ABIN362069

antibody from antibodies-online

Targeting: MAPT DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN362069

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN362069, RRID:AB_10952152

Product name

anti-Microtubule-Associated Protein tau (MAPT) (pSer235) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around phosphorylation site of pSer235 (P-K-S (p) -P-S) derived from Human Tau. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pSer235

Isotype

IgG

Vial size

50 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.

Bertrand J, Sénéchal P, Zummo-Soucy M, Plouffe V, Leclerc N
Journal of neurochemistry 2010 Sep 1;114(5):1353-67

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Promotion of hyperphosphorylation by frontotemporal dementia tau mutations.

Alonso Adel C, Mederlyova A, Novak M, Grundke-Iqbal I, Iqbal K
The Journal of biological chemistry 2004 Aug 13;279(33):34873-81

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Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.

Sengupta A, Kabat J, Novak M, Wu Q, Grundke-Iqbal I, Iqbal K
Archives of biochemistry and biophysics 1998 Sep 15;357(2):299-309