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LearnMN1000
antibody from Invitrogen Antibodies
Targeting: MAPT
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
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- Antibody Data
- Antigen structure
- References [234]
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- Other assay [14]
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- Product number
- MN1000 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Tau Monoclonal Antibody (HT7)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MN1000 recognizes normal Tau from human and bovine brain and PHF-Tau. No cross reactivity with Tau from rat brain has been observed. The epitope of this antibody has been mapped on human Tau between residue 159 and 163 (numbering according to human Tau40), corresponding to the amino acid sequence PPGQK. MN1000 detects Tau which has a predicted molecular weight of approximately 79 kDa. Purity is >95% as determined by SDS-PAGE.
- Reactivity
- Human, Bovine
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- HT7
- Vial size
- 100 µg
- Concentration
- 0.2 mg/mL
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references Dysfunction of the retromer complex system contributes to amyloid and tau pathology in a stem cell model of Down syndrome.
UPR(mt) activation improves pathological alterations in cellular models of mitochondrial diseases.
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau.
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.
Tau N-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model.
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis.
Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease.
Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau.
Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies.
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia.
Reduction of pTau and APP levels in mammalian brain after low-dose radiation.
Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.
Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid.
Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer's disease neurons.
Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration.
Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer's Disease.
Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice.
Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Modulating disease-relevant tau oligomeric strains by small molecules.
Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer's Disease is Affected by Aβ-ImmunoTherapy and Cognitive Stimulation.
Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.
Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex.
Tau affects P53 function and cell fate during the DNA damage response.
Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration.
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.
4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons.
Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.
Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.
Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia.
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Tau reduction in aged mice does not impact Microangiopathy.
Fyn Kinase Controls Tau Aggregation In Vivo.
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity.
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.
Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network.
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.
Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology.
An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development.
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.
Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans.
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease.
Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice.
Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.
Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.
Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin.
Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease.
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease.
Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer's Disease.
Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression.
Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.
Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model.
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry.
Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.
NAD(+) supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
Tau protein aggregation is associated with cellular senescence in the brain.
Tau protein liquid-liquid phase separation can initiate tau aggregation.
Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.
Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned?
Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.
Dyrk1 inhibition improves Alzheimer's disease-like pathology.
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
A validated antibody panel for the characterization of tau post-translational modifications.
Tau-positive nuclear indentations in P301S tauopathy mice.
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
MAP2 Splicing is Altered in Huntington's Disease.
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
Cryo-EM structures of tau filaments from Alzheimer's disease.
HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease.
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.
Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy.
Tau deletion promotes brain insulin resistance.
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Chemical and neuropathological analyses of an Alzheimer's disease patient treated with solanezumab.
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION.
α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.
Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2.
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling.
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model.
Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease.
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition.
Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.
Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain.
Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.
Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Depletion of microglia and inhibition of exosome synthesis halt tau propagation.
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent.
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
Piericidin A aggravates Tau pathology in P301S transgenic mice.
Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn.
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.
Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease.
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy.
Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.
Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.
PINCH in the cellular stress response to tau-hyperphosphorylation.
Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.
Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease.
Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations.
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Neurochemical profile of dementia pugilistica.
Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Synaptic alterations in the rTg4510 mouse model of tauopathy.
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S.
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Hippocampal BDNF expression in a tau transgenic mouse model.
Hippocampal BDNF expression in a tau transgenic mouse model.
Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice.
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Propagation of tau pathology in a model of early Alzheimer's disease.
Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells.
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
Frontal cortex neuropathology in dementia pugilistica.
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.
Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model.
Morin attenuates tau hyperphosphorylation by inhibiting GSK3β.
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity.
6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors.
Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
Nuclear tau, a key player in neuronal DNA protection.
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.
Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.
Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer.
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins.
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.
Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.
Transmission and spreading of tauopathy in transgenic mouse brain.
A cellular model to monitor proteasome dysfunction by alpha-synuclein.
Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations.
ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification.
Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease.
Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease.
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Curtis ME, Smith T, Blass BE, Praticò D
Alzheimer's & dementia (New York, N. Y.) 2022;8(1):e12334
Alzheimer's & dementia (New York, N. Y.) 2022;8(1):e12334
UPR(mt) activation improves pathological alterations in cellular models of mitochondrial diseases.
Suárez-Rivero JM, Pastor-Maldonado CJ, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Reche-López D, Cilleros-Holgado P, Piñero-Perez R, Sánchez-Alcázar JA
Orphanet journal of rare diseases 2022 May 17;17(1):204
Orphanet journal of rare diseases 2022 May 17;17(1):204
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Stojakovic A, Chang SY, Nesbitt J, Pichurin NP, Ostroot MA, Aikawa T, Kanekiyo T, Trushina E
Journal of Alzheimer's disease : JAD 2021;79(1):335-353
Journal of Alzheimer's disease : JAD 2021;79(1):335-353
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Omoluabi T, Torraville SE, Maziar A, Ghosh A, Power KD, Reinhardt C, Harley CW, Yuan Q
Alzheimer's & dementia (New York, N. Y.) 2021;7(1):e12231
Alzheimer's & dementia (New York, N. Y.) 2021;7(1):e12231
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Javonillo DI, Tran KM, Phan J, Hingco E, Kramár EA, da Cunha C, Forner S, Kawauchi S, Milinkeviciute G, Gomez-Arboledas A, Neumann J, Banh CE, Huynh M, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN, LaFerla FM
Frontiers in neuroscience 2021;15:785276
Frontiers in neuroscience 2021;15:785276
Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau.
Filippone A, Smith T, Pratico D
Journal of inflammation research 2021;14:7455-7465
Journal of inflammation research 2021;14:7455-7465
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.
Shrigley S, Nilsson F, Mattsson B, Fiorenzano A, Mudannayake J, Bruzelius A, Ottosson DR, Björklund A, Hoban DB, Parmar M
Journal of Parkinson's disease 2021;11(2):515-528
Journal of Parkinson's disease 2021;11(2):515-528
Tau N-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model.
Wu C, Zhao J, Wu Q, Tan Q, Liu Q, Xiao S
International journal of molecular sciences 2021 Sep 8;22(18)
International journal of molecular sciences 2021 Sep 8;22(18)
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Nies SH, Takahashi H, Herber CS, Huttner A, Chase A, Strittmatter SM
The Journal of biological chemistry 2021 Oct;297(4):101159
The Journal of biological chemistry 2021 Oct;297(4):101159
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Pérez MJ, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, Al-Shaana R, Kaeser SA, Fraschka SA, Jucker M, Zeviani M, Viscomi C, Deleidi M
Molecular psychiatry 2021 Oct;26(10):5733-5750
Molecular psychiatry 2021 Oct;26(10):5733-5750
Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis.
Huang HJ, Chen JL, Liao JF, Chen YH, Chieu MW, Ke YY, Hsu CC, Tsai YC, Hsieh-Li HM
BMC complementary medicine and therapies 2021 Oct 9;21(1):259
BMC complementary medicine and therapies 2021 Oct 9;21(1):259
Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease.
Blumenstock S, Schulz-Trieglaff EK, Voelkl K, Bolender AL, Lapios P, Lindner J, Hipp MS, Hartl FU, Klein R, Dudanova I
The EMBO journal 2021 Oct 1;40(19):e107260
The EMBO journal 2021 Oct 1;40(19):e107260
Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau.
Caroux E, Redeker V, Madiona K, Melki R
The Journal of biological chemistry 2021 Nov;297(5):101252
The Journal of biological chemistry 2021 Nov;297(5):101252
Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.
Di Meco A, Jelinek J, Lauretti E, Curtis ME, Issa JJ, Praticò D
Molecular psychiatry 2021 Nov;26(11):7006-7019
Molecular psychiatry 2021 Nov;26(11):7006-7019
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM
Cell 2021 May 13;184(10):2696-2714.e25
Cell 2021 May 13;184(10):2696-2714.e25
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T
Molecular neurodegeneration 2021 Mar 22;16(1):18
Molecular neurodegeneration 2021 Mar 22;16(1):18
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA
Acta neuropathologica communications 2021 Mar 12;9(1):41
Acta neuropathologica communications 2021 Mar 12;9(1):41
Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Wu D, Gao D, Yu H, Pi G, Xiong R, Lei H, Wang X, Liu E, Ye J, Yu H, Gao Y, He T, Jiang T, Sun F, Su J, Song G, Peng W, Yang Y, Wang JZ
Clinical and translational medicine 2021 Jun;11(6):e428
Clinical and translational medicine 2021 Jun;11(6):e428
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT
Journal of neuroinflammation 2021 Jun 11;18(1):131
Journal of neuroinflammation 2021 Jun 11;18(1):131
Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies.
Shih PY, Kreir M, Kumar D, Seibt F, Pestana F, Schmid B, Holst B, Clausen C, Steeg R, Fischer B, Pita-Almenar J, Ebneth A, Cabrera-Socorro A
Stem cell research 2021 Jul;54:102386
Stem cell research 2021 Jul;54:102386
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Bichmann M, Prat Oriol N, Ercan-Herbst E, Schöndorf DC, Gomez Ramos B, Schwärzler V, Neu M, Schlüter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, Ehrnhoefer DE
Molecular neurodegeneration 2021 Jul 2;16(1):46
Molecular neurodegeneration 2021 Jul 2;16(1):46
Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia.
García-Lara E, Aguirre S, Clotet N, Sawkulycz X, Bartra C, Almenara-Fuentes L, Suñol C, Corpas R, Olah P, Tripon F, Crauciuc A, Slevin M, Sanfeliu C
Biomedicines 2021 Jul 16;9(7)
Biomedicines 2021 Jul 16;9(7)
Reduction of pTau and APP levels in mammalian brain after low-dose radiation.
Iacono D, Murphy EK, Avantsa SS, Perl DP, Day RM
Scientific reports 2021 Jan 26;11(1):2215
Scientific reports 2021 Jan 26;11(1):2215
Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.
Chen G, Kang SS, Wang Z, Ahn EH, Xia Y, Liu X, Sandoval IM, Manfredsson FP, Zhang Z, Ye K
Science advances 2021 Apr;7(16)
Science advances 2021 Apr;7(16)
Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid.
Triana-Baltzer G, Van Kolen K, Theunis C, Moughadam S, Slemmon R, Mercken M, Galpern W, Sun H, Kolb H
Journal of Alzheimer's disease : JAD 2020;77(4):1417-1430
Journal of Alzheimer's disease : JAD 2020;77(4):1417-1430
Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer's disease neurons.
Whiten DR, Brownjohn PW, Moore S, De S, Strano A, Zuo Y, Haneklaus M, Klenerman D, Livesey FJ
Brain communications 2020;2(2):fcaa146
Brain communications 2020;2(2):fcaa146
Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration.
Ye J, Yin Y, Yin Y, Zhang H, Wan H, Wang L, Zuo Y, Gao D, Li M, Li J, Liu Y, Ke D, Wang JZ
Aging cell 2020 Sep;19(9):e13209
Aging cell 2020 Sep;19(9):e13209
Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer's Disease.
Huang H, Camats-Perna J, Medeiros R, Anggono V, Widagdo J
eNeuro 2020 Sep Oct;7(5)
eNeuro 2020 Sep Oct;7(5)
Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice.
Roda AR, Montoliu-Gaya L, Serra-Mir G, Villegas S
International journal of molecular sciences 2020 Sep 10;21(18)
International journal of molecular sciences 2020 Sep 10;21(18)
Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Li JG, Chiu J, Praticò D
Molecular psychiatry 2020 Oct;25(10):2630-2640
Molecular psychiatry 2020 Oct;25(10):2630-2640
Modulating disease-relevant tau oligomeric strains by small molecules.
Lo Cascio F, Garcia S, Montalbano M, Puangmalai N, McAllen S, Pace A, Palumbo Piccionello A, Kayed R
The Journal of biological chemistry 2020 Oct 30;295(44):14807-14825
The Journal of biological chemistry 2020 Oct 30;295(44):14807-14825
Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer's Disease is Affected by Aβ-ImmunoTherapy and Cognitive Stimulation.
Roda AR, Esquerda-Canals G, Martí-Clúa J, Villegas S
Pharmaceutics 2020 Oct 2;12(10)
Pharmaceutics 2020 Oct 2;12(10)
Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.
Murphy EK, Iacono D, Pan H, Grimes JB, Parks S, Raiciulescu S, Leonessa F, Perl DP
Scientific reports 2020 Oct 15;10(1):17446
Scientific reports 2020 Oct 15;10(1):17446
Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex.
Fiock KL, Smalley ME, Crary JF, Pasca AM, Hefti MM
eNeuro 2020 May Jun;7(3)
eNeuro 2020 May Jun;7(3)
Tau affects P53 function and cell fate during the DNA damage response.
Sola M, Magrin C, Pedrioli G, Pinton S, Salvadè A, Papin S, Paganetti P
Communications biology 2020 May 19;3(1):245
Communications biology 2020 May 19;3(1):245
Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration.
Nakata S, Price A, Eberhart C, Morris M
Journal of neuropathology and experimental neurology 2020 May 1;79(5):493-499
Journal of neuropathology and experimental neurology 2020 May 1;79(5):493-499
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J
International journal of molecular sciences 2020 Jun 25;21(12)
International journal of molecular sciences 2020 Jun 25;21(12)
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF
Scientific reports 2020 Jul 30;10(1):12827
Scientific reports 2020 Jul 30;10(1):12827
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
Nachman E, Wentink AS, Madiona K, Bousset L, Katsinelos T, Allinson K, Kampinga H, McEwan WA, Jahn TR, Melki R, Mogk A, Bukau B, Nussbaum-Krammer C
The Journal of biological chemistry 2020 Jul 10;295(28):9676-9690
The Journal of biological chemistry 2020 Jul 10;295(28):9676-9690
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.
Tang SJ, Fesharaki-Zadeh A, Takahashi H, Nies SH, Smith LM, Luo A, Chyung A, Chiasseu M, Strittmatter SM
Acta neuropathologica communications 2020 Jul 1;8(1):96
Acta neuropathologica communications 2020 Jul 1;8(1):96
4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration.
Saijo E, Metrick MA 2nd, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B
Acta neuropathologica 2020 Jan;139(1):63-77
Acta neuropathologica 2020 Jan;139(1):63-77
Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons.
Alquezar C, Felix JB, McCandlish E, Buckley BT, Caparros-Lefebvre D, Karch CM, Golbe LI, Kao AW
Scientific reports 2020 Jan 17;10(1):569
Scientific reports 2020 Jan 17;10(1):569
Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier.
Liu Y, Zhang S, Li X, Liu E, Wang X, Zhou Q, Ye J, Wang JZ
Bioscience reports 2020 Feb 28;40(2)
Bioscience reports 2020 Feb 28;40(2)
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.
Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, Zheng Y, Fu L, Yu B, Zhang H, Wu J, Yu X, Wu H, Kong W
Journal of neuroinflammation 2020 Feb 24;17(1):72
Journal of neuroinflammation 2020 Feb 24;17(1):72
Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.
Iacono D, Lee P, Edlow BL, Gray N, Fischl B, Kenney K, Lew HL, Lozanoff S, Liacouras P, Lichtenberger J, Dams-O'Connor K, Cifu D, Hinds SR, Perl DP
Journal of neuropathology and experimental neurology 2020 Feb 1;79(2):144-162
Journal of neuropathology and experimental neurology 2020 Feb 1;79(2):144-162
Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia.
Lemke N, Melis V, Lauer D, Magbagbeolu M, Neumann B, Harrington CR, Riedel G, Wischik CM, Theuring F, Schwab K
The Journal of biological chemistry 2020 Dec 25;295(52):18508-18523
The Journal of biological chemistry 2020 Dec 25;295(52):18508-18523
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Wu Z, Liu X, Cheng L, Ye K
Cell death & disease 2020 Dec 12;11(12):1058
Cell death & disease 2020 Dec 12;11(12):1058
Tau reduction in aged mice does not impact Microangiopathy.
Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT
Acta neuropathologica communications 2020 Aug 18;8(1):137
Acta neuropathologica communications 2020 Aug 18;8(1):137
Fyn Kinase Controls Tau Aggregation In Vivo.
Briner A, Götz J, Polanco JC
Cell reports 2020 Aug 18;32(7):108045
Cell reports 2020 Aug 18;32(7):108045
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Apr 22;40(17):3491-3501
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Apr 22;40(17):3491-3501
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Chadchankar J, Korboukh V, Conway LC, Wobst HJ, Walker CA, Doig P, Jacobsen SJ, Brandon NJ, Moss SJ, Wang Q
PloS one 2019;14(11):e0225145
PloS one 2019;14(11):e0225145
Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity.
Hill E, Karikari TK, Moffat KG, Richardson MJE, Wall MJ
eNeuro 2019 Sep Oct;6(5)
eNeuro 2019 Sep Oct;6(5)
Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.
Di Meco A, Li JG, Barrero C, Merali S, Praticò D
Molecular psychiatry 2019 Nov;24(11):1696-1706
Molecular psychiatry 2019 Nov;24(11):1696-1706
Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network.
Yu A, Fox SG, Cavallini A, Kerridge C, O'Neill MJ, Wolak J, Bose S, Morimoto RI
The Journal of biological chemistry 2019 May 10;294(19):7917-7930
The Journal of biological chemistry 2019 May 10;294(19):7917-7930
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.
Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi K, Mandelkow EM, Encalada SE, Kao AW
Human molecular genetics 2019 May 1;28(9):1498-1514
Human molecular genetics 2019 May 1;28(9):1498-1514
Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology.
Gangolli M, Benetatos J, Esparza TJ, Fountain EM, Seneviratne S, Brody DL
Journal of neurotrauma 2019 Mar 1;36(5):735-755
Journal of neurotrauma 2019 Mar 1;36(5):735-755
An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development.
Ghosh A, Torraville SE, Mukherjee B, Walling SG, Martin GM, Harley CW, Yuan Q
Alzheimer's research & therapy 2019 Jul 3;11(1):59
Alzheimer's research & therapy 2019 Jul 3;11(1):59
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
Evans HT, Benetatos J, van Roijen M, Bodea LG, Götz J
The EMBO journal 2019 Jul 1;38(13):e101174
The EMBO journal 2019 Jul 1;38(13):e101174
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Paonessa F, Evans LD, Solanki R, Larrieu D, Wray S, Hardy J, Jackson SP, Livesey FJ
Cell reports 2019 Jan 15;26(3):582-593.e5
Cell reports 2019 Jan 15;26(3):582-593.e5
Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.
Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, Zhu L, Qiao Y, Sun Q, Qin W, Zhao Q, Jia J, Wei C
Aging cell 2019 Aug;18(4):e12978
Aging cell 2019 Aug;18(4):e12978
Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans.
Weisová P, Cehlár O, Škrabana R, Žilková M, Filipčík P, Kováčech B, Prčina M, Wojčiaková Ľ, Fialová Ľ, Smolek T, Kontseková E, Žilka N, Novák M
Acta neuropathologica communications 2019 Aug 7;7(1):129
Acta neuropathologica communications 2019 Aug 7;7(1):129
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Jadiya P, Kolmetzky DW, Tomar D, Di Meco A, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Praticò D, Elrod JW
Nature communications 2019 Aug 29;10(1):3885
Nature communications 2019 Aug 29;10(1):3885
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease.
Kraus A, Saijo E, Metrick MA 2nd, Newell K, Sigurdson CJ, Zanusso G, Ghetti B, Caughey B
Acta neuropathologica 2019 Apr;137(4):585-598
Acta neuropathologica 2019 Apr;137(4):585-598
Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice.
Yu KC, Kwan P, Cheung SKK, Ho A, Baum L
Translational neuroscience 2018;9:54-60
Translational neuroscience 2018;9:54-60
Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.
Li C, Götz J
Journal of Alzheimer's disease : JAD 2018;64(1):205-221
Journal of Alzheimer's disease : JAD 2018;64(1):205-221
Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.
Wang X, Smith K, Pearson M, Hughes A, Cosden ML, Marcus J, Hess JF, Savage MJ, Rosahl T, Smith SM, Schachter JB, Uslaner JM
PloS one 2018;13(4):e0195486
PloS one 2018;13(4):e0195486
Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin.
Mendsaikhan A, Takeuchi S, Walker DG, Tooyama I
Frontiers in molecular neuroscience 2018;11:470
Frontiers in molecular neuroscience 2018;11:470
Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease.
Dumbacher M, Van Dooren T, Princen K, De Witte K, Farinelli M, Lievens S, Tavernier J, Dehaen W, Wera S, Winderickx J, Allasia S, Kilonda A, Spieser S, Marchand A, Chaltin P, Hoogenraad CC, Griffioen G
Molecular neurodegeneration 2018 Sep 26;13(1):50
Molecular neurodegeneration 2018 Sep 26;13(1):50
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease.
Hopp SC, Lin Y, Oakley D, Roe AD, DeVos SL, Hanlon D, Hyman BT
Journal of neuroinflammation 2018 Sep 18;15(1):269
Journal of neuroinflammation 2018 Sep 18;15(1):269
Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.
Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson MP
Neurobiology of aging 2018 Oct;70:160-169
Neurobiology of aging 2018 Oct;70:160-169
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ
Nature 2018 Oct;562(7728):578-582
Nature 2018 Oct;562(7728):578-582
Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer's Disease.
Ahmad W
Experimental brain research 2018 Nov;236(11):2857-2866
Experimental brain research 2018 Nov;236(11):2857-2866
Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression.
Chen HH, Liu P, Auger P, Lee SH, Adolfsson O, Rey-Bellet L, Lafrance-Vanasse J, Friedman BA, Pihlgren M, Muhs A, Pfeifer A, Ernst J, Ayalon G, Wildsmith KR, Beach TG, van der Brug MP
Scientific reports 2018 Nov 13;8(1):16725
Scientific reports 2018 Nov 13;8(1):16725
Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.
Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB
Stem cell reports 2018 Mar 13;10(3):1046-1058
Stem cell reports 2018 Mar 13;10(3):1046-1058
Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model.
Li Y, Chen C, Xu D, Poon CY, Ho SL, Zheng R, Liu Q, Song G, Li HW, Wong MS
ACS omega 2018 Jun 30;3(6):6812-6819
ACS omega 2018 Jun 30;3(6):6812-6819
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B
Acta neuropathologica communications 2018 Jun 29;6(1):52
Acta neuropathologica communications 2018 Jun 29;6(1):52
Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry.
Huang RY, Iacob RE, Sankaranarayanan S, Yang L, Ahlijanian M, Tao L, Tymiak AA, Chen G
Journal of the American Society for Mass Spectrometry 2018 Jan;29(1):174-182
Journal of the American Society for Mass Spectrometry 2018 Jan;29(1):174-182
Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.
Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, Beauvais G, Zwaka TP, Ozelius LJ, Blitzer RD, Gonzalez-Alegre P, Ehrlich ME
PLoS genetics 2018 Jan;14(1):e1007169
PLoS genetics 2018 Jan;14(1):e1007169
NAD(+) supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 20;115(8):E1876-E1885
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 20;115(8):E1876-E1885
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.
Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, Hisanaga SI
The Journal of biological chemistry 2018 Feb 2;293(5):1781-1793
The Journal of biological chemistry 2018 Feb 2;293(5):1781-1793
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
Falcon B, Noad J, McMahon H, Randow F, Goedert M
The Journal of biological chemistry 2018 Feb 16;293(7):2438-2451
The Journal of biological chemistry 2018 Feb 16;293(7):2438-2451
Tau protein aggregation is associated with cellular senescence in the brain.
Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME
Aging cell 2018 Dec;17(6):e12840
Aging cell 2018 Dec;17(6):e12840
Tau protein liquid-liquid phase separation can initiate tau aggregation.
Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT
The EMBO journal 2018 Apr 3;37(7)
The EMBO journal 2018 Apr 3;37(7)
Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.
Nicholls SB, DeVos SL, Commins C, Nobuhara C, Bennett RE, Corjuc DL, Maury E, Eftekharzadeh B, Akingbade O, Fan Z, Roe AD, Takeda S, Wegmann S, Hyman BT
PloS one 2017;12(5):e0177914
PloS one 2017;12(5):e0177914
Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned?
Drouin-Ouellet J, Pircs K, Barker RA, Jakobsson J, Parmar M
Frontiers in neuroscience 2017;11:530
Frontiers in neuroscience 2017;11:530
Pimozide reduces toxic forms of tau in TauC3 mice via 5' adenosine monophosphate-activated protein kinase-mediated autophagy.
Kim YD, Jeong EI, Nah J, Yoo SM, Lee WJ, Kim Y, Moon S, Hong SH, Jung YK
Journal of neurochemistry 2017 Sep;142(5):734-746
Journal of neurochemistry 2017 Sep;142(5):734-746
Dyrk1 inhibition improves Alzheimer's disease-like pathology.
Branca C, Shaw DM, Belfiore R, Gokhale V, Shaw AY, Foley C, Smith B, Hulme C, Dunckley T, Meechoovet B, Caccamo A, Oddo S
Aging cell 2017 Oct;16(5):1146-1154
Aging cell 2017 Oct;16(5):1146-1154
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Lathuilière A, Valdés P, Papin S, Cacquevel M, Maclachlan C, Knott GW, Muhs A, Paganetti P, Schneider BL
Scientific reports 2017 Oct 19;7(1):13556
Scientific reports 2017 Oct 19;7(1):13556
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.
Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L
Stem cell reports 2017 Oct 10;9(4):1221-1233
Stem cell reports 2017 Oct 10;9(4):1221-1233
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME
Acta neuropathologica 2017 Nov;134(5):769-788
Acta neuropathologica 2017 Nov;134(5):769-788
A validated antibody panel for the characterization of tau post-translational modifications.
Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, Matthes F, Krauss S, Reinhardt P, Fulle S, Ehrnhoefer DE
Molecular neurodegeneration 2017 Nov 21;12(1):87
Molecular neurodegeneration 2017 Nov 21;12(1):87
Tau-positive nuclear indentations in P301S tauopathy mice.
Fernández-Nogales M, Santos-Galindo M, Merchán-Rubira J, Hoozemans JJM, Rábano A, Ferrer I, Avila J, Hernández F, Lucas JJ
Brain pathology (Zurich, Switzerland) 2017 May;27(3):314-322
Brain pathology (Zurich, Switzerland) 2017 May;27(3):314-322
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM, Alzheimer’s Disease Neuroimaging Initiative
Acta neuropathologica 2017 May;133(5):785-807
Acta neuropathologica 2017 May;133(5):785-807
MAP2 Splicing is Altered in Huntington's Disease.
Cabrera JR, Lucas JJ
Brain pathology (Zurich, Switzerland) 2017 Mar;27(2):181-189
Brain pathology (Zurich, Switzerland) 2017 Mar;27(2):181-189
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K
Nature communications 2017 Mar 27;8:14740
Nature communications 2017 Mar 27;8:14740
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S
The American journal of pathology 2017 Jun;187(6):1399-1412
The American journal of pathology 2017 Jun;187(6):1399-1412
Cryo-EM structures of tau filaments from Alzheimer's disease.
Fitzpatrick AWP, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SHW
Nature 2017 Jul 13;547(7662):185-190
Nature 2017 Jul 13;547(7662):185-190
HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.
García-Ayllón MS, Botella-López A, Cuchillo-Ibañez I, Rábano A, Andreasen N, Blennow K, Ávila J, Sáez-Valero J
Molecular neurobiology 2017 Jan;54(1):188-199
Molecular neurobiology 2017 Jan;54(1):188-199
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Laurent C, Dorothée G, Hunot S, Martin E, Monnet Y, Duchamp M, Dong Y, Légeron FP, Leboucher A, Burnouf S, Faivre E, Carvalho K, Caillierez R, Zommer N, Demeyer D, Jouy N, Sazdovitch V, Schraen-Maschke S, Delarasse C, Buée L, Blum D
Brain : a journal of neurology 2017 Jan;140(1):184-200
Brain : a journal of neurology 2017 Jan;140(1):184-200
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC
Proceedings of the National Academy of Sciences of the United States of America 2017 Jan 17;114(3):574-579
Proceedings of the National Academy of Sciences of the United States of America 2017 Jan 17;114(3):574-579
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Di Meco A, Li JG, Blass BE, Abou-Gharbia M, Lauretti E, Praticò D
Biological psychiatry 2017 Jan 15;81(2):92-100
Biological psychiatry 2017 Jan 15;81(2):92-100
Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease.
Lauretti E, Praticò D
Scientific reports 2017 Dec 7;7(1):17134
Scientific reports 2017 Dec 7;7(1):17134
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.
Drouin-Ouellet J, Lau S, Brattås PL, Rylander Ottosson D, Pircs K, Grassi DA, Collins LM, Vuono R, Andersson Sjöland A, Westergren-Thorsson G, Graff C, Minthon L, Toresson H, Barker RA, Jakobsson J, Parmar M
EMBO molecular medicine 2017 Aug;9(8):1117-1131
EMBO molecular medicine 2017 Aug;9(8):1117-1131
Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy.
Lauretti E, Iuliano L, Praticò D
Annals of clinical and translational neurology 2017 Aug;4(8):564-574
Annals of clinical and translational neurology 2017 Aug;4(8):564-574
Tau deletion promotes brain insulin resistance.
Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D
The Journal of experimental medicine 2017 Aug 7;214(8):2257-2269
The Journal of experimental medicine 2017 Aug 7;214(8):2257-2269
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.
Bodea LG, Evans HT, Van der Jeugd A, Ittner LM, Delerue F, Kril J, Halliday G, Hodges J, Kiernan MC, Götz J
Aging cell 2017 Apr;16(2):377-386
Aging cell 2017 Apr;16(2):377-386
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Li JG, Barrero C, Merali S, Praticò D
Scientific reports 2017 Apr 6;7:46002
Scientific reports 2017 Apr 6;7:46002
Chemical and neuropathological analyses of an Alzheimer's disease patient treated with solanezumab.
Roher AE, Maarouf CL, Kokjohn TA, Belden C, Serrano G, Sabbagh MS, Beach TG
American journal of neurodegenerative disease 2016;5(4):158-170
American journal of neurodegenerative disease 2016;5(4):158-170
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT
Annals of neurology 2016 Sep;80(3):355-67
Annals of neurology 2016 Sep;80(3):355-67
Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION.
Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A
The Journal of biological chemistry 2016 Oct 21;291(43):22714-22720
The Journal of biological chemistry 2016 Oct 21;291(43):22714-22720
α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.
Kuan WL, Bennett N, He X, Skepper JN, Martynyuk N, Wijeyekoon R, Moghe PV, Williams-Gray CH, Barker RA
Experimental neurology 2016 Nov;285(Pt A):72-81
Experimental neurology 2016 Nov;285(Pt A):72-81
Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL
Developmental dynamics : an official publication of the American Association of Anatomists 2016 May;245(5):614-26
Developmental dynamics : an official publication of the American Association of Anatomists 2016 May;245(5):614-26
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Di Meco A, Joshi YB, Lauretti E, Praticò D
Molecular psychiatry 2016 Mar;21(3):403-10
Molecular psychiatry 2016 Mar;21(3):403-10
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Gorsky MK, Burnouf S, Dols J, Mandelkow E, Partridge L
Scientific reports 2016 Mar 4;6:22685
Scientific reports 2016 Mar 4;6:22685
Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2.
Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, Wu D, Pi G, Lu C, Zhou XW, Yang Y, Wang JZ
Scientific reports 2016 Jun 9;6:27283
Scientific reports 2016 Jun 9;6:27283
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L
Molecular neurodegeneration 2016 Jun 29;11(1):47
Molecular neurodegeneration 2016 Jun 29;11(1):47
Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling.
Yin Y, Gao D, Wang Y, Wang ZH, Wang X, Ye J, Wu D, Fang L, Pi G, Yang Y, Wang XC, Lu C, Ye K, Wang JZ
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):E3773-81
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):E3773-81
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M
Acta neuropathologica communications 2016 Jun 23;4(1):63
Acta neuropathologica communications 2016 Jun 23;4(1):63
Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model.
Schoch KM, DeVos SL, Miller RL, Chun SJ, Norrbom M, Wozniak DF, Dawson HN, Bennett CF, Rigo F, Miller TM
Neuron 2016 Jun 1;90(5):941-7
Neuron 2016 Jun 1;90(5):941-7
Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease.
Velazquez R, Shaw DM, Caccamo A, Oddo S
Molecular neurodegeneration 2016 Jul 13;11(1):52
Molecular neurodegeneration 2016 Jul 13;11(1):52
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Müller-Schiffmann A, Herring A, Abdel-Hafiz L, Chepkova AN, Schäble S, Wedel D, Horn AH, Sticht H, de Souza Silva MA, Gottmann K, Sergeeva OA, Huston JP, Keyvani K, Korth C
Brain : a journal of neurology 2016 Feb;139(Pt 2):509-25
Brain : a journal of neurology 2016 Feb;139(Pt 2):509-25
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Platt TL, Beckett TL, Kohler K, Niedowicz DM, Murphy MP
Neuroscience 2016 Feb 19;315:162-74
Neuroscience 2016 Feb 19;315:162-74
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, Hansen DV, Atwal J, Lu Y, Bumbaca D, Pfeifer A, Watts RJ, Muhs A, Scearce-Levie K, Ayalon G
Cell reports 2016 Aug 9;16(6):1690-1700
Cell reports 2016 Aug 9;16(6):1690-1700
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J
Acta neuropathologica communications 2016 Aug 26;4(1):91
Acta neuropathologica communications 2016 Aug 26;4(1):91
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition.
Kim H, Lee KS, Kim AK, Choi M, Choi K, Kang M, Chi SW, Lee MS, Lee JS, Lee SY, Song WJ, Yu K, Cho S
Disease models & mechanisms 2016 Aug 1;9(8):839-48
Disease models & mechanisms 2016 Aug 1;9(8):839-48
Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.
Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L
EMBO reports 2016 Apr;17(4):530-51
EMBO reports 2016 Apr;17(4):530-51
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Van der Jeugd A, Vermaercke B, Halliday GM, Staufenbiel M, Götz J
Neurobiology of learning and memory 2016 Apr;130:34-43
Neurobiology of learning and memory 2016 Apr;130:34-43
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL, Gan L
Neuron 2016 Apr 20;90(2):245-60
Neuron 2016 Apr 20;90(2):245-60
The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.
Brelstaff J, Ossola B, Neher JJ, Klingstedt T, Nilsson KP, Goedert M, Spillantini MG, Tolkovsky AM
Frontiers in neuroscience 2015;9:184
Frontiers in neuroscience 2015;9:184
Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.
Saidi LJ, Polydoro M, Kay KR, Sanchez L, Mandelkow EM, Hyman BT, Spires-Jones TL
Journal of Alzheimer's disease : JAD 2015;44(3):937-47
Journal of Alzheimer's disease : JAD 2015;44(3):937-47
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Dunn HC, Ager RR, Baglietto-Vargas D, Cheng D, Kitazawa M, Cribbs DH, Medeiros R
Journal of Alzheimer's disease : JAD 2015;43(3):893-903
Journal of Alzheimer's disease : JAD 2015;43(3):893-903
Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain.
Day RJ, Mason MJ, Thomas C, Poon WW, Rohn TT
PloS one 2015;10(7):e0132637
PloS one 2015;10(7):e0132637
Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.
Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, Barrezueta N, Polson C, Wes P, Rangan VS, Cacace A, Albright CF, Meredith J Jr, Trojanowski JQ, Lee VM, Brunden KR, Ahlijanian M
PloS one 2015;10(5):e0125614
PloS one 2015;10(5):e0125614
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L
Nature medicine 2015 Oct;21(10):1154-62
Nature medicine 2015 Oct;21(10):1154-62
Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.
Usenovic M, Niroomand S, Drolet RE, Yao L, Gaspar RC, Hatcher NG, Schachter J, Renger JJ, Parmentier-Batteur S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Oct 21;35(42):14234-50
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Oct 21;35(42):14234-50
Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.
Caccamo A, Branca C, Talboom JS, Shaw DM, Turner D, Ma L, Messina A, Huang Z, Wu J, Oddo S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Oct 14;35(41):14042-56
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Oct 14;35(41):14042-56
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT
Nature communications 2015 Oct 13;6:8490
Nature communications 2015 Oct 13;6:8490
Depletion of microglia and inhibition of exosome synthesis halt tau propagation.
Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T
Nature neuroscience 2015 Nov;18(11):1584-93
Nature neuroscience 2015 Nov;18(11):1584-93
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M
Acta neuropathologica 2015 Nov;130(5):619-31
Acta neuropathologica 2015 Nov;130(5):619-31
Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent.
Orr ME, Garbarino VR, Salinas A, Buffenstein R
Neurobiology of aging 2015 Mar;36(3):1496-504
Neurobiology of aging 2015 Mar;36(3):1496-504
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Song L, Lu SX, Ouyang X, Melchor J, Lee J, Terracina G, Wang X, Hyde L, Hess JF, Parker EM, Zhang L
Molecular neurodegeneration 2015 Mar 26;10:14
Molecular neurodegeneration 2015 Mar 26;10:14
Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Mikhail F, Calingasan N, Parolari L, Subramanian A, Yang L, Flint Beal M
Human molecular genetics 2015 Jun 15;24(12):3545-56
Human molecular genetics 2015 Jun 15;24(12):3545-56
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
Falcon B, Cavallini A, Angers R, Glover S, Murray TK, Barnham L, Jackson S, O'Neill MJ, Isaacs AM, Hutton ML, Szekeres PG, Goedert M, Bose S
The Journal of biological chemistry 2015 Jan 9;290(2):1049-65
The Journal of biological chemistry 2015 Jan 9;290(2):1049-65
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Lauretti E, Di Meco A, Chu J, Praticò D
Neurobiology of aging 2015 Feb;36(2):812-20
Neurobiology of aging 2015 Feb;36(2):812-20
Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger JJ, Zerbinatti C
PloS one 2014;9(7):e103187
PloS one 2014;9(7):e103187
Piericidin A aggravates Tau pathology in P301S transgenic mice.
Höllerhage M, Deck R, De Andrade A, Respondek G, Xu H, Rösler TW, Salama M, Carlsson T, Yamada ES, Gad El Hak SA, Goedert M, Oertel WH, Höglinger GU
PloS one 2014;9(12):e113557
PloS one 2014;9(12):e113557
Premature lethality, hyperactivity, and aberrant phosphorylation in transgenic mice expressing a constitutively active form of Fyn.
Xia D, Götz J
Frontiers in molecular neuroscience 2014;7:40
Frontiers in molecular neuroscience 2014;7:40
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Xu H, Rösler TW, Carlsson T, de Andrade A, Fiala O, Hollerhage M, Oertel WH, Goedert M, Aigner A, Höglinger GU
Current gene therapy 2014;14(5):343-51
Current gene therapy 2014;14(5):343-51
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Xu H, Rösler TW, Carlsson T, de Andrade A, Fiala O, Hollerhage M, Oertel WH, Goedert M, Aigner A, Höglinger GU
Current gene therapy 2014;14(5):343-51
Current gene therapy 2014;14(5):343-51
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.
Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S
Molecular neurodegeneration 2014 Nov 23;9:52
Molecular neurodegeneration 2014 Nov 23;9:52
Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.
Rice RA, Berchtold NC, Cotman CW, Green KN
Neurobiology of aging 2014 May;35(5):1002-11
Neurobiology of aging 2014 May;35(5):1002-11
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
Shilling D, Müller M, Takano H, Mak DO, Abel T, Coulter DA, Foskett JK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 14;34(20):6910-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 14;34(20):6910-23
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Yamada ES, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, Rastetter A, Tarze A, Friguet B, Salama M, Champy P, Oertel WH, Höglinger GU
Experimental neurology 2014 Mar;253:113-25
Experimental neurology 2014 Mar;253:113-25
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Li JG, Chu J, Barrero C, Merali S, Praticò D
Annals of neurology 2014 Jun;75(6):851-63
Annals of neurology 2014 Jun;75(6):851-63
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Orr ME, Salinas A, Buffenstein R, Oddo S
Neurobiology of aging 2014 Jun;35(6):1233-42
Neurobiology of aging 2014 Jun;35(6):1233-42
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F
The European journal of neuroscience 2014 Jul;40(2):2442-53
The European journal of neuroscience 2014 Jul;40(2):2442-53
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM
Neurobiology of disease 2014 Feb;62:407-15
Neurobiology of disease 2014 Feb;62:407-15
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM
The American journal of pathology 2014 Feb;184(2):520-9
The American journal of pathology 2014 Feb;184(2):520-9
Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease.
Choi BR, Cho WH, Kim J, Lee HJ, Chung C, Jeon WK, Han JS
Experimental & molecular medicine 2014 Feb 7;46(2):e75
Experimental & molecular medicine 2014 Feb 7;46(2):e75
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
Di Meco A, Joshi YB, Praticò D
Neurobiology of aging 2014 Aug;35(8):1813-20
Neurobiology of aging 2014 Aug;35(8):1813-20
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.
Fernández-Nogales M, Cabrera JR, Santos-Galindo M, Hoozemans JJ, Ferrer I, Rozemuller AJ, Hernández F, Avila J, Lucas JJ
Nature medicine 2014 Aug;20(8):881-5
Nature medicine 2014 Aug;20(8):881-5
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H
Neuropharmacology 2014 Apr;79:307-13
Neuropharmacology 2014 Apr;79:307-13
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
Chabrier MA, Cheng D, Castello NA, Green KN, LaFerla FM
Neurobiology of disease 2014 Apr;64:107-17
Neurobiology of disease 2014 Apr;64:107-17
Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy.
Theunis C, Crespo-Biel N, Gafner V, Pihlgren M, López-Deber MP, Reis P, Hickman DT, Adolfsson O, Chuard N, Ndao DM, Borghgraef P, Devijver H, Van Leuven F, Pfeifer A, Muhs A
PloS one 2013;8(8):e72301
PloS one 2013;8(8):e72301
Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.
Maurin H, Seymour CM, Lechat B, Borghgraef P, Devijver H, Jaworski T, Schmidt MV, Kuegler S, Van Leuven F
PloS one 2013;8(5):e63589
PloS one 2013;8(5):e63589
Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.
Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG
PloS one 2013;8(3):e59735
PloS one 2013;8(3):e59735
PINCH in the cellular stress response to tau-hyperphosphorylation.
Ozdemir AY, Rom I, Kovalevich J, Yen W, Adiga R, Dave RS, Langford D
PloS one 2013;8(3):e58232
PloS one 2013;8(3):e58232
Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.
Borghgraef P, Menuet C, Theunis C, Louis JV, Devijver H, Maurin H, Smet-Nocca C, Lippens G, Hilaire G, Gijsen H, Moechars D, Van Leuven F
PloS one 2013;8(12):e84442
PloS one 2013;8(12):e84442
Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease.
Meredith JE Jr, Sankaranarayanan S, Guss V, Lanzetti AJ, Berisha F, Neely RJ, Slemmon JR, Portelius E, Zetterberg H, Blennow K, Soares H, Ahlijanian M, Albright CF
PloS one 2013;8(10):e76523
PloS one 2013;8(10):e76523
Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations.
Roher AE, Maarouf CL, Malek-Ahmadi M, Wilson J, Kokjohn TA, Daugs ID, Whiteside CM, Kalback WM, Macias MP, Jacobson SA, Sabbagh MN, Ghetti B, Beach TG
American journal of neurodegenerative disease 2013;2(3):187-207
American journal of neurodegenerative disease 2013;2(3):187-207
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B
Neuro-degenerative diseases 2013;11(4):194-205
Neuro-degenerative diseases 2013;11(4):194-205
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN
Biological psychiatry 2013 Sep 1;74(5):357-66
Biological psychiatry 2013 Sep 1;74(5):357-66
Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.
Pristerà A, Saraulli D, Farioli-Vecchioli S, Strimpakos G, Costanzi M, di Certo MG, Cannas S, Ciotti MT, Tirone F, Mattei E, Cestari V, Canu N
Neurobiology of aging 2013 Nov;34(11):2551-63
Neurobiology of aging 2013 Nov;34(11):2551-63
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.
Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, Neny M, Beher D, Carlson G, O'Moore J, Shearman M, Hering H
FEBS letters 2013 Nov 15;587(22):3722-8
FEBS letters 2013 Nov 15;587(22):3722-8
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Köhler C, Dinekov M, Götz J
Neurobiology of aging 2013 May;34(5):1369-79
Neurobiology of aging 2013 May;34(5):1369-79
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Nash KR, Lee DC, Hunt JB Jr, Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D
Neurobiology of aging 2013 Jun;34(6):1540-8
Neurobiology of aging 2013 Jun;34(6):1540-8
Neurochemical profile of dementia pugilistica.
Kokjohn TA, Maarouf CL, Daugs ID, Hunter JM, Whiteside CM, Malek-Ahmadi M, Rodriguez E, Kalback W, Jacobson SA, Sabbagh MN, Beach TG, Roher AE
Journal of neurotrauma 2013 Jun 1;30(11):981-97
Journal of neurotrauma 2013 Jun 1;30(11):981-97
Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.
Lund H, Cowburn RF, Gustafsson E, Strömberg K, Svensson A, Dahllund L, Malinowsky D, Sunnemark D
Brain pathology (Zurich, Switzerland) 2013 Jul;23(4):378-89
Brain pathology (Zurich, Switzerland) 2013 Jul;23(4):378-89
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Morcinek K, Köhler C, Götz J, Schröder H
Brain research 2013 Feb 25;1497:73-84
Brain research 2013 Feb 25;1497:73-84
Synaptic alterations in the rTg4510 mouse model of tauopathy.
Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL
The Journal of comparative neurology 2013 Apr 15;521(6):1334-53
The Journal of comparative neurology 2013 Apr 15;521(6):1334-53
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L
PloS one 2012;7(9):e45881
PloS one 2012;7(9):e45881
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, Maruyama H, Ichikawa T, Obata F
PloS one 2012;7(1):e30834
PloS one 2012;7(1):e30834
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S.
Deramecourt V, Lebert F, Maurage CA, Fernandez-Gomez FJ, Dujardin S, Colin M, Sergeant N, Buée-Scherrer V, Clot F, Ber IL, Brice A, Pasquier F, Buée L
Journal of Alzheimer's disease : JAD 2012;31(4):741-9
Journal of Alzheimer's disease : JAD 2012;31(4):741-9
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Clausen A, Xu X, Bi X, Baudry M
Journal of Alzheimer's disease : JAD 2012;30(1):183-208
Journal of Alzheimer's disease : JAD 2012;30(1):183-208
Hippocampal BDNF expression in a tau transgenic mouse model.
Burnouf S, Belarbi K, Troquier L, Derisbourg M, Demeyer D, Leboucher A, Laurent C, Hamdane M, Buee L, Blum D
Current Alzheimer research 2012 May;9(4):406-10
Current Alzheimer research 2012 May;9(4):406-10
Hippocampal BDNF expression in a tau transgenic mouse model.
Burnouf S, Belarbi K, Troquier L, Derisbourg M, Demeyer D, Leboucher A, Laurent C, Hamdane M, Buee L, Blum D
Current Alzheimer research 2012 May;9(4):406-10
Current Alzheimer research 2012 May;9(4):406-10
Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice.
Silveyra MX, García-Ayllón MS, de Barreda EG, Small DH, Martínez S, Avila J, Sáez-Valero J
Neurobiology of aging 2012 Mar;33(3):624.e23-34
Neurobiology of aging 2012 Mar;33(3):624.e23-34
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.
Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Brunden KR
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 14;32(11):3601-11
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 14;32(11):3601-11
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Fine JM, Baillargeon AM, Renner DB, Hoerster NS, Tokarev J, Colton S, Pelleg A, Andrews A, Sparley KA, Krogh KM, Frey WH, Hanson LR
Experimental brain research 2012 Jun;219(3):381-90
Experimental brain research 2012 Jun;219(3):381-90
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T
The Journal of biological chemistry 2012 Jun 1;287(23):19715-24
The Journal of biological chemistry 2012 Jun 1;287(23):19715-24
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Ksiezak-Reding H, Ho L, Santa-Maria I, Diaz-Ruiz C, Wang J, Pasinetti GM
Neurobiology of aging 2012 Jul;33(7):1427-39
Neurobiology of aging 2012 Jul;33(7):1427-39
Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Khandelwal PJ, Dumanis SB, Herman AM, Rebeck GW, Moussa CE
Molecular and cellular neurosciences 2012 Jan;49(1):44-53
Molecular and cellular neurosciences 2012 Jan;49(1):44-53
Propagation of tau pathology in a model of early Alzheimer's disease.
de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT
Neuron 2012 Feb 23;73(4):685-97
Neuron 2012 Feb 23;73(4):685-97
Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells.
Takahashi M, Chin Y, Nonaka T, Hasegawa M, Watanabe N, Arai T
Neuroscience letters 2012 Feb 21;510(1):48-52
Neuroscience letters 2012 Feb 21;510(1):48-52
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klärner FG, Schrader T, Frautschy SA, Grassi C, Bitan G
Brain : a journal of neurology 2012 Dec;135(Pt 12):3735-48
Brain : a journal of neurology 2012 Dec;135(Pt 12):3735-48
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM
The American journal of pathology 2012 Aug;181(2):616-25
The American journal of pathology 2012 Aug;181(2):616-25
Frontal cortex neuropathology in dementia pugilistica.
Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E
Journal of neurotrauma 2012 Apr 10;29(6):1054-70
Journal of neurotrauma 2012 Apr 10;29(6):1054-70
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
Maarouf CL, Daugs ID, Kokjohn TA, Walker DG, Hunter JM, Kruchowsky JC, Woltjer R, Kaye J, Castaño EM, Sabbagh MN, Beach TG, Roher AE
PloS one 2011;6(11):e27291
PloS one 2011;6(11):e27291
Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.
Barten DM, Cadelina GW, Hoque N, DeCarr LB, Guss VL, Yang L, Sankaranarayanan S, Wes PD, Flynn ME, Meredith JE, Ahlijanian MK, Albright CF
Journal of Alzheimer's disease : JAD 2011;24 Suppl 2:127-41
Journal of Alzheimer's disease : JAD 2011;24 Suppl 2:127-41
Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model.
Tang JX, Mardini F, Caltagarone BM, Garrity ST, Li RQ, Bianchi SL, Gomes O, Laferla FM, Eckenhoff RG, Eckenhoff MF
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011 Sep;7(5):521-531.e1
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011 Sep;7(5):521-531.e1
Morin attenuates tau hyperphosphorylation by inhibiting GSK3β.
Gong EJ, Park HR, Kim ME, Piao S, Lee E, Jo DG, Chung HY, Ha NC, Mattson MP, Lee J
Neurobiology of disease 2011 Nov;44(2):223-30
Neurobiology of disease 2011 Nov;44(2):223-30
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean ME, Humez S, Balschun D, Blum D, Buée L, D'Hooge R
Neurobiology of learning and memory 2011 Mar;95(3):296-304
Neurobiology of learning and memory 2011 Mar;95(3):296-304
Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity.
Medina DX, Caccamo A, Oddo S
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):140-9
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):140-9
6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors.
Coffman K, Brodney M, Cook J, Lanyon L, Pandit J, Sakya S, Schachter J, Tseng-Lovering E, Wessel M
Bioorganic & medicinal chemistry letters 2011 Mar 1;21(5):1429-33
Bioorganic & medicinal chemistry letters 2011 Mar 1;21(5):1429-33
Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ
Journal of neuroscience research 2011 Jun;89(6):822-32
Journal of neuroscience research 2011 Jun;89(6):822-32
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Clos AL, Jackson GR, Kayed R
Molecular neurodegeneration 2011 Jun 6;6:39
Molecular neurodegeneration 2011 Jun 6;6:39
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
Tran HT, LaFerla FM, Holtzman DM, Brody DL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
Nuclear tau, a key player in neuronal DNA protection.
Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, Mansuroglu Z, Marzin D, Sergeant N, Humez S, Colin M, Bonnefoy E, Buée L, Galas MC
The Journal of biological chemistry 2011 Feb 11;286(6):4566-75
The Journal of biological chemistry 2011 Feb 11;286(6):4566-75
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.
Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM
The American journal of pathology 2011 Aug;179(2):980-91
The American journal of pathology 2011 Aug;179(2):980-91
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Kovacs GG, Molnár K, László L, Ströbel T, Botond G, Hönigschnabl S, Reiner-Concin A, Palkovits M, Fischer P, Budka H
Acta neuropathologica 2011 Aug;122(2):205-22
Acta neuropathologica 2011 Aug;122(2):205-22
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.
Li Y, Duffy KB, Ottinger MA, Ray B, Bailey JA, Holloway HW, Tweedie D, Perry T, Mattson MP, Kapogiannis D, Sambamurti K, Lahiri DK, Greig NH
Journal of Alzheimer's disease : JAD 2010;19(4):1205-19
Journal of Alzheimer's disease : JAD 2010;19(4):1205-19
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.
Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJ
The European journal of neuroscience 2010 Sep;32(6):905-20
The European journal of neuroscience 2010 Sep;32(6):905-20
Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.
Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ
The American journal of pathology 2010 Sep;177(3):1422-35
The American journal of pathology 2010 Sep;177(3):1422-35
Spatially pathogenic forms of tau detected in Alzheimer's disease brain tissue by fluorescence lifetime-based Förster resonance energy transfer.
Larionov S, Wielgat P, Wang Y, Thal DR, Neumann H
Journal of neuroscience methods 2010 Sep 30;192(1):127-37
Journal of neuroscience methods 2010 Sep 30;192(1):127-37
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Bittner T, Fuhrmann M, Burgold S, Ochs SM, Hoffmann N, Mitteregger G, Kretzschmar H, LaFerla FM, Herms J
PloS one 2010 Nov 16;5(11):e15477
PloS one 2010 Nov 16;5(11):e15477
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins.
Krupka N, Strappe P, Götz J, Ittner LM
Plasmid 2010 May;63(3):155-60
Plasmid 2010 May;63(3):155-60
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Giménez-Llort L, Botana LM
Cellular and molecular neurobiology 2010 May;30(4):577-90
Cellular and molecular neurobiology 2010 May;30(4):577-90
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM
The American journal of pathology 2010 Feb;176(2):870-80
The American journal of pathology 2010 Feb;176(2):870-80
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Götz J
Cell 2010 Aug 6;142(3):387-97
Cell 2010 Aug 6;142(3):387-97
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
Köhler C, Bista P, Götz J, Schröder H
Brain research 2010 Aug 6;1347:111-24
Brain research 2010 Aug 6;1347:111-24
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Götz J, Ittner LM
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 3;107(31):13888-93
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 3;107(31):13888-93
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.
Caccamo A, Majumder S, Richardson A, Strong R, Oddo S
The Journal of biological chemistry 2010 Apr 23;285(17):13107-20
The Journal of biological chemistry 2010 Apr 23;285(17):13107-20
Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.
Campos-Peña V, Tapia-Ramírez J, Sánchez-Torres C, Meraz-Rios MA
Journal of Alzheimer's disease : JAD 2009;18(4):919-33
Journal of Alzheimer's disease : JAD 2009;18(4):919-33
Transmission and spreading of tauopathy in transgenic mouse brain.
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M
Nature cell biology 2009 Jul;11(7):909-13
Nature cell biology 2009 Jul;11(7):909-13
A cellular model to monitor proteasome dysfunction by alpha-synuclein.
Nonaka T, Hasegawa M
Biochemistry 2009 Aug 25;48(33):8014-22
Biochemistry 2009 Aug 25;48(33):8014-22
Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations.
Maarouf CL, Daugs ID, Spina S, Vidal R, Kokjohn TA, Patton RL, Kalback WM, Luehrs DC, Walker DG, Castaño EM, Beach TG, Ghetti B, Roher AE
Molecular neurodegeneration 2008 Nov 20;3:20
Molecular neurodegeneration 2008 Nov 20;3:20
ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation.
Resende R, Ferreiro E, Pereira C, Oliveira CR
Journal of neuroscience research 2008 Jul;86(9):2091-9
Journal of neuroscience research 2008 Jul;86(9):2091-9
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G
Proceedings of the National Academy of Sciences of the United States of America 2007 May 29;104(22):9511-6
Proceedings of the National Academy of Sciences of the United States of America 2007 May 29;104(22):9511-6
Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification.
Yamamori H, Khatoon S, Grundke-Iqbal I, Blennow K, Ewers M, Hampel H, Iqbal K
Neuroscience letters 2007 May 17;418(2):186-9
Neuroscience letters 2007 May 17;418(2):186-9
Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease.
Tremblay C, Pilote M, Phivilay A, Emond V, Bennett DA, Calon F
Journal of Alzheimer's disease : JAD 2007 Dec;12(4):377-90
Journal of Alzheimer's disease : JAD 2007 Dec;12(4):377-90
Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease.
Tremblay C, Pilote M, Phivilay A, Emond V, Bennett DA, Calon F
Journal of Alzheimer's disease : JAD 2007 Dec;12(4):377-90
Journal of Alzheimer's disease : JAD 2007 Dec;12(4):377-90
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM
Journal of neurochemistry 2007 Aug;102(4):1053-63
Journal of neurochemistry 2007 Aug;102(4):1053-63
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- Fig. 7. Oral administration of CX-4945 suppresses Tau phosphorylation in DYRK1A-overexpressing mice. (A) Hippocampuses from normal and DYRK1A-overexpressing C57BL/6 mice ( n =5 for each) were harvested, and the phosphorylation of Tau was analyzed by western blotting with anti-phosphorylated-Tau (at residue T212; p-Tau) and anti-Tau antibodies. alpha-Tubulin was also analyzed as a loading control. (B) The phosphorylated and total Tau proteins in panel A were quantified, and the mean amount of each protein was calculated. Relative ratios of phosphorylated Tau to total Tau (pTau/Tau) were presented by setting the value from normal mice as 100%. (C) DYRK1A-overexpressing C57BL/6 mice ( n =5 for each group) were administered orally with DMSO or 75 mg/kg of body weight of CX-4945 in PBS. Thirty minutes after oral administration, mice were killed, and the hippocampus was dissected from each mouse. Total cell lysates were prepared and subjected to western blotting with the indicated antibodies. alpha-Tubulin was also analyzed as a loading control. (D) The phosphorylated and total Tau proteins in panel C were quantified, and the mean amount of each protein across the animals was calculated. Relative ratios of phosphorylated Tau to total Tau were calculated by setting the value from DYRK1A mice that had been treated with DMSO as 100%. Data are means+-s.d. (two-tailed Student's t -test).
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- Fig. 7. Oral administration of CX-4945 suppresses Tau phosphorylation in DYRK1A-overexpressing mice. (A) Hippocampuses from normal and DYRK1A-overexpressing C57BL/6 mice ( n =5 for each) were harvested, and the phosphorylation of Tau was analyzed by western blotting with anti-phosphorylated-Tau (at residue T212; p-Tau) and anti-Tau antibodies. alpha-Tubulin was also analyzed as a loading control. (B) The phosphorylated and total Tau proteins in panel A were quantified, and the mean amount of each protein was calculated. Relative ratios of phosphorylated Tau to total Tau (pTau/Tau) were presented by setting the value from normal mice as 100%. (C) DYRK1A-overexpressing C57BL/6 mice ( n =5 for each group) were administered orally with DMSO or 75 mg/kg of body weight of CX-4945 in PBS. Thirty minutes after oral administration, mice were killed, and the hippocampus was dissected from each mouse. Total cell lysates were prepared and subjected to western blotting with the indicated antibodies. alpha-Tubulin was also analyzed as a loading control. (D) The phosphorylated and total Tau proteins in panel C were quantified, and the mean amount of each protein across the animals was calculated. Relative ratios of phosphorylated Tau to total Tau were calculated by setting the value from DYRK1A mice that had been treated with DMSO as 100%. Data are means+-s.d. (two-tailed Student's t -test).
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- Figure 5 Higher level of total tau, phospho-tau and cleaved tau in P301S mice receiving an Abeta 1-42 injection into the entorhinal cortex as compared with Abeta 1-40 injection. 8 month old P301S mice were injected with Abeta1-40 into the left entorhinal cortex and Abeta1-42 into the right entorhinal cortex. 18 days after injection, the brain extracts were analyzed by western blot. A) Representative images of western blots of soluble tau (S1 fraction) detected with anti-tau antibodies and normalized to actin. B) Quantification of western blots in (A) . C) Representative images of western blots of insoluble tau (P1 fraction) detected with anti-tau antibodies. Both S1 brain fraction and P1 brain fraction show a significant increase in HT7, PHF-1 and pS262 signal in entorhinal cortex injected with Abeta1-42 compared with Abeta1-40 injected entorhinal cortex. Also more cleaved tau (Tau421) was detected in the S1 fraction from the Abeta1-42 injected brain. D) Quantification of western blots in (C) . Histographs show mean +/- standard error, n =3. *p
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- Figure 7 Abeta 1-42 promotes tau phosphorylation, cleavage and aggregation while Abeta 1-40 does not. 8 month old P301S mice (1N4R form with Prion promoter) were injected with saline into the left entorhinal cortex and Abeta1-42 (2ug) into the right entorhinal cortex or saline into the left entorhinal cortex and Abeta1-40 (2ug) into the right entorhinal cortex. 18 days after injection, the brain extracts were analyzed by western blot. A) Representative images of western blots of soluble tau (S1 fraction) detected with anti-tau antibodies and normalized to actin. B) Quantification of western blots in (A) . C) Representative images of western blots of insoluble tau (P1 fraction), detected with anti-tau antibodies. D) Quantification of western blots in (C) Abeta1-42 injection significantly induced tau phosphorylation (PHF-1 and pS262 epitope) in the S1 and P1 brain fractions. 3-fold increase in Tau421 was found in the soluble fraction (A and B) . Significant decrease in pS262 immunoreactivity was observed in S1 fraction from Abeta1-40 injected brain areas compared to control side. Histographs show mean +/- standard error, n =3. *p
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- Figure 2 Diet-induced HHcy in brain affects tau phosphorylation and pathology A. Brain cortex homogenates from h-tau mice receiving the low folate and B vitamins diet (DIET) or chow diet controls (CTR) from 4 to 12 months of age were assayed by HPLC for levels of Hcy, SAM, SAH, and the ratio SAM/SAH calculated (*p
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- Fig 1 Immunodepletion with p-Tau antibodies reduces tau pathology in a primary neuronal model of tau aggregation. A. Kinetics of association and dissociation of PHF6 antibody and PHF13 antibody. The table summarizes the calculated association rates, dissociation rates, and K D values for PHF6 and PHF13. The vertical dotted lines demarcate, from left to right--peptide loading, wash/equilibration, antibody association and antibody dissociation. B. Representative images from Triton-insoluble MC1 staining of primary neurons that received no PFF treatment (- PFF), treatment with 100 nM K18PL PFF (+ PFF), rTg4510 brain extract (Tg4510) or tTA brain extract (tTA). C. Change in Triton-insoluble MC1 staining intensity in primary neurons treated as in B, relative to untreated cultures (n = 6 wells/condition; ANOVA with Dunnett's test vs. no treatment). D. Immunodepletion of rTg4510 extracts with PHF6 or PHF13 led to significant declines in Triton-insoluble MC1staining (Red bar) in neurons relative to control antibody (ANOVA with Dunnett's test vs. Control IgG). Also displayed are total tau (black bar) and p-tau levels (blue bar) measured by ELISA after immunodepletion (*p
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- Figure 3 A beta1-42 promotes phosphorylation, cleavage and aggregation of tau by increasing GSK3beta activity and by activating pro-caspase3. Sequential extraction was performed on Tau441-YFP-transfected cells treated with transfection reagent alone (control), 200 nM Abeta1-40 or Abeta1-42 for 24 h. Triton fraction was obtained by extracting intracellular tau with 1% Triton. Triton-insoluble fraction was then solubilized with 1% SDS to get SDS fraction. A) Triton fraction was electrophoresed and immunoblotted for total tau (HT7), p-tau(Ser 396/404 ) (PHF-1), p-tau(Thr 262 ) (pS262), Tau421(tau-C3) and beta-actin. beta-Actin was measured from the same blots to ensure that equal protein was present in every lane. Abeta1-42 significantly induced p-tau at Thr 231 and increased levels of Tau421 were observed in Abeta1-42 treated cells, while no change occurred in Abeta1-40 treated cells when compared to cells without treatment. B) Quantification of western blots in (A) . C) Representative images of western blots for SDS fraction with HT7, PHF-1 and pS262. All 3 forms of tau increased in Abeta1-42 treated cells. No change in tau level was found in Abeta1-40 treated cells. There was no detectable signal for tau-C3 in SDS fraction. D) Quantification of western blots in (C) . E) Triton fraction was also blotted with anti-GSK3beta antibody, anti-p-GSK3beta (Y216) and anti-caspase-3 antibody. Abeta1-42 treatment resulted in an increase in phosphorylation of GSK3beta, which represents hi
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- Fig. 9 An electrochemiluminescence ELISA detects tau PTMs in hTg-Tau mouse brain lysates. Sandwich ELISA assays using biotinylated antibodies for capture and sulfo-tagged Tau-12 antibody for detection demonstrate strong and specific signals for all antibodies in the panel. a Tau-12 cannot be used as capture and detection antibody at the same time, while all other total tau and tau isoform-specific antibodies in the panel are suitable to detect tau in hTg-Tau brain lysate. b All non-phospho-PTM modifications in the panel can be detected in hTg-Tau brain lysate. c All phospho-specific tau antibodies in the panel give signal from hTg-Tau brain lysate
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- Figure 2 Lack of PBS-soluble phosphorylated HMW tau species is associated with low tau uptake in primary neurons. ( a , top) Uptake of human tau from brain extracts from rTg4510 and rTg21221 mice by primary neurons (PBS-3,000 g , 500 ng ml -1 human tau). Neurons were immunostained with human tau-specific antibody (green) and total (human and mouse) tau antibody (red). ( a , bottom) Tau uptake assay in HEK-tau-biosensor cells. Brain extracts (10 mug protein) were applied to the cells (lipofectamie (-)). ( n =4) Unpaired t -test. Scale bar, 50 mum. ( b ) Human tau levels in brain extracts (ELISA). ( c ) Immunoblot analysis of PBS-soluble extracts with total tau antibody (DA9). Up-shifted bands in rTg4510 brain suggest phosphorylation of tau (arrow). ( d ) Brain extracts were immunoblotted with phospho-tau specific antibodies recognizing different epitopes. Representative immunoblot and quantification of phospho-tau levels at each epitope. ( n =3-4) Unpaired t -test. ( e , f ) SEC analysis of PBS-soluble tau. ( e ) Representative graph of human tau levels (ELISA) in SEC-separated samples ( f ) Mean human tau levels of HMW (Frc. 2-4) and LMW (Frc. 13-16) SEC fractions. ( n =3-6) Unpaired t -test. ( g ) Immunoblot analysis (SDS-PAGE) of SEC-separated fractions from brain extracts (total tau, DAKO). Quantification of band density is also shown (right graphs) ( n =4). Unpaired t -test. ( h ) Dot blot analysis of PBS-soluble brain extracts with tau oligomer-specific antibody (T22), h
