Antibody data
- Antibody Data
- Antigen structure
- References [80]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10866-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10866-1-AP, RRID:AB_2257153
- Product name
- VDAC1/2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated VDAC1/2 antibody (Cat. #10866-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.
NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction.
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Walnut-Derived Peptide Activates PINK1 via the NRF2/KEAP1/HO-1 Pathway, Promotes Mitophagy, and Alleviates Learning and Memory Impairments in a Mice Model.
Novel NDUFA12 variants are associated with isolated complex I defect and variable clinical manifestation.
A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML).
Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis.
Gelsolin Governs the Neuroendocrine Transdifferentiation of Prostate Cancer Cells and Suppresses the Apoptotic Machinery.
DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.
Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNAThr Gene.
Complex I mutations synergize to worsen the phenotypic expression of Leber's hereditary optic neuropathy.
miR-103a-3p regulates mitophagy in Parkinson's disease through Parkin/Ambra1 signaling.
Mutant huntingtin does not cross the mitochondrial outer membrane.
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis.
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Activation of CaMKII via ER-stress mediates coxsackievirus B3-induced cardiomyocyte apoptosis.
NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis.
Estrogen receptors participate in silibinin-caused nuclear translocation of apoptosis-inducing factor in human breast cancer MCF-7 cells.
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Corilagin Alleviates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced C57BL/6 Mice by Ameliorating Oxidative Stress and Restoring Autophagic Flux.
Decreased expression of apoptosis-inducing factor in renal cell carcinoma is associated with poor prognosis and reduced postoperative survival.
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.
The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination.
Contribution of mitochondrial ND1 3394T>C mutation to the phenotypic manifestation of Leber's hereditary optic neuropathy.
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation.
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum.
Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation.
A novel iron(II) phenanthroline complex exhibits anticancer activity against TFR1-overexpressing esophageal squamous cell carcinoma cells through ROS accumulation and DNA damage.
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity.
Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment.
Mitochondrial dynamics and preconditioning in white matter.
Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex.
Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.
Picroside II Exerts a Neuroprotective Effect by Inhibiting mPTP Permeability and EndoG Release after Cerebral Ischemia/Reperfusion Injury in Rats.
Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease.
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.
Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway.
Esculetin induces apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-mediated mitochondrial pathways.
DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.
Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.
Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice.
Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats.
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
Inhibition of p66Shc-mediated mitochondrial apoptosis via targeting prolyl-isomerase Pin1 attenuates intestinal ischemia/reperfusion injury in rats.
Exercise Intolerance and Myoglobinuria Associated with a Novel Maternally Inherited MT-ND1 Mutation.
Induction of Apoptosis by the Nonstructural Protein 4 and 10 of Porcine Reproductive and Respiratory Syndrome Virus.
Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells.
Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation.
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Subcellular localization of DJ-1 in human HL-60 leukemia cells in response to diallyl disulfide treatment.
Proteomics-based identification of VDAC1 as a tumor promoter in cervical carcinoma.
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.
Sepsis-induced brain mitochondrial dysfunction is associated with altered mitochondrial Src and PTP1B levels.
α-Enolase plays a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunction.
CLPB variants associated with autosomal-recessive mitochondrial disorder with cataract, neutropenia, epilepsy, and methylglutaconic aciduria.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
The self-interaction of a nodavirus replicase is enhanced by mitochondrial membrane lipids.
The mitochondrial thioredoxin is required for liver development in zebrafish.
Blockade of PKCβ protects against remote organ injury induced by intestinal ischemia and reperfusion via a p66shc-mediated mitochondrial apoptotic pathway.
Novel distribution of calreticulin to cardiomyocyte mitochondria and its increase in a rat model of dilated cardiomyopathy.
Mitochondrial binding of α-enolase stabilizes mitochondrial membrane: its role in doxorubicin-induced cardiomyocyte apoptosis.
Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages.
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
Membrane association of Wuhan nodavirus protein A is required for its ability to accumulate genomic RNA1 template.
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.
Proteomic profiling of the 11-dehydrosinulariolide-treated oral carcinoma cells Ca9-22: effects on the cell apoptosis through mitochondrial-related and ER stress pathway.
Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening.
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.
Brustovetsky T, Khanna R, Brustovetsky N
Cells 2021 Oct 17;10(10)
Cells 2021 Oct 17;10(10)
NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction.
Tong D, Schiattarella GG, Jiang N, Altamirano F, Szweda PA, Elnwasany A, Lee DI, Yoo H, Kass DA, Szweda LI, Lavandero S, Verdin E, Gillette TG, Hill JA
Circulation research 2021 May 28;128(11):1629-1641
Circulation research 2021 May 28;128(11):1629-1641
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
Zhang Q, Wang Z, Chen X, Qiu H, Gu Y, Wang N, Wang T, Wang Z, Ma H, Zhao Y, Zhang B
International journal of molecular sciences 2021 May 24;22(11)
International journal of molecular sciences 2021 May 24;22(11)
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.
Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY, Lin SC
Nature cell biology 2021 Mar;23(3):268-277
Nature cell biology 2021 Mar;23(3):268-277
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Shangguan X, He J, Ma Z, Zhang W, Ji Y, Shen K, Yue Z, Li W, Xin Z, Zheng Q, Cao Y, Pan J, Dong B, Cheng J, Wang Q, Xue W
Nature communications 2021 Mar 22;12(1):1812
Nature communications 2021 Mar 22;12(1):1812
Walnut-Derived Peptide Activates PINK1 via the NRF2/KEAP1/HO-1 Pathway, Promotes Mitophagy, and Alleviates Learning and Memory Impairments in a Mice Model.
Zhao F, Liu C, Fang L, Lu H, Wang J, Gao Y, Gabbianelli R, Min W
Journal of agricultural and food chemistry 2021 Mar 10;69(9):2758-2772
Journal of agricultural and food chemistry 2021 Mar 10;69(9):2758-2772
Novel NDUFA12 variants are associated with isolated complex I defect and variable clinical manifestation.
Torraco A, Nasca A, Verrigni D, Pennisi A, Zaki MS, Olivieri G, Assouline Z, Martinelli D, Maroofian R, Rizza T, Di Nottia M, Invernizzi F, Lamantea E, Longo D, Houlden H, Prokisch H, Rötig A, Dionisi-Vici C, Bertini E, Ghezzi D, Carrozzo R, Diodato D
Human mutation 2021 Jun;42(6):699-710
Human mutation 2021 Jun;42(6):699-710
A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML).
Ando H, Murakami Y, Eshima K, Ishida T
Cancer reports (Hoboken, N.J.) 2021 Jun 26;:e1485
Cancer reports (Hoboken, N.J.) 2021 Jun 26;:e1485
Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076
Molecular nutrition & food research 2021 Jul;65(14):e2001076
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796
Life sciences 2021 Jan 15;265:118796
Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis.
Zheng M, Wu C, Yang K, Yang Y, Liu Y, Gao S, Wang Q, Li C, Chen L, Li H
Pharmacological research 2021 Feb;164:105367
Pharmacological research 2021 Feb;164:105367
Gelsolin Governs the Neuroendocrine Transdifferentiation of Prostate Cancer Cells and Suppresses the Apoptotic Machinery.
Oelrich F, Junker H, Stope MB, Erb HHH, Walther R, Venz S, Zimmermann U
Anticancer research 2021 Aug;41(8):3717-3729
Anticancer research 2021 Aug;41(8):3717-3729
DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.
Huang S, Li Z, Wu Z, Liu C, Yu M, Wen M, Zhang L, Wang X
Science signaling 2021 Apr 13;14(678)
Science signaling 2021 Apr 13;14(678)
Maternally Inherited Diabetes Mellitus Associated with a Novel m.15897G>A Mutation in Mitochondrial tRNAThr Gene.
Li K, Wu L, Liu J, Lin W, Qi Q, Zhao T
Journal of diabetes research 2020;2020:2057187
Journal of diabetes research 2020;2020:2057187
Complex I mutations synergize to worsen the phenotypic expression of Leber's hereditary optic neuropathy.
Ji Y, Zhang J, Lu Y, Yi Q, Chen M, Xie S, Mao X, Xiao Y, Meng F, Zhang M, Yang R, Guan MX
The Journal of biological chemistry 2020 Sep 18;295(38):13224-13238
The Journal of biological chemistry 2020 Sep 18;295(38):13224-13238
miR-103a-3p regulates mitophagy in Parkinson's disease through Parkin/Ambra1 signaling.
Zhou J, Zhao Y, Li Z, Zhu M, Wang Z, Li Y, Xu T, Feng D, Zhang S, Tang F, Yao J
Pharmacological research 2020 Oct;160:105197
Pharmacological research 2020 Oct;160:105197
Mutant huntingtin does not cross the mitochondrial outer membrane.
Hamilton J, Brustovetsky T, Khanna R, Brustovetsky N
Human molecular genetics 2020 Oct 10;29(17):2962-2975
Human molecular genetics 2020 Oct 10;29(17):2962-2975
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991
Cell death & disease 2020 Nov 17;11(11):991
Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis.
Wang N, Liu H, Liu G, Li M, He X, Yin C, Tu Q, Shen X, Bai W, Wang Q, Tao Y, Yin H
Redox biology 2020 May;32:101495
Redox biology 2020 May;32:101495
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Hua W, Li S, Luo R, Wu X, Zhang Y, Liao Z, Song Y, Wang K, Zhao K, Yang S, Yang C
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Activation of CaMKII via ER-stress mediates coxsackievirus B3-induced cardiomyocyte apoptosis.
Nie J, Ta N, Liu L, Shi G, Kang T, Zheng Z
Cell biology international 2020 Feb;44(2):488-498
Cell biology international 2020 Feb;44(2):488-498
NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis.
Zhao W, Zhang W, Ma H, Yang M
Scientific reports 2020 Feb 20;10(1):3078
Scientific reports 2020 Feb 20;10(1):3078
Estrogen receptors participate in silibinin-caused nuclear translocation of apoptosis-inducing factor in human breast cancer MCF-7 cells.
Liu W, Ji Y, Sun Y, Si L, Fu J, Hayashi T, Onodera S, Ikejima T
Archives of biochemistry and biophysics 2020 Aug 15;689:108458
Archives of biochemistry and biophysics 2020 Aug 15;689:108458
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Zhao Y, Wang Z, Feng D, Zhao H, Lin M, Hu Y, Zhang N, Lv L, Gao Z, Zhai X, Tian X, Yao J
Theranostics 2019;9(5):1510-1522
Theranostics 2019;9(5):1510-1522
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Chai N, Zhang H, Li L, Yu X, Liu Y, Lin Y, Wang L, Yan J, Nikolaevna SE, Zhao Y
Oxidative medicine and cellular longevity 2019;2019:5406468
Oxidative medicine and cellular longevity 2019;2019:5406468
Corilagin Alleviates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced C57BL/6 Mice by Ameliorating Oxidative Stress and Restoring Autophagic Flux.
Zhang R, Chu K, Zhao N, Wu J, Ma L, Zhu C, Chen X, Wei G, Liao M
Frontiers in pharmacology 2019;10:1693
Frontiers in pharmacology 2019;10:1693
Decreased expression of apoptosis-inducing factor in renal cell carcinoma is associated with poor prognosis and reduced postoperative survival.
Wang Z, Yuan C, Huang Y, Liu Z, Yu X, Lv C, Su Z
Oncology letters 2019 Sep;18(3):2805-2812
Oncology letters 2019 Sep;18(3):2805-2812
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
Violitzi F, Perivolidi VI, Thireou T, Grivas I, Haralambous S, Samiotaki M, Panayotou G, Douni E
Journal of proteome research 2019 Nov 1;18(11):3896-3912
Journal of proteome research 2019 Nov 1;18(11):3896-3912
A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.
Wang Y, Han T, Gan M, Guo M, Xie C, Jin J, Zhang S, Wang P, Cao J, Wang JB
Cell cycle (Georgetown, Tex.) 2019 May;18(9):1019-1032
Cell cycle (Georgetown, Tex.) 2019 May;18(9):1019-1032
The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination.
Liu C, Huang S, Wang X, Wen M, Zheng J, Wang W, Fu Y, Tian S, Li L, Li Z, Wang X
Journal of immunology (Baltimore, Md. : 1950) 2019 May 15;202(10):2957-2970
Journal of immunology (Baltimore, Md. : 1950) 2019 May 15;202(10):2957-2970
Contribution of mitochondrial ND1 3394T>C mutation to the phenotypic manifestation of Leber's hereditary optic neuropathy.
Ji Y, Zhang J, Yu J, Wang Y, Lu Y, Liang M, Li Q, Jin X, Wei Y, Meng F, Gao Y, Cang X, Tong Y, Liu X, Zhang M, Jiang P, Zhu T, Mo JQ, Huang T, Jiang P, Guan MX
Human molecular genetics 2019 May 1;28(9):1515-1529
Human molecular genetics 2019 May 1;28(9):1515-1529
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
Chen D, Zhang Z, Chen C, Yao S, Yang Q, Li F, He X, Ai C, Wang M, Guan MX
Nucleic acids research 2019 Jun 4;47(10):5341-5355
Nucleic acids research 2019 Jun 4;47(10):5341-5355
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H, Piao HL
iScience 2019 Jun 28;16:177-191
iScience 2019 Jun 28;16:177-191
JNK activation-mediated nuclear SIRT1 protein suppression contributes to silica nanoparticle-induced pulmonary damage via p53 acetylation and cytoplasmic localisation.
Zhao X, Wu Y, Li J, Li D, Jin Y, Zhu P, Liu Y, Zhuang Y, Yu S, Cao W, Wei H, Wang X, Han Y, Chen G
Toxicology 2019 Jul 1;423:42-53
Toxicology 2019 Jul 1;423:42-53
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, Luo O, Wang S, Wei J, Ding Y, Yu D
EBioMedicine 2019 Jan;39:239-254
EBioMedicine 2019 Jan;39:239-254
Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum.
Tang Z, Zhang Z, Zhang H, Wang Y, Zhang Y, Zhao J, Yang H, Wang Z
Cells 2019 Dec 27;9(1)
Cells 2019 Dec 27;9(1)
Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation.
Fan W, Zheng J, Kong W, Cui L, Aishanjiang M, Yi Q, Wang M, Cang X, Tang X, Chen Y, Mo JQ, Sondheimer N, Ge W, Guan MX
The Journal of biological chemistry 2019 Dec 13;294(50):19292-19305
The Journal of biological chemistry 2019 Dec 13;294(50):19292-19305
A novel iron(II) phenanthroline complex exhibits anticancer activity against TFR1-overexpressing esophageal squamous cell carcinoma cells through ROS accumulation and DNA damage.
Ye J, Ma J, Liu C, Huang J, Wang L, Zhong X
Biochemical pharmacology 2019 Aug;166:93-107
Biochemical pharmacology 2019 Aug;166:93-107
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity.
Wang Q, Ye S, Chen X, Xu P, Li K, Zeng S, Huang M, Gao W, Chen J, Zhang Q, Zhong Z, Liu Q
Biochemical and biophysical research communications 2019 Aug 6;515(4):517-523
Biochemical and biophysical research communications 2019 Aug 6;515(4):517-523
Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment.
Si L, Liu W, Hayashi T, Ji Y, Fu J, Nie Y, Mizuno K, Hattori S, Onodera S, Ikejima T
Archives of biochemistry and biophysics 2019 Aug 15;671:42-51
Archives of biochemistry and biophysics 2019 Aug 15;671:42-51
Mitochondrial dynamics and preconditioning in white matter.
Bastian C, Politano S, Day J, McCray A, Brunet S, Baltan S
Conditioning medicine 2018;1(2):64-72
Conditioning medicine 2018;1(2):64-72
Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex.
Micheva KD, Chang EF, Nana AL, Seeley WW, Ting JT, Cobbs C, Lein E, Smith SJ, Weinberg RJ, Madison DV
eNeuro 2018 Sep-Oct;5(5)
eNeuro 2018 Sep-Oct;5(5)
Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.
Cai J, Jiang Y, Zhang M, Zhao H, Li H, Li K, Zhang X, Qiao T
Journal of physiology and biochemistry 2018 May;74(2):335-343
Journal of physiology and biochemistry 2018 May;74(2):335-343
Picroside II Exerts a Neuroprotective Effect by Inhibiting mPTP Permeability and EndoG Release after Cerebral Ischemia/Reperfusion Injury in Rats.
Li S, Wang T, Zhai L, Ge K, Zhao J, Cong W, Guo Y
Journal of molecular neuroscience : MN 2018 Jan;64(1):144-155
Journal of molecular neuroscience : MN 2018 Jan;64(1):144-155
Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease.
Asano K, Suzuki T, Saito A, Wei FY, Ikeuchi Y, Numata T, Tanaka R, Yamane Y, Yamamoto T, Goto T, Kishita Y, Murayama K, Ohtake A, Okazaki Y, Tomizawa K, Sakaguchi Y, Suzuki T
Nucleic acids research 2018 Feb 28;46(4):1565-1583
Nucleic acids research 2018 Feb 28;46(4):1565-1583
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J
Cell research 2018 Aug;28(8):833-854
Cell research 2018 Aug;28(8):833-854
Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.
Grønborg S, Darin N, Miranda MJ, Damgaard B, Cayuela JA, Oldfors A, Kollberg G, Hansen TVO, Ravn K, Wibrand F, Østergaard E
JIMD reports 2017;33:69-77
JIMD reports 2017;33:69-77
Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1/PI3K/Akt signaling pathway.
Wang G, Lu M, Yao Y, Wang J, Li J
European journal of pharmacology 2017 Nov 5;814:207-215
European journal of pharmacology 2017 Nov 5;814:207-215
Esculetin induces apoptosis of SMMC-7721 cells through IGF-1/PI3K/Akt-mediated mitochondrial pathways.
Li J, Li S, Wang X, Wang H
Canadian journal of physiology and pharmacology 2017 Jul;95(7):787-794
Canadian journal of physiology and pharmacology 2017 Jul;95(7):787-794
DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.
Di Nottia M, Masciullo M, Verrigni D, Petrillo S, Modoni A, Rizzo V, Di Giuda D, Rizza T, Niceta M, Torraco A, Bianchi M, Santoro M, Bentivoglio AR, Bertini E, Piemonte F, Carrozzo R, Silvestri G
Clinical genetics 2017 Jul;92(1):18-25
Clinical genetics 2017 Jul;92(1):18-25
Quinocetone induces mitochondrial apoptosis in HepG2 cells through ROS-dependent promotion of VDAC1 oligomerization and suppression of Wnt1/β-catenin signaling pathway.
Yang X, Tang S, Dai C, Li D, Zhang S, Deng S, Zhou Y, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jul;105:161-176
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jul;105:161-176
Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice.
Li J, Chen K, Wang F, Dai W, Li S, Feng J, Wu L, Liu T, Xu S, Xia Y, Lu J, Zhou Y, Xu L, Guo C
Oncotarget 2017 Jul 11;8(28):45965-45980
Oncotarget 2017 Jul 11;8(28):45965-45980
Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats.
Kong X, Wei J, Wang D, Zhu X, Zhou Y, Wang S, Xu GY, Jiang GQ
Neuroscience bulletin 2017 Dec;33(6):711-721
Neuroscience bulletin 2017 Dec;33(6):711-721
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M
Cell systems 2017 Dec 27;5(6):564-577.e12
Cell systems 2017 Dec 27;5(6):564-577.e12
Inhibition of p66Shc-mediated mitochondrial apoptosis via targeting prolyl-isomerase Pin1 attenuates intestinal ischemia/reperfusion injury in rats.
Feng D, Yao J, Wang G, Li Z, Zu G, Li Y, Luo F, Ning S, Qasim W, Chen Z, Tian X
Clinical science (London, England : 1979) 2017 Apr 25;131(8):759-773
Clinical science (London, England : 1979) 2017 Apr 25;131(8):759-773
Exercise Intolerance and Myoglobinuria Associated with a Novel Maternally Inherited MT-ND1 Mutation.
Rafiq J, Duno M, Østergaard E, Ravn K, Vissing CR, Wibrand F, Vissing J
JIMD reports 2016;25:65-70
JIMD reports 2016;25:65-70
Induction of Apoptosis by the Nonstructural Protein 4 and 10 of Porcine Reproductive and Respiratory Syndrome Virus.
Yuan S, Zhang N, Xu L, Zhou L, Ge X, Guo X, Yang H
PloS one 2016;11(6):e0156518
PloS one 2016;11(6):e0156518
Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells.
Zhang T, Zhang Q, Guo J, Yuan H, Peng H, Cui L, Yin J, Zhang L, Zhao J, Li J, White A, Carmichael PL, Westmoreland C, Peng S
Environmental toxicology and pharmacology 2016 Sep;46:71-79
Environmental toxicology and pharmacology 2016 Sep;46:71-79
Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation.
Zheng X, Zhang Y, Zhang L, Xu W, Ma W, Sun R, Zeng H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:212-220
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:212-220
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Song G, Napoli E, Wong S, Hagerman R, Liu S, Tassone F, Giulivi C
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
Molecular medicine (Cambridge, Mass.) 2016 Oct;22:548-559
Subcellular localization of DJ-1 in human HL-60 leukemia cells in response to diallyl disulfide treatment.
Li Q, Tang Y, Qin J, Yi L, Yang Y, Wang J, He J, Su Q, Tan H
Molecular medicine reports 2016 Nov;14(5):4666-4672
Molecular medicine reports 2016 Nov;14(5):4666-4672
Proteomics-based identification of VDAC1 as a tumor promoter in cervical carcinoma.
Zhang C, Ding W, Liu Y, Hu Z, Zhu D, Wang X, Yu L, Wang L, Shen H, Zhang W, Ren C, Li K, Weng D, Deng W, Ma D, Wang H
Oncotarget 2016 Aug 9;7(32):52317-52328
Oncotarget 2016 Aug 9;7(32):52317-52328
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.
Zhang J, Chen K, Wang L, Wan X, Shrestha C, Zhou J, Mo Z
Biochemical and biophysical research communications 2016 Aug 5;476(4):299-305
Biochemical and biophysical research communications 2016 Aug 5;476(4):299-305
Sepsis-induced brain mitochondrial dysfunction is associated with altered mitochondrial Src and PTP1B levels.
Lyu J, Zheng G, Chen Z, Wang B, Tao S, Xiang D, Xie M, Huang J, Liu C, Zeng Q
Brain research 2015 Sep 16;1620:130-8
Brain research 2015 Sep 16;1620:130-8
α-Enolase plays a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunction.
Gao S, Li H, Feng XJ, Li M, Liu ZP, Cai Y, Lu J, Huang XY, Wang JJ, Li Q, Chen SR, Ye JT, Liu PQ
Journal of molecular and cellular cardiology 2015 Feb;79:92-103
Journal of molecular and cellular cardiology 2015 Feb;79:92-103
CLPB variants associated with autosomal-recessive mitochondrial disorder with cataract, neutropenia, epilepsy, and methylglutaconic aciduria.
Saunders C, Smith L, Wibrand F, Ravn K, Bross P, Thiffault I, Christensen M, Atherton A, Farrow E, Miller N, Kingsmore SF, Ostergaard E
American journal of human genetics 2015 Feb 5;96(2):258-65
American journal of human genetics 2015 Feb 5;96(2):258-65
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Liao H, Bao X, Zhu J, Qu J, Sun Y, Ma X, Wang E, Guo X, Kang Q, Zhen Y
Chemico-biological interactions 2015 Dec 5;242:91-8
Chemico-biological interactions 2015 Dec 5;242:91-8
The self-interaction of a nodavirus replicase is enhanced by mitochondrial membrane lipids.
Qiu Y, Wang Z, Liu Y, Han Y, Miao M, Qi N, Yang J, Xia H, Li X, Qin CF, Hu Y, Zhou X
PloS one 2014;9(2):e89628
PloS one 2014;9(2):e89628
The mitochondrial thioredoxin is required for liver development in zebrafish.
Zhang J, Cui X, Wang L, Liu F, Jiang T, Li C, Li D, Huang M, Liao S, Wang J, Chen J, Jia H, He J, Tang Z, Yin Z, Liu M
Current molecular medicine 2014;14(6):772-82
Current molecular medicine 2014;14(6):772-82
Blockade of PKCβ protects against remote organ injury induced by intestinal ischemia and reperfusion via a p66shc-mediated mitochondrial apoptotic pathway.
Wang G, Chen Z, Zhang F, Jing H, Xu W, Ning S, Li Z, Liu K, Yao J, Tian X
Apoptosis : an international journal on programmed cell death 2014 Sep;19(9):1342-53
Apoptosis : an international journal on programmed cell death 2014 Sep;19(9):1342-53
Novel distribution of calreticulin to cardiomyocyte mitochondria and its increase in a rat model of dilated cardiomyopathy.
Zhang M, Wei J, Li Y, Shan H, Yan R, Lin L, Zhang Q, Xue J
Biochemical and biophysical research communications 2014 Jun 20;449(1):62-8
Biochemical and biophysical research communications 2014 Jun 20;449(1):62-8
Mitochondrial binding of α-enolase stabilizes mitochondrial membrane: its role in doxorubicin-induced cardiomyocyte apoptosis.
Gao S, Li H, Cai Y, Ye JT, Liu ZP, Lu J, Huang XY, Feng XJ, Gao H, Chen SR, Li M, Liu PQ
Archives of biochemistry and biophysics 2014 Jan 15;542:46-55
Archives of biochemistry and biophysics 2014 Jan 15;542:46-55
Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages.
Chen H, Gao W, Yang Y, Guo S, Wang H, Wang W, Zhang S, Zhou Q, Xu H, Yao J, Tian Z, Li B, Cao W, Zhang Z, Tian Y
Apoptosis : an international journal on programmed cell death 2014 Dec;19(12):1712-26
Apoptosis : an international journal on programmed cell death 2014 Dec;19(12):1712-26
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
Liu C, Lin JJ, Yang ZY, Tsai CC, Hsu JL, Wu YJ
Journal of agricultural and food chemistry 2014 Dec 3;62(48):11672-80
Journal of agricultural and food chemistry 2014 Dec 3;62(48):11672-80
Membrane association of Wuhan nodavirus protein A is required for its ability to accumulate genomic RNA1 template.
Qiu Y, Wang Z, Liu Y, Qi N, Miao M, Si J, Xiang X, Cai D, Hu Y, Zhou X
Virology 2013 May 10;439(2):140-51
Virology 2013 May 10;439(2):140-51
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.
Sekigawa A, Fujita M, Sekiyama K, Takamatsu Y, Hatano T, Rockenstein E, La Spada AR, Masliah E, Hashimoto M
Molecular brain 2012 Sep 26;5:34
Molecular brain 2012 Sep 26;5:34
Proteomic profiling of the 11-dehydrosinulariolide-treated oral carcinoma cells Ca9-22: effects on the cell apoptosis through mitochondrial-related and ER stress pathway.
Liu CI, Wang RY, Lin JJ, Su JH, Chiu CC, Chen JC, Chen JY, Wu YJ
Journal of proteomics 2012 Oct 22;75(18):5578-89
Journal of proteomics 2012 Oct 22;75(18):5578-89
Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening.
Xu C, Yi C, Wang H, Bruce IC, Xia Q
Shock (Augusta, Ga.) 2012 Jan;37(1):110-5
Shock (Augusta, Ga.) 2012 Jan;37(1):110-5
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.
Su TR, Lin JJ, Chiu CC, Chen JY, Su JH, Cheng ZJ, Hwang WI, Huang HH, Wu YJ
Electrophoresis 2012 Apr;33(7):1139-52
Electrophoresis 2012 Apr;33(7):1139-52
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10866-1-AP(VDAC1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The VDAC1/Porin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VDAC1/Porin. This antibody recognizes human,mouse,rat antigen. The VDAC1/Porin antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-VDAC1 (IP:10866-1-AP, 3ug; Detection:10866-1-AP 1:1000) with mouse skeletal muscle tissue lysate 7500ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 10866-1-AP(VDAC1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue