Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60156 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- GJB5 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human GJB5.
- Description
- The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane Ï«-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1, Cx31.1 or Gap junction beta-5 protein, is a 271 amino acid protein that is predominantly expressed in skin with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC) and therefore it may be a potential therapeutic target.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of GJB5 pAb at 1:500 dilutionLane1:A549 whole cell lysateLane2:Raw264.7 whole cell lysateLane3:H9C2 whole cell lysate