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- References [8]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 18590-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18590-1-AP, RRID:AB_2168573
- Product name
- iASPP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated iASPP antibody (Cat. #18590-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
Apigenin Alleviates Zearalenone-Induced Oxidative Stress and Apoptosis in Swine Testis Cells Through the Wnt Signaling Pathway.
High iASPP (PPP1R13L) expression is an independent predictor of adverse clinical outcome in acute myeloid leukemia (AML).
Inhibitor of apoptosis stimulating protein of p53 protects against MPP(+)-induced neurotoxicity of dopaminergic neurons.
Upregulation of iASPP ameliorates hypoxia/reoxygenation-induced apoptosis and oxidative stress in cardiomyocytes by upregulating Nrf2 signaling.
iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis.
iASPP contributes to cell cortex rigidity, mitotic cell rounding, and spindle positioning.
iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation.
Shan M, Xiao M, Zhang L, Wang S, Wu J, Cao K, Li Y, Zhang G, Xie J, Lu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
Apigenin Alleviates Zearalenone-Induced Oxidative Stress and Apoptosis in Swine Testis Cells Through the Wnt Signaling Pathway.
Guo C, Zhang Y, Wang Y, Sun Y, Ning H, Gao J, Guo F, Ji P, Zhang L, Liu G, Wang B
Antioxidants (Basel, Switzerland) 2025 Dec 29;15(1)
Antioxidants (Basel, Switzerland) 2025 Dec 29;15(1)
High iASPP (PPP1R13L) expression is an independent predictor of adverse clinical outcome in acute myeloid leukemia (AML).
Bajrami Saipi M, Ruiba A, Schittenhelm MM, Blumenstock G, Győrffy B, Fazio S, Hafner M, Ahrens AL, Aldinger L, Aellig V, Kavelaars FG, Nombela-Arrieta C, Fend F, Valk PJM, Christoph D, Kampa-Schittenhelm KM
Cell death & disease 2024 Nov 30;15(11):869
Cell death & disease 2024 Nov 30;15(11):869
Inhibitor of apoptosis stimulating protein of p53 protects against MPP(+)-induced neurotoxicity of dopaminergic neurons.
Chen L, Duan F, Ge F, Tian L, Li Y, Li Y, Zhu Q, Zhou Q, Lin H
Metabolic brain disease 2024 Jun;39(5):871-884
Metabolic brain disease 2024 Jun;39(5):871-884
Upregulation of iASPP ameliorates hypoxia/reoxygenation-induced apoptosis and oxidative stress in cardiomyocytes by upregulating Nrf2 signaling.
Bai B, Zeng G, Chen R, Ai Y, Qiang H
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22686
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22686
iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis.
Yagudin T, Zhao Y, Gao H, Zhang Y, Yang Y, Zhang X, Ma W, Daba TM, Ishmetov V, Kang K, Yang B, Pan Z
Acta biochimica et biophysica Sinica 2021 Jan 12;53(1):102-111
Acta biochimica et biophysica Sinica 2021 Jan 12;53(1):102-111
iASPP contributes to cell cortex rigidity, mitotic cell rounding, and spindle positioning.
Mangon A, Salaün D, Bouali ML, Kuzmić M, Quitard S, Thuault S, Isnardon D, Audebert S, Puech PH, Verdier-Pinard P, Badache A
The Journal of cell biology 2021 Dec 6;220(12)
The Journal of cell biology 2021 Dec 6;220(12)
iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation.
Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao SM, Li Y, Zhang P, Wang C
Cell death & disease 2018 May 1;9(5):528
Cell death & disease 2018 May 1;9(5):528
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 18590-1-AP(PPP1R13L antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using PPP1R13L antibody 18590-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 18590-1-AP(PPP1R13L antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 18590-1-AP(PPP1R13L antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
