Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations [0]
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- Product number
- ABIN350048 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN350048, RRID:AB_10779646
- Product name
- anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (Extracellular Domain) antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide from the extracellular domain of rat amiloride sensitive cation channel 2, neuronal (ACCN2, ASIC1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse and shares 96% identity with
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- Extracellular Domain
- Vial size
- 100 μL
- Storage
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
- Handling
- Avoid freeze and thaw cycles.
Submitted references The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1.
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).
Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b.
Cloning and functional expression of ASIC-beta2, a splice variant of ASIC-beta.
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.
A sensory neuron-specific, proton-gated ion channel.
The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.
A proton-gated cation channel involved in acid-sensing.
Coric T, Zhang P, Todorovic N, Canessa CM
The Journal of biological chemistry 2003 Nov 14;278(46):45240-7
The Journal of biological chemistry 2003 Nov 14;278(46):45240-7
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).
Babini E, Paukert M, Geisler HS, Grunder S
The Journal of biological chemistry 2002 Nov 1;277(44):41597-603
The Journal of biological chemistry 2002 Nov 1;277(44):41597-603
Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b.
Bässler EL, Ngo-Anh TJ, Geisler HS, Ruppersberg JP, Gründer S
The Journal of biological chemistry 2001 Sep 7;276(36):33782-7
The Journal of biological chemistry 2001 Sep 7;276(36):33782-7
Cloning and functional expression of ASIC-beta2, a splice variant of ASIC-beta.
Ugawa S, Ueda T, Takahashi E, Hirabayashi Y, Yoneda T, Komai S, Shimada S
Neuroreport 2001 Sep 17;12(13):2865-9
Neuroreport 2001 Sep 17;12(13):2865-9
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Voilley N, de Weille J, Mamet J, Lazdunski M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Oct 15;21(20):8026-33
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Oct 15;21(20):8026-33
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
Escoubas P, De Weille JR, Lecoq A, Diochot S, Waldmann R, Champigny G, Moinier D, Ménez A, Lazdunski M
The Journal of biological chemistry 2000 Aug 18;275(33):25116-21
The Journal of biological chemistry 2000 Aug 18;275(33):25116-21
Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.
Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ
Neuron 2000 Apr;26(1):133-41
Neuron 2000 Apr;26(1):133-41
A sensory neuron-specific, proton-gated ion channel.
Chen CC, England S, Akopian AN, Wood JN
Proceedings of the National Academy of Sciences of the United States of America 1998 Aug 18;95(17):10240-5
Proceedings of the National Academy of Sciences of the United States of America 1998 Aug 18;95(17):10240-5
The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.
Bassilana F, Champigny G, Waldmann R, de Weille JR, Heurteaux C, Lazdunski M
The Journal of biological chemistry 1997 Nov 14;272(46):28819-22
The Journal of biological chemistry 1997 Nov 14;272(46):28819-22
A proton-gated cation channel involved in acid-sensing.
Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M
Nature 1997 Mar 13;386(6621):173-7
Nature 1997 Mar 13;386(6621):173-7
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