BS2187

CYP17A1 antibody from Bioworld Technology, Inc
CPT7, CYP17, P450C17, S17AH

Antibody data

Product number
BS2187
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS2187, RRID:AB_1663817
Product name
CYP17A1 (N249) polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS2187
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 211-260 of Human CYP17A1.
Description
CYP17A (17Ï«-hydroxylase/17,20-lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17Ï«-hydroxylation and the 17,20-lyase reaction.CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH-V) which is characterized by hypokalemia and hypertension.Male patients affected by AH-V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size (┬Ál)
100ul
Concentration (mg/ml)
1
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Provider Type Product Number
- No reagents -