Antibody data
- Antibody Data
- Antigen structure
- References [88]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 55184-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- WNT5A/B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated WNT5A/B antibody (Cat. #55184-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dendrobine ameliorates non-alcoholic fatty liver disease by inhibiting mitochondrial fission through modulation of the Wnt5a/p-CaMKII/p-Drp1 signaling axis.
Giant cell tumor of bone inhibits osteoblastogenesis via WNT5B.
Targeted AAV6 gene therapy restores corneal endothelial function in three hereditary corneal dystrophies.
Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.
Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis.
FRZB regulates the osteogenic differentiation of periodontal ligament stem cells in an inflammatory microenvironment through Wnt5a-mitochondrial axis.
CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway.
Eucommia ulmoides extract attenuates oxidative stress and promotes melanogenesis via Wnt/β-catenin signaling in B16 cells and mice.
Immune-related hub genes in intrauterine adhesions: a bioinformatics approach.
Shenling Tongqiao powder targets TGF-β1/Smad-Wnt/β-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis.
Tunneling nanotube-mediated stem cell immunomodulation dysfunction promotes adipose inflammation and insulin resistance in GDM.
Cranial repair-promoting effect of oxidised sodium alginate/amino gelatine injectable hydrogel loaded with deer antler blood peptides.
Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer.
Caffeic Acid Phenethyl Ester Enhances Bone Repair-related Factors in MC3T3-E1 Cells.
PPAR-gamma agonist pioglitazone improves endometrial receptivity, reverses endometrial barrier disruption and promotes ovarian function in thin endometrium rats via modulation PPAR-γ/Wnt5/β-catenin pathway.
MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis.
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling.
Astrocytes-Secreted WNT5B Disrupts the Blood-Brain Barrier Via ROR1/JNK/c-JUN Cascade During Meningitic Escherichia Coli Infection.
MAFB-mediated CEBPA regulated human urothelium growth through Wnt/β-catenin signaling pathway.
Wnt5a negatively regulates melanogenesis in primary Arctic fox epidermal melanocytes.
Biomimetic Topological Micropattern Arrays Regulate the Heterogeneity of Cellular Fates in Lung Fibroblasts between Fibrosis and Invasion.
Cyclin G1 Regulates the Alveolarization in Models of Bronchopulmonary Dysplasia by Inhibiting AT2 Cell Proliferation.
Using chondroitin sulfate lithium hydrogel for diabetic bone regeneration via regulation of macrophage polarization.
Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease.
NCAPD2 stimulates glycolysis and esophageal cancer metastasis through Wnt5A-dependent Notch activation.
MFAP5 Activates ITGA5 to Drive Tooth Germ Mineralization Through the MAPK/ERK Pathway: Insights from Single-Cell Transcriptomics.
Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryo.
Quercetin improves airway remodeling in COPD rats by suppressing phenotypic switch of ASMCs via inhibiting the Wnt5a/β-catenin pathway.
The Roxadustat (FG-4592) ameliorates tubulointerstitial fibrosis by promoting intact FGF23 cleavage.
KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer.
PCSK9 inhibitor alleviates experimental pulmonary fibrosis-induced pulmonary hypertension via attenuating epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling in vivo and in vitro.
The sensory nerve regulates stem cell homeostasis through Wnt5a signaling.
Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility.
KAT2A-mediated succinylation modification of notch1 promotes the proliferation and differentiation of dental pulp stem cells by activating notch pathway.
A novel microglia-targeting strategy based on nanoparticle-mediated delivery of miR-26a-5p for long-lasting analgesia in chronic pain.
Upregulated miR-374a-5p drives psoriasis pathogenesis through WIF1 downregulation and Wnt5a/NF-κB activation.
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Cytoneme-mediated transport of active Wnt5b-Ror2 complexes in zebrafish.
Gynostemma pentaphyllum Makino extract induces hair growth and exhibits an anti-graying effect via multiple mechanisms.
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer.
Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration.
TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.
Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds.
Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2.
Retinoic acid delays murine palatal shelf elevation by inhibiting Wnt5a-mediated noncanonical Wnt signaling and downstream Cdc-42/F-actin remodeling in mesenchymal cells.
Hepatotoxicity evaluation and possible mechanisms of decabrominated diphenyl ethers (BDE-209) in broilers: Oxidative stress, inflammatory, and transcriptomics.
CircTNPO1 promotes the tumorigenesis of osteosarcoma by sequestering miR-578 to upregulate WNT5A expression.
miR-26a-5p alleviates CFA-induced chronic inflammatory hyperalgesia through Wnt5a/CaMKII/NFAT signaling in mice.
Implications of CRNDE in prognosis, tumor immunity, and therapeutic sensitivity in low grade glioma patients.
Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.
Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling.
RNA-binding Protein QKI Inhibits Osteogenic Differentiation Via Suppressing Wnt Pathway.
Ergothioneine improves myocardial remodeling and heart function after acute myocardial infarction via S-glutathionylation through the NF-ĸB dependent Wnt5a-sFlt-1 pathway.
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression.
The Hair Growth-Promoting Effect of Gardenia florida Fruit Extract and Its Molecular Regulation.
RETRACTED: Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption.
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model.
An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.
SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer.
WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
Ginsenoside Rh4 Suppresses Metastasis of Esophageal Cancer and Expression of c-Myc via Targeting the Wnt/β-Catenin Signaling Pathway.
Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) decoction suppresses colorectal cancer via downregulation of Wnt5/β-Catenin signal.
Interferon-dependent SLC14A1(+) cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer.
Substrate stiffness regulates differentiation of induced pluripotent stem cells into heart valve endothelial cells.
Macrophage-Mediated Bone Formation in Scaffolds Modified With MSC-Derived Extracellular Matrix Is Dependent on the Migration Inhibitory Factor Signaling Pathway.
Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway.
MicroRNA‑8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self‑renewal of colorectal cancer stem cells via the Wnt/β‑catenin pathway.
The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma.
miR-374 improves cerebral ischemia reperfusion injury by targeting Wnt5a.
Exercise Promotes the Osteoinduction of HA/β-TCP Biomaterials via the Wnt Signaling Pathway.
Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose-derived stem cells through the hsa-miR-129-5p/GRM5 axis via the Wnt signaling pathway.
Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway.
CircRNA circ-0038718 promotes hepatocellular carcinoma progression through sponging miR-139-3p.
Wnt5a is involved in LOX-1 and TLR4 induced host inflammatory response in peri-implantitis.
Perfluorooctanoic acid-induced toxicities in chicken embryo primary cardiomyocytes: Roles of PPAR alpha and Wnt5a/Frizzled2.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Coupling of apical-basal polarity and planar cell polarity to interpret the Wnt signaling gradient in feather development.
Osteogenesis potential of different titania nanotubes in oxidative stress microenvironment.
Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis.
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.
Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation.
Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation.
Fu X, Gou S, Shi L, Tan L, Xian Y, Fan N, Hu L, Liao S, Huang J, Wu Q, Zhou S
Journal of ethnopharmacology 2026 May 23;363:121445
Journal of ethnopharmacology 2026 May 23;363:121445
Giant cell tumor of bone inhibits osteoblastogenesis via WNT5B.
Shimada M, Tsuyama T, Yoshimura N, Tateyama M, Matsunaga H, Homma F, Dainobu K, Tian X, Takata S, Takata K, Tanimura S, Shibata Y, Maeda K, Kawakami J, Arima T, Karasugi T, Tokunaga T, Sato H, Masuda T, Hisanaga S, Kai Y, Karata S, Goshogawa H, Tajiri R, Yamada H, Uehara Y, Nakamura T, Yugami M, Sugimoto K, Yonemitsu R, Tanoue H, Yamagata K, Miyamoto T
Journal of bone and mineral metabolism 2026 Mar 23;
Journal of bone and mineral metabolism 2026 Mar 23;
Targeted AAV6 gene therapy restores corneal endothelial function in three hereditary corneal dystrophies.
Zhang BN, Qi B, Chen S, Su J, Li G, Wang X, Ren Z, Zhang H, Cheng J, Qu J, Yang Y, Zhou Q, Cong L, Xie L
Cell reports. Medicine 2026 Mar 17;7(3):102649
Cell reports. Medicine 2026 Mar 17;7(3):102649
Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.
Chen X, Chen X, Xie J, Guo D
Molecular biotechnology 2026 Feb;68(2):496-506
Molecular biotechnology 2026 Feb;68(2):496-506
Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis.
Wu A, Wang Y, Liu F, Cao Z, Du S, Sun M
Molecular medicine reports 2026 Feb;33(2)
Molecular medicine reports 2026 Feb;33(2)
FRZB regulates the osteogenic differentiation of periodontal ligament stem cells in an inflammatory microenvironment through Wnt5a-mitochondrial axis.
Su Y, Wang H, Luo T, Liu J, Hu X
Cell regeneration (London, England) 2026 Feb 6;15(1):9
Cell regeneration (London, England) 2026 Feb 6;15(1):9
CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway.
Tao C, Li S, Sun D, Zhou J, Chen Y, Zhang R, Ni X
Journal of cellular and molecular medicine 2026 Apr;30(7):e71124
Journal of cellular and molecular medicine 2026 Apr;30(7):e71124
Eucommia ulmoides extract attenuates oxidative stress and promotes melanogenesis via Wnt/β-catenin signaling in B16 cells and mice.
Liu X, Qiu Y, Lv X, Chang L, Ji T, Gu Y, Chen S
Turkish journal of biology = Turk biyoloji dergisi 2025;49(7):790-799
Turkish journal of biology = Turk biyoloji dergisi 2025;49(7):790-799
Immune-related hub genes in intrauterine adhesions: a bioinformatics approach.
Lv F, Luo S, Xu F, Du Y, Bai Y, Zhang J, Zou X, Liu D
PeerJ 2025;13:e20035
PeerJ 2025;13:e20035
Shenling Tongqiao powder targets TGF-β1/Smad-Wnt/β-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis.
Liu K, Zeng H, Zhu X, Deng H, Deng W, Li S, Zhu Y, Bin J, Lu S, Wu W, Wu Q, Liao J, Hu G, Chang W, Ying Y, Wang Y, Zhu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157065
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157065
Tunneling nanotube-mediated stem cell immunomodulation dysfunction promotes adipose inflammation and insulin resistance in GDM.
Chen B, Chen X, Li J, Hu R, Yang L, Li H, Liu X, Cannon RD, Saffery R, Novakovic B, Qi H, Zhang H, Zhou X
Cell reports 2025 Nov 25;44(11):116505
Cell reports 2025 Nov 25;44(11):116505
Cranial repair-promoting effect of oxidised sodium alginate/amino gelatine injectable hydrogel loaded with deer antler blood peptides.
Yu T, Ding Q, Wang N, Zhang S, Cheng Z, Zhao C, Li Q, Ding C, Liu W
International journal of biological macromolecules 2025 May;305(Pt 1):141116
International journal of biological macromolecules 2025 May;305(Pt 1):141116
Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer.
Lu Y, Chen Y, Wang Z, Shen H, Xu L, Huang C, Tong Y, Shao Y, Zhang H, Fu Z
Journal of translational medicine 2025 Mar 6;23(1):282
Journal of translational medicine 2025 Mar 6;23(1):282
Caffeic Acid Phenethyl Ester Enhances Bone Repair-related Factors in MC3T3-E1 Cells.
Kuramoto H, Nakanishi T, Yumoto H, Takegawa D, Mieda K, Hosaka K
Cell biochemistry and biophysics 2025 Jun;83(2):2323-2331
Cell biochemistry and biophysics 2025 Jun;83(2):2323-2331
PPAR-gamma agonist pioglitazone improves endometrial receptivity, reverses endometrial barrier disruption and promotes ovarian function in thin endometrium rats via modulation PPAR-γ/Wnt5/β-catenin pathway.
Li H, Guan Y, Chen X, Tian W, Xie J, Yang B
Journal of reproductive immunology 2025 Jun;169:104526
Journal of reproductive immunology 2025 Jun;169:104526
MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis.
Zhang L, Zhou B, Yang J, Ren C, Luo J, Li Z, Liu Q, Huang Z, Wu Z, Jiang N
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2416419
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2416419
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling.
Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhang M, Zhou J, Wang F
Scientific reports 2025 Jul 10;15(1):24968
Scientific reports 2025 Jul 10;15(1):24968
Astrocytes-Secreted WNT5B Disrupts the Blood-Brain Barrier Via ROR1/JNK/c-JUN Cascade During Meningitic Escherichia Coli Infection.
Qu X, Yang R, Tan C, Chen H, Wang X
Molecular neurobiology 2025 Jan;62(1):661-673
Molecular neurobiology 2025 Jan;62(1):661-673
MAFB-mediated CEBPA regulated human urothelium growth through Wnt/β-catenin signaling pathway.
Liu Z, Luo X, Zhang Z, Zhang Q, Wang C, Chen H, Long C, Liu X, Wei G
Genes & diseases 2025 Jan;12(1):101432
Genes & diseases 2025 Jan;12(1):101432
Wnt5a negatively regulates melanogenesis in primary Arctic fox epidermal melanocytes.
Hong Z, Wang D, Qiao X, Xie Y, Yang S, Hao K, Han C, Liu H, Liu Z
Gene 2025 Jan 20;934:149045
Gene 2025 Jan 20;934:149045
Biomimetic Topological Micropattern Arrays Regulate the Heterogeneity of Cellular Fates in Lung Fibroblasts between Fibrosis and Invasion.
Zhu X, Mao S, Yang Y, Liu X, Liu Q, Zhang N, Yang Y, Li Y, Gao M, Bao J, Li W, Li Y
ACS nano 2025 Jan 14;19(1):580-599
ACS nano 2025 Jan 14;19(1):580-599
Cyclin G1 Regulates the Alveolarization in Models of Bronchopulmonary Dysplasia by Inhibiting AT2 Cell Proliferation.
Xu P, Zhuo W, Zhang P, Chen Y, Du Y, Li Y, Wang Y
Biomolecules 2025 Jan 10;15(1)
Biomolecules 2025 Jan 10;15(1)
Using chondroitin sulfate lithium hydrogel for diabetic bone regeneration via regulation of macrophage polarization.
Xu C, Li W, Mao J, Liu Z, Lao A, Mao L, Gu A, Wu J, Shen A, Lin K, Liu J
Carbohydrate polymers 2025 Jan 1;347:122787
Carbohydrate polymers 2025 Jan 1;347:122787
Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease.
Fang K, Pishva E, Piers T, Scholpp S
Journal of cell science 2025 Feb 1;138(3)
Journal of cell science 2025 Feb 1;138(3)
NCAPD2 stimulates glycolysis and esophageal cancer metastasis through Wnt5A-dependent Notch activation.
Xu Q, Yang S
Cellular signalling 2025 Dec;136:112120
Cellular signalling 2025 Dec;136:112120
MFAP5 Activates ITGA5 to Drive Tooth Germ Mineralization Through the MAPK/ERK Pathway: Insights from Single-Cell Transcriptomics.
Wang X, Gu L, Zhang P, Zhou Y
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryo.
Isaac S, Dubosky D, Waldron A, Emura N, Furze A, Rao K, Mori M, Ragavendran A, Makinoshima H, Yajima M
Nature communications 2025 Aug 11;16(1):7410
Nature communications 2025 Aug 11;16(1):7410
Quercetin improves airway remodeling in COPD rats by suppressing phenotypic switch of ASMCs via inhibiting the Wnt5a/β-catenin pathway.
Zhou H, Lai Y, Zhu Y, Shao F, Ma G, Yang N, Ma X, Sun Y, Shi Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156491
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156491
The Roxadustat (FG-4592) ameliorates tubulointerstitial fibrosis by promoting intact FGF23 cleavage.
Wang J, Li ZL, Zhou Y, Li ZT, Tu Y, Hu XH, Zhu JH, Liu BC, Liu H
Cell communication and signaling : CCS 2025 Apr 25;23(1):200
Cell communication and signaling : CCS 2025 Apr 25;23(1):200
KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer.
Cong S, Fu Y, Zhao X, Guo Q, Liang T, Wu D, Wang J, Zhang G
Journal of immunology research 2024;2024:4817924
Journal of immunology research 2024;2024:4817924
PCSK9 inhibitor alleviates experimental pulmonary fibrosis-induced pulmonary hypertension via attenuating epithelial-mesenchymal transition by suppressing Wnt/β-catenin signaling in vivo and in vitro.
Lin J, Pan Z, Sun J, Wang X, Yin D, Huo C, Guo Q
Frontiers in medicine 2024;11:1509168
Frontiers in medicine 2024;11:1509168
The sensory nerve regulates stem cell homeostasis through Wnt5a signaling.
Zhang T, Liu J, Jin W, Nie H, Chen S, Tang X, Liu R, Wang M, Chen R, Lu J, Bao J, Jiang S, Xiao Y, Yan F
iScience 2024 Oct 18;27(10):111035
iScience 2024 Oct 18;27(10):111035
Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility.
Wang FC, Zhang XN, Wu SX, He Z, Zhang LY, Yang QE
Cellular and molecular life sciences : CMLS 2024 May 9;81(1):212
Cellular and molecular life sciences : CMLS 2024 May 9;81(1):212
KAT2A-mediated succinylation modification of notch1 promotes the proliferation and differentiation of dental pulp stem cells by activating notch pathway.
Ye L, Yu Z, He L, Yuan J, Zhang X, Li L, Huang X, Ma Y, Zhang L
BMC oral health 2024 Mar 31;24(1):407
BMC oral health 2024 Mar 31;24(1):407
A novel microglia-targeting strategy based on nanoparticle-mediated delivery of miR-26a-5p for long-lasting analgesia in chronic pain.
Lu Y, Liu S, Wang P, Guo X, Qin Z, Hou H, Tao T
Journal of nanobiotechnology 2024 Mar 23;22(1):128
Journal of nanobiotechnology 2024 Mar 23;22(1):128
Upregulated miR-374a-5p drives psoriasis pathogenesis through WIF1 downregulation and Wnt5a/NF-κB activation.
Ma J, Gan L, Chen H, Chen L, Hu Y, Luan C, Chen K, Zhang J
Cellular signalling 2024 Jul;119:111171
Cellular signalling 2024 Jul;119:111171
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Zhang Z, Hu J
Journal of translational medicine 2024 Jul 3;22(1):617
Journal of translational medicine 2024 Jul 3;22(1):617
Cytoneme-mediated transport of active Wnt5b-Ror2 complexes in zebrafish.
Zhang C, Brunt L, Ono Y, Rogers S, Scholpp S
Nature 2024 Jan;625(7993):126-133
Nature 2024 Jan;625(7993):126-133
Gynostemma pentaphyllum Makino extract induces hair growth and exhibits an anti-graying effect via multiple mechanisms.
Liu X, Lv X, Ji T, Hu H, Chang L
Journal of cosmetic dermatology 2024 Feb;23(2):648-657
Journal of cosmetic dermatology 2024 Feb;23(2):648-657
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Xue Q, Li J, Qin R, Li M, Li Y, Zhang J, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2024 Aug;23(8):e14202
Aging cell 2024 Aug;23(8):e14202
Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer.
Huang Z, Meng FY, Lu LZ, Guo QQ, Lv CJ, Tan NH, Deng Z, Chen JY, Zhang ZS, Zou B, Long HP, Zhou Q, Tian S, Mei S, Tian XF
World journal of gastroenterology 2024 Aug 7;30(29):3511-3533
World journal of gastroenterology 2024 Aug 7;30(29):3511-3533
Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration.
Liu H, Zheng Y, Kan S, Hao M, Jiang H, Li S, Li R, Wang Y, Wang D, Liu W
Heliyon 2024 Apr 30;10(8):e29291
Heliyon 2024 Apr 30;10(8):e29291
TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.
Li Y, Luan S, Ruan C, Li W, Zhang X, Ran Z, Bi W, Tong Y, Gao L, Zhao J, Li Y, He Z
Biochemical and biophysical research communications 2024 Apr 16;704:149723
Biochemical and biophysical research communications 2024 Apr 16;704:149723
Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds.
Chen Y, Qian H, Peng D, Jiang Y, Liu Q, Tan Y, Feng L, Cheng B, Li G
Frontiers in bioengineering and biotechnology 2023;11:1338172
Frontiers in bioengineering and biotechnology 2023;11:1338172
Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2.
Rogers S, Zhang C, Anagnostidis V, Liddle C, Fishel ML, Gielen F, Scholpp S
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 26;120(39):e2217612120
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 26;120(39):e2217612120
Retinoic acid delays murine palatal shelf elevation by inhibiting Wnt5a-mediated noncanonical Wnt signaling and downstream Cdc-42/F-actin remodeling in mesenchymal cells.
Ma YQ, Zhang XY, Zhao SW, Li D, Cai MQ, Yang H, Wang XM, Xue H
Birth defects research 2023 Oct 15;115(17):1658-1673
Birth defects research 2023 Oct 15;115(17):1658-1673
Hepatotoxicity evaluation and possible mechanisms of decabrominated diphenyl ethers (BDE-209) in broilers: Oxidative stress, inflammatory, and transcriptomics.
Yang Y, Jin Y, Zhu X, Rao Q, Zhao Z, Yang J
Ecotoxicology and environmental safety 2023 Oct 1;264:115460
Ecotoxicology and environmental safety 2023 Oct 1;264:115460
CircTNPO1 promotes the tumorigenesis of osteosarcoma by sequestering miR-578 to upregulate WNT5A expression.
Shi Y, Tian Y, Wu Y, Zhao Y
Cellular signalling 2023 Nov;111:110858
Cellular signalling 2023 Nov;111:110858
miR-26a-5p alleviates CFA-induced chronic inflammatory hyperalgesia through Wnt5a/CaMKII/NFAT signaling in mice.
Lu Y, Liu M, Guo X, Wang P, Zeng F, Wang H, Tang J, Qin Z, Tao T
CNS neuroscience & therapeutics 2023 May;29(5):1254-1271
CNS neuroscience & therapeutics 2023 May;29(5):1254-1271
Implications of CRNDE in prognosis, tumor immunity, and therapeutic sensitivity in low grade glioma patients.
Yang C, Jiang Y, Hu F, Li Q, Qi B
Cancer cell international 2023 May 16;23(1):93
Cancer cell international 2023 May 16;23(1):93
Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.
Wu Y, Terekhanova NV, Caravan W, Naser Al Deen N, Lal P, Chen S, Mo CK, Cao S, Li Y, Karpova A, Liu R, Zhao Y, Shinkle A, Strunilin I, Weimholt C, Sato K, Yao L, Serasanambati M, Yang X, Wyczalkowski M, Zhu H, Zhou DC, Jayasinghe RG, Mendez D, Wendl MC, Clark D, Newton C, Ruan Y, Reimers MA, Pachynski RK, Kinsinger C, Jewell S, Chan DW, Zhang H, Chaudhuri AA, Chheda MG, Humphreys BD, Mesri M, Rodriguez H, Hsieh JJ, Ding L, Chen F
Nature communications 2023 Mar 27;14(1):1681
Nature communications 2023 Mar 27;14(1):1681
Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.
Rickman M, Ghim M, Pang K, von Huelsen Rocha AC, Drudi EM, Sureda-Vives M, Ayoub N, Tajadura-Ortega V, George SJ, Weinberg PD, Warboys CM
Journal of cell science 2023 Mar 15;136(6)
Journal of cell science 2023 Mar 15;136(6)
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling.
Wu H, Tang LX, Wang XM, Li LP, Chen XK, He YJ, Yang DZ, Shi Y, Shou JL, Zhang ZS, Wang L, Lu BJ, An SM, Zeng CY, Wang WE
Acta pharmacologica Sinica 2023 Jun;44(6):1149-1160
Acta pharmacologica Sinica 2023 Jun;44(6):1149-1160
RNA-binding Protein QKI Inhibits Osteogenic Differentiation Via Suppressing Wnt Pathway.
Yan Z, Ruan B, Wang S, Du T, Shao X, Chen G, Wang L, Zhai D, Zhu S, Lu Z, Cao X
Archives of medical research 2023 Jul;54(5):102853
Archives of medical research 2023 Jul;54(5):102853
Ergothioneine improves myocardial remodeling and heart function after acute myocardial infarction via S-glutathionylation through the NF-ĸB dependent Wnt5a-sFlt-1 pathway.
Duan R, Pan H, Li D, Liao S, Han B
European journal of pharmacology 2023 Jul 5;950:175759
European journal of pharmacology 2023 Jul 5;950:175759
Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression.
Zhang H, Wang L, Cui J, Wang S, Han Y, Shao H, Wang C, Hu Y, Li X, Zhou Q, Guo J, Zhuang X, Sheng S, Zhang T, Zhou D, Chen J, Wang F, Gao Q, Jing Y, Chen X, Su J
Science advances 2023 Apr 5;9(14):eabo7868
Science advances 2023 Apr 5;9(14):eabo7868
The Hair Growth-Promoting Effect of Gardenia florida Fruit Extract and Its Molecular Regulation.
Liu X, Ji T, Hu H, Lv X, Zhu G
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8498974
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8498974
RETRACTED: Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption.
Ding D, Wang L, Yan J, Zhou Y, Feng G, Ma L, Yang Y, Pei X, Jin Q
PloS one 2022;17(7):e0271485
PloS one 2022;17(7):e0271485
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Zhou Z, Wei B, Liu Y, Liu T, Zeng S, Gan J, Qi G
Frontiers in genetics 2022;13:1035638
Frontiers in genetics 2022;13:1035638
Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model.
Lu Y, Zhang J, Zeng F, Wang P, Guo X, Wang H, Qin Z, Tao T
Journal of neuroinflammation 2022 Sep 7;19(1):221
Journal of neuroinflammation 2022 Sep 7;19(1):221
An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.
Wang D, Tian Y, Zhang Y, Sun X, Wu Y, Liu R, Zeng F, Du J, Hu K
Nanoscale 2022 Oct 27;14(41):15384-15392
Nanoscale 2022 Oct 27;14(41):15384-15392
SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer.
Bhattacharya A, Wei J, Song W, Gao B, Tian C, Wu SA, Wang J, Chen L, Fang D, Qi L
iScience 2022 Oct 21;25(10):105183
iScience 2022 Oct 21;25(10):105183
WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
Feng Y, Ma Z, Pan M, Xu L, Feng J, Zhang Y, Shao C, Guo K, Duan H, Zhang Y, Zhang Y, Zhang J, Lu D, Ren X, Han J, Li X, Yan X
Cell death & disease 2022 May 20;13(5):480
Cell death & disease 2022 May 20;13(5):480
Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.
Lin T, Tao J, Chen Y, Zhang Y, Li F, Zhang Y, Han X, Zhao Z, Liu G, Li H
Biological trace element research 2022 Mar;200(3):1127-1139
Biological trace element research 2022 Mar;200(3):1127-1139
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
Zhou D, Wang Y, Gui Y, Fu H, Zhou S, Wang Y, Bastacky SI, Stolz DB, Liu Y
Kidney international 2022 Jul;102(1):96-107
Kidney international 2022 Jul;102(1):96-107
Ginsenoside Rh4 Suppresses Metastasis of Esophageal Cancer and Expression of c-Myc via Targeting the Wnt/β-Catenin Signaling Pathway.
Chen J, Duan Z, Liu Y, Fu R, Zhu C
Nutrients 2022 Jul 25;14(15)
Nutrients 2022 Jul 25;14(15)
Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) decoction suppresses colorectal cancer via downregulation of Wnt5/β-Catenin signal.
Bian Y, Wang G, Zhou J, Yin G, Liu T, Liang L, Yang X, Zhang W, Ni K, Tang D, Yu Y
Chinese medicine 2022 Jan 6;17(1):11
Chinese medicine 2022 Jan 6;17(1):11
Interferon-dependent SLC14A1(+) cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer.
Ma Z, Li X, Mao Y, Wei C, Huang Z, Li G, Yin J, Liang X, Liu Z
Cancer cell 2022 Dec 12;40(12):1550-1565.e7
Cancer cell 2022 Dec 12;40(12):1550-1565.e7
Substrate stiffness regulates differentiation of induced pluripotent stem cells into heart valve endothelial cells.
Cao H, Zhou Q, Liu C, Zhang Y, Xie M, Qiao W, Dong N
Acta biomaterialia 2022 Apr 15;143:115-126
Acta biomaterialia 2022 Apr 15;143:115-126
Macrophage-Mediated Bone Formation in Scaffolds Modified With MSC-Derived Extracellular Matrix Is Dependent on the Migration Inhibitory Factor Signaling Pathway.
Deng M, Tan J, Dai Q, Luo F, Xu J
Frontiers in cell and developmental biology 2021;9:714011
Frontiers in cell and developmental biology 2021;9:714011
Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway.
Guo H, Ding D, Wang L, Yan J, Ma L, Jin Q
PloS one 2021;16(12):e0261127
PloS one 2021;16(12):e0261127
MicroRNA‑8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self‑renewal of colorectal cancer stem cells via the Wnt/β‑catenin pathway.
Chen ZQ, Yuan T, Jiang H, Yang YY, Wang L, Fu RM, Luo SQ, Zhang T, Wu ZY, Wen KM
Oncology reports 2021 Oct;46(4)
Oncology reports 2021 Oct;46(4)
The m(6) A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
Yu J, She Y, Yang L, Zhuang M, Han P, Liu J, Lin X, Wang N, Chen M, Jiang C, Zhang Y, Yuan Y, Ji SJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101329
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101329
Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma.
Yang J, Lin P, Yang M, Liu W, Fu X, Liu D, Tao L, Huo Y, Zhang J, Hua R, Zhang Z, Li Y, Wang L, Xue J, Li H, Sun Y
Genome biology 2021 Jan 4;22(1):4
Genome biology 2021 Jan 4;22(1):4
miR-374 improves cerebral ischemia reperfusion injury by targeting Wnt5a.
Xing F, Liu Y, Dong R, Cheng Y
Experimental animals 2021 Feb 6;70(1):126-136
Experimental animals 2021 Feb 6;70(1):126-136
Exercise Promotes the Osteoinduction of HA/β-TCP Biomaterials via the Wnt Signaling Pathway.
Cheng L, Khalaf AT, Lin T, Ran L, Shi Z, Wan J, Zhou X, Zou L
Metabolites 2020 Mar 5;10(3)
Metabolites 2020 Mar 5;10(3)
Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose-derived stem cells through the hsa-miR-129-5p/GRM5 axis via the Wnt signaling pathway.
Shi ZL, Zhang H, Fan ZY, Ma W, Song YZ, Li M, Li TQ, Cao SX, Feng GJ
Stem cell research & therapy 2020 Jun 17;11(1):240
Stem cell research & therapy 2020 Jun 17;11(1):240
Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway.
Yu T, Dong D, Guan J, Sun J, Guo M, Wang Q
Herz 2020 Dec;45(Suppl 1):130-138
Herz 2020 Dec;45(Suppl 1):130-138
CircRNA circ-0038718 promotes hepatocellular carcinoma progression through sponging miR-139-3p.
Sun R, Li H, Li J, Shen S, Cui G, Dong G
Biochemical and biophysical research communications 2020 Dec 17;533(4):845-852
Biochemical and biophysical research communications 2020 Dec 17;533(4):845-852
Wnt5a is involved in LOX-1 and TLR4 induced host inflammatory response in peri-implantitis.
Zhang Q, Liu J, Ma L, Bai N, Xu H
Journal of periodontal research 2020 Apr;55(2):199-208
Journal of periodontal research 2020 Apr;55(2):199-208
Perfluorooctanoic acid-induced toxicities in chicken embryo primary cardiomyocytes: Roles of PPAR alpha and Wnt5a/Frizzled2.
Lv N, Yuan J, Ji A, Shi L, Gao M, Cui L, Jiang Q
Toxicology and applied pharmacology 2019 Oct 15;381:114716
Toxicology and applied pharmacology 2019 Oct 15;381:114716
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Coupling of apical-basal polarity and planar cell polarity to interpret the Wnt signaling gradient in feather development.
Lin J, Yue Z
Development (Cambridge, England) 2018 Sep 14;145(17)
Development (Cambridge, England) 2018 Sep 14;145(17)
Osteogenesis potential of different titania nanotubes in oxidative stress microenvironment.
Yu Y, Shen X, Luo Z, Hu Y, Li M, Ma P, Ran Q, Dai L, He Y, Cai K
Biomaterials 2018 Jun;167:44-57
Biomaterials 2018 Jun;167:44-57
Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis.
Che C, Li C, Lin J, Zhang J, Jiang N, Yuan K, Zhao G
Cellular signalling 2018 Dec;52:103-111
Cellular signalling 2018 Dec;52:103-111
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.
Xing F, Yi WJ, Miao F, Su MY, Lei TC
International journal of molecular medicine 2018 Apr;41(4):2079-2085
International journal of molecular medicine 2018 Apr;41(4):2079-2085
Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation.
Ma J, Huang C, Ma K, Wu YP, Li BX, Sun Y
Molecular medicine reports 2017 Dec;16(6):9721-9728
Molecular medicine reports 2017 Dec;16(6):9721-9728
Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation.
Hu Z, Zhang Y, Li Z, Yu Y, Kang W, Han Y, Geng X, Ge S, Sun Y
Oncotarget 2016 Oct 11;7(41):66700-66712
Oncotarget 2016 Oct 11;7(41):66700-66712
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 55184-1-AP( WNT5A-B Antibody) at dilution of 1:300
- Other comments
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 55184-1-AP( WNT5A-B Antibody) at dilution of 1:50 (under 10x lens)
- Other comments
- IHC