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- References [16]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10961-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10961-1-AP, RRID:AB_2274220
- Product name
- ARL3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ARL3 antibody (Cat. #10961-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3(T31A) and ARL3(T31A/C118F) mutations.
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Retinitis pigmentosa 2 pathogenic mutants degrade through BAG6/HUWE1 complex.
A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia.
ARL3 activation requires the co-GEF BART and effector-mediated turnover.
The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis.
ARL3 is downregulated and acts as a prognostic biomarker in glioma.
The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef.
Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.
Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.
Arl3 and LC8 regulate dissociation of dynactin from dynein.
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.
ADP-ribosylation factor-like 3, a manchette-associated protein, is essential for mouse spermiogenesis.
Ablation of the X-linked retinitis pigmentosa 2 (Rp2) gene in mice results in opsin mislocalization and photoreceptor degeneration.
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
Zhang X, Yao S, Zhang L, Yang L, Yang M, Guo Q, Li Y, Wang Z, Lei B, Jin X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23519
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23519
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J
Nature communications 2023 Apr 3;14(1):1840
Nature communications 2023 Apr 3;14(1):1840
Retinitis pigmentosa 2 pathogenic mutants degrade through BAG6/HUWE1 complex.
Zhang J, Gao H, Jiang N, Jing M, Sun Z, Du C, Zhang J, Wang M, Li J, Gao F, Hu Y, Mu H, Cui X
Experimental eye research 2022 Jul;220:109110
Experimental eye research 2022 Jul;220:109110
A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia.
Quidwai T, Wang J, Hall EA, Petriman NA, Leng W, Kiesel P, Wells JN, Murphy LC, Keighren MA, Marsh JA, Lorentzen E, Pigino G, Mill P
eLife 2021 Nov 4;10
eLife 2021 Nov 4;10
ARL3 activation requires the co-GEF BART and effector-mediated turnover.
ElMaghloob Y, Sot B, McIlwraith MJ, Garcia E, Yelland T, Ismail S
eLife 2021 Jan 13;10
eLife 2021 Jan 13;10
The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis.
Bhattarai SR, Begum S, Popow R, Ezratty EJ
Development (Cambridge, England) 2019 May 10;146(9)
Development (Cambridge, England) 2019 May 10;146(9)
ARL3 is downregulated and acts as a prognostic biomarker in glioma.
Wang Y, Zhao W, Liu X, Guan G, Zhuang M
Journal of translational medicine 2019 Jun 24;17(1):210
Journal of translational medicine 2019 Jun 24;17(1):210
The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Stephen LA, ElMaghloob Y, McIlwraith MJ, Yelland T, Castro Sanchez P, Roda-Navarro P, Ismail S
Developmental cell 2018 Oct 8;47(1):122-132.e4
Developmental cell 2018 Oct 8;47(1):122-132.e4
Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef.
Chase AJ, Wombacher R, Fackler OT
The Journal of biological chemistry 2018 May 18;293(20):7824-7840
The Journal of biological chemistry 2018 May 18;293(20):7824-7840
Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.
Zeng HL, Yu FL, Zhang Z, Yang Q, Jin S, He X, Chen X, Shen Y, Cheng L, Guo L, Xu F
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315
Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.
Konitsiotis AD, Roßmannek L, Stanoev A, Schmick M, Bastiaens PIH
Nature communications 2017 Jul 24;8(1):114
Nature communications 2017 Jul 24;8(1):114
Arl3 and LC8 regulate dissociation of dynactin from dynein.
Jin M, Yamada M, Arai Y, Nagai T, Hirotsune S
Nature communications 2014 Oct 24;5:5295
Nature communications 2014 Oct 24;5:5295
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.
Kim H, Xu H, Yao Q, Li W, Huang Q, Outeda P, Cebotaru V, Chiaravalli M, Boletta A, Piontek K, Germino GG, Weinman EJ, Watnick T, Qian F
Nature communications 2014 Nov 18;5:5482
Nature communications 2014 Nov 18;5:5482
ADP-ribosylation factor-like 3, a manchette-associated protein, is essential for mouse spermiogenesis.
Qi Y, Jiang M, Yuan Y, Bi Y, Zheng B, Guo X, Huang X, Zhou Z, Sha J
Molecular human reproduction 2013 May;19(5):327-35
Molecular human reproduction 2013 May;19(5):327-35
Ablation of the X-linked retinitis pigmentosa 2 (Rp2) gene in mice results in opsin mislocalization and photoreceptor degeneration.
Li L, Khan N, Hurd T, Ghosh AK, Cheng C, Molday R, Heckenlively JR, Swaroop A, Khanna H
Investigative ophthalmology & visual science 2013 Jul 2;54(7):4503-11
Investigative ophthalmology & visual science 2013 Jul 2;54(7):4503-11
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
Humbert MC, Weihbrecht K, Searby CC, Li Y, Pope RM, Sheffield VC, Seo S
Proceedings of the National Academy of Sciences of the United States of America 2012 Nov 27;109(48):19691-6
Proceedings of the National Academy of Sciences of the United States of America 2012 Nov 27;109(48):19691-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10961-1-AP(ARL3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 10961-1-AP(ARL3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 10961-1-AP(ARL3 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
