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LearnMN1040
antibody from Invitrogen Antibodies
Targeting: MAPT
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [343]
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- Western blot [2]
- Other assay [5]
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- Product number
- MN1040 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Phospho-Tau (Thr231) Monoclonal Antibody (AT180)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MN1040 recognizes PHF-Tau and tangles. Cross-reacts weakly with normal Tau. Does not cross react with recombinant unphosphorylated human Tau. The epitope of this antibody is the phosphorylated Thr231 residue (numbering according to human Tau40).
- Antibody clone number
- AT180
- Concentration
- 0.2 mg/mL
Submitted references Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity.
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein.
Early alterations of neurovascular unit in the retina in mouse models of tauopathy.
Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice.
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease.
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases.
Late-in-life neurodegeneration after chronic sleep loss in young adult mice.
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury.
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
Truncation of Tau selectively facilitates its pathological activities.
SARS-CoV-2 targets neurons of 3D human brain organoids.
A novel structure associated with aging is augmented in the DPP6-KO mouse brain.
Rho-kinase ROCK inhibitors reduce oligomeric tau protein.
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies.
A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay.
Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment.
Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.
Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.
Fyn Kinase Controls Tau Aggregation In Vivo.
Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy.
Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner.
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr(348) phosphorylation.
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.
Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort.
Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain.
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion.
Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay.
Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer's Disease.
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
Phosphorylation of different tau sites during progression of Alzheimer's disease.
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
NAD(+) supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.
In Vivo Detection of Gray Matter Neuropathology in the 3xTg Mouse Model of Alzheimer's Disease with Diffusion Tensor Imaging.
Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.
Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.
Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology.
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.
Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology.
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Variable tau accumulation in murine models with abnormal prion protein deposits.
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Early neurovascular dysfunction in a transgenic rat model of Alzheimer's disease.
Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons.
Short and Long Term Behavioral and Pathological Changes in a Novel Rodent Model of Repetitive Mild Traumatic Brain Injury.
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy.
Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters.
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma.
Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.
A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions.
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Dexmedetomidine directly increases tau phosphorylation.
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation.
Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase.
The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.
Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product.
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
Piericidin A aggravates Tau pathology in P301S transgenic mice.
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
TFP5, a peptide derived from p35, a Cdk5 neuronal activator, rescues cortical neurons from glucose toxicity.
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
Visualizing the microtubule-associated protein tau in the nucleus.
Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.
Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease.
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.
Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.
Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession.
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Increased amyloid-β peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice.
Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis.
Dietary supplementation with S-adenosyl methionine delayed amyloid-β and tau pathology in 3xTg-AD mice.
Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model.
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway.
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.
First transgenic rat model developing progressive cortical neurofibrillary tangles.
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
Propagation of tau pathology in a model of early Alzheimer's disease.
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress.
Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.
Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.
Degenerating processes identified by electron microscopic immunocytochemical methods.
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
Physical exercise protects against Alzheimer's disease in 3xTg-AD mice.
Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model.
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.
Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation.
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.
Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.
Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model.
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
3R tau expression modifies behavior in transgenic mice.
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation.
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.
Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
Regulation of tau pathology by the microglial fractalkine receptor.
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction.
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease.
Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice.
A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.
Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy.
Amyloid and Tau accumulate in the brains of aged hydrocephalic rats.
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity.
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease.
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.
Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5.
Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.
Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases.
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation.
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau.
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Rapidly progressive neurodegenerative dementias.
Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease.
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Age and apoE associations with complex pathologic features in Alzheimer's disease.
Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice.
Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation.
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation.
ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation.
Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
Beta-amyloid burden is not associated with rates of brain atrophy.
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells.
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.
Argyrophilic grains: a distinct disease or an additive pathology?
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia.
Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline.
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.
Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Inflammatory changes parallel the early stages of Alzheimer disease.
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Rates of cerebral atrophy differ in different degenerative pathologies.
Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia.
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
Cognitive impairment and celiac disease.
Tau interacts with Golgi membranes and mediates their association with microtubules.
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Memory complaints are related to Alzheimer disease pathology in older persons.
Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.
Neuropathologic features of amnestic mild cognitive impairment.
Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations.
Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension.
Neuropathology in the S305S tau gene mutation.
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment.
The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease.
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits.
High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus.
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.
Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation.
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates.
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.
Antemortem diagnosis of frontotemporal lobar degeneration.
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease.
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Neuropathology of cognitively normal elderly.
Neuropathology of cognitively normal elderly.
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments.
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes.
Binder J, Ursu O, Bologa C, Jiang S, Maphis N, Dadras S, Chisholm D, Weick J, Myers O, Kumar P, Yang JJ, Bhaskar K, Oprea TI
Communications biology 2022 Feb 11;5(1):125
Communications biology 2022 Feb 11;5(1):125
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Stojakovic A, Chang SY, Nesbitt J, Pichurin NP, Ostroot MA, Aikawa T, Kanekiyo T, Trushina E
Journal of Alzheimer's disease : JAD 2021;79(1):335-353
Journal of Alzheimer's disease : JAD 2021;79(1):335-353
Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Jiang S, Maphis NM, Binder J, Chisholm D, Weston L, Duran W, Peterson C, Zimmerman A, Mandell MA, Jett SD, Bigio E, Geula C, Mellios N, Weick JP, Rosenberg GA, Latz E, Heneka MT, Bhaskar K
Cell reports 2021 Sep 21;36(12):109720
Cell reports 2021 Sep 21;36(12):109720
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
Nies SH, Takahashi H, Herber CS, Huttner A, Chase A, Strittmatter SM
The Journal of biological chemistry 2021 Oct;297(4):101159
The Journal of biological chemistry 2021 Oct;297(4):101159
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Chambraud B, Daguinot C, Guillemeau K, Genet M, Dounane O, Meduri G, Poüs C, Baulieu EE, Giustiniani J
Autophagy 2021 Nov;17(11):3491-3510
Autophagy 2021 Nov;17(11):3491-3510
Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein.
Lin G, Zhu F, Kanaan NM, Asano R, Shirafuji N, Sasaki H, Yamaguchi T, Enomoto S, Endo Y, Ueno A, Ikawa M, Hayashi K, Yamamura O, Yen SH, Nakamoto Y, Hamano T
International journal of molecular sciences 2021 Nov 8;22(21)
International journal of molecular sciences 2021 Nov 8;22(21)
Early alterations of neurovascular unit in the retina in mouse models of tauopathy.
Xia F, Ha Y, Shi S, Li Y, Li S, Luisi J, Kayed R, Motamedi M, Liu H, Zhang W
Acta neuropathologica communications 2021 Mar 24;9(1):51
Acta neuropathologica communications 2021 Mar 24;9(1):51
Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice.
Lin YS, Liu CK, Lee HC, Chou MC, Ke LY, Chen CH, Chen SL
Scientific reports 2021 Mar 16;11(1):6013
Scientific reports 2021 Mar 16;11(1):6013
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Kahriman A, Bouley J, Smith TW, Bosco DA, Woerman AL, Henninger N
Acta neuropathologica communications 2021 Jun 29;9(1):118
Acta neuropathologica communications 2021 Jun 29;9(1):118
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease.
McMillan PJ, Strovas TJ, Baum M, Mitchell BK, Eck RJ, Hendricks N, Wheeler JM, Latimer CS, Keene CD, Kraemer BC
Acta neuropathologica communications 2021 Jun 29;9(1):117
Acta neuropathologica communications 2021 Jun 29;9(1):117
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Subramanian M, Hyeon SJ, Das T, Suh YS, Kim YK, Lee JS, Song EJ, Ryu H, Yu K
Nature communications 2021 Jun 2;12(1):3291
Nature communications 2021 Jun 2;12(1):3291
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
Reimer L, Betzer C, Kofoed RH, Volbracht C, Fog K, Kurhade C, Nilsson E, Överby AK, Jensen PH
Brain pathology (Zurich, Switzerland) 2021 Jan;31(1):103-119
Brain pathology (Zurich, Switzerland) 2021 Jan;31(1):103-119
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases.
Ye T, Duan Y, Tsang HWS, Xu H, Chen Y, Cao H, Chen Y, Fu AKY, Ip NY
Communications biology 2021 Feb 12;4(1):195
Communications biology 2021 Feb 12;4(1):195
Late-in-life neurodegeneration after chronic sleep loss in young adult mice.
Owen JE, Zhu Y, Fenik P, Zhan G, Bell P, Liu C, Veasey S
Sleep 2021 Aug 13;44(8)
Sleep 2021 Aug 13;44(8)
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, Marcilla I, Marti-Andres G, Caballero MC, Riverol M, Tuñon MT, Fraser PE, Luquin MR
Acta neuropathologica communications 2021 Apr 8;9(1):64
Acta neuropathologica communications 2021 Apr 8;9(1):64
NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury.
Corrigan F, Cernak I, McAteer K, Hellewell SC, Rosenfeld JV, Turner RJ, Vink R
Scientific reports 2021 Apr 23;11(1):8861
Scientific reports 2021 Apr 23;11(1):8861
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
Gratuze M, Leyns CE, Sauerbeck AD, St-Pierre MK, Xiong M, Kim N, Serrano JR, Tremblay MÈ, Kummer TT, Colonna M, Ulrich JD, Holtzman DM
The Journal of clinical investigation 2020 Sep 1;130(9):4954-4968
The Journal of clinical investigation 2020 Sep 1;130(9):4954-4968
Truncation of Tau selectively facilitates its pathological activities.
Gu J, Xu W, Jin N, Li L, Zhou Y, Chu D, Gong CX, Iqbal K, Liu F
The Journal of biological chemistry 2020 Oct 2;295(40):13812-13828
The Journal of biological chemistry 2020 Oct 2;295(40):13812-13828
SARS-CoV-2 targets neurons of 3D human brain organoids.
Ramani A, Müller L, Ostermann PN, Gabriel E, Abida-Islam P, Müller-Schiffmann A, Mariappan A, Goureau O, Gruell H, Walker A, Andrée M, Hauka S, Houwaart T, Dilthey A, Wohlgemuth K, Omran H, Klein F, Wieczorek D, Adams O, Timm J, Korth C, Schaal H, Gopalakrishnan J
The EMBO journal 2020 Oct 15;39(20):e106230
The EMBO journal 2020 Oct 15;39(20):e106230
A novel structure associated with aging is augmented in the DPP6-KO mouse brain.
Lin L, Petralia RS, Lake R, Wang YX, Hoffman DA
Acta neuropathologica communications 2020 Nov 23;8(1):197
Acta neuropathologica communications 2020 Nov 23;8(1):197
Rho-kinase ROCK inhibitors reduce oligomeric tau protein.
Hamano T, Shirafuji N, Yen SH, Yoshida H, Kanaan NM, Hayashi K, Ikawa M, Yamamura O, Fujita Y, Kuriyama M, Nakamoto Y
Neurobiology of aging 2020 May;89:41-54
Neurobiology of aging 2020 May;89:41-54
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies.
Puangmalai N, Bhatt N, Montalbano M, Sengupta U, Gaikwad S, Ventura F, McAllen S, Ellsworth A, Garcia S, Kayed R
Cell death & disease 2020 May 4;11(5):314
Cell death & disease 2020 May 4;11(5):314
A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay.
Lee KS, Choi M, Kwon DW, Kim D, Choi JM, Kim AK, Ham Y, Han SB, Cho S, Cheon CK
Scientific reports 2020 Jun 17;10(1):9849
Scientific reports 2020 Jun 17;10(1):9849
Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment.
Wang Y, Liu Y, Nham A, Sherbaf A, Quach D, Yahya E, Ranburger D, Bi X, Baudry M
Science advances 2020 Jul;6(27)
Science advances 2020 Jul;6(27)
Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.
Nam E, Lee YB, Moon C, Chang KA
International journal of molecular sciences 2020 Jul 15;21(14)
International journal of molecular sciences 2020 Jul 15;21(14)
Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.
Fan Q, He W, Gayen M, Benoit MR, Luo X, Hu X, Yan R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Jan 29;40(5):1133-1144
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Jan 29;40(5):1133-1144
Fyn Kinase Controls Tau Aggregation In Vivo.
Briner A, Götz J, Polanco JC
Cell reports 2020 Aug 18;32(7):108045
Cell reports 2020 Aug 18;32(7):108045
Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy.
Maphis NM, Peabody J, Crossey E, Jiang S, Jamaleddin Ahmad FA, Alvarez M, Mansoor SK, Yaney A, Yang Y, Sillerud LO, Wilson CM, Selwyn R, Brigman JL, Cannon JL, Peabody DS, Chackerian B, Bhaskar K
NPJ vaccines 2019;4:26
NPJ vaccines 2019;4:26
Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner.
Joseph DJ, Liu C, Peng J, Liang G, Wei H
PloS one 2019;14(10):e0223509
PloS one 2019;14(10):e0223509
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr(348) phosphorylation.
Sartori M, Mendes T, Desai S, Lasorsa A, Herledan A, Malmanche N, Mäkinen P, Marttinen M, Malki I, Chapuis J, Flaig A, Vreulx AC, Ciancia M, Amouyel P, Leroux F, Déprez B, Cantrelle FX, Maréchal D, Pradier L, Hiltunen M, Landrieu I, Kilinc D, Herault Y, Laporte J, Lambert JC
Acta neuropathologica 2019 Oct;138(4):631-652
Acta neuropathologica 2019 Oct;138(4):631-652
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J, NIMA Consortium, Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH
Brain : a journal of neurology 2019 Oct 1;142(10):3243-3264
Brain : a journal of neurology 2019 Oct 1;142(10):3243-3264
A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.
Ajit D, Trzeciakiewicz H, Tseng JH, Wander CM, Chen Y, Ajit A, King DP, Cohen TJ
The Journal of biological chemistry 2019 Nov 8;294(45):16698-16711
The Journal of biological chemistry 2019 Nov 8;294(45):16698-16711
Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort.
Latimer CS, Burke BT, Liachko NF, Currey HN, Kilgore MD, Gibbons LE, Henriksen J, Darvas M, Domoto-Reilly K, Jayadev S, Grabowski TJ, Crane PK, Larson EB, Kraemer BC, Bird TD, Keene CD
Acta neuropathologica communications 2019 Jun 7;7(1):91
Acta neuropathologica communications 2019 Jun 7;7(1):91
Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Pallas-Bazarra N, Rábano A, Sah N, van Praag H, Giacomini D, Schinder AF, Ávila J, Llorens-Martín M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 17;39(29):5794-5815
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 17;39(29):5794-5815
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH
Nature medicine 2019 Jan;25(1):152-164
Nature medicine 2019 Jan;25(1):152-164
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.
Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA
Cell reports 2019 Jan 29;26(5):1112-1127.e9
Cell reports 2019 Jan 29;26(5):1112-1127.e9
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.
Mendsaikhan A, Tooyama I, Bellier JP, Serrano GE, Sue LI, Lue LF, Beach TG, Walker DG
Acta neuropathologica communications 2019 Dec 21;7(1):215
Acta neuropathologica communications 2019 Dec 21;7(1):215
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.
Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, Lee VMY, Wang LS, Keene CD, Bird T, Schellenberg GD, Kraemer B
Science translational medicine 2019 Dec 18;11(523)
Science translational medicine 2019 Dec 18;11(523)
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Jadiya P, Kolmetzky DW, Tomar D, Di Meco A, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Praticò D, Elrod JW
Nature communications 2019 Aug 29;10(1):3885
Nature communications 2019 Aug 29;10(1):3885
MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain.
Kovacs ZI, Tu TW, Sundby M, Qureshi F, Lewis BK, Jikaria N, Burks SR, Frank JA
Theranostics 2018;8(17):4837-4855
Theranostics 2018;8(17):4837-4855
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Romero-Molina C, Navarro V, Sanchez-Varo R, Jimenez S, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Muñoz-Castro C, Gutierrez A, Vitorica J, Vizuete M
Frontiers in cellular neuroscience 2018;12:421
Frontiers in cellular neuroscience 2018;12:421
Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion.
Turnbull MT, Boskovic Z, Coulson EJ
Frontiers in molecular neuroscience 2018;11:51
Frontiers in molecular neuroscience 2018;11:51
Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay.
Holzer M, Schade N, Opitz A, Hilbrich I, Stieler J, Vogel T, Neukel V, Oberstadt M, Totzke F, Schächtele C, Sippl W, Hilgeroth A
Molecules (Basel, Switzerland) 2018 Sep 12;23(9)
Molecules (Basel, Switzerland) 2018 Sep 12;23(9)
Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.
Liu D, Lu H, Stein E, Zhou Z, Yang Y, Mattson MP
Neurobiology of aging 2018 Oct;70:160-169
Neurobiology of aging 2018 Oct;70:160-169
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ
Nature 2018 Oct;562(7728):578-582
Nature 2018 Oct;562(7728):578-582
Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer's Disease.
Ahmad W
Experimental brain research 2018 Nov;236(11):2857-2866
Experimental brain research 2018 Nov;236(11):2857-2866
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.
Zhu Y, Zhan G, Fenik P, Brandes M, Bell P, Francois N, Shulman K, Veasey S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Nov 28;38(48):10255-10270
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Nov 28;38(48):10255-10270
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y
Nature medicine 2018 May;24(5):647-657
Nature medicine 2018 May;24(5):647-657
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.
Paspalas CD, Carlyle BC, Leslie S, Preuss TM, Crimins JL, Huttner AJ, van Dyck CH, Rosene DL, Nairn AC, Arnsten AFT
Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 May;14(5):680-691
Alzheimer's & dementia : the journal of the Alzheimer's Association 2018 May;14(5):680-691
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
Huang C, Irwin MG, Wong GTC, Chang RCC
Journal of neuroinflammation 2018 May 17;15(1):147
Journal of neuroinflammation 2018 May 17;15(1):147
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.
Tang M, Ji C, Pallo S, Rahman I, Johnson GVW
Neurobiology of aging 2018 Mar;63:128-139
Neurobiology of aging 2018 Mar;63:128-139
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T
EMBO molecular medicine 2018 Mar;10(3)
EMBO molecular medicine 2018 Mar;10(3)
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B
Acta neuropathologica communications 2018 Jun 29;6(1):52
Acta neuropathologica communications 2018 Jun 29;6(1):52
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
Bardai FH, Wang L, Mutreja Y, Yenjerla M, Gamblin TC, Feany MB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):108-119
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):108-119
NAD(+) supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 20;115(8):E1876-E1885
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 20;115(8):E1876-E1885
Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.
Javidnia M, Hebron ML, Xin Y, Kinney NG, Moussa CE
Journal of Alzheimer's disease : JAD 2017;60(2):461-481
Journal of Alzheimer's disease : JAD 2017;60(2):461-481
In Vivo Detection of Gray Matter Neuropathology in the 3xTg Mouse Model of Alzheimer's Disease with Diffusion Tensor Imaging.
Snow WM, Dale R, O'Brien-Moran Z, Buist R, Peirson D, Martin M, Albensi BC
Journal of Alzheimer's disease : JAD 2017;58(3):841-853
Journal of Alzheimer's disease : JAD 2017;58(3):841-853
Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.
Rueli RH, Torres DJ, Dewing AS, Kiyohara AC, Barayuga SM, Bellinger MT, Uyehara-Lock JH, White LR, Moreira PI, Berry MJ, Perry G, Bellinger FP
Journal of Alzheimer's disease : JAD 2017;55(2):749-762
Journal of Alzheimer's disease : JAD 2017;55(2):749-762
Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.
Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G
PloS one 2017;12(8):e0182844
PloS one 2017;12(8):e0182844
Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology.
Maphis NM, Jiang S, Binder J, Wright C, Gopalan B, Lamb BT, Bhaskar K
Frontiers in molecular neuroscience 2017;10:69
Frontiers in molecular neuroscience 2017;10:69
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.
Wang Y, Hall RA, Lee M, Kamgar-Parsi A, Bi X, Baudry M
Scientific reports 2017 Sep 18;7(1):11771
Scientific reports 2017 Sep 18;7(1):11771
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Lathuilière A, Valdés P, Papin S, Cacquevel M, Maclachlan C, Knott GW, Muhs A, Paganetti P, Schneider BL
Scientific reports 2017 Oct 19;7(1):13556
Scientific reports 2017 Oct 19;7(1):13556
Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.
Cisbani G, Maxan A, Kordower JH, Planel E, Freeman TB, Cicchetti F
Brain : a journal of neurology 2017 Nov 1;140(11):2982-2992
Brain : a journal of neurology 2017 Nov 1;140(11):2982-2992
Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.
Chanu SI, Sarkar S
Molecular neurobiology 2017 May;54(4):2706-2719
Molecular neurobiology 2017 May;54(4):2706-2719
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM, Alzheimer’s Disease Neuroimaging Initiative
Acta neuropathologica 2017 May;133(5):785-807
Acta neuropathologica 2017 May;133(5):785-807
A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.
Trzeciakiewicz H, Tseng JH, Wander CM, Madden V, Tripathy A, Yuan CX, Cohen TJ
Scientific reports 2017 Mar 13;7:44102
Scientific reports 2017 Mar 13;7:44102
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.
Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G
eLife 2017 Jun 26;6
eLife 2017 Jun 26;6
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology.
Kolisnyk B, Al-Onaizi M, Soreq L, Barbash S, Bekenstein U, Haberman N, Hanin G, Kish MT, Souza da Silva J, Fahnestock M, Ule J, Soreq H, Prado VF, Prado MAM
Cerebral cortex (New York, N.Y. : 1991) 2017 Jul 1;27(7):3553-3567
Cerebral cortex (New York, N.Y. : 1991) 2017 Jul 1;27(7):3553-3567
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Di Meco A, Li JG, Blass BE, Abou-Gharbia M, Lauretti E, Praticò D
Biological psychiatry 2017 Jan 15;81(2):92-100
Biological psychiatry 2017 Jan 15;81(2):92-100
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, Figueroa HY, Goldberg E, Hussaini SA, Duff KE
Neuron 2017 Feb 8;93(3):533-541.e5
Neuron 2017 Feb 8;93(3):533-541.e5
Variable tau accumulation in murine models with abnormal prion protein deposits.
Piccardo P, King D, Brown D, Barron RM
Journal of the neurological sciences 2017 Dec 15;383:142-150
Journal of the neurological sciences 2017 Dec 15;383:142-150
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.
Bodea LG, Evans HT, Van der Jeugd A, Ittner LM, Delerue F, Kril J, Halliday G, Hodges J, Kiernan MC, Götz J
Aging cell 2017 Apr;16(2):377-386
Aging cell 2017 Apr;16(2):377-386
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Li JG, Barrero C, Merali S, Praticò D
Scientific reports 2017 Apr 6;7:46002
Scientific reports 2017 Apr 6;7:46002
Early neurovascular dysfunction in a transgenic rat model of Alzheimer's disease.
Joo IL, Lai AY, Bazzigaluppi P, Koletar MM, Dorr A, Brown ME, Thomason LA, Sled JG, McLaurin J, Stefanovic B
Scientific reports 2017 Apr 12;7:46427
Scientific reports 2017 Apr 12;7:46427
Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons.
Chesser AS, Ganeshan V, Yang J, Johnson GV
Nutritional neuroscience 2016;19(1):21-31
Nutritional neuroscience 2016;19(1):21-31
Short and Long Term Behavioral and Pathological Changes in a Novel Rodent Model of Repetitive Mild Traumatic Brain Injury.
McAteer KM, Corrigan F, Thornton E, Turner RJ, Vink R
PloS one 2016;11(8):e0160220
PloS one 2016;11(8):e0160220
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
Salta E, Sierksma A, Vanden Eynden E, De Strooper B
EMBO molecular medicine 2016 Sep;8(9):1005-18
EMBO molecular medicine 2016 Sep;8(9):1005-18
Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy.
Zimova I, Brezovakova V, Hromadka T, Weisova P, Cubinkova V, Valachova B, Filipcik P, Jadhav S, Smolek T, Novak M, Zilka N
Journal of Alzheimer's disease : JAD 2016 Sep 6;54(2):831-43
Journal of Alzheimer's disease : JAD 2016 Sep 6;54(2):831-43
Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters.
Bullmann T, Seeger G, Stieler J, Hanics J, Reimann K, Kretzschmann TP, Hilbrich I, Holzer M, Alpár A, Arendt T
Hippocampus 2016 Mar;26(3):301-18
Hippocampus 2016 Mar;26(3):301-18
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Di Meco A, Joshi YB, Lauretti E, Praticò D
Molecular psychiatry 2016 Mar;21(3):403-10
Molecular psychiatry 2016 Mar;21(3):403-10
Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma.
Winston CN, Noël A, Neustadtl A, Parsadanian M, Barton DJ, Chellappa D, Wilkins TE, Alikhani AD, Zapple DN, Villapol S, Planel E, Burns MP
The American journal of pathology 2016 Mar;186(3):552-67
The American journal of pathology 2016 Mar;186(3):552-67
Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.
Ando K, Maruko-Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima KM
PLoS genetics 2016 Mar;12(3):e1005917
PLoS genetics 2016 Mar;12(3):e1005917
A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions.
Baker S, Götz J
Acta neuropathologica communications 2016 Mar 31;4:32
Acta neuropathologica communications 2016 Mar 31;4:32
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
Smolek T, Madari A, Farbakova J, Kandrac O, Jadhav S, Cente M, Brezovakova V, Novak M, Zilka N
The Journal of comparative neurology 2016 Mar 1;524(4):874-95
The Journal of comparative neurology 2016 Mar 1;524(4):874-95
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Jiang T, Zhang YD, Chen Q, Gao Q, Zhu XC, Zhou JS, Shi JQ, Lu H, Tan L, Yu JT
Neuropharmacology 2016 Jun;105:196-206
Neuropharmacology 2016 Jun;105:196-206
Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
Polanco JC, Scicluna BJ, Hill AF, Götz J
The Journal of biological chemistry 2016 Jun 10;291(24):12445-12466
The Journal of biological chemistry 2016 Jun 10;291(24):12445-12466
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Müller-Schiffmann A, Herring A, Abdel-Hafiz L, Chepkova AN, Schäble S, Wedel D, Horn AH, Sticht H, de Souza Silva MA, Gottmann K, Sergeeva OA, Huston JP, Keyvani K, Korth C
Brain : a journal of neurology 2016 Feb;139(Pt 2):509-25
Brain : a journal of neurology 2016 Feb;139(Pt 2):509-25
Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.
Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DMA, Iwatsubo T, Hasegawa M
Acta neuropathologica 2016 Feb;131(2):267-280
Acta neuropathologica 2016 Feb;131(2):267-280
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Platt TL, Beckett TL, Kohler K, Niedowicz DM, Murphy MP
Neuroscience 2016 Feb 19;315:162-74
Neuroscience 2016 Feb 19;315:162-74
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.
Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 27;113(52):15120-15125
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 27;113(52):15120-15125
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J
Acta neuropathologica communications 2016 Aug 26;4(1):91
Acta neuropathologica communications 2016 Aug 26;4(1):91
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
El Khoury NB, Gratuze M, Petry F, Papon MA, Julien C, Marcouiller F, Morin F, Nicholls SB, Calon F, Hébert SS, Marette A, Planel E
Neurobiology of disease 2016 Apr;88:55-65
Neurobiology of disease 2016 Apr;88:55-65
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Van der Jeugd A, Vermaercke B, Halliday GM, Staufenbiel M, Götz J
Neurobiology of learning and memory 2016 Apr;130:34-43
Neurobiology of learning and memory 2016 Apr;130:34-43
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Piedrahita D, Castro-Alvarez JF, Boudreau RL, Villegas-Lanau A, Kosik KS, Gallego-Gomez JC, Cardona-Gómez GP
Frontiers in cellular neuroscience 2015;9:498
Frontiers in cellular neuroscience 2015;9:498
Dexmedetomidine directly increases tau phosphorylation.
Huang C, Ho YS, Ng OT, Irwin MG, Chang RC, Wong GT
Journal of Alzheimer's disease : JAD 2015;44(3):839-50
Journal of Alzheimer's disease : JAD 2015;44(3):839-50
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Dunn HC, Ager RR, Baglietto-Vargas D, Cheng D, Kitazawa M, Cribbs DH, Medeiros R
Journal of Alzheimer's disease : JAD 2015;43(3):893-903
Journal of Alzheimer's disease : JAD 2015;43(3):893-903
Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.
Kim JM, Kim SS, Lee YD
Neuroreport 2015 Sep 9;26(13):767-72
Neuroreport 2015 Sep 9;26(13):767-72
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Yamada K, Patel TK, Hochgräfe K, Mahan TE, Jiang H, Stewart FR, Mandelkow EM, Holtzman DM
Molecular neurodegeneration 2015 Oct 26;10:55
Molecular neurodegeneration 2015 Oct 26;10:55
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M
Acta neuropathologica 2015 Nov;130(5):619-31
Acta neuropathologica 2015 Nov;130(5):619-31
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
Hunt JB Jr, Nash KR, Placides D, Moran P, Selenica ML, Abuqalbeen F, Ratnasamy K, Slouha N, Rodriguez-Ospina S, Savlia M, Ranaweera Y, Reid P, Dickey CA, Uricia R, Yang CG, Sandusky LA, Gordon MN, Morgan D, Lee DC
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Nov 4;35(44):14842-60
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Nov 4;35(44):14842-60
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Sepulveda-Diaz JE, Alavi Naini SM, Huynh MB, Ouidja MO, Yanicostas C, Chantepie S, Villares J, Lamari F, Jospin E, van Kuppevelt TH, Mensah-Nyagan AG, Raisman-Vozari R, Soussi-Yanicostas N, Papy-Garcia D
Brain : a journal of neurology 2015 May;138(Pt 5):1339-54
Brain : a journal of neurology 2015 May;138(Pt 5):1339-54
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
Li R, Xu DE, Ma T
Neuroscience 2015 May 21;294:14-20
Neuroscience 2015 May 21;294:14-20
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT
The Journal of experimental medicine 2015 Mar 9;212(3):287-95
The Journal of experimental medicine 2015 Mar 9;212(3):287-95
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Song L, Lu SX, Ouyang X, Melchor J, Lee J, Terracina G, Wang X, Hyde L, Hess JF, Parker EM, Zhang L
Molecular neurodegeneration 2015 Mar 26;10:14
Molecular neurodegeneration 2015 Mar 26;10:14
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM
Annals of neurology 2015 Jun;77(6):953-71
Annals of neurology 2015 Jun;77(6):953-71
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Maphis N, Xu G, Kokiko-Cochran ON, Jiang S, Cardona A, Ransohoff RM, Lamb BT, Bhaskar K
Brain : a journal of neurology 2015 Jun;138(Pt 6):1738-55
Brain : a journal of neurology 2015 Jun;138(Pt 6):1738-55
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
Luo W, Liu W, Hu X, Hanna M, Caravaca A, Paul SM
Scientific reports 2015 Jun 9;5:11161
Scientific reports 2015 Jun 9;5:11161
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro GS, Liu D, Tian J, Baptiste BA, Cong WN, Brenerman BM, Fang E, Becker KG, Hamilton RJ, Chigurupati S, Zhang Y, Egan JM, Croteau DL, Wilson DM 3rd, Mattson MP, Bohr VA
Nucleic acids research 2015 Jan;43(2):943-59
Nucleic acids research 2015 Jan;43(2):943-59
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Ittner A, Bertz J, Suh LS, Stevens CH, Götz J, Ittner LM
Journal of neurochemistry 2015 Jan;132(1):135-45
Journal of neurochemistry 2015 Jan;132(1):135-45
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.
Mouton-Liger F, Rebillat AS, Gourmaud S, Paquet C, Leguen A, Dumurgier J, Bernadelli P, Taupin V, Pradier L, Rooney T, Hugon J
Cell death & disease 2015 Jan 15;6(1):e1594
Cell death & disease 2015 Jan 15;6(1):e1594
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Lauretti E, Di Meco A, Chu J, Praticò D
Neurobiology of aging 2015 Feb;36(2):812-20
Neurobiology of aging 2015 Feb;36(2):812-20
Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation.
Carret-Rebillat AS, Pace C, Gourmaud S, Ravasi L, Montagne-Stora S, Longueville S, Tible M, Sudol E, Chang RC, Paquet C, Mouton-Liger F, Hugon J
Scientific reports 2015 Feb 17;5:8489
Scientific reports 2015 Feb 17;5:8489
Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase.
Lauretti E, Praticò D
Aging cell 2015 Dec;14(6):1067-74
Aging cell 2015 Dec;14(6):1067-74
The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.
Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R, Kinoshita A
Molecular brain 2015 Dec 4;8(1):82
Molecular brain 2015 Dec 4;8(1):82
Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product.
Hromadkova L, Kolarova M, Jankovicova B, Bartos A, Ricny J, Bilkova Z, Ripova D
Journal of neuroimmunology 2015 Dec 15;289:121-9
Journal of neuroimmunology 2015 Dec 15;289:121-9
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.
Lee IS, Jung K, Kim IS, Lee H, Kim M, Yun S, Hwang K, Shin JE, Park KI
Molecular neurodegeneration 2015 Aug 21;10:38
Molecular neurodegeneration 2015 Aug 21;10:38
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
Petry FR, Pelletier J, Bretteville A, Morin F, Calon F, Hébert SS, Whittington RA, Planel E
PloS one 2014;9(5):e94251
PloS one 2014;9(5):e94251
Piericidin A aggravates Tau pathology in P301S transgenic mice.
Höllerhage M, Deck R, De Andrade A, Respondek G, Xu H, Rösler TW, Salama M, Carlsson T, Yamada ES, Gad El Hak SA, Goedert M, Oertel WH, Höglinger GU
PloS one 2014;9(12):e113557
PloS one 2014;9(12):e113557
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Castro-Alvarez JF, Uribe-Arias SA, Kosik KS, Cardona-Gómez GP
Frontiers in aging neuroscience 2014;6:243
Frontiers in aging neuroscience 2014;6:243
TFP5, a peptide derived from p35, a Cdk5 neuronal activator, rescues cortical neurons from glucose toxicity.
Binukumar BK, Zheng YL, Shukla V, Amin ND, Grant P, Pant HC
Journal of Alzheimer's disease : JAD 2014;39(4):899-909
Journal of Alzheimer's disease : JAD 2014;39(4):899-909
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Xu H, Rösler TW, Carlsson T, de Andrade A, Fiala O, Hollerhage M, Oertel WH, Goedert M, Aigner A, Höglinger GU
Current gene therapy 2014;14(5):343-51
Current gene therapy 2014;14(5):343-51
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Xu H, Rösler TW, Carlsson T, de Andrade A, Fiala O, Hollerhage M, Oertel WH, Goedert M, Aigner A, Höglinger GU
Current gene therapy 2014;14(5):343-51
Current gene therapy 2014;14(5):343-51
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Jiang T, Yu JT, Zhu XC, Zhang QQ, Cao L, Wang HF, Tan MS, Gao Q, Qin H, Zhang YD, Tan L
Neuropharmacology 2014 Oct;85:121-30
Neuropharmacology 2014 Oct;85:121-30
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Ohia-Nwoko O, Montazari S, Lau YS, Eriksen JL
Molecular neurodegeneration 2014 Nov 28;9:54
Molecular neurodegeneration 2014 Nov 28;9:54
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.
Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S
Molecular neurodegeneration 2014 Nov 23;9:52
Molecular neurodegeneration 2014 Nov 23;9:52
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, Fukuda Y, Nakai Y, Uchida T, Sato E, Tanemura K
FEBS letters 2014 May 29;588(11):2003-8
FEBS letters 2014 May 29;588(11):2003-8
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
Shilling D, Müller M, Takano H, Mak DO, Abel T, Coulter DA, Foskett JK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 14;34(20):6910-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 14;34(20):6910-23
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Yamada ES, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, Rastetter A, Tarze A, Friguet B, Salama M, Champy P, Oertel WH, Höglinger GU
Experimental neurology 2014 Mar;253:113-25
Experimental neurology 2014 Mar;253:113-25
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, Laferla FM
The American journal of pathology 2014 Mar;184(3):819-26
The American journal of pathology 2014 Mar;184(3):819-26
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Li JG, Chu J, Barrero C, Merali S, Praticò D
Annals of neurology 2014 Jun;75(6):851-63
Annals of neurology 2014 Jun;75(6):851-63
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F
The European journal of neuroscience 2014 Jul;40(2):2442-53
The European journal of neuroscience 2014 Jul;40(2):2442-53
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Richter M, Mewes A, Fritsch M, Krügel U, Hoffmann R, Singer D
Vaccines 2014 Jul 29;2(3):601-23
Vaccines 2014 Jul 29;2(3):601-23
Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.
Farr SA, Ripley JL, Sultana R, Zhang Z, Niehoff ML, Platt TL, Murphy MP, Morley JE, Kumar V, Butterfield DA
Free radical biology & medicine 2014 Feb;67:387-95
Free radical biology & medicine 2014 Feb;67:387-95
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM
Neurobiology of disease 2014 Feb;62:407-15
Neurobiology of disease 2014 Feb;62:407-15
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM
The American journal of pathology 2014 Feb;184(2):520-9
The American journal of pathology 2014 Feb;184(2):520-9
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.
Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Dec 3;34(49):16180-93
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Dec 3;34(49):16180-93
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
Di Meco A, Joshi YB, Praticò D
Neurobiology of aging 2014 Aug;35(8):1813-20
Neurobiology of aging 2014 Aug;35(8):1813-20
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
Chabrier MA, Cheng D, Castello NA, Green KN, LaFerla FM
Neurobiology of disease 2014 Apr;64:107-17
Neurobiology of disease 2014 Apr;64:107-17
Visualizing the microtubule-associated protein tau in the nucleus.
Lu J, Li T, He R, Bartlett PF, Götz J
Science China. Life sciences 2014 Apr;57(4):422-31
Science China. Life sciences 2014 Apr;57(4):422-31
Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.
Maurin H, Seymour CM, Lechat B, Borghgraef P, Devijver H, Jaworski T, Schmidt MV, Kuegler S, Van Leuven F
PloS one 2013;8(5):e63589
PloS one 2013;8(5):e63589
Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
Guo Q, Li H, Cole AL, Hur JY, Li Y, Zheng H
PloS one 2013;8(11):e80706
PloS one 2013;8(11):e80706
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B
Neuro-degenerative diseases 2013;11(4):194-205
Neuro-degenerative diseases 2013;11(4):194-205
Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease.
Rothman SM, Herdener N, Frankola KA, Mughal MR, Mattson MP
Brain research 2013 Sep 5;1529:200-8
Brain research 2013 Sep 5;1529:200-8
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN
Biological psychiatry 2013 Sep 1;74(5):357-66
Biological psychiatry 2013 Sep 1;74(5):357-66
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Leboucher A, Laurent C, Fernandez-Gomez FJ, Burnouf S, Troquier L, Eddarkaoui S, Demeyer D, Caillierez R, Zommer N, Vallez E, Bantubungi K, Breton C, Pigny P, Buée-Scherrer V, Staels B, Hamdane M, Tailleux A, Buée L, Blum D
Diabetes 2013 May;62(5):1681-8
Diabetes 2013 May;62(5):1681-8
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
Wu TH, Lu YN, Chuang CL, Wu CL, Chiang AS, Krantz DE, Chang HY
Acta neuropathologica 2013 May;125(5):711-25
Acta neuropathologica 2013 May;125(5):711-25
AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
Georgievska B, Sandin J, Doherty J, Mörtberg A, Neelissen J, Andersson A, Gruber S, Nilsson Y, Schött P, Arvidsson PI, Hellberg S, Osswald G, Berg S, Fälting J, Bhat RV
Journal of neurochemistry 2013 May;125(3):446-56
Journal of neurochemistry 2013 May;125(3):446-56
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.
Bomba M, Ciavardelli D, Silvestri E, Canzoniero LM, Lattanzio R, Chiappini P, Piantelli M, Di Ilio C, Consoli A, Sensi SL
Cell death & disease 2013 May 2;4(5):e612
Cell death & disease 2013 May 2;4(5):e612
Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.
Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, LaFerla FM, Olschowka JA, O'Banion MK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 13;33(11):5053-64
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 13;33(11):5053-64
Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession.
Liu D, Pitta M, Jiang H, Lee JH, Zhang G, Chen X, Kawamoto EM, Mattson MP
Neurobiology of aging 2013 Jun;34(6):1564-80
Neurobiology of aging 2013 Jun;34(6):1564-80
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Nash KR, Lee DC, Hunt JB Jr, Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D
Neurobiology of aging 2013 Jun;34(6):1540-8
Neurobiology of aging 2013 Jun;34(6):1540-8
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.
Kashiwaya Y, Bergman C, Lee JH, Wan R, King MT, Mughal MR, Okun E, Clarke K, Mattson MP, Veech RL
Neurobiology of aging 2013 Jun;34(6):1530-9
Neurobiology of aging 2013 Jun;34(6):1530-9
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Sengupta U, Prough DS, Jackson GR, DeWitt DS, Kayed R
The Journal of biological chemistry 2013 Jun 7;288(23):17042-17050
The Journal of biological chemistry 2013 Jun 7;288(23):17042-17050
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Cancino GI, Miller FD, Kaplan DR
Neurobiology of aging 2013 Feb;34(2):387-99
Neurobiology of aging 2013 Feb;34(2):387-99
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Morcinek K, Köhler C, Götz J, Schröder H
Brain research 2013 Feb 25;1497:73-84
Brain research 2013 Feb 25;1497:73-84
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, Herms J
Acta neuropathologica communications 2013 Dec 17;1:82
Acta neuropathologica communications 2013 Dec 17;1:82
Increased amyloid-β peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice.
Desrumaux C, Pisoni A, Meunier J, Deckert V, Athias A, Perrier V, Villard V, Lagrost L, Verdier JM, Maurice T
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Apr;38(5):817-25
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Apr;38(5):817-25
Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.
Iijima-Ando K, Sekiya M, Maruko-Otake A, Ohtake Y, Suzuki E, Lu B, Iijima KM
PLoS genetics 2012;8(8):e1002918
PLoS genetics 2012;8(8):e1002918
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
Castello NA, Green KN, LaFerla FM
PloS one 2012;7(8):e39566
PloS one 2012;7(8):e39566
Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.
Julien C, Marcouiller F, Bretteville A, El Khoury NB, Baillargeon J, Hébert SS, Planel E
PloS one 2012;7(6):e40020
PloS one 2012;7(6):e40020
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
Sudduth TL, Wilson JG, Everhart A, Colton CA, Wilcock DM
PloS one 2012;7(2):e31993
PloS one 2012;7(2):e31993
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J
PloS one 2012;7(12):e53547
PloS one 2012;7(12):e53547
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, Maruyama H, Ichikawa T, Obata F
PloS one 2012;7(1):e30834
PloS one 2012;7(1):e30834
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
Joshi YB, Chu J, Praticò D
Journal of Alzheimer's disease : JAD 2012;31(1):167-76
Journal of Alzheimer's disease : JAD 2012;31(1):167-76
Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis.
Ho YS, Yang X, Lau JC, Hung CH, Wuwongse S, Zhang Q, Wang J, Baum L, So KF, Chang RC
Journal of Alzheimer's disease : JAD 2012;28(4):839-54
Journal of Alzheimer's disease : JAD 2012;28(4):839-54
Dietary supplementation with S-adenosyl methionine delayed amyloid-β and tau pathology in 3xTg-AD mice.
Lee S, Lemere CA, Frost JL, Shea TB
Journal of Alzheimer's disease : JAD 2012;28(2):423-31
Journal of Alzheimer's disease : JAD 2012;28(2):423-31
Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model.
Lee S, Kim W, Li Z, Hall GF
International journal of Alzheimer's disease 2012;2012:172837
International journal of Alzheimer's disease 2012;2012:172837
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Bretteville A, Marcouiller F, Julien C, El Khoury NB, Petry FR, Poitras I, Mouginot D, Lévesque G, Hébert SS, Planel E
Scientific reports 2012;2:480
Scientific reports 2012;2:480
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A
Molecular neurodegeneration 2012 Sep 21;7:48
Molecular neurodegeneration 2012 Sep 21;7:48
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
Mondragón-Rodríguez S, Trillaud-Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, Boehm J
The Journal of biological chemistry 2012 Sep 14;287(38):32040-53
The Journal of biological chemistry 2012 Sep 14;287(38):32040-53
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Krüger U, Wang Y, Kumar S, Mandelkow EM
Neurobiology of aging 2012 Oct;33(10):2291-305
Neurobiology of aging 2012 Oct;33(10):2291-305
Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway.
Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, Ikeuchi T
The Journal of biological chemistry 2012 Oct 12;287(42):35222-33
The Journal of biological chemistry 2012 Oct 12;287(42):35222-33
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Löffler T, Flunkert S, Taub N, Schofield EL, Ward MA, Windisch M, Hutter-Paier B
Journal of molecular neuroscience : MN 2012 May;47(1):192-203
Journal of molecular neuroscience : MN 2012 May;47(1):192-203
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, Decarr LB, Yang L, Liu V, Fessler C, Protassio J, Riff T, Turner H, Janus CG, Sankaranarayanan S, Polson C, Meredith JE, Gray G, Hanna A, Olson RE, Kim SH, Vite GD, Lee FY, Albright CF
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May 23;32(21):7137-45
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May 23;32(21):7137-45
Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.
Jones NC, Nguyen T, Corcoran NM, Velakoulis D, Chen T, Grundy R, O'Brien TJ, Hovens CM
Neurobiology of disease 2012 Mar;45(3):897-901
Neurobiology of disease 2012 Mar;45(3):897-901
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Al-Shemary T
Neurotoxicology 2012 Jun;33(3):370-83
Neurotoxicology 2012 Jun;33(3):370-83
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.
Van der Jeugd A, Hochgräfe K, Ahmed T, Decker JM, Sydow A, Hofmann A, Wu D, Messing L, Balschun D, D'Hooge R, Mandelkow EM
Acta neuropathologica 2012 Jun;123(6):787-805
Acta neuropathologica 2012 Jun;123(6):787-805
First transgenic rat model developing progressive cortical neurofibrillary tangles.
Filipcik P, Zilka N, Bugos O, Kucerak J, Koson P, Novak P, Novak M
Neurobiology of aging 2012 Jul;33(7):1448-56
Neurobiology of aging 2012 Jul;33(7):1448-56
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Ksiezak-Reding H, Ho L, Santa-Maria I, Diaz-Ruiz C, Wang J, Pasinetti GM
Neurobiology of aging 2012 Jul;33(7):1427-39
Neurobiology of aging 2012 Jul;33(7):1427-39
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
Wang HY, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah SM, Burns LH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jul 18;32(29):9773-84
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jul 18;32(29):9773-84
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
Perez SE, Getova DP, He B, Counts SE, Geula C, Desire L, Coutadeur S, Peillon H, Ginsberg SD, Mufson EJ
The American journal of pathology 2012 Feb;180(2):526-40
The American journal of pathology 2012 Feb;180(2):526-40
Propagation of tau pathology in a model of early Alzheimer's disease.
de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT
Neuron 2012 Feb 23;73(4):685-97
Neuron 2012 Feb 23;73(4):685-97
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Attur S
Acta biologica Hungarica 2012 Dec;63(4):411-25
Acta biologica Hungarica 2012 Dec;63(4):411-25
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM
The American journal of pathology 2012 Aug;181(2):616-25
The American journal of pathology 2012 Aug;181(2):616-25
3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress.
Rothman SM, Herdener N, Camandola S, Texel SJ, Mughal MR, Cong WN, Martin B, Mattson MP
Neurobiology of aging 2012 Apr;33(4):830.e1-12
Neurobiology of aging 2012 Apr;33(4):830.e1-12
Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.
Minami SS, Clifford TG, Hoe HS, Matsuoka Y, Rebeck GW
Neurobiology of aging 2012 Apr;33(4):825.e15-24
Neurobiology of aging 2012 Apr;33(4):825.e15-24
Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.
Keilani S, Lun Y, Stevens AC, Williams HN, Sjoberg ER, Khanna R, Valenzano KJ, Checler F, Buxbaum JD, Yanagisawa K, Lockhart DJ, Wustman BA, Gandy S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Apr 11;32(15):5223-36
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Apr 11;32(15):5223-36
Degenerating processes identified by electron microscopic immunocytochemical methods.
Milner TA, Waters EM, Robinson DC, Pierce JP
Methods in molecular biology (Clifton, N.J.) 2011;793:23-59
Methods in molecular biology (Clifton, N.J.) 2011;793:23-59
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
Maarouf CL, Daugs ID, Kokjohn TA, Walker DG, Hunter JM, Kruchowsky JC, Woltjer R, Kaye J, Castaño EM, Sabbagh MN, Beach TG, Roher AE
PloS one 2011;6(11):e27291
PloS one 2011;6(11):e27291
Physical exercise protects against Alzheimer's disease in 3xTg-AD mice.
García-Mesa Y, López-Ramos JC, Giménez-Llort L, Revilla S, Guerra R, Gruart A, Laferla FM, Cristòfol R, Delgado-García JM, Sanfeliu C
Journal of Alzheimer's disease : JAD 2011;24(3):421-54
Journal of Alzheimer's disease : JAD 2011;24(3):421-54
Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model.
Tang JX, Mardini F, Caltagarone BM, Garrity ST, Li RQ, Bianchi SL, Gomes O, Laferla FM, Eckenhoff RG, Eckenhoff MF
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011 Sep;7(5):521-531.e1
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011 Sep;7(5):521-531.e1
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
Whitwell JL, Jack CR Jr, Przybelski SA, Parisi JE, Senjem ML, Boeve BF, Knopman DS, Petersen RC, Dickson DW, Josephs KA
Neurobiology of aging 2011 Sep;32(9):1531-41
Neurobiology of aging 2011 Sep;32(9):1531-41
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
McMillan PJ, Kraemer BC, Robinson L, Leverenz JB, Raskind M, Schellenberg G
Journal of neuropathology and experimental neurology 2011 Nov;70(11):1006-19
Journal of neuropathology and experimental neurology 2011 Nov;70(11):1006-19
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Koike MA, Garcia FG, Kitazawa M, Green KN, Laferla FM
Neuroscience letters 2011 May 9;495(1):55-9
Neuroscience letters 2011 May 9;495(1):55-9
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z, Lau K, Gray M, Bardag-Gorce F, Wiedau-Pazos M, Hui KS, Karsten SL
Human molecular genetics 2011 May 1;20(9):1820-33
Human molecular genetics 2011 May 1;20(9):1820-33
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):189-200
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):189-200
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 23;31(12):4720-30
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 23;31(12):4720-30
Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
PloS one 2011 Mar 15;6(3):e17971
PloS one 2011 Mar 15;6(3):e17971
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Takahashi RH, Tobiume M, Sato Y, Sata T, Gouras GK, Takahashi H
Neuropathology : official journal of the Japanese Society of Neuropathology 2011 Jun;31(3):208-14
Neuropathology : official journal of the Japanese Society of Neuropathology 2011 Jun;31(3):208-14
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
Tran HT, LaFerla FM, Holtzman DM, Brody DL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
Stieler JT, Bullmann T, Kohl F, Tøien Ø, Brückner MK, Härtig W, Barnes BM, Arendt T
PloS one 2011 Jan 18;6(1):e14530
PloS one 2011 Jan 18;6(1):e14530
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.
Niikura T, Sidahmed E, Hirata-Fukae C, Aisen PS, Matsuoka Y
PloS one 2011 Jan 17;6(1):e16259
PloS one 2011 Jan 17;6(1):e16259
Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation.
Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, Goate AM, Bird TD, Leverenz JB
Neuroscience letters 2011 Jan 10;487(3):287-92
Neuroscience letters 2011 Jan 10;487(3):287-92
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.
Ramirez JJ, Poulton WE, Knelson E, Barton C, King MA, Klein RL
Behavioural brain research 2011 Jan 1;216(1):332-40
Behavioural brain research 2011 Jan 1;216(1):332-40
Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.
Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J
Annals of neurology 2011 Feb;69(2):248-56
Annals of neurology 2011 Feb;69(2):248-56
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.
To AW, Ribe EM, Chuang TT, Schroeder JE, Lovestone S
PloS one 2011 Feb 10;6(2):e16991
PloS one 2011 Feb 10;6(2):e16991
Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model.
Jeong YH, Kim JM, Yoo J, Lee SH, Kim HS, Suh YH
Journal of neurochemistry 2011 Dec;119(6):1282-93
Journal of neurochemistry 2011 Dec;119(6):1282-93
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Kovacs GG, Molnár K, László L, Ströbel T, Botond G, Hönigschnabl S, Reiner-Concin A, Palkovits M, Fischer P, Budka H
Acta neuropathologica 2011 Aug;122(2):205-22
Acta neuropathologica 2011 Aug;122(2):205-22
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
Jayadev S, Nochlin D, Poorkaj P, Steinbart EJ, Mastrianni JA, Montine TJ, Ghetti B, Schellenberg GD, Bird TD, Leverenz JB
Annals of neurology 2011 Apr;69(4):712-20
Annals of neurology 2011 Apr;69(4):712-20
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 5;108(14):5819-24
Proceedings of the National Academy of Sciences of the United States of America 2011 Apr 5;108(14):5819-24
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Blazquez-Llorca L, Garcia-Marin V, Defelipe J
Frontiers in neuroanatomy 2010;4:20
Frontiers in neuroanatomy 2010;4:20
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN
Journal of Alzheimer's disease : JAD 2010;21(2):527-42
Journal of Alzheimer's disease : JAD 2010;21(2):527-42
3R tau expression modifies behavior in transgenic mice.
Shiryaev N, Jouroukhin Y, Gozes I
Journal of neuroscience research 2010 Sep;88(12):2727-35
Journal of neuroscience research 2010 Sep;88(12):2727-35
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE
Journal of neuropathology and experimental neurology 2010 Sep;69(9):918-29
Journal of neuropathology and experimental neurology 2010 Sep;69(9):918-29
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation.
Rodríguez-Navarro JA, Rodríguez L, Casarejos MJ, Solano RM, Gómez A, Perucho J, Cuervo AM, García de Yébenes J, Mena MA
Neurobiology of disease 2010 Sep;39(3):423-38
Neurobiology of disease 2010 Sep;39(3):423-38
Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease.
Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJ
The European journal of neuroscience 2010 Sep;32(6):905-20
The European journal of neuroscience 2010 Sep;32(6):905-20
Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.
Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ
The American journal of pathology 2010 Sep;177(3):1422-35
The American journal of pathology 2010 Sep;177(3):1422-35
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Minami SS, Sidahmed E, Aid S, Shimoji M, Niikura T, Mocchetti I, Rebeck GW, Prendergast JS, Dealwis C, Wetzel R, Bosetti F, Matsuoka Y, Hoe HS, Turner RS
Journal of neuroinflammation 2010 Sep 28;7:57
Journal of neuroinflammation 2010 Sep 28;7:57
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
Bertrand J, Sénéchal P, Zummo-Soucy M, Plouffe V, Leclerc N
Journal of neurochemistry 2010 Sep 1;114(5):1353-67
Journal of neurochemistry 2010 Sep 1;114(5):1353-67
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model.
Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM
The American journal of pathology 2010 Oct;177(4):1977-88
The American journal of pathology 2010 Oct;177(4):1977-88
Regulation of tau pathology by the microglial fractalkine receptor.
Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT
Neuron 2010 Oct 6;68(1):19-31
Neuron 2010 Oct 6;68(1):19-31
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
Peethumnongsin E, Yang L, Kallhoff-Muñoz V, Hu L, Takashima A, Pautler RG, Zheng H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 6;30(40):13409-18
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 6;30(40):13409-18
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
Zheng YL, Amin ND, Hu YF, Rudrabhatla P, Shukla V, Kanungo J, Kesavapany S, Grant P, Albers W, Pant HC
The Journal of biological chemistry 2010 Oct 29;285(44):34202-12
The Journal of biological chemistry 2010 Oct 29;285(44):34202-12
Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction.
Corona C, Masciopinto F, Silvestri E, Viscovo AD, Lattanzio R, Sorda RL, Ciavardelli D, Goglia F, Piantelli M, Canzoniero LM, Sensi SL
Cell death & disease 2010 Oct 28;1(10):e91
Cell death & disease 2010 Oct 28;1(10):e91
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 13;30(41):13707-17
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 13;30(41):13707-17
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease.
Stozicka Z, Zilka N, Novak P, Kovacech B, Bugos O, Novak M
Journal of neuroinflammation 2010 Oct 12;7:64
Journal of neuroinflammation 2010 Oct 12;7:64
Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice.
Giménez-Llort L, García Y, Buccieri K, Revilla S, Suñol C, Cristofol R, Sanfeliu C
International journal of Alzheimer's disease 2010 Oct 12;2010:128354
International journal of Alzheimer's disease 2010 Oct 12;2010:128354
A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.
Iijima-Ando K, Zhao L, Gatt A, Shenton C, Iijima K
Human molecular genetics 2010 May 15;19(10):1930-8
Human molecular genetics 2010 May 15;19(10):1930-8
Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy.
Soontornniyomkij V, Lynch MD, Mermash S, Pomakian J, Badkoobehi H, Clare R, Vinters HV
Brain pathology (Zurich, Switzerland) 2010 Mar;20(2):459-67
Brain pathology (Zurich, Switzerland) 2010 Mar;20(2):459-67
Amyloid and Tau accumulate in the brains of aged hydrocephalic rats.
Silverberg GD, Miller MC, Machan JT, Johanson CE, Caralopoulos IN, Pascale CL, Heile A, Klinge PM
Brain research 2010 Mar 4;1317:286-96
Brain research 2010 Mar 4;1317:286-96
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Bertrand J, Plouffe V, Sénéchal P, Leclerc N
Neuroscience 2010 Jun 30;168(2):323-34
Neuroscience 2010 Jun 30;168(2):323-34
Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK
Neurobiology of aging 2010 Jul;31(7):1145-52
Neurobiology of aging 2010 Jul;31(7):1145-52
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Koike MA, Green KN, Blurton-Jones M, Laferla FM
The American journal of pathology 2010 Jul;177(1):300-10
The American journal of pathology 2010 Jul;177(1):300-10
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
Bigio EH, Mishra M, Hatanpaa KJ, White CL 3rd, Johnson N, Rademaker A, Weitner BB, Deng HX, Dubner SD, Weintraub S, Mesulam M
Acta neuropathologica 2010 Jul;120(1):43-54
Acta neuropathologica 2010 Jul;120(1):43-54
A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity.
Poorkaj P, Raskind WH, Leverenz JB, Matsushita M, Zabetian CP, Samii A, Kim S, Gazi N, Nutt JG, Wolff J, Yearout D, Greenup JL, Steinbart EJ, Bird TD
Movement disorders : official journal of the Movement Disorder Society 2010 Jul 30;25(10):1409-17
Movement disorders : official journal of the Movement Disorder Society 2010 Jul 30;25(10):1409-17
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB
PLoS genetics 2010 Jul 15;6(7):e1001026
PLoS genetics 2010 Jul 15;6(7):e1001026
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease.
Josephs KA, Whitwell JL, Boeve BF, Knopman DS, Petersen RC, Hu WT, Parisi JE, Dickson DW, Jack CR Jr
Movement disorders : official journal of the Movement Disorder Society 2010 Jul 15;25(9):1246-52
Movement disorders : official journal of the Movement Disorder Society 2010 Jul 15;25(9):1246-52
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.
Capucchio MT, Márquez M, Pregel P, Foradada L, Bravo M, Mattutino G, Torre C, Schiffer D, Catalano D, Valenza F, Guarda F, Pumarola M
Journal of comparative pathology 2010 Jan;142(1):61-73
Journal of comparative pathology 2010 Jan;142(1):61-73
Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5.
Lopes JP, Oliveira CR, Agostinho P
Aging cell 2010 Feb;9(1):64-77
Aging cell 2010 Feb;9(1):64-77
Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.
Grueninger F, Bohrmann B, Czech C, Ballard TM, Frey JR, Weidensteiner C, von Kienlin M, Ozmen L
Neurobiology of disease 2010 Feb;37(2):294-306
Neurobiology of disease 2010 Feb;37(2):294-306
Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.
Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group
Neuropathology and applied neurobiology 2010 Feb;36(1):25-40
Neuropathology and applied neurobiology 2010 Feb;36(1):25-40
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM
The American journal of pathology 2010 Feb;176(2):870-80
The American journal of pathology 2010 Feb;176(2):870-80
Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ
Molecular therapy : the journal of the American Society of Gene Therapy 2010 Aug;18(8):1471-81
Molecular therapy : the journal of the American Society of Gene Therapy 2010 Aug;18(8):1471-81
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
Köhler C, Bista P, Götz J, Schröder H
Brain research 2010 Aug 6;1347:111-24
Brain research 2010 Aug 6;1347:111-24
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Mohorko N, Repovs G, Popović M, Kovacs GG, Bresjanac M
Journal of neuropathology and experimental neurology 2010 Apr;69(4):405-14
Journal of neuropathology and experimental neurology 2010 Apr;69(4):405-14
Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases.
Wang GR, Shi S, Gao C, Zhang BY, Tian C, Dong CF, Zhou RM, Li XL, Chen C, Han J, Dong XP
BMC infectious diseases 2010 Apr 1;10:86
BMC infectious diseases 2010 Apr 1;10:86
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
Capsoni S, Covaceuszach S, Ugolini G, Spirito F, Vignone D, Stefanini B, Amato G, Cattaneo A
Journal of Alzheimer's disease : JAD 2009;16(2):371-88
Journal of Alzheimer's disease : JAD 2009;16(2):371-88
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
van Eersel J, Bi M, Ke YD, Hodges JR, Xuereb JH, Gregory GC, Halliday GM, Götz J, Kril JJ, Ittner LM
Journal of neural transmission (Vienna, Austria : 1996) 2009 Oct;116(10):1243-51
Journal of neural transmission (Vienna, Austria : 1996) 2009 Oct;116(10):1243-51
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, Kauselmann G, Zevnik B, Henriksen G, Drzezga A, Pohlner J, Schoor M, Kemp JA, von der Kammer H
PloS one 2009 Nov 20;4(11):e7931
PloS one 2009 Nov 20;4(11):e7931
Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.
Perreault S, Bousquet O, Lauzon M, Paiement J, Leclerc N
Journal of neuropathology and experimental neurology 2009 May;68(5):503-14
Journal of neuropathology and experimental neurology 2009 May;68(5):503-14
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Ohmi K, Kudo LC, Ryazantsev S, Zhao HZ, Karsten SL, Neufeld EF
Proceedings of the National Academy of Sciences of the United States of America 2009 May 19;106(20):8332-7
Proceedings of the National Academy of Sciences of the United States of America 2009 May 19;106(20):8332-7
PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation.
Stieler JT, Bullmann T, Kohl F, Barnes BM, Arendt T
Journal of neural transmission (Vienna, Austria : 1996) 2009 Mar;116(3):345-50
Journal of neural transmission (Vienna, Austria : 1996) 2009 Mar;116(3):345-50
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jun 24;29(25):7957-65
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jun 24;29(25):7957-65
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA
Journal of neuropathology and experimental neurology 2009 Jul;68(7):709-35
Journal of neuropathology and experimental neurology 2009 Jul;68(7):709-35
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
Ittner LM, Ke YD, Götz J
The Journal of biological chemistry 2009 Jul 31;284(31):20909-16
The Journal of biological chemistry 2009 Jul 31;284(31):20909-16
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
Rahman A, Ting K, Cullen KM, Braidy N, Brew BJ, Guillemin GJ
PloS one 2009 Jul 22;4(7):e6344
PloS one 2009 Jul 22;4(7):e6344
A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau.
Brandt R, Gergou A, Wacker I, Fath T, Hutter H
Neurobiology of aging 2009 Jan;30(1):22-33
Neurobiology of aging 2009 Jan;30(1):22-33
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Wiedau-Pazos M, Wong E, Solomon E, Alarcon M, Geschwind DH
Neurobiology of aging 2009 Jan;30(1):14-21
Neurobiology of aging 2009 Jan;30(1):14-21
Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.
Shehadeh L, Mitsi G, Adi N, Bishopric N, Papapetropoulos S
Movement disorders : official journal of the Movement Disorder Society 2009 Jan 30;24(2):204-10
Movement disorders : official journal of the Movement Disorder Society 2009 Jan 30;24(2):204-10
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Chatterjee S, Sang TK, Lawless GM, Jackson GR
Human molecular genetics 2009 Jan 1;18(1):164-77
Human molecular genetics 2009 Jan 1;18(1):164-77
Rapidly progressive neurodegenerative dementias.
Josephs KA, Ahlskog JE, Parisi JE, Boeve BF, Crum BA, Giannini C, Petersen RC
Archives of neurology 2009 Feb;66(2):201-7
Archives of neurology 2009 Feb;66(2):201-7
Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease.
Sikorska B, Liberski PP, Sobów T, Budka H, Ironside JW
Neuropathology and applied neurobiology 2009 Feb;35(1):46-59
Neuropathology and applied neurobiology 2009 Feb;35(1):46-59
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
Ojala J, Alafuzoff I, Herukka SK, van Groen T, Tanila H, Pirttilä T
Neurobiology of aging 2009 Feb;30(2):198-209
Neurobiology of aging 2009 Feb;30(2):198-209
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Bitner RS, Nikkel AL, Markosyan S, Otte S, Puttfarcken P, Gopalakrishnan M
Brain research 2009 Apr 10;1265:65-74
Brain research 2009 Apr 10;1265:65-74
Age and apoE associations with complex pathologic features in Alzheimer's disease.
Jicha GA, Parisi JE, Dickson DW, Cha RH, Johnson KA, Smith GE, Boeve BF, Petersen RC, Knopman DS
Journal of the neurological sciences 2008 Oct 15;273(1-2):34-9
Journal of the neurological sciences 2008 Oct 15;273(1-2):34-9
Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice.
Rodríguez-Navarro JA, Gómez A, Rodal I, Perucho J, Martinez A, Furió V, Ampuero I, Casarejos MJ, Solano RM, de Yébenes JG, Mena MA
Human molecular genetics 2008 Oct 15;17(20):3128-43
Human molecular genetics 2008 Oct 15;17(20):3128-43
Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation.
Song MS, Rauw G, Baker GB, Kar S
The European journal of neuroscience 2008 Nov;28(10):1989-2002
The European journal of neuroscience 2008 Nov;28(10):1989-2002
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP
The Journal of clinical investigation 2008 May;118(5):1877-89
The Journal of clinical investigation 2008 May;118(5):1877-89
Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation.
Hinners I, Hill A, Otto U, Michalsky A, Mack TG, Striggow F
Molecular and cellular neurosciences 2008 Mar;37(3):559-67
Molecular and cellular neurosciences 2008 Mar;37(3):559-67
ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation.
Resende R, Ferreiro E, Pereira C, Oliveira CR
Journal of neuroscience research 2008 Jul;86(9):2091-9
Journal of neuroscience research 2008 Jul;86(9):2091-9
Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
Thakur A, Siedlak SL, James SL, Bonda DJ, Rao A, Webber KM, Camins A, Pallàs M, Casadesus G, Lee HG, Bowser R, Raina AK, Perry G, Smith MA, Zhu X
International journal of clinical and experimental pathology 2008 Jan 1;1(2):134-46
International journal of clinical and experimental pathology 2008 Jan 1;1(2):134-46
Beta-amyloid burden is not associated with rates of brain atrophy.
Josephs KA, Whitwell JL, Ahmed Z, Shiung MM, Weigand SD, Knopman DS, Boeve BF, Parisi JE, Petersen RC, Dickson DW, Jack CR Jr
Annals of neurology 2008 Feb;63(2):204-12
Annals of neurology 2008 Feb;63(2):204-12
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, Vitek MP, Colton CA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Feb 13;28(7):1537-45
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Feb 13;28(7):1537-45
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG
Age (Dordrecht, Netherlands) 2008 Dec;30(4):209-15
Age (Dordrecht, Netherlands) 2008 Dec;30(4):209-15
Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells.
Ojala JO, Sutinen EM, Salminen A, Pirttilä T
Journal of neuroimmunology 2008 Dec 15;205(1-2):86-93
Journal of neuroimmunology 2008 Dec 15;205(1-2):86-93
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.
Matsuoka Y, Jouroukhin Y, Gray AJ, Ma L, Hirata-Fukae C, Li HF, Feng L, Lecanu L, Walker BR, Planel E, Arancio O, Gozes I, Aisen PS
The Journal of pharmacology and experimental therapeutics 2008 Apr;325(1):146-53
The Journal of pharmacology and experimental therapeutics 2008 Apr;325(1):146-53
Argyrophilic grains: a distinct disease or an additive pathology?
Josephs KA, Whitwell JL, Parisi JE, Knopman DS, Boeve BF, Geda YE, Jack CR Jr, Petersen RC, Dickson DW
Neurobiology of aging 2008 Apr;29(4):566-73
Neurobiology of aging 2008 Apr;29(4):566-73
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Preusser M, Kitzwoegerer M, Budka H, Brugger S
Neuropathology : official journal of the Japanese Society of Neuropathology 2007 Oct;27(5):453-6
Neuropathology : official journal of the Japanese Society of Neuropathology 2007 Oct;27(5):453-6
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Preusser M, Kitzwoegerer M, Budka H, Brugger S
Neuropathology : official journal of the Japanese Society of Neuropathology 2007 Oct;27(5):453-6
Neuropathology : official journal of the Japanese Society of Neuropathology 2007 Oct;27(5):453-6
Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia.
Munoz DG, Woulfe J, Kertesz A
Acta neuropathologica 2007 Oct;114(4):347-57
Acta neuropathologica 2007 Oct;114(4):347-57
Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline.
Piggott MA, Ballard CG, Rowan E, Holmes C, McKeith IG, Jaros E, Perry RH, Perry EK
Synapse (New York, N.Y.) 2007 Nov;61(11):903-11
Synapse (New York, N.Y.) 2007 Nov;61(11):903-11
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
Caccamo A, Oddo S, Tran LX, LaFerla FM
The American journal of pathology 2007 May;170(5):1669-75
The American journal of pathology 2007 May;170(5):1669-75
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Leverenz JB, Yu CE, Montine TJ, Steinbart E, Bekris LM, Zabetian C, Kwong LK, Lee VM, Schellenberg GD, Bird TD
Brain : a journal of neurology 2007 May;130(Pt 5):1360-74
Brain : a journal of neurology 2007 May;130(Pt 5):1360-74
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G
Proceedings of the National Academy of Sciences of the United States of America 2007 May 29;104(22):9511-6
Proceedings of the National Academy of Sciences of the United States of America 2007 May 29;104(22):9511-6
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Evans TA, Raina AK, Delacourte A, Aprelikova O, Lee HG, Zhu X, Perry G, Smith MA
International journal of medical sciences 2007 May 12;4(3):140-5
International journal of medical sciences 2007 May 12;4(3):140-5
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
Evans TA, Raina AK, Delacourte A, Aprelikova O, Lee HG, Zhu X, Perry G, Smith MA
International journal of medical sciences 2007 May 12;4(3):140-5
International journal of medical sciences 2007 May 12;4(3):140-5
Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.
Grudzien A, Shaw P, Weintraub S, Bigio E, Mash DC, Mesulam MM
Neurobiology of aging 2007 Mar;28(3):327-35
Neurobiology of aging 2007 Mar;28(3):327-35
Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
Dias-Santagata D, Fulga TA, Duttaroy A, Feany MB
The Journal of clinical investigation 2007 Jan;117(1):236-45
The Journal of clinical investigation 2007 Jan;117(1):236-45
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Josephs KA, Ahmed Z, Katsuse O, Parisi JF, Boeve BF, Knopman DS, Petersen RC, Davies P, Duara R, Graff-Radford NR, Uitti RJ, Rademakers R, Adamson J, Baker M, Hutton ML, Dickson DW
Journal of neuropathology and experimental neurology 2007 Feb;66(2):142-51
Journal of neuropathology and experimental neurology 2007 Feb;66(2):142-51
Inflammatory changes parallel the early stages of Alzheimer disease.
Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW
Neurobiology of aging 2007 Dec;28(12):1821-33
Neurobiology of aging 2007 Dec;28(12):1821-33
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, Yu WH, Luchsinger JA, Wadzinski B, Duff KE, Takashima A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Dec 12;27(50):13635-48
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Dec 12;27(50):13635-48
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM
Journal of neurochemistry 2007 Aug;102(4):1053-63
Journal of neurochemistry 2007 Aug;102(4):1053-63
Rates of cerebral atrophy differ in different degenerative pathologies.
Whitwell JL, Jack CR Jr, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Ferman TJ, Dickson DW, Josephs KA
Brain : a journal of neurology 2007 Apr;130(Pt 4):1148-58
Brain : a journal of neurology 2007 Apr;130(Pt 4):1148-58
Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia.
Piggott MA, Ballard CG, Dickinson HO, McKeith IG, Perry RH, Perry EK
The international journal of neuropsychopharmacology 2007 Apr;10(2):231-44
The international journal of neuropsychopharmacology 2007 Apr;10(2):231-44
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr 18;27(16):4385-95
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr 18;27(16):4385-95
Cognitive impairment and celiac disease.
Hu WT, Murray JA, Greenaway MC, Parisi JE, Josephs KA
Archives of neurology 2006 Oct;63(10):1440-6
Archives of neurology 2006 Oct;63(10):1440-6
Tau interacts with Golgi membranes and mediates their association with microtubules.
Farah CA, Perreault S, Liazoghli D, Desjardins M, Anton A, Lauzon M, Paiement J, Leclerc N
Cell motility and the cytoskeleton 2006 Nov;63(11):710-24
Cell motility and the cytoskeleton 2006 Nov;63(11):710-24
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Boeve BF, Baker M, Dickson DW, Parisi JE, Giannini C, Josephs KA, Hutton M, Pickering-Brown SM, Rademakers R, Tang-Wai D, Jack CR Jr, Kantarci K, Shiung MM, Golde T, Smith GE, Geda YE, Knopman DS, Petersen RC
Brain : a journal of neurology 2006 Nov;129(Pt 11):3103-14
Brain : a journal of neurology 2006 Nov;129(Pt 11):3103-14
Memory complaints are related to Alzheimer disease pathology in older persons.
Barnes LL, Schneider JA, Boyle PA, Bienias JL, Bennett DA
Neurology 2006 Nov 14;67(9):1581-5
Neurology 2006 Nov 14;67(9):1581-5
Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.
Jicha GA, Parisi JE, Dickson DW, Johnson K, Cha R, Ivnik RJ, Tangalos EG, Boeve BF, Knopman DS, Braak H, Petersen RC
Archives of neurology 2006 May;63(5):674-81
Archives of neurology 2006 May;63(5):674-81
Neuropathologic features of amnestic mild cognitive impairment.
Petersen RC, Parisi JE, Dickson DW, Johnson KA, Knopman DS, Boeve BF, Jicha GA, Ivnik RJ, Smith GE, Tangalos EG, Braak H, Kokmen E
Archives of neurology 2006 May;63(5):665-72
Archives of neurology 2006 May;63(5):665-72
Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations.
Papapetropoulos S, McCorquodale DS, Gonzalez J, Jean-Gilles L, Mash DC
Parkinsonism & related disorders 2006 May;12(4):253-6
Parkinsonism & related disorders 2006 May;12(4):253-6
Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension.
Oka T, Tamada Y, Nakajima E, Shearer TR, Azuma M
Journal of neuroscience research 2006 May 15;83(7):1342-51
Journal of neuroscience research 2006 May 15;83(7):1342-51
Neuropathology in the S305S tau gene mutation.
Halliday GM, Song YJ, Creasey H, Morris JG, Brooks WS, Kril JJ
Brain : a journal of neurology 2006 Mar;129(Pt 3):E40
Brain : a journal of neurology 2006 Mar;129(Pt 3):E40
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment.
Jicha GA, Petersen RC, Knopman DS, Boeve BF, Smith GE, Geda YE, Johnson KA, Cha R, Delucia MW, Braak H, Dickson DW, Parisi JE
Journal of neuropathology and experimental neurology 2006 Jun;65(6):602-9
Journal of neuropathology and experimental neurology 2006 Jun;65(6):602-9
The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease.
Galas MC, Dourlen P, Bégard S, Ando K, Blum D, Hamdane M, Buée L
The Journal of biological chemistry 2006 Jul 14;281(28):19296-304
The Journal of biological chemistry 2006 Jul 14;281(28):19296-304
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
Quintana C, Bellefqih S, Laval JY, Guerquin-Kern JL, Wu TD, Avila J, Ferrer I, Arranz R, Patiño C
Journal of structural biology 2006 Jan;153(1):42-54
Journal of structural biology 2006 Jan;153(1):42-54
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
Wahle T, Thal DR, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, Heneka MT, Walter J
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Dec 6;26(49):12838-46
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Dec 6;26(49):12838-46
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM
The Journal of biological chemistry 2006 Dec 22;281(51):39413-23
The Journal of biological chemistry 2006 Dec 22;281(51):39413-23
Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits.
Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ
Journal of feline medicine and surgery 2006 Aug;8(4):234-42
Journal of feline medicine and surgery 2006 Aug;8(4):234-42
High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus.
Ghribi O, Larsen B, Schrag M, Herman MM
Experimental neurology 2006 Aug;200(2):460-7
Experimental neurology 2006 Aug;200(2):460-7
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.
Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Aug 30;26(35):9047-56
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Aug 30;26(35):9047-56
Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation.
Sakaue M, Okazaki M, Hara S
Toxicology 2005 Sep 15;213(1-2):97-106
Toxicology 2005 Sep 15;213(1-2):97-106
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Yang W, Ang LC, Strong MJ
Brain research. Developmental brain research 2005 May 12;156(2):127-38
Brain research. Developmental brain research 2005 May 12;156(2):127-38
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Yang W, Ang LC, Strong MJ
Brain research. Developmental brain research 2005 May 12;156(2):127-38
Brain research. Developmental brain research 2005 May 12;156(2):127-38
Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates.
Fukuda T, Shimizu J, Furuhata H, Abe T, Shimizu K, Oishi T, Ogihara M, Kubota J, Sasaki A, Sasaki K, Azuma T, Umemura S
Acta neuropathologica 2005 Aug;110(2):145-50
Acta neuropathologica 2005 Aug;110(2):145-50
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.
Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E
Acta neuropathologica 2005 Aug;110(2):135-44
Acta neuropathologica 2005 Aug;110(2):135-44
Antemortem diagnosis of frontotemporal lobar degeneration.
Knopman DS, Boeve BF, Parisi JE, Dickson DW, Smith GE, Ivnik RJ, Josephs KA, Petersen RC
Annals of neurology 2005 Apr;57(4):480-8
Annals of neurology 2005 Apr;57(4):480-8
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Frasier M, Walzer M, McCarthy L, Magnuson D, Lee JM, Haas C, Kahle P, Wolozin B
Experimental neurology 2005 Apr;192(2):274-87
Experimental neurology 2005 Apr;192(2):274-87
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y
The Journal of biological chemistry 2004 Oct 22;279(43):44795-801
The Journal of biological chemistry 2004 Oct 22;279(43):44795-801
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Mar 10;24(10):2527-34
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Mar 10;24(10):2527-34
Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease.
Heckmann JM, Low WC, de Villiers C, Rutherfoord S, Vorster A, Rao H, Morris CM, Ramesar RS, Kalaria RN
Brain : a journal of neurology 2004 Jan;127(Pt 1):133-42
Brain : a journal of neurology 2004 Jan;127(Pt 1):133-42
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
Li G, Yin H, Kuret J
The Journal of biological chemistry 2004 Apr 16;279(16):15938-45
The Journal of biological chemistry 2004 Apr 16;279(16):15938-45
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10966-71
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10966-71
Neuropathology of cognitively normal elderly.
Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC
Journal of neuropathology and experimental neurology 2003 Nov;62(11):1087-95
Journal of neuropathology and experimental neurology 2003 Nov;62(11):1087-95
Neuropathology of cognitively normal elderly.
Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, Smith GE, Dickson DW, Johnson KA, Petersen LE, McDonald WC, Braak H, Petersen RC
Journal of neuropathology and experimental neurology 2003 Nov;62(11):1087-95
Journal of neuropathology and experimental neurology 2003 Nov;62(11):1087-95
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Tang-Wai DF, Josephs KA, Boeve BF, Petersen RC, Parisi JE, Dickson DW
Journal of neurology, neurosurgery, and psychiatry 2003 Mar;74(3):389
Journal of neurology, neurosurgery, and psychiatry 2003 Mar;74(3):389
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Tang-Wai DF, Josephs KA, Boeve BF, Petersen RC, Parisi JE, Dickson DW
Journal of neurology, neurosurgery, and psychiatry 2003 Mar;74(3):389
Journal of neurology, neurosurgery, and psychiatry 2003 Mar;74(3):389
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Zhu X, Sun Z, Lee HG, Siedlak SL, Perry G, Smith MA
Journal of neurochemistry 2003 Jul;86(1):136-42
Journal of neurochemistry 2003 Jul;86(1):136-42
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Zhu X, Sun Z, Lee HG, Siedlak SL, Perry G, Smith MA
Journal of neurochemistry 2003 Jul;86(1):136-42
Journal of neurochemistry 2003 Jul;86(1):136-42
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Yoshida H, Goedert M
Biochemistry 2002 Dec 24;41(51):15203-11
Biochemistry 2002 Dec 24;41(51):15203-11
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Yoshida H, Goedert M
Biochemistry 2002 Dec 24;41(51):15203-11
Biochemistry 2002 Dec 24;41(51):15203-11
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Sep 1;21(17):6758-71
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Sep 1;21(17):6758-71
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Sep 1;21(17):6758-71
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Sep 1;21(17):6758-71
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW
Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 17;98(15):8838-43
Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 17;98(15):8838-43
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA
Mechanisms of ageing and development 2001 Dec;123(1):39-46
Mechanisms of ageing and development 2001 Dec;123(1):39-46
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA
Mechanisms of ageing and development 2001 Dec;123(1):39-46
Mechanisms of ageing and development 2001 Dec;123(1):39-46
Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments.
King ME, Ghoshal N, Wall JS, Binder LI, Ksiezak-Reding H
The American journal of pathology 2001 Apr;158(4):1481-90
The American journal of pathology 2001 Apr;158(4):1481-90
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
Braak E, Braak H, Mandelkow EM
Acta neuropathologica 1994;87(6):554-67
Acta neuropathologica 1994;87(6):554-67
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
Braak E, Braak H, Mandelkow EM
Acta neuropathologica 1994;87(6):554-67
Acta neuropathologica 1994;87(6):554-67
Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes.
Mercken M, Vandermeeren M, Lübke U, Six J, Boons J, Van de Voorde A, Martin JJ, Gheuens J
Acta neuropathologica 1992;84(3):265-72
Acta neuropathologica 1992;84(3):265-72
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Supportive validation
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- Western blot analysis of protein extracts from untransfected (-) embryonic neuronal rat cells (eNRC) and HEK293 cells, and eNRC and HEK293 cells expressing (+) human-Tau 4R/2N. eNRC cells were transiently transfected with a lentiviral vector containing the coding region of human-Tau 4R/2N, whereas HEK293 cells stably express human-Tau 4R/2N. Equal amounts of untransfected and transfected eNRC lysates (10 µg each) and HEK293 cell lysates (20 µg each) were loaded per lane, and blots were probed with MN1040 (1:500) to detect phospho-PHF-tau. Data courtesy of the Innovators Program.
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of protein extracts from untransfected (-) embryonic neuronal rat cells (eNRC) and HEK293 cells, and eNRC and HEK293 cells expressing (+) human-Tau 4R/2N. eNRC cells were transiently transfected with a lentiviral vector containing the coding region of human-Tau 4R/2N, whereas HEK293 cells stably express human-Tau 4R/2N. Equal amounts of untransfected and transfected eNRC lysates (10 µg each) and HEK293 cell lysates (20 µg each) were loaded per lane, and blots were probed with MN1040 (1:500) to detect phospho-PHF-tau. Data courtesy of the Innovators Program.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
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- Figure 6 Abeta 1-42 treatment increases pathological tau recognized by AT180 when compared with Abeta 1-40 treatment. Brain sections were immunostained with AT180, which recognizes p-tau at Thr 231 . (A) Representative images for pathological tau detected with AT180. (B) Higher magnification showed significantly increased tau tangles in Abeta1-42 injected entorhinal cortex (C) and hippocampus (B) . Magnification: 4x for A; 10x for B and C. Scale bar: 100um.
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- Figure 1 Tau acetylation modulates tau phosphorylation at specific epitopes. (a-c ) Immunoblot analysis and quantification using the indicated tau antibodies for (a ) cells expressing WT tau-T40 and either an active form of CBP or a catalytically inactive form of CBP (CBP-LD), ( b ) cells co- expressing tau-T40 (WT, DeltaKK, 4KQ, or 4KR) and tau modifying enzymes, and ( c ) cells expressing tau-T40 (WT, DeltaKK, 2KQ, 4KQ, or 4KR) and treated with control (DMSO) or okadaic acid (OA), where indicated. Solid black arrows highlight the ~75 kDa phospho-tau species that is reduced upon acetylation. Statistical significance was assessed using a student t-test (****p < 0.0001). Cropped images from full size immunoblots are provided in panels a-c. Full-length immunoblots are presented in Supplementary Fig. S1 . ( d ) Immunofluorescence microscopy of primary cortical neurons expressing WT-tau-GFP (left) or 4KQ-tau-GFP (right) detecting phosphorylated tau (AT8). White arrows identify transfected neurons. Scale bar, 50 um.
