26416-1-AP

antibody from Proteintech Group

Targeting: CGAS C6orf150, MB21D1

Provider product page for 26416-1-AP

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Product number: 26416-1-AP - Provider product page
Provider: Proteintech Group
Product name: cGAS antibody
Antibody type: Polyclonal
Description: KD/KO validated cGAS antibody (Cat. #26416-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CGAS protein structure - 26416-1-AP shown in red.

Submitted references Pseudorabies virus usurps non-muscle myosin heavy chain IIA to dampen viral DNA recognition by cGAS for antagonism of host antiviral innate immunity.

Liu Y, Qin Y, Yang B, Zheng H, Qiao S, Luo Z, Li R
Journal of virology 2024 May 14;98(5):e0048324

CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.

Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613

Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.

He Y, Yue J, Teng Y, Fan Z, Jia M, Teng H, Zhuge L
International immunopharmacology 2024 Mar 30;130:111687

IDI1 inhibits the cGAS-Sting signaling pathway in hepatocellular carcinoma.

Fu L, Ding H, Bai Y, Cheng L, Hu S, Guo Q
Heliyon 2024 Mar 15;10(5):e27205

Comparison of Immunotherapy versus Targeted Therapy Effectiveness in BRAF-Mutant Melanoma Patients and Use of cGAS Expression and Aneuploidy as Potential Prognostic Biomarkers.

Garrison Z, Clister T, Bleem E, Berry EG, Kulkarni RP
Cancers 2024 Mar 1;16(5)

Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.

Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413

Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes.

Moadab F, Sohrabi S, Wang X, Najjar R, Wolters JC, Jiang H, Miao W, Romero D, Zaller DM, Tran M, Bays A, Taylor MS, Kapeller R, LaCava J, Mustelin T
Mobile DNA 2024 Jun 27;15(1):14

Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling.

Zhang J, Du J, Liu D, Zhuo J, Chu L, Li Y, Gao L, Xu M, Chen W, Huang W, Xie L, Chen J, Meng X, Zou F, Cai S, Dong H
Ecotoxicology and environmental safety 2024 Jun 1;277:116357

Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.

Dong K, Sun Y, Gao X, Wang J, Wu X, Guo C
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113656

3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.

Liu Y, Duan R, Li P, Zhang B, Liu Y
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041

Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.

Zhou S, Sun Y, Wang K, Gao X, Dong K, Wang J, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427

SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.

Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654

Micronucleus is not a potent inducer of the cGAS/STING pathway.

Sato Y, Hayashi MT
Life science alliance 2024 Apr;7(4)

Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS-STING signaling pathway.

Zhu W, Wang Y, Guan Y, Lu Y, Li Y, Sun L, Wang Y
Inflammopharmacology 2024 Apr;32(2):1113-1131

mtDNA regulates cGAS-STING signaling pathway in adenomyosis.

Wang K, Wen Y, Fu X, Wei S, Liu S, Chen M
Free radical biology & medicine 2024 Apr;216:80-88

IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.

Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T
Cell reports 2024 Apr 23;43(4):114088

Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.

Peng M, Li X, Zhang X, Peng L
Experimental lung research 2023;49(1):86-100

Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing.

Yan Y, Wu L, Yuan Y, Wang H, Yin H, Li M, Chai L, Liang R, Liu Y, Zhao D, Xing J, Li P, Li X
PLoS pathogens 2023 Sep;19(9):e1011641

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.

Yu Z, Zheng L, Geng Y, Zhang Y, Wang Y, You G, Cai M, Li M, Cheng X, Zan J
Cellular signalling 2023 Sep;109:110751

The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.

Ouyang W, Wang S, Yan D, Wu J, Zhang Y, Li W, Hu J, Liu Z
Signal transduction and targeted therapy 2023 Sep 21;8(1):371

GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.

Zhao C, Liang F, Ye M, Wu S, Qin Y, Zhao L, Zhang L, He J, Cen L, Lin F
Cell death discovery 2023 Oct 4;9(1):368

Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells.

Liu Y, Yao X, Zhao Y, Fang D, Shi L, Yang L, Song G, Cai K, Li L, Deng Q, Li M, Luo Z
Cell reports 2023 Oct 31;42(10):113213

Low dose PFDA induces DNA damage and DNA repair inhibition by promoting nuclear cGAS accumulation in ovarian epithelial cells.

Qin Y, Yuan X, Cui Z, Chen W, Xu S, Chen K, Wang F, Zheng F, Ni H, Shen HM, Wu Y, Xia D
Ecotoxicology and environmental safety 2023 Oct 15;265:115503

cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control.

Perumal N, White B, Sanchez-Valdez F, Tarleton RL
Journal of immunology (Baltimore, Md. : 1950) 2023 Oct 1;211(7):1123-1133

FEN1 inhibitor SC13 promotes CAR-T cells infiltration into solid tumours through cGAS-STING signalling pathway.

Dong Y, Wang Y, Yin X, Zhu H, Liu L, Zhang M, Chen J, Wang A, Huang T, Hu J, Liang J, Guo Z, He L
Immunology 2023 Nov;170(3):388-400

A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.

Li LG, Yang XX, Xu HZ, Yu TT, Li QR, Hu J, Peng XC, Han N, Xu X, Chen NN, Chen X, Tang JM, Li TF
Advanced healthcare materials 2023 Nov;12(28):e2301561

Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.

Wang T, Liu W, Shen Q, Tao R, Li C, Shen Q, Lin Y, Huang Y, Yang L, Xie G, Bai J, Li R, Wang L, Tao K, Yin Y
Cancer science 2023 Nov;114(11):4184-4201

A Bacterial mRNA-Lysis-Mediated Cargo Release Vaccine System for Regulated Cytosolic Surveillance and Optimized Antigen Delivery.

Li YA, Sun Y, Zhang Y, Li Q, Wang S, Curtiss R 3rd, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(33):e2303568

The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.

Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D
Nature communications 2023 Nov 30;14(1):7889

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.

Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ
Nature communications 2023 Nov 1;14(1):6770

STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.

Sun Z, Liu H, Hu Y, Luo G, Yuan Z, Tu B, Ruan H, Li J, Fan C
Clinical immunology (Orlando, Fla.) 2023 May;250:109300

Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.

Ma Z, Bai J, Jiang C, Zhu H, Liu D, Pan M, Wang X, Pi J, Jiang P, Liu X
Autophagy 2023 May;19(5):1512-1532

The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.

Zhou X, Zhang H, Jiang Y, Wei L, Chen Y, Zhang J, Gao P, Zhu S, Fang C, Du Y, Su R, He M, Yu J, Wang S, Ding W, Feng L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806

NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.

Zhao J, Zhen N, Zhou Q, Lou J, Cui W, Zhang G, Tian B
International journal of molecular sciences 2023 Mar 7;24(6)

Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.

Qi J, Luo Q, Zhang Q, Wu M, Zhang L, Qin L, Xue Q, Nie X
Journal of ethnopharmacology 2023 Jun 12;309:116327

Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.

Liu S, Gao X, Yin Y, Wang J, Dong K, Shi D, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113844

Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer.

Viculin J, Degoricija M, Vilović K, Gabela I, Franković L, Vrdoljak E, Korac-Prlic J
Cancers 2023 Jul 5;15(13)

DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.

Lou M, Huang D, Zhou Z, Shi X, Wu M, Rui Y, Su J, Zheng W, Yu XF
Journal of medical virology 2023 Jan;95(1):e28310

cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.

Li B, Wang W, Li Y, Wang S, Liu H, Xia Z, Gao W, Zhao B
Experimental neurology 2023 Jan;359:114269

Combination of STING agonist and CXCR3 antagonist disrupts immune tolerance to overcome anti-PD-L1 resistance in lung adenocarcinoma under oxidative stress.

Zhu L, Gao H, Huang S, Cao T, Zhai X, Hu J, Wang T, Dong J, Liu Z, Chen J, Liu J, Zhang Z, Zhou Q
Gene 2023 Jan 30;851:146962

Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS-STING Signaling Pathway.

Qi X, Wang J, Fei F, Gao X, Wu X, Shi D, Guo C
Molecular pharmaceutics 2023 Jan 2;20(1):136-146

TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.

Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79

Increasing expression of STING by ERα antagonizes LCN2 downregulation during chronic endometritis.

Chu M, He S, Zhao H, Yin S, Liu Z, Zhang W, Liu X, Bao H
Journal of reproductive immunology 2023 Dec;160:104167

CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.

Zhang G, Jiang P, Tang W, Wang Y, Qiu F, An J, Zheng Y, Wu D, Zhou J, Neculai D, Shi Y, Sheng W
Molecular cell 2023 Dec 7;83(23):4370-4385.e9

RNF144A promotes antiviral responses by modulating STING ubiquitination.

Yang B, Pei J, Lu C, Wang Y, Shen M, Qin X, Huang Y, Yang X, Zhao X, Ma S, Song Z, Liang Y, Wang H, Wang J
EMBO reports 2023 Dec 6;24(12):e57528

SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1.

Li Y, Bie J, Song C, Li Y, Zhang T, Li H, Zhao L, You F, Luo J
EMBO reports 2023 Dec 6;24(12):e57500

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling.

Jin Z, Shao Z, Yang S, Guo A, Han Y, Wu Y, Zhao Y, Wu Y, Shen J, Zhang M, Zhan X, Diao W, Ying S, Zhang C, Li W, Shen H, Chen Z, Yan F
Cell death & disease 2023 Dec 19;14(12):844

Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer.

Shen Q, Yang L, Li C, Wang T, Lv J, Liu W, Lin Y, Yin Y, Tao K
Heliyon 2023 Aug;9(8):e18954

Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.

Guan T, Li M, Song Y, Chen J, Tang J, Zhang C, Wen Y, Yang X, Huang L, Zhu Y, Wang H, Ding K, Zheng J, Zhang H, Liu T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205873

Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.

Li J, Sun Y, Zhao X, Ma Y, Xie Y, Liu S, Hui B, Shi X, Sun X, Zhang X
Cell death & disease 2023 Apr 8;14(4):259

Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.

Bai L, Dai J, Xia Y, He K, Xue H, Guo Q, Tian D, Xiao L, Zhang X, Teng X, Wu Y, Jin S
Oxidative medicine and cellular longevity 2022;2022:1392896

Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.

Zhao X, Yu M, Zhao Y, Zheng Y, Meng L, Du K, Xie Z, Lv H, Zhang W, Liu J, Wang Q, Yuan Y, Wang Z, Deng J
Journal of neurology 2022 Sep;269(9):4985-4996

Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.

Zhou M, Cheng X, Zhu W, Jiang J, Zhu S, Wu X, Liu M, Fang Q
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631

Baicalein-loaded silk fibroin peptide nanofibers protect against cisplatin-induced acute kidney injury: Fabrication, characterization and mechanism.

Liu S, Gao X, Wang Y, Wang J, Qi X, Dong K, Shi D, Wu X, Guo C
International journal of pharmaceutics 2022 Oct 15;626:122161

Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.

Han C, Qian X, Ren X, Zhang S, Hu L, Li J, Huang Y, Huang R, Ooi K, Lin H, Xia C
Molecular neurobiology 2022 Nov;59(11):7006-7024

Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.

Xu A, Yang R, Zhang M, Wang X, Di Y, Jiang B, Di Y, Zhou Z, Zhou L
Journal of drug targeting 2022 Nov;30(9):961-972

Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity.

Kong Z, Yin H, Wang F, Liu Z, Luan X, Sun L, Liu W, Shang Y
PLoS pathogens 2022 May;18(5):e1010544

Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.

Shen R, Yang K, Cheng X, Guo C, Xing X, Sun H, Liu D, Liu X, Wang D
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986

PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response.

Geng X, Zhang C, Li M, Wang J, Ji F, Feng H, Xing M, Li F, Zhang L, Li W, Chen Z, Hickson ID, Shen H, Ying S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2103837

Recruitment of DNA to tumor-derived microvesicles.

Clancy JW, Sheehan CS, Boomgarden AC, D'Souza-Schorey C
Cell reports 2022 Mar 1;38(9):110443

Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer.

Kunac N, Degoricija M, Viculin J, Omerović J, Terzić J, Vilović K, Korac-Prlic J
Cancers 2022 Dec 30;15(1)

Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection.

Xu Y, Yang Q, Xue B, Wang X, Tian R, Deng R, Chen S, Wang X, Wang L, Wang C, Chen J, You R, Liu Q, Li H, Wang J, Li X, Liu S, Yang D, Tang S, Zhu H
Journal of virology 2022 Apr 13;96(7):e0000122

Activation of the cGAS-STING signaling pathway in adenomyosis patients.

Lin Y, Wang L, Ye M, Yu KN, Sun X, Xue M, Deng X
Immunity, inflammation and disease 2021 Sep;9(3):932-942

The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.

Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Experimental eye research 2021 Jan;202:108366

Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.

Xu Q, Xiong H, Zhu W, Liu Y, Du Y
Life sciences 2020 Nov 1;260:118315

BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.

Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, Jiang DW, Du YK, Li XD, Zhang GP, Yang GY, Chu BB
PLoS pathogens 2020 Mar;16(3):e1008429

Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation.

Han Y, Chen L, Liu H, Jin Z, Wu Y, Wu Y, Li W, Ying S, Chen Z, Shen H, Yan F
Journal of immunology (Baltimore, Md. : 1950) 2020 Mar 15;204(6):1437-1447

Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.

Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM
The Journal of clinical investigation 2020 Jun 1;130(6):3124-3136

mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection.

Meade N, King M, Munger J, Walsh D
Journal of virology 2019 Aug 1;93(15)

IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.

Yang B, Song D, Liu Y, Cui Y, Lu G, Di W, Xing H, Ma L, Guo Z, Guan Y, Wang H, Wang J
FEBS letters 2018 May;592(10):1693-1704

Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS.

Lum KK, Song B, Federspiel JD, Diner BA, Howard T, Cristea IM
Cell systems 2018 Dec 26;7(6):627-642.e6

Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.

Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D
Cell 2018 Aug 23;174(5):1143-1157.e17

HLA-DMB restricts human T-cell leukemia virus type-1 (HTLV-1) protein expression via regulation of ATG7 acetylation.

Wang J, Song D, Liu Y, Lu G, Yang S, Liu L, Gao Z, Ma L, Guo Z, Zhang C, Wang H, Yang B
Scientific reports 2017 Oct 31;7(1):14416

Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.

Wang J, Kang L, Song D, Liu L, Yang S, Ma L, Guo Z, Ding H, Wang H, Yang B
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482

Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.

Bianco C, Mohr I
Journal of virology 2017 May 1;91(9)

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