HPA031700

antibody from Atlas Antibodies

Targeting: CGAS C6orf150, MB21D1

Western blot (Data presented on provider website)

Antibody Data

Product number

HPA031700

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA031700, RRID:AB_10601693

Product name

Anti-MB21D1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human MB21D1, Gene description: Mab-21 domain containing 1, Alternative Gene Names: C6orf150, Validated applications: WB, Uniprot ID: Q8N884, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS

Moody C, Gusho E, Laimins L
PLOS Pathogens 2022;18(7):e1010725

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OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity

Xie W, Tian S, Yang J, Cai S, Jin S, Zhou T, Wu Y, Chen Z, Ji Y, Cui J
Autophagy 2022;18(10):2288-2302

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cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity

Liu X, Li L, Gao F, Jiang Y, Yuan W, Li G, Yu L, Zhou Y, Tong G, Zhao K
Frontiers in Immunology 2022;13

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The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25’s RNA Binding Ability

Chiang C, Dvorkin S, Chiang J, Potter R, Gack M, Horner S
mBio 2021;12(2)

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Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

Bakhoum M, Francis J, Agustinus A, Earlie E, Di Bona M, Abramson D, Duran M, Masilionis I, Molina E, Shoushtari A, Goldbaum M, Mischel P, Bakhoum S, Laughney A
Nature Communications 2021;12(1)

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STING nuclear partners contribute to innate immune signaling responses.

Dixon CR, Malik P, de Las Heras JI, Saiz-Ros N, de Lima Alves F, Tingey M, Gaunt E, Richardson AC, Kelly DA, Goldberg MW, Towers GJ, Yang W, Rappsilber J, Digard P, Schirmer EC
iScience 2021 Sep 24;24(9):103055

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Human Papillomavirus E7 Oncoprotein Subverts Host Innate Immunity via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes

Lo Cigno I, Calati F, Borgogna C, Zevini A, Albertini S, Martuscelli L, De Andrea M, Hiscott J, Landolfo S, Gariglio M, Banks L
Journal of Virology 2020;94(4)

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Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer

Vasudevan A, Baruah P, Smith J, Wang Z, Sayles N, Andrews P, Kendall J, Leu J, Chunduri N, Levy D, Wigler M, Storchová Z, Sheltzer J
Developmental Cell 2020;52(4):413-428.e6

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Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Lv M, Chen M, Zhang R, Zhang W, Wang C, Zhang Y, Wei X, Guan Y, Liu J, Feng K, Jing M, Wang X, Liu Y, Mei Q, Han W, Jiang Z
Cell Research 2020;30(11):966-979

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The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling

Song B, Greco T, Lum K, Taber C, Cristea I
Molecular & Cellular Proteomics 2020;19(7):1193-1208

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Tight nuclear tethering of cGAS is essential for preventing autoreactivity

Volkman H, Cambier S, Gray E, Stetson D
eLife 2019;8

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Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity

Riedl W, Acharya D, Lee J, Liu G, Serman T, Chiang C, Chan Y, Diamond M, Gack M
Cell Host & Microbe 2019;26(4):493-503.e6

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

Dunphy G, Flannery S, Almine J, Connolly D, Paulus C, Jønsson K, Jakobsen M, Nevels M, Bowie A, Unterholzner L
Molecular Cell 2018;71(5):745-760.e5

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Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS

Lum K, Song B, Federspiel J, Diner B, Howard T, Cristea I
Cell Systems 2018;7(6):627-642.e6

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Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Verrier E, Yim S, Heydmann L, El Saghire H, Bach C, Turon‐Lagot V, Mailly L, Durand S, Lucifora J, Durantel D, Pessaux P, Manel N, Hirsch I, Zeisel M, Pochet N, Schuster C, Baumert T
Hepatology 2018;68(5):1695-1709

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Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition

Fenerty K, Padget M, Wolfson B, Gameiro S, Su Z, Lee J, Rabizadeh S, Soon-Shiong P, Hodge J
Journal for ImmunoTherapy of Cancer 2018;6(1)

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IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Almine J, O’Hare C, Dunphy G, Haga I, Naik R, Atrih A, Connolly D, Taylor J, Kelsall I, Bowie A, Beard P, Unterholzner L
Nature Communications 2017;8(1)

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IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

Jønsson K, Laustsen A, Krapp C, Skipper K, Thavachelvam K, Hotter D, Egedal J, Kjolby M, Mohammadi P, Prabakaran T, Sørensen L, Sun C, Jensen S, Holm C, Lebbink R, Johannsen M, Nyegaard M, Mikkelsen J, Kirchhoff F, Paludan S, Jakobsen M
Nature Communications 2017;8(1)

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Dengue virus activates cGAS through the release of mitochondrial DNA

Sun B, Sundström K, Chew J, Bist P, Gan E, Tan H, Goh K, Chawla T, Tang C, Ooi E
Scientific Reports 2017;7(1)

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cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler B, Baghdasaryan E, Marion K, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati V, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim K, Hinton D, Leitinger N, Cambier J, Buxbaum J, Kenney M, Jazwinski S, Nagai H, Hara I, West A, Fitzgerald K, Sadda S, Gelfand B, Ambati J
Nature Medicine 2017;24(1):50-61

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Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

Cerboni S, Jeremiah N, Gentili M, Gehrmann U, Conrad C, Stolzenberg M, Picard C, Neven B, Fischer A, Amigorena S, Rieux-Laucat F, Manel N
Journal of Experimental Medicine 2017;214(6):1769-1785

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Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann M, Schulz T
Proceedings of the National Academy of Sciences 2016;113(8)

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Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

Hasan M, Fermaintt C, Gao N, Sakai T, Miyazaki T, Jiang S, Li Q, Atkinson J, Morse H, Lehrman M, Yan N
Immunity 2015;43(3):463-474

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T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication

Wu Y, Berg R, Rahbek S, Kofod-Olsen E, Holm C, Melchjorsen J, Jensen D, Hansen A, Jørgensen L, Ostergaard L, Tolstrup M, Larsen C, Paludan S, Jakobsen M, Mogensen T
PLoS ONE 2014;9(1):e84513

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Listeria monocytogenes induces IFNβ expression through an IFI16‐, cGAS‐ and STING‐dependent pathway

Hansen K, Prabakaran T, Laustsen A, Jørgensen S, Rahbæk S, Jensen S, Nielsen R, Leber J, Decker T, Horan K, Jakobsen M, Paludan S
The EMBO Journal 2014;33(15):1654-1666

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

Schoggins J, MacDuff D, Imanaka N, Gainey M, Shrestha B, Eitson J, Mar K, Richardson R, Ratushny A, Litvak V, Dabelic R, Manicassamy B, Aitchison J, Aderem A, Elliott R, García-Sastre A, Racaniello V, Snijder E, Yokoyama W, Diamond M, Virgin H, Rice C
Nature 2013;505(7485):691-695