BS8266

antibody from Bioworld Technology, Inc
Targeting: EIF3I eIF3-beta, eIF3-p36, EIF3S2, TRIP-1
Provider product page for BS8266
Western blot
Immunohistochemistry

Antibody data

Product number
BS8266 - Provider product page
Provider
Bioworld Technology, Inc
Product name
EIF3I polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human EIF3I.
Description
The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3Ï«, eIF3ÉÇ, eIF3Ñ´, eIF3ÎÛ, eIF3»Ò, eIF3š÷, eIF3IJ and eIF3šø, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-MettRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
EIF3I protein structure - BS8266 shown in red.