10-4024

antibody from ABEOMICS Inc.
Targeting: HMGB1 DKFZp686A04236, HMG1, HMG3, SBP-1
Provider product page for 10-4024

Antibody data

Product number
10-4024 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-HMGB1 Antibody
Antibody type
Monoclonal
Description
HMGB1 (High-mobility group protein B1) is a 25 kDa non-histone chromatin protein, secreted by immune cells through leaderless secretory pathway. HMGB1 supports transcription and also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol. HMGB1 has the ability to bend DNA in order to facilitate binding of other proteins to the DNA. HMGB1 has one important role in V(D)J recombination where act as a cofactor of the RAG complex. HMGB1 stimulates a plethora of cellular responses like inflammation, attracting inflammatory cells, recruiting stem cells and promoting their proliferation. HMGB1 is highly expressed in human kidney, tonsils, adipose tissue, adrenal cortex and amniotic fluid.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant HMGB1
protein (amino acids 1- 200) was us
ed as the immunogen for this antibo
dy.
Isotype
IgG
Antibody clone number
ABM24D3
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
HMGB1 protein structure - 10-4024 shown in red.