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- Antigen structure
- References [10]
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- Western blot [1]
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- Product number
- 24103-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#24103-1-AP, RRID:AB_2737369
- Product name
- PCGF6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PCGF6 antibody (Cat. #24103-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.
Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells.
NUF2 Drives Clear Cell Renal Cell Carcinoma by Activating HMGA2 Transcription through KDM2A-mediated H3K36me2 Demethylation.
PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression.
The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development.
Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.
Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States.
MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6.
Weber LM, Jia Y, Stielow B, Gisselbrecht SS, Cao Y, Ren Y, Rohner I, King J, Rothman E, Fischer S, Simon C, Forné I, Nist A, Stiewe T, Bulyk ML, Wang Z, Liefke R
Nucleic acids research 2023 Jan 25;51(2):574-594
Nucleic acids research 2023 Jan 25;51(2):574-594
Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells.
Al Adhami H, Vallet J, Schaal C, Schumacher P, Bardet AF, Dumas M, Chicher J, Hammann P, Daujat S, Weber M
Nucleic acids research 2023 Apr 24;51(7):3130-3149
Nucleic acids research 2023 Apr 24;51(7):3130-3149
NUF2 Drives Clear Cell Renal Cell Carcinoma by Activating HMGA2 Transcription through KDM2A-mediated H3K36me2 Demethylation.
Lin J, Chen X, Yu H, Min S, Chen Y, Li Z, Xie X
International journal of biological sciences 2022;18(9):3621-3635
International journal of biological sciences 2022;18(9):3621-3635
PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression.
Lan X, Ding S, Zhang T, Yi Y, Li C, Jin W, Chen J, Liang K, Wang H, Jiang W
Nature communications 2022 Aug 6;13(1):4601
Nature communications 2022 Aug 6;13(1):4601
The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.
Stielow B, Zhou Y, Cao Y, Simon C, Pogoda HM, Jiang J, Ren Y, Phanor SK, Rohner I, Nist A, Stiewe T, Hammerschmidt M, Shi Y, Bulyk ML, Wang Z, Liefke R
Science advances 2021 May;7(20)
Science advances 2021 May;7(20)
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development.
Dahlet T, Truss M, Frede U, Al Adhami H, Bardet AF, Dumas M, Vallet J, Chicher J, Hammann P, Kottnik S, Hansen P, Luz U, Alvarez G, Auclair G, Hecht J, Robinson PN, Hagemeier C, Weber M
Nature communications 2021 Jun 11;12(1):3582
Nature communications 2021 Jun 11;12(1):3582
Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.
Mathsyaraja H, Catchpole J, Freie B, Eastwood E, Babaeva E, Geuenich M, Cheng PF, Ayers J, Yu M, Wu N, Moorthi S, Poudel KR, Koehne A, Grady W, Houghton AM, Berger AH, Shiio Y, MacPherson D, Eisenman RN
eLife 2021 Jul 8;10
eLife 2021 Jul 8;10
Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
Mochizuki K, Sharif J, Shirane K, Uranishi K, Bogutz AB, Janssen SM, Suzuki A, Okuda A, Koseki H, Lorincz MC
Nature communications 2021 Dec 2;12(1):7020
Nature communications 2021 Dec 2;12(1):7020
SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States.
Cossec JC, Theurillat I, Chica C, Búa Aguín S, Gaume X, Andrieux A, Iturbide A, Jouvion G, Li H, Bossis G, Seeler JS, Torres-Padilla ME, Dejean A
Cell stem cell 2018 Nov 1;23(5):742-757.e8
Cell stem cell 2018 Nov 1;23(5):742-757.e8
MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6.
Stielow B, Finkernagel F, Stiewe T, Nist A, Suske G
PLoS genetics 2018 Jan;14(1):e1007193
PLoS genetics 2018 Jan;14(1):e1007193
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PCGF6 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PCGF6. This antibody recognizes human antigen. The PCGF6 antibody has been validated for the following applications: ELISA, WB analysis.
