Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
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Validation data
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- Product number
- AF1071 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal Cathepsin C/DPPI Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human Cathepsin C/DPPI in direct ELISAs and Western blots. In direct ELISAs,approximately 20% cross-reactivity with recombinant mouse Cathepsin C and recombinant rat Cathepsin C is observed and less than 1% cross-reactivity with recombinant human (rh) Cathepsin H and rhCathepsin X/Z/P is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Mutations in MAGT1 lead to a glycosylation disorder with a variable phenotype.
Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.
Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C.
Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.
Blommaert E, Péanne R, Cherepanova NA, Rymen D, Staels F, Jaeken J, Race V, Keldermans L, Souche E, Corveleyn A, Sparkes R, Bhattacharya K, Devalck C, Schrijvers R, Foulquier F, Gilmore R, Matthijs G
Proceedings of the National Academy of Sciences of the United States of America 2019 May 14;116(20):9865-9870
Proceedings of the National Academy of Sciences of the United States of America 2019 May 14;116(20):9865-9870
Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
Hamon Y, Legowska M, Hervé V, Dallet-Choisy S, Marchand-Adam S, Vanderlynden L, Demonte M, Williams R, Scott CJ, Si-Tahar M, Heuzé-Vourc'h N, Lalmanach G, Jenne DE, Lesner A, Gauthier F, Korkmaz B
The Journal of biological chemistry 2016 Apr 15;291(16):8486-99
The Journal of biological chemistry 2016 Apr 15;291(16):8486-99
Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.
Cherepanova NA, Shrimal S, Gilmore R
The Journal of cell biology 2014 Aug 18;206(4):525-39
The Journal of cell biology 2014 Aug 18;206(4):525-39
Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C.
Le QT, Min HK, Xia HZ, Fukuoka Y, Katunuma N, Schwartz LB
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 15;186(12):7136-43
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 15;186(12):7136-43
Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.
Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G, van der Wal T, Luinge M, Alvarez-Llamas G, Vos H, Poppema S, Vonk R, van den Berg A
Blood 2008 Feb 15;111(4):2339-46
Blood 2008 Feb 15;111(4):2339-46
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.
Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA
Genes & development 2006 Mar 1;20(5):543-56
Genes & development 2006 Mar 1;20(5):543-56
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human Cathepsin C/DPPI by Simple Western<SUP abp="262">TM. Detection of Human Cathepsin C/DPPI by Simple Western<SUP abp="262">TM.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human Cathepsin C/DPPI by Western Blot. Detection of Human Cathepsin C/DPPI by Western Blot.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Cathepsin C/DPPI in Human Lung Cancer Tissue. Cathepsin C/DPPI in Human Lung Cancer Tissue.