66525-1-Ig

antibody from Proteintech Group

Targeting: HMGB1 DKFZp686A04236, HMG1, HMG3, SBP-1

Provider product page for 66525-1-Ig

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Antibody data

Antibody Data
Antigen structure
References [35]
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Product number: 66525-1-Ig - Provider product page
Provider: Proteintech Group
Product name: HMGB1 antibody
Antibody type: Monoclonal
Description: HMGB1 antibody (Cat. #66525-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse and has been validated for the following applications: WB, ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1D12A6
Vial size: 20ul, 150ul

HMGB1 protein structure - 66525-1-Ig shown in red.

Submitted references Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD.

Yang L, Niu K, Wang J, Shen W, Jiang R, Liu L, Song W, Wang X, Zhang X, Zhang R, Wei D, Fan M, Jia L, Tao K
Journal of hepatology 2024 Oct;81(4):651-666

Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy.

Sun S, He Y, Xu J, Leng S, Liu Y, Wan H, Yan L, Xu Y
Journal of controlled release : official journal of the Controlled Release Society 2024 Mar;367:470-485

Alpha-Emitter Radium-223 Induces STING-Dependent Pyroptosis to Trigger Robust Antitumor Immunity.

Yang M, Liu H, Lou J, Zhang J, Zuo C, Zhu M, Zhang X, Yin Y, Zhang Y, Qin S, Zhang H, Fan X, Dang Y, Cheng C, Cheng Z, Yu F
Small (Weinheim an der Bergstrasse, Germany) 2024 Mar;20(9):e2307448

Glioma-targeted oxaliplatin/ferritin clathrate reversing the immunosuppressive microenvironment through hijacking Fe(2+) and boosting Fenton reaction.

Li X, Cheng Y, Yang Z, Ji Q, Huan M, Ye W, Liu M, Zhang B, Liu D, Zhou S
Journal of nanobiotechnology 2024 Mar 5;22(1):93

Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.

Liang W, Wei R, Zhu X, Li J, Lin A, Chen J, Wu W, Jie Q
Molecular medicine (Cambridge, Mass.) 2024 Mar 16;30(1):38

METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.

Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573

Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.

Xiang Q, Qu L, Lei H, Duan Z, Zhu C, Yuwen W, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278

Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination.

Kumar G, Fang S, Golosova D, Lu KT, Brozoski DT, Vazirabad I, Sigmund CD
Function (Oxford, England) 2023;4(5):zqad034

Gankyrin-mediated interaction between cancer cells and tumor-associated macrophages facilitates prostate cancer progression and androgen deprivation therapy resistance.

Peng G, Wang C, Wang H, Qu M, Dong K, Yu Y, Jiang Y, Gan S, Gao X
Oncoimmunology 2023;12(1):2173422

PTMA binds to HMGB1 to regulate mitochondrial oxidative phosphorylation and thus affect the malignant progression of esophageal squamous cell carcinoma.

Chen S, He R, Lin X, Zhang W, Chen H, Xu R, Kang M
Journal of thoracic disease 2023 Mar 31;15(3):1302-1318

Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.

Li K, Feng Z, Wang L, Ma X, Wang L, Liu K, Geng X, Peng C
Inflammation 2023 Jun;46(3):1061-1076

Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus.

Luo Z, Xu M, Zhang L, Zhang H, Xu Z, Xu Z
Molecular medicine reports 2023 Feb;27(2)

MIR-107/HMGB1/FGF-2 axis responds to excessive mechanical stretch to promote rapid repair of vascular endothelial cells.

Ma H, Wang L, Sun H, Yu Q, Yang T, Wang Y, Niu B, Jia Y, Liu Y, Liang Z, An M, Guo J
Archives of biochemistry and biophysics 2023 Aug;744:109686

A marine-derived small molecule induces immunogenic cell death against triple-negative breast cancer through ER stress-CHOP pathway.

Wen H, Zhong Y, Yin Y, Qin K, Yang L, Li D, Yu W, Yang C, Deng Z, Hong K
International journal of biological sciences 2022;18(7):2898-2913

ORFV infection enhances CXCL16 secretion and causes oncolysis of lung cancer cells through immunogenic apoptosis.

Wang R, Mo J, Luo X, Zhang G, Liu F, Luo S
Frontiers in cellular and infection microbiology 2022;12:910466

A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses.

Wang X, Liu Y, Xue C, Hu Y, Zhao Y, Cai K, Li M, Luo Z
Nature communications 2022 Sep 28;13(1):5685

Laminar shear stress inhibits inflammation by activating autophagy in human aortic endothelial cells through HMGB1 nuclear translocation.

Meng Q, Pu L, Qi M, Li S, Sun B, Wang Y, Liu B, Li F
Communications biology 2022 May 6;5(1):425

Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating.

Yan B, Liu C, Wang S, Li H, Jiao J, Lee WSV, Zhang S, Hou Y, Hou Y, Ma X, Fan H, Lv Y, Liu X
Journal of materials chemistry. B 2022 Jul 20;10(28):5364-5374

NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.

Feng Z, Qin Y, Huo F, Jian Z, Li X, Geng J, Li Y, Wu J
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166287

Preventive effect of sanguinarine on intestinal injury in mice exposed to whole abdominal irradiation.

Gu J, Zhao L, Chen YZ, Guo YX, Sun Y, Guo Q, Duan GX, Li C, Tang ZB, Zhang ZX, Qin LQ, Xu JY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112496

Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.

Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351

Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.

Wang K, Zhang B, Zhang B, Wu K, Tian T, Yan W, Huang M
Neurotoxicity research 2022 Apr;40(2):520-529

Anti-PD-L1 DNAzyme Loaded Photothermal Mn(2+) /Fe(3+) Hybrid Metal-Phenolic Networks for Cyclically Amplified Tumor Ferroptosis-Immunotherapy.

Liu P, Shi X, Peng Y, Hu J, Ding J, Zhou W
Advanced healthcare materials 2022 Apr;11(8):e2102315

The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.

Du Y, Zhong F, Cheng H, Li T, Chen Y, Tan P, Huang M, Liang T, Liu Y, Xia X, Fu W
Oxidative medicine and cellular longevity 2021;2021:4628050

High Mobility Group Box 1 Promotes Lung Cancer Cell Migration and Motility via Regulation of Dynamin-Related Protein 1.

Liu WL, Li CY, Cheng WC, Chang CY, Chen YH, Lu CY, Wang SC, Liu YR, Cheng MH, Chong IW, Liu PL
International journal of molecular sciences 2021 Mar 31;22(7)

Anti-Oxidative and Immuno-Protective Effect of Camel Milk on Radiation-Induced Intestinal Injury in C57BL/6 J Mice.

Chen YZ, Li C, Gu J, Lv SC, Song JY, Tang ZB, Duan GX, Qin LQ, Zhao L, Xu JY
Dose-response : a publication of International Hormesis Society 2021 Jan-Mar;19(1):15593258211003798

Cascade-Responsive Hierarchical Nanosystems for Multisite Specific Drug Exposure and Boosted Chemoimmunotherapy.

Zhang J, Zhang Y, Zhao B, Lv M, Chen E, Zhao C, Jiang L, Qian H, Huang D, Zhong Y, Chen W
ACS applied materials & interfaces 2021 Dec 15;13(49):58319-58328

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6-HMGB1 deacetylation.

Wei W, Guo X, Gu L, Jia J, Yang M, Yuan W, Rong S
Stem cell research & therapy 2021 Apr 13;12(1):235

The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.

Cui H, Cheng Y, He Y, Cheng W, Zhao W, Zhao H, Zhou FH, Wang L, Dong J, Cai S
Molecular medicine reports 2020 Nov;22(5):3723-3734

Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation.

Su J, Pan YW, Wang SQ, Li XZ, Huang F, Ma SP
International immunopharmacology 2020 Mar;80:106181

HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway.

Huang M, Guo M, Wang K, Wu K, Li Y, Tian T, Wang Y, Yan W, Zhou Z, Yang H
Neurotoxicity research 2020 Apr;37(4):913-925

Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells.

Corrêa R, Silva LFF, Ribeiro DJS, Almeida RDN, Santos IO, Corrêa LH, de Sant'Ana LP, Assunção LS, Bozza PT, Magalhães KG
Frontiers in immunology 2019;10:2927

SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.

Le K, Chibaatar Daliv E, Wu S, Qian F, Ali AI, Yu D, Guo Y
International immunopharmacology 2019 Oct;75:105779

Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.

Dai C, Xiao X, Li D, Tun S, Wang Y, Velkov T, Tang S
Cell death & disease 2018 Nov 26;9(12):1164

Treatment of colon cancer with liver X receptor agonists induces immunogenic cell death.

Wang Q, Ren M, Feng F, Chen K, Ju X
Molecular carcinogenesis 2018 Jul;57(7):903-910

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