Ab134765

antibody from Aladdin Scientific Corporation

Targeting: WNT5A hWNT5A

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

Ab134765

Provider

Aladdin Scientific Corporation

Product name

Recombinant Wnt5a Antibody

Antibody type

Recombinant

Description

Rabbit anti Human Wnt5a Antibody, Recombinant (R08-4A3), could be used for WB, ICC, IF and so on.Application:WB: 1/500-1/1000ICC/IF: 1/50-1/200Protein FunctionLigand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

AA 340-354


Antibody clone number

R08-4A3

Vial size

100μl,10μl,1ml,50μl

Concentration

0,2 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.