orb66997

antibody from Biorbyt

Targeting: KDM1A AOF2, BHC110, KDM1, KIAA0601, LSD1

Western blot (Data presented on provider website)

Antibody Data

Product number

orb66997

Provider

Biorbyt

Product name

KDM1A antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal to KDM1A.Lysine-specific histone demethylase 1A (KDM1A) is a histone demethylase that demethylates both'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or acorepressor, depending on the context. KDM1A acts as a corepressor by mediating demethylation ofH3K4me, a specific tag for epigenetic transcriptional activation. KDM1A can demethylate both mono-(H3K4me1) and di-methylated (H3K4me2) H3K4me, and may play a role in the repression of neuronalgenes. KDM1A also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, bybeing recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag forepigenetic transcriptional repression. KDM1A is required for gastrulation during embryogenesis.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 ul

Storage

-20°C