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- Antigen structure
- References [238]
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- Product number
- 10829-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10829-1-AP, RRID:AB_2232989
- Product name
- HMGB1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HMGB1 antibody (Cat. #10829-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references HMGB1 Modulates High Glucose-Induced Erroneous Differentiation of Tendon Stem/Progenitor Cells through RAGE/β-Catenin Pathway.
N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats.
Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death.
Inhibition of sugar-binding activity of Galectins-8 by thiogalactoside (TDG) attenuates secondary brain damage and improves long-term prognosis following intracerebral hemorrhage.
Potent induction of antitumor immunity by combining cryo-thermal ablation with immune checkpoint inhibitors in hepatocellular carcinoma.
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development.
Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair.
Electroacupuncture Inhibits Neuroinflammation Induced by Astrocytic Necroptosis Through RIP1/MLKL/TLR4 Pathway in a Mouse Model of Spinal Cord Injury.
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced liver injury.
Positron emission tomography guided synergistic treatment of melanoma using multifunctional zirconium-hematoporphyrin nanosonosensitizers.
Elucidation of Spatial Cooperativity in Chemo-Immunotherapy by a Sequential Dual-pH-Responsive Drug Delivery System.
Cu(2)WS(4)-PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno-Radiotherapy by Inducing Ferroptosis.
Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer.
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death.
IFITM3 overexpression reverses insufficient healing benefits of small extracellular vesicles from high-fat-diet BMSCs in sepsis via the HMGB1 pathway.
Tumorous IRE1α facilitates CD8(+)T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma.
Self-heating mitochondrion-induced free radical blast for immunogenic cell death stimulation and HCC immunotherapy.
Copper-coordinated nanoassemblies based on photosensitizer-chemo prodrugs and checkpoint inhibitors for enhanced apoptosis-cuproptosis and immunotherapy.
Cathepsin B-Responsive Programmed Brain Targeted Delivery System for Chemo-Immunotherapy Combination Therapy of Glioblastoma.
Proton-Gradient-Driven Porphyrin-Based Liposome Remote-Loaded with Imiquimod as In Situ Nanoadjuvants for Synergistically Augmented Tumor Photoimmunotherapy.
Design, synthesis, and antitumor mechanism investigation of iridium(III) complexes conjugated with ibuprofen.
Exosomes derived from bone marrow mesenchymal stem cells alleviate biliary ischemia reperfusion injury in fatty liver transplantation by inhibiting ferroptosis.
SYVN1 modulates papillary thyroid carcinoma progression by destabilizing HMGB1.
Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis.
Identification of a novel FOXO3 agonist that protects against alcohol induced liver injury.
Increased serum levels of high-mobility group box 1 protein and the location characteristics in the patients of intracranial aneurysms.
MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway.
ESE-1 mediates lipopolysaccharide-induced BV2 cell inflammation via upregulation of HMGB1 expression.
Radioimmunotherapy Targeting B7-H3 in situ glioma models enhanced antitumor efficacy by Reconstructing the tumor microenvironment.
Multifunctional Nanoplatform-Mediated Chemo-Photothermal Therapy Combines Immunogenic Cell Death with Checkpoint Blockade to Combat Triple-Negative Breast Cancer and Distant Metastasis.
A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.
San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2 signalling pathway.
MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling.
Autophagy-amplifying nanoparticles evoke immunogenic cell death combined with anti-PD-1/PD-L1 for residual tumors immunotherapy after RFA.
Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma.
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.
Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated metastasis and cisplatin resistance in cervical cancer.
Activation of autophagy by in situ Zn(2+) chelation reaction for enhanced tumor chemoimmunotherapy.
Keratinocyte derived HMGB1 aggravates psoriasis dermatitis via facilitating inflammatory polarization of macrophages and hyperproliferation of keratinocyte.
Analysis of CRSsNP Proteome Using a Highly Multiplexed Approach in Nasal Mucus.
Chemical characterization of the polyphenolic rich fraction of Thunbergia erecta and its therapeutic potential against doxorubicin and cyclophosphamide-induced cognitive impairment in rats.
Neutrophil extracellular traps contribute to coagulopathy after traumatic brain injury.
Dapagliflozin ameliorates diabetic renal injury through suppressing the self-perpetuating cycle of inflammation mediated by HMGB1 feedback signaling in the kidney.
HMGB1 coordinates with Brahma-related gene 1 to promote epithelial-mesenchymal transition via the PI3K/Akt/mTOR pathway in BEAS-2B cells.
Atrazine induces phagocytotic dysfunction of microglia depends on nucleocytoplasmic translocation of acetylated HMGB1.
Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway.
NSAID-Au(I) Complexes Induce ROS-Driven DAMPs and Interpose Inflammation to Stimulate the Immune Response against Ovarian Cancer.
ROS-responsive self-activatable photosensitizing agent for photodynamic-immunotherapy of cancer.
Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway.
Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1.
Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus.
Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway.
Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.
Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis.
Biomimetic Prussian blue nanocomplexes for chemo-photothermal treatment of triple-negative breast cancer by enhancing ICD.
Prolonged Antibiotic Use in a Preclinical Model of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-like Pathology via Increased micro-RNA 21-Induced PTEN Inhibition That Is Correlated with Low Host Lachnospiraceae Abundance.
Nanointegrative In Situ Reprogramming of Tumor-Intrinsic Lipid Droplet Biogenesis for Low-Dose Radiation-Activated Ferroptosis Immunotherapy.
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes.
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation.
Hypermethylation of RNF125 promotes autophagy-induced oxidative stress in asthma by increasing HMGB1 stability.
An artificial intelligence network-guided signature for predicting outcome and immunotherapy response in lung adenocarcinoma patients based on 26 machine learning algorithms.
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Potential influences of expression levels of MFGE8 and HMGB1 on the intestinal mucosal barrier function and inflammatory response after blunt abdominal injury in rats.
miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2.
The lncRNA SEMA3B-AS1/HMGB1/FBXW7 Axis Mediates the Peritoneal Metastasis of Gastric Cancer by Regulating BGN Protein Ubiquitination.
PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cells.
Aggravated renal fibrosis is positively associated with the activation of HMGB1-TLR2/4 signaling in STZ-induced diabetic mice.
HMGB1 overexpression promotes a malignant phenotype and radioresistance in ESCC.
Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling.
Acteoside attenuates RSV-induced lung injury by suppressing necroptosis and regulating metabolism.
Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier-Free Nanoassembly of Fluorinated Prodrug and siRNA.
The HN1/HMGB1 axis promotes the proliferation and metastasis of hepatocellular carcinoma and attenuates the chemosensitivity to oxaliplatin.
One night of sleep deprivation induces release of small extracellular vesicles into circulation and promotes platelet activation by small EVs.
Highly effective identification of drug targets at the proteome level by pH-dependent protein precipitation.
Enhanced Immunotherapy Based on Combining the Pro-phagocytosis and Anti-phagocytosis Checkpoint Blockade for Tumor Eradication.
ENSMUST00000147869 regulates proliferation and fibrosis of mesangial cells in diabetic nephropathy by interacting with Hspa9.
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation.
Low-Dose Propranolol Prevents Functional Decline in Catecholamine-Induced Acute Heart Failure in Rats.
Contribution of Necroptosis to Myofiber Death in Idiopathic Inflammatory Myopathies.
Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy.
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor.
Corilagin induces apoptosis and inhibits autophagy of HL‑60 cells by regulating miR‑451/HMGB1 axis.
MFGE8 decreased neuronal apoptosis and neuroinflammation to ameliorate early brain injury induced by subarachnoid hemorrhage through the inhibition of HMGB1.
Epithelial microRNA-30a-3p targets RUNX2/HMGB1 axis to suppress airway eosinophilic inflammation in asthma.
Protective Effect of MFG-E8 on Necroptosis-Induced Intestinal Inflammation and Enteroendocrine Cell Function in Diabetes.
Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy.
Anlotinib combined with temozolomide suppresses glioblastoma growth via mediation of JAK2/STAT3 signaling pathway.
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway.
Metformin attenuated sepsis-associated liver injury and inflammatory response in aged mice.
Regorafenib and reactive metabolite of sunitinib activate inflammasomes: Implications for multi tyrosine kinase inhibitor-Iiduced immune related adverse events.
Acteoside alleviates dextran sulphate sodium‑induced ulcerative colitis via regulation of the HO‑1/HMGB1 signaling pathway.
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism.
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease.
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.
Inhibition of Neutrophil Extracellular Traps Formation by Cl-Amidine Alleviates Lipopolysaccharide-Induced Endometritis and Uterine Tissue Damage.
Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs.
TRAIL-modified, doxorubicin-embedded periodic mesoporous organosilica nanoparticles for targeted drug delivery and efficient antitumor immunotherapy.
Fe(III)-Chelated Polydopamine Nanoparticles for Synergistic Tumor Therapies of Enhanced Photothermal Ablation and Antitumor Immune Activation.
Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Macrophage contributes to radiation-induced anti-tumor abscopal effect on transplanted breast cancer by HMGB1/TNF-α signaling factors.
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood-brain barrier during kainic acid-induced brain damage.
Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling.
Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.
HMGB1 Mediated Inflammation and Autophagy Contribute to Endometriosis.
Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Methionine enkephalin (MENK) suppresses lung cancer by regulating the Bcl-2/Bax/caspase-3 signaling pathway and enhancing natural killer cell-driven tumor immunity.
Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent.
An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy.
Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy.
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer.
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation.
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis.
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events.
miR-548b Suppresses Melanoma Cell Growth, Migration, and Invasion by Negatively Regulating Its Target Gene HMGB1.
Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target.
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Organic Near-Infrared-II Nanophotosensitizer for Safe Cancer Phototheranostics and Improving Immune Microenvironment against Metastatic Tumor.
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Neonatal Streptococcus Pneumoniae pneumonia induces airway SMMHC expression through HMGB1/TLR4/ERK.
miR-142-3p and HMGB1 Are Negatively Regulated in Proliferation, Apoptosis, Migration, and Autophagy of Cartilage Endplate Cells.
CCN2 Aggravates the Immediate Oxidative Stress-DNA Damage Response following Renal Ischemia-Reperfusion Injury.
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal.
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Rosmarinic acid alleviates di-2-ethylhexyl phthalate (DEHP) -induced thyroid dysfunction via multiple inflammasomes activation.
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury.
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement.
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Self-enforcing HMGB1/NF-κB/HIF-1α Feedback Loop Promotes Cisplatin Resistance in Hepatocellular Carcinoma Cells.
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury.
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury.
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis.
Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury.
Impact of perioperative high mobility group box chromosomal protein 1 expression on long-term outcomes in patients with esophageal squamous cell carcinoma.
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Upregulation of microRNA-204 improves insulin resistance of polycystic ovarian syndrome via inhibition of HMGB1 and the inactivation of the TLR4/NF-κB pathway.
Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model.
Pannexin1 Channel Inhibitor ((10)panx) Protects Against Transient Focal Cerebral Ischemic Injury by Inhibiting RIP3 Expression and Inflammatory Response in Rats.
NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity.
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages.
Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes.
Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons.
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
circ_0007385 served as competing endogenous RNA for miR-519d-3p to suppress malignant behaviors and cisplatin resistance of non-small cell lung cancer cells.
Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway.
Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes.
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling.
Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways.
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice.
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition.
Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis.
Neuroprotective Effect of Dioscin on the Aging Brain.
Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis.
Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps.
Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice.
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.
Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain.
HMGB1 is mechanistically essential in the development of experimental pulmonary hypertension.
XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy.
Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.
Platelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability.
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent.
The multidisciplinary support in preventing alcohol relapse after liver transplantation: A single-center experience.
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.
Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer.
Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing high mobility group box 1 and inflammatory cytokines.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization.
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.
Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke.
Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.
Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes.
Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.
The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Pathophysiology of Endometriosis: Role of High Mobility Group Box-1 and Toll-Like Receptor 4 Developing Inflammation in Endometrium.
Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae.
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury.
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Potent effects of dioscin against obesity in mice.
Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury.
Potent effects of dioscin against liver fibrosis.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
miR-200c inhibits metastasis of breast cancer cells by targeting HMGB1.
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.
Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells.
RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer.
RAGE signaling significantly impacts tumorigenesis and hepatic tumor growth in murine models of colorectal carcinoma.
The C/EBPbeta isoform, liver-inhibitory protein (LIP), induces autophagy in breast cancer cell lines.
HMGB1 activates nuclear factor-κB signaling by RAGE and increases the production of TNF-α in human umbilical vein endothelial cells.
Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma.
Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.
Lu P, Dai G, Shi L, Li Y, Zhang M, Wang H, Rui Y
Stem cells international 2024;2024:2335270
Stem cells international 2024;2024:2335270
N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats.
Zhao YZ, Zhang XN, Yin Y, Xiao PL, Gao M, Zhang LM, Zhou SH, Yu SN, Wang XL, Zhao YS
International journal of ophthalmology 2024;17(2):228-238
International journal of ophthalmology 2024;17(2):228-238
Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death.
Liang J, Tian X, Zhou M, Yan F, Fan J, Qin Y, Chen B, Huo X, Yu Z, Tian Y, Deng S, Peng Y, Wang Y, Liu B, Ma X
Biomaterials 2024 Sep;309:122608
Biomaterials 2024 Sep;309:122608
Inhibition of sugar-binding activity of Galectins-8 by thiogalactoside (TDG) attenuates secondary brain damage and improves long-term prognosis following intracerebral hemorrhage.
Song J, Bai H, Chen S, Xing Y, Lou J
Heliyon 2024 May 15;10(9):e30422
Heliyon 2024 May 15;10(9):e30422
Potent induction of antitumor immunity by combining cryo-thermal ablation with immune checkpoint inhibitors in hepatocellular carcinoma.
Qian L, Xie L, Zhu Y, Huang C, Meng Z
Liver international : official journal of the International Association for the Study of the Liver 2024 Mar;44(3):723-737
Liver international : official journal of the International Association for the Study of the Liver 2024 Mar;44(3):723-737
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development.
Lv L, Wei Q, Zhang J, Dong Y, Shan Z, Chang N, Zhao Y, Bian P, Yi Q
Cellular & molecular biology letters 2024 Mar 19;29(1):39
Cellular & molecular biology letters 2024 Mar 19;29(1):39
Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair.
Li J, Liu T, Tang N, Lin S, Zhang F, Yuan W, Zhang T, Deng SH, Wu DM, Xu Y
Heliyon 2024 Mar 15;10(5):e26975
Heliyon 2024 Mar 15;10(5):e26975
Electroacupuncture Inhibits Neuroinflammation Induced by Astrocytic Necroptosis Through RIP1/MLKL/TLR4 Pathway in a Mouse Model of Spinal Cord Injury.
Zhao H, Zong X, Li L, Li N, Liu C, Zhang W, Li J, Yang C, Huang S
Molecular neurobiology 2024 Jun;61(6):3258-3271
Molecular neurobiology 2024 Jun;61(6):3258-3271
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced liver injury.
Tanaka S, Noda T, Urashima K, Ijiri Y, Kohda Y, Kato R
Journal of applied toxicology : JAT 2024 Jun;44(6):846-852
Journal of applied toxicology : JAT 2024 Jun;44(6):846-852
Positron emission tomography guided synergistic treatment of melanoma using multifunctional zirconium-hematoporphyrin nanosonosensitizers.
Jiao X, Li X, Du Y, Cong Y, Yang S, Chen D, Zhang T, Feng M, Hong H
Journal of controlled release : official journal of the Controlled Release Society 2024 Jun;370:95-109
Journal of controlled release : official journal of the Controlled Release Society 2024 Jun;370:95-109
Elucidation of Spatial Cooperativity in Chemo-Immunotherapy by a Sequential Dual-pH-Responsive Drug Delivery System.
Wang S, Liu L, Tian L, Xu P, Li S, Hu L, Xia Y, Ding Y, Wang J, Li S
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(26):e2403296
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(26):e2403296
Cu(2)WS(4)-PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno-Radiotherapy by Inducing Ferroptosis.
Fu S, Li Y, Shen L, Chen Y, Lu J, Ran Y, Zhao Y, Tang H, Tan L, Lin Q, Hao Y
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2309537
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2309537
Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer.
Ye LY, Li YS, Ge T, Liu LC, Si JX, Yang X, Fan WJ, Liu XZ, Zhang YN, Wang JW, Wang SB, Zou H, Zheng YL, Jin KT, Mao ZW, Cai Y, Mou XZ
Advanced healthcare materials 2024 Jul;13(17):e2304136
Advanced healthcare materials 2024 Jul;13(17):e2304136
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Wang R, Feng W, Wang Y, Jiang Y, Lin Y, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death.
Hu Q, Wang S, Cheng R, Liu Y, Chang Z, Huang Y, Chen Y, Luo X, Zhou L, Wang B, Gao Y, Chen H, Liu R, Zhang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155219
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155219
IFITM3 overexpression reverses insufficient healing benefits of small extracellular vesicles from high-fat-diet BMSCs in sepsis via the HMGB1 pathway.
Cui J, Chen C, Zhou X, Shan W, Jian Y, Feng L, Li P, Sun Y, Yi W
International immunopharmacology 2024 Jan 5;126:111250
International immunopharmacology 2024 Jan 5;126:111250
Tumorous IRE1α facilitates CD8(+)T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma.
Yang Y, Wang S, Wang XX, Guo S, Wang H, Shi Q, Tian Y, Wang H, Zhao T, Zhang H, Zhang B, Gao T, Li C, Yi X, Guo W
Cell communication and signaling : CCS 2024 Jan 30;22(1):83
Cell communication and signaling : CCS 2024 Jan 30;22(1):83
Self-heating mitochondrion-induced free radical blast for immunogenic cell death stimulation and HCC immunotherapy.
Peng M, Dong H, Shao M, Zhang X, Sun J, Ding C, Han X, Yang Q, Sang X, Cao G
Journal of controlled release : official journal of the Controlled Release Society 2024 Feb;366:694-711
Journal of controlled release : official journal of the Controlled Release Society 2024 Feb;366:694-711
Copper-coordinated nanoassemblies based on photosensitizer-chemo prodrugs and checkpoint inhibitors for enhanced apoptosis-cuproptosis and immunotherapy.
Liang W, Han C, Zhang D, Liu C, Zhu M, Xu F, Fang C, Zhang S, Liu C, Li Y
Acta biomaterialia 2024 Feb;175:341-352
Acta biomaterialia 2024 Feb;175:341-352
Cathepsin B-Responsive Programmed Brain Targeted Delivery System for Chemo-Immunotherapy Combination Therapy of Glioblastoma.
Jiang S, Li W, Yang J, Zhang T, Zhang Y, Xu L, Hu B, Li Z, Gao H, Huang Y, Ruan S
ACS nano 2024 Feb 27;18(8):6445-6462
ACS nano 2024 Feb 27;18(8):6445-6462
Proton-Gradient-Driven Porphyrin-Based Liposome Remote-Loaded with Imiquimod as In Situ Nanoadjuvants for Synergistically Augmented Tumor Photoimmunotherapy.
Liu D, Fu L, Gong L, Li S, Li K, Liu K, Yang D
ACS applied materials & interfaces 2024 Feb 21;16(7):8403-8416
ACS applied materials & interfaces 2024 Feb 21;16(7):8403-8416
Design, synthesis, and antitumor mechanism investigation of iridium(III) complexes conjugated with ibuprofen.
Chen SQ, Lu XY, Zhu LY, Zhu H, Li RT, Ye RR
Journal of inorganic biochemistry 2024 Aug;257:112596
Journal of inorganic biochemistry 2024 Aug;257:112596
Exosomes derived from bone marrow mesenchymal stem cells alleviate biliary ischemia reperfusion injury in fatty liver transplantation by inhibiting ferroptosis.
Tian X, Wu L, Li X, Zheng W, Zuo H, Song H
Molecular and cellular biochemistry 2024 Apr;479(4):881-894
Molecular and cellular biochemistry 2024 Apr;479(4):881-894
SYVN1 modulates papillary thyroid carcinoma progression by destabilizing HMGB1.
Duan F, Kong F, Jiang T, Liu H
Cell division 2024 Apr 28;19(1):15
Cell division 2024 Apr 28;19(1):15
Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis.
Zhang D, Li Z, Gao Y, Sun H
Aging 2024 Apr 19;16(8):7277-7292
Aging 2024 Apr 19;16(8):7277-7292
Identification of a novel FOXO3 agonist that protects against alcohol induced liver injury.
Peng J, Liang G, Li Y, Mao S, Zhang C, Wang Y, Li Z
Biochemical and biophysical research communications 2024 Apr 16;704:149690
Biochemical and biophysical research communications 2024 Apr 16;704:149690
Increased serum levels of high-mobility group box 1 protein and the location characteristics in the patients of intracranial aneurysms.
Lyu Y, Tu H, Luo J, Wang C, Li A, Zhou Y, Zhao J, Wang H, Hu J
Brain research 2024 Apr 1;1828:148759
Brain research 2024 Apr 1;1828:148759
MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway.
Hu Y, Hu C, Yin J, Zhong J, Deng Y, Yang G
Anais da Academia Brasileira de Ciencias 2023;95(suppl 1):e20220750
Anais da Academia Brasileira de Ciencias 2023;95(suppl 1):e20220750
ESE-1 mediates lipopolysaccharide-induced BV2 cell inflammation via upregulation of HMGB1 expression.
Lu Y, Ding J, Huang J, Zhao Y
Journal of biosciences 2023;48
Journal of biosciences 2023;48
Radioimmunotherapy Targeting B7-H3 in situ glioma models enhanced antitumor efficacy by Reconstructing the tumor microenvironment.
Zheng M, Wang Y, Fu F, Zhang K, Wang Y, Zhao S, Liu Q, Mu H, Zhang X, Miao L
International journal of biological sciences 2023;19(13):4278-4290
International journal of biological sciences 2023;19(13):4278-4290
Multifunctional Nanoplatform-Mediated Chemo-Photothermal Therapy Combines Immunogenic Cell Death with Checkpoint Blockade to Combat Triple-Negative Breast Cancer and Distant Metastasis.
Zhu H, Yang K, Yao H, Chen X, Yan S, He Y, Cao Y, Luo J, Wang D
International journal of nanomedicine 2023;18:3109-3124
International journal of nanomedicine 2023;18:3109-3124
A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.
Yao Q, Tang Y, Dai S, Huang L, Jiang Z, Zheng S, Sun M, Xu Y, Lu R, Sun T, Huang H, Jiang X, Yao X, Lin G, Kou L, Chen R
Advanced healthcare materials 2023 Sep;12(24):e2300571
Advanced healthcare materials 2023 Sep;12(24):e2300571
San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2 signalling pathway.
Zhang Z, Zheng Y, Chen N, Xu C, Deng J, Feng X, Liu W, Ma C, Chen J, Cai T, Xu Y, Wang S, Cao Y, Ge G, Jia C, Cao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154931
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154931
MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling.
Cao H, Yang P, Liu J, Shao Y, Li H, Lai P, Wang H, Liu A, Guo B, Tang Y, Bai X, Li K
Nature communications 2023 Oct 4;14(1):6190
Nature communications 2023 Oct 4;14(1):6190
Autophagy-amplifying nanoparticles evoke immunogenic cell death combined with anti-PD-1/PD-L1 for residual tumors immunotherapy after RFA.
Zhang S, Huang Y, Pi S, Chen H, Ye F, Wu C, Li L, Ye Q, Lin Y, Su Z
Journal of nanobiotechnology 2023 Oct 3;21(1):360
Journal of nanobiotechnology 2023 Oct 3;21(1):360
Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma.
Wang S, Guo Q, Xu R, Lin P, Deng G, Xia X
Journal of nanobiotechnology 2023 Oct 19;21(1):383
Journal of nanobiotechnology 2023 Oct 19;21(1):383
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.
Qu L, Wang F, Ma X
Heliyon 2023 Nov;9(11):e21955
Heliyon 2023 Nov;9(11):e21955
Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated metastasis and cisplatin resistance in cervical cancer.
Ma T, Guo J, Han J, Li L, Ren Y, Huang J, Diao G, Zheng X, Zheng Y
Molecular carcinogenesis 2023 Nov;62(11):1645-1658
Molecular carcinogenesis 2023 Nov;62(11):1645-1658
Activation of autophagy by in situ Zn(2+) chelation reaction for enhanced tumor chemoimmunotherapy.
Yang Y, Zhu Y, Wang K, Miao Y, Zhang Y, Gao J, Qin H, Zhang Y
Bioactive materials 2023 Nov;29:116-131
Bioactive materials 2023 Nov;29:116-131
Keratinocyte derived HMGB1 aggravates psoriasis dermatitis via facilitating inflammatory polarization of macrophages and hyperproliferation of keratinocyte.
Chen J, Fu Y, Xiong S
Molecular immunology 2023 Nov;163:1-12
Molecular immunology 2023 Nov;163:1-12
Analysis of CRSsNP Proteome Using a Highly Multiplexed Approach in Nasal Mucus.
Pesold VV, Wendler O, Morgenthaler L, Gröhn F, Mueller SK
American journal of rhinology & allergy 2023 May;37(3):348-359
American journal of rhinology & allergy 2023 May;37(3):348-359
Chemical characterization of the polyphenolic rich fraction of Thunbergia erecta and its therapeutic potential against doxorubicin and cyclophosphamide-induced cognitive impairment in rats.
El-Din MIG, George MY, Youssef FS
Journal of ethnopharmacology 2023 May 10;307:116213
Journal of ethnopharmacology 2023 May 10;307:116213
Neutrophil extracellular traps contribute to coagulopathy after traumatic brain injury.
Jin J, Wang F, Tian J, Zhao X, Dong J, Wang N, Liu Z, Zhao H, Li W, Mang G, Hu S
JCI insight 2023 Mar 22;8(6)
JCI insight 2023 Mar 22;8(6)
Dapagliflozin ameliorates diabetic renal injury through suppressing the self-perpetuating cycle of inflammation mediated by HMGB1 feedback signaling in the kidney.
Yuan Y, Sun M, Jin Z, Zheng C, Ye H, Weng H
European journal of pharmacology 2023 Mar 15;943:175560
European journal of pharmacology 2023 Mar 15;943:175560
HMGB1 coordinates with Brahma-related gene 1 to promote epithelial-mesenchymal transition via the PI3K/Akt/mTOR pathway in BEAS-2B cells.
Deng X, Niu Z, Hao C, Lin J, Yao W
Experimental cell research 2023 Mar 15;424(2):113522
Experimental cell research 2023 Mar 15;424(2):113522
Atrazine induces phagocytotic dysfunction of microglia depends on nucleocytoplasmic translocation of acetylated HMGB1.
Shi G, Zhang C, Li G, Wang K, Cai Q, Huang M
Ecotoxicology and environmental safety 2023 Mar 1;252:114583
Ecotoxicology and environmental safety 2023 Mar 1;252:114583
Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway.
Teng S, Zhu Z, Wu C, He Y, Zhou S
International immunopharmacology 2023 Jun;119:110198
International immunopharmacology 2023 Jun;119:110198
NSAID-Au(I) Complexes Induce ROS-Driven DAMPs and Interpose Inflammation to Stimulate the Immune Response against Ovarian Cancer.
Xu Z, Lu Q, Shan M, Jiang G, Liu Y, Yang Z, Lu Y, Liu W
Journal of medicinal chemistry 2023 Jun 22;66(12):7813-7833
Journal of medicinal chemistry 2023 Jun 22;66(12):7813-7833
ROS-responsive self-activatable photosensitizing agent for photodynamic-immunotherapy of cancer.
Wang N, Zhao Z, Xiao X, Mo L, Yao W, Yang H, Wang J, Wei X, Yuan Y, Yang R, Jiang X
Acta biomaterialia 2023 Jul 1;164:511-521
Acta biomaterialia 2023 Jul 1;164:511-521
Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway.
Ma T, Zhang H, Li T, Bai J, Wu Z, Cai T, Chen Y, Xia X, Du Y, Fu W
Phytotherapy research : PTR 2023 Jan;37(1):181-194
Phytotherapy research : PTR 2023 Jan;37(1):181-194
Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1.
Li T, Ren X, Li T, Yu L, Teng M, Zheng Y, Lei A
International journal of molecular sciences 2023 Jan 30;24(3)
International journal of molecular sciences 2023 Jan 30;24(3)
Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus.
Luo Z, Xu M, Zhang L, Zhang H, Xu Z, Xu Z
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1/TLR4/NF-κB pathway.
Wu J, Hao Z, Wang Y, Yan D, Meng J, Ma H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Feb;172:113561
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Feb;172:113561
Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.
Zhang L, Xu L, Wang Y, Zhang X, Xue T, Sun Q, Tang H, Li M, Cao X, Shi F, Zhang G, Zhang S, Hu Z
Cellular signalling 2023 Feb;102:110554
Cellular signalling 2023 Feb;102:110554
Acupuncture exerts preventive effects in rats of chronic unpredictable mild stress: The involvement of inflammation in amygdala and brain-spleen axis.
Chen W, Chen Y, Cheng W, Li P, Shen J, Tong T, Lai L, Yan S, Huang Z, Li J, Huang S, Meng X
Biochemical and biophysical research communications 2023 Feb 26;646:86-95
Biochemical and biophysical research communications 2023 Feb 26;646:86-95
Biomimetic Prussian blue nanocomplexes for chemo-photothermal treatment of triple-negative breast cancer by enhancing ICD.
Long Y, Fan J, Zhou N, Liang J, Xiao C, Tong C, Wang W, Liu B
Biomaterials 2023 Dec;303:122369
Biomaterials 2023 Dec;303:122369
Prolonged Antibiotic Use in a Preclinical Model of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-like Pathology via Increased micro-RNA 21-Induced PTEN Inhibition That Is Correlated with Low Host Lachnospiraceae Abundance.
Trivedi A, Bose D, Saha P, Roy S, More M, Skupsky J, Klimas NG, Chatterjee S
Cells 2023 Dec 27;13(1)
Cells 2023 Dec 27;13(1)
Nanointegrative In Situ Reprogramming of Tumor-Intrinsic Lipid Droplet Biogenesis for Low-Dose Radiation-Activated Ferroptosis Immunotherapy.
Zhang Q, Wang X, Zhao Y, Cheng Z, Fang D, Liu Y, Tian G, Li M, Luo Z
ACS nano 2023 Dec 26;17(24):25419-25438
ACS nano 2023 Dec 26;17(24):25419-25438
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes.
Kato R, Yamada T, Noda T, Tanaka S, Kohda Y, Ijiri Y
Toxicology in vitro : an international journal published in association with BIBRA 2023 Aug;90:105606
Toxicology in vitro : an international journal published in association with BIBRA 2023 Aug;90:105606
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation.
Mo J, Lu Z, Peng J, Li XP, Lan L, Wang H, Peng Y
Journal of psychiatric research 2023 Aug;164:150-161
Journal of psychiatric research 2023 Aug;164:150-161
Hypermethylation of RNF125 promotes autophagy-induced oxidative stress in asthma by increasing HMGB1 stability.
Hu J, Ding R, Liu S, Wang J, Li J, Shang Y
iScience 2023 Aug 18;26(8):107503
iScience 2023 Aug 18;26(8):107503
An artificial intelligence network-guided signature for predicting outcome and immunotherapy response in lung adenocarcinoma patients based on 26 machine learning algorithms.
Zhang N, Zhang H, Liu Z, Dai Z, Wu W, Zhou R, Li S, Wang Z, Liang X, Wen J, Zhang X, Zhang B, Ouyang S, Zhang J, Luo P, Li X, Cheng Q
Cell proliferation 2023 Apr;56(4):e13409
Cell proliferation 2023 Apr;56(4):e13409
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
An D, Qi X, Li K, Xu W, Wang Y, Chen X, Sha S, Wu C, Du Y, Chen L
Cellular and molecular neurobiology 2023 Apr;43(3):1283-1300
Cellular and molecular neurobiology 2023 Apr;43(3):1283-1300
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Zheng Z, Cao F, Ding YX, Lu JD, Fu YQ, Liu L, Guo YL, Liu S, Sun HC, Cui YQ, Li F
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
Potential influences of expression levels of MFGE8 and HMGB1 on the intestinal mucosal barrier function and inflammatory response after blunt abdominal injury in rats.
Tao L, Xu H, He Q
Acta cirurgica brasileira 2022;37(3):e370303
Acta cirurgica brasileira 2022;37(3):e370303
miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2.
Li X, Wu L, Tian X, Zheng W, Yuan M, Tian X, Zuo H, Song H, Shen Z
Oxidative medicine and cellular longevity 2022;2022:6520789
Oxidative medicine and cellular longevity 2022;2022:6520789
The lncRNA SEMA3B-AS1/HMGB1/FBXW7 Axis Mediates the Peritoneal Metastasis of Gastric Cancer by Regulating BGN Protein Ubiquitination.
Huang G, Xiang Z, Wu H, He Q, Dou R, Yang C, Song J, Huang S, Wang S, Xiong B
Oxidative medicine and cellular longevity 2022;2022:5055684
Oxidative medicine and cellular longevity 2022;2022:5055684
PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cells.
Kim JO, Baek SE, Jeon EY, Choi JM, Jang EJ, Kim CD
PloS one 2022;17(3):e0265191
PloS one 2022;17(3):e0265191
Aggravated renal fibrosis is positively associated with the activation of HMGB1-TLR2/4 signaling in STZ-induced diabetic mice.
Yuan Y, Liu Y, Sun M, Ye H, Feng Y, Liu Z, Pan L, Weng H
Open life sciences 2022;17(1):1451-1461
Open life sciences 2022;17(1):1451-1461
HMGB1 overexpression promotes a malignant phenotype and radioresistance in ESCC.
Dong J, Zhang X, Du X, Zou N, Shen W, Ma M, Wang Y, Zhu S
Journal of Cancer 2022;13(9):2717-2726
Journal of Cancer 2022;13(9):2717-2726
Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling.
Huang D, Wang P, Chen J, Li Y, Zhu M, Tang Y, Zhou W
Frontiers in immunology 2022;13:995791
Frontiers in immunology 2022;13:995791
Acteoside attenuates RSV-induced lung injury by suppressing necroptosis and regulating metabolism.
Ling X, Zhou J, Jin T, Xu W, Sun X, Li W, Ding Y, Liang M, Zhu C, Zhao P, Hu C, Yuan B, Xie T, Tao J
Frontiers in pharmacology 2022;13:870928
Frontiers in pharmacology 2022;13:870928
Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier-Free Nanoassembly of Fluorinated Prodrug and siRNA.
Wu P, Zhang H, Sun M, Mao S, He Q, Shi Y, Deng Y, Dong Z, Xu Q, Zhao C, Zhang W, Sun B
Advanced materials (Deerfield Beach, Fla.) 2022 Sep;34(38):e2203019
Advanced materials (Deerfield Beach, Fla.) 2022 Sep;34(38):e2203019
The HN1/HMGB1 axis promotes the proliferation and metastasis of hepatocellular carcinoma and attenuates the chemosensitivity to oxaliplatin.
Wang R, Fu Y, Yao M, Cui X, Zhao Y, Lu X, Li Y, Lin Y, He S
The FEBS journal 2022 Oct;289(20):6400-6419
The FEBS journal 2022 Oct;289(20):6400-6419
One night of sleep deprivation induces release of small extracellular vesicles into circulation and promotes platelet activation by small EVs.
Wang C, Li L, Yang C, Zhang Z, Li X, Wang Y, Lv X, Qi X, Song G
Journal of cellular and molecular medicine 2022 Oct;26(19):5033-5043
Journal of cellular and molecular medicine 2022 Oct;26(19):5033-5043
Highly effective identification of drug targets at the proteome level by pH-dependent protein precipitation.
Zhang X, Wang K, Wu S, Ruan C, Li K, Wang Y, Zhu H, Liu X, Liu Z, Li G, Hu L, Ye M
Chemical science 2022 Nov 2;13(42):12403-12418
Chemical science 2022 Nov 2;13(42):12403-12418
Enhanced Immunotherapy Based on Combining the Pro-phagocytosis and Anti-phagocytosis Checkpoint Blockade for Tumor Eradication.
Song W, Yang F, Yang H, Xu Y, Song SJ, Meng Y, Wei ST, Wan T, Zhou Y, Zhou B, Kuang J, Yu T, Qiu WX
Journal of medicinal chemistry 2022 Nov 10;65(21):14832-14842
Journal of medicinal chemistry 2022 Nov 10;65(21):14832-14842
ENSMUST00000147869 regulates proliferation and fibrosis of mesangial cells in diabetic nephropathy by interacting with Hspa9.
Wang M, Chen X, Zhang H, Li L, Xu Y, Lu W, Lu Y
IUBMB life 2022 May;74(5):419-432
IUBMB life 2022 May;74(5):419-432
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Zhao R, Wang L, Wang T, Xian P, Wang H, Long Q
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation.
Duan X, Wen J, Zhang M, Wang C, Xiang Y, Wang L, Yu C, Deng G, Yan M, Zhang B, Fang P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 May;149:112884
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 May;149:112884
Low-Dose Propranolol Prevents Functional Decline in Catecholamine-Induced Acute Heart Failure in Rats.
Tsai CK, Chen BH, Chen HH, Hsieh RJ, Lee JC, Chu YT, Lu WH
Toxics 2022 May 7;10(5)
Toxics 2022 May 7;10(5)
Contribution of Necroptosis to Myofiber Death in Idiopathic Inflammatory Myopathies.
Peng QL, Zhang YM, Liu YC, Liang L, Li WL, Tian XL, Zhang L, Yang HX, Lu X, Wang GC
Arthritis & rheumatology (Hoboken, N.J.) 2022 Jun;74(6):1048-1058
Arthritis & rheumatology (Hoboken, N.J.) 2022 Jun;74(6):1048-1058
Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy.
Jin J, Yuan P, Yu W, Lin J, Xu A, Xu X, Lou J, Yu T, Qian C, Liu B, Song J, Li L, Piao Y, Xie T, Shen Y, Tao H, Tang J
ACS nano 2022 Jul 26;16(7):10327-10340
ACS nano 2022 Jul 26;16(7):10327-10340
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Niu Z, Lin J, Hao C, Xu X, Wang C, Dai K, Deng X, Deng M, Guo Y, Yao W
International journal of environmental research and public health 2022 Jul 18;19(14)
International journal of environmental research and public health 2022 Jul 18;19(14)
Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor.
Chen B, Qin G, Xiao J, Deng X, Lin A, Liu H
Journal of neuroinflammation 2022 Jul 13;19(1):181
Journal of neuroinflammation 2022 Jul 13;19(1):181
Corilagin induces apoptosis and inhibits autophagy of HL‑60 cells by regulating miR‑451/HMGB1 axis.
Jia S, He D, Liang X, Cheng P, Liu J, Chen M, Wang C, Zhang H, Meng C
Molecular medicine reports 2022 Jan;25(1)
Molecular medicine reports 2022 Jan;25(1)
MFGE8 decreased neuronal apoptosis and neuroinflammation to ameliorate early brain injury induced by subarachnoid hemorrhage through the inhibition of HMGB1.
Qiu J, Li W, Mu R, Wang L, Guo L, Ma L
Human & experimental toxicology 2022 Jan-Dec;41:9603271221093635
Human & experimental toxicology 2022 Jan-Dec;41:9603271221093635
Epithelial microRNA-30a-3p targets RUNX2/HMGB1 axis to suppress airway eosinophilic inflammation in asthma.
Wu W, Gao J, Chen D, Chen G, Feng Y, Chang C, Chen S, Yi L, Zhen G
Respiratory research 2022 Jan 29;23(1):17
Respiratory research 2022 Jan 29;23(1):17
Protective Effect of MFG-E8 on Necroptosis-Induced Intestinal Inflammation and Enteroendocrine Cell Function in Diabetes.
Hua X, Li B, Yu F, Zhao W, Tan Y, Li X, Fu C, Yu X, Gao H, Cheng M
Nutrients 2022 Jan 29;14(3)
Nutrients 2022 Jan 29;14(3)
Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy.
Wang K, Jiang M, Zhou J, Liu Y, Zong Q, Yuan Y
ACS nano 2022 Jan 25;16(1):721-735
ACS nano 2022 Jan 25;16(1):721-735
Anlotinib combined with temozolomide suppresses glioblastoma growth via mediation of JAK2/STAT3 signaling pathway.
Xu P, Wang H, Pan H, Chen J, Deng C
Cancer chemotherapy and pharmacology 2022 Feb;89(2):183-196
Cancer chemotherapy and pharmacology 2022 Feb;89(2):183-196
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Chen Y, Qu L, Li Y, Chen C, He W, Shen L, Zhang R
Inflammation 2022 Feb;45(1):253-266
Inflammation 2022 Feb;45(1):253-266
HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway.
Feng L, Liang L, Zhang S, Yang J, Yue Y, Zhang X
Autophagy 2022 Feb;18(2):320-339
Autophagy 2022 Feb;18(2):320-339
Metformin attenuated sepsis-associated liver injury and inflammatory response in aged mice.
Song H, Zhang X, Zhai R, Liang H, Song G, Yuan Y, Xu Y, Yan Y, Qiu L, Sun T
Bioengineered 2022 Feb;13(2):4598-4609
Bioengineered 2022 Feb;13(2):4598-4609
Regorafenib and reactive metabolite of sunitinib activate inflammasomes: Implications for multi tyrosine kinase inhibitor-Iiduced immune related adverse events.
Kato R, Ijiri Y
Die Pharmazie 2022 Feb 1;77(2):54-58
Die Pharmazie 2022 Feb 1;77(2):54-58
Acteoside alleviates dextran sulphate sodium‑induced ulcerative colitis via regulation of the HO‑1/HMGB1 signaling pathway.
Guo W, Wang X, Liu F, Chen S, Wang S, Zhang Q, Yuan L, Du S
Molecular medicine reports 2022 Dec;26(6)
Molecular medicine reports 2022 Dec;26(6)
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism.
Li T, Zhou L, Fan M, Chen Z, Yan L, Lu H, Jia M, Wu H, Shan L
Stem cell reviews and reports 2022 Aug;18(6):2088-2103
Stem cell reviews and reports 2022 Aug;18(6):2088-2103
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease.
Dong Y, Yu H, Li X, Bian K, Zheng Y, Dai M, Feng X, Sun Y, He Y, Yu B, Zhang H, Wu J, Yu X, Wu H, Kong W
Journal of neuroinflammation 2022 Aug 15;19(1):205
Journal of neuroinflammation 2022 Aug 15;19(1):205
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation.
Chen Y, Hao C, Chen W, Cheng W, Li P, Shen J, Tong T, Yan S, Huang S, He T, Huang Z, Meng X
Neuroscience letters 2022 Aug 10;785:136787
Neuroscience letters 2022 Aug 10;785:136787
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.
Yu C, Lei Z, Li X, Huang LH, Li ZQ, Zhu HW, Han D, Huang H, Yu X
Biochemical genetics 2022 Apr;60(2):598-610
Biochemical genetics 2022 Apr;60(2):598-610
Inhibition of Neutrophil Extracellular Traps Formation by Cl-Amidine Alleviates Lipopolysaccharide-Induced Endometritis and Uterine Tissue Damage.
Shen W, Oladejo AO, Ma X, Jiang W, Zheng J, Imam BH, Wang S, Wu X, Ding X, Ma B, Yan Z
Animals : an open access journal from MDPI 2022 Apr 29;12(9)
Animals : an open access journal from MDPI 2022 Apr 29;12(9)
Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs.
Wu Z, Zhou G, Wang H, Yao P
International journal of molecular sciences 2022 Apr 18;23(8)
International journal of molecular sciences 2022 Apr 18;23(8)
TRAIL-modified, doxorubicin-embedded periodic mesoporous organosilica nanoparticles for targeted drug delivery and efficient antitumor immunotherapy.
Feng X, Li F, Zhang L, Liu W, Wang X, Zhu R, Qiao ZA, Yu B, Yu X
Acta biomaterialia 2022 Apr 15;143:392-405
Acta biomaterialia 2022 Apr 15;143:392-405
Fe(III)-Chelated Polydopamine Nanoparticles for Synergistic Tumor Therapies of Enhanced Photothermal Ablation and Antitumor Immune Activation.
Xu N, Hu A, Pu X, Li J, Wang X, Wang J, Huang Z, Liao X, Yin G
ACS applied materials & interfaces 2022 Apr 13;14(14):15894-15910
ACS applied materials & interfaces 2022 Apr 13;14(14):15894-15910
Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury.
Noda T, Kato R, Hattori T, Furukawa Y, Ijiri Y, Tanaka K
Life sciences 2022 Apr 1;294:120351
Life sciences 2022 Apr 1;294:120351
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
Macrophage contributes to radiation-induced anti-tumor abscopal effect on transplanted breast cancer by HMGB1/TNF-α signaling factors.
Zhu L, Hu S, Chen Q, Zhang H, Fu J, Zhou Y, Bai Y, Pan Y, Shao C
International journal of biological sciences 2021;17(4):926-941
International journal of biological sciences 2021;17(4):926-941
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood-brain barrier during kainic acid-induced brain damage.
Yu H, He B, Han X, Yan T
Open life sciences 2021;16(1):845-855
Open life sciences 2021;16(1):845-855
Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling.
Guo Q, Qu H, Zhang H, Zhong X
Drug design, development and therapy 2021;15:4559-4574
Drug design, development and therapy 2021;15:4559-4574
Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.
Huang Y, Zhang G, Zhu Q, Wu X, Wu L
Cancer management and research 2021;13:7399-7409
Cancer management and research 2021;13:7399-7409
HMGB1 Mediated Inflammation and Autophagy Contribute to Endometriosis.
Huang J, Chen X, Lv Y
Frontiers in endocrinology 2021;12:616696
Frontiers in endocrinology 2021;12:616696
Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem.
Ren J, Zhou J, Liu H, Jiao X, Cao Y, Xu Z, Kang Y, Xue P
Theranostics 2021;11(19):9470-9491
Theranostics 2021;11(19):9470-9491
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Methionine enkephalin (MENK) suppresses lung cancer by regulating the Bcl-2/Bax/caspase-3 signaling pathway and enhancing natural killer cell-driven tumor immunity.
Zhang S, Liu N, Ma M, Huang H, Handley M, Bai X, Shan F
International immunopharmacology 2021 Sep;98:107837
International immunopharmacology 2021 Sep;98:107837
Aiduqing formula suppresses breast cancer metastasis via inhibiting CXCL1-mediated autophagy.
Yang B, Peng F, Zhang Y, Wang X, Wang S, Zheng Y, Zhang J, Zeng Y, Wang N, Peng C, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153628
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153628
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent.
Mondal A, Saha P, Bose D, Chatterjee S, Seth RK, Xiao S, Porter DE, Brooks BW, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S
Toxicology 2021 Sep;461:152901
Toxicology 2021 Sep;461:152901
An NIR-Fluorophore-Based Theranostic for Selective Initiation of Tumor Pyroptosis-Induced Immunotherapy.
Wang K, Xiao X, Jiang M, Li J, Zhou J, Yuan Y
Small (Weinheim an der Bergstrasse, Germany) 2021 Sep;17(36):e2102610
Small (Weinheim an der Bergstrasse, Germany) 2021 Sep;17(36):e2102610
Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy.
Luo L, Qin B, Jiang M, Xie L, Luo Z, Guo X, Zhang J, Li X, Zhu C, Du Y, Peng L, You J
Journal of nanobiotechnology 2021 Sep 30;19(1):297
Journal of nanobiotechnology 2021 Sep 30;19(1):297
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
Chen A, Yang F, Kuang J, Xiong Y, Mi BB, Zhou Y, Hu JJ, Song SJ, Wan T, Wan ZZ, Huang HY, Li XR, Song W, Qiu WX
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer.
Jin F, Qi J, Liu D, You Y, Shu G, Du Y, Wang J, Xu X, Ying X, Ji J, Du Y
Journal of controlled release : official journal of the Controlled Release Society 2021 Sep 10;337:90-104
Journal of controlled release : official journal of the Controlled Release Society 2021 Sep 10;337:90-104
Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation.
Qiu C, Wang M, Yu W, Rong Z, Zheng HS, Sun T, Liu SB, Zhao MG, Wu YM
Molecular neurobiology 2021 Oct;58(10):5272-5288
Molecular neurobiology 2021 Oct;58(10):5272-5288
Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation.
Zhu CJ, Yang WG, Li DJ, Song YD, Chen SY, Wang QF, Liu YN, Zhang Y, Cheng B, Wu ZW, Cui ZC
World journal of gastroenterology 2021 Nov 28;27(44):7669-7686
World journal of gastroenterology 2021 Nov 28;27(44):7669-7686
Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats.
Kong L, Ma Y, Wang Z, Liu N, Ma G, Liu C, Shi R, Du G
International immunopharmacology 2021 May;94:107507
International immunopharmacology 2021 May;94:107507
Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis.
Zhang K, Liu D, Zhao J, Shi S, He X, Da P, You Y, You B
Cell death & disease 2021 May 28;12(6):554
Cell death & disease 2021 May 28;12(6):554
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Kishi S, Nishiguchi Y, Honoki K, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Kawahara I, Goto K, Nakashima C, Kido A, Tanaka Y, Luo Y, Kuniyasu H
International journal of molecular sciences 2021 May 13;22(10)
International journal of molecular sciences 2021 May 13;22(10)
Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events.
Imano H, Kato R, Ijiri Y, Hayashi T
Toxicology in vitro : an international journal published in association with BIBRA 2021 Mar;71:105063
Toxicology in vitro : an international journal published in association with BIBRA 2021 Mar;71:105063
miR-548b Suppresses Melanoma Cell Growth, Migration, and Invasion by Negatively Regulating Its Target Gene HMGB1.
Feng XE
Cancer biotherapy & radiopharmaceuticals 2021 Mar;36(2):189-201
Cancer biotherapy & radiopharmaceuticals 2021 Mar;36(2):189-201
Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.
Liu N, Liu C, Yang Y, Ma G, Wei G, Liu S, Kong L, Du G
Pharmacological research 2021 Jul;169:105650
Pharmacological research 2021 Jul;169:105650
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Pei L, Le Y, Chen H, Feng J, Liu Z, Zhu J, Wang C, Chen L, Dou X, Lu D
Fitoterapia 2021 Jul;152:104922
Fitoterapia 2021 Jul;152:104922
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
Huang Y, Guan Z, Dai X, Shen Y, Wei Q, Ren L, Jiang J, Xiao Z, Jiang Y, Liu D, Huang Z, Xu X, Luo Y, Zhao C
Nature communications 2021 Jul 14;12(1):4310
Nature communications 2021 Jul 14;12(1):4310
HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target.
Liu L, Zhang J, Zhang X, Cheng P, Liu L, Huang Q, Liu H, Ren S, Wei P, Wang C, Dou C, Chen L, Liu X, Zhang H, Chen M
Journal of molecular medicine (Berlin, Germany) 2021 Jan;99(1):107-118
Journal of molecular medicine (Berlin, Germany) 2021 Jan;99(1):107-118
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Wang R, Wu G, Dai T, Lang Y, Chi Z, Yang S, Dong D
Experimental and therapeutic medicine 2021 Jan;21(1):66
Experimental and therapeutic medicine 2021 Jan;21(1):66
Organic Near-Infrared-II Nanophotosensitizer for Safe Cancer Phototheranostics and Improving Immune Microenvironment against Metastatic Tumor.
Song C, Ran J, Wei Z, Wang Y, Chen S, Lin L, Zhang G, Cai Y, Han W
ACS applied materials & interfaces 2021 Jan 27;13(3):3547-3558
ACS applied materials & interfaces 2021 Jan 27;13(3):3547-3558
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway.
Qiu C, Yang LD, Yu W, Tian DD, Gao MR, Wang WJ, Li XB, Wu YM, Wang M
Metabolic brain disease 2021 Feb;36(2):273-283
Metabolic brain disease 2021 Feb;36(2):273-283
Neonatal Streptococcus Pneumoniae pneumonia induces airway SMMHC expression through HMGB1/TLR4/ERK.
Li Y, Guo Z, Zhang G, Tian X, Li Q, Luo Z
Immunology letters 2021 Dec;240:149-158
Immunology letters 2021 Dec;240:149-158
miR-142-3p and HMGB1 Are Negatively Regulated in Proliferation, Apoptosis, Migration, and Autophagy of Cartilage Endplate Cells.
Wang B, Ji D, Xing W, Li F, Huang Z, Zheng W, Xue J, Zhu Y, Yang X
Cartilage 2021 Dec;13(2_suppl):592S-603S
Cartilage 2021 Dec;13(2_suppl):592S-603S
CCN2 Aggravates the Immediate Oxidative Stress-DNA Damage Response following Renal Ischemia-Reperfusion Injury.
Valentijn FA, Knoppert SN, Pissas G, Rodrigues-Diez RR, Marquez-Exposito L, Broekhuizen R, Mokry M, Kester LA, Falke LL, Goldschmeding R, Ruiz-Ortega M, Eleftheriadis T, Nguyen TQ
Antioxidants (Basel, Switzerland) 2021 Dec 20;10(12)
Antioxidants (Basel, Switzerland) 2021 Dec 20;10(12)
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Kato R, Ijiri Y, Hayashi T
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal.
Wang Z, Chen L, Ma Y, Li X, Hu A, Wang H, Wang W, Li X, Tian B, Dong J
Journal of nanobiotechnology 2021 Aug 12;19(1):243
Journal of nanobiotechnology 2021 Aug 12;19(1):243
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Song Z, Wu T, Sun J, Wang H, Hua F, Nicolas YSM, Kc R, Chen K, Jin Z, Liu J, Zhang M
Journal of cellular and molecular medicine 2021 Apr;25(7):3272-3283
Journal of cellular and molecular medicine 2021 Apr;25(7):3272-3283
Rosmarinic acid alleviates di-2-ethylhexyl phthalate (DEHP) -induced thyroid dysfunction via multiple inflammasomes activation.
Wu H, Ma K, Na X
The Journal of toxicological sciences 2020;45(7):373-390
The Journal of toxicological sciences 2020;45(7):373-390
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
The Journal of toxicological sciences 2020;45(11):673-680
The Journal of toxicological sciences 2020;45(11):673-680
Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury.
Wang S, Sun Y, Bai Y, Zhou N, Chen N, Miller EJ, Zhang Y, Li W
Mediators of inflammation 2020;2020:8094347
Mediators of inflammation 2020;2020:8094347
VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice.
Sun Z, Nyanzu M, Yang S, Zhu X, Wang K, Ru J, Yu E, Zhang H, Wang Z, Shen J, Zhuge Q, Huang L
Oxidative medicine and cellular longevity 2020;2020:7879629
Oxidative medicine and cellular longevity 2020;2020:7879629
Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement.
Fan QL, Wang JW, Zhang SL, Liu T, Zhao J, You SP
Evidence-based complementary and alternative medicine : eCAM 2020;2020:2957094
Evidence-based complementary and alternative medicine : eCAM 2020;2020:2957094
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Gao W, Feng Z, Zhang S, Wu B, Geng X, Fan G, Duan Y, Li K, Liu K, Peng C
BioMed research international 2020;2020:1860637
BioMed research international 2020;2020:1860637
Self-enforcing HMGB1/NF-κB/HIF-1α Feedback Loop Promotes Cisplatin Resistance in Hepatocellular Carcinoma Cells.
Song Y, Zou X, Zhang D, Liu S, Duan Z, Liu L
Journal of Cancer 2020;11(13):3893-3902
Journal of Cancer 2020;11(13):3893-3902
Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease.
Gan P, Ding L, Hang G, Xia Q, Huang Z, Ye X, Qian X
Frontiers in pharmacology 2020;11:776
Frontiers in pharmacology 2020;11:776
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124
Frontiers in pharmacology 2020;11:544124
A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury.
Bachmann M, Lamprecht L, Gonther S, Pfeilschifter J, Mühl H
Journal of cellular and molecular medicine 2020 Sep;24(18):10356-10366
Journal of cellular and molecular medicine 2020 Sep;24(18):10356-10366
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385
Molecular medicine reports 2020 Sep;22(3):2373-2385
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury.
Fan H, Tang HB, Chen Z, Wang HQ, Zhang L, Jiang Y, Li T, Yang CF, Wang XY, Li X, Wu SX, Zhang GL
Journal of neuroinflammation 2020 Oct 9;17(1):295
Journal of neuroinflammation 2020 Oct 9;17(1):295
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis.
Jin Z, Sun J, Song Z, Chen K, Nicolas YSM, Kc R, Ma Q, Liu J, Zhang M
NPJ Regenerative medicine 2020 Oct 30;5(1):19
NPJ Regenerative medicine 2020 Oct 30;5(1):19
Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury.
Wilkinson ML, Abramova E, Guo C, Gow JG, Murray A, Koudelka A, Cechova V, Freeman BA, Gow AJ
Toxicology and applied pharmacology 2020 Nov 15;407:115236
Toxicology and applied pharmacology 2020 Nov 15;407:115236
Impact of perioperative high mobility group box chromosomal protein 1 expression on long-term outcomes in patients with esophageal squamous cell carcinoma.
Tsujimoto H, Horiguchi H, Takahata R, Ono S, Yaguchi Y, Nomura S, Ito N, Harada M, Nagata H, Ishibashi Y, Kouzu K, Tsuchiya S, Itazaki Y, Fujishima S, Kishi Y, Ueno H
Journal of gastroenterology and hepatology 2020 May;35(5):788-794
Journal of gastroenterology and hepatology 2020 May;35(5):788-794
Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.
Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541
Upregulation of microRNA-204 improves insulin resistance of polycystic ovarian syndrome via inhibition of HMGB1 and the inactivation of the TLR4/NF-κB pathway.
Jiang B, Xue M, Xu D, Song Y, Zhu S
Cell cycle (Georgetown, Tex.) 2020 Mar;19(6):697-710
Cell cycle (Georgetown, Tex.) 2020 Mar;19(6):697-710
Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model.
Wang D, Zhou M, Wang Y, Sun S
Canadian journal of physiology and pharmacology 2020 Jun;98(6):351-356
Canadian journal of physiology and pharmacology 2020 Jun;98(6):351-356
Pannexin1 Channel Inhibitor ((10)panx) Protects Against Transient Focal Cerebral Ischemic Injury by Inhibiting RIP3 Expression and Inflammatory Response in Rats.
Wei R, Bao W, He F, Meng F, Liang H, Luo B
Neuroscience 2020 Jun 15;437:23-33
Neuroscience 2020 Jun 15;437:23-33
NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity.
Jin F, Qi J, Zhu M, Liu D, You Y, Shu G, Du Y, Wang J, Yu H, Sun M, Xu X, Shen Q, Ying X, Ji J, Du Y
ACS applied materials & interfaces 2020 Jul 22;12(29):32372-32387
ACS applied materials & interfaces 2020 Jul 22;12(29):32372-32387
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Liu J, Yang HM, Li SZ
Brain research 2020 Jan 1;1726:146495
Brain research 2020 Jan 1;1726:146495
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
Ying C, Ying L, Yanxia L, Le W, Lili C
Acta histochemica 2020 Feb;122(2):151485
Acta histochemica 2020 Feb;122(2):151485
Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages.
Luo XQ, Duan JX, Yang HH, Zhang CY, Sun CC, Guan XX, Xiong JB, Zu C, Tao JH, Zhou Y, Guan CX
Journal of cellular physiology 2020 Dec;235(12):9910-9921
Journal of cellular physiology 2020 Dec;235(12):9910-9921
Role of HMGB1/TLR4 Axis in Ischemia/Reperfusion-Impaired Extracellular Glutamate Clearance in Primary Astrocytes.
Lin CH, Chen HY, Wei KC
Cells 2020 Dec 3;9(12)
Cells 2020 Dec 3;9(12)
Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons.
Wang B, Huang X, Pan X, Zhang T, Hou C, Su WJ, Liu LL, Li JM, Wang YX
Brain, behavior, and immunity 2020 Aug;88:132-143
Brain, behavior, and immunity 2020 Aug;88:132-143
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
Lan Y, Yan R, Shan W, Chu J, Sun R, Wang R, Zhao Y, Wang Z, Zhang N, Yao J
Journal of cellular and molecular medicine 2020 Aug;24(15):8518-8531
Journal of cellular and molecular medicine 2020 Aug;24(15):8518-8531
circ_0007385 served as competing endogenous RNA for miR-519d-3p to suppress malignant behaviors and cisplatin resistance of non-small cell lung cancer cells.
Ye Y, Zhao L, Li Q, Xi C, Li Y, Li Z
Thoracic cancer 2020 Aug;11(8):2196-2208
Thoracic cancer 2020 Aug;11(8):2196-2208
Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway.
Ge X, Meng X, Fei D, Kang K, Wang Q, Zhao M
3 Biotech 2020 Aug;10(8):369
3 Biotech 2020 Aug;10(8):369
Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes.
Zhang Y, Cai W, Han G, Zhou S, Li J, Chen M, Li H
International journal of molecular medicine 2020 Apr;45(4):1225-1236
International journal of molecular medicine 2020 Apr;45(4):1225-1236
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Qu L, Chen C, He W, Chen Y, Li Y, Wen Y, Zhou S, Jiang Y, Yang X, Zhang R, Shen L
American journal of translational research 2019;11(4):2042-2055
American journal of translational research 2019;11(4):2042-2055
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats.
Zhong X, Xiao Q, Liu Z, Wang W, Lai CH, Yang W, Yue P, Ye Q, Xiao J
Molecular medicine reports 2019 Sep;20(3):2101-2110
Molecular medicine reports 2019 Sep;20(3):2101-2110
Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling.
Liu ZZ, Weng HB, Zhang LJ, Pan LY, Sun W, Chen HX, Chen MY, Zeng T, Zhang YY, Chen DF, Li H
Chinese journal of natural medicines 2019 Sep;17(9):641-649
Chinese journal of natural medicines 2019 Sep;17(9):641-649
Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways.
Huang X, Xi Y, Mao Z, Chu X, Zhang R, Ma X, Ni B, Cheng H, You H
European journal of pharmacology 2019 Sep 15;859:172481
European journal of pharmacology 2019 Sep 15;859:172481
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Dioscin attenuates Bleomycin-Induced acute lung injury via inhibiting the inflammatory response in mice.
Wu ZL, Wang J
Experimental lung research 2019 Oct;45(8):236-244
Experimental lung research 2019 Oct;45(8):236-244
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, Ma X, You H
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
Journal of cellular and molecular medicine 2019 Nov;23(11):7525-7534
NRP1 regulates HMGB1 in vascular endothelial cells under high homocysteine condition.
Ma Y, Zhang Z, Chen R, Shi R, Zeng P, Chen R, Leng Y, Chen AF
American journal of physiology. Heart and circulatory physiology 2019 May 1;316(5):H1039-H1046
American journal of physiology. Heart and circulatory physiology 2019 May 1;316(5):H1039-H1046
Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis.
Hua S, Ma M, Fei X, Zhang Y, Gong F, Fang M
International immunopharmacology 2019 Mar;68:145-155
International immunopharmacology 2019 Mar;68:145-155
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis.
Cao Y, Liu X, Guo SW
Scientific reports 2019 Jun 25;9(1):9272
Scientific reports 2019 Jun 25;9(1):9272
Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps.
Zhou J, Yang Y, Gan T, Li Y, Hu F, Hao N, Yuan B, Chen Y, Zhang M
Oncology letters 2019 Jul;18(1):181-188
Oncology letters 2019 Jul;18(1):181-188
Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice.
Feng Y, Weng H, Ling L, Zeng T, Zhang Y, Chen D, Li H
International journal of biological macromolecules 2019 Jul 1;132:1001-1011
International journal of biological macromolecules 2019 Jul 1;132:1001-1011
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.
Chen J, Jiang Z, Zhou X, Sun X, Cao J, Liu Y, Wang X
Cardiovascular drugs and therapy 2019 Feb;33(1):45-54
Cardiovascular drugs and therapy 2019 Feb;33(1):45-54
Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain.
Balan I, Beattie MC, O'Buckley TK, Aurelian L, Morrow AL
Scientific reports 2019 Feb 4;9(1):1220
Scientific reports 2019 Feb 4;9(1):1220
HMGB1 is mechanistically essential in the development of experimental pulmonary hypertension.
Dai M, Xiao R, Cai L, Ge T, Zhu L, Hu Q
American journal of physiology. Cell physiology 2019 Feb 1;316(2):C175-C185
American journal of physiology. Cell physiology 2019 Feb 1;316(2):C175-C185
XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy.
Wang N, Yang B, Muhetaer G, Wang S, Zheng Y, Lu J, Li M, Zhang F, Situ H, Lin Y, Wang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109519
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109519
Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer.
Nishiguchi Y, Oue N, Fujiwara-Tani R, Sasaki T, Ohmori H, Kishi S, Mori S, Mori T, Ikeda N, Matsumoto S, Wakatsuki K, Luo Y, Yasui W, Sho M, Kuniyasu H
International journal of molecular sciences 2019 Dec 30;21(1)
International journal of molecular sciences 2019 Dec 30;21(1)
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway.
Yu Y, Yang Y, Yang M, Wang C, Xie K, Yu Y
International immunopharmacology 2019 Apr;69:11-18
International immunopharmacology 2019 Apr;69:11-18
Platelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability.
Romaldini A, Ulivi V, Nardini M, Mastrogiacomo M, Cancedda R, Descalzi F
Cells 2019 Apr 9;8(4)
Cells 2019 Apr 9;8(4)
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L
Life sciences 2019 Apr 15;223:158-165
Life sciences 2019 Apr 15;223:158-165
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378
Frontiers in pharmacology 2018;9:1378
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent.
Alsousi AA, Igwe OJ
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3847-3858
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3847-3858
The multidisciplinary support in preventing alcohol relapse after liver transplantation: A single-center experience.
Attilia ML, Lattanzi B, Ledda R, Galli AM, Farcomeni A, Rotondo C, Di Gregorio V, Mennini G, Poli E, Attilia F, Ginanni Corradini S, Rossi M, Merli M
Clinical transplantation 2018 May;32(5):e13243
Clinical transplantation 2018 May;32(5):e13243
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Wang H, Chen Y, Guo J, Shan T, Deng K, Chen J, Cai L, Zhou H, Zhao Q, Jin S, Xia J
Scientific reports 2018 May 4;8(1):7080
Scientific reports 2018 May 4;8(1):7080
Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation.
Wang Z, Han Q, Guo YL, Liu XH, Qiu T
Acta cirurgica brasileira 2018 Mar;33(3):238-249
Acta cirurgica brasileira 2018 Mar;33(3):238-249
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Association of HMGB1, BRCA1 and P62 expression in ovarian cancer and chemotherapy sensitivity.
Li S, Wei Y
Oncology letters 2018 Jun;15(6):9572-9576
Oncology letters 2018 Jun;15(6):9572-9576
Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer.
Weng L, Guo L, Vachani A, Mesaros C, Blair IA
Analytical chemistry 2018 Jun 19;90(12):7552-7560
Analytical chemistry 2018 Jun 19;90(12):7552-7560
Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing high mobility group box 1 and inflammatory cytokines.
Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Kuwabara S
Clinical and experimental immunology 2018 Jul;193(1):47-54
Clinical and experimental immunology 2018 Jul;193(1):47-54
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization.
Gao T, Chen Z, Chen H, Yuan H, Wang Y, Peng X, Wei C, Yang J, Xu C
Biochemical and biophysical research communications 2018 Feb 26;497(1):430-436
Biochemical and biophysical research communications 2018 Feb 26;497(1):430-436
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
Zhao X, Yin L, Fang L, Xu L, Sun P, Xu M, Liu K, Peng J
International immunopharmacology 2018 Dec;65:458-469
International immunopharmacology 2018 Dec;65:458-469
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.
Xu Z, Duan F, Lu H, Abdulkadhim Dragh M, Xia Y, Liang H, Hong L
Cell death & disease 2018 Dec 5;9(12):1170
Cell death & disease 2018 Dec 5;9(12):1170
Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke.
Li M, Chen S, Shi X, Lyu C, Zhang Y, Tan M, Wang C, Zang N, Liu X, Hu Y, Shen J, Zhou L, Gu Y
Journal of neuroinflammation 2018 Aug 23;15(1):237
Journal of neuroinflammation 2018 Aug 23;15(1):237
Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.
Yang M, Lv Y, Tian X, Lou J, An R, Zhang Q, Li M, Xu L, Dong Z
Frontiers in neuroscience 2017;11:583
Frontiers in neuroscience 2017;11:583
Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes.
Lv ZH, Phuong TA, Jin SJ, Li XX, Xu M
Oncotarget 2017 Oct 31;8(53):91291-91305
Oncotarget 2017 Oct 31;8(53):91291-91305
Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.
Luo F, Herrup K, Qi X, Yang Y
Experimental neurology 2017 Jun;292:21-34
Experimental neurology 2017 Jun;292:21-34
The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.
Khan MR, Xiang S, Song Z, Wu M
The EMBO journal 2017 Dec 1;36(23):3483-3500
The EMBO journal 2017 Dec 1;36(23):3483-3500
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Pathophysiology of Endometriosis: Role of High Mobility Group Box-1 and Toll-Like Receptor 4 Developing Inflammation in Endometrium.
Yun BH, Chon SJ, Choi YS, Cho S, Lee BS, Seo SK
PloS one 2016;11(2):e0148165
PloS one 2016;11(2):e0148165
Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae.
Chen Q, Yin YX, Wei J, Tong M, Shen F, Zhao M, Chamley L
Cytokine 2016 Sep;85:30-6
Cytokine 2016 Sep;85:30-6
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C, Wang Q, Tang TS
PLoS biology 2016 Nov;14(11):e2000733
PLoS biology 2016 Nov;14(11):e2000733
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Yao H, Hu C, Yin L, Tao X, Xu L, Qi Y, Han X, Xu Y, Zhao Y, Wang C, Peng J
International immunopharmacology 2016 Jul;36:132-141
International immunopharmacology 2016 Jul;36:132-141
Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury.
Fan H, Zhang K, Shan L, Kuang F, Chen K, Zhu K, Ma H, Ju G, Wang YZ
Molecular neurodegeneration 2016 Feb 3;11:14
Molecular neurodegeneration 2016 Feb 3;11:14
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X
Nature communications 2016 Aug 26;7:12646
Nature communications 2016 Aug 26;7:12646
The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.
Owusu L, Wang B, Du Y, Li W, Xin Y
Journal of Cancer 2015;6(2):128-38
Journal of Cancer 2015;6(2):128-38
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury.
Fan H, Tang HB, Kang J, Shan L, Song H, Zhu K, Wang J, Ju G, Wang YZ
Neuroscience 2015 Dec 17;311:362-73
Neuroscience 2015 Dec 17;311:362-73
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tao X, Wan X, Xu Y, Xu L, Qi Y, Yin L, Han X, Lin Y, Peng J
Transplantation 2014 Sep 27;98(6):604-11
Transplantation 2014 Sep 27;98(6):604-11
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong D, Xu L, Han X, Qi Y, Xu Y, Yin L, Liu K, Peng J
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo.
Guo X, Sesaki H, Qi X
The Biochemical journal 2014 Jul 1;461(1):137-46
The Biochemical journal 2014 Jul 1;461(1):137-46
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
miR-200c inhibits metastasis of breast cancer cells by targeting HMGB1.
Chang BP, Wang DS, Xing JW, Yang SH, Chu Q, Yu SY
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Apr;34(2):201-206
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Apr;34(2):201-206
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation.
Yu H, Zheng L, Yin L, Xu L, Qi Y, Han X, Xu Y, Liu K, Peng J
International immunopharmacology 2014 Apr;19(2):233-44
International immunopharmacology 2014 Apr;19(2):233-44
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.
Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J
The Journal of cell biology 2013 May 13;201(4):613-29
The Journal of cell biology 2013 May 13;201(4):613-29
Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells.
Rosu-Myles M, She YM, Fair J, Muradia G, Mehic J, Menendez P, Prasad SS, Cyr TD
PloS one 2012;7(6):e38954
PloS one 2012;7(6):e38954
RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer.
DiNorcia J, Lee MK, Moroziewicz DN, Winner M, Suman P, Bao F, Remotti HE, Zou YS, Yan SF, Qiu W, Su GH, Schmidt AM, Allendorf JD
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2012 Jan;16(1):104-12; discussion 112
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2012 Jan;16(1):104-12; discussion 112
RAGE signaling significantly impacts tumorigenesis and hepatic tumor growth in murine models of colorectal carcinoma.
DiNorcia J, Moroziewicz DN, Ippagunta N, Lee MK, Foster M, Rotterdam HZ, Bao F, Zhou YS, Yan SF, Emond J, Schmidt AM, Allendorf JD
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2010 Nov;14(11):1680-90
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2010 Nov;14(11):1680-90
The C/EBPbeta isoform, liver-inhibitory protein (LIP), induces autophagy in breast cancer cell lines.
Abreu MM, Sealy L
Experimental cell research 2010 Nov 15;316(19):3227-38
Experimental cell research 2010 Nov 15;316(19):3227-38
HMGB1 activates nuclear factor-κB signaling by RAGE and increases the production of TNF-α in human umbilical vein endothelial cells.
Luan ZG, Zhang H, Yang PT, Ma XC, Zhang C, Guo RX
Immunobiology 2010 Dec;215(12):956-62
Immunobiology 2010 Dec;215(12):956-62
Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma.
Yu HT, Yu M, Li CY, Zhan YQ, Xu WX, Li YH, Li W, Wang ZD, Ge CH, Yang XM
The Journal of biological chemistry 2009 May 15;284(20):13335-13347
The Journal of biological chemistry 2009 May 15;284(20):13335-13347
Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.
Yu M, Wang J, Li W, Yuan YZ, Li CY, Qian XH, Xu WX, Zhan YQ, Yang XM
Nucleic acids research 2008 Mar;36(4):1209-19
Nucleic acids research 2008 Mar;36(4):1209-19
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 10829-1-AP(HMGB1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HMGB1 (IP:10829-1-AP, 3ug; Detection:10829-1-AP 1:500) with HepG2 cells lysate 2900ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HMGB1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HMGB1. This antibody recognizes human,mouse,rat antigen. The HMGB1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
