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- Antibody Data
- Antigen structure
- References [164]
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- Product number
- 26416-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- cGAS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated cGAS antibody (Cat. #26416-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Prognostic value of cGAS-STING-IRF3 signaling in cholangiocarcinoma patients.
Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.
Promotion of hepatocellular carcinoma by small nuclear ribonucleoprotein polypeptide F through upregulation of transmembrane P24 trafficking protein 2 and triggering of the cGAS-STING pathway.
SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways.
TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses.
SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING.
Anti-Inflammatory Effects of Curcumin via the Nrf2-cGAS-STING-NF-κB Pathway in MH7A Rheumatoid Arthritis Fibroblast-like Synoviocytes.
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Silica-induced telomere dysfunction promotes pulmonary fibrosis through the activation of the cGAS-STING pathway.
ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging.
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Cytosolic Immunostimulatory DNA Ligands and DNA Damage Activate the Integrated Stress Response, Stress Granule Formation, and Cytokine Production.
Maidong Dishao Decoction can inhibit the activation of the cGAS-STING signaling pathway of Sjögren's syndrome by reducing oxidative stress in salivary gland epithelial cells.
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway.
DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation.
Electroacupuncture Attenuates Neuroinflammation and Postoperative Cognitive Dysfunction in Aged Rats by Suppressing the cGAS-STING Pathway.
Fumarate loss destabilizes mitochondria and activates cGAS-STING in OLP.
EMCV Non-Structural Protein 2C Antagonizes cGAS-STING-Mediated Type I Interferon Signaling via Promoting K48-Linked Polyubiquitination and Degradation of STING.
Fumarate Hydratase Restrains mtDNA Attenuates LPS-Induced Acute Lung Injury Through cGAS-STING Pathways.
An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells.
High cyclic GMP-AMP synthase and stimulator of interferon genes in cholangiocarcinoma suggest their potential as targets for treatment.
Rhapontigenin attenuates neurodegeneration in a parkinson's disease model by downregulating mtDNA-cGAS-STING-NF-κB-mediated neuroinflammation via PINK1/DRP1-dependent microglial mitophagy.
Mitochondrial DNA leakage and micronucleus formation activate the cGAS-STING pathway in aristolochic acid I-induced nephritis.
Screening and Validation of Negative Regulators of the Type I Interferon Pathway.
TFNAs induce autophagy via activation of the nonclassical cGAS-STING signalling pathway to attenuate acute lung injury in mice.
The DIAPH3/RPL6 axis regulates the cGAS-STING pathway in pancreatic cancer.
Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy.
Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury.
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery.
Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling.
PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion.
Astilbin Alleviates IL-17-Induced Hyperproliferation and Inflammation in HaCaT Cells via Inhibiting Ferroptosis Through the cGAS-STING Pathway.
Pectin/caffeic acid nanoparticles in a poloxamer thermosensitive gel for the treatment of ulcerative colitis by inhibiting cGAS-STING pathway.
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy.
Dual-modality immune nano-activator harnessing Mn(2)⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy.
The activation of cGAS-STING pathway promotes the epithelial-mesenchymal transition and inflammation in intrauterine adhesion.
Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis.
Endogenous nanoplatforms for tumor photoimmunotherapy: Hypoxia modulation and STING pathway activation.
CSDE1 enhances genotoxic drug resistance in cancer by modulating RPA2 through CSDE1-eIF3a regulatory complex.
Epithelial Atg5 Deficiency Intensifies Caspase-11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS-STING-NLRP3 Axis in Macrophages During Pseudomonas Infection.
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
TSPAN7 inhibits pancreatic cancer progression by suppressing DNA double-strand break repair and enhances sensitivity to immunochemotherapy.
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
XBP1 promotes endometrial fibrosis through cGAS-STING signaling pathway in intrauterine adhesion.
Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration.
Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo.
Overexpression of FBP1 enhances dendritic cell activation and maturation by inhibiting glycolysis and promoting the secretion of IL33 in lung adenocarcinoma.
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.
Hesperidin enhanced anti-breast cancer effect and alleviated cisplatin induced nephrotoxicity through silk fibroin delivery system.
Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the Ceruloplasmin/iron overload/mtDNA signaling pathway.
USP34 regulates PIN1-cGAS-STING axis-dependent ferroptosis in cervical cancer via SUMOylation.
Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling.
E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages.
Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction.
EXO/hydrogel system for sequential regulation of endogenous hyaline cartilage regeneration.
Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury.
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Paternal BDE-209 exposure disrupts spermatogenesis in mouse offspring via cGAS-STING pathway activation and mitophagy inhibition.
A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin.
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors.
Activation of the cGAS-STING pathway by clofoctol through mitochondrial damage in triple-negative breast cancer.
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.
Integrated Proteomics Reveals Spliceosome Dysregulation and Highlights DHX9 as a TGF-β Signaling-Driven Fibrosis Hub in Endometriosis.
Hydrogen sulfide improves poststroke depression-induced inflammation in microglial cells by enhancing endoplasmic reticulum autophagy and inhibiting the cGAS-STING pathway.
African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline.
SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis.
The relationship between tumor immunity and the cGAS-STING pathway in breast cancer: An immunohistochemical study.
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
Dronedarone hydrochloride (DH) induces pancreatic cancer cell death by triggering mtDNA-mediated pyroptosis.
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells.
A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice.
cGAS regulates metabolic reprogramming independently of STING pathway in colorectal cancer.
Pseudorabies virus usurps non-muscle myosin heavy chain IIA to dampen viral DNA recognition by cGAS for antagonism of host antiviral innate immunity.
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.
IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma.
Comparison of Immunotherapy versus Targeted Therapy Effectiveness in BRAF-Mutant Melanoma Patients and Use of cGAS Expression and Aneuploidy as Potential Prognostic Biomarkers.
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes.
Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling.
Enhancing myocardial infarction treatment through bionic hydrogel-mediated spatial combination therapy via mtDNA-STING crosstalk modulation.
Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA.
Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
Neutrophil extracellular traps induce barrier dysfunction in DSS-induced ulcerative colitis via the cGAS-STING pathway.
The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disorders.
Overexpression of ESYT3 improves radioimmune responses through activating cGAS-STING pathway in lung adenocarcinoma.
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.
Micronucleus is not a potent inducer of the cGAS/STING pathway.
Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS-STING signaling pathway.
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.
Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing.
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells.
Low dose PFDA induces DNA damage and DNA repair inhibition by promoting nuclear cGAS accumulation in ovarian epithelial cells.
cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control.
FEN1 inhibitor SC13 promotes CAR-T cells infiltration into solid tumours through cGAS-STING signalling pathway.
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.
A Bacterial mRNA-Lysis-Mediated Cargo Release Vaccine System for Regulated Cytosolic Surveillance and Optimized Antigen Delivery.
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.
NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.
Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer.
DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
Combination of STING agonist and CXCR3 antagonist disrupts immune tolerance to overcome anti-PD-L1 resistance in lung adenocarcinoma under oxidative stress.
Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS-STING Signaling Pathway.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Increasing expression of STING by ERα antagonizes LCN2 downregulation during chronic endometritis.
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
RNF144A promotes antiviral responses by modulating STING ubiquitination.
SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1.
Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling.
Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer.
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
Baicalein-loaded silk fibroin peptide nanofibers protect against cisplatin-induced acute kidney injury: Fabrication, characterization and mechanism.
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.
Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.
Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity.
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response.
Recruitment of DNA to tumor-derived microvesicles.
Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer.
Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.
Activation of the cGAS-STING signaling pathway in adenomyosis patients.
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.
Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation.
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection.
IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.
Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.
Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.
HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation.
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.
Artbua P, Kentachalee N, Sitthirak S, Sa-Ngiamwibool P, Wichian P, Deenonpoe R
PloS one 2026;21(2):e0342756
PloS one 2026;21(2):e0342756
Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.
Wang SS, Yuan RL, Wang WF, Peng Y, Hu KC, He WB, Zhao YX, Yan X, Zhang Z, Chu SF, Chen NH
Journal of advanced research 2026 May;83:315-332
Journal of advanced research 2026 May;83:315-332
Promotion of hepatocellular carcinoma by small nuclear ribonucleoprotein polypeptide F through upregulation of transmembrane P24 trafficking protein 2 and triggering of the cGAS-STING pathway.
Xie X, Pu L, Zeng J, Xu M, Yin X, Liu H, Yang J, Cao J, Song H
International journal of biological macromolecules 2026 Mar;352:151166
International journal of biological macromolecules 2026 Mar;352:151166
SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways.
Yang B, Zhang Y, Wang S, Wu Y, Diao Z, Zhang Q, Lu C, Shen M, Zhang X, Ma S, Yang C, Pei J, Xing H, Liang Y, Wang J
EMBO reports 2026 Mar;27(5):1228-1253
EMBO reports 2026 Mar;27(5):1228-1253
TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses.
Yang X, Zhong H, Cheng J, Jiang H, Tan J, Wang C, Song C, Cai G, Yang H, Wu Z
PLoS pathogens 2026 Mar;22(3):e1014023
PLoS pathogens 2026 Mar;22(3):e1014023
SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING.
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B
The Journal of general virology 2026 Mar;107(3)
The Journal of general virology 2026 Mar;107(3)
Anti-Inflammatory Effects of Curcumin via the Nrf2-cGAS-STING-NF-κB Pathway in MH7A Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Li L, Shen T, Li Z, Guo Q, Pang Q
Biomedicines 2026 Mar 9;14(3)
Biomedicines 2026 Mar 9;14(3)
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Zhang Y, Zhu Z, Ji P, Ming J, Zhou Y
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Yu Q, Guo K, Yang Y, Liu H, Han Y, Yu X, Wang J, Zhao Y, Su X, Zhu K, Zheng S, Wang S, Li W, Huang Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
Silica-induced telomere dysfunction promotes pulmonary fibrosis through the activation of the cGAS-STING pathway.
Qian Q, Pan S, Li X, Gong X, Jiang Z, Zhang X, Lou J, Feng L
Toxicology 2026 Jun;523:154451
Toxicology 2026 Jun;523:154451
ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Zhang Z, Gao J, Liao X, Zhang Z, Cao X, Gong Y, Chen W, Zhang L, Tsai HI, Wang D, Zhu H
Cell death and differentiation 2026 Jan;33(1):111-125
Cell death and differentiation 2026 Jan;33(1):111-125
Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging.
Yu S, Cheng Q, Yu Q, Cui Z, Chen H, Wu S, Jin Y, Wang Y, Li M, Lu Z
Aging cell 2026 Jan;25(1):e70350
Aging cell 2026 Jan;25(1):e70350
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
Huang K, Xiao JL, Tang JY, Pu HY, Li FH, Gao K, Yu X, Guo SZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.
Cui S, Luo X, Fan G, Jiang J, Wang Y, Yang E, Ma J, Zhang Z, Wang Y, Wang J, Wang D, Wang H, Cheng L, Tian J, Dong Z, Liu Y, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e09933
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e09933
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Zhang H, Chang A, Xu X, Peng H, Zhang K, Yang J, Li W, Wang X, Wang W, Yin X, Qu C, Dong X, Ni J
Current issues in molecular biology 2026 Jan 27;48(2)
Current issues in molecular biology 2026 Jan 27;48(2)
Cytosolic Immunostimulatory DNA Ligands and DNA Damage Activate the Integrated Stress Response, Stress Granule Formation, and Cytokine Production.
Devale T, Katuri L, Mishra G, Acharya A, Manivannan P, Hibbard BR, Malathi K
Cells 2026 Jan 13;15(2)
Cells 2026 Jan 13;15(2)
Maidong Dishao Decoction can inhibit the activation of the cGAS-STING signaling pathway of Sjögren's syndrome by reducing oxidative stress in salivary gland epithelial cells.
Zhu W, Chen L, Li Y, Gu R, Zhang Y, Lu Y, Wang Y
Journal of ethnopharmacology 2026 Jan 10;354:120470
Journal of ethnopharmacology 2026 Jan 10;354:120470
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway.
Wu T, Yu Q, Wang Y, Tang H, Guo W
International immunopharmacology 2026 Jan 1;168(Pt 2):115790
International immunopharmacology 2026 Jan 1;168(Pt 2):115790
DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation.
Niotis G, Arvanitaki ES, Theodorakis E, Schmalen A, Juretschke T, Argyros O, Tsolis KC, Bertsias G, Drakos E, Beli P, Garinis GA
Nature aging 2026 Feb;6(2):393-413
Nature aging 2026 Feb;6(2):393-413
Electroacupuncture Attenuates Neuroinflammation and Postoperative Cognitive Dysfunction in Aged Rats by Suppressing the cGAS-STING Pathway.
Ma B, Fan S, Deng J, Wei K, Li Y, Yin J, Xie L
Experimental neurobiology 2026 Feb 28;35(1):42-55
Experimental neurobiology 2026 Feb 28;35(1):42-55
Fumarate loss destabilizes mitochondria and activates cGAS-STING in OLP.
Hu Y, Chen H, Ding C, Zhang S, Chen Q, Sun H, Yang Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026 Apr;197:119127
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026 Apr;197:119127
EMCV Non-Structural Protein 2C Antagonizes cGAS-STING-Mediated Type I Interferon Signaling via Promoting K48-Linked Polyubiquitination and Degradation of STING.
Cheng R, Dong P, Xing W, Jin H, Ma T, Xie J, Wen Y, Su B, Li X, Feng R
Viruses 2026 Apr 5;18(4)
Viruses 2026 Apr 5;18(4)
Fumarate Hydratase Restrains mtDNA Attenuates LPS-Induced Acute Lung Injury Through cGAS-STING Pathways.
Jiang Z, He R, Zhong Y, Liu B, He Z
Journal of inflammation research 2025;18:5399-5413
Journal of inflammation research 2025;18:5399-5413
An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells.
Jayakumar P, Jiang T, Huang H, Deng M
Frontiers in pharmacology 2025;16:1576151
Frontiers in pharmacology 2025;16:1576151
High cyclic GMP-AMP synthase and stimulator of interferon genes in cholangiocarcinoma suggest their potential as targets for treatment.
Zin Myint HN, Saranaruk P, Paungpan N, Waraasawapati S, Pairojkul C, Saisomboon S, Settha N, Pattanachot J, Okada S, Seubwai W, Kitkhuandee A, Sawanyawisuth K, Vaeteewoottacharn K
PeerJ 2025;13:e19800
PeerJ 2025;13:e19800
Rhapontigenin attenuates neurodegeneration in a parkinson's disease model by downregulating mtDNA-cGAS-STING-NF-κB-mediated neuroinflammation via PINK1/DRP1-dependent microglial mitophagy.
Su Z, Shu H, Huang X, Ding L, Liang F, Xu Z, Zhu Z, Chen M, Wang X, Li G, Xia H, Cao Q, Zhang W, Xu P, Yang X
Cellular and molecular life sciences : CMLS 2025 Sep 6;82(1):337
Cellular and molecular life sciences : CMLS 2025 Sep 6;82(1):337
Mitochondrial DNA leakage and micronucleus formation activate the cGAS-STING pathway in aristolochic acid I-induced nephritis.
Lei YY, Hu YS, Cao YY, Xi J, Ma YN, Zhang XH, Gao QW, Fu JA, Zhang XY, Su L, Luan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115648
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115648
Screening and Validation of Negative Regulators of the Type I Interferon Pathway.
Pang Z, Yang H, Li B, Liu Y, Zhao Z, Zhu Z, Peng S, Mu X, Yu H
Advanced biology 2025 Nov;9(11):e00736
Advanced biology 2025 Nov;9(11):e00736
TFNAs induce autophagy via activation of the nonclassical cGAS-STING signalling pathway to attenuate acute lung injury in mice.
Wei C, Liu Y, Pan B, Zhang J, Chen J, Ling P, Xiang Y, Zhu S, Sun Y
BMC pulmonary medicine 2025 Nov 7;25(1):514
BMC pulmonary medicine 2025 Nov 7;25(1):514
The DIAPH3/RPL6 axis regulates the cGAS-STING pathway in pancreatic cancer.
Huang H, Lin C, Zhou C, Cui L, Rong Y
European journal of medical research 2025 Nov 29;31(1):9
European journal of medical research 2025 Nov 29;31(1):9
Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy.
Gao Y, He Y, Wang C, Zuo R, Tian X, Zuo D, Luo Y, Liu W, Feng Y, Ling A, Yue P, Gong W, Wang Y, Chen L, Liu Z, Chen P, Guo H
Cell reports. Medicine 2025 Nov 18;6(11):102434
Cell reports. Medicine 2025 Nov 18;6(11):102434
Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury.
Fan Z, Jia M, Zhou J, Zhu Z, Wu Y, Lin X, Qian Y, Lian J, Hua X, Dong J, Fang Z, Liu Y, Chen S, Xue X, Yue J, Zhu M, Wang Y, Huang Z, Teng H
Neural regeneration research 2025 Nov 1;20(11):3287-3301
Neural regeneration research 2025 Nov 1;20(11):3287-3301
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery.
Hu K, Ye J, Fan P, Zheng R, Wang S, Peng Y, Ruan Y, Yan X, Zhang Z, Chu S, Chen N
Bioactive materials 2025 May;47:181-197
Bioactive materials 2025 May;47:181-197
Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling.
Lang J, Bergner T, Zinngrebe J, Lepelley A, Vill K, Leiz S, Wlaschek M, Wagner M, Scharffetter-Kochanek K, Fischer-Posovszky P, Read C, Crow YJ, Hirschenberger M, Sparrer KMJ
EMBO reports 2025 May;26(9):2232-2261
EMBO reports 2025 May;26(9):2232-2261
PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion.
Qin W, Duan Y, Hu Z, Hou Y, Wen T, Ouyang Y, Wang Z, Sun X, Chen X, Wang KL, Luo S, Ji G, Shen Y, Dong B, Lin Y, Tian Q, Guo Z, Wu S, Xiao L, Li M, Xiao L, Wu Q, Meng Y, Liu G, Zhang W, Duan S, Bai X, Liu T, He J, Lu Z, Xu D
The Journal of experimental medicine 2025 May 5;222(5)
The Journal of experimental medicine 2025 May 5;222(5)
Astilbin Alleviates IL-17-Induced Hyperproliferation and Inflammation in HaCaT Cells via Inhibiting Ferroptosis Through the cGAS-STING Pathway.
Xu X, Zhang H, Chang A, Peng H, Li S, Zhang K, Wang W, Yin X, Qu C, Dong X, Ni J
International journal of molecular sciences 2025 May 24;26(11)
International journal of molecular sciences 2025 May 24;26(11)
Pectin/caffeic acid nanoparticles in a poloxamer thermosensitive gel for the treatment of ulcerative colitis by inhibiting cGAS-STING pathway.
Zhou S, Yu Z, Yao W, Wang M, Yang Y, Qin J, Wu X, Guo C
Colloids and surfaces. B, Biointerfaces 2025 Mar;247:114419
Colloids and surfaces. B, Biointerfaces 2025 Mar;247:114419
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy.
Li H, Wang X, Luo X, Shi H, Li J
Frontiers in bioscience (Landmark edition) 2025 Mar 5;30(3):26084
Frontiers in bioscience (Landmark edition) 2025 Mar 5;30(3):26084
Dual-modality immune nano-activator harnessing Mn(2)⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy.
Ma S, Zhang X, Zhu X, Yan K, Wang Q, Lei L, Li J, Guo J, Tang W, Liu J, Cao J, Wang D, Luo T
Journal of nanobiotechnology 2025 Mar 25;23(1):248
Journal of nanobiotechnology 2025 Mar 25;23(1):248
The activation of cGAS-STING pathway promotes the epithelial-mesenchymal transition and inflammation in intrauterine adhesion.
Wu X, He L, Lin Y, Zheng Y, Mao R, Hu J, Yuan R, Ge H
International immunopharmacology 2025 Jun 26;159:114840
International immunopharmacology 2025 Jun 26;159:114840
Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis.
Wang D, Liu C, Bao C, Hu J, Li Z, Ma X, Zhu Y, Xu S
Respiratory research 2025 Jun 21;26(1):219
Respiratory research 2025 Jun 21;26(1):219
Endogenous nanoplatforms for tumor photoimmunotherapy: Hypoxia modulation and STING pathway activation.
Yang Y, Shao N, Luo Q, Cheng N, Chen J, Huang Y, Huang C, Ouyang J, Luo L, Xiao Z
Acta biomaterialia 2025 Jun 1;199:398-411
Acta biomaterialia 2025 Jun 1;199:398-411
CSDE1 enhances genotoxic drug resistance in cancer by modulating RPA2 through CSDE1-eIF3a regulatory complex.
Cui JJ, Guo CX, Li J, Guo AX, Zhang Z, Li SY, Wang LY, Jia XB, Guo H, Xia K, Hu ZM, Ouyang QY, Wang Y, Xie YT, Liu ZQ, Zhang JT, Wu W, Chen YH, Yin JY
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jul;81:101249
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jul;81:101249
Epithelial Atg5 Deficiency Intensifies Caspase-11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS-STING-NLRP3 Axis in Macrophages During Pseudomonas Infection.
Wang J, Zhang L, Liu Y, Liu Y, Xiong A, Ran Q, He X, Wong VKW, Combs C, Li G, Wu M
MedComm 2025 Jul;6(7):e70239
MedComm 2025 Jul;6(7):e70239
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Yao M, Li P, Li X, Li W, Qian P
Veterinary research 2025 Jul 5;56(1):137
Veterinary research 2025 Jul 5;56(1):137
TSPAN7 inhibits pancreatic cancer progression by suppressing DNA double-strand break repair and enhances sensitivity to immunochemotherapy.
Lin H, Zhou J, Li Y, Luo L, Zeng Y, Liang X, Yu J, Ye C, Yang P, Lin Y, Li Y, Zeng L
Biochemical pharmacology 2025 Jul 30;242(Pt 1):117199
Biochemical pharmacology 2025 Jul 30;242(Pt 1):117199
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
Wu Y, Zhang Y, Yu Y, Wang X, Zhen Z, Yuan Y, Xie B, Han M, Wang M, Zhang X, Sun X, Wen X, Hashimoto K, Shang Y, Yuan S, Zhang J
Nature communications 2025 Jul 23;16(1):6779
Nature communications 2025 Jul 23;16(1):6779
XBP1 promotes endometrial fibrosis through cGAS-STING signaling pathway in intrauterine adhesion.
Wu X, He L, Lin Y, Zheng Y, Jiang P, Tian C, Mao R, Yang B, Shi Y, Ge H, Hu J, Yuan R
Scientific reports 2025 Jul 2;15(1):23299
Scientific reports 2025 Jul 2;15(1):23299
Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration.
Wu D, Yan C, Han L, Li F, Xu X, Sun J, Cao Y, Sun K, Shi J, Wang Y
Journal of nanobiotechnology 2025 Jul 14;23(1):510
Journal of nanobiotechnology 2025 Jul 14;23(1):510
Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo.
Jiang T, Zhu F, Gao X, Wu X, Zhu W, Guo C
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114343
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114343
Overexpression of FBP1 enhances dendritic cell activation and maturation by inhibiting glycolysis and promoting the secretion of IL33 in lung adenocarcinoma.
Li C, Zhu L, Yang Y, Zhang T, Chen C, Zhang Y, Ji W, Duan X, Xue W, Li L, Zhao J
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167559
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167559
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.
Liu Z, Bai Y, Xu B, Wen H, Chen K, Lin J, Wang Y, Xu J, Wang H, Shi F, Wang J, Wang H
Journal of neuroinflammation 2025 Jan 22;22(1):14
Journal of neuroinflammation 2025 Jan 22;22(1):14
Hesperidin enhanced anti-breast cancer effect and alleviated cisplatin induced nephrotoxicity through silk fibroin delivery system.
Jin Y, Dong N, Shimizu S, Li Y, Yao Y, Qiao H, Liu X, Liu S, Guo C, Wang L
Toxicology and applied pharmacology 2025 Feb;495:117234
Toxicology and applied pharmacology 2025 Feb;495:117234
Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the Ceruloplasmin/iron overload/mtDNA signaling pathway.
Ding T, Shen W, Tao W, Peng J, Pan M, Qi X, Feng W, Wei N, Zheng S, Jin H
The Journal of nutritional biochemistry 2025 Feb;136:109807
The Journal of nutritional biochemistry 2025 Feb;136:109807
USP34 regulates PIN1-cGAS-STING axis-dependent ferroptosis in cervical cancer via SUMOylation.
Liao D, Cui Y, Shi L, Zeng S, Wang H
International immunopharmacology 2025 Feb 6;147:113968
International immunopharmacology 2025 Feb 6;147:113968
Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling.
Xu ZY, Gao JS, He Y, Xiao XQ, Gong GZ, Zhang M
World journal of hepatology 2025 Feb 27;17(2):99292
World journal of hepatology 2025 Feb 27;17(2):99292
E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages.
Lu X, Liu C, Wu R, Hu Z, Liu S, Li X, Liu Y, Li M, Liang J, Huang Y, Han Y, Ou X, Deng K, Liang C, Chen S, Fu Y, Xu A
Cell reports 2025 Feb 25;44(2):115276
Cell reports 2025 Feb 25;44(2):115276
Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction.
Chen Q, Xiao Z, Ying X, Yang Y, Chen J, Wu Z, Zeng W, Miao C, Nan Y, Huang Q, Ai K
Bioactive materials 2025 Dec;54:777-796
Bioactive materials 2025 Dec;54:777-796
EXO/hydrogel system for sequential regulation of endogenous hyaline cartilage regeneration.
Wu K, Gong R, Gao T, Hu Y, Wang H, Zhang W, Wang X, Wang Y, Zhang N
Materials today. Bio 2025 Dec;35:102598
Materials today. Bio 2025 Dec;35:102598
Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury.
He S, Pan T, Tian R, He Q, Cheng D, Qu H, Li R, Tan R
Cell death and differentiation 2025 Dec;32(12):2177-2192
Cell death and differentiation 2025 Dec;32(12):2177-2192
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Cai D, Chen C, Meekrathok P, Zeng W, Wang Z, Peng Z, Mo Y, Xu X, Wang J, Qiu J
EMBO reports 2025 Dec;26(23):5959-5981
EMBO reports 2025 Dec;26(23):5959-5981
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Shu W, Chen G, Zhang J, Dong K, Zhou T, Cheng S, Zhang T, Zhang J, Li H, Yao Y, Yu S, Liu Y, Zhou X, Shen X, Wang H
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Cai T, Liang Z, Chen Z, Li Y, Xiao W, Liang W, Xie H, Liu H, Zeng Z, Yang X, Luo S, Zheng X, Zhong K, Huang L, Xiong L, Kang L
Autophagy 2025 Dec;21(12):2982-3003
Autophagy 2025 Dec;21(12):2982-3003
Paternal BDE-209 exposure disrupts spermatogenesis in mouse offspring via cGAS-STING pathway activation and mitophagy inhibition.
Xue J, Xie J, Li X, Gao L, Zhang Y, Zhang R, Zhao M, Zhang R, Wang H, Shi Z, Wei J, Zhou X
Journal of environmental sciences (China) 2025 Dec;158:137-150
Journal of environmental sciences (China) 2025 Dec;158:137-150
A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin.
Wang T, Gao Z, Guo C, Zhu W
International journal of pharmaceutics: X 2025 Dec;10:100389
International journal of pharmaceutics: X 2025 Dec;10:100389
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors.
Laliberté A, Prelli Bozzo C, Acharya D, De Luna A, Hirschenberger M, Zhu J, Volcic M, Stolp B, Rodriguez-Quinteros CM, Fackler OT, Gack MU, Sparrer KMJ, Kirchhoff F
Nature communications 2025 Dec 7;16(1):10945
Nature communications 2025 Dec 7;16(1):10945
Activation of the cGAS-STING pathway by clofoctol through mitochondrial damage in triple-negative breast cancer.
Wang L, Zheng L, Yong X, Ding Z, Sun J, Tang Y, Tang K, Li Y, Chen J, Qi S, Hu H, Tang H
Journal of translational medicine 2025 Dec 22;24(1):70
Journal of translational medicine 2025 Dec 22;24(1):70
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.
Fan PL, Lai HQ, Wang HY, Hu KC, Ruan Y, Ye JR, Wang SS, Peng Y, He WB, Li G, Yan X, Chu SF, Zhang Z, Chen NH
Cell death and differentiation 2025 Aug;32(8):1499-1517
Cell death and differentiation 2025 Aug;32(8):1499-1517
Integrated Proteomics Reveals Spliceosome Dysregulation and Highlights DHX9 as a TGF-β Signaling-Driven Fibrosis Hub in Endometriosis.
Yang M, Zhang L, Ding X, Wei P, Zhang H, Chen J, Zhang Y, Li D, Chen Z, Lin D, Huang Z, Chen Q
Journal of proteome research 2025 Aug 1;24(8):4044-4059
Journal of proteome research 2025 Aug 1;24(8):4044-4059
Hydrogen sulfide improves poststroke depression-induced inflammation in microglial cells by enhancing endoplasmic reticulum autophagy and inhibiting the cGAS-STING pathway.
Luo B, Xie Y, Kuang W, Wang Y, Chen G, Zhang Y, Yuan M
Neuroreport 2025 Apr 2;36(6):314-326
Neuroreport 2025 Apr 2;36(6):314-326
African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
Yao M, Cao H, Li W, Hu Z, Rong Z, Yin M, Tian L, Hu D, Li X, Qian P
Frontiers in immunology 2024;15:1380220
Frontiers in immunology 2024;15:1380220
GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline.
Mou L, Sun D, Qu J, Tan X, Wang S, Zeng Q, Liu C
Journal of hazardous materials 2024 Sep 5;476:135101
Journal of hazardous materials 2024 Sep 5;476:135101
SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B
bioRxiv : the preprint server for biology 2024 Sep 5;
bioRxiv : the preprint server for biology 2024 Sep 5;
Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis.
Zhu J, Zhao H, Aierken A, Zhou T, Menggen M, Gao H, He R, Aimulajiang K, Wen H
PLoS neglected tropical diseases 2024 Oct;18(10):e0012587
PLoS neglected tropical diseases 2024 Oct;18(10):e0012587
The relationship between tumor immunity and the cGAS-STING pathway in breast cancer: An immunohistochemical study.
Nishida H, Ohara N, Kato A, Kaimori R, Kondo Y, Kusaba T, Kadowaki H, Kawamura K, Daa T
Experimental and molecular pathology 2024 Oct;139:104917
Experimental and molecular pathology 2024 Oct;139:104917
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
Wang L, Zhang X, Huang X, Sha X, Li X, Zheng J, Li S, Wei Z, Wu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
Dronedarone hydrochloride (DH) induces pancreatic cancer cell death by triggering mtDNA-mediated pyroptosis.
Li MQ, He YQ, Zhang MN, Tang W, Tan Y, Cheng Y, Yang M, Zhao N, Li L, Yu SR, Li RL, Pan Q, Wu MY, Chai J
Cell death & disease 2024 Oct 2;15(10):725
Cell death & disease 2024 Oct 2;15(10):725
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells.
Shi W, Zhou Q, Lu L, Zhang Y, Zhang H, Pu Y, Yin L
Ecotoxicology and environmental safety 2024 Oct 15;285:117085
Ecotoxicology and environmental safety 2024 Oct 15;285:117085
A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice.
Zhao B, Wu H, Yao Q, Bai W, Kang J
Cell communication and signaling : CCS 2024 Nov 27;22(1):568
Cell communication and signaling : CCS 2024 Nov 27;22(1):568
cGAS regulates metabolic reprogramming independently of STING pathway in colorectal cancer.
Wang F, Jiang C, Hui HX, Tao MY, Wang HX, Sun Y, Zhu J
Experimental cell research 2024 Nov 1;443(1):114316
Experimental cell research 2024 Nov 1;443(1):114316
Pseudorabies virus usurps non-muscle myosin heavy chain IIA to dampen viral DNA recognition by cGAS for antagonism of host antiviral innate immunity.
Liu Y, Qin Y, Yang B, Zheng H, Qiao S, Luo Z, Li R
Journal of virology 2024 May 14;98(5):e0048324
Journal of virology 2024 May 14;98(5):e0048324
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Yang M, Gao L, Gao Y, Hao Z, Zhou X, Su G, Bai C, Wei Z, Liu X, Yang L, Li G
International journal of molecular sciences 2024 May 12;25(10)
International journal of molecular sciences 2024 May 12;25(10)
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613
Autophagy 2024 Mar;20(3):590-613
Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.
He Y, Yue J, Teng Y, Fan Z, Jia M, Teng H, Zhuge L
International immunopharmacology 2024 Mar 30;130:111687
International immunopharmacology 2024 Mar 30;130:111687
IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma.
Fu L, Ding H, Bai Y, Cheng L, Hu S, Guo Q
Heliyon 2024 Mar 15;10(5):e27205
Heliyon 2024 Mar 15;10(5):e27205
Comparison of Immunotherapy versus Targeted Therapy Effectiveness in BRAF-Mutant Melanoma Patients and Use of cGAS Expression and Aneuploidy as Potential Prognostic Biomarkers.
Garrison Z, Clister T, Bleem E, Berry EG, Kulkarni RP
Cancers 2024 Mar 1;16(5)
Cancers 2024 Mar 1;16(5)
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413
Virologica Sinica 2024 Jun;39(3):403-413
Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes.
Moadab F, Sohrabi S, Wang X, Najjar R, Wolters JC, Jiang H, Miao W, Romero D, Zaller DM, Tran M, Bays A, Taylor MS, Kapeller R, LaCava J, Mustelin T
Mobile DNA 2024 Jun 27;15(1):14
Mobile DNA 2024 Jun 27;15(1):14
Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling.
Zhang J, Du J, Liu D, Zhuo J, Chu L, Li Y, Gao L, Xu M, Chen W, Huang W, Xie L, Chen J, Meng X, Zou F, Cai S, Dong H
Ecotoxicology and environmental safety 2024 Jun 1;277:116357
Ecotoxicology and environmental safety 2024 Jun 1;277:116357
Enhancing myocardial infarction treatment through bionic hydrogel-mediated spatial combination therapy via mtDNA-STING crosstalk modulation.
Zheng Z, Sun J, Wang J, He S, Liu Z, Xie J, Yu CY, Wei H
Journal of controlled release : official journal of the Controlled Release Society 2024 Jul;371:570-587
Journal of controlled release : official journal of the Controlled Release Society 2024 Jul;371:570-587
Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.
Dong K, Sun Y, Gao X, Wang J, Wu X, Guo C
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113656
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113656
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
Liu Y, Duan R, Li P, Zhang B, Liu Y
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA.
Nie S, Zhang Z, Ji Y, Ding Q, Gong J, Xiao F, Chen L, Tian D, Liu M, Luo Z
Gut microbes 2024 Jan-Dec;16(1):2379633
Gut microbes 2024 Jan-Dec;16(1):2379633
Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.
Zhou S, Sun Y, Wang K, Gao X, Dong K, Wang J, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427
SUCNR 1 promotes atherosclerosis by inducing endoplasmic reticulum stress mediated ER-mito crosstalk.
Yuan C, Yu B, Li L, Chen J, Qin W, Zhou Z, Su M, Wang D, Zhang Y, Wu Q, He C, Wei D
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
International immunopharmacology 2024 Dec 25;143(Pt 3):113510
Neutrophil extracellular traps induce barrier dysfunction in DSS-induced ulcerative colitis via the cGAS-STING pathway.
Sun T, Wang P, Zhai X, Wang Z, Miao X, Yang Y, Wu J
International immunopharmacology 2024 Dec 25;143(Pt 1):113358
International immunopharmacology 2024 Dec 25;143(Pt 1):113358
The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disorders.
Jhanji M, Krall CL, Guevara A, Yoon B, Sajish M, Boccuto L, Lizarraga SB
bioRxiv : the preprint server for biology 2024 Dec 11;
bioRxiv : the preprint server for biology 2024 Dec 11;
Overexpression of ESYT3 improves radioimmune responses through activating cGAS-STING pathway in lung adenocarcinoma.
Luo Z, Li Y, Xu B, Yu T, Luo M, You P, Niu X, Li J
Experimental hematology & oncology 2024 Aug 5;13(1):77
Experimental hematology & oncology 2024 Aug 5;13(1):77
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.
He W, Chang H, Li C, Wang C, Li L, Yang G, Chen J, Liu H
Virology journal 2024 Aug 24;21(1):197
Virology journal 2024 Aug 24;21(1):197
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
Li W, Guo F, Zeng R, Liang H, Wang Y, Xiong W, Wu H, Yang C, Jin X
Cancer research 2024 Aug 15;84(16):2588-2606
Cancer research 2024 Aug 15;84(16):2588-2606
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654
Micronucleus is not a potent inducer of the cGAS/STING pathway.
Sato Y, Hayashi MT
Life science alliance 2024 Apr;7(4)
Life science alliance 2024 Apr;7(4)
Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS-STING signaling pathway.
Zhu W, Wang Y, Guan Y, Lu Y, Li Y, Sun L, Wang Y
Inflammopharmacology 2024 Apr;32(2):1113-1131
Inflammopharmacology 2024 Apr;32(2):1113-1131
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
Wang K, Wen Y, Fu X, Wei S, Liu S, Chen M
Free radical biology & medicine 2024 Apr;216:80-88
Free radical biology & medicine 2024 Apr;216:80-88
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T
Cell reports 2024 Apr 23;43(4):114088
Cell reports 2024 Apr 23;43(4):114088
Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.
Peng M, Li X, Zhang X, Peng L
Experimental lung research 2023;49(1):86-100
Experimental lung research 2023;49(1):86-100
Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing.
Yan Y, Wu L, Yuan Y, Wang H, Yin H, Li M, Chai L, Liang R, Liu Y, Zhao D, Xing J, Li P, Li X
PLoS pathogens 2023 Sep;19(9):e1011641
PLoS pathogens 2023 Sep;19(9):e1011641
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.
Yu Z, Zheng L, Geng Y, Zhang Y, Wang Y, You G, Cai M, Li M, Cheng X, Zan J
Cellular signalling 2023 Sep;109:110751
Cellular signalling 2023 Sep;109:110751
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
Ouyang W, Wang S, Yan D, Wu J, Zhang Y, Li W, Hu J, Liu Z
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Zhao C, Liang F, Ye M, Wu S, Qin Y, Zhao L, Zhang L, He J, Cen L, Lin F
Cell death discovery 2023 Oct 4;9(1):368
Cell death discovery 2023 Oct 4;9(1):368
Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells.
Liu Y, Yao X, Zhao Y, Fang D, Shi L, Yang L, Song G, Cai K, Li L, Deng Q, Li M, Luo Z
Cell reports 2023 Oct 31;42(10):113213
Cell reports 2023 Oct 31;42(10):113213
Low dose PFDA induces DNA damage and DNA repair inhibition by promoting nuclear cGAS accumulation in ovarian epithelial cells.
Qin Y, Yuan X, Cui Z, Chen W, Xu S, Chen K, Wang F, Zheng F, Ni H, Shen HM, Wu Y, Xia D
Ecotoxicology and environmental safety 2023 Oct 15;265:115503
Ecotoxicology and environmental safety 2023 Oct 15;265:115503
cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control.
Perumal N, White B, Sanchez-Valdez F, Tarleton RL
Journal of immunology (Baltimore, Md. : 1950) 2023 Oct 1;211(7):1123-1133
Journal of immunology (Baltimore, Md. : 1950) 2023 Oct 1;211(7):1123-1133
FEN1 inhibitor SC13 promotes CAR-T cells infiltration into solid tumours through cGAS-STING signalling pathway.
Dong Y, Wang Y, Yin X, Zhu H, Liu L, Zhang M, Chen J, Wang A, Huang T, Hu J, Liang J, Guo Z, He L
Immunology 2023 Nov;170(3):388-400
Immunology 2023 Nov;170(3):388-400
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Li LG, Yang XX, Xu HZ, Yu TT, Li QR, Hu J, Peng XC, Han N, Xu X, Chen NN, Chen X, Tang JM, Li TF
Advanced healthcare materials 2023 Nov;12(28):e2301561
Advanced healthcare materials 2023 Nov;12(28):e2301561
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.
Wang T, Liu W, Shen Q, Tao R, Li C, Shen Q, Lin Y, Huang Y, Yang L, Xie G, Bai J, Li R, Wang L, Tao K, Yin Y
Cancer science 2023 Nov;114(11):4184-4201
Cancer science 2023 Nov;114(11):4184-4201
A Bacterial mRNA-Lysis-Mediated Cargo Release Vaccine System for Regulated Cytosolic Surveillance and Optimized Antigen Delivery.
Li YA, Sun Y, Zhang Y, Li Q, Wang S, Curtiss R 3rd, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(33):e2303568
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(33):e2303568
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D
Nature communications 2023 Nov 30;14(1):7889
Nature communications 2023 Nov 30;14(1):7889
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ
Nature communications 2023 Nov 1;14(1):6770
Nature communications 2023 Nov 1;14(1):6770
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
Sun Z, Liu H, Hu Y, Luo G, Yuan Z, Tu B, Ruan H, Li J, Fan C
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
Ma Z, Bai J, Jiang C, Zhu H, Liu D, Pan M, Wang X, Pi J, Jiang P, Liu X
Autophagy 2023 May;19(5):1512-1532
Autophagy 2023 May;19(5):1512-1532
The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.
Zhou X, Zhang H, Jiang Y, Wei L, Chen Y, Zhang J, Gao P, Zhu S, Fang C, Du Y, Su R, He M, Yu J, Wang S, Ding W, Feng L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806
NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.
Zhao J, Zhen N, Zhou Q, Lou J, Cui W, Zhang G, Tian B
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
Qi J, Luo Q, Zhang Q, Wu M, Zhang L, Qin L, Xue Q, Nie X
Journal of ethnopharmacology 2023 Jun 12;309:116327
Journal of ethnopharmacology 2023 Jun 12;309:116327
Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.
Liu S, Gao X, Yin Y, Wang J, Dong K, Shi D, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113844
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113844
Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer.
Viculin J, Degoricija M, Vilović K, Gabela I, Franković L, Vrdoljak E, Korac-Prlic J
Cancers 2023 Jul 5;15(13)
Cancers 2023 Jul 5;15(13)
DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
Lou M, Huang D, Zhou Z, Shi X, Wu M, Rui Y, Su J, Zheng W, Yu XF
Journal of medical virology 2023 Jan;95(1):e28310
Journal of medical virology 2023 Jan;95(1):e28310
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
Li B, Wang W, Li Y, Wang S, Liu H, Xia Z, Gao W, Zhao B
Experimental neurology 2023 Jan;359:114269
Experimental neurology 2023 Jan;359:114269
Combination of STING agonist and CXCR3 antagonist disrupts immune tolerance to overcome anti-PD-L1 resistance in lung adenocarcinoma under oxidative stress.
Zhu L, Gao H, Huang S, Cao T, Zhai X, Hu J, Wang T, Dong J, Liu Z, Chen J, Liu J, Zhang Z, Zhou Q
Gene 2023 Jan 30;851:146962
Gene 2023 Jan 30;851:146962
Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS-STING Signaling Pathway.
Qi X, Wang J, Fei F, Gao X, Wu X, Shi D, Guo C
Molecular pharmaceutics 2023 Jan 2;20(1):136-146
Molecular pharmaceutics 2023 Jan 2;20(1):136-146
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Increasing expression of STING by ERα antagonizes LCN2 downregulation during chronic endometritis.
Chu M, He S, Zhao H, Yin S, Liu Z, Zhang W, Liu X, Bao H
Journal of reproductive immunology 2023 Dec;160:104167
Journal of reproductive immunology 2023 Dec;160:104167
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
Zhang G, Jiang P, Tang W, Wang Y, Qiu F, An J, Zheng Y, Wu D, Zhou J, Neculai D, Shi Y, Sheng W
Molecular cell 2023 Dec 7;83(23):4370-4385.e9
Molecular cell 2023 Dec 7;83(23):4370-4385.e9
RNF144A promotes antiviral responses by modulating STING ubiquitination.
Yang B, Pei J, Lu C, Wang Y, Shen M, Qin X, Huang Y, Yang X, Zhao X, Ma S, Song Z, Liang Y, Wang H, Wang J
EMBO reports 2023 Dec 6;24(12):e57528
EMBO reports 2023 Dec 6;24(12):e57528
SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1.
Li Y, Bie J, Song C, Li Y, Zhang T, Li H, Zhao L, You F, Luo J
EMBO reports 2023 Dec 6;24(12):e57500
EMBO reports 2023 Dec 6;24(12):e57500
Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling.
Jin Z, Shao Z, Yang S, Guo A, Han Y, Wu Y, Zhao Y, Wu Y, Shen J, Zhang M, Zhan X, Diao W, Ying S, Zhang C, Li W, Shen H, Chen Z, Yan F
Cell death & disease 2023 Dec 19;14(12):844
Cell death & disease 2023 Dec 19;14(12):844
Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer.
Shen Q, Yang L, Li C, Wang T, Lv J, Liu W, Lin Y, Yin Y, Tao K
Heliyon 2023 Aug;9(8):e18954
Heliyon 2023 Aug;9(8):e18954
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
Guan T, Li M, Song Y, Chen J, Tang J, Zhang C, Wen Y, Yang X, Huang L, Zhu Y, Wang H, Ding K, Zheng J, Zhang H, Liu T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205873
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205873
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Li J, Sun Y, Zhao X, Ma Y, Xie Y, Liu S, Hui B, Shi X, Sun X, Zhang X
Cell death & disease 2023 Apr 8;14(4):259
Cell death & disease 2023 Apr 8;14(4):259
Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.
Bai L, Dai J, Xia Y, He K, Xue H, Guo Q, Tian D, Xiao L, Zhang X, Teng X, Wu Y, Jin S
Oxidative medicine and cellular longevity 2022;2022:1392896
Oxidative medicine and cellular longevity 2022;2022:1392896
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Zhao X, Yu M, Zhao Y, Zheng Y, Meng L, Du K, Xie Z, Lv H, Zhang W, Liu J, Wang Q, Yuan Y, Wang Z, Deng J
Journal of neurology 2022 Sep;269(9):4985-4996
Journal of neurology 2022 Sep;269(9):4985-4996
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
Zhou M, Cheng X, Zhu W, Jiang J, Zhu S, Wu X, Liu M, Fang Q
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631
Baicalein-loaded silk fibroin peptide nanofibers protect against cisplatin-induced acute kidney injury: Fabrication, characterization and mechanism.
Liu S, Gao X, Wang Y, Wang J, Qi X, Dong K, Shi D, Wu X, Guo C
International journal of pharmaceutics 2022 Oct 15;626:122161
International journal of pharmaceutics 2022 Oct 15;626:122161
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.
Han C, Qian X, Ren X, Zhang S, Hu L, Li J, Huang Y, Huang R, Ooi K, Lin H, Xia C
Molecular neurobiology 2022 Nov;59(11):7006-7024
Molecular neurobiology 2022 Nov;59(11):7006-7024
Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.
Xu A, Yang R, Zhang M, Wang X, Di Y, Jiang B, Di Y, Zhou Z, Zhou L
Journal of drug targeting 2022 Nov;30(9):961-972
Journal of drug targeting 2022 Nov;30(9):961-972
Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity.
Kong Z, Yin H, Wang F, Liu Z, Luan X, Sun L, Liu W, Shang Y
PLoS pathogens 2022 May;18(5):e1010544
PLoS pathogens 2022 May;18(5):e1010544
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Shen R, Yang K, Cheng X, Guo C, Xing X, Sun H, Liu D, Liu X, Wang D
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response.
Geng X, Zhang C, Li M, Wang J, Ji F, Feng H, Xing M, Li F, Zhang L, Li W, Chen Z, Hickson ID, Shen H, Ying S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2103837
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2103837
Recruitment of DNA to tumor-derived microvesicles.
Clancy JW, Sheehan CS, Boomgarden AC, D'Souza-Schorey C
Cell reports 2022 Mar 1;38(9):110443
Cell reports 2022 Mar 1;38(9):110443
Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer.
Kunac N, Degoricija M, Viculin J, Omerović J, Terzić J, Vilović K, Korac-Prlic J
Cancers 2022 Dec 30;15(1)
Cancers 2022 Dec 30;15(1)
Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.
Xu Y, Yang Q, Xue B, Wang X, Tian R, Deng R, Chen S, Wang X, Wang L, Wang C, Chen J, You R, Liu Q, Li H, Wang J, Li X, Liu S, Yang D, Tang S, Zhu H
Journal of virology 2022 Apr 13;96(7):e0000122
Journal of virology 2022 Apr 13;96(7):e0000122
Activation of the cGAS-STING signaling pathway in adenomyosis patients.
Lin Y, Wang L, Ye M, Yu KN, Sun X, Xue M, Deng X
Immunity, inflammation and disease 2021 Sep;9(3):932-942
Immunity, inflammation and disease 2021 Sep;9(3):932-942
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Experimental eye research 2021 Jan;202:108366
Experimental eye research 2021 Jan;202:108366
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
Xu Q, Xiong H, Zhu W, Liu Y, Du Y
Life sciences 2020 Nov 1;260:118315
Life sciences 2020 Nov 1;260:118315
BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.
Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, Jiang DW, Du YK, Li XD, Zhang GP, Yang GY, Chu BB
PLoS pathogens 2020 Mar;16(3):e1008429
PLoS pathogens 2020 Mar;16(3):e1008429
Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation.
Han Y, Chen L, Liu H, Jin Z, Wu Y, Wu Y, Li W, Ying S, Chen Z, Shen H, Yan F
Journal of immunology (Baltimore, Md. : 1950) 2020 Mar 15;204(6):1437-1447
Journal of immunology (Baltimore, Md. : 1950) 2020 Mar 15;204(6):1437-1447
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136
mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection.
Meade N, King M, Munger J, Walsh D
Journal of virology 2019 Aug 1;93(15)
Journal of virology 2019 Aug 1;93(15)
IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.
Yang B, Song D, Liu Y, Cui Y, Lu G, Di W, Xing H, Ma L, Guo Z, Guan Y, Wang H, Wang J
FEBS letters 2018 May;592(10):1693-1704
FEBS letters 2018 May;592(10):1693-1704
Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.
Lum KK, Song B, Federspiel JD, Diner BA, Howard T, Cristea IM
Cell systems 2018 Dec 26;7(6):627-642.e6
Cell systems 2018 Dec 26;7(6):627-642.e6
Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.
Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D
Cell 2018 Aug 23;174(5):1143-1157.e17
Cell 2018 Aug 23;174(5):1143-1157.e17
HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation.
Wang J, Song D, Liu Y, Lu G, Yang S, Liu L, Gao Z, Ma L, Guo Z, Zhang C, Wang H, Yang B
Scientific reports 2017 Oct 31;7(1):14416
Scientific reports 2017 Oct 31;7(1):14416
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
Wang J, Kang L, Song D, Liu L, Yang S, Ma L, Guo Z, Ding H, Wang H, Yang B
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.
Bianco C, Mohr I
Journal of virology 2017 May 1;91(9)
Journal of virology 2017 May 1;91(9)
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