636102

antibody from BioLegend

Targeting: AURKB Aik2, AIM-1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

636102

Provider

BioLegend

Proper citation

BioLegend Cat#636102, RRID:AB_2274484

Product name

Purified anti-Aurora B Phospho (Thr232)

Antibody type

Polyclonal

Antigen

Modified peptide

Description

Aurora B belongs to Serine/threonine kinase family, Aurora subfamily. Predicted molecular weight 39 kD. This kinase is highly expressed in thymus and many cancers and is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Aurora B is expressed during S and G2/M phase and is up regulated in cancer cells during M phase. Aurora B localizes to centromeres in early mitosisand then the spindle midzone in anaphase and is required for histoneH3 phosphorylation, chromosome alignment, centrosome maturation, activation of the spindle assembly checkpoint and cytokinesis. The Poly6361 antibody recognizes human phospho-Aurora B (Thr232) and has been shown to be useful for immunoflorence staining.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 µl

Storage

Upon receipt, store frozen at -20°C.

References

Submitted references

Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.

Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA, Kleer CG
Cancer research 2011 Mar 15;71(6):2360-70

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Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development.

Luciano AM, Lodde V, Franciosi F, Ceciliani F, Peluso JJ
Reproduction (Cambridge, England) 2010 Nov;140(5):663-72