Tissue expression
Cell line expression
Protein structure
MAP3K3
Mitogen-activated protein kinase kinase kinase 3MAPKKK3, MEKK3
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Novus Biologicals | NBP2-67832 | Monoclonal |
WB
ICC
IP
IHC
FC
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Proteintech Group | 21072-1-AP | 1 references | Polyclonal |
WB
EL
IP
IHC |
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Boster Biological Technology | A03586 | Polyclonal |
WB
ICC
IP
IHC
FC
|
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Invitrogen Antibodies | BSM-52709R | Monoclonal |
WB
ICC
IHC
FC |
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HUABIO Research | ET1612-98 | Monoclonal |
WB
ICC
IP
IHC
FC
|
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