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- Antigen structure
- References [138]
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- Immunohistochemistry [2]
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- Product number
- 55259-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55259-1-AP, RRID:AB_10837225
- Product name
- VDAC1/Porin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated VDAC1/Porin antibody (Cat. #55259-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references TMEM43 promotes the development of hepatocellular carcinoma by activating VDAC1 through USP7 deubiquitination.
Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.
APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.
6-Gingerol alleviates ectopic lipid deposition in skeletal muscle by regulating CD36 translocation and mitochondrial function.
CD47 blockade reduces ischemia/reperfusion injury in murine heart transplantation and improves donor heart preservation.
Alpha-ketoglutaric acid attenuates oxidative stress and modulates mitochondrial dynamics and autophagy of spleen in a piglet model of lipopolysaccharide-induced sepsis.
Non-cytopathic bovine viral diarrhea virus (BVDV) inhibits innate immune responses via induction of mitophagy.
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury.
Increased ROS levels in mitochondrial outer membrane protein Mul1-deficient oocytes result in abnormal preimplantation embryogenesis.
Parkin-mediated mitophagy is a potential treatment for oxaliplatin-induced peripheral neuropathy.
MicroRNA-129-1-3p protects chicken granulosa cells from cadmium-induced apoptosis by down-regulating the MCU-mediated Ca(2+) signaling pathway.
OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools.
Mitochondria-mediated ferroptosis contributes to the inflammatory responses of bovine viral diarrhea virus (BVDV) in vitro.
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits.
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway.
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction.
Establishment of Risk Model and Analysis of Immunoinfiltration Based on Mitophagy-Related Associated Genes in Atrial Fibrillation.
Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage.
Effect of Dl-3-n-butylphthalide on mitochondrial Cox7c in models of cerebral ischemia/reperfusion injury.
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Effects of DON on Mitochondrial Function, Endoplasmic Reticulum Stress, and Endoplasmic Reticulum Mitochondria Contact Sites in the Jejunum of Piglets.
MicroRNA-129-1-3p attenuates autophagy-dependent cell death by targeting MCU in granulosa cells of laying hens under H(2)O(2)-induced oxidative stress.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats.
Letter comments on: Google, ChatGPT and breast reconstruction.
Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1.
C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer.
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.
Sodium Sulfite-Triggered Hepatocyte Ferroptosis via mtROS/Lysosomal Membrane Permeabilization-Mediated Lysosome Iron Efflux.
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication.
Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.
Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway.
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
miR‑222-3p reduces neuronal cell apoptosis and alleviates spinal cord injury by inhibiting Bbc3 and Bim.
Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes.
Impaired mitophagy causes mitochondrial DNA leakage and STING activation in ultraviolet B-irradiated human keratinocytes HaCaT.
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.
Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Silencing of the mitochondrial ribosomal protein L-24 gene activates the oxidative stress response in Caenorhabditis elegans.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice.
HD-sEVs in bovine follicular fluid regulate granulosa cell apoptosis and estradiol secretion through the autophagy pathway.
VWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes.
The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication.
Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease.
The effects and mechanism of LncRNA NORAD on doxorubicin-induced cardiotoxicity.
Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury.
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice.
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells.
Hexokinase 2 Is a Pivot for Lovastatin-induced Glycolysis-to-Autophagy Reprogramming in Triple-Negative Breast Cancer Cells.
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke.
Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control.
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Identification of the Regulatory Targets of miR-3687 and miR-4417 in Prostate Cancer Cells Using a Proteomics Approach.
Mammary Fibrosis Tendency and Mitochondrial Adaptability in Dairy Cows with Mastitis.
Functional Attenuation of UCP1 as the Potential Mechanism for a Thickened Blubber Layer in Cetaceans.
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output.
sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin.
A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options.
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival.
Perfluorooctane sulfonate induces mitochondrial calcium overload and early hepatic insulin resistance via autophagy/detyrosinated alpha-tubulin-regulated IP3R2-VDAC1-MICU1 interaction.
Duck Tembusu virus infection induces mitochondrial-mediated and death receptor-mediated apoptosis in duck embryo fibroblasts.
H55 N variation in citrate synthase leads to decrement in the enzyme activity and transport rate to mitochondria in HEI-OC1 cells.
Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency.
Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases.
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.
Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity.
Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction.
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.
LncRNA HABON promoted liver cancer cells survival under hypoxia by inhibiting mPTP opening.
Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis.
Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis.
Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer.
Knockdown of VDAC1 alleviates the cognitive dysfunction secondary to sepsis-associated encephalopathy.
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice.
Galectin-7 overexpression destroys airway epithelial barrier in transgenic mice.
The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases.
Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.
Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes.
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.
Bioactivation of clozapine by mitochondria of the murine heart: Possible cause of cardiotoxicity.
Mtu1 defects are correlated with reduced osteogenic differentiation.
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D-TSG101 interactions.
Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
An Experimentally Induced Mutation in the UBA Domain of p62 Changes the Sensitivity of Cisplatin by Up-Regulating HK2 Localisation on the Mitochondria and Increasing Mitophagy in A2780 Ovarian Cancer Cells.
Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy.
miR-197-3p Represses the Proliferation of Prostate Cancer by Regulating the VDAC1/AKT/β-catenin Signaling Axis.
Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity.
KMT2A regulates cervical cancer cell growth through targeting VDAC1.
Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy.
Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues.
Increased Mitochondrial Fragmentation Mediated by Dynamin-Related Protein 1 Contributes to Hexavalent Chromium-Induced Mitochondrial Respiratory Chain Complex I-Dependent Cytotoxicity.
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
MiR-183-5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1.
Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea.
The protective effort of GPCR kinase 2-interacting protein-1 in neurons via promoting Beclin1-Parkin induced mitophagy at the early stage of spinal cord ischemia-reperfusion injury.
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca(2+)-ROS-Drp1-mitochondrial fission axis.
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.
Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells.
DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Exenatide Reduces Graft Injury in a Rat Transplantation Model Using Kidneys Donated after Cardiac Death.
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
A novel ent-kaurane diterpenoid analog, DN3, selectively kills human gastric cancer cells via acting directly on mitochondria.
Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.
Abnormal CYP11A1 gene expression induces excessive autophagy, contributing to the pathogenesis of preeclampsia.
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Neonatal mitochondrial hepatoencephalopathy caused by novel GFM1 mutations.
Zhang N, Wang F, Yang X, Wang Q, Chang R, Zhu L, Feitelson MA, Chen Z
Translational gastroenterology and hepatology 2024;9:9
Translational gastroenterology and hepatology 2024;9:9
Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.
Koma R, Shibaguchi T, Yamada T, Nonaka Y, Jue T, Yamazaki A, Masuda K
Acta physiologica (Oxford, England) 2024 May;240(5):e14139
Acta physiologica (Oxford, England) 2024 May;240(5):e14139
APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.
Zhao H, Cheng X, Yan L, Mi F, Wang W, Hu Y, Liu X, Fan Y, Min Q, Wang Y, Zhang W, Wu Q, Zhan Q
Cell communication and signaling : CCS 2024 May 23;22(1):283
Cell communication and signaling : CCS 2024 May 23;22(1):283
6-Gingerol alleviates ectopic lipid deposition in skeletal muscle by regulating CD36 translocation and mitochondrial function.
Peng Z, Zeng Y, Tan Q, He Q, Wang S, Wang J
Biochemical and biophysical research communications 2024 May 14;708:149786
Biochemical and biophysical research communications 2024 May 14;708:149786
CD47 blockade reduces ischemia/reperfusion injury in murine heart transplantation and improves donor heart preservation.
Li G, Chen J, Wang Z, Kang S, Liu Y, Ai X, Wang C, Jiang S
International immunopharmacology 2024 May 10;132:111953
International immunopharmacology 2024 May 10;132:111953
Alpha-ketoglutaric acid attenuates oxidative stress and modulates mitochondrial dynamics and autophagy of spleen in a piglet model of lipopolysaccharide-induced sepsis.
Liu G, Lu J, Sun W, Jia G, Zhao H, Chen X, Wang J
Free radical biology & medicine 2024 Mar;214:80-86
Free radical biology & medicine 2024 Mar;214:80-86
Non-cytopathic bovine viral diarrhea virus (BVDV) inhibits innate immune responses via induction of mitophagy.
Li Z, Zhang Y, Zhao B, Xue Q, Wang C, Wan S, Wang J, Chen X, Qi X
Veterinary research 2024 Mar 5;55(1):27
Veterinary research 2024 Mar 5;55(1):27
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.
Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Molecular cell 2024 Mar 21;84(6):1101-1119.e9
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
Li Y, Wang HB, Cao JL, Zhang WJ, Wang HL, Xu CH, Li KP, Liu Y, Wang JR, Ha HL, Fu SJ, Yang L
Journal of translational medicine 2024 Mar 10;22(1):261
Journal of translational medicine 2024 Mar 10;22(1):261
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury.
Hu C, Li M, Chen Y, Cheng W, Wang H, Zhou Y, Teng F, Ling T, Pan J, Xu H, Zheng Y, Ji G, Zhao T, You Q
Cell death discovery 2024 Mar 1;10(1):107
Cell death discovery 2024 Mar 1;10(1):107
Increased ROS levels in mitochondrial outer membrane protein Mul1-deficient oocytes result in abnormal preimplantation embryogenesis.
Nakai A, Fukushima Y, Yamamoto A, Amatsu Y, Chen X, Nishigori M, Yoshioka Y, Kaneko M, Koshiba T, Watanabe T
FEBS letters 2024 Jul;598(14):1740-1752
FEBS letters 2024 Jul;598(14):1740-1752
Parkin-mediated mitophagy is a potential treatment for oxaliplatin-induced peripheral neuropathy.
Zhao G, Zhang T, Li J, Li L, Chen P, Zhang C, Li K, Cui C
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C214-C228
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C214-C228
MicroRNA-129-1-3p protects chicken granulosa cells from cadmium-induced apoptosis by down-regulating the MCU-mediated Ca(2+) signaling pathway.
Zhu M, Yan M, Musa M, Li Y, Zhang Y, Zou X
Ecotoxicology and environmental safety 2024 Jan 1;269:115906
Ecotoxicology and environmental safety 2024 Jan 1;269:115906
OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools.
Lee A, Sung G, Shin S, Lee SY, Sim J, Nhung TTM, Nghi TD, Park SK, Sathieshkumar PP, Kang I, Mun JY, Kim JS, Rhee HW, Park KM, Kim K
Nature communications 2024 Feb 29;15(1):1851
Nature communications 2024 Feb 29;15(1):1851
Mitochondria-mediated ferroptosis contributes to the inflammatory responses of bovine viral diarrhea virus (BVDV) in vitro.
Li Z, Zhao B, Zhang Y, Fan W, Xue Q, Chen X, Wang J, Qi X
Journal of virology 2024 Feb 20;98(2):e0188023
Journal of virology 2024 Feb 20;98(2):e0188023
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294
Free radical biology & medicine 2024 Feb 20;212:284-294
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Gao C, Shang J, Sun Z, Xia M, Gao D, Sun R, Li W, Wang F, Zhang J
Molecular neurobiology 2024 Aug;61(8):5047-5070
Molecular neurobiology 2024 Aug;61(8):5047-5070
Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits.
Ding XY, Zhang H, Qiu YM, Xie MD, Wang H, Xiong ZY, Li TT, He CN, Dong W, Tang XL
Current medical science 2024 Apr;44(2):450-461
Current medical science 2024 Apr;44(2):450-461
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway.
Guan S, Qu X, Wang J, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114525
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114525
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Zhang H, Wang H, Hu Y, Gao Y, Chen J, Meng Y, Qiu Y, Hu R, Liao P, Li M, He Y, Liang Z, Xie X, Li Y
Cancer letters 2024 Apr 28;588:216802
Cancer letters 2024 Apr 28;588:216802
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
He Y, Jiang S, Cui Y, Liang J, Zhong Y, Sun Y, Moran MF, Huang Z, He G, Mao X
Cancer letters 2024 Apr 28;588:216797
Cancer letters 2024 Apr 28;588:216797
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction.
Guo P, Hu S, Liu X, He M, Li J, Ma T, Huang M, Fang Q, Wang Y
Journal of translational medicine 2024 Apr 26;22(1):390
Journal of translational medicine 2024 Apr 26;22(1):390
Establishment of Risk Model and Analysis of Immunoinfiltration Based on Mitophagy-Related Associated Genes in Atrial Fibrillation.
Sang W, Wang L, Yan X, Sun H, Han Y, Wang F, Tang B, Li Y
Journal of inflammation research 2023;16:2561-2583
Journal of inflammation research 2023;16:2561-2583
Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage.
Zeng J, Huang H, Zhang Y, Lv X, Cheng J, Zou SJ, Han Y, Wang S, Gong L, Peng Z
Frontiers in pharmacology 2023;14:1095487
Frontiers in pharmacology 2023;14:1095487
Effect of Dl-3-n-butylphthalide on mitochondrial Cox7c in models of cerebral ischemia/reperfusion injury.
Jia J, Deng J, Jin H, Yang J, Nan D, Yu Z, Yu W, Shen Z, Lu Y, Liu R, Wang Z, Qu X, Qiu D, Yang Z, Huang Y
Frontiers in pharmacology 2023;14:1084564
Frontiers in pharmacology 2023;14:1084564
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Liu Y, Zhang H, Liu Y, Zhang S, Su P, Wang L, Li Y, Liang Y, Wang X, Zhao W, Chen B, Luo D, Zhang N, Yang Q
Autophagy 2023 Sep;19(9):2443-2463
Autophagy 2023 Sep;19(9):2443-2463
Effects of DON on Mitochondrial Function, Endoplasmic Reticulum Stress, and Endoplasmic Reticulum Mitochondria Contact Sites in the Jejunum of Piglets.
Li X, Gou F, Xiao K, Zhu J, Lin Q, Yu M, Hong Q, Hu C
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13234-13243
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13234-13243
MicroRNA-129-1-3p attenuates autophagy-dependent cell death by targeting MCU in granulosa cells of laying hens under H(2)O(2)-induced oxidative stress.
Zhu M, Yan M, Chen J, Li H, Zhang Y
Poultry science 2023 Oct;102(10):103006
Poultry science 2023 Oct;102(10):103006
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats.
Fusagawa H, Sato T, Yamada T, Ashida Y, Kimura I, Naito A, Tokuda N, Yamauchi N, Ichise N, Terashima Y, Ogon I, Teramoto A, Yamashita T, Tohse N
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Oct 1;135(4):731-746
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Oct 1;135(4):731-746
Letter comments on: Google, ChatGPT and breast reconstruction.
Kleebayoon A, Wiwanitkit V
Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2023 Nov;86:269-270
Journal of plastic, reconstructive & aesthetic surgery : JPRAS 2023 Nov;86:269-270
Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1.
Hu T, Zou HX, Le SY, Wang YR, Qiao YM, Yuan Y, Liu JC, Lai SQ, Huang H
International journal of molecular medicine 2023 Nov;52(5)
International journal of molecular medicine 2023 Nov;52(5)
C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer.
Wang H, Liang Y, Zhang T, Yu X, Song X, Chen Y, Mao Q, Xia W, Chen B, Xu L, Dong G, Jiang F
Cell death and differentiation 2023 Nov;30(11):2365-2381
Cell death and differentiation 2023 Nov;30(11):2365-2381
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.
Zhou J, Meng L, He Z, Song Q, Liu J, Su X, Wang C, Ke H, Dong C, Liao W, Yang S
International immunopharmacology 2023 Nov;124(Pt A):110801
International immunopharmacology 2023 Nov;124(Pt A):110801
Sodium Sulfite-Triggered Hepatocyte Ferroptosis via mtROS/Lysosomal Membrane Permeabilization-Mediated Lysosome Iron Efflux.
Liu M, Lu J, Chen Y, Zhang S, Guo J, Guan S
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16310-16322
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16310-16322
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication.
Fu J, Liu G, Zhang X, Lei X, Liu Q, Qian K, Tong Q, Qin W, Li Z, Cao Z, Zhang J, Liu C, Wang Z, Liu Z, Liang XM, Yamamoto H, Xu X
Cancer gene therapy 2023 May;30(5):738-751
Cancer gene therapy 2023 May;30(5):738-751
Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.
Yan G, Yang J, Li W, Guo A, Guan J, Liu Y
Nature cell biology 2023 May;25(5):754-764
Nature cell biology 2023 May;25(5):754-764
Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway.
Cai X, Zhu S
Genomics 2023 May;115(3):110595
Genomics 2023 May;115(3):110595
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Wang Y, Miao Z, Xu C, Cai Y, Yang Y, Hu Y, Zhao M, Shao Y, Li Z, Chen J, Chen S, Wang L
Cell death & disease 2023 May 13;14(5):325
Cell death & disease 2023 May 13;14(5):325
miR‑222-3p reduces neuronal cell apoptosis and alleviates spinal cord injury by inhibiting Bbc3 and Bim.
Zhang Q, Li G, Kong J, Dai J, Fan Z, Li J
Neuroscience research 2023 Mar;188:39-50
Neuroscience research 2023 Mar;188:39-50
Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes.
Li J, Hui Y, Xu Z, Tan J, Yin K, Kuang L, Tang Y, Wei J, Zhong Q, Zheng T
iScience 2023 Mar 17;26(3):106271
iScience 2023 Mar 17;26(3):106271
Impaired mitophagy causes mitochondrial DNA leakage and STING activation in ultraviolet B-irradiated human keratinocytes HaCaT.
Li C, Zhu Y, Liu W, Xiang W, He S, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Archives of biochemistry and biophysics 2023 Mar 15;737:109553
Archives of biochemistry and biophysics 2023 Mar 15;737:109553
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.
Yang C, Zhao Y, Wang L, Guo Z, Ma L, Yang R, Wu Y, Li X, Niu J, Chu Q, Fu Y, Li B
Nature cell biology 2023 Jun;25(6):836-847
Nature cell biology 2023 Jun;25(6):836-847
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.
Liang JP, He YM, Cui YL, Sun YN, He GS, Zhu ZG, Mao XL
Acta pharmacologica Sinica 2023 Jul;44(7):1464-1474
Acta pharmacologica Sinica 2023 Jul;44(7):1464-1474
Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.
Yao Y, Bade R, Li G, Zhang A, Zhao H, Fan L, Zhu R, Yuan J
Cellular and molecular neurobiology 2023 Jul;43(5):1989-2004
Cellular and molecular neurobiology 2023 Jul;43(5):1989-2004
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Chang Y, Wang C, Zhu J, Zheng S, Sun S, Wu Y, Jiang X, Li L, Ma R, Li G
Journal of translational medicine 2023 Jul 22;21(1):494
Journal of translational medicine 2023 Jul 22;21(1):494
Silencing of the mitochondrial ribosomal protein L-24 gene activates the oxidative stress response in Caenorhabditis elegans.
Ficociello G, Schifano E, Di Nottia M, Torraco A, Carrozzo R, Uccelletti D, Montanari A
Biochimica et biophysica acta. General subjects 2023 Jan;1867(1):130255
Biochimica et biophysica acta. General subjects 2023 Jan;1867(1):130255
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS
Archives of toxicology 2023 Dec;97(12):3209-3226
Archives of toxicology 2023 Dec;97(12):3209-3226
Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice.
Iida R, Ueki M, Yasuda T
Transgenic research 2023 Dec;32(6):575-582
Transgenic research 2023 Dec;32(6):575-582
HD-sEVs in bovine follicular fluid regulate granulosa cell apoptosis and estradiol secretion through the autophagy pathway.
Wang Y, Zhao Y, Ling Z, Luan D, Kang J, Dong X, Quan F
Theriogenology 2023 Dec;212:91-103
Theriogenology 2023 Dec;212:91-103
VWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes.
Zhao T, Guan Y, Xu C, Wang D, Guan J, Liu Y
Nature communications 2023 Dec 20;14(1):8464
Nature communications 2023 Dec 20;14(1):8464
The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication.
Zhang S, Zeng L, Su B-Q, Yang G-Y, Wang J, Ming S-L, Chu B-B
mBio 2023 Dec 19;14(6):e0265123
mBio 2023 Dec 19;14(6):e0265123
Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease.
Shi J, Wang W, Sun S, Xu X, Fei J, Zhou Q, Qin C, Ou S, Wu F, Wu FT, Xu T, Bai L, Xie F
iScience 2023 Aug 18;26(8):107312
iScience 2023 Aug 18;26(8):107312
The effects and mechanism of LncRNA NORAD on doxorubicin-induced cardiotoxicity.
Guan X, Wang Y, Li W, Liu X, Jiang J, Bian W, Xu C, Sun Y, Zhang C
Toxicology 2023 Aug 1;494:153587
Toxicology 2023 Aug 1;494:153587
Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury.
Wan H, Yan YD, Hu XM, Shang L, Chen YH, Huang YX, Zhang Q, Yan WT, Xiong K
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2023 Apr;247:152049
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2023 Apr;247:152049
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Koma R, Shibaguchi T, Araiso Y, Yamada T, Nonaka Y, Jue T, Masuda K
Physiological reports 2023 Apr;11(7):e15632
Physiological reports 2023 Apr;11(7):e15632
Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice.
Panes J, Nguyen TKO, Gao H, Christensen TA, Stojakovic A, Trushin S, Salisbury JL, Fuentealba J, Trushina E
Cells 2023 Apr 8;12(8)
Cells 2023 Apr 8;12(8)
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells.
Huang W, Mao L, Xie W, Cai S, Huang Q, Liu Y, Chen Z
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2022;39(1):287-296
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2022;39(1):287-296
Hexokinase 2 Is a Pivot for Lovastatin-induced Glycolysis-to-Autophagy Reprogramming in Triple-Negative Breast Cancer Cells.
Xue L, Wu M, Li Y, Chen S, Wu M, Zhu J, Ding S, Zhang Q, Zheng C, He G, Fu S, Li G, Deng X
Journal of Cancer 2022;13(12):3368-3377
Journal of Cancer 2022;13(12):3368-3377
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke.
Huang W, Xie W, Zhong H, Cai S, Huang Q, Liu Y, Zeng Z, Liu Y
Frontiers in immunology 2022;13:859231
Frontiers in immunology 2022;13:859231
Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control.
Yan M, Jin S, Liu Y, Wang L, Wang Z, Xia T, Chang Q
Frontiers in pharmacology 2022;13:824138
Frontiers in pharmacology 2022;13:824138
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Peng Y, Liao K, Tan F, Liang Y, Sun X, Cui Z, Ye B, Chen Z, Tang S, Chen J
Experimental eye research 2022 Sep;222:109158
Experimental eye research 2022 Sep;222:109158
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Wang L, Yang Z, Wang S, Que Y, Shu X, Wu F, Liu G, Li S, Hu P, Chen H, Shi J, Tong X
British journal of pharmacology 2022 Sep;179(17):4423-4439
British journal of pharmacology 2022 Sep;179(17):4423-4439
Identification of the Regulatory Targets of miR-3687 and miR-4417 in Prostate Cancer Cells Using a Proteomics Approach.
Venz S, Junker H, Ultsch E, Hetke F, Krüger E, Burchardt M, Caetano-Pinto P, Roennau C
International journal of molecular sciences 2022 Sep 12;23(18)
International journal of molecular sciences 2022 Sep 12;23(18)
Mammary Fibrosis Tendency and Mitochondrial Adaptability in Dairy Cows with Mastitis.
Kan X, Hu G, Liu Y, Xu P, Huang Y, Cai X, Guo W, Fu S, Liu J
Metabolites 2022 Oct 28;12(11)
Metabolites 2022 Oct 28;12(11)
Functional Attenuation of UCP1 as the Potential Mechanism for a Thickened Blubber Layer in Cetaceans.
Zhou M, Wu T, Chen Y, Xu S, Yang G
Molecular biology and evolution 2022 Nov 3;39(11)
Molecular biology and evolution 2022 Nov 3;39(11)
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
Bussi C, Heunis T, Pellegrino E, Bernard EM, Bah N, Dos Santos MS, Santucci P, Aylan B, Rodgers A, Fearns A, Mitschke J, Moore C, MacRae JI, Greco M, Reinheckel T, Trost M, Gutierrez MG
Nature communications 2022 Nov 28;13(1):7338
Nature communications 2022 Nov 28;13(1):7338
CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output.
Zheng H, Huang S, Wei G, Sun Y, Li C, Si X, Chen Y, Tang Z, Li X, Chen Y, Liao W, Liao Y, Bin J
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Nov 2;30(11):3477-3498
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Nov 2;30(11):3477-3498
sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
Zhu L, Li B, Chen D, Chen N, Xu L, Li Q, Chen X
Life sciences 2022 May 1;296:120438
Life sciences 2022 May 1;296:120438
p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin.
Kong Q, Yan X, Cheng M, Jiang X, Xu L, Shen L, Yu H, Sun L
International journal of molecular sciences 2022 Mar 18;23(6)
International journal of molecular sciences 2022 Mar 18;23(6)
A novel COQ7 mutation causing primarily neuromuscular pathology and its treatment options.
Wang Y, Gumus E, Hekimi S
Molecular genetics and metabolism reports 2022 Jun;31:100877
Molecular genetics and metabolism reports 2022 Jun;31:100877
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival.
Song Y, Ge X, Chen Y, Hussain T, Liang Z, Dong Y, Wang Y, Tang C, Zhou X
Autophagy 2022 Jun;18(6):1401-1415
Autophagy 2022 Jun;18(6):1401-1415
Perfluorooctane sulfonate induces mitochondrial calcium overload and early hepatic insulin resistance via autophagy/detyrosinated alpha-tubulin-regulated IP3R2-VDAC1-MICU1 interaction.
Dong Z, Wang J, Qiu T, Wu J, An Y, Shi X, Sun X, Jiang L, Liu X, Yang G, Cao J, Yao X
The Science of the total environment 2022 Jun 15;825:153933
The Science of the total environment 2022 Jun 15;825:153933
Duck Tembusu virus infection induces mitochondrial-mediated and death receptor-mediated apoptosis in duck embryo fibroblasts.
Pan Y, Cai W, Cheng A, Wang M, Chen S, Huang J, Yang Q, Wu Y, Sun D, Mao S, Zhu D, Liu M, Zhao X, Zhang S, Gao Q, Ou X, Tian B, Yin Z, Jia R
Veterinary research 2022 Jul 7;53(1):53
Veterinary research 2022 Jul 7;53(1):53
H55 N variation in citrate synthase leads to decrement in the enzyme activity and transport rate to mitochondria in HEI-OC1 cells.
Li Z, Liu R, Liu Y, Zhao M, Luan J, Wang Y, Shang W, Song X, Sun Y, Han F
Biochemical and biophysical research communications 2022 Jul 5;612:134-140
Biochemical and biophysical research communications 2022 Jul 5;612:134-140
Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency.
Sun X, Dong S, Kato H, Kong J, Ito Y, Hirofuji Y, Sato H, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K
Antioxidants (Basel, Switzerland) 2022 Jul 13;11(7)
Antioxidants (Basel, Switzerland) 2022 Jul 13;11(7)
Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases.
Fu J, Zhou M, Gritsenko MA, Nakayasu ES, Song L, Luo ZQ
eLife 2022 Jan 27;11
eLife 2022 Jan 27;11
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
Bryant JD, Lei Y, VanPortfliet JJ, Winters AD, West AP
Current protocols 2022 Feb;2(2):e372
Current protocols 2022 Feb;2(2):e372
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.
Gao M, Yang Y, Gao Y, Liu T, Guan Q, Zhou T, Shi Y, Hao M, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2022 Feb 25;354:109843
Chemico-biological interactions 2022 Feb 25;354:109843
Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity.
Zhao P, Jin Y, Wu X, Huang J, Chen L, Tan Y, Yuan H, Wu J, Ren Z
Nanomaterials (Basel, Switzerland) 2022 Feb 17;12(4)
Nanomaterials (Basel, Switzerland) 2022 Feb 17;12(4)
Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction.
Wu D, Tan B, Sun Y, Hu Q
Redox biology 2022 Dec;58:102519
Redox biology 2022 Dec;58:102519
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Yan G, Li X, Zheng Z, Gao W, Chen C, Wang X, Cheng Z, Yu J, Zou G, Farooq MZ, Zhu X, Zhu W, Zhong Q, Yan X
Autophagy 2022 Dec;18(12):2799-2816
Autophagy 2022 Dec;18(12):2799-2816
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.
Zhou H, Zhuang W, Huang H, Ma N, Lei J, Jin G, Wu S, Zhou S, Zhao X, Lan L, Xia H, Shangguan F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154428
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154428
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Fu J, Yu S, Zhao X, Zhang C, Shen L, Liu Y, Yu H
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Zhang S, Wu X, Wang J, Shi Y, Hu Q, Cui W, Bai H, Zhou J, Du Y, Han L, Li L, Feng D, Ge S, Qu Y
Redox biology 2022 Aug;54:102390
Redox biology 2022 Aug;54:102390
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.
Weindel CG, Martinez EL, Zhao X, Mabry CJ, Bell SL, Vail KJ, Coleman AK, VanPortfliet JJ, Zhao B, Wagner AR, Azam S, Scott HM, Li P, West AP, Karpac J, Patrick KL, Watson RO
Cell 2022 Aug 18;185(17):3214-3231.e23
Cell 2022 Aug 18;185(17):3214-3231.e23
LncRNA HABON promoted liver cancer cells survival under hypoxia by inhibiting mPTP opening.
Wo L, Zhang X, Ma C, Zhou C, Li J, Hu Z, Gong X, Zhan M, He M, Zhao Q
Cell death discovery 2022 Apr 6;8(1):171
Cell death discovery 2022 Apr 6;8(1):171
Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J, Zou Y
International journal of molecular sciences 2022 Apr 28;23(9)
International journal of molecular sciences 2022 Apr 28;23(9)
Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis.
Yang L, Tao Y, Luo L, Zhang Y, Wang X, Meng X
Journal of ethnopharmacology 2022 Apr 24;288:114988
Journal of ethnopharmacology 2022 Apr 24;288:114988
Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer.
Zhen Y, Yuan Z, Zhang J, Chen Y, Fu Y, Liu Y, Fu L, Zhang L, Zhou XL
Cell death & disease 2022 Apr 19;13(4):375
Cell death & disease 2022 Apr 19;13(4):375
Knockdown of VDAC1 alleviates the cognitive dysfunction secondary to sepsis-associated encephalopathy.
Cai M, Du B, Si Y, Miao J, Ge J, Zhang J, Song J, Bao H
American journal of translational research 2021;13(7):7538-7555
American journal of translational research 2021;13(7):7538-7555
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
Li Q, Deng Y, Liu L, Zhang C, Cai Y, Zhang T, Han M, Xu G
Frontiers in immunology 2021;12:823935
Frontiers in immunology 2021;12:823935
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Chu BX, Li YN, Liu N, Yuan LX, Chen SY, Zhu YH, Wang JF
Frontiers in immunology 2021;12:757909
Frontiers in immunology 2021;12:757909
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Sun J, Chen W, Li S, Yang S, Zhang Y, Hu X, Qiu H, Wu J, Xu S, Chu T
Frontiers in pharmacology 2021;12:751845
Frontiers in pharmacology 2021;12:751845
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C, Liu X, Yan C
Autophagy 2021 Nov;17(11):3592-3606
Autophagy 2021 Nov;17(11):3592-3606
The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice.
Lehrke MJ, Shapiro MJ, Rajcula MJ, Kennedy MM, McCue SA, Medina KL, Shapiro VS
eLife 2021 Nov 11;10
eLife 2021 Nov 11;10
Galectin-7 overexpression destroys airway epithelial barrier in transgenic mice.
Tian J, He R, Fan Y, Zhang Q, Tian B, Zhou C, Liu C, Song M, Zhao S
Integrative zoology 2021 Mar;16(2):270-279
Integrative zoology 2021 Mar;16(2):270-279
The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases.
Peng GX, Zhang Y, Wang QQ, Li QR, Xu H, Wang ED, Zhou XL
Nucleic acids research 2021 Mar 18;49(5):2816-2834
Nucleic acids research 2021 Mar 18;49(5):2816-2834
Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.
Jin X, Zhang J, Yi Q, Meng F, Yu J, Ji Y, Mo JQ, Tong Y, Jiang P, Guan MX
Investigative ophthalmology & visual science 2021 Jun 1;62(7):22
Investigative ophthalmology & visual science 2021 Jun 1;62(7):22
Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes.
Wei X, Maharjan Y, Dorotea D, Dutta RK, Kim D, Kim H, Mu Y, Park C, Park R
International journal of molecular sciences 2021 Jul 26;22(15)
International journal of molecular sciences 2021 Jul 26;22(15)
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, Wang G, Chen J, Qi X, Tao Z, Ren J
Life sciences 2021 Jul 1;276:119415
Life sciences 2021 Jul 1;276:119415
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering in vivo.
Han S, Zhao F, Hsia J, Ma X, Liu Y, Torres S, Fujioka H, Zhu X
Journal of cell science 2021 Jul 1;134(13)
Journal of cell science 2021 Jul 1;134(13)
Bioactivation of clozapine by mitochondria of the murine heart: Possible cause of cardiotoxicity.
Arzuk E, Karakuş F, Orhan H
Toxicology 2021 Jan 15;447:152628
Toxicology 2021 Jan 15;447:152628
Mtu1 defects are correlated with reduced osteogenic differentiation.
He Q, Zhao Q, Li Q, Pan R, Li X, Chen Y
Cell death & disease 2021 Jan 11;12(1):61
Cell death & disease 2021 Jan 11;12(1):61
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D-TSG101 interactions.
Wang J, Fang N, Xiong J, Du Y, Cao Y, Ji WK
Nature communications 2021 Feb 23;12(1):1252
Nature communications 2021 Feb 23;12(1):1252
Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Sarkar A, Stellrecht CM, Vangapandu HV, Ayres M, Kaipparettu BA, Park JH, Balakrishnan K, Burks JK, Pandita TK, Hittelman WN, Neelapu SS, Gandhi V
Haematologica 2021 Feb 1;106(2):495-512
Haematologica 2021 Feb 1;106(2):495-512
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Ma X, Zhang J, Wu Z, Wang X
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
An Experimentally Induced Mutation in the UBA Domain of p62 Changes the Sensitivity of Cisplatin by Up-Regulating HK2 Localisation on the Mitochondria and Increasing Mitophagy in A2780 Ovarian Cancer Cells.
Yu S, Yan X, Tian R, Xu L, Zhao Y, Sun L, Su J
International journal of molecular sciences 2021 Apr 13;22(8)
International journal of molecular sciences 2021 Apr 13;22(8)
Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy.
Gu C, Li L, Huang Y, Qian D, Liu W, Zhang C, Luo Y, Zhou Z, Kong F, Zhao X, Liu H, Gao P, Chen J, Yin G
Oxidative medicine and cellular longevity 2020;2020:3549704
Oxidative medicine and cellular longevity 2020;2020:3549704
miR-197-3p Represses the Proliferation of Prostate Cancer by Regulating the VDAC1/AKT/β-catenin Signaling Axis.
Huang Q, Ma B, Su Y, Chan K, Qu H, Huang J, Wang D, Qiu J, Liu H, Yang X, Wang Z
International journal of biological sciences 2020;16(8):1417-1426
International journal of biological sciences 2020;16(8):1417-1426
Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity.
Zhang Y, Ma Y, Xiao Y, Lu C, Xiao F
Ecotoxicology and environmental safety 2020 Oct 15;203:110928
Ecotoxicology and environmental safety 2020 Oct 15;203:110928
KMT2A regulates cervical cancer cell growth through targeting VDAC1.
Zhang C, Hua Y, Qiu H, Liu T, Long Q, Liao W, Qiu J, Wang N, Chen M, Shi D, Yan Y, Xie C, Deng W, Li T, Li Y
Aging 2020 May 21;12(10):9604-9620
Aging 2020 May 21;12(10):9604-9620
Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Li M, Shao J, Guo Z, Jin C, Wang L, Wang F, Jia Y, Zhu Z, Zhang Z, Zhang F, Zheng S, Wang X
Journal of cellular and molecular medicine 2020 Mar;24(5):3091-3107
Journal of cellular and molecular medicine 2020 Mar;24(5):3091-3107
Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy.
Zhu Y, Han XQ, Sun XJ, Yang R, Ma WQ, Liu NF
Apoptosis : an international journal on programmed cell death 2020 Jun;25(5-6):321-340
Apoptosis : an international journal on programmed cell death 2020 Jun;25(5-6):321-340
Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues.
Ng R, Sewanan LR, Brill AL, Stankey P, Li X, Qyang Y, Ehrlich BE, Campbell SG
American journal of physiology. Heart and circulatory physiology 2020 Jun 1;318(6):H1516-H1524
American journal of physiology. Heart and circulatory physiology 2020 Jun 1;318(6):H1516-H1524
Increased Mitochondrial Fragmentation Mediated by Dynamin-Related Protein 1 Contributes to Hexavalent Chromium-Induced Mitochondrial Respiratory Chain Complex I-Dependent Cytotoxicity.
Ma Y, Zhang Y, Xiao Y, Xiao F
Toxics 2020 Jul 29;8(3)
Toxics 2020 Jul 29;8(3)
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983
Carcinogenesis 2020 Jul 14;41(7):972-983
MiR-183-5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1.
Lin D, Cui B, Ma J, Ren J
BioFactors (Oxford, England) 2020 Jan;46(1):83-93
BioFactors (Oxford, England) 2020 Jan;46(1):83-93
Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea.
Xia B, Yu J, He T, Liu X, Su J, Wang M, Wang J, Zhu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2821-2839
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2821-2839
The protective effort of GPCR kinase 2-interacting protein-1 in neurons via promoting Beclin1-Parkin induced mitophagy at the early stage of spinal cord ischemia-reperfusion injury.
Huang YF, Gu CJ, Wang Q, Xu L, Chen J, Zhou W, Zhou Z, Zhao SJ, Li LW, Kong FQ, Qian DF, Zhao X, Fan J, Li QQ, Yin GY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2055-2074
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Feb;34(2):2055-2074
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.
Weindel CG, Bell SL, Vail KJ, West KO, Patrick KL, Watson RO
eLife 2020 Feb 14;9
eLife 2020 Feb 14;9
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Aras S, Purandare N, Gladyck S, Somayajulu-Nitu M, Zhang K, Wallace DC, Grossman LI
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Clusterin alleviates Cr(VI)-induced mitochondrial apoptosis in L02 hepatocytes via inhibition of Ca(2+)-ROS-Drp1-mitochondrial fission axis.
Tang S, Ye S, Ma Y, Liang Y, Liang N, Xiao F
Ecotoxicology and environmental safety 2020 Dec 1;205:111326
Ecotoxicology and environmental safety 2020 Dec 1;205:111326
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.
Ren KD, Liu WN, Tian J, Zhang YY, Peng JJ, Zhang D, Li NS, Yang J, Peng J, Luo XJ
European journal of pharmacology 2019 Oct 15;861:172617
European journal of pharmacology 2019 Oct 15;861:172617
Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells.
Tan Y, Jin Y, Wang Q, Huang J, Wu X, Ren Z
Cells 2019 Oct 11;8(10)
Cells 2019 Oct 11;8(10)
DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.
Yang M, Zhao L, Gao P, Zhu X, Han Y, Chen X, Li L, Xiao Y, Wei L, Li C, Xiao L, Yuan S, Liu F, Dong LQ, Kanwar YS, Sun L
EBioMedicine 2019 May;43:607-619
EBioMedicine 2019 May;43:607-619
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
Exenatide Reduces Graft Injury in a Rat Transplantation Model Using Kidneys Donated after Cardiac Death.
Hua Yang, Shi Y, Long C, Li X, Luo L, Chen M, Li H, Wang Z
Transplantation proceedings 2019 Jul-Aug;51(6):2116-2123
Transplantation proceedings 2019 Jul-Aug;51(6):2116-2123
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.
Liu Y, Ma X, Fujioka H, Liu J, Chen S, Zhu X
Proceedings of the National Academy of Sciences of the United States of America 2019 Dec 10;116(50):25322-25328
Proceedings of the National Academy of Sciences of the United States of America 2019 Dec 10;116(50):25322-25328
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, Lu F, Liu N, Yu M, Peng S, Wang Y, Zhao D, Zhao Y, Ren H, Cheng Z, Dong S, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
A novel ent-kaurane diterpenoid analog, DN3, selectively kills human gastric cancer cells via acting directly on mitochondria.
Ma YC, Zhu YL, Su N, Ke Y, Fan XX, Shi XJ, Liu HM, Wang AF
European journal of pharmacology 2019 Apr 5;848:11-22
European journal of pharmacology 2019 Apr 5;848:11-22
Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.
Iida R, Ueki M, Yasuda T
Oxidative medicine and cellular longevity 2018;2018:6956414
Oxidative medicine and cellular longevity 2018;2018:6956414
Abnormal CYP11A1 gene expression induces excessive autophagy, contributing to the pathogenesis of preeclampsia.
Pan T, He G, Chen M, Bao C, Chen Y, Liu G, Zhou M, Li S, Xu W, Liu X
Oncotarget 2017 Oct 27;8(52):89824-89836
Oncotarget 2017 Oct 27;8(52):89824-89836
Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress.
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British journal of pharmacology 2017 Dec;174(23):4409-4429
British journal of pharmacology 2017 Dec;174(23):4409-4429
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, Zhang L, Dong S, Yang F, Zhong X, Xu C, Lu F, Zhang W
Cell death & disease 2017 Aug 10;8(8):e2992
Cell death & disease 2017 Aug 10;8(8):e2992
Neonatal mitochondrial hepatoencephalopathy caused by novel GFM1 mutations.
Ravn K, Schönewolf-Greulich B, Hansen RM, Bohr AH, Duno M, Wibrand F, Ostergaard E
Molecular genetics and metabolism reports 2015 Jun;3:5-10
Molecular genetics and metabolism reports 2015 Jun;3:5-10
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 55259-1-AP(VDAC1 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 55259-1-AP(VDAC1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 55259-1-AP(VDAC1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The VDAC1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human VDAC1. This antibody recognizes human,mouse,rat antigen. The VDAC1 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
