2 Diabetic db/db Mice.
The mechanism of chemokine receptor ACKR2 in cognitive impairment in young rats with traumatic brain injury.
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway.
Overexpression of fibroblast growth factor 13 ameliorates amyloid-β-induced neuronal damage.
Amelioration of central neurodegeneration by docosahexaenoic acid in trigeminal neuralgia rats through the regulation of central neuroinflammation.
The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model.
miRNA-137-5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin-specific peptidase 30.
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors.
Low-Intensity Focused Ultrasound Alleviates Chronic Neuropathic Pain-Induced Allodynia by Inhibiting Neuroplasticity in the Anterior Cingulate Cortex.
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.
Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis.
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.
ErbB4 mediates amyloid β-induced neurotoxicity through JNK/tau pathway activation: Implications for Alzheimer's disease.
Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force.
The effects of antimony on Alzheimer's disease-like pathological changes in mice brain.
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.
Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines.
Effects of the histone acetylase inhibitor C646 on growth and differentiation of adipose-derived stem cells.
Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid.
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.
Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.
TDZD-8 alleviates delayed neurological sequelae following acute carbon monoxide poisoning involving tau protein phosphorylation.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.
Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism.
Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth.
Receptor-Mediated Field Effect Transistor Biosensor for Real-Time Monitoring of Glutamate Release from Primary Hippocampal Neurons.
The protective mechanism underlying phenylethanoid glycosides (PHG) actions on synaptic plasticity in rat Alzheimer's disease model induced by beta amyloid 1-42.
Dental pulp stem cells promote regeneration of damaged neuron cells on the cellular model of Alzheimer's disease.
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance.
Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice.
Wang Z, Bi M, Zhe X, Wang X, Dai B, Han X, Ren B, Liang H, Liu D
Cell death discovery 2024 Feb 22;10(1):95
Cell death discovery 2024 Feb 22;10(1):95
Beneficial Effects of Echinacoside on Cognitive Impairment and Diabetes in Type 2 Diabetic db/db Mice.
Qin F, Yan Y, Yang N, Hao Y
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2024 Aug;132(8):420-430
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2024 Aug;132(8):420-430
The mechanism of chemokine receptor ACKR2 in cognitive impairment in young rats with traumatic brain injury.
Quan L, Zhao Y, Ouyang C, Ying D, Xiong Z, Li X, Liao Z, Luo J, Liu H
American journal of translational research 2023;15(3):1654-1666
American journal of translational research 2023;15(3):1654-1666
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Meng Q, Chao Y, Zhang S, Ding X, Feng H, Zhang C, Liu B, Zhu W, Li Y, Zhang Q, Tong H, Wu L, Bian H
Molecular brain 2023 Nov 20;16(1):80
Molecular brain 2023 Nov 20;16(1):80
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway.
Wang G, Shen X, Song X, Wang N, Wo X, Gao Y
Neurotoxicology 2023 Mar;95:12-22
Neurotoxicology 2023 Mar;95:12-22
Overexpression of fibroblast growth factor 13 ameliorates amyloid-β-induced neuronal damage.
Li RM, Xiao L, Zhang T, Ren D, Zhu H
Neural regeneration research 2023 Jun;18(6):1347-1353
Neural regeneration research 2023 Jun;18(6):1347-1353
Amelioration of central neurodegeneration by docosahexaenoic acid in trigeminal neuralgia rats through the regulation of central neuroinflammation.
Mu G, Ren C, Zhang Y, Lu B, Feng J, Wu D, Xu X, Ou C
International immunopharmacology 2023 Jan;114:109544
International immunopharmacology 2023 Jan;114:109544
The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model.
Li Y, Xu J, Guo X, Li Z, Cao L, Liu S, Guo Y, Wang G, Luo Y, Zhang Z, Wei X, Zhao Y, Liu T, Wang X, Xia H, Kuang M, Guo Q, Li J, Chen L, Wang Y, Li Q, Wang F, Liu Q, You F
Genome biology 2023 Feb 1;24(1):20
Genome biology 2023 Feb 1;24(1):20
miRNA-137-5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin-specific peptidase 30.
Jiang Y, Bian W, Chen J, Cao X, Dong C, Xiao Y, Xu B, Sun X
Animal models and experimental medicine 2023 Dec;6(6):526-536
Animal models and experimental medicine 2023 Dec;6(6):526-536
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors.
Zhang T, Wang WL, Liu TJ, Lu S, Bian YC, Xiao R, Zhang CL
Biological & pharmaceutical bulletin 2022;45(11):1616-1626
Biological & pharmaceutical bulletin 2022;45(11):1616-1626
Low-Intensity Focused Ultrasound Alleviates Chronic Neuropathic Pain-Induced Allodynia by Inhibiting Neuroplasticity in the Anterior Cingulate Cortex.
Wang B, Chen MX, Chen SC, Feng XJ, Liao YH, Zhao YX, Tie JS, Liu Y, Ao LJ
Neural plasticity 2022;2022:6472475
Neural plasticity 2022;2022:6472475
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.
Luo K, Wang Y, Chen WS, Feng X, Liao Y, Chen S, Liu Y, Liao C, Chen M, Ao L
Neural plasticity 2022;2022:5241449
Neural plasticity 2022;2022:5241449
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.
Pan L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G, Zhang Z
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.
Zeng L, Jiang H, Ashraf GM, Liu J, Wang L, Zhao K, Liu M, Li Z, Liu R
Molecular therapy. Nucleic acids 2022 Mar 8;27:256-275
Molecular therapy. Nucleic acids 2022 Mar 8;27:256-275
Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.
Ali TFS, Ciftci HI, Radwan MO, Roshdy E, Shawky AM, Abourehab MAS, Tateishi H, Otsuka M, Fujita M
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Han QJ, Han G, Peng J, Tang Z
Free radical biology & medicine 2022 Feb 1;179:416-417
Free radical biology & medicine 2022 Feb 1;179:416-417
Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis.
Chong S, Chen G, Dang Z, Niu F, Zhang L, Ma H, Zhao Y
Bioengineered 2022 Apr;13(4):8747-8758
Bioengineered 2022 Apr;13(4):8747-8758
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.
Yang XB, Zu HB, Zhao YF, Yao K
Frontiers in aging neuroscience 2021;13:766410
Frontiers in aging neuroscience 2021;13:766410
ErbB4 mediates amyloid β-induced neurotoxicity through JNK/tau pathway activation: Implications for Alzheimer's disease.
Zhang H, Zhang L, Zhou D, Li H, Xu Y
The Journal of comparative neurology 2021 Oct;529(15):3497-3512
The Journal of comparative neurology 2021 Oct;529(15):3497-3512
Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force.
Wang Y, Zhou J, Tang C, Yu J, Zhu W, Guo J, Wang Y
Journal of cellular physiology 2021 Mar;236(3):2156-2168
Journal of cellular physiology 2021 Mar;236(3):2156-2168
The effects of antimony on Alzheimer's disease-like pathological changes in mice brain.
Xu S, Yang Z, Zhi Y, Yu S, Zhang T, Jiang J, Tang J, He H, Lu M, Wang X, Wu Q, Zhao X
The Science of the total environment 2021 Mar 15;760:143235
The Science of the total environment 2021 Mar 15;760:143235
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.
Perez Garcia G, De Gasperi R, Gama Sosa MA, Perez GM, Otero-Pagan A, Pryor D, Abutarboush R, Kawoos U, Hof PR, Dickstein DL, Cook DG, Gandy S, Ahlers ST, Elder GA
Acta neuropathologica communications 2021 Mar 1;9(1):33
Acta neuropathologica communications 2021 Mar 1;9(1):33
Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
Nie F, Zhang Q, Ma J, Wang P, Gu R, Han J, Zhang R
Journal of neurochemistry 2021 Jun;157(6):1745-1758
Journal of neurochemistry 2021 Jun;157(6):1745-1758
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z
Free radical biology & medicine 2021 Jan;162:181-190
Free radical biology & medicine 2021 Jan;162:181-190
NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines.
Wang X, Yin Z, Cao P, Zheng S, Chen Y, Yu M, Liao C, Zhang Z, Duan Y, Han J, Zhang S, Yang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110964
Effects of the histone acetylase inhibitor C646 on growth and differentiation of adipose-derived stem cells.
Wang Z, Wang X, Bi M, Hu X, Wang Q, Liang H, Liu D
Cell cycle (Georgetown, Tex.) 2021 Feb;20(4):392-405
Cell cycle (Georgetown, Tex.) 2021 Feb;20(4):392-405
Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid.
Pan Y, Zhang Y, Liu N, Lu W, Yang J, Li Y, Liu Z, Wei Y, Lou Y, Kong J
ACS chemical neuroscience 2021 Apr 21;12(8):1343-1350
ACS chemical neuroscience 2021 Apr 21;12(8):1343-1350
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Yin Z, Wang X, Zheng S, Cao P, Chen Y, Yu M, Liao C, Zhang Z, Han J, Duan Y, Yang X, Zhang S
Frontiers in aging neuroscience 2020;12:582455
Frontiers in aging neuroscience 2020;12:582455
Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.
Yin Z, Hua L, Chen L, Hu D, Li J, An Z, Tian T, Ning H, Ge Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104911
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104911
Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.
Tao Q, Wang X, Liu L, Ji Y, Luo Q, Du J, Yu L, Shen J, Chu D
Acta tropica 2020 Oct;210:105560
Acta tropica 2020 Oct;210:105560
TDZD-8 alleviates delayed neurological sequelae following acute carbon monoxide poisoning involving tau protein phosphorylation.
Su C, Zhao N, Zou J, Yan X
Inhalation toxicology 2020 Feb;32(2):79-85
Inhalation toxicology 2020 Feb;32(2):79-85
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.
Fang B, Zhao Q, Ling W, Zhang Y, Ou M
American journal of translational research 2019;11(12):7591-7603
American journal of translational research 2019;11(12):7591-7603
Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism.
Chen X, Li H, Yang Q, Lan X, Wang J, Cao Z, Shi X, Li J, Kan M, Qu X, Li N
Molecular biology reports 2019 Oct;46(5):5323-5332
Molecular biology reports 2019 Oct;46(5):5323-5332
Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth.
Wang Y, Zhang X, Tian J, Shan J, Hu Y, Zhai Y, Guo J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6311-6326
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6311-6326
Receptor-Mediated Field Effect Transistor Biosensor for Real-Time Monitoring of Glutamate Release from Primary Hippocampal Neurons.
Li YT, Jin X, Tang L, Lv WL, Xiao MM, Zhang ZY, Gao C, Zhang GJ
Analytical chemistry 2019 Jul 2;91(13):8229-8236
Analytical chemistry 2019 Jul 2;91(13):8229-8236
The protective mechanism underlying phenylethanoid glycosides (PHG) actions on synaptic plasticity in rat Alzheimer's disease model induced by beta amyloid 1-42.
Jia JX, Yan XS, Song W, Fang X, Cai ZP, Huo DS, Wang H, Yang ZJ
Journal of toxicology and environmental health. Part A 2018;81(21):1098-1107
Journal of toxicology and environmental health. Part A 2018;81(21):1098-1107
Dental pulp stem cells promote regeneration of damaged neuron cells on the cellular model of Alzheimer's disease.
Wang F, Jia Y, Liu J, Zhai J, Cao N, Yue W, He H, Pei X
Cell biology international 2017 Jun;41(6):639-650
Cell biology international 2017 Jun;41(6):639-650
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance.
Yang JY, Ha SA, Yang YS, Kim JW
BMC cancer 2010 Jul 22;10:388
BMC cancer 2010 Jul 22;10:388
Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice.
Rodríguez-Navarro JA, Gómez A, Rodal I, Perucho J, Martinez A, Furió V, Ampuero I, Casarejos MJ, Solano RM, de Yébenes JG, Mena MA
Human molecular genetics 2008 Oct 15;17(20):3128-43
Human molecular genetics 2008 Oct 15;17(20):3128-43
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HT-1080 cells were subjected to SDS PAGE followed by western blot with 10274-1-AP(TAU antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 10274-1-AP(TAU antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TAU antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TAU. This antibody recognizes human, mouse, rat antigen. The TAU antibody has been validated for the following applications: ELISA, WB, IHC analysis.