10274-1-AP
antibody from Proteintech Group
Targeting: MAPT
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
Antibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 10274-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10274-1-AP, RRID:AB_2139718
- Product name
- TAU antibody
- Antibody type
- Polyclonal
- Description
- TAU antibody (Cat. #10274-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Relationship Between Gut Microbiota-Related Hippocampal Tryptophan Metabolite and Alzheimer's Disease-Like Neurobehavioral Changes Induced by Chronic Inorganic Arsenic Exposure in Rats.
A small-molecule stabilizer of the calpastatin-calpain-2 complex restores mitochondrial function and mitigates neurodegeneration.
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Procoagulant Extracellular Vesicles Increase Neuronal Tau expression, Metabolism and Processing Through Tissue Factor and Protease Activated Receptor 2.
Neuroprotective Effects of Desert Milk Exosomes in LPS-Induced Cognitive Decline: Role of Microglial M2 Polarization and AMPK Signaling.
ISX9 activates the Wnt/β-catenin signaling pathway and exerts neuroprotective effects in Alzheimer's disease.
Self-Assembled Rg3/Naringenin Nanoparticles for Targeted Brain Delivery: A Promising Therapeutic Approach for Early Alzheimer's Disease.
Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.
E3 ligase Praja1 mediates ubiquitination and degradation of microtubule-associated protein tau.
Olfactory Dysfunction Exacerbates Hippocampal Aβ Accumulation, Tau Phosphorylation and Memory Deficits in Mice.
Engineered Alzheimer Organoids Validate the Link Between Intracellular and Soluble p-Tau Biomarkers and Highlight the Contribution of Astrocytic Tau.
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.
Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons.
Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer's disease.
Multi-Omics Integration Reveals Electroacupuncture Ameliorates Cognitive Impairment in Alzheimer's Disease via Gut-Brain Axis.
Myricetin Suppresses Inflammatory Th17 Polarization to Mitigate Alzheimer's Disease Pathogenesis.
Dual Mechanisms of Cognitive Function and Pathological Improvements by the Selective S1PR1/5 Modulator Siponimod in 3xTg-AD Mice.
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease.
Glucose starvation induces tau phosphorylation leading to cellular stress response in fission yeast.
LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in rats.
Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss.
Uncovering the epigenetic regulatory clues of PRRT1 in Alzheimer's disease: a strategy integrating multi-omics analysis with explainable machine learning.
Reversal of neuronal tau pathology via adiponectin receptor activation.
Comparative Analysis of Egg Yolk Phospholipid Unsaturation and Its Impact on Neural Health in Alzheimer Disease Mice.
From Microbiota to Metabolomics: How Corylus heterophylla Fisch. Male Flower Extract Shields Mice from Cognitive Decline.
Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation.
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Systems genetics identifies methionine as a high risk factor for Alzheimer's disease.
Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice.
Tetradecyl 2,3-Dihydroxybenzoate Improves Cognitive Function in AD Mice by Modulating Autophagy and Inflammation Through IPA and Hsc70 Targeting.
Bifidobacterium lactis-Derived Vesicles Attenuate Hippocampal Neuroinflammation by Targeting IL-33 to Regulate FoxO6/P53 Signaling.
Neuropathological Heterogeneity of Dementia Due to Combined Pathology in Aged Patients: Clinicopathological Findings in the Vallecas Alzheimer's Reina Sofía Cohort.
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Beneficial Effects of Echinacoside on Cognitive Impairment and Diabetes in Type 2 Diabetic db/db Mice.
The mechanism of chemokine receptor ACKR2 in cognitive impairment in young rats with traumatic brain injury.
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway.
Overexpression of fibroblast growth factor 13 ameliorates amyloid-β-induced neuronal damage.
Amelioration of central neurodegeneration by docosahexaenoic acid in trigeminal neuralgia rats through the regulation of central neuroinflammation.
The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model.
miRNA-137-5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin-specific peptidase 30.
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors.
Low-Intensity Focused Ultrasound Alleviates Chronic Neuropathic Pain-Induced Allodynia by Inhibiting Neuroplasticity in the Anterior Cingulate Cortex.
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.
Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis.
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.
ErbB4 mediates amyloid β-induced neurotoxicity through JNK/tau pathway activation: Implications for Alzheimer's disease.
Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force.
The effects of antimony on Alzheimer's disease-like pathological changes in mice brain.
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.
Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines.
Effects of the histone acetylase inhibitor C646 on growth and differentiation of adipose-derived stem cells.
Vitamin D Attenuates Alzheimer-like Pathology Induced by Okadaic Acid.
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.
Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.
TDZD-8 alleviates delayed neurological sequelae following acute carbon monoxide poisoning involving tau protein phosphorylation.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.
Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism.
Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth.
Receptor-Mediated Field Effect Transistor Biosensor for Real-Time Monitoring of Glutamate Release from Primary Hippocampal Neurons.
The protective mechanism underlying phenylethanoid glycosides (PHG) actions on synaptic plasticity in rat Alzheimer's disease model induced by beta amyloid 1-42.
Dental pulp stem cells promote regeneration of damaged neuron cells on the cellular model of Alzheimer's disease.
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance.
Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice.
Chen K, Zhao Q, Li S, Wang J, Feng C, Wang L, Yan X, Li B, Zhao Q, Qiu Y
Biological trace element research 2026 Mar;204(3):1781-1795
Biological trace element research 2026 Mar;204(3):1781-1795
A small-molecule stabilizer of the calpastatin-calpain-2 complex restores mitochondrial function and mitigates neurodegeneration.
Hu D, Sun X, Shang Y, Lundberg K, Adams DJ, Qi X
Science advances 2026 Mar 27;12(13):eaeb1174
Science advances 2026 Mar 27;12(13):eaeb1174
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Wang J, Chen P, Li Y, Wang R, Ding W, Yu R, Qin Q, Wu R, Wei W, Shi J, Yuan H, Zhuang C, Sun Y
Free radical biology & medicine 2026 Jun;249:165-179
Free radical biology & medicine 2026 Jun;249:165-179
Procoagulant Extracellular Vesicles Increase Neuronal Tau expression, Metabolism and Processing Through Tissue Factor and Protease Activated Receptor 2.
Featherby SJ, Faulkner EC, Gordon A, Ettelaie C
Cellular and molecular neurobiology 2026 Jan 6;46(1):21
Cellular and molecular neurobiology 2026 Jan 6;46(1):21
Neuroprotective Effects of Desert Milk Exosomes in LPS-Induced Cognitive Decline: Role of Microglial M2 Polarization and AMPK Signaling.
Li Y, Lu W, Qian W, Liao X, Wang P, Wang Y, Jiao W, Wang M, Zhao J, Yang J, Gao H, Li H
Nutrients 2026 Jan 19;18(2)
Nutrients 2026 Jan 19;18(2)
ISX9 activates the Wnt/β-catenin signaling pathway and exerts neuroprotective effects in Alzheimer's disease.
Xiao J, Liu Y, Peng M, Ma J, Lei S, Chen Y, Liu S, Zhao X, Lu D, Sun Q
Alzheimer's research & therapy 2026 Feb 5;18(1)
Alzheimer's research & therapy 2026 Feb 5;18(1)
Self-Assembled Rg3/Naringenin Nanoparticles for Targeted Brain Delivery: A Promising Therapeutic Approach for Early Alzheimer's Disease.
Lou X, Ni Z, Cui S, He Z, Zong Y, Chen W, Geng J, Zhou J, Li Z, Zhao Y, Teng H
Pharmaceuticals (Basel, Switzerland) 2026 Feb 26;19(3)
Pharmaceuticals (Basel, Switzerland) 2026 Feb 26;19(3)
Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.
Liu Z, Shen Y, Luo AD, Ao WL, Guan SQ, Lei F, Xu ZC, Yu CY, Xu P, Huang H
Neurochemical research 2026 Feb 17;51(2):74
Neurochemical research 2026 Feb 17;51(2):74
E3 ligase Praja1 mediates ubiquitination and degradation of microtubule-associated protein tau.
Aoki S, Onodera W, Takashima A, Kawasaki K, Imadegawa K, Kurahashi H, Oishi M, Asahi T, Soeda Y
The FEBS journal 2026 Apr;293(8):2212-2224
The FEBS journal 2026 Apr;293(8):2212-2224
Olfactory Dysfunction Exacerbates Hippocampal Aβ Accumulation, Tau Phosphorylation and Memory Deficits in Mice.
Du M, Ma S, Bai L, Mou X, Gao Y, Zhang J, Chen Y
Neurochemical research 2026 Apr 3;51(2)
Neurochemical research 2026 Apr 3;51(2)
Engineered Alzheimer Organoids Validate the Link Between Intracellular and Soluble p-Tau Biomarkers and Highlight the Contribution of Astrocytic Tau.
Zhang R, Dong X, Pei G, Huang S
Neuroscience bulletin 2026 Apr 11;
Neuroscience bulletin 2026 Apr 11;
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.
Konishi S, Enkhbayar K, Liu S, Miyashita N, Kobayashi Y, Hutchison V, Sai A, Agarwal P, Witonsky J, Jackson ND, Seibold MA, Chen J, Tata A, Tata PR
The Journal of clinical investigation 2026 Apr 1;136(7)
The Journal of clinical investigation 2026 Apr 1;136(7)
Pathogenic mechanisms of amyotrophic lateral sclerosis-linked VAPB P56S mutation in the degeneration of corticospinal motor neurons.
Yang X, Zheng J, Wang X, Cai H, Yu J
Ageing and neurodegenerative diseases 2025;5(3)
Ageing and neurodegenerative diseases 2025;5(3)
Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer's disease.
Meden A, Žnidaršič N, Knez D, Wang Y, Xu Z, Yang H, Zhang W, Pišlar A, Perdih A, Brezar SK, Grgurevič N, Pajk S, Sun H, Gobec S
Acta pharmaceutica Sinica. B 2025 Sep;15(9):4807-4828
Acta pharmaceutica Sinica. B 2025 Sep;15(9):4807-4828
Multi-Omics Integration Reveals Electroacupuncture Ameliorates Cognitive Impairment in Alzheimer's Disease via Gut-Brain Axis.
Zhang S, Liu X, Xu S, Li W, Song J, Tian Q, Du Y
Biomolecules 2025 Oct 22;15(11)
Biomolecules 2025 Oct 22;15(11)
Myricetin Suppresses Inflammatory Th17 Polarization to Mitigate Alzheimer's Disease Pathogenesis.
Li Y, Sun A, Han J, Hong R, Cao C, Zhou A, Fan Z, Zhang L, Qu X
CNS neuroscience & therapeutics 2025 Nov;31(11):e70644
CNS neuroscience & therapeutics 2025 Nov;31(11):e70644
Dual Mechanisms of Cognitive Function and Pathological Improvements by the Selective S1PR1/5 Modulator Siponimod in 3xTg-AD Mice.
Tang C, Ding Y, Yang S, Lei X, Zhang M, Xu B, He D
Molecular neurobiology 2025 Nov 22;63(1):133
Molecular neurobiology 2025 Nov 22;63(1):133
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
Li ZD, Kang S, Li H, Yu P, Xie R, Li C, Jing Q, Gong Z, Li L, Li Z, Geng M, Zhang Z, Li Y, Chang YZ
Redox biology 2025 May;82:103611
Redox biology 2025 May;82:103611
The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease.
Shen H, Xie Y, Wang Y, Xie Y, Wang Y, Su Z, Zhao L, Yao S, Cao X, Liang J, Long J, Zhong R, Tang J, Wang S, Zhang L, Wang X, Stork B, Cui L, Wu W
Autophagy 2025 May;21(5):1096-1115
Autophagy 2025 May;21(5):1096-1115
Glucose starvation induces tau phosphorylation leading to cellular stress response in fission yeast.
Yılmazer M, Şengelen A, Aksüt Y, Palabıyık B, Önay-Uçar E, Karaer Uzuner S
Archives of microbiology 2025 May 19;207(7):148
Archives of microbiology 2025 May 19;207(7):148
LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in rats.
Ning Y, Zhang Y, Jiang T, Feng J, Zhan J, Ou C, Wang L
Neuroscience research 2025 Mar;212:84-96
Neuroscience research 2025 Mar;212:84-96
Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss.
Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei ZN, Hu W, Sun G, Huang G, He C, Fretz J, Hettinghouse A, Liu R, Cai X, Zhang M, Chen Y, Jiang N, He M, Wiznia DH, Xu H, Chen ZS, Chen L, Tang K, Zhou H, Liu CJ
Cell research 2025 Jan;35(1):23-44
Cell research 2025 Jan;35(1):23-44
Uncovering the epigenetic regulatory clues of PRRT1 in Alzheimer's disease: a strategy integrating multi-omics analysis with explainable machine learning.
Wang F, Liang Y, Wang QW
Alzheimer's research & therapy 2025 Jan 7;17(1):12
Alzheimer's research & therapy 2025 Jan 7;17(1):12
Reversal of neuronal tau pathology via adiponectin receptor activation.
McGregor ER, Lasky DJ, Rippentrop OJ, Clark JP, Wright S, Jones MV, Anderson RM
Communications biology 2025 Jan 4;8(1):8
Communications biology 2025 Jan 4;8(1):8
Comparative Analysis of Egg Yolk Phospholipid Unsaturation and Its Impact on Neural Health in Alzheimer Disease Mice.
Sun Y, Wu Y, Fang B, Li J, Liu Y, Gao H, Zhang M
Foods (Basel, Switzerland) 2025 Feb 26;14(5)
Foods (Basel, Switzerland) 2025 Feb 26;14(5)
From Microbiota to Metabolomics: How Corylus heterophylla Fisch. Male Flower Extract Shields Mice from Cognitive Decline.
Lu W, Li Y, Liao X, Hu H, Zhang B, Liang L, Gao H
Nutrients 2025 Dec 18;17(24)
Nutrients 2025 Dec 18;17(24)
Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation.
Chu J, Song J, Fan Z, Zhang R, Wang Q, Yi K, Gong Q, Liu B
Pharmaceuticals (Basel, Switzerland) 2025 Apr 22;18(5)
Pharmaceuticals (Basel, Switzerland) 2025 Apr 22;18(5)
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Lu J, Su P, Zhao F, Yu K, Yang X, Lv H, Wang D, Zhang J
Current research in toxicology 2024;7:100193
Current research in toxicology 2024;7:100193
Systems genetics identifies methionine as a high risk factor for Alzheimer's disease.
Wang C, Hei Y, Liu Y, Bajpai AK, Li Y, Guan Y, Xu F, Yao C
Frontiers in neuroscience 2024;18:1381889
Frontiers in neuroscience 2024;18:1381889
Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice.
Zou Y, Wang C, Li H, Zhong M, Lin J, Hu Y, Chen Z, Gan CL
Frontiers in pharmacology 2024;15:1500105
Frontiers in pharmacology 2024;15:1500105
Tetradecyl 2,3-Dihydroxybenzoate Improves Cognitive Function in AD Mice by Modulating Autophagy and Inflammation Through IPA and Hsc70 Targeting.
Fasina OB, Li L, Chen D, Yi M, Xiang L, Qi J
International journal of molecular sciences 2024 Oct 31;25(21)
International journal of molecular sciences 2024 Oct 31;25(21)
Bifidobacterium lactis-Derived Vesicles Attenuate Hippocampal Neuroinflammation by Targeting IL-33 to Regulate FoxO6/P53 Signaling.
Du X, Zhang M, Wang R, Zeng Z, Zhao W, Fang B, Lan H, Hung W, Gao H
Nutrients 2024 Oct 22;16(21)
Nutrients 2024 Oct 22;16(21)
Neuropathological Heterogeneity of Dementia Due to Combined Pathology in Aged Patients: Clinicopathological Findings in the Vallecas Alzheimer's Reina Sofía Cohort.
Burgueño-García I, López-Martínez MJ, Uceda-Heras A, García-Carracedo L, Zea-Sevilla MA, Rodrigo-Lara H, Rego-García I, Saiz-Aúz L, Ruiz-Valderrey P, López-González FJ, Guerra-Martín V, Rábano A
Journal of clinical medicine 2024 Nov 10;13(22)
Journal of clinical medicine 2024 Nov 10;13(22)
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Wang Z, Bi M, Zhe X, Wang X, Dai B, Han X, Ren B, Liang H, Liu D
Cell death discovery 2024 Feb 22;10(1):95
Cell death discovery 2024 Feb 22;10(1):95
Beneficial Effects of Echinacoside on Cognitive Impairment and Diabetes in Type 2 Diabetic db/db Mice.
Qin F, Yan Y, Yang N, Hao Y
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2024 Aug;132(8):420-430
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2024 Aug;132(8):420-430
The mechanism of chemokine receptor ACKR2 in cognitive impairment in young rats with traumatic brain injury.
Quan L, Zhao Y, Ouyang C, Ying D, Xiong Z, Li X, Liao Z, Luo J, Liu H
American journal of translational research 2023;15(3):1654-1666
American journal of translational research 2023;15(3):1654-1666
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Meng Q, Chao Y, Zhang S, Ding X, Feng H, Zhang C, Liu B, Zhu W, Li Y, Zhang Q, Tong H, Wu L, Bian H
Molecular brain 2023 Nov 20;16(1):80
Molecular brain 2023 Nov 20;16(1):80
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway.
Wang G, Shen X, Song X, Wang N, Wo X, Gao Y
Neurotoxicology 2023 Mar;95:12-22
Neurotoxicology 2023 Mar;95:12-22
Overexpression of fibroblast growth factor 13 ameliorates amyloid-β-induced neuronal damage.
Li RM, Xiao L, Zhang T, Ren D, Zhu H
Neural regeneration research 2023 Jun;18(6):1347-1353
Neural regeneration research 2023 Jun;18(6):1347-1353
Amelioration of central neurodegeneration by docosahexaenoic acid in trigeminal neuralgia rats through the regulation of central neuroinflammation.
Mu G, Ren C, Zhang Y, Lu B, Feng J, Wu D, Xu X, Ou C
International immunopharmacology 2023 Jan;114:109544
International immunopharmacology 2023 Jan;114:109544
The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model.
Li Y, Xu J, Guo X, Li Z, Cao L, Liu S, Guo Y, Wang G, Luo Y, Zhang Z, Wei X, Zhao Y, Liu T, Wang X, Xia H, Kuang M, Guo Q, Li J, Chen L, Wang Y, Li Q, Wang F, Liu Q, You F
Genome biology 2023 Feb 1;24(1):20
Genome biology 2023 Feb 1;24(1):20
miRNA-137-5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin-specific peptidase 30.
Jiang Y, Bian W, Chen J, Cao X, Dong C, Xiao Y, Xu B, Sun X
Animal models and experimental medicine 2023 Dec;6(6):526-536
Animal models and experimental medicine 2023 Dec;6(6):526-536
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors.
Zhang T, Wang WL, Liu TJ, Lu S, Bian YC, Xiao R, Zhang CL
Biological & pharmaceutical bulletin 2022;45(11):1616-1626
Biological & pharmaceutical bulletin 2022;45(11):1616-1626
Low-Intensity Focused Ultrasound Alleviates Chronic Neuropathic Pain-Induced Allodynia by Inhibiting Neuroplasticity in the Anterior Cingulate Cortex.
Wang B, Chen MX, Chen SC, Feng XJ, Liao YH, Zhao YX, Tie JS, Liu Y, Ao LJ
Neural plasticity 2022;2022:6472475
Neural plasticity 2022;2022:6472475
Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model.
Luo K, Wang Y, Chen WS, Feng X, Liao Y, Chen S, Liu Y, Liao C, Chen M, Ao L
Neural plasticity 2022;2022:5241449
Neural plasticity 2022;2022:5241449
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.
Pan L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G, Zhang Z
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.
Zeng L, Jiang H, Ashraf GM, Liu J, Wang L, Zhao K, Liu M, Li Z, Liu R
Molecular therapy. Nucleic acids 2022 Mar 8;27:256-275
Molecular therapy. Nucleic acids 2022 Mar 8;27:256-275
Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.
Ali TFS, Ciftci HI, Radwan MO, Roshdy E, Shawky AM, Abourehab MAS, Tateishi H, Otsuka M, Fujita M
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Han QJ, Han G, Peng J, Tang Z
Free radical biology & medicine 2022 Feb 1;179:416-417
Free radical biology & medicine 2022 Feb 1;179:416-417
Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis.
Chong S, Chen G, Dang Z, Niu F, Zhang L, Ma H, Zhao Y
Bioengineered 2022 Apr;13(4):8747-8758
Bioengineered 2022 Apr;13(4):8747-8758
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.
Yang XB, Zu HB, Zhao YF, Yao K
Frontiers in aging neuroscience 2021;13:766410
Frontiers in aging neuroscience 2021;13:766410
ErbB4 mediates amyloid β-induced neurotoxicity through JNK/tau pathway activation: Implications for Alzheimer's disease.
Zhang H, Zhang L, Zhou D, Li H, Xu Y
The Journal of comparative neurology 2021 Oct;529(15):3497-3512
The Journal of comparative neurology 2021 Oct;529(15):3497-3512
Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force.
Wang Y, Zhou J, Tang C, Yu J, Zhu W, Guo J, Wang Y
Journal of cellular physiology 2021 Mar;236(3):2156-2168
Journal of cellular physiology 2021 Mar;236(3):2156-2168
The effects of antimony on Alzheimer's disease-like pathological changes in mice brain.
Xu S, Yang Z, Zhi Y, Yu S, Zhang T, Jiang J, Tang J, He H, Lu M, Wang X, Wu Q, Zhao X
The Science of the total environment 2021 Mar 15;760:143235
The Science of the total environment 2021 Mar 15;760:143235
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.
Perez Garcia G, De Gasperi R, Gama Sosa MA, Perez GM, Otero-Pagan A, Pryor D, Abutarboush R, Kawoos U, Hof PR, Dickstein DL, Cook DG, Gandy S, Ahlers ST, Elder GA
Acta neuropathologica communications 2021 Mar 1;9(1):33
Acta neuropathologica communications 2021 Mar 1;9(1):33
Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro.
Nie F, Zhang Q, Ma J, Wang P, Gu R, Han J, Zhang R
Journal of neurochemistry 2021 Jun;157(6):1745-1758
Journal of neurochemistry 2021 Jun;157(6):1745-1758
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z
Free radical biology & medicine 2021 Jan;162:181-190
Free radical biology & medicine 2021 Jan;162:181-190
NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110964
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HT-1080 cells were subjected to SDS PAGE followed by western blot with 10274-1-AP(TAU antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 10274-1-AP(TAU antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The TAU antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TAU. This antibody recognizes human, mouse, rat antigen. The TAU antibody has been validated for the following applications: ELISA, WB, IHC analysis.