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antibody from Invitrogen Antibodies
Targeting: MAPT
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau
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- Antibody Data
- Antigen structure
- References [164]
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- Product number
- MN1060 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Phospho-Tau (Thr212, Ser214) Monoclonal Antibody (AT100)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Description
- MN1060 recognized PHF-Tau. No cross reactivity with normal biopsy-or-autopsy-derived Tau or fetal Tau has been observed. This suggests that this antibody detects an abnormal phosphorylation site unique to PHF-Tau. The epitope of this antibody has been show to contain phosphorylated Ser214 and phosphorylated Thr212 residues (numbering according to human Tau40). MN1060 detects PHF-tau (Thr212/Ser214) which has a predicted molecular weight of approximately 79 kDa. This product is a Low Endotoxin formulation. Purity is >95% as determined by SDS-PAGE.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- AT100
- Vial size
- 100 µg
- Concentration
- 0.2 mg/mL
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro.
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.
Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study.
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease.
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy.
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
A Low Cost Antibody Signal Enhancer Improves Immunolabeling in Cell Culture, Primate Brain and Human Cancer Biopsy.
Initiation of Parkinson's disease from gut to brain by δ-secretase.
Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation.
Effects of Amylin Against Amyloid-β-Induced Tauopathy and Synapse Loss in Primary Neurons.
Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports.
N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain.
Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.
In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain.
Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice.
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator.
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation.
Cryo-EM structures of tau filaments from Alzheimer's disease.
HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.
Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies.
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.
Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters.
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia.
Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice.
The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments.
Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology.
Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice.
Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex.
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.
The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease.
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo.
Different Brain Regions are Infected with Fungi in Alzheimer's Disease.
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.
The domestic cat as a natural animal model of Alzheimer's disease.
Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
Piericidin A aggravates Tau pathology in P301S transgenic mice.
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
PINCH in the cellular stress response to tau-hyperphosphorylation.
Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies.
Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients.
Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease.
Increased amyloid-β peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice.
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats.
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S.
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
First transgenic rat model developing progressive cortical neurofibrillary tangles.
The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice.
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
Axonal inclusions in spinocerebellar ataxia type 3.
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Transmission and spreading of tauopathy in transgenic mouse brain.
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes.
A new function of microtubule-associated protein tau: involvement in chromosome stability.
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
Cell type-specific processing of human Tau proteins in Drosophila.
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein.
de Oliveira P, Cella C, Locker N, Ravindran KKG, Mendis A, Wafford K, Gilmour G, Dijk DJ, Winsky-Sommerer R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Apr 20;42(16):3494-3509
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Apr 20;42(16):3494-3509
Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro.
Asada-Utsugi M, Uemura K, Ayaki T, T Uemura M, Minamiyama S, Hikiami R, Morimura T, Shodai A, Ueki T, Takahashi R, Kinoshita A, Urushitani M
Communications biology 2022 Apr 13;5(1):358
Communications biology 2022 Apr 13;5(1):358
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Omoluabi T, Torraville SE, Maziar A, Ghosh A, Power KD, Reinhardt C, Harley CW, Yuan Q
Alzheimer's & dementia (New York, N. Y.) 2021;7(1):e12231
Alzheimer's & dementia (New York, N. Y.) 2021;7(1):e12231
Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.
Haytural H, Jordà-Siquier T, Winblad B, Mulle C, Tjernberg LO, Granholm AC, Frykman S, Barthet G
Brain communications 2021;3(2):fcab079
Brain communications 2021;3(2):fcab079
Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study.
Ahmad F, Mein H, Jing Y, Zhang H, Liu P
International journal of molecular sciences 2021 Sep 8;22(18)
International journal of molecular sciences 2021 Sep 8;22(18)
Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.
Lam S, Petit F, Hérard AS, Boluda S, Eddarkaoui S, Guillermier M, Brain Bank Neuro-C. E. B. Neuropathology Network, Buée L, Duyckaerts C, Haïk S, Picq JL, Dhenain M
Acta neuropathologica communications 2021 Oct 12;9(1):165
Acta neuropathologica communications 2021 Oct 12;9(1):165
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, Zhang Z, Cao X, Wang T, Tang L, Ye K, Zhang Z
eLife 2021 May 21;10
eLife 2021 May 21;10
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA
Acta neuropathologica communications 2021 Mar 12;9(1):41
Acta neuropathologica communications 2021 Mar 12;9(1):41
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Bichmann M, Prat Oriol N, Ercan-Herbst E, Schöndorf DC, Gomez Ramos B, Schwärzler V, Neu M, Schlüter A, Wang X, Jin L, Hu C, Tian Y, Ried JS, Haberkant P, Gasparini L, Ehrnhoefer DE
Molecular neurodegeneration 2021 Jul 2;16(1):46
Molecular neurodegeneration 2021 Jul 2;16(1):46
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease.
Brigas HC, Ribeiro M, Coelho JE, Gomes R, Gomez-Murcia V, Carvalho K, Faivre E, Costa-Pereira S, Darrigues J, de Almeida AA, Buée L, Dunot J, Marie H, Pousinha PA, Blum D, Silva-Santos B, Lopes LV, Ribot JC
Cell reports 2021 Aug 31;36(9):109574
Cell reports 2021 Aug 31;36(9):109574
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, Marcilla I, Marti-Andres G, Caballero MC, Riverol M, Tuñon MT, Fraser PE, Luquin MR
Acta neuropathologica communications 2021 Apr 8;9(1):64
Acta neuropathologica communications 2021 Apr 8;9(1):64
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy.
Ni R, Chen Z, Gerez JA, Shi G, Zhou Q, Riek R, Nilsson KPR, Razansky D, Klohs J
Biomedical optics express 2020 Sep 1;11(9):4989-5002
Biomedical optics express 2020 Sep 1;11(9):4989-5002
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF
Scientific reports 2020 Jul 30;10(1):12827
Scientific reports 2020 Jul 30;10(1):12827
A Low Cost Antibody Signal Enhancer Improves Immunolabeling in Cell Culture, Primate Brain and Human Cancer Biopsy.
Flores-Maldonado C, Albino-Sánchez ME, Rodríguez-Callejas JD, Estrada-Mondragon A, León-Galicia I, Maqueda-Alfaro R, Perez-Cruz C, Fuchs E, García-Carrancá A, Contreras RG, Missirlis F, Rosas-Arellano A
Neuroscience 2020 Jul 15;439:275-286
Neuroscience 2020 Jul 15;439:275-286
Initiation of Parkinson's disease from gut to brain by δ-secretase.
Ahn EH, Kang SS, Liu X, Chen G, Zhang Z, Chandrasekharan B, Alam AM, Neish AS, Cao X, Ye K
Cell research 2020 Jan;30(1):70-87
Cell research 2020 Jan;30(1):70-87
Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation.
Das R, Balmik AA, Chinnathambi S
ASN neuro 2020 Jan-Dec;12:1759091420981204
ASN neuro 2020 Jan-Dec;12:1759091420981204
Effects of Amylin Against Amyloid-β-Induced Tauopathy and Synapse Loss in Primary Neurons.
Gan Q, Yao H, Na H, Ballance H, Tao Q, Leung L, Tian H, Zhu H, Wolozin B, Qiu WQ
Journal of Alzheimer's disease : JAD 2019;70(4):1025-1040
Journal of Alzheimer's disease : JAD 2019;70(4):1025-1040
Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.
Regalado-Reyes M, Furcila D, Hernández F, Ávila J, DeFelipe J, León-Espinosa G
Journal of Alzheimer's disease : JAD 2019;69(1):277-288
Journal of Alzheimer's disease : JAD 2019;69(1):277-288
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Bullmann T, Feneberg E, Kretzschmann TP, Ogunlade V, Holzer M, Arendt T
Frontiers in neuroanatomy 2019;13:69
Frontiers in neuroanatomy 2019;13:69
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J, NIMA Consortium, Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH
Brain : a journal of neurology 2019 Oct 1;142(10):3243-3264
Brain : a journal of neurology 2019 Oct 1;142(10):3243-3264
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports.
Schwab N, Grenier K, Hazrati LN
Acta neuropathologica communications 2019 Nov 14;7(1):182
Acta neuropathologica communications 2019 Nov 14;7(1):182
N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain.
Schlegel K, Awwad K, Heym RG, Holzinger D, Doell A, Barghorn S, Jahn TR, Klein C, Mordashova Y, Schulz M, Gasparini L
Acta neuropathologica communications 2019 Nov 13;7(1):177
Acta neuropathologica communications 2019 Nov 13;7(1):177
Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Pallas-Bazarra N, Rábano A, Sah N, van Praag H, Giacomini D, Schinder AF, Ávila J, Llorens-Martín M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 17;39(29):5794-5815
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 17;39(29):5794-5815
In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain.
Nam WH, Choi YP
Prion 2019 Jan;13(1):1-12
Prion 2019 Jan;13(1):1-12
Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice.
Belfiore R, Rodin A, Ferreira E, Velazquez R, Branca C, Caccamo A, Oddo S
Aging cell 2019 Feb;18(1):e12873
Aging cell 2019 Feb;18(1):e12873
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R, Crowther RA, Newell KL, Ghetti B, Goedert M, Scheres SHW
Nature 2019 Apr;568(7752):420-423
Nature 2019 Apr;568(7752):420-423
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Romero-Molina C, Navarro V, Sanchez-Varo R, Jimenez S, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Muñoz-Castro C, Gutierrez A, Vitorica J, Vizuete M
Frontiers in cellular neuroscience 2018;12:421
Frontiers in cellular neuroscience 2018;12:421
Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator.
Chatterjee S, Cassel R, Schneider-Anthony A, Merienne K, Cosquer B, Tzeplaeff L, Halder Sinha S, Kumar M, Chaturbedy P, Eswaramoorthy M, Le Gras S, Keime C, Bousiges O, Dutar P, Petsophonsakul P, Rampon C, Cassel JC, Buée L, Blum D, Kundu TK, Boutillier AL
EMBO molecular medicine 2018 Nov;10(11)
EMBO molecular medicine 2018 Nov;10(11)
Galectin-8-mediated selective autophagy protects against seeded tau aggregation.
Falcon B, Noad J, McMahon H, Randow F, Goedert M
The Journal of biological chemistry 2018 Feb 16;293(7):2438-2451
The Journal of biological chemistry 2018 Feb 16;293(7):2438-2451
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Lathuilière A, Valdés P, Papin S, Cacquevel M, Maclachlan C, Knott GW, Muhs A, Paganetti P, Schneider BL
Scientific reports 2017 Oct 19;7(1):13556
Scientific reports 2017 Oct 19;7(1):13556
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Zhang Z, Obianyo O, Dall E, Du Y, Fu H, Liu X, Kang SS, Song M, Yu SP, Cabrele C, Schubert M, Li X, Wang JZ, Brandstetter H, Ye K
Nature communications 2017 Mar 27;8:14740
Nature communications 2017 Mar 27;8:14740
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.
Halliday M, Radford H, Zents KAM, Molloy C, Moreno JA, Verity NC, Smith E, Ortori CA, Barrett DA, Bushell M, Mallucci GR
Brain : a journal of neurology 2017 Jun 1;140(6):1768-1783
Brain : a journal of neurology 2017 Jun 1;140(6):1768-1783
Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation.
Kim E, Sakata K, Liao FF
PLoS genetics 2017 Jul;13(7):e1006849
PLoS genetics 2017 Jul;13(7):e1006849
Cryo-EM structures of tau filaments from Alzheimer's disease.
Fitzpatrick AWP, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SHW
Nature 2017 Jul 13;547(7662):185-190
Nature 2017 Jul 13;547(7662):185-190
HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.
García-Ayllón MS, Botella-López A, Cuchillo-Ibañez I, Rábano A, Andreasen N, Blennow K, Ávila J, Sáez-Valero J
Molecular neurobiology 2017 Jan;54(1):188-199
Molecular neurobiology 2017 Jan;54(1):188-199
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Laurent C, Dorothée G, Hunot S, Martin E, Monnet Y, Duchamp M, Dong Y, Légeron FP, Leboucher A, Burnouf S, Faivre E, Carvalho K, Caillierez R, Zommer N, Demeyer D, Jouy N, Sazdovitch V, Schraen-Maschke S, Delarasse C, Buée L, Blum D
Brain : a journal of neurology 2017 Jan;140(1):184-200
Brain : a journal of neurology 2017 Jan;140(1):184-200
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, Figueroa HY, Goldberg E, Hussaini SA, Duff KE
Neuron 2017 Feb 8;93(3):533-541.e5
Neuron 2017 Feb 8;93(3):533-541.e5
Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.
Rodriguez-Rodriguez P, Sandebring-Matton A, Merino-Serrais P, Parrado-Fernandez C, Rabano A, Winblad B, Ávila J, Ferrer I, Cedazo-Minguez A
Brain : a journal of neurology 2017 Dec 1;140(12):3269-3285
Brain : a journal of neurology 2017 Dec 1;140(12):3269-3285
Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies.
Pisa D, Alonso R, Rábano A, Carrasco L
Frontiers in neuroscience 2016;10:86
Frontiers in neuroscience 2016;10:86
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
Salta E, Sierksma A, Vanden Eynden E, De Strooper B
EMBO molecular medicine 2016 Sep;8(9):1005-18
EMBO molecular medicine 2016 Sep;8(9):1005-18
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Pajares M, Jiménez-Moreno N, García-Yagüe ÁJ, Escoll M, de Ceballos ML, Van Leuven F, Rábano A, Yamamoto M, Rojo AI, Cuadrado A
Autophagy 2016 Oct 2;12(10):1902-1916
Autophagy 2016 Oct 2;12(10):1902-1916
Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.
Kasza Á, Hunya Á, Frank Z, Fülöp F, Török Z, Balogh G, Sántha M, Bálind Á, Bernáth S, Blundell KL, Prodromou C, Horváth I, Zeiler HJ, Hooper PL, Vigh L, Penke B
Journal of Alzheimer's disease : JAD 2016 May 7;53(2):557-71
Journal of Alzheimer's disease : JAD 2016 May 7;53(2):557-71
Tau phosphorylation-associated spine regression does not impair hippocampal-dependent memory in hibernating golden hamsters.
Bullmann T, Seeger G, Stieler J, Hanics J, Reimann K, Kretzschmann TP, Hilbrich I, Holzer M, Alpár A, Arendt T
Hippocampus 2016 Mar;26(3):301-18
Hippocampus 2016 Mar;26(3):301-18
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Gorsky MK, Burnouf S, Dols J, Mandelkow E, Partridge L
Scientific reports 2016 Mar 4;6:22685
Scientific reports 2016 Mar 4;6:22685
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Jiang T, Zhang YD, Chen Q, Gao Q, Zhu XC, Zhou JS, Shi JQ, Lu H, Tan L, Yu JT
Neuropharmacology 2016 Jun;105:196-206
Neuropharmacology 2016 Jun;105:196-206
Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner.
Polanco JC, Scicluna BJ, Hill AF, Götz J
The Journal of biological chemistry 2016 Jun 10;291(24):12445-12466
The Journal of biological chemistry 2016 Jun 10;291(24):12445-12466
Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia.
Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
Brain pathology (Zurich, Switzerland) 2016 Jan;26(1):82-94
Brain pathology (Zurich, Switzerland) 2016 Jan;26(1):82-94
Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice.
Elahi M, Motoi Y, Matsumoto SE, Hasan Z, Ishiguro K, Hattori N
Neuroscience letters 2016 Jan 1;610:207-12
Neuroscience letters 2016 Jan 1;610:207-12
The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments.
Nishikawa T, Takahashi T, Nakamori M, Hosomi N, Maruyama H, Miyazaki Y, Izumi Y, Matsumoto M
Neuropathology and applied neurobiology 2016 Dec;42(7):639-653
Neuropathology and applied neurobiology 2016 Dec;42(7):639-653
Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology.
Ling H, Kovacs GG, Vonsattel JP, Davey K, Mok KY, Hardy J, Morris HR, Warner TT, Holton JL, Revesz T
Brain : a journal of neurology 2016 Dec;139(Pt 12):3237-3252
Brain : a journal of neurology 2016 Dec;139(Pt 12):3237-3252
Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice.
Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, Zahel J, Sanchez-Mendoza E, Wang Y, Hermann DM, Arzberger T, Teuber-Hanselmann S, Keyvani K
Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Dec;12(12):1273-1287
Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Dec;12(12):1273-1287
Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex.
Koukouli F, Rooy M, Maskos U
Aging 2016 Dec 20;8(12):3430-3449
Aging 2016 Dec 20;8(12):3430-3449
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J
Acta neuropathologica communications 2016 Aug 26;4(1):91
Acta neuropathologica communications 2016 Aug 26;4(1):91
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Van der Jeugd A, Vermaercke B, Halliday GM, Staufenbiel M, Götz J
Neurobiology of learning and memory 2016 Apr;130:34-43
Neurobiology of learning and memory 2016 Apr;130:34-43
The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.
Brelstaff J, Ossola B, Neher JJ, Klingstedt T, Nilsson KP, Goedert M, Spillantini MG, Tolkovsky AM
Frontiers in neuroscience 2015;9:184
Frontiers in neuroscience 2015;9:184
The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease.
Hansen HH, Fabricius K, Barkholt P, Niehoff ML, Morley JE, Jelsing J, Pyke C, Knudsen LB, Farr SA, Vrang N
Journal of Alzheimer's disease : JAD 2015;46(4):877-88
Journal of Alzheimer's disease : JAD 2015;46(4):877-88
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Dunn HC, Ager RR, Baglietto-Vargas D, Cheng D, Kitazawa M, Cribbs DH, Medeiros R
Journal of Alzheimer's disease : JAD 2015;43(3):893-903
Journal of Alzheimer's disease : JAD 2015;43(3):893-903
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo.
Violet M, Chauderlier A, Delattre L, Tardivel M, Chouala MS, Sultan A, Marciniak E, Humez S, Binder L, Kayed R, Lefebvre B, Bonnefoy E, Buée L, Galas MC
Neurobiology of disease 2015 Oct;82:540-551
Neurobiology of disease 2015 Oct;82:540-551
Different Brain Regions are Infected with Fungi in Alzheimer's Disease.
Pisa D, Alonso R, Rábano A, Rodal I, Carrasco L
Scientific reports 2015 Oct 15;5:15015
Scientific reports 2015 Oct 15;5:15015
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M
Acta neuropathologica 2015 Nov;130(5):619-31
Acta neuropathologica 2015 Nov;130(5):619-31
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Sepulveda-Diaz JE, Alavi Naini SM, Huynh MB, Ouidja MO, Yanicostas C, Chantepie S, Villares J, Lamari F, Jospin E, van Kuppevelt TH, Mensah-Nyagan AG, Raisman-Vozari R, Soussi-Yanicostas N, Papy-Garcia D
Brain : a journal of neurology 2015 May;138(Pt 5):1339-54
Brain : a journal of neurology 2015 May;138(Pt 5):1339-54
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
Li R, Xu DE, Ma T
Neuroscience 2015 May 21;294:14-20
Neuroscience 2015 May 21;294:14-20
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Song L, Lu SX, Ouyang X, Melchor J, Lee J, Terracina G, Wang X, Hyde L, Hess JF, Parker EM, Zhang L
Molecular neurodegeneration 2015 Mar 26;10:14
Molecular neurodegeneration 2015 Mar 26;10:14
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Ittner A, Bertz J, Suh LS, Stevens CH, Götz J, Ittner LM
Journal of neurochemistry 2015 Jan;132(1):135-45
Journal of neurochemistry 2015 Jan;132(1):135-45
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
Falcon B, Cavallini A, Angers R, Glover S, Murray TK, Barnham L, Jackson S, O'Neill MJ, Isaacs AM, Hutton ML, Szekeres PG, Goedert M, Bose S
The Journal of biological chemistry 2015 Jan 9;290(2):1049-65
The Journal of biological chemistry 2015 Jan 9;290(2):1049-65
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.
Mouton-Liger F, Rebillat AS, Gourmaud S, Paquet C, Leguen A, Dumurgier J, Bernadelli P, Taupin V, Pradier L, Rooney T, Hugon J
Cell death & disease 2015 Jan 15;6(1):e1594
Cell death & disease 2015 Jan 15;6(1):e1594
The domestic cat as a natural animal model of Alzheimer's disease.
Chambers JK, Tokuda T, Uchida K, Ishii R, Tatebe H, Takahashi E, Tomiyama T, Une Y, Nakayama H
Acta neuropathologica communications 2015 Dec 10;3:78
Acta neuropathologica communications 2015 Dec 10;3:78
Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.
Miller N, Feng Z, Edens BM, Yang B, Shi H, Sze CC, Hong BT, Su SC, Cantu JA, Topczewski J, Crawford TO, Ko CP, Sumner CJ, Ma L, Ma YC
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 15;35(15):6038-50
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 15;35(15):6038-50
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
Petry FR, Pelletier J, Bretteville A, Morin F, Calon F, Hébert SS, Whittington RA, Planel E
PloS one 2014;9(5):e94251
PloS one 2014;9(5):e94251
Piericidin A aggravates Tau pathology in P301S transgenic mice.
Höllerhage M, Deck R, De Andrade A, Respondek G, Xu H, Rösler TW, Salama M, Carlsson T, Yamada ES, Gad El Hak SA, Goedert M, Oertel WH, Höglinger GU
PloS one 2014;9(12):e113557
PloS one 2014;9(12):e113557
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Castro-Alvarez JF, Uribe-Arias SA, Kosik KS, Cardona-Gómez GP
Frontiers in aging neuroscience 2014;6:243
Frontiers in aging neuroscience 2014;6:243
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Jiang T, Yu JT, Zhu XC, Zhang QQ, Cao L, Wang HF, Tan MS, Gao Q, Qin H, Zhang YD, Tan L
Neuropharmacology 2014 Oct;85:121-30
Neuropharmacology 2014 Oct;85:121-30
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Oct 8;34(41):13629-43
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Oct 8;34(41):13629-43
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Ohia-Nwoko O, Montazari S, Lau YS, Eriksen JL
Molecular neurodegeneration 2014 Nov 28;9:54
Molecular neurodegeneration 2014 Nov 28;9:54
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
Inoue H, Hiradate Y, Shirakata Y, Kanai K, Kosaka K, Gotoh A, Fukuda Y, Nakai Y, Uchida T, Sato E, Tanemura K
FEBS letters 2014 May 29;588(11):2003-8
FEBS letters 2014 May 29;588(11):2003-8
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Yamada ES, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, Rastetter A, Tarze A, Friguet B, Salama M, Champy P, Oertel WH, Höglinger GU
Experimental neurology 2014 Mar;253:113-25
Experimental neurology 2014 Mar;253:113-25
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, Laferla FM
The American journal of pathology 2014 Mar;184(3):819-26
The American journal of pathology 2014 Mar;184(3):819-26
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Mar 19;34(12):4260-72
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
Stancu IC, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, Haylani LE, Couturier J, Schakman O, Gailly P, Pierrot N, Kienlen-Campard P, Octave JN, Dewachter I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jun;28(6):2620-31
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jun;28(6):2620-31
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Richter M, Mewes A, Fritsch M, Krügel U, Hoffmann R, Singer D
Vaccines 2014 Jul 29;2(3):601-23
Vaccines 2014 Jul 29;2(3):601-23
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.
Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, Carrier S, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Colin M, Buée L
Acta neuropathologica communications 2014 Jan 30;2:14
Acta neuropathologica communications 2014 Jan 30;2:14
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM
Neurobiology of disease 2014 Feb;62:407-15
Neurobiology of disease 2014 Feb;62:407-15
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M, Kappos L, Goedert M, Tolnay M, Winkler DT
PloS one 2013;8(5):e62459
PloS one 2013;8(5):e62459
PINCH in the cellular stress response to tau-hyperphosphorylation.
Ozdemir AY, Rom I, Kovalevich J, Yen W, Adiga R, Dave RS, Langford D
PloS one 2013;8(3):e58232
PloS one 2013;8(3):e58232
Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.
Garringer HJ, Murrell J, Sammeta N, Gnezda A, Ghetti B, Vidal R
PloS one 2013;8(2):e56426
PloS one 2013;8(2):e56426
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.
Zussy C, Brureau A, Keller E, Marchal S, Blayo C, Delair B, Ixart G, Maurice T, Givalois L
PloS one 2013;8(1):e53117
PloS one 2013;8(1):e53117
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Leboucher A, Laurent C, Fernandez-Gomez FJ, Burnouf S, Troquier L, Eddarkaoui S, Demeyer D, Caillierez R, Zommer N, Vallez E, Bantubungi K, Breton C, Pigny P, Buée-Scherrer V, Staels B, Hamdane M, Tailleux A, Buée L, Blum D
Diabetes 2013 May;62(5):1681-8
Diabetes 2013 May;62(5):1681-8
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Köhler C, Dinekov M, Götz J
Neurobiology of aging 2013 May;34(5):1369-79
Neurobiology of aging 2013 May;34(5):1369-79
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
Wu TH, Lu YN, Chuang CL, Wu CL, Chiang AS, Krantz DE, Chang HY
Acta neuropathologica 2013 May;125(5):711-25
Acta neuropathologica 2013 May;125(5):711-25
Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies.
Klingstedt T, Blechschmidt C, Nogalska A, Prokop S, Häggqvist B, Danielsson O, Engel WK, Askanas V, Heppner FL, Nilsson KP
Chembiochem : a European journal of chemical biology 2013 Mar 18;14(5):607-16
Chembiochem : a European journal of chemical biology 2013 Mar 18;14(5):607-16
Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients.
Notter T, Knuesel I
Acta neuropathologica communications 2013 Jun 26;1:27
Acta neuropathologica communications 2013 Jun 26;1:27
Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M
Molecular therapy : the journal of the American Society of Gene Therapy 2013 Jul;21(7):1358-68
Molecular therapy : the journal of the American Society of Gene Therapy 2013 Jul;21(7):1358-68
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, Petrucelli L, Sahara N, Dickson DW, Giasson B, Lewis J
Acta neuropathologica 2013 Jul;126(1):39-50
Acta neuropathologica 2013 Jul;126(1):39-50
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
Alonso E, Vale C, Vieytes MR, Botana LM
ACS chemical neuroscience 2013 Jul 17;4(7):1062-70
ACS chemical neuroscience 2013 Jul 17;4(7):1062-70
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Cancino GI, Miller FD, Kaplan DR
Neurobiology of aging 2013 Feb;34(2):387-99
Neurobiology of aging 2013 Feb;34(2):387-99
NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.
Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, Fernandez-Gomez FJ, Troquier L, Eddarkaoui S, Grosjean ME, Demeyer D, Muhr-Tailleux A, Buisson A, Sergeant N, Hamdane M, Humez S, Popoli P, Buée L, Blum D
Aging cell 2013 Feb;12(1):11-23
Aging cell 2013 Feb;12(1):11-23
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, Herms J
Acta neuropathologica communications 2013 Dec 17;1:82
Acta neuropathologica communications 2013 Dec 17;1:82
Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease.
Lahmy V, Meunier J, Malmström S, Naert G, Givalois L, Kim SH, Villard V, Vamvakides A, Maurice T
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Aug;38(9):1706-23
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Aug;38(9):1706-23
Increased amyloid-β peptide-induced memory deficits in phospholipid transfer protein (PLTP) gene knockout mice.
Desrumaux C, Pisoni A, Meunier J, Deckert V, Athias A, Perrier V, Villard V, Lagrost L, Verdier JM, Maurice T
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Apr;38(5):817-25
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 Apr;38(5):817-25
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J
PloS one 2012;7(12):e53547
PloS one 2012;7(12):e53547
Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats.
Chambers JK, Uchida K, Harada T, Tsuboi M, Sato M, Kubo M, Kawaguchi H, Miyoshi N, Tsujimoto H, Nakayama H
PloS one 2012;7(10):e46452
PloS one 2012;7(10):e46452
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, Maruyama H, Ichikawa T, Obata F
PloS one 2012;7(1):e30834
PloS one 2012;7(1):e30834
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S.
Deramecourt V, Lebert F, Maurage CA, Fernandez-Gomez FJ, Dujardin S, Colin M, Sergeant N, Buée-Scherrer V, Clot F, Ber IL, Brice A, Pasquier F, Buée L
Journal of Alzheimer's disease : JAD 2012;31(4):741-9
Journal of Alzheimer's disease : JAD 2012;31(4):741-9
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Bretteville A, Marcouiller F, Julien C, El Khoury NB, Petry FR, Poitras I, Mouginot D, Lévesque G, Hébert SS, Planel E
Scientific reports 2012;2:480
Scientific reports 2012;2:480
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J, Komatsu M, Abeliovich A
Molecular neurodegeneration 2012 Sep 21;7:48
Molecular neurodegeneration 2012 Sep 21;7:48
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
Mondragón-Rodríguez S, Trillaud-Doppia E, Dudilot A, Bourgeois C, Lauzon M, Leclerc N, Boehm J
The Journal of biological chemistry 2012 Sep 14;287(38):32040-53
The Journal of biological chemistry 2012 Sep 14;287(38):32040-53
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
Collins M, Riascos D, Kovalik T, An J, Krupa K, Krupa K, Hood BL, Conrads TP, Renton AE, Traynor BJ, Bowser R
Acta neuropathologica 2012 Nov;124(5):717-32
Acta neuropathologica 2012 Nov;124(5):717-32
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, Sergeant N, Schraen-Maschke S, Blum D, Buee L
Current Alzheimer research 2012 May;9(4):397-405
Current Alzheimer research 2012 May;9(4):397-405
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, Sergeant N, Schraen-Maschke S, Blum D, Buee L
Current Alzheimer research 2012 May;9(4):397-405
Current Alzheimer research 2012 May;9(4):397-405
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Al-Shemary T
Neurotoxicology 2012 Jun;33(3):370-83
Neurotoxicology 2012 Jun;33(3):370-83
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Fine JM, Baillargeon AM, Renner DB, Hoerster NS, Tokarev J, Colton S, Pelleg A, Andrews A, Sparley KA, Krogh KM, Frey WH, Hanson LR
Experimental brain research 2012 Jun;219(3):381-90
Experimental brain research 2012 Jun;219(3):381-90
First transgenic rat model developing progressive cortical neurofibrillary tangles.
Filipcik P, Zilka N, Bugos O, Kucerak J, Koson P, Novak P, Novak M
Neurobiology of aging 2012 Jul;33(7):1448-56
Neurobiology of aging 2012 Jul;33(7):1448-56
The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.
Vidal R, Sammeta N, Garringer HJ, Sambamurti K, Miravalle L, Lamb BT, Ghetti B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jul;26(7):2899-910
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jul;26(7):2899-910
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice.
Krstic D, Madhusudan A, Doehner J, Vogel P, Notter T, Imhof C, Manalastas A, Hilfiker M, Pfister S, Schwerdel C, Riether C, Meyer U, Knuesel I
Journal of neuroinflammation 2012 Jul 2;9:151
Journal of neuroinflammation 2012 Jul 2;9:151
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Rahman A, Khan KM, Al-Khaledi G, Khan I, Attur S
Acta biologica Hungarica 2012 Dec;63(4):411-25
Acta biologica Hungarica 2012 Dec;63(4):411-25
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
Nijholt DA, van Haastert ES, Rozemuller AJ, Scheper W, Hoozemans JJ
The Journal of pathology 2012 Apr;226(5):693-702
The Journal of pathology 2012 Apr;226(5):693-702
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.
Ohmi K, Zhao HZ, Neufeld EF
PloS one 2011;6(11):e27461
PloS one 2011;6(11):e27461
E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment.
Emmer KL, Waxman EA, Covy JP, Giasson BI
The Journal of biological chemistry 2011 Oct 7;286(40):35104-18
The Journal of biological chemistry 2011 Oct 7;286(40):35104-18
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Koike MA, Garcia FG, Kitazawa M, Green KN, Laferla FM
Neuroscience letters 2011 May 9;495(1):55-9
Neuroscience letters 2011 May 9;495(1):55-9
Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.
Kudo LC, Parfenova L, Ren G, Vi N, Hui M, Ma Z, Lau K, Gray M, Bardag-Gorce F, Wiedau-Pazos M, Hui KS, Karsten SL
Human molecular genetics 2011 May 1;20(9):1820-33
Human molecular genetics 2011 May 1;20(9):1820-33
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean ME, Humez S, Balschun D, Blum D, Buée L, D'Hooge R
Neurobiology of learning and memory 2011 Mar;95(3):296-304
Neurobiology of learning and memory 2011 Mar;95(3):296-304
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):189-200
Brain pathology (Zurich, Switzerland) 2011 Mar;21(2):189-200
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
Tran HT, LaFerla FM, Holtzman DM, Brody DL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jun 29;31(26):9513-25
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
Stieler JT, Bullmann T, Kohl F, Tøien Ø, Brückner MK, Härtig W, Barnes BM, Arendt T
PloS one 2011 Jan 18;6(1):e14530
PloS one 2011 Jan 18;6(1):e14530
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Fonseca MI, Chu SH, Berci AM, Benoit ME, Peters DG, Kimura Y, Tenner AJ
Journal of neuroinflammation 2011 Jan 15;8(1):4
Journal of neuroinflammation 2011 Jan 15;8(1):4
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM
Neurochemistry international 2011 Dec;59(7):1056-65
Neurochemistry international 2011 Dec;59(7):1056-65
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6539-49
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Belarbi K, Burnouf S, Fernandez-Gomez FJ, Laurent C, Lestavel S, Figeac M, Sultan A, Troquier L, Leboucher A, Caillierez R, Grosjean ME, Demeyer D, Obriot H, Brion I, Barbot B, Galas MC, Staels B, Humez S, Sergeant N, Schraen-Maschke S, Muhr-Tailleux A, Hamdane M, Buée L, Blum D
Neurobiology of disease 2011 Aug;43(2):486-94
Neurobiology of disease 2011 Aug;43(2):486-94
A peculiar constellation of tau pathology defines a subset of dementia in the elderly.
Kovacs GG, Molnár K, László L, Ströbel T, Botond G, Hönigschnabl S, Reiner-Concin A, Palkovits M, Fischer P, Budka H
Acta neuropathologica 2011 Aug;122(2):205-22
Acta neuropathologica 2011 Aug;122(2):205-22
LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.
Lin CH, Tsai PI, Wu RM, Chien CT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Sep 29;30(39):13138-49
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Sep 29;30(39):13138-49
The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau.
Bertrand J, Sénéchal P, Zummo-Soucy M, Plouffe V, Leclerc N
Journal of neurochemistry 2010 Sep 1;114(5):1353-67
Journal of neurochemistry 2010 Sep 1;114(5):1353-67
Axonal inclusions in spinocerebellar ataxia type 3.
Seidel K, den Dunnen WF, Schultz C, Paulson H, Frank S, de Vos RA, Brunt ER, Deller T, Kampinga HH, Rüb U
Acta neuropathologica 2010 Oct;120(4):449-60
Acta neuropathologica 2010 Oct;120(4):449-60
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Giménez-Llort L, Botana LM
Cellular and molecular neurobiology 2010 May;30(4):577-90
Cellular and molecular neurobiology 2010 May;30(4):577-90
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Koike MA, Green KN, Blurton-Jones M, Laferla FM
The American journal of pathology 2010 Jul;177(1):300-10
The American journal of pathology 2010 Jul;177(1):300-10
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM
The American journal of pathology 2010 Feb;176(2):870-80
The American journal of pathology 2010 Feb;176(2):870-80
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.
Colodner KJ, Feany MB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 1;30(48):16102-13
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 1;30(48):16102-13
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
Capsoni S, Covaceuszach S, Ugolini G, Spirito F, Vignone D, Stefanini B, Amato G, Cattaneo A
Journal of Alzheimer's disease : JAD 2009;16(2):371-88
Journal of Alzheimer's disease : JAD 2009;16(2):371-88
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
Nogalska A, Terracciano C, D'Agostino C, King Engel W, Askanas V
Acta neuropathologica 2009 Sep;118(3):407-13
Acta neuropathologica 2009 Sep;118(3):407-13
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
van Eersel J, Bi M, Ke YD, Hodges JR, Xuereb JH, Gregory GC, Halliday GM, Götz J, Kril JJ, Ittner LM
Journal of neural transmission (Vienna, Austria : 1996) 2009 Oct;116(10):1243-51
Journal of neural transmission (Vienna, Austria : 1996) 2009 Oct;116(10):1243-51
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Ohmi K, Kudo LC, Ryazantsev S, Zhao HZ, Karsten SL, Neufeld EF
Proceedings of the National Academy of Sciences of the United States of America 2009 May 19;106(20):8332-7
Proceedings of the National Academy of Sciences of the United States of America 2009 May 19;106(20):8332-7
Transmission and spreading of tauopathy in transgenic mouse brain.
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M
Nature cell biology 2009 Jul;11(7):909-13
Nature cell biology 2009 Jul;11(7):909-13
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
Ittner LM, Ke YD, Götz J
The Journal of biological chemistry 2009 Jul 31;284(31):20909-16
The Journal of biological chemistry 2009 Jul 31;284(31):20909-16
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
Rahman A, Ting K, Cullen KM, Braidy N, Brew BJ, Guillemin GJ
PloS one 2009 Jul 22;4(7):e6344
PloS one 2009 Jul 22;4(7):e6344
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Wiedau-Pazos M, Wong E, Solomon E, Alarcon M, Geschwind DH
Neurobiology of aging 2009 Jan;30(1):14-21
Neurobiology of aging 2009 Jan;30(1):14-21
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Chatterjee S, Sang TK, Lawless GM, Jackson GR
Human molecular genetics 2009 Jan 1;18(1):164-77
Human molecular genetics 2009 Jan 1;18(1):164-77
Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes.
Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH
The American journal of pathology 2008 Jun;172(6):1683-92
The American journal of pathology 2008 Jun;172(6):1683-92
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca FL, Catania M, Di Fede G, Mangieri M, Giaccone G, Croci D, Tagliavini F
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Rossi G, Dalprà L, Crosti F, Lissoni S, Sciacca FL, Catania M, Di Fede G, Mangieri M, Giaccone G, Croci D, Tagliavini F
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
Cell cycle (Georgetown, Tex.) 2008 Jun 15;7(12):1788-94
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles.
Caccamo A, Oddo S, Tran LX, LaFerla FM
The American journal of pathology 2007 May;170(5):1669-75
The American journal of pathology 2007 May;170(5):1669-75
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G
Proceedings of the National Academy of Sciences of the United States of America 2007 May 29;104(22):9511-6
Proceedings of the National Academy of Sciences of the United States of America 2007 May 29;104(22):9511-6
Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.
Steinhilb ML, Dias-Santagata D, Fulga TA, Felch DL, Feany MB
Molecular biology of the cell 2007 Dec;18(12):5060-8
Molecular biology of the cell 2007 Dec;18(12):5060-8
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr 18;27(16):4385-95
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Apr 18;27(16):4385-95
Cell type-specific processing of human Tau proteins in Drosophila.
Grammenoudi S, Kosmidis S, Skoulakis EM
FEBS letters 2006 Aug 21;580(19):4602-6
FEBS letters 2006 Aug 21;580(19):4602-6
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.
Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y
The Journal of biological chemistry 2004 Oct 22;279(43):44795-801
The Journal of biological chemistry 2004 Oct 22;279(43):44795-801
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Mar 10;24(10):2527-34
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Mar 10;24(10):2527-34
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
Klein RL, Lin WL, Dickson DW, Lewis J, Hutton M, Duff K, Meyer EM, King MA
The American journal of pathology 2004 Jan;164(1):347-53
The American journal of pathology 2004 Jan;164(1):347-53
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10966-71
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10966-71
Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.
DeTure M, Ko LW, Easson C, Yen SH
The American journal of pathology 2002 Nov;161(5):1711-22
The American journal of pathology 2002 Nov;161(5):1711-22
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.
Sahara N, Lewis J, DeTure M, McGowan E, Dickson DW, Hutton M, Yen SH
Journal of neurochemistry 2002 Dec;83(6):1498-508
Journal of neurochemistry 2002 Dec;83(6):1498-508
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.
Sahara N, Lewis J, DeTure M, McGowan E, Dickson DW, Hutton M, Yen SH
Journal of neurochemistry 2002 Dec;83(6):1498-508
Journal of neurochemistry 2002 Dec;83(6):1498-508
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Yoshida H, Goedert M
Biochemistry 2002 Dec 24;41(51):15203-11
Biochemistry 2002 Dec 24;41(51):15203-11
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Yoshida H, Goedert M
Biochemistry 2002 Dec 24;41(51):15203-11
Biochemistry 2002 Dec 24;41(51):15203-11
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.
Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW
Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 17;98(15):8838-43
Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 17;98(15):8838-43
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein.
Goedert M, Jakes R, Crowther RA, Cohen P, Vanmechelen E, Vandermeeren M, Cras P
The Biochemical journal 1994 Aug 1;301 ( Pt 3):871-7
The Biochemical journal 1994 Aug 1;301 ( Pt 3):871-7
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