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- Antigen structure
- References [1654]
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- Product number
- 66031-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#66031-1-Ig, RRID:AB_11042766
- Product name
- alpha Tubulin antibody
- Antibody type
- Monoclonal
- Description
- Alpha Tubulin antibody (Cat. #66031-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, Canine and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1E4C11
- Vial size
- 150ul
Submitted references Paeoniflorin Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by SYK/SH3BP2 Signaling Pathway.
Exosomes Derived From Mesenchymal Stem Cells Regulating Myotube Cell Atrophy via NF-κB Signaling Pathway.
Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.
Antibody-induced internalization and degradation of PLA2R amplifies CD4(+) T cell activation.
SMURF2 attenuates NRF2-driven tumor progression by acting as a nuclear brake on NRF2 during cellular stress.
USP25 aggravates liver cancer development and impairs chemosensitivity by limiting LATS1 activation.
Tetraspanin CD82 shapes EGFR signaling outcomes through nanoscale receptor organization.
DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses.
Taohong siwu decoction alleviates hand-foot skin reaction by regulating RAGE-mediated keratinocyte apoptosis and autophagy.
Phenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling.
m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.
p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.
Trans-Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids.
Anxiety and abnormal hippocampal neurogenesis in adult rat offspring after high-speed train indoor pressure exposure during early pregnancy.
Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone-Mediated Autophagy.
Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide.
XIAP Stabilizes DDRGK1 to Promote ER-Phagy and Protects Against Noise-Induced Hearing Loss.
Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer.
Regulation of mitophagy by Fis1 and Fascin1-organized actin.
Combining Temozolomide with a Selective CK2 Inhibitor Results in Anti-Tumour Effects in Glioblastoma Cell Lines.
Remote Ischemic Preconditioning Exerts Neuroprotective Effects Via the PGC-1α/FNDC5/BDNF Pathway in Focal Brain Ischemia of Rats.
Trehalose ameliorates severe acute pancreatitis by modulating gut microbial metabolism.
A small‑molecule HDAC/PDE modulator activates human adipocyte UCP1 and resolves inflammatory signaling.
Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity.
Discovery of a Hydroxamic Acid-Based HDAC11 Isoform-Selective Inhibitor with Oral Anti-AML Potency.
CEP170 as a novel molecular link between centrosomal function and cerebral cortical development.
Ca(2+) influx through ER-plasma membrane contacts is required for brown fat thermogenesis and metabolic health.
Phytosterol alleviates cholesterol accumulation by influencing intestinal esterification rather than competitive solubilization under dietary MUFA.
A cell cycle-dependent transition of acetylation to phosphorylation regulates timely centrosome maturation.
MiR-1290 in natural killer cell derived extracellular vesicles: a pathogenic mediator of lupus nephritis and therapeutic target for th17 regulation.
HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
TONSL promotes hepatocellular carcinoma progression and radioresistance by orchestrating DNA damage repair and cell cycle dynamics.
Dual roles of GDNF in enteric glial cell plasticity: direct transdifferentiation via the CaMKII/NeuroD1 pathway and cooperative regulation in a neural stem cell-inducing medium.
Astrocyte-Specific Upregulation of Tumor Necrosis Factor Receptor II Ameliorates Pathological Phenotypes in APP(NL-F/NL-F) Mice.
Targeting HIF-1α promotes ferroptosis and boosts antitumor immunity in MSS colorectal cancer.
lncRNA-driven multi-omics reconstitution engineers EVs for macrophage-targeted and anti-inflammatory therapy in MASLD.
Matrix stiffness promotes corneal fibrosis through the YAP/TAZ-β-catenin mechanotransduction pathway: Proteomic and functional validation.
Tannic acid inhibits viral replication by disrupting nucleocapsid condensation.
HOMER3 as a prognostic and immune-related biomarker in pan-cancer and esophageal carcinoma: Insights from bioinformatics and functional validation.
Gossypol suppresses tumorigenesis through inhibition of multiple deubiquitinating enzymes.
Design, synthesis, and pharmacological evaluation of novel PROTAC degraders targeting 11β-HSD1 for metabolic disease intervention.
Lathyrane diterpenoids with anti-renal fibrotic activity from the aboveground parts of Euphorbia wallichii.
Disruption of the nucleocapsid-RNA condensation by punicalagin is a broad-spectrum antiviral approach.
Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer's disease.
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion.
Identification of a Novel Biallelic CFAP119 Variant in an Infertile Man with Asthenoteratozoospermia.
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
The Inhibition of PP1γ2 by PKA Through SRC Initiates Sperm Motility in Tree Shrews.
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion.
Bio-orthogonal chemistry-based strategy to Turn-OFF CRISPR-Cas9 activity in solution and live cells.
Astrocyte-specific deletion of ceruloplasmin exacerbates oxidative stress and demyelination in the spinal cord in a murine model of multiple sclerosis.
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels.
Paeoniflorin derivative ameliorates methotrexate resistance in treating rheumatoid arthritis through targeting GRK2-A(2A)AR axis.
Muskardia inhibits proliferation and migration of human coronary artery smooth muscle cells by regulating SLC7A11 mRNA stability via the hsa_circTEX10-PCBP2 Axis.
Licochalcone B targets neural cell adhesion molecule 1 to inhibit osteosarcoma progression and ferroptosis resistance via extracellular signal-regulated kinase 5 and nuclear factor kappa B pathways.
Therapeutic Targeting of the IRF9/RTN4/RHOA/ROCK Pathway via RVG29-Modified PLGA Nanoparticles and rTMS for Neural and Vascular Regeneration Post-Cerebral Infarction.
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex.
CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1-Mediated Ubiquitination of NPM1.
Herba Patriniae Component Linarin Induces Cell Cycle Arrest and Senescence in Non-Small-Cell Lung Cancer Associated with Cyclin A2 Downregulation.
High-content phenotyping reveals Golgi dynamics and their role in cell cycle regulation.
C-di-AMP sensitizes colorectal cancer to CD47 antibodies by activating NF-κB to promote macrophage phagocytosis.
DCLK1 drives malignant progression and chemoresistance of bladder cancer by deubiquitinating HDAC6.
Epicatechin Gallate Ameliorates UVB-Induced Photoaging by Inhibiting p38α-Mediated Autophagy and Oxidative Stress.
Mitochondria-located circRCP regulates redox homeostasis via stabilizing LRPPRC/SLIRP complex to promote bladder urothelial carcinoma tumorigenesis.
BMP6 as a therapeutic target for preeclampsia: enhancing trophoblast invasion and vascular mimicry.
Levistolide A Alleviates Myocardial Ischemia-Reperfusion Injury Partly by Improving Calcium Homeostasis via the ADORA2B/cAMP/PKA/PLB/SERCA2α Signaling Axis.
UBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment.
METTL16-m(6)A-PGC-1α axis contributes to exercise-induced mitochondrial adaptations in skeletal muscle of high-fat diet-fed insulin-resistant mice.
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle.
METTL14 integrates tumor-derived SAM to drive parabrachial epigenetic rewiring in pancreatic cancer.
TRPS1 confers paclitaxel resistance in TNBC through dual activation of the PDE4D-cAMP-AKT pathway and microtubule destabilization.
GRP75 blocks hepatitis E virus infection by targeting HEV-ORF2 for degradation through chaperone-mediated autophagy and promoting IRF3 activation.
Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1.
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
Ciliopathy-related B9 protein complex regulates ciliary axonemal microtubule posttranslational modifications and initiation of ciliogenesis.
A causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 GWAS locus influences susceptibility to schizophrenia.
A novel variant p.Y250C of FZD4 influences Norrine/β-catenin signaling pathway that associates with familial exudative vitreoretinopathy (FEVR).
Activation of the integrated stress response contributes to developmental delay and seizures caused by mitochondrial prolyl-tRNA synthetase (PARS2) deficiency.
Redox-dependent protein S-glutathionylation governs azacitidine sensitivity and resistance in AML.
Mechanistic Insights Into NFIX-Mediated DNA Recognition and Transcriptional Regulation in Skeletal Muscle.
TBKBP1 induces capecitabine resistance through negative regulation of type I interferon pathway in triple-negative breast cancer.
3'UTR shortening alleviates miRNA repression of mRNAs critical for muscle stem cell differentiation.
Treating acute respiratory distress syndrome with a multifaceted nanomedicine: Inhibition of PANoptosis and enhancement of lung barrier integrity.
Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells.
A novel PVA/QCS/AgNP hydrogel with antibacterial and healing-promoting efficacy for preventing postoperative pancreatic fistula in rats.
Rabeprazole attenuates fibrosis by modulating SMAD3 linker region phosphorylation.
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.
MD2 mediates COPD pathogenesis by inducing airway inflammation and ferroptosis through the TLR4/MyD88 pathway.
MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe.
Loss of Different Domains of TDRD12 Leads to Distinct Male Infertility-Related Phenotypes.
Effects of incompletely degraded galactomannan on growth performance and immune function of cyclophosphamide-induced immunosuppressed broilers.
Disruption of the NDC80-Nek2 axis suppresses glioblastoma stemness and enhances therapeutic efficacy.
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
Ginsenoside Rg5 Targets PRDX1 to Disrupt Redox Homeostasis and Induce Mitochondria-Dependent Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells.
SMYD3 synergises with RACK1 to promote colorectal cancer lung metastasis by recruiting SMAD3.
KLF7 as a biomarker for the pre-metastatic state promotes colorectal cancer liver metastasis via TGFβ autocrine signaling.
Comprehensive analysis identifies PKMYT1 as an oncogene and potential prognostic and immunological biomarker in lung adenocarcinoma.
Glioblastoma-secreted C1QL1 orchestrates tumor microtube expansion and neural synaptic pruning to drive malignant synapse formation and recurrence.
Molecular characterisation of the trafficking rescue of defective ABCB4 variants by roscovitine analogues.
DAXX governs the silencing of LINE1 during spermatogenesis in mice.
Single-Molecule Localization Expansion Nanoscopy via Spontaneously Blinking Fluorophores.
Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism.
PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis.
Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer.
Association of Variants in CDC10 (Septin 7) Gene with Growth-Related Traits in Qinchuan Cattle.
Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination.
Sodium butyrate promotes enteric glial cells neurogenesis by inhibiting Kdm2a and inducing Klf4 expression.
Remimazolam alleviates blood-brain barrier damage by regulating the PI3K/AKT signaling pathway in sepsis-associated encephalopathy mice.
CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis.
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin.
BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis.
A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks.
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains.
OTUB1 stabilizes PRRSV matrix protein through a non-canonical deubiquitination mechanism to promote viral replication.
Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation.
Template-driven scaffolding of SCF(FBXO42) regulates PP2A degradation.
Moxibustion delays ovarian aging by regulating mitochondrial biogenesis and improving oocyte quality.
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.
CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway.
Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer.
Multiaction Antimicrobial, Anti-inflammatory, and Prohealing Hydrogel as a Novel Strategy for Preventing Postoperative Pancreatic Fistula.
TGF-β1/SMAD3-mediated Non-canonical Hedgehog Signaling Promotes Pancreatic Stellate Cell Activation and Fibrosis in Chronic Pancreatitis.
RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells.
Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway.
Exploring the Therapeutic Mechanism of Jianpi Zhidong Decoction on Tourette Syndrome Based on Proteomics and Network Pharmacology.
Suppression of Inflammation by Si Miao San in Experimental Rheumatoid Arthritis Through Modulation of the AKT/ROS/Autophagy Axis.
Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization.
A tumor immune microenvironment gene expression signature for predicting prognosis, immunotherapy efficacy, and drug candidates in triple-negative breast cancer.
Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism.
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer.
The type I ribosome-inactivating protein α-MMC induced significant apoptosis of lung cancer A549 and 95-D cells by activating the caspase cascade through TNF signaling pathway.
Peptostreptococcus anaerobius promotes cervical cancer angiogenesis by upregulating SCD to activate ERK pathway.
Comprehensive exome profiling identifies ARHGEF12 mutation as a driver in gastric cancer with ovarian metastasis.
SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.
Aberrant sialic acid metabolism promotes metabolic reprogramming and metastasis in breast cancer.
Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML.
Screening and identification of protein 29 of Echinococcus granulosus interacting molecules.
Recombinant Antithrombin Alleviated Pulmonary Injury and Inflammation in LPS-Induced ARDS by Inhibiting IL17a/NF-κB Signaling.
Melk facilitates pulmonary artery smooth muscle cell proliferation and migration in pulmonary hypertension via modulation of YAP/TAZ signaling.
An integrative pan-cancer analysis of USP37 and functional validation in pancreatic cancer.
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice.
Polycyclic Polyprenylated Acylphloroglucinols from Hypericum himalaicum.
GSK3A promotes human adenovirus replication and phosphorylates viral L4-22K protein.
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma.
Deubiquitinase-dependent transcriptional silencing controls inflammation.
Tumor-derived exosome-based microRNA-206 delivery system as dual modulators of the immune microenvironment and gut microbiota for colorectal cancer therapy.
Roles of human SPATA3 in cell proliferation and expression pattern of Spata3 in mouse testis.
NMDA-Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1-TBX3-Nav1.5 Axis.
Potent Anti-Cancer Activity of Benzo[d]Thiazole-Isatin Conjugates: Induces S Phase Arrest and Cell Necrosis in A549 and HepG2 Cells.
Exosome-mediated microglia-astrocyte interactions drive neuroinflammation in Parkinson's disease with Peli1 as a potential therapeutic target.
Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Sex hormone-binding globulin restrains hepatic fibrosis via inhibition of Tgfβ expression.
A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage.
Single-cell RNA sequencing identifies a unique ZEB2-Regulated Clec4d(+) macrophage state contributing to early inflammatory injury in cardiac hypertrophy.
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.
NCAPH-YAP1 interaction promotes breast cancer stemness and tumor progression.
Human cytomegalovirus promotes de novo PC synthesis during early virus replication.
Phosphorylation enables progressive microtubule-associated protein proteolysis and functionalisation during neural development.
Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response.
Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers.
Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.
Polystyrene nanoplastics promote muscle cell senescence through microtubule hyper-stabilization-mediated mitophagy dysfunction and cGAS-Sting activation.
Thyroid hormone ameliorates ursodeoxycholic acid-induced heart damage in zebrafish embryos.
Erucic acid impairs male fertility by suppressing retinoic acid synthesis in sertoli cells.
Exposure to diethyl phthalates impairs ovarian reserve and oocyte maturation in female mice.
Discovery of indole derivatives as STING degraders.
Loss of TEX30 leads to male subfertility in mice.
Papain-like protease of SARS-CoV-2 inhibits dsRNA-induced type I interferon response partly by cleaving TBK1.
Chemical coupling of an active/passive dual-targeting fusion protein ER(Fv)-HSA to DM1 improves its tumor-specificity and therapeutic efficacy against pancreatic cancer.
Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis.
Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer.
Pregnane X Receptor Activation Induces Ferroptosis Resistance Through Upregulation of FSP1.
Neuroprotective Effect of Salvianolic Acid C in Neonatal Rats Following Hypoxic-ischemic Brain Damage.
Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases.
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis.
KDM1A-driven RNF81 downregulation promotes gastric cancer progression via KLF4 destabilization.
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Downregulation of miR-127-5p promotes idiopathic epiretinal membrane development via GLUL-mediated Müller cell activation.
Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications.
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.
Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis.
Electroacupuncture combined with subanesthetic alfaxalone as a novel target for alleviating neuropathic pain.
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer.
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity.
10-Hydroxy-2-decenoic acid ameliorates LPS-induced acute lung injury through targeting MD2-mediated inflammatory signaling pathways.
Multidimensional analysis of hsa-miR-140-3p and CKS1B correlation via the MAPK/ERK pathway in lung adenocarcinoma progression.
Reactive Oxygen Species (ROS) Drive Osteocyte Dysfunction in Diabetic Osteoporosis by Impairing Autophagy and Triggering Apoptosis.
Mitotic DNA repair by TMEJ suppresses replication stress-induced nuclear envelope reassembly defect.
CRL4(DCAF12) regulation of MCMBP ensures optimal licensing of DNA replication.
HuoXue QianYang QuTan recipe attenuates myocardial hypertrophy in obese hypertensive rats by regulating MPC1/MCT4 mediated pyruvate-lactate metabolic axis.
Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model.
Molecules interacting with CasL-Like 2 enhances tumor angiogenesis and progression by activating mTOR/HIF1α/VEGF pathway in kidney renal clear cell carcinoma.
Synthetic Multidomain Proteins Containing Unstructured and α‑Helical Linkers Reveal a Differential Impact of Molecular Crowding on Catalytic Activity and Conformation.
Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.
RIPK4 promotes epidermal differentiation through phase separation and activation of LATS1/2.
Licochalcone D Alleviates Radiation-Induced Intestinal Injury via SIRT3-Dependent Mitophagy: A Natural Phytochemical Strategy for Radioprotection.
Metformin activates autophagy and inhibits apoptosis and fetal heart abnormalities via the Dnmt3l/Usp18/STAT1 pathway.
11α-hydroxyprogesterone dampens lung metastasis via EMT modulation in PyMT-induced breast cancer murine model.
Blockade of TGF-β1/Smad3 signaling pathway by Bovine Milk-derived extracellular vesicles ameliorates skin fibrosis in systemic sclerosis mice.
NEK7 mediates ESRD-associated endothelial injury by activating the NLRP3 inflammasome.
Actomyosin forces trigger a conformational change in desmoplakin within desmosomes.
Suppressor of Tumorigenicity 14 inhibits non-small cell lung cancer cell proliferation by suppressing Transketolase O-GlcNAcylation.
Mitochondrial DNA-driven senescence-associated secretory phenotype promotes the development of bronchopulmonary dysplasia.
KPNA2 silencing sensitizes triple-negative breast cancer to chemotherapy by promoting multipolar division and suppressing DNA damage repair.
FTDC1/2, oocyte-specific cofactors of DNMT1 required for epigenetic regulation and embryonic development.
CHIP/STUB1 suppresses the transcription and latent reactivation of HIV-1 via the TRAF6-NF-κB-HIV-LTR axis.
Obacunone ameliorates high-fat diet-induced MAFLD by regulating the PPARγ-FABP1/CD36 axis and the gut-liver crosstalk.
CERKL Reduced PI3P/Autophagy to Promote Pancreatic Cancer.
Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia-Induced Stress Granule Formation.
Glabridin-Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity.
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling.
FPR1-dependent Pro-inflammatory Ccl4(high) monocytes/macrophages drive and predict sepsis-induced acute lung injury.
Structural insights into antagonist recognition by the vasopressin V2 receptor.
Microglial Nrf2 Functions as a Cell-Autonomous Regulator of Neuroinflammation and Trained Immunity in the Aging Brain.
Cell-type-specific dysregulation of mitochondrial calcium signaling in Alzheimer's disease.
Targeting Cathepsin B-mediated pyroptosis in fibroblasts alleviate ultraviolet-induced skin inflammation and injury.
FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation.
tiRNA: An efficient and controllable gene silencing technology via translation inhibition.
Identification of ATG7 as a protein ATG8ylation substrate.
SOS1 inhibition suppresses the emergence of osimertinib resistance to generate a durable response in EGFR-mutant lung cancer.
Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells.
Spermidine enhances macrophages anti-inflammatory and regenerative functions by improving mitochondrial fitness.
LRP12 promotes gastric cancer progression through AKT/mTOR signaling and M2 macrophage-mediated immunosuppression.
MRAP mediated adipocyte differentiation by thymic mesenchymal stromal cells contributes to thymic involution.
Curcumin Analogues Trigger HMOX1-Mediated Ferroptosis to Halt Endometrial Cancer Growth.
Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis.
The VCPKMT-VCP-HDAC1 axis inhibits colorectal cancer by conferring sensitivity to ferroptosis.
Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer.
SARS-CoV-2 ORF7a activates the endothelium to release von Willebrand factor that promotes thrombosis.
Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage-Dependent Anion Channel 1-Mediated Mitochondrial Dysfunction.
Dendrimer nanocarriers for targeted co-delivery of MiR-146b-3p and 5-ALA to synergistic photodynamic therapy in secondary hyperparathyroidism.
Histone acetyltransferase BmMOF inhibits the proliferation of the Bombyx mori nucleopolyhedrovirus by targeting Bmp53.
Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma.
Formosanin C inhibits triple-negative breast cancer progression by suppressing the phosphorylation of STAT3 and the polarization of M2 macrophages.
The involvement of thioredoxin reductase genes in development, reproduction and deltamethrin tolerance in the red flour beetle, Tribolium castaneum.
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia.
ERK pathway reactivation prevents anthrax toxin lethality in mice.
Serum-free endothelial cell culture medium for vascular smooth muscle cells sheet formation.
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Mechanobiological mechanism of cyclic stretch-induced cell columnarization.
Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes.
MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1.
Aberrant downregulation of Y-box binding protein 1 expression impairs the cell cycle in an m(5)C-dependent manner in human granulosa cells from patients with primary ovarian insufficiency.
Selenoprotein K Confers Protection against Iron Dyshomeostasis-Related Neurotoxicity by Regulating the Palmitoylation of TfR-1.
Liquiritigenin protects against cadmium-induced testis damage in mice by inhibiting apoptosis and activating androgen receptor.
PRMT1-catalyzed NUSAP1 methylation enhances Notch2 signaling and 5-FU resistance in gastric cancer.
ML210 Antagonizes ABCB1- Not ABCG2-Mediated Multidrug Resistance in Colorectal Cancer.
Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression.
Benzbromarone interferes with the interaction between Hsp90 and Aha1 by interacting with both of them.
Prkra dimer senses double-stranded RNAs to dictate global translation efficiency.
De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma.
Functional characterization of a novel protein-coding circular RNA, circRNA_1193, from the mAAP gene in silkworm and its role in antiviral defense against BmCPV.
Effects of Ninjin'yoeito and physical exercise on serum corticosterone and hippocampal BDNF/proBDNF and neuroinflammation in post-stroke depression in rats.
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Sex hormone-binding globulin dampens growth and metastasis of breast cancer in an estrogen-independent manner.
Diurnal Variation in Melatonin-Mediated Cardiac Protection via Per2 Expression in Heart.
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation.
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.
Identification of chemical inhibitors targeting long noncoding RNA through gene signature-based high throughput screening.
DSTYK phosphorylates STING at late endosomes to promote STING signaling.
The natural product micheliolide promotes the nuclear translocation of GAPDH via binding to Cys247 and induces glioblastoma cell death in combination with temozolomide.
HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis.
The NLRP3 activation-related signature predicts the diagnosis and indicates immune characteristics in endometriosis.
HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism.
The polarization of macrophages participates in the repair after folic acid-induced acute kidney injury.
NUB1 reduction promotes PCNA-mediated tumor growth by disturbing the PCNA polyubiquitination/NEDDylation in hepatocellular carcinoma cells.
Development of Novel Peptide-Based Radiotracers for Detecting FGL1 Expression in Tumors.
Bio-SS-TS as a Targeted Antitumor Drug Exerts an Anti-Liver Cancer Effect by Enhancing Mitochondria-Dependent Apoptosis.
Perturbed cell fate decision by schizophrenia-associated AS3MT(d2d3) isoform during corticogenesis.
Role of declined electrogenic Na(+)/HCO(3)(-) cotransporter NBCe1 in mucus barrier impairment and colonic inflammation.
ACLY inhibitor reduced Porphyromonas gingivalis-induced pyroptosis by suppressing microtubules acetylation in macrophages.
Compositionally unique mitochondria in filopodia support cellular migration.
ATP8A1-translocated endosomal phosphatidylserine fine-tunes the multivesicular body formation and the endo-lysosomal traffic.
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice.
The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation.
Integrated Multiomics Analyses Reveal Molecular Insights into How Intermittent Fasting Ameliorates Obesity and Increases Fertility in Male Mice.
Huachansu suppresses colorectal cancer via inhibiting PI3K/AKT and glycolysis signaling pathways: Systems biology and network pharmacology.
Blueberry Anthocyanin Extracts (BAEs) Protect Retinal and Retinal Pigment Epithelium Function from High-Glucose-Induced Apoptosis by Activating GLP-1R/Akt Signaling.
Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC.
Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer.
Inhibition of Bif-1 confers cardio-protection in myocardial infarction.
FOXM1, a super enhancer-associated gene, is related to poorer prognosis and gemcitabine resistance in pancreatic cancer.
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion.
Irisin reverses high-fat diet-induced metabolic dysfunction via activation of brown adipose tissue in mice.
A positive feedback loop of OTUD1 and c-Jun driven by leptin expedites stemness maintenance in ovarian cancer.
Activation of GPER1 alleviates white matter injury by promoting microglia M2 polarization through EGFR/Stat3 pathway in intracerebral hemorrhage mice.
The critical role of transcription factor GATA1 in erythrocyte proliferation and morphology in blood clam Anadara granosa.
Ubiquitin-specific protease 21 aggravates enterovirus 71 (EV71) infection by restricting Lys48-linked ubiquitination of EV71-2A protease.
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.
Reproductive-Triggered Sterol Competition Exacerbates Age-Related Intestinal Barrier Damage in Drosophila Females.
Doxorubicin-induced senescence is modulated by the eukaryotic release factor 3a and its polyglycine expansion in HCT116 cells.
Curcumin modulates β-catenin stabilization via targeting proteasomal deubiquitinating enzyme USP14(☆).
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
rTMS ameliorates CUMS-induced anxiety-depression-like behaviour and cognitive dysfunction in rats by modulating the COX-2/PGE2 signalling pathway.
Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS-PAGE with low acrylamide concentration.
Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN-m5f cells.
Establishment and biological characterization of radioresistant colorectal cancer cell lines.
Chromosomal integrity of freeze-dried karyoplasts in mice.
Dual-omics analysis of transcriptome and translatome unveils lycopene-induced triglyceride accumulation mechanisms in muscle cells.
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
Can linc00968 Regulate SH-SY5Y Cell Apoptosis Induced by Amyloid beta Neurotoxicity?
Clearance of protein aggregates during cell division.
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL.
Transcription factors FOXN1 and intrathymic cytokines contribute to dysfunction of TECs during lipopolysaccharide-induced thymic atrophy.
Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway.
Txnip/Trx Is a Potential Element in Regulating O-GlcNAc Modification in Photoreceptors to Alleviate Diabetic Retinopathy.
HELQ Maintains Genome Stability of Primordial Germ Cells by Inhibiting LINE-1 Expression.
GCRV-II Triggers B and T Lymphocyte Apoptosis via Mitochondrial ROS Pathway.
Oncometabolite fumarate facilitates PD-L1 expression and immune evasion in clear cell renal cell carcinoma.
HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes.
BST2 and DIRAS3 Drive Immune Evasion and Tumor Progression in High-Grade Glioma.
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Shedding of GPP130 by PC7 and Furin: Potential Implication in Lung Cancer Progression.
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.
SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes.
Hypoxia upregulates the expression of PD-L1 via NPM1 in breast cancer.
Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain.
Ancestry-linked stromal variations impact breast epithelial cell invasion.
Birth of protein-coding exons by ancient domestication of LINE-1 retrotransposon.
WISP2/CCN5 revealed as a potential diagnostic biomarker for endometriosis based on machine learning and single-cell transcriptomic analysis.
ANP32 proteins from ticks and vertebrates are key host factors for replication of Bourbon virus across species.
YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formation.
Neurotransmitter imbalance and amygdala synaptic plasticity in lumbar disc herniation-induced chronic pain and related emotional Disturbances:A multi-omics analysis.
Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific.
Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model.
Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells.
Discovery of novel selective HDAC6 inhibitors via a scaffold hopping approach for the treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo.
Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells.
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.
NEIL3 Deficiency Enhances HCC Cell Sensitivity to Oxaliplatin by Inhibiting the Fanconi Anaemia Pathway.
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
CD36 promotes iron accumulation and dysfunction in CD8+ T cells via the p38-CEBPB-TfR1 axis in early-stage hepatocellular carcinoma.
Investigating shared diagnostic genes and mechanisms between metabolic syndrome and dry eye disease via integrated bioinformatics analysis and in vivo validation.
Discovery of a novel BCL-2 inhibitor GW806742X for the treatment of TNBC.
Boron neutron capture therapy with pteroyl-closo-dodecaborate-conjugated 4-(p-iodophenyl)butyric acid (PBC-IP) for a head and neck squamous cell carcinoma (SAS) model mice.
Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection.
Aldolase A accelerates hepatocarcinogenesis by refactoring c-Jun transcription.
Refined qingkailing attenuates reactive astrocytes and glial scar formation after ischemia stroke via the EGFR/PLCγ pathway.
ADAM Sheddase Activity Promotes the Detachment of Small Extracellular Vesicles From the Plasma Membrane.
Ultrasound-Guided Functionalized Extracellular Vesicles for Visualized, Controlled, and Efficient Renal Delivery for Enhanced Kidney Repair.
PP2Acα regulates sleep amount and sleep homeostasis in mice.
Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling the immune microenvironment.
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer.
The proximity proteome of pre-40S pre-ribosomal particle components PNO1 and NOB1 using turboID proximity labeling technology.
Discovery of 3,4-dihydropyrimidine derivatives as novel Anti-PEDV agents targeting viral internalization through a unique calcium homeostasis disruption mechanism.
The Effects of Different Types of Exercise on Pulmonary Inflammation and Fibrosis in Mice with Type 2 Diabetes Mellitus.
Loss of C-Terminal Coiled-Coil Domains in SDCCAG8 Impairs Centriolar Satellites and Causes Defective Sperm Flagellum Biogenesis and Male Fertility.
C20orf27 promotes hepatocellular carcinoma progression via NT5E.
Deficiency of Rab26 causes behavioral defects in mice through impaired trafficking of serotonin (5-HT) transporter.
PKA-mediated BMAL1 phosphorylation promotes β(1)-adrenoceptor autoantibody-induced cardiomyocyte death.
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Valosin-containing protein mediates DNA-dependent protein kinase activation in response to DNA topoisomerase II-associated DNA double-strand breaks.
Positional BMP signaling orchestrates villus length in the small intestine.
AK4 promotes nasopharyngeal carcinoma metastasis and chemoresistance by activating NLRP3 inflammatory complex.
Discovery of structurally diverse diazatricyclododecenes as lysosomotropic autophagy inhibitors.
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture.
Interaction Between Aging-Related Elastin-Derived Peptide (VGVAPG) and Sirtuin 2 and its Impact on Functions of Human Neuron Cells in an In Vitro Model.
A novel regulatory axis of MSI2-AGO2/miR-30a-3p-CGRRF1 drives cancer chemoresistance by upregulating the KRAS/ERK pathway.
Correspondence to editorial on "UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL".
LAPTM5 Confers the Resistance to Venetoclax via Promoting the Autophagosome-Lysosome Fusion in Multiple Myeloma.
β-fructofuranosidase regulation in silkworm silk gland development: Implications for silk gland morphogenesis and silk production.
Ketogenic β-hydroxybutyrate regulates β-hydroxybutyrylation of TCA cycle-associated enzymes and attenuates disease-associated pathologies in Alzheimer's mice.
HO-1-mediated ferroptosis regulates retinal neovascularization via the COX2/VEGFA axis.
LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.
GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes.
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1.
Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity.
D-ribose-5-phosphate inactivates YAP and functions as a metabolic checkpoint.
Rostellularia procumbens (L) Nees. extract attenuates adriamycin-induced nephropathy by maintaining mitochondrial dynamics balance via SIRT1/PGC-1α signaling pathway activation.
Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma.
Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.
Extracellular vesicles from adipose-derived stem cell alleviate diabetic cardiomyopathy by regulating Chit1/NLRP3/Caspase-1-Mediated pyroptosis.
A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer.
Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation.
SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma.
The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis.
Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R-Ca(2+)-PIK3CA pathway.
Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer.
Abnormal methylation of Mill1 gene regulates osteogenic differentiation involved in various phenotypes of skeletal fluorosis in rats and methionine intervention.
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3.
Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor.
Application of genome tagging technology in elucidating the function of sperm-specific protein 411 (Ssp411).
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance.
Novel variants in DNAH9 are present in two infertile patients with severe asthenospermia.
Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice.
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Nicotinamide n-methyltransferase inhibitor synergizes with sodium-glucose cotransporter 2 inhibitor to protect renal tubular epithelium in experimental models of type 2 diabetes mellitus.
Acute heat stress upregulates Akr1b3 through Nrf-2 to increase endogenous fructose leading to kidney injury.
Artificial targeting of autophagy components to mitochondria reveals both conventional and unconventional mitophagy pathways.
The Stimulator of Interferon Genes Deficiency Attenuates Diabetic Myopathy Through Inhibiting NLRP3-Mediated Pyroptosis.
Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer.
Deciphering TCOF1 mutations in Chinese Treacher Collins syndrome patients: insights into pathogenesis and transcriptional disruption.
A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice.
ApoE2 affects insulin signaling in the hippocampus and spatial cognition of aged mice in a sex-dependent manner.
Membrane-tethered SCOTIN condensates elicit an endoplasmic reticulum stress response by sequestering luminal BiP.
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3.
One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study.
UFMylation maintains YAP stability to promote vascular endothelial cell senescence.
Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis.
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.
Differential Mechanisms of Soybean-Derived ACE2-Activating Peptides IVPQ and IAVPT in ACE2-Mediated Endothelial Protection.
Sephin1 suppresses ER stress-induced cell death by inhibiting the formation of PP2A holoenzyme.
Impact of physiological ionic strength and crowding on kinesin-1 motility.
Tumour-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via the PI3K/Akt/mTOR pathway.
LRRC56 deletion causes primary ciliary dyskinesia in mice characterized by dynein arms defects.
Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.
Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression.
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Pre-chelated gallium-loaded polydopamine nanoparticles as a multifunctional regulator of osteoblast/osteoclastogenesis for the synergistic therapy of periodontitis.
Tumor PLA2G10 restrains CD4(+) T cell activation in lung adenocarcinoma via enhancing arachidonic acid secretion.
Bovine tubulin cofactor D (TBCD) disrupts tubulin dimers and inhibits tumor growth via the TNF-α signaling pathways-mediated ROS production.
Elongator subunit Elp3 regulates reproduction in Tribolium castaneum by interacting with FOXO.
A novel dual CDC25-HDAC inhibitor suppresses glioblastoma progression via chromosomal passenger complex disruption.
Bombyx mori nucleopolyhedrosis virus-derived circular RNAs with protein-coding potential facilitate viral replication.
Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway.
Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1.
Oncofetal dual‑specificity phosphatase 9 drives stem-like properties through ERK1/2-PPARG-SCD axis-mediated lipid metabolism in hepatocellular carcinoma.
Mass Spectrometry-Based Proteomic Analysis of Porcine Reproductive and Respiratory Syndrome Virus NSP9 Protein with Host Proteins.
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence.
Multi-Omics Analysis Reveals Distinct Lipid Remodelling and Mitochondrial Stress in SH-SY5Y Cells Modelling Parkinson's Disease.
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
PRAS40 promotes colorectal cancer stemness by enhancing glycolysis through triggering PGK1 acetylation.
SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3's activity and promotes lung tumorigenesis.
TRIM29 inhibits PRRSV replication by targeting nsp11 for degradation.
DHX36 plays an oncogenic role in breast cancer progression and invasiveness.
Decreased scleral Wnt5a(hi) fibroblasts exacerbate myopia progression by disrupting extracellular matrix homeostasis in mice.
Pathogenic Mechanism of the KCNQ4 Gene Variant in Hearing Loss and Functional Validation in a Zebrafish Model.
The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution.
RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether.
Sodium disrupts mitochondrial energy metabolism to execute NECSO.
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia.
Knockdown of MiD49 and MiD51 alleviates collagen-induced arthritis and suppresses mitophagy and fatty acid oxidation (FAO) in rheumatoid arthritis fibroblast-like synoviocytes.
LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.
Shank3 Regulates L-Type Voltage-Gated Ca(2+) Channels in the Mouse Striatum and Hippocampus at the Early Developmental Stage.
The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response.
HDGF derived from Müller cells enhances the activation of microglia in diabetic retinopathy.
PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules.
OFD1 inhibition induces BRCAness to create a therapeutic vulnerability to PARP inhibition in pancreatic cancer.
Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth.
The Synergistic Role of P2rx7 and Panx1 in Regulating Alveolar Macrophage Pyroptosis and Exosome-Mediated Ferroptosis of Alveolar Epithelial Cells in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
Evidence that mitochondria in macrophages are destroyed by microautophagy.
Sex-Specific Differences in the Revascularization of Grafted Pancreatic Islets.
STAT3 haploinsufficiency is associated with autosomal dominant hyper-IgE syndrome.
Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH.
Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma.
HMGB1/RAGE signaling mediates the activation of microglia and participates in depressive-like behaviors and cognitive deficits in rats after ischemia-reperfusion.
Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching.
Paclitaxel neurotoxicity is triggered by epidermal EG5-dependent microtubule fasciculation and X-ROS formation.
Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications.
PDE4D Regulates Mitochondrial Homeostasis and Adult Hippocampal Neurogenesis via the cAMP/CREB Signaling Pathway in Chronic Stress-Induced Depressive-Like Behavior.
Inhibiting ANP32E protects against acute kidney injury by regulating autophagy via the AMPK pathway.
Mitochondria protect against an intracellular pathogen by restricting access to folate.
M-Sec Overexpressed Stem Cells Growing Abundant Tunneling Nanotubes for Diverse Active Transferring.
A casein-derived peptide exerted immunomodulatory effects by targeting protein phosphatase 1-catalytic subunit alpha: a potential alternative to combat infections.
Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression.
Codelivery of NGFR100W and VEGFA mRNA Enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy.
FOXK1 promotes hormonally responsive breast carcinogenesis by suppressing apoptosis.
NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling.
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
Enzymatic degraded polysaccharides from Enteromorpha prolifera inhibit the growth of THP-1 cells and induce apoptosis via the mitochondrial pathway.
The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins.
Targeting GPX4 alleviates ferroptosis and retards abdominal aortic aneurysm formation.
β-hydroxybutyrylation and O-GlcNAc modifications of STAT1 modulate antiviral defense in aging.
EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA.
ATP depletion in anthrax edema toxin pathogenesis.
circEgg inhibits BmCPV infection by regulating the transition between H3K9me3 and H3K9ac.
Zika and dengue viruses differentially modulate host mRNA processing factors defining its virulence.
Isovaleroylbinankadsurin A ameliorates atherosclerosis and restenosis by promoting LXRα signaling pathway and inhibiting TGF-β1 and FHL1 signaling pathways.
Deciphering the role of ELAVL1: Insights from pan-cancer multiomics analyses with emphasis on nasopharyngeal carcinoma.
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases.
Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING-Mediated Glycolysis.
Effects of cellular membranes and the precore protein on hepatitis B virus core particle assembly and DNA replication.
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure.
Coevolving residues distant from the ligand binding site are involved in GAF domain function.
Deletion of HIF-2α in Dendritic Cells Attenuates Anti-Glomerular Basement Membrane Nephritis.
Targeting the liquid-liquid phase separation of nucleocapsid broadly inhibits the replication of SARS-CoV-2 strains.
Trifluridine/tipiracil induces ferroptosis by targeting p53 via the p53-SLC7A11 axis in colorectal cancer 3D organoids.
Prognostic model of osteosarcoma based on telomere-related genes and analysis of immune characteristics.
Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer.
Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by Sox9+ tumor cells interaction with Fpr1+ neutrophils.
HDAC11 Inhibition as a Potential Therapeutic Strategy for AML: Target Identification, Lead Discovery, Antitumor Potency, and Mechanism Investigation.
Keto Acids Attenuate Skeletal Muscle Atrophy in Chronic Kidney Disease via Inhibiting Pyroptosis and Upregulating Irisin Precursor FNDC5 Expression.
Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body.
The structural protein VP3 of enterovirus D68 interacts with MAVS to inhibit the NF-κB signaling pathway.
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity.
Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13.
The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation.
LRG1 promotes the apoptosis of pulmonary microvascular endothelial cells through KLK10 in chronic obstructive pulmonary disease.
Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.
IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.
Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic Retinopathy.
ESM1 facilitates the EGFR/HER3-triggered epithelial-to-mesenchymal transition and progression of gastric cancer via modulating interplay between Akt and angiopoietin-2 signaling.
Enhancing mitophagy by ligustilide through BNIP3-LC3 interaction attenuates oxidative stress-induced neuronal apoptosis in spinal cord injury.
Medioresinol from Eucommiae cortex improves myocardial infarction-induced heart failure through activation of the PI3K/AKT/mTOR pathway: A network analysis and experimental study.
Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer.
Ninjin'yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice.
Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo.
Mitochondrial DNA drives neuroinflammation through the cGAS-IFN signaling pathway in the spinal cord of neuropathic pain mice.
Surgery induces neurocognitive disorder via neuroinflammation and glymphatic dysfunction in middle-aged mice with brain lymphatic drainage impairment.
Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer.
miR-141-3p promotes paclitaxel resistance by attenuating ferroptosis via the Keap1-Nrf2 signaling pathway in breast cancer.
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.
Pan-cancer analysis and experimental validation of FPR3 as a prognostic and immune infiltration-related biomarker for glioma.
Neuron stress-related genes serve as new biomarkers in hypothalamic tissue following high fat diet.
Liquiritin ameliorates painful diabetic neuropathy in SD rats by inhibiting NLRP3-MMP-9-mediated reversal of aquaporin-4 polarity in the glymphatic system.
Phosphoenolpyruvate carboxykinase 2-mediated metabolism promotes lung tumorigenesis by inhibiting mitochondrial-associated apoptotic cell death.
Critical role of G3BP1 in bovine parainfluenza virus type 3 (BPIV3)-inhibition of stress granules formation and viral replication.
Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway.
Caspase-mediated AURKA cleavage at Asp(132) is essential for paclitaxel to elicit cell apoptosis.
Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells.
Decreased expression of LncRNA CRYM-AS1 promotes apoptosis through the Hippo-YAP1 signaling pathway leading to diabetic erectile dysfunction.
Bone marrow stromal and anterior cruciate ligament remnant cell co-culture-derived extracellular vesicles promote cell activity in both cell types.
DCAF7 Acts as A Scaffold to Recruit USP10 for G3BP1 Deubiquitylation and Facilitates Chemoresistance and Metastasis in Nasopharyngeal Carcinoma.
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Effect of lyophilized exosomes derived from umbilical cord stem cells on chronic anterior cruciate ligament cell injury.
Dihydromyricetin ameliorates diabetic renal fibrosis via regulating SphK1 to suppress the activation of NF-κB pathway.
12-HETE/GPR31 induces endothelial dysfunction in diabetic retinopathy.
SLC7A11-mediated cystine import protects against NDUFS7 deficiency-induced cell death in HEK293T cells.
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
The oncogenic ADAMTS1-VCAN-EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma.
AntigenBoost: enhanced mRNA-based antigen expression through rational amino acid substitution.
Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production.
Liquid-liquid phase separation is essential for reovirus viroplasm formation and immune evasion.
Interleukin-1 increases SERPINE1 expression in human granulosa-lutein cell via P50/P52 signaling pathways.
Nuclear translocation of nucleotide enzyme Phosphoglucomutase 2 governs DNA damage response and anti-tumor immunity.
Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer.
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke.
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance.
Ceftazidime is a potential drug to inhibit cell proliferation by increasing cellular p27.
Insulin-transferrin-selenium promote formation of tissue-engineered vascular grafts in early stage of culture.
COLEC10 inhibits the stemness of hepatocellular carcinoma by suppressing the activity of β-catenin signaling.
EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β.
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
TRAF2 associates with cullin neddylation complex assembly.
LncRNA MFRL regulates the phenotypic switch of vascular smooth muscle cells to attenuate arterial remodeling by encoding a novel micropeptide MFRLP.
Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling.
Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis.
Cyclopeptide Inhibitors Target the N-Terminal Tail of STING and Alleviate Autoinflammation.
BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer.
Lysine lactylation-based insight to understanding the characterization of cervical cancer.
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model.
NEK10 kinase ablation affects mitochondrial morphology, function and protein phosphorylation status.
Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation.
High androgen level during controlled ovarian stimulation cycle impairs endometrial receptivity in PCOS patients.
A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.
CHIP drives proteasomal degradation of NUR77 to alleviate oxidative stress and intrinsic apoptosis in cisplatin-induced nephropathy.
Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response.
C/EBPα-mediated ACSL4-dependent ferroptosis exacerbates tubular injury in diabetic kidney disease.
Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus.
Polystyrene microplastics trigger testosterone decline via GPX1.
An optofluidic system for the concentration gradient screening of oocyte protection drugs.
Dimethyl Sulfoxide Attenuates Ionizing Radiation-induced Centrosome Overduplication and Multipolar Cell Division in Human Induced Pluripotent Stem Cells.
Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition.
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation.
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress.
The small GTPase Cdc42 regulates shell field morphogenesis in a gastropod mollusk.
Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats.
Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules.
A novel missense variant in HIKESHI: Clinical phenotype, in vitro functional testing, and potential for gene therapy.
Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis.
Astragaloside IV attenuates fatty acid-induced renal tubular injury in diabetic kidney disease by inhibiting fatty acid transport protein-2.
All-trans retinoic acid inhibits glioblastoma progression and attenuates radiation-induced brain injury.
TMEM232 is required for the formation of sperm flagellum and male fertility in mice.
YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma.
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.
Opposing roles for AMPK in regulating distinct mitophagy pathways.
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting.
TonEBP degradation is essential for microtubule nucleation and regrowth.
Proteomic profiling of gliomas unveils immune and metabolism-driven subtypes with implications for anti-nucleotide metabolism therapy.
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization.
NEDD4L contributes to ferroptosis and cell growth inhibition in esophageal squamous cell carcinoma by facilitating xCT ubiquitination.
An interaction network of inner centriole proteins organised by POC1A-POC1B heterodimer crosslinks ensures centriolar integrity.
Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis.
The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability.
The role of NLRP3 inflammasome-mediated neuroinflammation in chronic noise-induced impairment of learning and memory ability.
Upregulated DNMT3a coupling with inhibiting p62-dependent autophagy contributes to NNK tumorigenicity in human bronchial epithelial cells.
Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation.
OTUD6A orchestrates complex modulation of TEAD4-mediated transcriptional programs.
METTL16-mediated N6-methyladenosine modification of Soga1 enables proper chromosome segregation and chromosomal stability in colorectal cancer.
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.
Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1.
DMC-siERCC2 hybrid nanoparticle enhances TRAIL sensitivity by inducing cell cycle arrest for glioblastoma treatment.
Postprandial Triglyceride-Rich Lipoproteins-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Inflammation in White Adipocytes.
Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells.
Melatonin suppresses atherosclerosis by ferroptosis inhibition via activating NRF2 pathway.
Exercise activates interferon response of the liver via Gpld1 to enhance antiviral innate immunity.
A ZBP1 isoform blocks ZBP1-mediated cell death.
Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.
Melatonin Ameliorates Post-Stroke Cognitive Impairment in Mice by Inhibiting Excessive Mitophagy.
A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer disease.
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.
Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers.
An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins.
Cr(VI) induces ferroptosis in DF-1 cells by simultaneously perturbing iron homeostasis of ferritinophagy and mitophagy.
Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells.
Expanding the adenovirus toolbox: reporter viruses for studying the dynamics of human adenovirus replication.
Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma.
Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis.
Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity.
TH-4000, a hypoxia-activated pan-HER inhibitor, shows excellent preclinical efficacy for the treatment of HER2(+) breast cancer.
Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway.
Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways.
Novel compound heterozygous variants in FANCI cause premature ovarian insufficiency.
Dietary Restriction Improves Perioperative Neurocognitive Disorders by Inhibiting Neuroinflammation and Gut Microbial Dysbiosis.
Secretome from Magnetically Stimulated Muscle Exhibits Anticancer Potency: Novel Preconditioning Methodology Highlighting HTRA1 Action.
Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females.
Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes.
PELI1: key players in the oncogenic characteristics of pancreatic Cancer.
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
G-quadruplexes on chromosomal DNA negatively regulates topoisomerase 1 activity.
The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.
An alpha-herpesvirus employs host HEXIM1 to promote viral transcription.
CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response.
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.
DDX4 enhances antiviral activity of type I interferon by disrupting interaction of USP7/SOCS1 and promoting degradation of SOCS1.
Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion.
C-Myc/H19/miR-29b axis downregulates nerve/glial (NG)2 expression in glioblastoma multiforme.
Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo.
Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation.
TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response.
Ring finger protein 216 loss-of-function induces white matter hyperintensities by inhibiting oligodendroglia proliferation.
BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury.
Positron emission tomography guided synergistic treatment of melanoma using multifunctional zirconium-hematoporphyrin nanosonosensitizers.
Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
CGI1746 targets σ(1)R to modulate ferroptosis through mitochondria-associated membranes.
Integrated transcriptome and metabolome study reveal the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease.
SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.
Moracin D suppresses cell growth and induces apoptosis via targeting the XIAP/PARP1 axis in pancreatic cancer.
O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy.
Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice.
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Phosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma.
CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer.
IGF2BP2-Shox2 axis regulates hippocampal-neuronal senescence to alleviate microgravity-induced recognition disturbance.
Compositionally unique mitochondria in filopodia support cellular migration.
Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients.
EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease.
Peptide-encoding gene transfer to modulate intracellular protein-protein interactions.
Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.
COL8A1 is a potential prognostic biomarker associated with migration, proliferation, and tumor microenvironment in glioma.
Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer.
YBX1 as a prognostic biomarker and potential therapeutic target in hepatocellular carcinoma: A comprehensive investigation through bioinformatics analysis and in vitro study.
A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomes.
Spermatogenic cell-specific type 1 hexokinase (HK1S) is essential for capacitation-associated increase in tyrosine phosphorylation and male fertility in mice.
PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α.
Oridonin attenuates liver ischemia-reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis.
LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.
Engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer.
The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH.
SIL1 improves cognitive impairment in APP23/PS45 mice by regulating amyloid precursor protein processing and Aβ generation.
Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice.
Pan-cancer transcriptome analysis reveals widespread regulation through alternative tandem transcription initiation.
FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice.
Regulating effect of miR-132-3p on the changes of MAPK pathway in rat brains and SH-SY5Y cells exposed to excessive fluoride by targeting expression of MAPK1.
Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging.
Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.
Grape seed-derived procyanidin inhibits glyphosate-induced hepatocyte ferroptosis via enhancing crosstalk between Nrf2 and FGF12.
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Curcumin suppresses metastasis, invasion, and proliferation in osteosarcoma cells by regulating the EGFR/Src signaling axis.
Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics.
Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease.
Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations.
Integrating network pharmacology and bioinformatics to explore and experimentally verify the regulatory effect of Buyang Huanwu decoction on glycolysis and angiogenesis after cerebral infarction.
Porcine Intestinal Mucosal Peptides Target Macrophage-Modulated Inflammation and Alleviate Intestinal Homeostasis in Dextrose Sodium Sulfate-Induced Colitis in Mice.
2.7 Å cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
A nanobody inhibiting porcine reproductive and respiratory syndrome virus replication via blocking self-interaction of viral nucleocapsid protein.
The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping.
Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma.
Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.
siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells.
Macrophage-expressed SRA ameliorates alcohol-induced liver injury by suppressing S-glutathionylation of Notch1 via recruiting thioredoxin.
Identification of a basement membrane gene signature for predicting prognosis and estimating the tumor immune microenvironment in prostate cancer.
Cadmium exposure induces pyroptosis of TM4 cells through oxidative stress damage and inflammasome activation.
Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer.
Network pharmacology and transcriptomics to determine Danggui Yifei Decoction mechanism of action for the treatment of chronic lung injury.
S-Adenosylmethionine Inhibits the Proliferation of Retinoblastoma Cell Y79, Induces Apoptosis and Cell Cycle Arrest of Y79 Cells by Inhibiting the Wnt2/β-Catenin Pathway.
Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function.
Regulatory Effects and Mechanisms of L-Theanine on Neurotransmitters via Liver-Brain Axis Under a High Protein Diet.
The role and mechanism of RIPK1 in vascular endothelial dysfunction in chronic kidney disease.
Icariside II prevents kidney fibrosis development in chronic kidney disease by promoting fatty acid oxidation.
The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain.
Echinococcus granulosus cyst fluid inhibits the type I interferon response by promoting ROS in macrophages.
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.
RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination.
Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion.
N4-acetylcytidine modifies primary microRNAs for processing in cancer cells.
Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome.
Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization.
ALYREF-JunD-SLC7A5 axis promotes pancreatic ductal adenocarcinoma progression through epitranscriptome-metabolism reprogramming and immune evasion.
Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways.
Andrographolide derivative Andro-III modulates neuroinflammation and attenuates neuropathological changes of Alzheimer's disease via GSK-3β/NF-κB/CREB pathway.
ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
PTEN Mediates the Silencing of Unintegrated HIV-1 DNA.
Progesterone Receptor Membrane Component 1 Regulates Cellular Stress Responses and Inflammatory Pathways in Chronic Neuroinflammatory Conditions.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells.
Metabolites that feed upper glycolytic branches support glucose independent human cytomegalovirus replication.
Ferritin loss in astrocytes reduces spinal cord oxidative stress and demyelination in the experimental autoimmune encephalomyelitis (EAE) model.
Peroxynitrite-Triggered Carbon Monoxide Donor Improves Ischemic Stroke Outcome by Inhibiting Neuronal Apoptosis and Ferroptosis.
Pseudorabies virus UL13 primes inflammatory response through downregulating heat shock factor 1.
S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway.
Bag2 protects against doxorubicin-induced cardiotoxicity by maintaining Pink1-mediated mitophagy.
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.
BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells.
Glutamine sensing licenses cholesterol synthesis.
ZFP36 Facilitates Senecavirus A (SVA) replication by inhibiting the production of type I interferon.
The deficiency of ALKBH5 contributes to hepatic lipid deposition by impairing VPS11-dependent autophagic flux.
Knockdown of nicotinamide N-methyltransferase ameliorates renal fibrosis caused by ischemia-reperfusion injury and remodels sphingosine metabolism.
Protective effect of lycorine hydrochloride against diabetic nephropathy in high-fat diet and streptozotocin-induced diabetic mice.
METTL14 is Involved in TNF-α-Induced Inflammation in Colorectal Epithelial Cells via Autophagy Modulation.
TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer cell proliferation through the c-Myc/p21 axis.
Discovery of epigenetic modulators targeting HDACs and EZH2 simultaneously for the treatment of hematological malignancies.
The deubiquitinase OTUB1 inhibits gluconeogenesis by stabilizing YWHAB.
Targeting BRIX1 via Engineered Exosomes Induces Nucleolar Stress to Suppress Cancer Progression.
CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer.
Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates.
Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition.
SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia.
Inhibition of protein kinase D and its substrate phosphatidylinositol-4 kinase III beta blocks common human coronavirus replication.
S-adenosylmethionine and S-adenosyl-L-homocysteine metabolism is involved in the sperm motility and in vitro fertility rate in mouse.
Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study.
Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA.
Macrophage NLRP3-dependent IL-1β production contributes to aortic fibrosis in heart failure with preserved ejection fraction.
Ancestry-linked stromal variations impact breast epithelial cell invasion.
MS4A3 regulates hematopoietic myeloid differentiation through ROS/TGF-β/p38MAPK pathway.
Restoration of RECK expression attenuates liver fibrosis induced by carbon tetrachloride through the Nrf2-MMP9 axis.
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis.
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
C5aR1-positive adipocytes mediate non-shivering thermogenesis in neonatal mice.
SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.
Migratory autolysosome disposal mitigates lysosome damage.
ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis.
Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma.
Eltrombopag restores proliferative capacity and adipose-osteogenic balance of mesenchymal stromal cells in low-risk myelodysplastic syndromes.
Discovery of sp(3)-rich diazatricycloundecanes as lysosomotropic autophagy inhibitors.
Phospho-regulation of ASCL1-mediated chromatin opening during cellular reprogramming.
Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system.
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis.
GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma.
GPR124 promotes trophoblast proliferation, migration, and invasion and inhibits trophoblast cell apoptosis and inflammation via JNK and P38 MAPK pathways.
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma.
Assembly mechanism of Integrator's RNA cleavage module.
Development of Preladenant-Based Radiotracers for Imaging A(2A)R in Tumors.
EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells.
RILP Induces Cholesterol Accumulation in Lysosomes by Inhibiting Endoplasmic Reticulum-Endolysosome Interactions.
40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice.
DAPK1 mediates cognitive dysfunction and neuronal apoptosis in PSD rats through the ERK/CREB/BDNF signaling pathway.
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation.
CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator.
Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte.
Healthy Plasma Exosomes Exert Potential Neuroprotective Effects against Methylmalonic Acid-Induced Hippocampal Neuron Injury.
FXN targeting induces cell death in ovarian cancer stem-like cells through PRDX3-Mediated oxidative stress.
Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality.
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation.
FYN-mediated phosphorylation of BCKDK at Y151 promotes GBM proliferation by increasing the oncogenic metabolite N-acetyl-L-alanine.
Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation.
Capsaicin enhances cisplatin-induced anti-metastasis of nasopharyngeal carcinoma by inhibiting EMT and ERK signaling via serpin family B member 2.
Membranous translocation of murine double minute 2 promotes the increased renal tubular immunogenicity in ischemia-reperfusion-induced acute kidney injury.
Single-Cell RNA Sequencing Identifies WARS1+ Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Improved Therapeutic Efficacy.
Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer.
Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation.
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency.
Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex.
Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.
Pyrazole derivative Z10 ameliorates acute pancreatitis by inhibiting the ERK/Ddt pathway.
Trilobatin attenuates cerebral ischaemia/reperfusion-induced blood-brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive.
The role of Map1b in regulating osteoblast polarity, proliferation, differentiation and migration.
Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain.
Amplified and Specific Staining of Protein Dimerization on Cell Membrane Catalyzed by Responsively Installed DNA Nanomachines for Cancer Diagnosis.
Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys.
Identification of CERS5 as a molecular biomarker in pan-cancer through multiple omics integrative analysis.
Nanoparticle Targeting in Chemo-Resistant Ovarian Cancer Reveals Dual Axis of Therapeutic Vulnerability Involving Cholesterol Uptake and Cell Redox Balance.
Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma.
Genetic interactions reveal distinct biological and therapeutic implications in breast cancer.
BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling.
m(1)A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma.
Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy.
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores.
KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity.
PRMT4 interacts with NCOA4 to inhibit ferritinophagy in cisplatin-induced acute kidney injury.
GTPBP8 modulates mitochondrial fission through a Drp1-dependent process.
Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy.
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.
Tepsin binds LC3B to promote ATG9A trafficking and delivery.
PCP4 Promotes Alzheimer's Disease Pathogenesis by Affecting Amyloid-β Protein Precursor Processing.
Platelet-Derived Mitochondria Attenuate 5-FU-Induced Injury to Bone-Associated Mesenchymal Stem Cells.
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Comprehensive Analysis of Sideroflexin 4 in Hepatocellular Carcinoma by Bioinformatics and Experiments.
Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation.
Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis.
Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice.
Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor.
Transplantation of Human Amniotic Mesenchymal Stem Cells Up-Regulates Angiogenic Factor Expression to Attenuate Diabetic Kidney Disease in Rats.
Expression and Clinical Significance of TIGIT in Primary Breast Cancer.
Gongying-Jiedu-Xiji recipe promotes the healing of venous ulcers by inhibiting ferroptosis via the CoQ-FSP1 axis.
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.
GNPNAT1 is a potential biomarker correlated with immune infiltration and immunotherapy outcome in breast cancer.
ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes.
Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Inhibition of Na+/H+ exchanger (NHE) 7 by 5-(N-ethyl-N-isopropyl)-Amiloride displays anti-cancer activity in non-small cell lung cancer by disrupting cancer stem cell activity and downregulating PD-L1 expression.
EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO.
Hypoxanthine guanine phosphoribosyltransferase 1, a target of miR-125b-5p, promotes cell proliferation and invasion in head and neck squamous cell carcinoma.
Functional Characterization of MC4R Variants in Chinese Morbid Obese Patients and Weight Loss after Bariatric Surgery.
Dietary Eicosapentaenoic Acid Containing Phosphoethanolamine Plasmalogens Remodels the Lipidome of White Adipose Tissue and Suppresses High-Fat Diet Induced Obesity in Mice.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells.
RBMX involves in telomere stability maintenance by regulating TERRA expression.
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
Centrosome linker diversity and its function in centrosome clustering and mitotic spindle formation.
Increased DNMT1 Involvement in the Activation of LO2 Cell Death Induced by Silver Nanoparticles via Promoting TFEB-Dependent Autophagy.
Baicalin Attenuates Panton-Valentine Leukocidin (PVL)-Induced Cytoskeleton Rearrangement via Regulating the RhoA/ROCK/LIMK and PI3K/AKT/GSK-3β Pathways in Bovine Mammary Epithelial Cells.
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics.
Perillaldehyde Mitigates Ionizing Radiation-Induced Intestinal Injury by Inhibiting Ferroptosis via the Nrf2 Signaling Pathway.
Effect of eIF2α in Neuronal Injury Induced by High Glucose and the Protective Mechanism of Resveratrol.
Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1.
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer.
RNA-binding protein-regulated fibronectin is essential for EGFR-activated metastasis of head and neck squamous cell carcinoma.
Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.
Niclosamide inhibits TGF-β1-induced fibrosis of human Tenon's fibroblasts by regulating the MAPK-ERK1/2 pathway.
Unveiling potentially convergent key events related to adverse outcome pathways induced by silver nanoparticles via cross-species omics-scale analysis.
Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease.
DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation.
Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes.
15-keto-PGE(2) alleviates nonalcoholic steatohepatitis through its covalent modification of NF-κB factors.
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions.
Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation.
Phase separation underlies signaling activation of oncogenic NTRK fusions.
RAP80 phase separation at DNA double-strand break promotes BRCA1 recruitment.
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer.
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.
Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling.
D-mannose induces TFE3-dependent lysosomal degradation of EGFR and inhibits the progression of NSCLC.
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
"Affimer" synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation.
Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice.
Hypomethylation of DRD2 promotes breast cancer through the FLNA-ERK pathway.
The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury.
A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3.
PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway.
Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance.
p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP.
Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer.
Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.
Nuclear-cytoplasmic asynchrony in oocyte maturation caused by TUBB8 variants via impairing microtubule function: a novel pathogenic mechanism.
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity.
Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma.
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51.
Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis.
Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis.
Asparagine endopeptidase protects podocytes in adriamycin-induced nephropathy by regulating actin dynamics through cleaving transgelin.
Tumor necrosis factor-α-induced protein 8-like 2 alleviates morphine antinociceptive tolerance through reduction of ROS-mediated apoptosis and MAPK/NF-κB signaling pathways.
Genome-Wide CRISPR/Cas9 Screening Identifies That Mitochondrial Solute Carrier SLC25A23 Attenuates Type I IFN Antiviral Immunity via Interfering with MAVS Aggregation.
TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination.
Prognostic role and immune infiltration characteristics of EI24 in multiple cancer types.
Prophylaxis of posterior capsule opacification through autophagy activation with indomethacin-eluting intraocular lens.
Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion.
Fecal microbiota transplantation ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota in db/db mice.
Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis.
Repurposing crizotinib to target RIPK1-dependent cell death.
Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis.
Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus.
Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy.
Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry.
Specific Residues in the C-Terminal Domain of the Human Metapneumovirus Phosphoprotein Are Indispensable for Formation of Viral Replication Centers and Regulation of the Function of the Viral Polymerase Complex.
SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A.
Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart.
SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma.
FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth.
Transferrin Receptor Is Necessary for Proper Oligodendrocyte Iron Homeostasis and Development.
The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.
Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
Ubiquitin E3 ligase β-TrCP negatively regulates surface protein of hepatitis B virus.
Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation.
QSER1 preserves the suppressive status of the pro-apoptotic genes to prevent apoptosis.
Ginsenoside Rg1 regulates thiram-induced chondrocytes' apoptosis and angiogenesis in broiler chickens.
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression.
The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.
Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.
The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease.
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
RIG-I Promotes Tumorigenesis and Confers Radioresistance of Esophageal Squamous Cell Carcinoma by Regulating DUSP6.
Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates.
P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.
Glyphosate-triggered hepatocyte ferroptosis via suppressing Nrf2/GSH/GPX4 axis exacerbates hepatotoxicity.
RNA localization to the mitotic spindle is essential for early development and is regulated by kinesin-1 and dynein.
Kawasaki disease: ubiquitin-specific protease 5 promotes endothelial inflammation via TNFα-mediated signaling.
IL-17C neutralization protects the kidney against acute injury and chronic injury.
Structural basis for FGF hormone signalling.
Magnify is a universal molecular anchoring strategy for expansion microscopy.
Rab26 restricts insulin secretion via sequestering Synaptotagmin-1.
Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK.
GLUT4 degradation by GLUTFOURINH® in mice resembles moderate-obese diabetes of human with hyperglycemia and low lipid accumulation.
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion.
Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway.
Cycloheximide (CHX) Chase Assay to Examine Protein Half-life.
Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure.
TFF3 promotes clonogenic survival of colorectal cancer cells through upregulation of EP4 via activation of STAT3.
A Potential Anti-Glioblastoma Compound LH20 Induces Apoptosis and Arrest of Human Glioblastoma Cells via CDK4/6 Inhibition.
GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail.
The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection.
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8.
Long noncoding RNA HITT coordinates with RGS2 to inhibit PD-L1 translation in T cell immunity.
NLRP3 inflammasome inhibition of OP9 cells enhance therapy for inflammatory bowel disease.
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Nucleolar protein treacle ribosome biogenesis factor 1 maintains gastric cancer cell proliferation by regulating R-loop associated DNA replication stress.
COLEC10 Induces Endoplasmic Reticulum Stress by Occupying GRP78 and Inhibits Hepatocellular Carcinoma.
Protopine Alleviates Dextran Sodium Sulfate-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Regulating Intestinal Microbiota.
Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.
Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-κB/MGMT Axis.
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.
The NF-Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer.
Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis.
Ethyl acetate extract of Antenoron Filiforme inhibits the proliferation of triple negative breast cancer cells via suppressing Skp2/p21 signaling axis.
Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery.
Design, Synthesis and Biological Evaluation of Histone Deacetylase Inhibitors Based on Pyrrolo[2,3-d]pyrimidine and Pyrrolo[2,3-b]pyridine Scaffolds.
KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy.
VASN promotes colorectal cancer progression by activating the YAP/TAZ and AKT signaling pathways via YAP.
Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
Methotrexate and Triptolide regulate Notch signaling pathway by targeting the Nedd4-Numb axis.
Ivacaftor-Mediated Potentiation of ABCB4 Missense Mutations Affecting Critical Motifs of the NBDs: Repositioning Perspectives for Hepatobiliary Diseases.
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability.
Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease.
SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2.
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth.
[WITHDRAWN] Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction.
AmAtg2B-Mediated Lipophagy Regulates Lipolysis of Pupae in Apis mellifera.
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway.
STAT3/Mitophagy Axis Coordinates Macrophage NLRP3 Inflammasome Activation and Inflammatory Bone Loss.
Effects of ferroptosis in myocardial ischemia/reperfusion model of rat and its association with Sestrin 1.
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers.
Mitochondria-localized lncRNA HITT inhibits fusion by attenuating formation of mitofusin-2 homotypic or heterotypic complexes.
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma.
Effects of different remote ischemia perconditioning methods on cerebral infarct volume and neurological impairment in rats.
Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1-CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice.
Novel ELAC2 Mutations in Individuals Presenting with Variably Severe Neurological Disease in the Presence or Absence of Cardiomyopathy.
PGRMC1 Ablation Protects from Energy-Starved Heart Failure by Promoting Fatty Acid/Pyruvate Oxidation.
LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei.
Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.
ERRα Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis.
Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis.
Repositioning linifanib as a potent anti-necroptosis agent for sepsis.
Stimulation of functional recovery via neurorepair mechanisms by the traditional Japanese Kampo medicine, Ninjin'yoeito, and physical exercise in a rat ischemic stroke model.
Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation.
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism.
Ame-miR-980-3p participates in autophagy-mediated midgut remodelling in Apis mellifera via targeting Atg2B.
CDC20 promotes radioresistance of prostate cancer by activating Twist1 expression.
High cholesterol diet-induced testicular dysfunction in rats.
DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells.
Ceftazidime reduces cellular Skp2 to promote type-I interferon activity.
Identification of basement membrane markers in diabetic kidney disease and immune infiltration by using bioinformatics analysis and experimental verification.
Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis.
Hydroxypropyl-β-cyclodextrin inhibits the development of triple negative breast cancer by enhancing antitumor immunity.
Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
Identification of nonfunctional PABPC1L causing oocyte maturation abnormalities and early embryonic arrest in female primary infertility.
Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.
CX43 down-regulation promotes cell aggressiveness and 5-fluorouracil-resistance by attenuating cell stiffness in colorectal carcinoma.
Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation.
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration.
FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation.
The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis.
FGIN-1-27 Mitigates Radiation-induced Mitochondrial Hyperfunction and Cellular Hyperactivation in Cultured Astrocytes.
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing.
Combined Aurora Kinase A and CHK1 Inhibition Enhances Radiosensitivity of Triple-Negative Breast Cancer Through Induction of Apoptosis and Mitotic Catastrophe Associated With Excessive DNA Damage.
The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation.
Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress.
Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma.
Restoration of energy homeostasis under oxidative stress: Duo synergistic AMPK pathways regulating arginine kinases.
Dppa3 Improves the Germline Competence of Pluripotent Stem Cells.
Identification and validation of Birc5 as a novel activated cell cycle program biomarker associated with infiltration of immunosuppressive myeloid-derived suppressor cells in hepatocellular carcinoma.
A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma.
Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells-derived neural rosettes.
ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.
UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks.
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Tissue pleiotropic effect of biotin and prebiotic supplementation in established obesity.
Homotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics.
Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.
Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8(+) T cell exhaustion via TRIM14-IFN-β axis.
Subcellular localization shapes the fate of RNA polymerase III.
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.
Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression.
The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters.
SOSSB1 and SOSSB2 mutually regulate protein stability through competitive binding of SOSSA.
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling.
Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway.
Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1.
Muscleblind-like 2 knockout shifts adducin 1 isoform expression and alters dendritic spine dynamics of cortical neurons during brain development.
C4orf19 inhibits colorectal cancer cell proliferation by competitively binding to Keap1 with TRIM25 via the USP17/Elk-1/CDK6 axis.
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
MiR-216a-3p inhibits the proliferation and invasion of fibroblast-like synoviocytes by targeting dual-specificity phosphatase 5.
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Knockdown of KDM5B Leads to DNA Damage and Cell Cycle Arrest in Granulosa Cells via MTF1.
Vitamin C promotes ACE2 degradation and protects against SARS-CoV-2 infection.
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.
Vitamin D3 and Lactobacillus rhamnosus GG/p40 Synergize to Protect Mice From Colitis by Promoting Vitamin D Receptor Expression and Epithelial Proliferation.
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy.
TRAF6 Promotes PRMT5 Activity in a Ubiquitination-Dependent Manner.
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis.
RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits.
Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.
Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction.
Solamargine Alleviated UVB-Induced Inflammation and Melanogenesis in Human Keratinocytes and Melanocytes via the p38 MAPK Signaling Pathway, a Promising Agent for Post-inflammatory Hyperpigmentation.
lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization.
Resveratrol Synergistically Promotes BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells.
STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages.
Catalpol Regulates Oligodendrocyte Regeneration and Remyelination by Activating the GEF-Cdc42/Rac1 Signaling Pathway in EAE Mice.
Peripheral Transplantation of Mesenchymal Stem Cells at Sepsis Convalescence Improves Cognitive Function of Sepsis Surviving Mice.
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Conditional deletion of MAD2B in forebrain neurons enhances hippocampus-dependent learning and memory in mice.
Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson's Disease.
Healthy Serum-Derived Exosomes Improve Neurological Outcomes and Protect Blood-Brain Barrier by Inhibiting Endothelial Cell Apoptosis and Reversing Autophagy-Mediated Tight Junction Protein Reduction in Rat Stroke Model.
LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis.
Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
SIX1 Predicts Poor Prognosis and Facilitates the Progression of Non-small Lung Cancer via Activating the Notch Signaling Pathway.
Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.
Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent manner.
Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine.
Effect of Platycodon grandiflorus Polysaccharide on M1 Polarization Induced by Autophagy Degradation of SOCS1/2 Proteins in 3D4/21 Cells.
Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.
Genome-Wide Analysis of the Indispensable Role of Non-structural Proteins in the Replication of SARS-CoV-2.
Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes.
Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.
TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.
Worenine Prevents Solar Ultraviolet-Induced Sunburn by Inhibiting JNK2.
Identification and Characterization of BmNPV m6A Sites and Their Possible Roles During Viral Infection.
BmCPV-Derived Circular DNA vcDNA-S7 Mediated by Bombyx mori Reverse Transcriptase (RT) Regulates BmCPV Infection.
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
N-Acetyldopamine Dimer Attenuates DSS-Induced Ulcerative Colitis by Suppressing NF-κB and MAPK Pathways.
Induction of Collagen I by CXCL10 in Ovarian Theca-Stroma Cells via the JNK Pathway.
TRIM67 Suppresses TNFalpha-Triggered NF-kB Activation by Competitively Binding Beta-TrCP to IkBa.
The involvement of the primo vascular system in local enteritis and its modification by electroacupuncture.
Protective effects of mefunidone on ischemia-reperfusion injury/Folic acid-induced acute kidney injury.
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice.
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation.
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
N(6)-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming.
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma.
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Olaparib Induces RPL5/RPL11-Dependent p53 Activation via Nucleolar Stress.
The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma.
Maternal Factor Dppa3 Activates 2C-Like Genes and Depresses DNA Methylation in Mouse Embryonic Stem Cells.
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination.
Transmembrane protein 121 as a novel inhibitor of cervical cancer metastasis.
Acetylation of fructose-bisphosphate aldolase-mediated glycolysis is essential for Bombyx mori nucleopolyhedrovirus infection.
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis.
TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway.
Multiple ciliary localization signals control INPP5E ciliary targeting.
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Construction of Artificial Ovaries with Decellularized Porcine Scaffold and Its Elicited Immune Response after Xenotransplantation in Mice.
Inhibiting ALK-TOPK signaling pathway promotes cell apoptosis of ALK-positive NSCLC.
Analysis of the Effects of Ninjin'yoeito on Physical Frailty in Mice.
Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer.
In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators.
PBAF chromatin remodeler complexes that mediate meiotic transitions in mouse.
Seneca Valley Virus Induces DHX30 Cleavage to Antagonize Its Antiviral Effects.
An acetylated mannan isolated from Aloe vera induce colorectal cancer cells apoptosis via mitochondrial pathway.
Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication.
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.
Human Cytomegalovirus UL24 and UL43 Cooperate to Modulate the Expression of Immunoregulatory UL16 Binding Protein 1.
Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis.
Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription.
Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function.
DNA methylation status of DNAJA4 is essential for human erythropoiesis.
A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma.
Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation.
D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia.
The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes.
Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12.
Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity.
STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment.
PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK.
Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model.
Hypotonic induction of aquaporin5 expression in rat astrocytes through p38 MAPK pathway.
E3 ubiquitin ligase MID1 ubiquitinates and degrades type-I interferon receptor 2.
HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
Menthone inhibits type-I interferon signaling by promoting Tyk2 ubiquitination to relieve local inflammation of rheumatoid arthritis.
UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum.
Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export.
Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice.
BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
Naringenin Promotes Myotube Formation and Maturation for Cultured Meat Production.
Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.
Integrative and Comprehensive Pan-Cancer Analysis of Lymphocyte-Specific Protein Tyrosine Kinase in Human Tumors.
METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability.
KIF17 maintains the epithelial phenotype of breast cancer cells and curbs tumour metastasis.
Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation.
D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes.
Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics.
MEIG1 determines the manchette localization of IFT20 and IFT88, two intraflagellar transport components in male germ cells.
A comparative study of Mesenchymal Stem Cells transplantation approach to antagonize age-associated ovarian hypofunction with consideration of safety and efficiency.
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair.
Deletion of the miR-144/451 cluster aggravates lethal sepsis-induced lung epithelial oxidative stress and apoptosis.
A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus.
Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma.
Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.
Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment.
MRNIP condensates promote DNA double-strand break sensing and end resection.
Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.
Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia.
miR-1290 promotes IL-8-mediated vascular endothelial cell adhesion by targeting GSK-3β.
iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.
Map, but not EspF, induces breast epithelial cell apoptosis through ERK/DRP-1 pathway.
LINC00244 suppresses cell growth and metastasis in hepatocellular carcinoma by downregulating programmed cell death ligand 1.
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells.
Neddylation is essential for β-catenin degradation in Wnt signaling pathway.
The identification of alternative oxidase in intermediate host snails of Schistosoma and its potential role in protecting Oncomelania hupensis against niclosamide-induced stress.
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
RAD51 is essential for spermatogenesis and male fertility in mice.
C3/C3aR inhibition alleviates GMH-IVH-induced hydrocephalus by preventing microglia-astrocyte interactions in neonatal rats.
ARID3A promotes the chemosensitivity of colon cancer by inhibiting AKR1C3.
MiR-15p-5p Mediates the Coordination of ICAM-1 and FAK to Promote Endothelial Cell Proliferation and Migration.
Resveratrol alleviates aluminum-induced intestinal barrier dysfunction in mice.
Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
Cell cycle arrest induced by trichoplein depletion is independent of cilia assembly.
Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer.
Insulin alleviates LPS-induced ARDS via inhibiting CUL4B-mediated proteasomal degradation and restoring expression level of Na,K-ATPase α1 subunit through elevating HCF-1.
MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1).
Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism.
Enhanced autophagy promotes radiosensitivity by mediating Sirt1 downregulation in RM-1 prostate cancer cells.
Protocol for isolation and proteostatic analysis of sub-populations of spermatogenic cells in mouse.
Isolation of five different primary cell types from a single sample of human skin.
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding.
H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis.
Antagonistic action of a synthetic androgen ligand mediated by chromatin remodeling in a human prostate cancer cell line.
Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1.
Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling.
ER proteins decipher the tubulin code to regulate organelle distribution.
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease.
Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress.
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites.
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence.
Annexin A1 promotes the progression of bladder cancer via regulating EGFR signaling pathway.
High salt activates p97 to reduce host antiviral immunity by restricting Viperin induction.
DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway.
Inhibiting STAT5 significantly attenuated Ang II-induced cardiac dysfunction and inflammation.
Aging is associated with increased brain iron through cortex-derived hepcidin expression.
Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
Ajuba functions as a co-activator of C/EBPβ to induce expression of PPARγ and C/EBPα during adipogenesis.
Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.
Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4.
4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects.
Alpha-synuclein/MPP(+) mediated activation of NLRP3 inflammasome through microtubule-driven mitochondrial perinuclear transport.
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1.
HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.
Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription.
Progerin-expressing endothelial cells are unable to adapt to shear stress.
ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation.
Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly.
HIF-1α upregulation exerts the antagonistic effect against angiogenesis inhibition in manganese deficiency-induced tibial dyschondroplasia of broiler chicks.
6-O-desulfated heparin attenuates myocardial ischemia/reperfusion injury in mice through the regulation of miR-199a-5p/klotho axis.
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.
The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-κB pathway and activating Keap1-NRF2 signaling in macrophages.
Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway.
Mefunidone ameliorates lipopolysaccharide-induced acute lung injury through inhibiting MAPK signaling pathway and enhancing Nrf2 pathway.
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner.
Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair.
The central scaffold protein CEP350 coordinates centriole length, stability, and maturation.
Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway.
Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence.
The deubiquitinase USP10 protects pancreatic cancer cells from endoplasmic reticulum stress.
Trehalose prevents glyphosate-induced testicular damage in roosters via its antioxidative properties.
Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis.
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway.
Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma.
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Metformin alleviates the cognitive impairment caused by aluminum by improving energy metabolism disorders in mice.
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1.
Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.
The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy.
Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers.
Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes.
Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma.
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0.
Damage of uremic myocardium by p-cresyl sulfate and the ameliorative effect of Klotho by regulating SIRT6 ubiquitination.
A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology.
Recycling of autophagosomal components from autolysosomes by the recycler complex.
Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation.
LATS1 is a central signal transmitter for achieving full type-I interferon activity.
Hexokinase 1 cellular localization regulates the metabolic fate of glucose.
DELE1 tracks perturbed protein import and processing in human mitochondria.
Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression.
Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXRα/PCSK9 pathway.
Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors.
Inhibition of CK2 Reduces NG2 Expression in Juvenile Angiofibroma.
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
Secondary structure RNA elements control the cleavage activity of DICER.
Osteopontin is required for the maintenance of leukemia stem cells in acute myeloid leukemia.
ILF3 represses repeat-derived microRNAs targeting RIG-I mediated type I interferon response.
Brown adipose tissue involution associated with progressive restriction in progenitor competence.
Long noncoding RNA SH3PXD2A-AS1 promotes NSCLC proliferation and accelerates cell cycle progression by interacting with DHX9.
Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation.
SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer.
BRCC36 prevents vascular calcification in chronic kidney disease through the β-catenin signalling pathway.
Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.
Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy.
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
Impaired Retrograde Transport Due to Lack of TBC1D5 Contributes to the Trafficking Defect of Lysosomal Cathepsins in Ischemic/Hypoxic Cardiomyocytes.
Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.
PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca(2+)/Calpain/VE-Cadherin Signaling.
FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.
Sirt3 Maintains Microvascular Endothelial Adherens Junction Integrity to Alleviate Sepsis-Induced Lung Inflammation by Modulating the Interaction of VE-Cadherin and β-Catenin.
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
NR1D1 Deletion Induces Rupture-Prone Vulnerable Plaques by Regulating Macrophage Pyroptosis via the NF-κB/NLRP3 Inflammasome Pathway.
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Chirality and asymmetry increase the potency of candidate ADRM1/RPN13 inhibitors.
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
N6-methyladenosine regulates ATM expression and downstream signaling.
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Small Molecule Palmatine Targeting Musashi-2 in Colorectal Cancer.
Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway.
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Melatonin Alleviates Renal Injury in Mouse Model of Sepsis.
Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands.
Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development.
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation.
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis.
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer.
Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma.
SLC25A21 Suppresses Cell Growth in Bladder Cancer via an Oxidative Stress-Mediated Mechanism.
ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats.
OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.
CUL4(high) Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.
PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons.
Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway.
Down-regulation of Polo-like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer.
Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1.
Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells.
Androgen-dependent and DNA-binding-independent association of androgen receptor with chromatic regions coding androgen-induced noncoding RNAs.
Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers.
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Hypoxia regulates overall mRNA homeostasis by inducing Met(1)-linked linear ubiquitination of AGO2 in cancer cells.
Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.
Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovarian cancer cells.
Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure.
HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages.
Loss of E-cadherin due to road dust PM(2.5) activates the EGFR in human pharyngeal epithelial cells.
Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells.
ORMDL1 is upregulated and associated with favorable outcomes in colorectal cancer.
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium.
The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle.
Preconditioning Exercise in Rats Attenuates Early Brain Injury Resulting from Subarachnoid Hemorrhage by Reducing Oxidative Stress, Inflammation, and Neuronal Apoptosis.
Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress.
Cycloastragenol and Astragaloside IV activate telomerase and protect nucleus pulposus cells against high glucose-induced senescence and apoptosis.
Selective autophagy receptor SQSTM1/ p62 inhibits Seneca Valley virus replication by targeting viral VP1 and VP3.
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
Caspase-3/NLRP3 signaling in the mesenchymal stromal niche regulates myeloid-biased hematopoiesis.
Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients.
Screening and identification of autophagy-related biomarkers for oral squamous cell carcinoma (OSCC) via integrated bioinformatics analysis.
BCL7C suppresses ovarian cancer growth by inactivating mutant p53.
Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes.
One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver.
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA.
Effect of low-intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer's disease.
TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication.
NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions.
lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1.
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.
Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.
Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants.
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.
RAB10 Interacts with ABCB4 and Regulates Its Intracellular Traffic.
Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.
The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells.
Nuclear Lamin A/C Expression Is a Key Determinant of Paclitaxel Sensitivity.
Nitrogen-Doped Multiwalled Carbon Nanotubes Enhance Bone Remodeling through Immunomodulatory Functions.
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway.
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome.
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
HSV-1-encoded ICP0 degrades the host deubiquitinase BRCC36 to antagonize interferon antiviral response.
Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3.
Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB.
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.
Antibody Self-Assembly Maximizes Cytoplasmic Immunostaining Accuracy of Compact Quantum Dots.
Seneca Valley Virus 3C Protease Induces Pyroptosis by Directly Cleaving Porcine Gasdermin D.
Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway.
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.
The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors.
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
ATG5 is instrumental in the transition from autophagy to apoptosis during the degeneration of tick salivary glands.
Identification of fusarielin M as a novel inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB).
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation.
Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases.
Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150(glued).
In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma.
Enterovirus D68 Protease 2A(pro) Targets TRAF3 To Subvert Host Innate Immune Responses.
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer.
Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells.
BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability.
Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense.
Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death.
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
A newly identified small molecular compound acts as a protein kinase inhibitor to suppress metastasis of colorectal cancer.
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.
p53 induces ARTS to promote mitochondrial apoptosis.
Discovery of a novel AR/HDAC6 dual inhibitor for prostate cancer treatment.
Ginsenoside Rb1 protected PC12 cells from Aβ(25-35)-induced cytotoxicity via PPARγ activation and cholesterol reduction.
Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development.
LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.
Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication.
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors.
UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
CircSTK40 contributes to recurrent implantation failure via modulating the HSP90/AKT/FOXO1 axis.
Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANA(SIM)-Associated Proteins in Hypoxia.
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions.
Regulation of PDGFR-β gene expression by targeting the G-vacancy bearing G-quadruplex in promoter.
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
Cadmium exposure induces osteoporosis through cellular senescence, associated with activation of NF-κB pathway and mitochondrial dysfunction.
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Proteomic analysis of the exosomes secreted from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus reveals their involvement in the cellular responses to viral infection.
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation.
Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1.
Identification of the Bcl-2 and Bax homologs from Rhipicephalus haemaphysaloides and their function in the degeneration of tick salivary glands.
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.
Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy.
Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression.
Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9(+) cells to prevent the development of liver cancer in a mouse model.
MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.
Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.
Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.
Oxytocin Alleviates MPTP-Induced Neurotoxicity in Mice by Targeting MicroRNA-26a/Death-Associated Protein Kinase 1 Pathway.
β-Actin facilitates etoposide-induced p53 nuclear import.
Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway.
Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.
Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function.
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction.
Berberine Induces CYP2J2 Expression in Human U251 Glioma Cells via Regulation of Peroxisome Proliferator-Activated Receptor Alpha.
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
ITM2A as a Tumor Suppressor and Its Correlation With PD-L1 in Breast Cancer.
NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer.
A role of cellular translation regulation associated with toxic Huntingtin protein.
The protective effect of rosmarinic acid on myotube formation during myoblast differentiation under heat stress.
Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells.
SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells.
Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling.
A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1.
LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells.
PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase.
Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner.
RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.
MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency.
Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Nuclear import of NLS- RARα is mediated by importin α/β.
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.
Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib.
Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress.
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape.
A novel mutation in GPD1‑L associated with early repolarization syndrome via modulation of cardiomyocyte fast sodium currents.
Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.
A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.
FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells.
Development of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells.
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation.
Structural basis for DEAH-helicase activation by G-patch proteins.
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Generation and Application of Mouse Monoclonal Antibody Against Human Cytomegalovirus UL23.
ChREBP-β regulates thermogenesis in brown adipose tissue.
FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression.
Initiator and executioner caspases in salivary gland apoptosis of Rhipicephalus haemaphysaloides.
RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling.
M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT.
SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response.
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation In Vivo.
Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.
Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation.
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.
Inhibition of the ATR-CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2.
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion.
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.
High-brightness anterograde transneuronal HSV1 H129 tracer modified using a Trojan horse-like strategy.
A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia.
Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway.
Ibrutinib Potentiates Antihepatocarcinogenic Efficacy of Sorafenib by Targeting EGFR in Tumor Cells and BTK in Immune Cells in the Stroma.
Murine Cytomegalovirus Protein pM49 Interacts with pM95 and Is Critical for Viral Late Gene Expression.
Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.
Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1.
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity.
lncMGPF is a novel positive regulator of muscle growth and regeneration.
GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation.
DNA damage in human glomerular endothelial cells induces nodular glomerulosclerosis via an ATR and ANXA2 pathway.
USP39 Serves as a Deubiquitinase to Stabilize STAT1 and Sustains Type I IFN-Induced Antiviral Immunity.
Downregulation of miR-146b-5p via iodine involvement repressed papillary thyroid carcinoma cell proliferation.
Dual-engineered, "Trojanized" macrophages bio-modally eradicate tumors through biologically and photothermally deconstructing cancer cells in an on-demand, NIR-commanded, self-explosive manner.
ZMIZ1 promotes the proliferation and migration of melanocytes in vitiligo.
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD.
GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Targeting PML in triple negative breast cancer elicits growth suppression and senescence.
Effects of peptidoglycan on the development of steatohepatitis.
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110.
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells.
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis.
The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression.
Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos.
CACYBP Enhances Cytoplasmic Retention of P27(Kip1) to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.
The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma.
Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal Rats.
Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome.
Phosphorylation of Microtubule- Associated Protein 4 Promotes Hypoxic Endothelial Cell Migration and Proliferation.
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.
Seneca Valley virus 2C and 3C inhibit type I interferon production by inducing the degradation of RIG-I.
Preparation and identification of polyclonal antibody against human cytomegalovirus encoding protein UL23.
Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.
Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1.
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes.
Vacuolar protein sorting 4 is required for silkworm metamorphosis.
Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage.
Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.
Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein.
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.
PARP11 regulates total levels of type-I interferon receptor IFNAR1.
Genomic Structure of Hstx2 Modifier of Prdm9-Dependent Hybrid Male Sterility in Mice.
Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma.
ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade.
DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella.
Glutamate affects the CYP1B1- and CYP2U1-mediated hydroxylation of arachidonic acid metabolism via astrocytic mGlu5 receptor.
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
p53 suppression is essential for oncogenic SPAG5 upregulation in lung adenocarcinoma.
Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication.
Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.
Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis.
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
Embryonic morphology observation and HOXC8 gene expression in crest cushions of Chinese Crested duck.
Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.
Chromosome misalignment is associated with PLK1 activity at cenexin-positive mitotic centrosomes.
Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.
Tranilast enhances the effect of anticancer agents in osteosarcoma.
WD40 repeat and FYVE domain containing 3 is essential for cardiac development.
Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis.
m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury.
Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.
Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis.
Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.
Dissecting the Role of DDX21 in Regulating Human Cytomegalovirus Replication.
Loss of Rubicon ameliorates doxorubicin-induced cardiotoxicity through enhancement of mitochondrial quality.
CXCL13/CXCR5 signaling contributes to diabetes-induced tactile allodynia via activating pERK, pSTAT3, pAKT pathways and pro-inflammatory cytokines production in the spinal cord of male mice.
TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ.
CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer.
Neferine in the Lotus Plumule Potentiates the Antitumor Effect of Imatinib in Primary Chronic Myeloid Leukemia Cells In Vitro.
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.
The Legionella effector RavD binds phosphatidylinositol-3-phosphate and helps suppress endolysosomal maturation of the Legionella-containing vacuole.
β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling.
A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5(+) intestinal stem cell maintenance.
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
The Protective Role of Brain CYP2J in Parkinson's Disease Models.
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy.
BCAT1 promotes proliferation of endometrial cancer cells through reprogrammed BCAA metabolism.
Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity.
Murine Cytomegalovirus Protein pM91 Interacts with pM79 and Is Critical for Viral Late Gene Expression.
Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.
EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer.
UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment.
A Novel Cx50 Insert Mutation from a Chinese Congenital Cataract Family Impairs Its Cellular Membrane Localization and Function.
Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents.
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration.
Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes.
Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.
Ifi27 is indispensable for mitochondrial function and browning in adipocytes.
BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy.
AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming.
Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.
High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake.
ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3.
MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6.
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Low-dose paclitaxel downregulates MYC proto-oncogene bHLH transcription factor expression in colorectal carcinoma cells.
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.
Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.
PMLIV overexpression promotes TGF-β-associated epithelial-mesenchymal transition and migration in MCF-7 cancer cells.
mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells.
Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia.
miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.
Anillin is required for tumor growth and regulated by miR-15a/miR-16-1 in HBV-related hepatocellular carcinoma.
RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Quercetin attenuates AZT-induced neuroinflammation in the CNS.
MCPIP1 is a positive regulator of type I interferons antiviral activity.
CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis.
Legionella Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner.
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
CMIP Promotes Proliferation and Metastasis in Human Glioma.
TGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling.
MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors.
Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.
SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis.
IL-1β Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells.
MAPK/p38 regulation of cytoskeleton rearrangement accelerates induction of macrophage activation by TLR4, but not TLR3.
Hydrogen peroxide promotes the expression of angiopoietin like 4 in RAW264.7 macrophages via MAPK pathways.
Tectorigenin attenuates the MPP(+)-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition.
HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats.
The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes.
Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development.
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.
Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling.
Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.
Mcl-1 suppresses abasic site repair following bile acid-induced hepatic cellular DNA damage.
A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation.
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.
Antithrombin III prevents progression of chronic kidney disease following experimental ischaemic-reperfusion injury.
MDM2 is implicated in high-glucose-induced podocyte mitotic catastrophe via Notch1 signalling.
Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription.
De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.
A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis.
ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus.
Co-expression of podoplanin and fibroblast growth factor 1 predicts poor prognosis in patients with lung squamous cell carcinoma.
Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity by stabilizing type I-interferon receptor.
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.
Visualization of reticulophagy in living cells using an endoplasmic reticulum-targeted p62 mutant.
A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.
Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.
Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells.
Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon.
Suberoylanilide hydroxamic acid represses glioma stem-like cells.
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death.
Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.
Small-Activating RNA Can Change Nucleosome Positioning in Human Fibroblasts.
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring.
Influence of miR-30b regulating humoral immune response by genetic difference.
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.
State estimation and prediction using clustered particle filters.
ERK-mediated NF-κB activation through ASIC1 in response to acidosis.
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria.
SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.
Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.
Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.
Increased stathmin expression strengthens fear conditioning in epileptic rats.
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates.
Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats.
Analysis of grayscale characteristics in images of labeled microtubules from cultured cardiac myocytes.
TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.
Modulation of amylose content by structure-based modification of OsGBSS1 activity in rice (Oryza sativa L.).
Axl receptor tyrosine kinase expression in breast cancer.
lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.
INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity.
Liu Y, Tao J, Tan D, Zheng F, Su Z, Yuan J, Zhu C, Zheng Z, Zhou X, Luo D
Research (Washington, D.C.) 2026;9:1100
Research (Washington, D.C.) 2026;9:1100
Exosomes Derived From Mesenchymal Stem Cells Regulating Myotube Cell Atrophy via NF-κB Signaling Pathway.
Ke Y, Wang Y
Stem cells international 2026;2026:3606738
Stem cells international 2026;2026:3606738
Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.
Zhai MR, Pan J, Wu ZH, He YY, Zhang KR, Ren L, Wang YR, Li YB, Gao J, Xiao L, Liu YH
Theranostics 2026;16(5):2466-2487
Theranostics 2026;16(5):2466-2487
Antibody-induced internalization and degradation of PLA2R amplifies CD4(+) T cell activation.
Liu Y, Li Y, Zhou H, Yu J, Deng P, Xu W, Pan B, Zhang L, Zhou H, Zhang J, Liu X, Shi M, Dong X, Tong B, Bi E, Guo N, Hu Y
Theranostics 2026;16(1):37-57
Theranostics 2026;16(1):37-57
SMURF2 attenuates NRF2-driven tumor progression by acting as a nuclear brake on NRF2 during cellular stress.
Xu W, Dong L, Li J, Fan S, Wang Y, Xia Q
Redox biology 2026 May;92:104102
Redox biology 2026 May;92:104102
USP25 aggravates liver cancer development and impairs chemosensitivity by limiting LATS1 activation.
Li L, Wang X, Yang Y, Zhou Y, Jiang Z, Zhai L, Zhao X, Qiang H, Luo J, Ji Y, Yao J, Zhang T, Wang Y, Li K, Chen L, Chen Y, Yuan J, Li Y
EMBO reports 2026 May;27(9):2406-2433
EMBO reports 2026 May;27(9):2406-2433
Tetraspanin CD82 shapes EGFR signaling outcomes through nanoscale receptor organization.
Restrepo Cruz S, Wester MJ, Pankratz VS, Lidke DS, Lidke KA, Gillette JM
The Journal of cell biology 2026 May 4;225(5)
The Journal of cell biology 2026 May 4;225(5)
DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses.
Vila IK, Messaoud-Nacer Y, Taffoni C, Jardine J, Eloiflin RJ, Augereau A, Guha S, Schussler M, Le Hars P, McKellar J, Carvalho T, Postal J, Chemarin M, Re J, Guivel-Benhassine F, Lopez R, Trillet K, Barrat J, Serbier M, El Mansouri I, Luchsinger C, Chrousos GP, Porrot F, Diaz-Griffero F, Schwartz O, Blanchet FP, Majzoub K, Bidère N, Vlachakis D, Laguette N
The Journal of experimental medicine 2026 May 4;223(5)
The Journal of experimental medicine 2026 May 4;223(5)
Taohong siwu decoction alleviates hand-foot skin reaction by regulating RAGE-mediated keratinocyte apoptosis and autophagy.
Dong H, Liu Z, Yu F, Li J, Zheng Y, Shen Y, Wang A, Wu D, Wang X, Cui H, Peng Y
Journal of ethnopharmacology 2026 May 23;363:121401
Journal of ethnopharmacology 2026 May 23;363:121401
Phenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
Zeng Z, Yin Y, Cong Z, Wei S, Wei X, Shen Z, Ge Q, Zhu X
International immunopharmacology 2026 May 15;177:116541
International immunopharmacology 2026 May 15;177:116541
Novel Dual-Pharmacophore TrxR Inhibitors Integrating Ferroptosis and Antitumor Immunity: A Closed-Loop Strategy for TIME Remodeling.
Xu Z, Yang Z, Lv L, Yang J, Liu W
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827
Journal of medicinal chemistry 2026 May 14;69(9):10811-10827
m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.
Liu S, Ren Q, Mo G, Li Z, Huang H, Zhou Y, Miao Z, Cao X, Wu B, Xiao Z, Yu S, Wu G, Xia L, Cui J, Mo J, Li Y, Xia L, Shen J, Xiao S
The Journal of clinical investigation 2026 May 1;136(9)
The Journal of clinical investigation 2026 May 1;136(9)
p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer.
Tong J, Han T, Deng J, Gan Y, Ruan R, Zhao W, Xiong C, Liao Q, Chen S, Bu H, Xiong J, Zhou X, Hao Q
Redox biology 2026 Mar;90:104043
Redox biology 2026 Mar;90:104043
Trans-Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids.
Ni Z, Cao C, Tian Y, Mu J, Tian H, Wang Z, Zhang S, Cao M, Yang Y, Lim WLF, Cui J, Sun H, Miao H, Wang Y, Du J, Kwok T, Chen H, Lam SM, Shui G
MedComm 2026 Mar;7(3):e70669
MedComm 2026 Mar;7(3):e70669
Anxiety and abnormal hippocampal neurogenesis in adult rat offspring after high-speed train indoor pressure exposure during early pregnancy.
Zhang X, Deng Y, Zhang W, Wang T, Qian B, Dai L
International journal of environmental health research 2026 Mar;36(3):541-553
International journal of environmental health research 2026 Mar;36(3):541-553
Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone-Mediated Autophagy.
Chen J, Lai Y, Li M, Cai Z, Lu R, Liu L, Peng Y, Fu C, Xie Z, Zhou X, Liu J, Zhang H
Journal of cellular and molecular medicine 2026 Mar;30(5):e71062
Journal of cellular and molecular medicine 2026 Mar;30(5):e71062
Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide.
Wu J, Cui G, Lin Z, Lin W, Zhang Y, Zhou T, He P, Zhang Y, Yao G
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1676-1695
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1676-1695
XIAP Stabilizes DDRGK1 to Promote ER-Phagy and Protects Against Noise-Induced Hearing Loss.
Yan L, Zhang Y, Du J, Zhu Y, Cao W, Wei Y, Wu H, Qiu S, Pan S, Chen L, Liang P, Chai R, Yang J, Fang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e11217
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e11217
Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer.
Zhao W, Hao Q, Gan Y, Tong J, Chen X, Tan S, Ruan R, Huang Y, Cao M, Deng J, Han T, Shi G, Gao B, Zhang Y, Zhou X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e13369
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e13369
Regulation of mitophagy by Fis1 and Fascin1-organized actin.
Nakajima S, Wang TY, Chou TF, Chakrabarty Y, Chan DC
Current biology : CB 2026 Mar 9;36(5):1205-1219.e8
Current biology : CB 2026 Mar 9;36(5):1205-1219.e8
Combining Temozolomide with a Selective CK2 Inhibitor Results in Anti-Tumour Effects in Glioblastoma Cell Lines.
Boewe AS, Rumler H, Aichele D, Bödeker T, Laschke MW, Ampofo E, Jose J, Götz C
Molecules (Basel, Switzerland) 2026 Mar 9;31(5)
Molecules (Basel, Switzerland) 2026 Mar 9;31(5)
Remote Ischemic Preconditioning Exerts Neuroprotective Effects Via the PGC-1α/FNDC5/BDNF Pathway in Focal Brain Ischemia of Rats.
Matsuoka T, Matsuzaki R, Nakanishi K, Kakimoto S, Kato Y, Otsuka S, Kikuchi K, Sakakima H
Translational stroke research 2026 Mar 9;17(2)
Translational stroke research 2026 Mar 9;17(2)
Trehalose ameliorates severe acute pancreatitis by modulating gut microbial metabolism.
Hao H, Du D, Lin H, Ke L, Fu A, Shi C, Li W, Li Y, Hou G, Li L, Liu Y, Shao S, Li W, Tong Z
NPJ biofilms and microbiomes 2026 Mar 6;12(1)
NPJ biofilms and microbiomes 2026 Mar 6;12(1)
A small‑molecule HDAC/PDE modulator activates human adipocyte UCP1 and resolves inflammatory signaling.
Rammah M, Romero AR, Halabi N, Abuaqel S, Guennoun A, Dömling A, Shan J, Chouchane L
Journal of translational medicine 2026 Mar 5;24(1)
Journal of translational medicine 2026 Mar 5;24(1)
Knockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity.
Zhuang H, Cao X, Tang X, Liang Z, Wang H, Liu Q, Yan X, Lin X, Su X, Wang M, Huang Y, Lu D, Wang Y, Chen H, Shen L
Translational psychiatry 2026 Mar 30;16(1)
Translational psychiatry 2026 Mar 30;16(1)
Discovery of a Hydroxamic Acid-Based HDAC11 Isoform-Selective Inhibitor with Oral Anti-AML Potency.
Chai Q, Yang M, Liu C, Zhu X, Liu L, Zhao W, Xue X, Zhang J, Liu L, Wang W, Liu F, You X, Zhang Y
Journal of medicinal chemistry 2026 Mar 26;69(6):6816-6834
Journal of medicinal chemistry 2026 Mar 26;69(6):6816-6834
CEP170 as a novel molecular link between centrosomal function and cerebral cortical development.
Liao YC, Tsai MH, Chao NH, Chang YS, Lin TW, Lin IH, Hou PS, Wang WJ, Tsai JW
Journal of biomedical science 2026 Mar 26;33(1)
Journal of biomedical science 2026 Mar 26;33(1)
Ca(2+) influx through ER-plasma membrane contacts is required for brown fat thermogenesis and metabolic health.
Zhou J, Dogan C, Artico LL, Rodrigues K, Hakam S, Kim T, Xu V, Lapenta K, Kang M, Jorgens DM, Widenmaier SB, Parlakgul G, Arruda AP
bioRxiv : the preprint server for biology 2026 Mar 23;
bioRxiv : the preprint server for biology 2026 Mar 23;
Phytosterol alleviates cholesterol accumulation by influencing intestinal esterification rather than competitive solubilization under dietary MUFA.
Zhao T, Zhang Y, Wang Z, Yin J, Nie S, Jiang Y, Sun C, Lu B
Journal of advanced research 2026 Mar 22;
Journal of advanced research 2026 Mar 22;
A cell cycle-dependent transition of acetylation to phosphorylation regulates timely centrosome maturation.
Li J, Liang J, Chen G, Wang X, Wang Y, Zhan J, Guo Y, Wang J, Chen X
Nature communications 2026 Mar 20;17(1)
Nature communications 2026 Mar 20;17(1)
MiR-1290 in natural killer cell derived extracellular vesicles: a pathogenic mediator of lupus nephritis and therapeutic target for th17 regulation.
Cheng C, Su H, Li X, Li R, Yang Q, Guan T, Li M, Ou C
Journal of nanobiotechnology 2026 Mar 2;24(1)
Journal of nanobiotechnology 2026 Mar 2;24(1)
HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
Wang Y, Xiong Y, Liu S, Bao L, Qiu X, Korboukh I, Song X, Toffessi Tcheuyap V, Wu S, Chen M, Brugarolas J, Jin J, Wang Y, Luo W
Cell reports. Medicine 2026 Mar 17;7(3):102630
Cell reports. Medicine 2026 Mar 17;7(3):102630
TONSL promotes hepatocellular carcinoma progression and radioresistance by orchestrating DNA damage repair and cell cycle dynamics.
Luo MR, Liao JL, Fang SJ, Zhang DY, Lei L
Discover oncology 2026 Mar 12;17(1)
Discover oncology 2026 Mar 12;17(1)
Dual roles of GDNF in enteric glial cell plasticity: direct transdifferentiation via the CaMKII/NeuroD1 pathway and cooperative regulation in a neural stem cell-inducing medium.
Jia W, Yan H, Huang J, Liu W, Fu Z, Tian D, Xu W, Chen X, Gao Y, Yu H
Stem cell research & therapy 2026 Mar 11;17(1)
Stem cell research & therapy 2026 Mar 11;17(1)
Astrocyte-Specific Upregulation of Tumor Necrosis Factor Receptor II Ameliorates Pathological Phenotypes in APP(NL-F/NL-F) Mice.
Li D, Li Y, Wen L, Chen Z, Gao F, Shen Y, Wang Q
Neuroscience bulletin 2026 Mar 11;
Neuroscience bulletin 2026 Mar 11;
Targeting HIF-1α promotes ferroptosis and boosts antitumor immunity in MSS colorectal cancer.
Yang Z, Ma R, Wu W, Shi Y, Chen Y, Luo X, Li K, Wu L, Wang B, Zhang B, Yuan P
Redox biology 2026 Jun;93:104151
Redox biology 2026 Jun;93:104151
lncRNA-driven multi-omics reconstitution engineers EVs for macrophage-targeted and anti-inflammatory therapy in MASLD.
Liu L, Li G, He Z, Sun Y, Jiao Z, Zhong J, Wang G, Wang K, Li W
Free radical biology & medicine 2026 Jun;249:230-245
Free radical biology & medicine 2026 Jun;249:230-245
Matrix stiffness promotes corneal fibrosis through the YAP/TAZ-β-catenin mechanotransduction pathway: Proteomic and functional validation.
Li K, Fu H, Miao L, Lu Y, He C, Liu Y, Hu Z, Xie B, Lv X, Lu F, Lin M, Hu L
Acta biomaterialia 2026 Jun;216:215-233
Acta biomaterialia 2026 Jun;216:215-233
Tannic acid inhibits viral replication by disrupting nucleocapsid condensation.
Pan J, Jiang SZ, Zhu Y, Li XW, Yu LB, Wang Z, Shen BL, Luo RB, Fan LJ, Yu Y, Qian BS, Wang ZJ, Liu Y, Cai H, Xue W, Xia T, Han QY, Wang K, Xu X, He XH, Chen Y, Gao Y, Li AL, Li T, Zhang R, Zhao M, Zhou T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158151
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158151
HOMER3 as a prognostic and immune-related biomarker in pan-cancer and esophageal carcinoma: Insights from bioinformatics and functional validation.
Su ZP, Yang N, Cui BQ, Li ZQ, Feng HM, Zhai KR, Ren MY, Chen YZ, Li B
Cellular signalling 2026 Jun;142:112424
Cellular signalling 2026 Jun;142:112424
Gossypol suppresses tumorigenesis through inhibition of multiple deubiquitinating enzymes.
Gui L, Chen C, Gao J, Zhu M, Xu Z, Zhou H, Zhang N, Shi L
Bioorganic chemistry 2026 Jun 15;174:109763
Bioorganic chemistry 2026 Jun 15;174:109763
Design, synthesis, and pharmacological evaluation of novel PROTAC degraders targeting 11β-HSD1 for metabolic disease intervention.
Wang L, Tao X, He M, Lu Y, Wang Y, Zhu J
Bioorganic chemistry 2026 Jun 15;174:109731
Bioorganic chemistry 2026 Jun 15;174:109731
Lathyrane diterpenoids with anti-renal fibrotic activity from the aboveground parts of Euphorbia wallichii.
Ma RF, Liu KY, Pan YB, Zhang H
Phytochemistry 2026 Jul;247:114875
Phytochemistry 2026 Jul;247:114875
Disruption of the nucleocapsid-RNA condensation by punicalagin is a broad-spectrum antiviral approach.
Jiang SZ, Yu LB, Shen B, Pan J, Li XW, Luo RB, Fan LJ, Qian BS, Zhu Y, Wang Z, Liu Y, Li T, Zhang XR, Yu Y, Xue W, Xia T, Cai H, Han QY, Wang K, Xu X, Zhang R, Zhang XM, Li AL, Zhou T, Gao Y, Zhao M, Li T
Fundamental research 2026 Jan;6(1):535-547
Fundamental research 2026 Jan;6(1):535-547
Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer's disease.
He A, Wang Y, Shen Y, Dong Z, Luo L, Ge X, Liu X, Mao Y, Zhang T, Li X, Li H, Jing W, Zhu LQ, Zhang Q, Lu Y
Nature aging 2026 Jan;6(1):181-199
Nature aging 2026 Jan;6(1):181-199
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion.
Jiang M, Zhang J, He J, Miao Y, Wang L, Zhong H, Gong Y, Li Z, Du LL, Xu X, Chen C, Ydyrys A, Xia Y, Cao Q, Lou H, Hou W
The EMBO journal 2026 Jan;45(1):278-309
The EMBO journal 2026 Jan;45(1):278-309
Identification of a Novel Biallelic CFAP119 Variant in an Infertile Man with Asthenoteratozoospermia.
Ma J, Ruan T, Jiang C, Wang X, Zhang Y, Tian Y, Tang X, Yang Y, Shen Y
The world journal of men's health 2026 Jan;44(1):203-215
The world journal of men's health 2026 Jan;44(1):203-215
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
Zhang R, Tan X, Zhang Y, Ma Y, You Z, Huang Y, Yang L
Phytotherapy research : PTR 2026 Jan;40(1):334-350
Phytotherapy research : PTR 2026 Jan;40(1):334-350
The Inhibition of PP1γ2 by PKA Through SRC Initiates Sperm Motility in Tree Shrews.
Yang M, Zhang X, Tan X, Li Y
Journal of experimental zoology. Part A, Ecological and integrative physiology 2026 Jan;345(1):27-38
Journal of experimental zoology. Part A, Ecological and integrative physiology 2026 Jan;345(1):27-38
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion.
Xu J, Liu W, Chen L, Zhang J, Zhang D, Huang X, Zhang G
Cell death and differentiation 2026 Jan;33(1):126-139
Cell death and differentiation 2026 Jan;33(1):126-139
Bio-orthogonal chemistry-based strategy to Turn-OFF CRISPR-Cas9 activity in solution and live cells.
Pandit B, Vangaveti S, Sentre JF, McClain I, Fuchs G, Royzen M
NAR molecular medicine 2026 Jan;3(1):ugag008
NAR molecular medicine 2026 Jan;3(1):ugag008
Astrocyte-specific deletion of ceruloplasmin exacerbates oxidative stress and demyelination in the spinal cord in a murine model of multiple sclerosis.
Kedari KG, Smith Z, Cheli VT, Corral JG, Wang C, Paez PM
Neurobiology of disease 2026 Jan;218:107249
Neurobiology of disease 2026 Jan;218:107249
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels.
Cheng G, Qi C, Xu H, Wang X, Li M, Chen H, Zheng P, Liu Y, Liu J, Zhao X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159705
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159705
Paeoniflorin derivative ameliorates methotrexate resistance in treating rheumatoid arthritis through targeting GRK2-A(2A)AR axis.
Guo P, Wang R, Lu M, Wang M, Chu R, Hu S, Xu H, Fang R, Zhu Z, Cai J, Han Y, Wang C, Wei W, Wang Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157731
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157731
Muskardia inhibits proliferation and migration of human coronary artery smooth muscle cells by regulating SLC7A11 mRNA stability via the hsa_circTEX10-PCBP2 Axis.
Li C, Duan M, Chen Z, He S, Chi B, Zhang X, Ren M, Bie H, Jia Q, An F, Wang G, Jia E
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157709
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157709
Licochalcone B targets neural cell adhesion molecule 1 to inhibit osteosarcoma progression and ferroptosis resistance via extracellular signal-regulated kinase 5 and nuclear factor kappa B pathways.
Wang S, Liang F, Wei H, Huang X, Lin H, Chen F, Lin R, Huang Z, Lin J, Wu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157584
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157584
Therapeutic Targeting of the IRF9/RTN4/RHOA/ROCK Pathway via RVG29-Modified PLGA Nanoparticles and rTMS for Neural and Vascular Regeneration Post-Cerebral Infarction.
Zhang F, Shen W, Zhong S, Wen K, Wang H
Advanced healthcare materials 2026 Jan;15(2):e01846
Advanced healthcare materials 2026 Jan;15(2):e01846
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex.
Hua Z, Ding X, Wu Y, Zhang D, Hu X, Yang P, Li J, Tan Y, Liu J, Zhang M, Zhang M, Liu X, Yu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e11340
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e11340
CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1-Mediated Ubiquitination of NPM1.
Zhang Y, Gao H, Tang A, Lyu H, Fan Z, Guo J, Wang Y, Yi H, Pan Q, Luo H, Qin B, Zhang B, Meng X, Liu Q, Lee MH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e10210
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e10210
Herba Patriniae Component Linarin Induces Cell Cycle Arrest and Senescence in Non-Small-Cell Lung Cancer Associated with Cyclin A2 Downregulation.
Xie W, Li X, Huang D, Xu J, Yu M, Li Y, Wang QK
Pharmaceuticals (Basel, Switzerland) 2026 Jan 8;19(1)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 8;19(1)
High-content phenotyping reveals Golgi dynamics and their role in cell cycle regulation.
Cao X, Peng Y, Yang M, Gan M, Zhang D, Zhou S, Takao D
The Journal of cell biology 2026 Jan 5;225(1)
The Journal of cell biology 2026 Jan 5;225(1)
C-di-AMP sensitizes colorectal cancer to CD47 antibodies by activating NF-κB to promote macrophage phagocytosis.
Hao Y, Fan Y, He H, Zeng Z, Zong Y, Yang Z, Li B, Cheng L
Cell communication and signaling : CCS 2026 Jan 31;24(1)
Cell communication and signaling : CCS 2026 Jan 31;24(1)
DCLK1 drives malignant progression and chemoresistance of bladder cancer by deubiquitinating HDAC6.
Du A, Zhou Y, Deng X, Yuan D, Li K, Luo Y, Tan S, Dai X, Yu B, Jiang K, Tan X, Zhu J
Molecular cancer 2026 Jan 30;25(1)
Molecular cancer 2026 Jan 30;25(1)
Epicatechin Gallate Ameliorates UVB-Induced Photoaging by Inhibiting p38α-Mediated Autophagy and Oxidative Stress.
Yang D, Sun R, Cui Y, Li Y, Hou H, Otsuki K, Li W, Xu J, Zhang P, Zhang J
Antioxidants (Basel, Switzerland) 2026 Jan 30;15(2)
Antioxidants (Basel, Switzerland) 2026 Jan 30;15(2)
Mitochondria-located circRCP regulates redox homeostasis via stabilizing LRPPRC/SLIRP complex to promote bladder urothelial carcinoma tumorigenesis.
Zhou ZH, Wen JH, Zhang YZ, Yao K, Li ZY, Li XD, Wang YJ, Jiang LJ, Ye YL, Qin Z, Liu ZW, Zhou FJ, Chen RX, Xie D, Wei WS
Cancer letters 2026 Jan 28;638:218157
Cancer letters 2026 Jan 28;638:218157
BMP6 as a therapeutic target for preeclampsia: enhancing trophoblast invasion and vascular mimicry.
Niu Y, Han S, Xiao H, Liu M, Yu Y, Klein C, Lan X, Li Y, Yuan H, Zhang P, Wei D
Cellular and molecular life sciences : CMLS 2026 Jan 23;83(1):79
Cellular and molecular life sciences : CMLS 2026 Jan 23;83(1):79
Levistolide A Alleviates Myocardial Ischemia-Reperfusion Injury Partly by Improving Calcium Homeostasis via the ADORA2B/cAMP/PKA/PLB/SERCA2α Signaling Axis.
Li Y, Lu Y, Chen X, Guo M
Current issues in molecular biology 2026 Jan 23;48(2)
Current issues in molecular biology 2026 Jan 23;48(2)
UBE4B Mediates Mitophagy via NIPSNAP1 Ubiquitination and NDP52 Recruitment.
Jin B, Qu J, Xu K, Zhang Y, Xu P, Wang X, Zhao B, Jiao X
International journal of molecular sciences 2026 Jan 22;27(2)
International journal of molecular sciences 2026 Jan 22;27(2)
METTL16-m(6)A-PGC-1α axis contributes to exercise-induced mitochondrial adaptations in skeletal muscle of high-fat diet-fed insulin-resistant mice.
Chen C, Jiang C, Xiang Q, Hu Y, Wu H, Huang C, Zhou H, Xu Y, Hou M, Liu W, Han X
BMC biology 2026 Jan 22;24(1):41
BMC biology 2026 Jan 22;24(1):41
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle.
Balch S, Franco-Echevarría E, Ghanim GE, Kretsch RC, Das R, Nguyen THD
Nature communications 2026 Jan 21;17(1):1847
Nature communications 2026 Jan 21;17(1):1847
METTL14 integrates tumor-derived SAM to drive parabrachial epigenetic rewiring in pancreatic cancer.
Yang X, Wang X, Lu W, Ye Q, Li Y, Ma X, Ye Y, Guo X, Chen G, Xin W, Xu T, Zeng W, Xie J
Neuron 2026 Jan 21;114(2):250-267.e8
Neuron 2026 Jan 21;114(2):250-267.e8
TRPS1 confers paclitaxel resistance in TNBC through dual activation of the PDE4D-cAMP-AKT pathway and microtubule destabilization.
He X, Tong W, Chen X, Huang H, Wei N, Ma J, Liu Y, Ma Y, Li S, Li W, Li H, Ren H
Breast cancer research : BCR 2026 Jan 20;28(1):47
Breast cancer research : BCR 2026 Jan 20;28(1):47
GRP75 blocks hepatitis E virus infection by targeting HEV-ORF2 for degradation through chaperone-mediated autophagy and promoting IRF3 activation.
Wang Y, Li Y, Xu R, Yuan T, Xu C, Zhou Z, Ba C, Zhao Q, Wu C, An Z, Yin X, Yang Y, Nan Y
Journal of virology 2026 Jan 20;100(1):e0134425
Journal of virology 2026 Jan 20;100(1):e0134425
Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1.
Wu L, Liu P, Jiang B, Zhang X, Zhao E, Zhao J, Zhu F, Xu H, Shi K, Jian B
Annals of hematology 2026 Jan 17;105(1):24
Annals of hematology 2026 Jan 17;105(1):24
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
Wang Z, Zhang Z, Xin R, Ma M, Sun Z, Li Z, Zhang C, Liu L, Wu Z, Zhang Y, Chen Y
Inflammation 2026 Jan 16;49(1):49
Inflammation 2026 Jan 16;49(1):49
Ciliopathy-related B9 protein complex regulates ciliary axonemal microtubule posttranslational modifications and initiation of ciliogenesis.
He R, Li Y, Jin M, Jiao H, Shen Y, Han Q, Pan X, Wang S, Lin Z, Li J, Lu C, Meng D, Cao Z, Shang Q, Lv N, Wan K, Gao H, Ma X, Yin H, Chang H, Wang L, Luo M, Pan J, Zhao C, Cao M
The Journal of clinical investigation 2026 Jan 16;136(2)
The Journal of clinical investigation 2026 Jan 16;136(2)
A causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 GWAS locus influences susceptibility to schizophrenia.
Zhou D, Zhang Y, Yang Z, Zhang C, Zhang Q, Huo J, Cui K, Wu Y, Chang H, Wang C, Xiao X, Cai X, Li M
Science advances 2026 Jan 16;12(3):eadw7667
Science advances 2026 Jan 16;12(3):eadw7667
A novel variant p.Y250C of FZD4 influences Norrine/β-catenin signaling pathway that associates with familial exudative vitreoretinopathy (FEVR).
Yang L, Cheng J, Chen M, Ren M, Fu J
Scientific reports 2026 Jan 12;16(1):4438
Scientific reports 2026 Jan 12;16(1):4438
Activation of the integrated stress response contributes to developmental delay and seizures caused by mitochondrial prolyl-tRNA synthetase (PARS2) deficiency.
Xu M, Liu Y, Ma R, Fan W, Duan J, Deng H, Ma Y, Ge W
Redox biology 2026 Feb;89:103966
Redox biology 2026 Feb;89:103966
Redox-dependent protein S-glutathionylation governs azacitidine sensitivity and resistance in AML.
Nemes D, Myšáková M, Minařík L, Jonášová A, Stopka T, Pimková KG
Redox biology 2026 Feb;89:103958
Redox biology 2026 Feb;89:103958
Mechanistic Insights Into NFIX-Mediated DNA Recognition and Transcriptional Regulation in Skeletal Muscle.
Zhu C, Liu S, Chen X, Qin C, Wang Y, Xue C, Li L, Du W, Chen X, Li X, Shen J, Song H
Smart medicine 2026 Feb;5(1):e70027
Smart medicine 2026 Feb;5(1):e70027
TBKBP1 induces capecitabine resistance through negative regulation of type I interferon pathway in triple-negative breast cancer.
Wu WY, Yang YS, Andriani L, Xie YF, Di GH, Shao ZM, Li JJ
Oncogene 2026 Feb;45(6):703-714
Oncogene 2026 Feb;45(6):703-714
3'UTR shortening alleviates miRNA repression of mRNAs critical for muscle stem cell differentiation.
Zhu Y, Wang J, Tong D, Jia P, Chen S, Li Y, Fu J, Li Q, Hu P, Zhou Y, Cheng H
The EMBO journal 2026 Feb;45(3):722-748
The EMBO journal 2026 Feb;45(3):722-748
Treating acute respiratory distress syndrome with a multifaceted nanomedicine: Inhibition of PANoptosis and enhancement of lung barrier integrity.
Cui Y, Wang X, Lu C, Ran L, Guo Z, Yao J, Yu T, Liu X, Li F, Li C, Meng Y, Zhou W
Materials today. Bio 2026 Feb;36:102748
Materials today. Bio 2026 Feb;36:102748
Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells.
Plaza-Sirvent C, Sturm H, Nocke MK, Ghorbani F, Bessen C, Greweling-Pils MC, Floess S, Niemz J, Huysentruyt J, Tougaard P, Huehn J, Geffers R, Todt D, Vandenabeele P, Schmitz I
Cell death and differentiation 2026 Feb;33(2):284-297
Cell death and differentiation 2026 Feb;33(2):284-297
A novel PVA/QCS/AgNP hydrogel with antibacterial and healing-promoting efficacy for preventing postoperative pancreatic fistula in rats.
Zhou Y, Chen F, Lin R, Huang H, Pan M
Colloids and surfaces. B, Biointerfaces 2026 Feb;258:115251
Colloids and surfaces. B, Biointerfaces 2026 Feb;258:115251
Rabeprazole attenuates fibrosis by modulating SMAD3 linker region phosphorylation.
Li L, Liang Z, Fan L, Cao Y, Tang X, Chen J
Biomedical reports 2026 Feb;24(2):25
Biomedical reports 2026 Feb;24(2):25
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.
Hu H, Jiang N, Liu J, Bi J, Liu X, Xu B, Cao Y, Guo W, Fu S
PLoS pathogens 2026 Feb;22(2):e1013975
PLoS pathogens 2026 Feb;22(2):e1013975
MD2 mediates COPD pathogenesis by inducing airway inflammation and ferroptosis through the TLR4/MyD88 pathway.
Xi X, Chen H, Ji H, Xiao T, Liu Z, Chen J, Ge X, Zhang Y, Zhu X
Biochimica et biophysica acta. Molecular basis of disease 2026 Feb;1872(2):168099
Biochimica et biophysica acta. Molecular basis of disease 2026 Feb;1872(2):168099
MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe.
Wang K, Fu Z, Xiong C, Zhang J, Luo Q
Cancer science 2026 Feb;117(2):377-392
Cancer science 2026 Feb;117(2):377-392
Loss of Different Domains of TDRD12 Leads to Distinct Male Infertility-Related Phenotypes.
Tang X, Li J, Tian Y, Zhao C, Jiang X, Jiang C, Wang X, Ma J, Zhang Y, Ruan T, Zhao G, Yang Y, Shen Y
Clinical genetics 2026 Feb;109(2):255-265
Clinical genetics 2026 Feb;109(2):255-265
Effects of incompletely degraded galactomannan on growth performance and immune function of cyclophosphamide-induced immunosuppressed broilers.
Zhang J, Diao X, Jiang Y, Chen Y, Lai C, Huang C, Zhu C, Yong Q
Poultry science 2026 Feb;105(2):106218
Poultry science 2026 Feb;105(2):106218
Disruption of the NDC80-Nek2 axis suppresses glioblastoma stemness and enhances therapeutic efficacy.
Niu R, Gong R, Wang W, Liu M, Xu CX, Liu HL, Lin L, Jiang T, Yin J
Journal of translational medicine 2026 Feb 9;24(1)
Journal of translational medicine 2026 Feb 9;24(1)
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
Ma CS, Han B, Guo JR, Guo JF, Shi CK, Liu YX, Yi WJ, Zhang LY, Deng AJ, Wang YS, He MT
Journal of translational medicine 2026 Feb 7;24(1)
Journal of translational medicine 2026 Feb 7;24(1)
Ginsenoside Rg5 Targets PRDX1 to Disrupt Redox Homeostasis and Induce Mitochondria-Dependent Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells.
Ye HL, Wang YN, Li GA, Jin XH, Wu GT, Li Y, Jin YH
Molecules (Basel, Switzerland) 2026 Feb 5;31(3)
Molecules (Basel, Switzerland) 2026 Feb 5;31(3)
SMYD3 synergises with RACK1 to promote colorectal cancer lung metastasis by recruiting SMAD3.
Bai X, Han D, Chen J, Sheng S, Feng H, Wang H, Xu K, Huang Y, Huang M, Chu X, Chen Y, Lei Z
Cell communication and signaling : CCS 2026 Feb 3;24(1)
Cell communication and signaling : CCS 2026 Feb 3;24(1)
KLF7 as a biomarker for the pre-metastatic state promotes colorectal cancer liver metastasis via TGFβ autocrine signaling.
Fang X, Huang H, Zhao Z, Yang L, Huang F, Li J, Meng Z, He S, Li T, Yang S, Suo M, Lv J, Chen Y, Zhang C, Li N
Cancer letters 2026 Feb 28;639:218123
Cancer letters 2026 Feb 28;639:218123
Comprehensive analysis identifies PKMYT1 as an oncogene and potential prognostic and immunological biomarker in lung adenocarcinoma.
Cai Y, Luo K, Liu M, Zhao H, Li G, Lei Y, Ma D, Zhao Y, Zhang H
Translational cancer research 2026 Feb 28;15(2):102
Translational cancer research 2026 Feb 28;15(2):102
Glioblastoma-secreted C1QL1 orchestrates tumor microtube expansion and neural synaptic pruning to drive malignant synapse formation and recurrence.
Ding C, Dong J, Pan Z, Liu S, Song Q, Yang G, Peng Y, Xie C, Huang Z, Yao W, Wu M, Zhong Y, Zhang W, Zhang Y, Wang S, Ma W, Wang Y
Cancer discovery 2026 Feb 27;
Cancer discovery 2026 Feb 27;
Molecular characterisation of the trafficking rescue of defective ABCB4 variants by roscovitine analogues.
Banet M, Crespi V, Elie J, Riahi Y, Lakli M, Mareux E, Gonzales E, Jacquemin E, Meijer L, Lapalus M, Di Meo F, Falguières T
Scientific reports 2026 Feb 25;16(1)
Scientific reports 2026 Feb 25;16(1)
DAXX governs the silencing of LINE1 during spermatogenesis in mice.
Li Z, Xiong C, Shen J, Tan C, Ma D, Chen J, Liu R, Sun Q, Gong W, Yuan W, Huang M, Huang L, Tan Y, Li G, Luo M
Nucleic acids research 2026 Feb 24;54(5)
Nucleic acids research 2026 Feb 24;54(5)
Single-Molecule Localization Expansion Nanoscopy via Spontaneously Blinking Fluorophores.
Yang L, Zhai T, Chen S, Guan D, Liu Q, Zhang Y
Chemical & biomedical imaging 2026 Feb 23;4(2):217-226
Chemical & biomedical imaging 2026 Feb 23;4(2):217-226
Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism.
Byrd A, Marmorale LJ, Marcinowski S, Dykstra MM, Addison V, Barmada SJ, Buchan JR
The Journal of cell biology 2026 Feb 2;225(2)
The Journal of cell biology 2026 Feb 2;225(2)
PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
Huang Z, Liu X, Chen X, Zhou Y, Chen Q, Liu Y, Zhu H, Cheng K, Feng Y, Dong M, Song L, Wang L, Liu S, Shan T, Kuang S, Dong Y, Vidal-Puig A, Zhang Y, Jia Z
Nature communications 2026 Feb 2;17(1)
Nature communications 2026 Feb 2;17(1)
TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis.
Zhang P, Wu D, Wei Y, Su S, Zha X, Liu X, Zhang T, Huang Q, Chen Q, Bao Z, Fan S, Xia L, Peng X
Cell death & disease 2026 Feb 19;17(1)
Cell death & disease 2026 Feb 19;17(1)
Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer.
Yu X, Ren Y, Luo J, Jiang J, Wang L, Mao X, Wang Y, Xie L, Xi Y, Huang H, Zhao C, Hu Y
Cell reports. Medicine 2026 Feb 17;7(2):102621
Cell reports. Medicine 2026 Feb 17;7(2):102621
Association of Variants in CDC10 (Septin 7) Gene with Growth-Related Traits in Qinchuan Cattle.
Cheng Z, Yue Y, Wang Y, Zhou P, An X, Xu J, Yamada T, Cheng G, Bao H, Zan L, Tong B
Animals : an open access journal from MDPI 2026 Feb 1;16(3)
Animals : an open access journal from MDPI 2026 Feb 1;16(3)
Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination.
Liu Q, Deng F, Chen A, Liu Y
Renal failure 2026 Dec;48(1):2630492
Renal failure 2026 Dec;48(1):2630492
Sodium butyrate promotes enteric glial cells neurogenesis by inhibiting Kdm2a and inducing Klf4 expression.
Jia W, Liu W, Tian D, Yan H, Huang J, Fu Z, Xu W, Chen X, Gao Y, Yu H
Journal of pediatric surgery 2026 Apr;61(4):162428
Journal of pediatric surgery 2026 Apr;61(4):162428
Remimazolam alleviates blood-brain barrier damage by regulating the PI3K/AKT signaling pathway in sepsis-associated encephalopathy mice.
Xu B, Wang X, Liu S, Guo Y, Dong Q, Tao Y, Zhang M, Ni P, Xie Y
Brain research bulletin 2026 Apr;237:111824
Brain research bulletin 2026 Apr;237:111824
CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis.
Zhou H, Fu W, Liu S, Zhang Z, Luo H, Zhong Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e02239
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e02239
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin.
Zhang J, Huang Y, Chen Y, Zhang Y, Chen J, Huang Y, Zhong H, He H, Dai X, Yan X, Chen W, Ye Q, Chen X, Zhang J
Immunity 2026 Apr 9;
Immunity 2026 Apr 9;
BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis.
Wu T, Qi S, Shi C, Wu C, Liu Q, Hu C, Hu J, Wang A, Liu J, Qi Z, Wang W, Liu Q
Signal transduction and targeted therapy 2026 Apr 8;11(1)
Signal transduction and targeted therapy 2026 Apr 8;11(1)
A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks.
Llorente A, Arora GK, Loughran RM, Murad R, Maurya S, Crabtree S, Portillo B, Chapagain P, Huluka H, Eron S, Goodman K, Ye G, Blind RD, Emerling BM
The Journal of biological chemistry 2026 Apr 24;:113071
The Journal of biological chemistry 2026 Apr 24;:113071
Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains.
Sahu AK, Minetti A, Di Fraia D, Marino A, Winterhalter PR, Giustarini D, Rossi R, Simm A, Neri F, Galvagni F, Gerhardt C, Pfirrmann T, Ori A
Nature communications 2026 Apr 21;17(1)
Nature communications 2026 Apr 21;17(1)
OTUB1 stabilizes PRRSV matrix protein through a non-canonical deubiquitination mechanism to promote viral replication.
Liu B, Liang W, Li X, Jiang S, Shi Z, Liu N, Zhu R, Dong X, Zhou H, Zhou B, Cui J
Journal of virology 2026 Apr 21;100(4):e0186825
Journal of virology 2026 Apr 21;100(4):e0186825
Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation.
Zuo Y, Wang Q, Tian W, Wang X, Zheng Z, He W, Zhang R, Zhao Q, Miao Y, Yuan Y, Zhang T, Cui Q, Zhang Y, Liu C, Zhou H, Zheng H
Cell 2026 Apr 2;189(7):1975-1989.e19
Cell 2026 Apr 2;189(7):1975-1989.e19
Template-driven scaffolding of SCF(FBXO42) regulates PP2A degradation.
Coassolo S, Michaelian N, Maculins T, Azumaya CM, Cheung TK, Yin J, Zilberleyb I, Pahuja KB, Garner T, Lau T, Mau D, Grimmer M, Fortin JP, Costa M, Dimitrova YN, Rose CM, Hsu PL, Yauch RL
Nature 2026 Apr 15;
Nature 2026 Apr 15;
Moxibustion delays ovarian aging by regulating mitochondrial biogenesis and improving oocyte quality.
Yin Y, Xu Y, Li Z, Chen M, Song Z, Li H, Lu G, Shen M
Chinese medicine 2026 Apr 10;21(1)
Chinese medicine 2026 Apr 10;21(1)
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.
Konishi S, Enkhbayar K, Liu S, Miyashita N, Kobayashi Y, Hutchison V, Sai A, Agarwal P, Witonsky J, Jackson ND, Seibold MA, Chen J, Tata A, Tata PR
The Journal of clinical investigation 2026 Apr 1;136(7)
The Journal of clinical investigation 2026 Apr 1;136(7)
CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway.
Gu J, Dai Z, Shen T, Chen X, Yang Z, Sun S, Chen D, Luo H, Wang X, Xu J
Cancer drug resistance (Alhambra, Calif.) 2025;8:52
Cancer drug resistance (Alhambra, Calif.) 2025;8:52
Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer.
Yang R, Yuan D, Liang C, Zhu S, Huang J, Zhang Y, He W, Li Q, Zhang H
Oncology research 2025;33(12):3945-3971
Oncology research 2025;33(12):3945-3971
Multiaction Antimicrobial, Anti-inflammatory, and Prohealing Hydrogel as a Novel Strategy for Preventing Postoperative Pancreatic Fistula.
Zhou Y, Li L, Chen F, Huang T, Pan M, Huang H
Biomaterials research 2025;29:0194
Biomaterials research 2025;29:0194
TGF-β1/SMAD3-mediated Non-canonical Hedgehog Signaling Promotes Pancreatic Stellate Cell Activation and Fibrosis in Chronic Pancreatitis.
Peng L, Hu Y, Zhang X, Tan C, Yang C, Liu T, Ferdek PE, Yin S, Wang L, Huang W, Zhang Y
International journal of biological sciences 2025;21(15):6978-6996
International journal of biological sciences 2025;21(15):6978-6996
RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells.
Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M
Drug design, development and therapy 2025;19:67-82
Drug design, development and therapy 2025;19:67-82
Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway.
Shi Y, Tang Y, Sun Z, Sui P, Shao Y, Wang Z, Zhang J, Gao M
Drug design, development and therapy 2025;19:51-64
Drug design, development and therapy 2025;19:51-64
Exploring the Therapeutic Mechanism of Jianpi Zhidong Decoction on Tourette Syndrome Based on Proteomics and Network Pharmacology.
Zhang N, Zhang H, Guo J, Ma Y, Bai X, Ma N, Ji X, Meng Y, Li H, Sangwanit T, Shi Y, Zhao J, Li X, Lin J, Cui X
Drug design, development and therapy 2025;19:3139-3158
Drug design, development and therapy 2025;19:3139-3158
Suppression of Inflammation by Si Miao San in Experimental Rheumatoid Arthritis Through Modulation of the AKT/ROS/Autophagy Axis.
Zhang H, Jiang H, Wei Q, Xu J, Zhao Z, Sun Y, Lu Q
Journal of inflammation research 2025;18:9459-9476
Journal of inflammation research 2025;18:9459-9476
Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization.
Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H
Journal of inflammation research 2025;18:1395-1412
Journal of inflammation research 2025;18:1395-1412
A tumor immune microenvironment gene expression signature for predicting prognosis, immunotherapy efficacy, and drug candidates in triple-negative breast cancer.
Bai L, Zhou Z, Yu Q, Ye Z, Li Q, Li S, Li C, Hu Y, Hu Y, Tai X, Xiang L, Sun S, Deng J, Wang Y, Wang D
Frontiers in immunology 2025;16:1676768
Frontiers in immunology 2025;16:1676768
Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism.
Zhao Q, Zhong Y, Li Z, Tang J, Pi C, Zheng W, Shi P, Zuo Y, Jiang J, Yang Y, Chu S, Wei Y, Zhao L
Frontiers in pharmacology 2025;16:1632647
Frontiers in pharmacology 2025;16:1632647
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Yan Y, Fang M, Zhao C, Lin X, Tong C, Xiang C, Ran Y, Wang X, Li S, Chen G, Fu L
Frontiers in pharmacology 2025;16:1542296
Frontiers in pharmacology 2025;16:1542296
Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer.
Zhou S, Li D, Quan C, Yu Z, Feng Y, Wang S, Li Y, Qi T, Chen J
Frontiers in pharmacology 2025;16:1534974
Frontiers in pharmacology 2025;16:1534974
The type I ribosome-inactivating protein α-MMC induced significant apoptosis of lung cancer A549 and 95-D cells by activating the caspase cascade through TNF signaling pathway.
Yang D, Peng D, Li H, Jia D, Zhou Y, Hu B, Chen W, Meng Y
Frontiers in pharmacology 2025;16:1529151
Frontiers in pharmacology 2025;16:1529151
Peptostreptococcus anaerobius promotes cervical cancer angiogenesis by upregulating SCD to activate ERK pathway.
Gong Y, Zhou G, Gu Y, Zhang M, Zhang G, Gu Z, Chen J, Zhou H, Ding J
American journal of cancer research 2025;15(7):3236-3244
American journal of cancer research 2025;15(7):3236-3244
Comprehensive exome profiling identifies ARHGEF12 mutation as a driver in gastric cancer with ovarian metastasis.
Zhang M, Chen G, Lin X, Zhang Y, Shi L, Li S, Li Y, Xiao X, Feng H
Theranostics 2025;15(16):8202-8221
Theranostics 2025;15(16):8202-8221
SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.
Wang X, Hu G, Shao Y, Dong Z, Liu L, Wang Y, Xie Y, Yu N, Zhu C, Wei F, Jia Y, Wang Y, Cai Q
Theranostics 2025;15(13):6369-6386
Theranostics 2025;15(13):6369-6386
Aberrant sialic acid metabolism promotes metabolic reprogramming and metastasis in breast cancer.
Yang L, Li Z, Wang M, Xiong X, Zhang S, Man Z, Dong C, Fu L
Frontiers in oncology 2025;15:1698087
Frontiers in oncology 2025;15:1698087
Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML.
Zhou Y, Jian S, Lu L, Li X, Qiu R
Frontiers in oncology 2025;15:1657508
Frontiers in oncology 2025;15:1657508
Screening and identification of protein 29 of Echinococcus granulosus interacting molecules.
Shang Z, Qiao F, Li Y, Ma X, Wang M, Yang W, He T, Ma H, Wang Y
Frontiers in cellular and infection microbiology 2025;15:1560436
Frontiers in cellular and infection microbiology 2025;15:1560436
Recombinant Antithrombin Alleviated Pulmonary Injury and Inflammation in LPS-Induced ARDS by Inhibiting IL17a/NF-κB Signaling.
Yang C, Fu C, Wang M, Zheng J, Gao Y, Zhu H, Li H, Li D, Guo L, Yu B, Dai Q
ImmunoTargets and therapy 2025;14:433-449
ImmunoTargets and therapy 2025;14:433-449
Melk facilitates pulmonary artery smooth muscle cell proliferation and migration in pulmonary hypertension via modulation of YAP/TAZ signaling.
Yang Q, Chen P, He X, Jian J, He M, Lin T, Zheng S, Liu D
Frontiers in cell and developmental biology 2025;13:1693346
Frontiers in cell and developmental biology 2025;13:1693346
An integrative pan-cancer analysis of USP37 and functional validation in pancreatic cancer.
Chen J, Lin L, Chen D, Wang J, Zhou W
Frontiers in cell and developmental biology 2025;13:1659747
Frontiers in cell and developmental biology 2025;13:1659747
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice.
Cheng W, Wang C, Ma M, Zhou Y
Frontiers in cell and developmental biology 2025;13:1529901
Frontiers in cell and developmental biology 2025;13:1529901
Polycyclic Polyprenylated Acylphloroglucinols from Hypericum himalaicum.
Liu GH, Wu F, Huo XY, Sun HB, Jin ZL, Gu YC, Guo DL, Zhou Y
Planta medica 2025 Sep;91(10-11):576-589
Planta medica 2025 Sep;91(10-11):576-589
GSK3A promotes human adenovirus replication and phosphorylates viral L4-22K protein.
Lin Y, Zhu Y, Jing L, Chen Y, Xiao X, Lei X, Xie Z
Life science alliance 2025 Sep;8(9)
Life science alliance 2025 Sep;8(9)
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Yan Y, Huang Z, Cheng L, Zhao S, Gao H, Chen K, Huang F, Mou L, Chen G, Fu L, Xu G
Toxicology and applied pharmacology 2025 Sep;502:117424
Toxicology and applied pharmacology 2025 Sep;502:117424
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma.
Wang JY, Chen MP, Jiang JX, Wan YK, Li X, Zhang YW, Fang Y, Huang HH, Qin ZY, Hou J
Acta pharmacologica Sinica 2025 Sep;46(9):2496-2508
Acta pharmacologica Sinica 2025 Sep;46(9):2496-2508
Deubiquitinase-dependent transcriptional silencing controls inflammation.
Yi Y, Xu W, Mi P, Ye S, Chen L, Alto NM, Liu Z
Cell research 2025 Sep;35(9):675-686
Cell research 2025 Sep;35(9):675-686
Tumor-derived exosome-based microRNA-206 delivery system as dual modulators of the immune microenvironment and gut microbiota for colorectal cancer therapy.
Tian J, Liu M, Yang X, Wang T, Zhou R, Liu J, Ma B, Su C, Duan X
International journal of biological macromolecules 2025 Sep;321(Pt 4):146489
International journal of biological macromolecules 2025 Sep;321(Pt 4):146489
Roles of human SPATA3 in cell proliferation and expression pattern of Spata3 in mouse testis.
Fu L, Zhou B, Jiang X, Cheng J, Wu Q, Fu J
Molecular medicine reports 2025 Sep;32(3)
Molecular medicine reports 2025 Sep;32(3)
NMDA-Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1-TBX3-Nav1.5 Axis.
He Y, Zhang H, Zhang Q, Sun Z, Sun X, Xia L, Zheng L, Wang L
Acta physiologica (Oxford, England) 2025 Sep;241(9):e70085
Acta physiologica (Oxford, England) 2025 Sep;241(9):e70085
Potent Anti-Cancer Activity of Benzo[d]Thiazole-Isatin Conjugates: Induces S Phase Arrest and Cell Necrosis in A549 and HepG2 Cells.
Saeed BA, Ahmed WU, Alshekh AA, Wu L, Lu Y, Mirgany TO, Kadi AA, Alwabli RI, Wang N, Rahman AFMM
Chemistry & biodiversity 2025 Sep;22(9):e202500575
Chemistry & biodiversity 2025 Sep;22(9):e202500575
Exosome-mediated microglia-astrocyte interactions drive neuroinflammation in Parkinson's disease with Peli1 as a potential therapeutic target.
Guo M, Guan A, Zhang M, Li H, Liu W, Wu B, Shen W, You T, Liang S, Dong Q, Yu J, Zhao Y, Cui M
Pharmacological research 2025 Sep;219:107908
Pharmacological research 2025 Sep;219:107908
Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.
Liu Y, Feng Q, Zou L, Zhu C, Xia W
Andrology 2025 Sep;13(6):1541-1555
Andrology 2025 Sep;13(6):1541-1555
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Li H, Cai S, Mu H, Chang T, Wang X, Tang T, Dong T, Zhang Y, Zhang L, Li H, Zhou L, Xiang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Sex hormone-binding globulin restrains hepatic fibrosis via inhibition of Tgfβ expression.
Lee SR, Mukae M, Hong EJ
Journal of molecular medicine (Berlin, Germany) 2025 Sep;103(9):1043-1053
Journal of molecular medicine (Berlin, Germany) 2025 Sep;103(9):1043-1053
A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage.
Moss T, Wooldredge A, Bhakta K, Cronin M, Gestwicki JE, Mukherjee S
bioRxiv : the preprint server for biology 2025 Sep 6;
bioRxiv : the preprint server for biology 2025 Sep 6;
Single-cell RNA sequencing identifies a unique ZEB2-Regulated Clec4d(+) macrophage state contributing to early inflammatory injury in cardiac hypertrophy.
Zhang MY, Zhang B, Tao QQ, Wang XY, Guan XX, Dong Z, Guo XF, Qi WY, Cheng WZ, Zhang XY, Xu FY, Qiao Y, Zhang BW, Jiang Y, Xu CQ
European journal of pharmacology 2025 Sep 5;1002:177867
European journal of pharmacology 2025 Sep 5;1002:177867
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.
Guo M, Yuan Z, Jin X, Li X, Deng Y, Zhou S, Niu R, Bae J, Park JB, Shi B, Yin J
Nature communications 2025 Sep 30;16(1):8642
Nature communications 2025 Sep 30;16(1):8642
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.
Rao Z, Chen Z, Bao Y, Lu Z, Tang Y, Zhu J, Ma J, Dong S, Shi J, Sheng S, Chen Y, Wang J, Mukondiwa AV, Li Z, Wang X, Huang Z, Li C, Ding W, Chen M, Han Z, Wang C, Pan X, Wang X, Zhu H, Lin L, Huang Z, Lu W, Li X, Luo Y
Signal transduction and targeted therapy 2025 Sep 26;10(1):315
Signal transduction and targeted therapy 2025 Sep 26;10(1):315
NCAPH-YAP1 interaction promotes breast cancer stemness and tumor progression.
Qiu C, Wei Y, Li J
Stem cell research & therapy 2025 Sep 25;16(1):494
Stem cell research & therapy 2025 Sep 25;16(1):494
Human cytomegalovirus promotes de novo PC synthesis during early virus replication.
Kline I, Mokry RL, Xi Y, Passols Manzano M, Layesa S, Sohrab Ali N, Moy MA, Goodrum FD, Purdy JG
Journal of virology 2025 Sep 23;99(9):e0057925
Journal of virology 2025 Sep 23;99(9):e0057925
Phosphorylation enables progressive microtubule-associated protein proteolysis and functionalisation during neural development.
Yang Z, Liczmanska M, Hogg EKJ, Wallace I, Zhou H, Gourlay R, Squires I, Li Z, Hao Y, Brown F, Toth R, Macartney T, Hastie CJ, Qi YA, Gierlinski M, Bustos F, Findlay GM
bioRxiv : the preprint server for biology 2025 Sep 20;
bioRxiv : the preprint server for biology 2025 Sep 20;
Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response.
Zhu T, Li H, Mao S, Zhu Y, Cao H, Zhang Q, Zhen N, Zhang H, Tian Y, Guo Y, Sun T, Li L, Lu J, He H, Xie L, Mi T, Chen Q, Zhao Z, Jiang H, Lu W, Yin B, Zhu J, Pan Q, Xie J, Zhu G
Molecular cell 2025 Sep 18;85(18):3425-3442.e10
Molecular cell 2025 Sep 18;85(18):3425-3442.e10
Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers.
Sealover NE, Finniff BA, Hughes JM, Sheffels E, Lee H, LaMorte JP, Gambhir V, Beckley Z, Linke A, Wilkerson MD, Yohe ME, Kortum RL
Science signaling 2025 Sep 16;18(904):eadx5186
Science signaling 2025 Sep 16;18(904):eadx5186
Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells.
Liu G, Zhang H, Chen S, Gao J, Zhao H, Dong Y, Liu C, Wei X, Li T, Lu C, Zhu H, Lu D, Feng S, Li T, Zhang W, Xia Q, Man J, Zhou T, Chen J, Li A, Pan X
Cancer research 2025 Sep 15;85(18):3416-3434
Cancer research 2025 Sep 15;85(18):3416-3434
Polystyrene nanoplastics promote muscle cell senescence through microtubule hyper-stabilization-mediated mitophagy dysfunction and cGAS-Sting activation.
Cui J, Yue X, Zhang Y, Wang B, Mu A, Ren S, Shao L, Zhu S, Zhang N, Lu Y, Cui H, Li D, Mu X
Journal of hazardous materials 2025 Sep 15;496:139232
Journal of hazardous materials 2025 Sep 15;496:139232
Thyroid hormone ameliorates ursodeoxycholic acid-induced heart damage in zebrafish embryos.
Wu H, Wang X, Li H, Li C, Zhu J, Hu J, Zhang C, Zhou X
Life sciences 2025 Sep 15;377:123716
Life sciences 2025 Sep 15;377:123716
Erucic acid impairs male fertility by suppressing retinoic acid synthesis in sertoli cells.
Jiaming S, Xie G, Xinlong W, Jun J, Yijian X, Ting T, Zhaowanyue H, Jinzhao M, Chun C, Tian D, Rujun M, Kai Z, Zhiyong L, Hongli Y, Bing Y
Ecotoxicology and environmental safety 2025 Sep 15;303:118971
Ecotoxicology and environmental safety 2025 Sep 15;303:118971
Exposure to diethyl phthalates impairs ovarian reserve and oocyte maturation in female mice.
Chen J, Chen L, Chen Y, Jiao Z, Zhang H, Chen C, Yuan Y, Chen Z, Lu Y, Du J
Ecotoxicology and environmental safety 2025 Sep 15;303:118956
Ecotoxicology and environmental safety 2025 Sep 15;303:118956
Discovery of indole derivatives as STING degraders.
An Y, Zhang Y, Luo X, Lan Y, Geng M, Duan W, Xie Z, Zhang H
European journal of medicinal chemistry 2025 Sep 15;294:117747
European journal of medicinal chemistry 2025 Sep 15;294:117747
Loss of TEX30 leads to male subfertility in mice.
Sun Q, Li Z, Wang B, Cheng M, Shen J, Luo M, Liu R
Biology of reproduction 2025 Sep 15;113(3):672-685
Biology of reproduction 2025 Sep 15;113(3):672-685
Papain-like protease of SARS-CoV-2 inhibits dsRNA-induced type I interferon response partly by cleaving TBK1.
Zheng WH, Ni RZ, Ran XH, Mu D
Biochemical and biophysical research communications 2025 Sep 1;777:152244
Biochemical and biophysical research communications 2025 Sep 1;777:152244
Chemical coupling of an active/passive dual-targeting fusion protein ER(Fv)-HSA to DM1 improves its tumor-specificity and therapeutic efficacy against pancreatic cancer.
Wang Y, Geng J, Gong JH, Li Y, Liu XJ, Sheng WJ, Zhen YS
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Sep 1;212:107188
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Sep 1;212:107188
Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis.
Zhang S, Liang Z, Wu C, Qin Z, Wei X, Liu Y, Su R, Li L, Sun B, Huang L, Wang W, Shen J, Wang G, Qi S
Chinese medicine 2025 Sep 1;20(1):141
Chinese medicine 2025 Sep 1;20(1):141
Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer.
Guo M, Wang YJ, Shi J, Cao LX, Ou Y, Jia X, Qi CC, Li ZX, Liu YX, Zuo SY, Shuai QY, Yu TW, Hu HY, Chen X, Feng MD, Xue Y, Wang H, Sun PQ, Liu L, Shi Y, Yang S
Redox biology 2025 Oct;86:103834
Redox biology 2025 Oct;86:103834
Pregnane X Receptor Activation Induces Ferroptosis Resistance Through Upregulation of FSP1.
Shang Y, Yao Q, Tan Y, Bian R, Ma Y, Zhou Y, Mu R, Xu N, Shi Y, Lu N, Liu L, Chen J, Xu S, Li H
Molecular carcinogenesis 2025 Oct;64(10):1620-1637
Molecular carcinogenesis 2025 Oct;64(10):1620-1637
Neuroprotective Effect of Salvianolic Acid C in Neonatal Rats Following Hypoxic-ischemic Brain Damage.
Dai C, Li X, Dong Z, Xu B, Lai X, Wei J, Long D, Hu D
Molecular neurobiology 2025 Oct;62(10):13363-13378
Molecular neurobiology 2025 Oct;62(10):13363-13378
Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases.
Liu C, Zhang H, Mao J, Zhang S, Tian X, Zhu Y, Wang C, Fang J, Pan H, Kang N, Zhang Y, Zhou J, Zhen X, Yan G, Li C, Hu Y, Ye C, Xie R, So C, Sun H, Ding L
Nature aging 2025 Oct;5(10):2022-2038
Nature aging 2025 Oct;5(10):2022-2038
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis.
Yang XZ, Zhang WK, Zhu ZQ, Zhao W, Luo LL, Wang LP, Zhao YJ, Chang Y, Wei W
Acta pharmacologica Sinica 2025 Oct;46(10):2693-2706
Acta pharmacologica Sinica 2025 Oct;46(10):2693-2706
KDM1A-driven RNF81 downregulation promotes gastric cancer progression via KLF4 destabilization.
Wang F, Hao P, Pu Y, He X, He Q, Cui H, Jiang S
Oncogene 2025 Oct;44(40):3864-3878
Oncogene 2025 Oct;44(40):3864-3878
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Li M, Dong W, Cui Y, Li J, Yang C, Zhang D, Fu X
Materials today. Bio 2025 Oct;34:102233
Materials today. Bio 2025 Oct;34:102233
Downregulation of miR-127-5p promotes idiopathic epiretinal membrane development via GLUL-mediated Müller cell activation.
Ying J, Gui Q, Hua S, Li H, Wang T, He D, Zou J, Yi Q
Experimental eye research 2025 Oct;259:110561
Experimental eye research 2025 Oct;259:110561
Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications.
Chen J, Peng W, Yang W, You Z, Zou Y
Experimental eye research 2025 Oct;259:110531
Experimental eye research 2025 Oct;259:110531
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.
Zhang Z, Guo X, Liu Y, Ke P, Meng Y, Gu J, Hu L, Yuan Z, Duan R, Luo J, Xiao F
Free radical biology & medicine 2025 Oct;238:1-16
Free radical biology & medicine 2025 Oct;238:1-16
Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis.
Chen W, Liu S, Zhou Y, Liu B, Wang W, Chen C, Lou Z, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115657
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115657
Electroacupuncture combined with subanesthetic alfaxalone as a novel target for alleviating neuropathic pain.
Liu L, Abouelfetouh MM, Ding Y, Qianghui L, Sun R, Salah E, Nan S, Ding M, Song Y
Pain reports 2025 Oct;10(5):e1296
Pain reports 2025 Oct;10(5):e1296
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer.
Xiao Y, Xu Y, Wang H, Yang F, Ding XH, Fu T, Chen L, Jin X, Zhao YX, Wang Y, Chen F, Shao ZM, Jiang YZ
Cell metabolism 2025 Oct 7;37(10):2030-2047.e7
Cell metabolism 2025 Oct 7;37(10):2030-2047.e7
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Li L, Zuo A, Yin R, Liu Q, Liu C, Li N, Xu D, Zhang S, Li J, Lei S, Ruan S, Li T, Guo Y
Cell death & disease 2025 Oct 7;16(1):710
Cell death & disease 2025 Oct 7;16(1):710
E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity.
Hayase J, Yang L, Zhou YH, Wang K, Xu CR, Bi E
bioRxiv : the preprint server for biology 2025 Oct 6;
bioRxiv : the preprint server for biology 2025 Oct 6;
10-Hydroxy-2-decenoic acid ameliorates LPS-induced acute lung injury through targeting MD2-mediated inflammatory signaling pathways.
Shu C, Li C, Liu H, Zhou Z, Qian C, Xie Z, Lin F, Jiang Y, Chen R, Liu Y, Liu X, Chen G, Fu L
Toxicology and applied pharmacology 2025 Oct 4;505:117589
Toxicology and applied pharmacology 2025 Oct 4;505:117589
Multidimensional analysis of hsa-miR-140-3p and CKS1B correlation via the MAPK/ERK pathway in lung adenocarcinoma progression.
Luo K, Liu M, Song Y, Zhao H, Cai Y, Chen S, Lei Y, Ma D, Zhang H, Zhao Y
Discover oncology 2025 Oct 31;16(1):1996
Discover oncology 2025 Oct 31;16(1):1996
Reactive Oxygen Species (ROS) Drive Osteocyte Dysfunction in Diabetic Osteoporosis by Impairing Autophagy and Triggering Apoptosis.
Han M, Zhao M, Bai F, Wang M, Zhang B, Shi J, Liu Z
Antioxidants (Basel, Switzerland) 2025 Oct 30;14(11)
Antioxidants (Basel, Switzerland) 2025 Oct 30;14(11)
Mitotic DNA repair by TMEJ suppresses replication stress-induced nuclear envelope reassembly defect.
Ye G, He Y, Zhang Y, Li D, Liu F, Li Y, Ge Q, Guo Q, Han S, Song C, Chang W, Zhang H, Peng Q, Sun K, Ji W, Deng L
Nature communications 2025 Oct 3;16(1):8836
Nature communications 2025 Oct 3;16(1):8836
CRL4(DCAF12) regulation of MCMBP ensures optimal licensing of DNA replication.
Yadav AK, Abdirov A, Ondruskova K, Negi S, Jamrichova K, Kolarova K, Dibus N, Krejci J, Polasek-Sedlackova H, Cermak L
Nature communications 2025 Oct 27;16(1):9391
Nature communications 2025 Oct 27;16(1):9391
HuoXue QianYang QuTan recipe attenuates myocardial hypertrophy in obese hypertensive rats by regulating MPC1/MCT4 mediated pyruvate-lactate metabolic axis.
Wang J, Wang M, Li J, Li D, Fu D
Chinese medicine 2025 Oct 23;20(1):180
Chinese medicine 2025 Oct 23;20(1):180
Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model.
Lei C, Zhang B, Yamaguchi J, Tamura R, Zhong W, Cao X, Liu Y, Seki M, Suzuki Y, Suzuki K, Tanida I, Uchiyama Y, Hisatsune T
Journal of neuroinflammation 2025 Oct 21;22(1):237
Journal of neuroinflammation 2025 Oct 21;22(1):237
Molecules interacting with CasL-Like 2 enhances tumor angiogenesis and progression by activating mTOR/HIF1α/VEGF pathway in kidney renal clear cell carcinoma.
Song Y, Zhang J, Liu G, Jiang X, Sun N, He H, Song S, Wang W
Scientific reports 2025 Oct 21;15(1):36581
Scientific reports 2025 Oct 21;15(1):36581
Synthetic Multidomain Proteins Containing Unstructured and α‑Helical Linkers Reveal a Differential Impact of Molecular Crowding on Catalytic Activity and Conformation.
Sultana A, Geethakumari AM, Ahmed WS, Biswas KH
ACS omega 2025 Oct 21;10(41):47879-47893
ACS omega 2025 Oct 21;10(41):47879-47893
Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.
Padmanarayana M, Sakalas S, Sarkar P, Ma M, Garvin ER, Lee E, Corsello SM, Guettler S, Pusapati GV, Rohatgi R
bioRxiv : the preprint server for biology 2025 Oct 21;
bioRxiv : the preprint server for biology 2025 Oct 21;
RIPK4 promotes epidermal differentiation through phase separation and activation of LATS1/2.
Cao X, Lu Z, Fang Y, Huang F, Tang M, Wu B, Gao L, Zhao Y, Zhang T, Zhu Z, Si Y, Guo X, Liu J, Ye C, Song H, Lu H, Feng XH, Shen L, Li L, Zhao B
Developmental cell 2025 Oct 20;60(20):2761-2776.e11
Developmental cell 2025 Oct 20;60(20):2761-2776.e11
Licochalcone D Alleviates Radiation-Induced Intestinal Injury via SIRT3-Dependent Mitophagy: A Natural Phytochemical Strategy for Radioprotection.
Zhang J, Ma S, Wang Z, Wang P, Liu H, Wang Q
Journal of agricultural and food chemistry 2025 Oct 15;73(41):26035-26047
Journal of agricultural and food chemistry 2025 Oct 15;73(41):26035-26047
Metformin activates autophagy and inhibits apoptosis and fetal heart abnormalities via the Dnmt3l/Usp18/STAT1 pathway.
Wei Y, Meng R, Chen X, Guan L, Yu J, Wu Y, Shi C, He J, Su D, Ma X, Sun L
European journal of pharmacology 2025 Oct 15;1005:177997
European journal of pharmacology 2025 Oct 15;1005:177997
11α-hydroxyprogesterone dampens lung metastasis via EMT modulation in PyMT-induced breast cancer murine model.
Kim N, Lee J, Song AY, Mukae M, An BS, Hong EJ
Laboratory animal research 2025 Oct 14;41(1):26
Laboratory animal research 2025 Oct 14;41(1):26
Blockade of TGF-β1/Smad3 signaling pathway by Bovine Milk-derived extracellular vesicles ameliorates skin fibrosis in systemic sclerosis mice.
Chi J, Li X, Zhu Z, Yang L, Luo C, Chen X, Yuan L, Lu Y, Wang W, Liang C
Biochemical and biophysical research communications 2025 Oct 10;784:152579
Biochemical and biophysical research communications 2025 Oct 10;784:152579
NEK7 mediates ESRD-associated endothelial injury by activating the NLRP3 inflammasome.
Sun L, Ren Y, Zhu W, Ni T, Huang S, Zhang A, Zhang Y, Hua H, Jia Z, Sun Z
International immunopharmacology 2025 Oct 10;163:115236
International immunopharmacology 2025 Oct 10;163:115236
Actomyosin forces trigger a conformational change in desmoplakin within desmosomes.
Dong Y, Elgerbi A, Xie B, Han Y, Kwiatkowski AV, Choy JS, Sivasankar S
Nature communications 2025 Oct 10;16(1):9052
Nature communications 2025 Oct 10;16(1):9052
Suppressor of Tumorigenicity 14 inhibits non-small cell lung cancer cell proliferation by suppressing Transketolase O-GlcNAcylation.
Ji L, Zhang M, Liu Y, Zhang H, Luo T, Zhao L, Zhang W, Chen B, Chen R
Experimental cell research 2025 Oct 1;452(2):114776
Experimental cell research 2025 Oct 1;452(2):114776
Mitochondrial DNA-driven senescence-associated secretory phenotype promotes the development of bronchopulmonary dysplasia.
Meng Y, Shi H, Xu H, Sun Y, Wang X, Wang R, Zhang Y
American journal of physiology. Cell physiology 2025 Oct 1;329(4):C1332-C1342
American journal of physiology. Cell physiology 2025 Oct 1;329(4):C1332-C1342
KPNA2 silencing sensitizes triple-negative breast cancer to chemotherapy by promoting multipolar division and suppressing DNA damage repair.
Cai Y, Du J, Wang H, Shen L, Xu Z, Zhaoxiong Y, Gong Z, Zhu Y, Wu C, Cai J, Zhang P, Chen S, Dai Z, Huang R, Zhu W
Oncogene 2025 Nov;44(44):4254-4270
Oncogene 2025 Nov;44(44):4254-4270
FTDC1/2, oocyte-specific cofactors of DNMT1 required for epigenetic regulation and embryonic development.
Li C, Li J, Du S, Ma Y, Guo Y, Zhang X, Wang B, Zhu S, An H, Chen M, Guo J, Han L, Ge J, Qian X, Schedl T, Guo X, Wang Q
Cell death and differentiation 2025 Nov;32(11):2093-2110
Cell death and differentiation 2025 Nov;32(11):2093-2110
CHIP/STUB1 suppresses the transcription and latent reactivation of HIV-1 via the TRAF6-NF-κB-HIV-LTR axis.
Zheng WH, Lin SY, He ZL, Ni RZ, Mu D
PLoS pathogens 2025 Nov;21(11):e1013683
PLoS pathogens 2025 Nov;21(11):e1013683
Obacunone ameliorates high-fat diet-induced MAFLD by regulating the PPARγ-FABP1/CD36 axis and the gut-liver crosstalk.
Wang X, Hong J, Liang R, Bao S, Li L, Wang J, Feng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157180
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157180
CERKL Reduced PI3P/Autophagy to Promote Pancreatic Cancer.
Zeng W, Yang Y, Li W, Pan J, Huang B, Zhang P, Xiao J
Cancer medicine 2025 Nov;14(22):e71402
Cancer medicine 2025 Nov;14(22):e71402
Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia-Induced Stress Granule Formation.
Li C, Liu Z, Zhu L, Wu G, Fu C, Li H, He T, Shen M, Liu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04896
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04896
Glabridin-Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity.
Wang Z, Wang M, Chen Q, Wang M, Li F, Lv L, Wen Z, Xu Z, Yang Y, Bi C, Liu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04729
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04729
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling.
Chamma H, Guha S, Eloiflin RJ, Augereau A, Le Hars P, Schüssler M, Messaoud-Nacer Y, Salma M, McKellar J, Re J, Chemarin M, Carrier A, Disyak MA, Taffoni C, Charpentier R, Husson Z, Valjent E, Andrieu-Soler C, Soler E, Christensen MH, Paludan SR, Schmidt FI, Tropea D, Majzoub K, Vila IK, Laguette N
Nature communications 2025 Nov 7;16(1):9827
Nature communications 2025 Nov 7;16(1):9827
FPR1-dependent Pro-inflammatory Ccl4(high) monocytes/macrophages drive and predict sepsis-induced acute lung injury.
Li Y, Shi J, Yu T, Piao M, Tan J, Miao Y, Gong L, Dong S, Li X, Liu H, Yu J, Zhang Y, Zhang Q
Respiratory research 2025 Nov 5;26(1):308
Respiratory research 2025 Nov 5;26(1):308
Structural insights into antagonist recognition by the vasopressin V2 receptor.
Zhang T, Liu H, You C, Zhang Y, Xu Y, Pan B, Wu C, Jin S, Yin YL, Wu K, Chen Y, Sun H, Si Y, Tan Y, Yin W, Xu HE, Guo D, Jiang Y
Nature communications 2025 Nov 4;16(1):9734
Nature communications 2025 Nov 4;16(1):9734
Microglial Nrf2 Functions as a Cell-Autonomous Regulator of Neuroinflammation and Trained Immunity in the Aging Brain.
Paraiso HC, Yen JJ, Scofield BA, Kuo PC, Chang FL, Yu II
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71244
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71244
Cell-type-specific dysregulation of mitochondrial calcium signaling in Alzheimer's disease.
Shukla S, Kadam AA, Goyani S, Jaiswal N, Samantaray K, Raghav D, Kashyap S, Tomar D, Jadiya P
Cell communication and signaling : CCS 2025 Nov 3;23(1):472
Cell communication and signaling : CCS 2025 Nov 3;23(1):472
Targeting Cathepsin B-mediated pyroptosis in fibroblasts alleviate ultraviolet-induced skin inflammation and injury.
Yao Z, Lu L, Yu M, Wang H, Shi Y, Ying J, Yu X, Xu Q, Zhang Z, Zhang S, Li Y, Wu Y, Zhu H, Jiang H
Cell communication and signaling : CCS 2025 Nov 28;24(1):97
Cell communication and signaling : CCS 2025 Nov 28;24(1):97
FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation.
Zhu J, Bao L, Xu S, Ji X
Science advances 2025 Nov 28;11(48):eadz2345
Science advances 2025 Nov 28;11(48):eadz2345
tiRNA: An efficient and controllable gene silencing technology via translation inhibition.
Xia B, Cai J, He Z, Zhu Q
New biotechnology 2025 Nov 25;89:177-190
New biotechnology 2025 Nov 25;89:177-190
Identification of ATG7 as a protein ATG8ylation substrate.
Xie H, Long J, Huang Y, Wang Y, Liu P, Li M
Cell reports 2025 Nov 25;44(11):116485
Cell reports 2025 Nov 25;44(11):116485
SOS1 inhibition suppresses the emergence of osimertinib resistance to generate a durable response in EGFR-mutant lung cancer.
Daley BR, Theard PL, Hughes JM, Finniff BA, Hofmann MH, Kostyrko K, Schenk RL, Vieira HM, Askew JW, Lewis RE, Kortum RL
Science signaling 2025 Nov 25;18(914):eaea2788
Science signaling 2025 Nov 25;18(914):eaea2788
Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
Riillo C, Parafati M, Crupi F, Fotschki B, Ragusa M, Di Vito A, Mignogna C, Mollace V, Janda E
Nutrients 2025 Nov 25;17(23)
Nutrients 2025 Nov 25;17(23)
Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells.
Yu T, Wang Y, Wang K, Fang Z, Zhu H, Zhang X, Li Y, Ye M
Nature communications 2025 Nov 25;16(1):10475
Nature communications 2025 Nov 25;16(1):10475
Spermidine enhances macrophages anti-inflammatory and regenerative functions by improving mitochondrial fitness.
Liu R, Cao L, Zhou Y, Li Y, Wang T, Meng Z, Yang T, Feng C, Yang Q, Liu X, Chen Y, Agostini M, Li P, Melino G, Wang Y, Shao C, Shi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157349
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157349
LRP12 promotes gastric cancer progression through AKT/mTOR signaling and M2 macrophage-mediated immunosuppression.
Wang Y, Yin X, Wang M, Zhu M, Xue Y
Scientific reports 2025 Nov 23;15(1):45183
Scientific reports 2025 Nov 23;15(1):45183
MRAP mediated adipocyte differentiation by thymic mesenchymal stromal cells contributes to thymic involution.
Wang D, Fang X, Deng Y, Wen X, Liu O, Xu J, Fan F, Wang D, Han Y, Zanvit P, Park SA, Jin W, Hu H, Sun L, Chen W
Nature communications 2025 Nov 20;16(1):10210
Nature communications 2025 Nov 20;16(1):10210
Curcumin Analogues Trigger HMOX1-Mediated Ferroptosis to Halt Endometrial Cancer Growth.
Wu X, Padilla JL, Smith LE, Goodla L, Leslie KK, Xue X
bioRxiv : the preprint server for biology 2025 Nov 19;
bioRxiv : the preprint server for biology 2025 Nov 19;
Nicotine Improves Memory Impairment in Aged Rats Through Enhanced Mitochondrial Homeostasis.
Ni Z, Li Y, Wang G, Wang S, Chen H, Hou H, Hu Q
Molecular neurobiology 2025 Nov 14;63(1):38
Molecular neurobiology 2025 Nov 14;63(1):38
The VCPKMT-VCP-HDAC1 axis inhibits colorectal cancer by conferring sensitivity to ferroptosis.
Huang C, Lin J, Xu S, Lv Y, Chen J, Cao J, Xie D, Wang F
Cancer cell international 2025 Nov 14;25(1):404
Cancer cell international 2025 Nov 14;25(1):404
Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer.
Li SY, Wang XY, Wang J, Cao JH, Lv YR, Xie D, Wang FW
Journal of translational medicine 2025 Nov 10;23(1):1252
Journal of translational medicine 2025 Nov 10;23(1):1252
SARS-CoV-2 ORF7a activates the endothelium to release von Willebrand factor that promotes thrombosis.
Zhang Q, Huang X, Lee H, Lee JG, Liu S, Limbu S, Basu MK, van de Leemput J, D'Agnillo F, Han Z, Zheng XL
Research and practice in thrombosis and haemostasis 2025 May;9(4):102947
Research and practice in thrombosis and haemostasis 2025 May;9(4):102947
Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage-Dependent Anion Channel 1-Mediated Mitochondrial Dysfunction.
Chen T, Zhang Y, Ding L, Xiong C, Mei C, Wei S, Jiang M, Huang Y, Chen J, Xie T, Zhu Q, Zhang Q, Huang X, Chen S, Li Y
MedComm 2025 May;6(5):e70149
MedComm 2025 May;6(5):e70149
Dendrimer nanocarriers for targeted co-delivery of MiR-146b-3p and 5-ALA to synergistic photodynamic therapy in secondary hyperparathyroidism.
Wen Y, Zou Z, Li Y, Zhang D, Liu Z, Liu H, Li X, Wu W, Zeng L, Zou Q, Yi W
International journal of biological macromolecules 2025 May;310(Pt 1):143307
International journal of biological macromolecules 2025 May;310(Pt 1):143307
Histone acetyltransferase BmMOF inhibits the proliferation of the Bombyx mori nucleopolyhedrovirus by targeting Bmp53.
Miao M, Bai SM, Huang YY, Zhang JW, Xu KL, Chen Y, Qian QT, Dong J, Nie HM, Mei J, Tong FD, Yu W
International journal of biological macromolecules 2025 May;305(Pt 2):141186
International journal of biological macromolecules 2025 May;305(Pt 2):141186
Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma.
Liu Y, Wang Q, Li Q, Ren P
Oncology letters 2025 May;29(5):250
Oncology letters 2025 May;29(5):250
Formosanin C inhibits triple-negative breast cancer progression by suppressing the phosphorylation of STAT3 and the polarization of M2 macrophages.
Dai YW, Wu ZX, Cheng Y, Wu HD, Chen JW, Lv LX, Wang ZQ, Li HF, Yan CZ, Bao JX, Liu CH, Dai XX
Breast cancer research and treatment 2025 May;211(1):71-89
Breast cancer research and treatment 2025 May;211(1):71-89
The involvement of thioredoxin reductase genes in development, reproduction and deltamethrin tolerance in the red flour beetle, Tribolium castaneum.
Ji C, Guan D, Chen H, Luo Z, Jian C, Wang Z, Ge H, Qian K, Wang J
Pesticide biochemistry and physiology 2025 May;210:106390
Pesticide biochemistry and physiology 2025 May;210:106390
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia.
Zhang FR, Tang J, Lai Y, Mo SQ, Lin ZM, Lei QQ, Han CC, Zhou AD, Lv XF, Wang C, Ou JS, Zhou JG, Pang RP
British journal of pharmacology 2025 May;182(9):2031-2048
British journal of pharmacology 2025 May;182(9):2031-2048
ERK pathway reactivation prevents anthrax toxin lethality in mice.
Liu J, Zuo Z, Ewing M, Cao Q, Cao L, Li Q, Finkel T, Leppla SH, Liu S
Nature microbiology 2025 May;10(5):1145-1155
Nature microbiology 2025 May;10(5):1145-1155
Serum-free endothelial cell culture medium for vascular smooth muscle cells sheet formation.
Yang J, Sun X, Jiang H, Li J, Liang J, Lin Z
Journal of biological engineering 2025 May 28;19(1):51
Journal of biological engineering 2025 May 28;19(1):51
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Lin J, Yin Y, Cao J, Zhang Y, Chen J, Chen R, Zou B, Huang C, Lv Y, Xu S, Yang H, Lin P, Xie D
Cell discovery 2025 May 28;11(1):52
Cell discovery 2025 May 28;11(1):52
Mechanobiological mechanism of cyclic stretch-induced cell columnarization.
Lee LW, Lee GH, Su IH, Lu CH, Lin KH, Wen FL, Tang MJ
Cell reports 2025 May 27;44(5):115662
Cell reports 2025 May 27;44(5):115662
Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes.
Tian C, Sun L, Liu K, Fu L, Zhang Y, Chen W, He F, Yang J
Nature communications 2025 May 26;16(1):4863
Nature communications 2025 May 26;16(1):4863
MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1.
Yang Y, Ma Y, Fan S, Zhu J, Ye B, Zhang R, Li J, Li H, Zheng Z, Li Y, Lv L
Cell death discovery 2025 May 26;11(1):253
Cell death discovery 2025 May 26;11(1):253
Aberrant downregulation of Y-box binding protein 1 expression impairs the cell cycle in an m(5)C-dependent manner in human granulosa cells from patients with primary ovarian insufficiency.
Chen Q, Wang S, Zhang M, Xiang Y, Chen Q, Li Z, Song Y, Bai L, Zhu Y
Cellular and molecular life sciences : CMLS 2025 May 21;82(1):206
Cellular and molecular life sciences : CMLS 2025 May 21;82(1):206
Selenoprotein K Confers Protection against Iron Dyshomeostasis-Related Neurotoxicity by Regulating the Palmitoylation of TfR-1.
Jia SZ, Li Y, Xu XW, Huang YP, Deng XY, Zhang ZH, Song GL
Journal of agricultural and food chemistry 2025 May 21;73(20):12233-12246
Journal of agricultural and food chemistry 2025 May 21;73(20):12233-12246
Liquiritigenin protects against cadmium-induced testis damage in mice by inhibiting apoptosis and activating androgen receptor.
Yuan S, Guo J, Yang B, Huang AX, Hu S, Li Y, Chen J, Yuan B, Yang J
Biochemical and biophysical research communications 2025 May 20;759:151642
Biochemical and biophysical research communications 2025 May 20;759:151642
PRMT1-catalyzed NUSAP1 methylation enhances Notch2 signaling and 5-FU resistance in gastric cancer.
Jiang S, Li G, Peng S, Chen S, Pang Y, Cui H, Wang F
Cell death & disease 2025 May 20;16(1):404
Cell death & disease 2025 May 20;16(1):404
ML210 Antagonizes ABCB1- Not ABCG2-Mediated Multidrug Resistance in Colorectal Cancer.
Li YC, Xiong YM, Long ZP, Huang YP, Shu YB, He K, Sun HY, Shi Z
Biomedicines 2025 May 20;13(5)
Biomedicines 2025 May 20;13(5)
Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression.
Jolly JT, Al-Hamaly MA, Smith CN, Spielmann HP, Blackburn JS
bioRxiv : the preprint server for biology 2025 May 18;
bioRxiv : the preprint server for biology 2025 May 18;
Benzbromarone interferes with the interaction between Hsp90 and Aha1 by interacting with both of them.
Zhong Y, Shi L, Xu Z, Gao J, Ma Q, Gao T, Tang J, Xiong M, Xu Y, Dai H, Zhou H, Zhang N, Zhou C
Communications biology 2025 May 16;8(1):761
Communications biology 2025 May 16;8(1):761
Prkra dimer senses double-stranded RNAs to dictate global translation efficiency.
Lu T, Ma P, Fang H, Chen A, Xu J, Kuang X, Wang M, Su L, Wang S, Zhang Y, Wang J, Yang B, Shi DL, Zhou Y, Gong Q, Liu X, Mao B, Shao M
Molecular cell 2025 May 15;85(10):2032-2047.e9
Molecular cell 2025 May 15;85(10):2032-2047.e9
De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma.
Teisseire M, Sahu U, Parola J, Tsai MC, Vial V, Durivault J, Grépin R, Cormerais Y, Molina C, Gouraud A, Pagès G, Ben-Sahra I, Giuliano S
Cancer research 2025 May 15;85(10):1857-1873
Cancer research 2025 May 15;85(10):1857-1873
Functional characterization of a novel protein-coding circular RNA, circRNA_1193, from the mAAP gene in silkworm and its role in antiviral defense against BmCPV.
Li S, Shen Z, Zhao H, Chen X, Qiu Q, Tong X, Zhu M, Zhang X, Gong C, Hu X
mBio 2025 May 14;16(5):e0012525
mBio 2025 May 14;16(5):e0012525
Effects of Ninjin'yoeito and physical exercise on serum corticosterone and hippocampal BDNF/proBDNF and neuroinflammation in post-stroke depression in rats.
Sakakima H, Nojima N, Tani A, Nakanishi K, Matsuoka T, Matsuzaki R, Kakimoto S, Kato Y, Tachibe Y, Inadome M, Kawatani T, Otsuka S, Mizuno K, Maruyama I
BMC complementary medicine and therapies 2025 May 13;25(1):171
BMC complementary medicine and therapies 2025 May 13;25(1):171
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Yang ZH, Wu P, Zhang BX, Yang CR, Huang J, Wu L, Guo SH, Zhou Y, Mao Y, Yin Y, Wu X, Cheng P, Li B, Zhou R, Shen HM, Nie S, Cai ZY, Mo W
Molecular cell 2025 May 1;85(9):1775-1789.e5
Molecular cell 2025 May 1;85(9):1775-1789.e5
Sex hormone-binding globulin dampens growth and metastasis of breast cancer in an estrogen-independent manner.
Lee SR, Kim NR, Mukae M, Won YS, Hong EJ
American journal of physiology. Cell physiology 2025 May 1;328(5):C1685-C1698
American journal of physiology. Cell physiology 2025 May 1;328(5):C1685-C1698
Diurnal Variation in Melatonin-Mediated Cardiac Protection via Per2 Expression in Heart.
Luo R, Yang Z, Liang W, Chen Y, Jie Y, Zhang Y, Li L
Journal of pineal research 2025 Mar;77(2):e70036
Journal of pineal research 2025 Mar;77(2):e70036
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation.
Xiao D, Ran H, Chen L, Li Y, Cai Y, Zhang S, Qi Q, Wu H, Zhang C, Cao S, Mi L, Huang H, Qi J, Han Q, Tu H, Li H, Zhou T, Li F, Li A, Man J
Science China. Life sciences 2025 Mar;68(3):673-688
Science China. Life sciences 2025 Mar;68(3):673-688
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.
Zuo X, Zhao R, Wu M, Wang Y, Wang S, Tang K, Wang Y, Chen J, Yan X, Cao Y, Li T
Nature aging 2025 Mar;5(3):419-436
Nature aging 2025 Mar;5(3):419-436
Identification of chemical inhibitors targeting long noncoding RNA through gene signature-based high throughput screening.
An J, Wang H, Wei M, Yu X, Liao Y, Tan X, Hu C, Li S, Luo Y, Gui Y, Lin K, Wang Y, Huang L, Wang D
International journal of biological macromolecules 2025 Mar;292:139119
International journal of biological macromolecules 2025 Mar;292:139119
DSTYK phosphorylates STING at late endosomes to promote STING signaling.
Dong H, Zhang H, Song P, Hu Y, Chen D
EMBO reports 2025 Mar;26(6):1620-1646
EMBO reports 2025 Mar;26(6):1620-1646
The natural product micheliolide promotes the nuclear translocation of GAPDH via binding to Cys247 and induces glioblastoma cell death in combination with temozolomide.
Guo JS, Wang JY, Chen SH, Deng YP, Gao QY, Liu ZX, Liu J, Lv K, Liu N, Bai GY, Shan CL, Feng XQ, Li J
Biochemical pharmacology 2025 Mar;233:116759
Biochemical pharmacology 2025 Mar;233:116759
HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis.
Kuang C, Shi H, Cao J, Zhou Y, Zhang H, Wang Y, Zhou J
PLoS neglected tropical diseases 2025 Mar;19(3):e0012877
PLoS neglected tropical diseases 2025 Mar;19(3):e0012877
The NLRP3 activation-related signature predicts the diagnosis and indicates immune characteristics in endometriosis.
Nong W, Wei H, Dou S, He L, Lin L, Lu D, Wei B, Zhang S, Huo P, Dong M
Journal of reproductive immunology 2025 Mar;168:104443
Journal of reproductive immunology 2025 Mar;168:104443
HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism.
Bian R, Shang Y, Xu N, Liu B, Ma Y, Li H, Chen J, Yao Q
Cellular signalling 2025 Mar;127:111583
Cellular signalling 2025 Mar;127:111583
The polarization of macrophages participates in the repair after folic acid-induced acute kidney injury.
Yang S, Shen Y
Cellular immunology 2025 Mar-Apr;409-410:104929
Cellular immunology 2025 Mar-Apr;409-410:104929
NUB1 reduction promotes PCNA-mediated tumor growth by disturbing the PCNA polyubiquitination/NEDDylation in hepatocellular carcinoma cells.
Du D, Zhang W, Zhang D, Liu L, Li J, Chen Z, Yu X, Ye M, Wang W, Li Z, Shao J
Cell death & disease 2025 Mar 31;16(1):228
Cell death & disease 2025 Mar 31;16(1):228
Development of Novel Peptide-Based Radiotracers for Detecting FGL1 Expression in Tumors.
Xu Y, Zhang J, Pan D, Yan J, Chen C, Wang L, Wang X, Yang M, Xu Y
Molecular pharmaceutics 2025 Mar 3;22(3):1605-1614
Molecular pharmaceutics 2025 Mar 3;22(3):1605-1614
Bio-SS-TS as a Targeted Antitumor Drug Exerts an Anti-Liver Cancer Effect by Enhancing Mitochondria-Dependent Apoptosis.
Li J, Qin Y, Li M, Shang J, Chen H, Liu Y, Liu B, Zhou P, Zhao T, Wang G, Ge C, Zhang Y, Jia H, Ren F
Biological procedures online 2025 Mar 28;27(1):11
Biological procedures online 2025 Mar 28;27(1):11
Perturbed cell fate decision by schizophrenia-associated AS3MT(d2d3) isoform during corticogenesis.
Kim S, Woo Y, Um D, Chun I, Noh SJ, Ji HA, Jung N, Goo BS, Yoo JY, Mun DJ, Nghi TD, Nhung TTM, Han SH, Lee SB, Lee W, Yun J, So KH, Kim DK, Jang H, Suh Y, Rah JC, Baek ST, Yoon KJ, Kim MS, Kim TK, Park SK
Science advances 2025 Mar 28;11(13):eadp8271
Science advances 2025 Mar 28;11(13):eadp8271
Role of declined electrogenic Na(+)/HCO(3)(-) cotransporter NBCe1 in mucus barrier impairment and colonic inflammation.
He J, Wu J, Tan J, Yang P, Bai T, Song J, Hou X, Zhang L
International immunopharmacology 2025 Mar 26;150:114282
International immunopharmacology 2025 Mar 26;150:114282
ACLY inhibitor reduced Porphyromonas gingivalis-induced pyroptosis by suppressing microtubules acetylation in macrophages.
Mao H, Guo F, Wang C, Jiang K, Li H, Lei L
International immunopharmacology 2025 Mar 26;150:114249
International immunopharmacology 2025 Mar 26;150:114249
Compositionally unique mitochondria in filopodia support cellular migration.
Marlar-Pavey M, Tapias-Gomez D, Mettlen M, Friedman JR
Current biology : CB 2025 Mar 24;35(6):1227-1241.e6
Current biology : CB 2025 Mar 24;35(6):1227-1241.e6
ATP8A1-translocated endosomal phosphatidylserine fine-tunes the multivesicular body formation and the endo-lysosomal traffic.
Lan Z, Tian Y, Li C, Wang Y, Yi P, Zhang R
iScience 2025 Mar 21;28(3):111973
iScience 2025 Mar 21;28(3):111973
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Fang X, Zhong Y, Zheng R, Wu Q, Liu Y, Zhang D, Wang Y, Ding W, Wang K, Zhong F, Lin K, Yao X, Hu Q, Li X, Xu G, Liu N, Nie J, Li D, Geng H, Guan Y
Science advances 2025 Mar 21;11(12):eadr8648
Science advances 2025 Mar 21;11(12):eadr8648
Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice.
Wang N, Zhang S, Langfelder P, Ramanathan L, Gao F, Plascencia M, Vaca R, Gu X, Deng L, Dionisio LE, Vu H, Maciejewski E, Ernst J, Prasad BC, Vogt TF, Horvath S, Aaronson JS, Rosinski J, Yang XW
Cell 2025 Mar 20;188(6):1524-1544.e22
Cell 2025 Mar 20;188(6):1524-1544.e22
The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation.
Zhang L, Wang J, Tang Z, Lin Z, Su R, Hu N, Tang Y, Ge G, Fan J, Tong MH, Xue Y, Zhou Y, Cheng H
Nature communications 2025 Mar 17;16(1):2605
Nature communications 2025 Mar 17;16(1):2605
Integrated Multiomics Analyses Reveal Molecular Insights into How Intermittent Fasting Ameliorates Obesity and Increases Fertility in Male Mice.
Zhang S, Lin T, Bao Y, She J, Liu X, Hu J, Peng A, Liu X, Huang H
Nutrients 2025 Mar 14;17(6)
Nutrients 2025 Mar 14;17(6)
Huachansu suppresses colorectal cancer via inhibiting PI3K/AKT and glycolysis signaling pathways: Systems biology and network pharmacology.
Yang H, Chen Y, Dai C, Xing Y, Qiu Z, Zhao J, Ye J, Yu C, Lin P, Zhang W, Zhang L, Luan X
Journal of ethnopharmacology 2025 Mar 13;343:119479
Journal of ethnopharmacology 2025 Mar 13;343:119479
Blueberry Anthocyanin Extracts (BAEs) Protect Retinal and Retinal Pigment Epithelium Function from High-Glucose-Induced Apoptosis by Activating GLP-1R/Akt Signaling.
Li R, Du S, Ye Z, Yang W, Liu Y
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5886-5898
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5886-5898
Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC.
Gao Q, Hofer FW, Filbeck S, Vermeulen BJA, Würtz M, Neuner A, Kaplan C, Zezlina M, Sala C, Shin H, Gruss OJ, Schiebel E, Pfeffer S
Nature communications 2025 Mar 12;16(1):2453
Nature communications 2025 Mar 12;16(1):2453
Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer.
Cai J, Liu Z, Chen S, Zhang J, Li H, Wang X, Yang F, Wang S, Li X, Li Y, Chen K, Wang J, Sun M, Qiu M
Experimental hematology & oncology 2025 Mar 12;14(1):35
Experimental hematology & oncology 2025 Mar 12;14(1):35
Inhibition of Bif-1 confers cardio-protection in myocardial infarction.
Xu Y, Zheng Z, Jiang X, Wang X, Xu Q, Lu X, Huang Y, Qin Y, Hou N, Liu Y
American journal of physiology. Cell physiology 2025 Mar 1;328(3):C1076-C1089
American journal of physiology. Cell physiology 2025 Mar 1;328(3):C1076-C1089
FOXM1, a super enhancer-associated gene, is related to poorer prognosis and gemcitabine resistance in pancreatic cancer.
Jiang J, Shen T, Chen D, Dai Z, Wang X, Meng Q, Yang Z, Zhang D, Guo X, Xu J, Gu J, Wang C
Cell biochemistry and biophysics 2025 Jun;83(2):2441-2452
Cell biochemistry and biophysics 2025 Jun;83(2):2441-2452
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion.
Jhanji M, Bhan A, Arrowood C, Yakout DW, Shroff A, McManus D, Gifford H, Vacharasin J, Lizarraga SB, Nazarko TY, Mabb AM, Sajish M
IUBMB life 2025 Jun;77(6):e70030
IUBMB life 2025 Jun;77(6):e70030
Irisin reverses high-fat diet-induced metabolic dysfunction via activation of brown adipose tissue in mice.
Dai J, Zhao Y, Chen Y, Jiang Y, Sun R, Tang X, Cui Y, Mao H, Peng XG
International journal of obesity (2005) 2025 Jun;49(6):1066-1075
International journal of obesity (2005) 2025 Jun;49(6):1066-1075
A positive feedback loop of OTUD1 and c-Jun driven by leptin expedites stemness maintenance in ovarian cancer.
Wang J, Yang F, Chen Y, Xing Y, Huang J, Cao J, Xiong J, Liu Y, Zhao Q, Luo M, Xiong J, Fan G, Lyu Q, Li F, Zhang W
Oncogene 2025 Jun;44(22):1731-1745
Oncogene 2025 Jun;44(22):1731-1745
Activation of GPER1 alleviates white matter injury by promoting microglia M2 polarization through EGFR/Stat3 pathway in intracerebral hemorrhage mice.
Zhang X, Mao J, Li H, Zhang C, Ge H, Zhong J
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108315
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108315
The critical role of transcription factor GATA1 in erythrocyte proliferation and morphology in blood clam Anadara granosa.
Wang J, Zhang Y, Xu Y, Jin H, Yang C, Liu H, Bao Y
International journal of biological macromolecules 2025 Jun;315(Pt 2):144691
International journal of biological macromolecules 2025 Jun;315(Pt 2):144691
Ubiquitin-specific protease 21 aggravates enterovirus 71 (EV71) infection by restricting Lys48-linked ubiquitination of EV71-2A protease.
Yang X, Tang M, Zang L, Hao P, Chen Y, Yuan Y, Miao Y, Zuo Y, Wu Z, Che Z, Ren T, Wu Q, Peng Y, Zhou W, Zheng H, Shi W
International journal of biological macromolecules 2025 Jun;314:144202
International journal of biological macromolecules 2025 Jun;314:144202
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.
Zhou Y, Chen W, Feng S, Liu S, Chen C, Yao B, Shen XL
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1440-1452
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1440-1452
Reproductive-Triggered Sterol Competition Exacerbates Age-Related Intestinal Barrier Damage in Drosophila Females.
Yu G, Chen K, Yang M, Wu Q
Aging cell 2025 Jun;24(6):e70011
Aging cell 2025 Jun;24(6):e70011
Doxorubicin-induced senescence is modulated by the eukaryotic release factor 3a and its polyglycine expansion in HCT116 cells.
Jolles B, Stierlé V
Biochimie 2025 Jun;233:81-87
Biochimie 2025 Jun;233:81-87
Curcumin modulates β-catenin stabilization via targeting proteasomal deubiquitinating enzyme USP14(☆).
Shen M, Chen L, Jiang J, Wang Z, Gong Q, Zhang X, Ke X, Qu Y
Pharmacological research 2025 Jun;216:107745
Pharmacological research 2025 Jun;216:107745
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L, Gao P, Zhang H
Nature chemical biology 2025 Jun;21(6):926-938
Nature chemical biology 2025 Jun;21(6):926-938
rTMS ameliorates CUMS-induced anxiety-depression-like behaviour and cognitive dysfunction in rats by modulating the COX-2/PGE2 signalling pathway.
Pei Y, Liu H, Lang J, Chen Y, Zhang F, Hao R, Li J, Gu S, Peng Q, Song J, Zhang Z
Journal of psychiatric research 2025 Jun;186:116-128
Journal of psychiatric research 2025 Jun;186:116-128
Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS-PAGE with low acrylamide concentration.
Emmanuel N, He Q, Kang Y, Zhang D, Gao M, Wang M, Fan K, Xiong J, Wu S, Fa B, Xiao Z, Niu Y, Yao J, Zhang Y
FEBS open bio 2025 Jun;15(6):994-1008
FEBS open bio 2025 Jun;15(6):994-1008
Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN-m5f cells.
Wang M, Tan J, He X, Chen Y, Qiu G, Yang M
FEBS open bio 2025 Jun;15(6):972-984
FEBS open bio 2025 Jun;15(6):972-984
Establishment and biological characterization of radioresistant colorectal cancer cell lines.
Qu TY, Dai Q, Leng J, Fang L, Ma JJ, Chen R, Chen C, Ran PF, Zhou WW, Liu C, Yu HF
FEBS open bio 2025 Jun;15(6):1009-1021
FEBS open bio 2025 Jun;15(6):1009-1021
Chromosomal integrity of freeze-dried karyoplasts in mice.
Kusakabe H
Cryobiology 2025 Jun;119:105247
Cryobiology 2025 Jun;119:105247
Dual-omics analysis of transcriptome and translatome unveils lycopene-induced triglyceride accumulation mechanisms in muscle cells.
Liu S, Luo Z, Huang T, Liu S, Li Y, Zhou L
Biochemical and biophysical research communications 2025 Jun 8;765:151878
Biochemical and biophysical research communications 2025 Jun 8;765:151878
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
Feng X, Tian Y, Guo X, Lei JH, Yu J, Zheng C, Chen M, Ding RB, Kwok HF, Luo S, Bao J
Biomolecules 2025 Jun 8;15(6)
Biomolecules 2025 Jun 8;15(6)
Can linc00968 Regulate SH-SY5Y Cell Apoptosis Induced by Amyloid beta Neurotoxicity?
Kurt S, Karagur ER, Kavak DE, Kizildag S
Molecular biology reports 2025 Jun 6;52(1):557
Molecular biology reports 2025 Jun 6;52(1):557
Clearance of protein aggregates during cell division.
Du S, Wang Y, Chen B, Xie S, Chan KY, Hay DC, Chew TG
eLife 2025 Jun 6;13
eLife 2025 Jun 6;13
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL.
Zhang X, Zhang J, Wang C
Journal of ovarian research 2025 Jun 5;18(1):122
Journal of ovarian research 2025 Jun 5;18(1):122
Transcription factors FOXN1 and intrathymic cytokines contribute to dysfunction of TECs during lipopolysaccharide-induced thymic atrophy.
Liu Y, Zhao C, Cui L, Chen Y, Peng H, Liu J, Liu Z, Song Y
International immunopharmacology 2025 Jun 5;157:114791
International immunopharmacology 2025 Jun 5;157:114791
Sodium Benzoate Inhibits Osteoblast Differentiation and Accelerates Bone Loss by Regulating the FGF2/p38/RUNX2 Pathway.
Wang Z, Wang Y, Tang Y, Guo X, Gao Q, Shao Y, Wang J, Tian R, Shi Y
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13891-13901
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13891-13901
Txnip/Trx Is a Potential Element in Regulating O-GlcNAc Modification in Photoreceptors to Alleviate Diabetic Retinopathy.
Imdad L, Xu S, Meng Y, Bao K, Dong W, Yin X, Tong Y, Zhang W, Ren X, Kong L
International journal of molecular sciences 2025 Jun 4;26(11)
International journal of molecular sciences 2025 Jun 4;26(11)
HELQ Maintains Genome Stability of Primordial Germ Cells by Inhibiting LINE-1 Expression.
Cao L, Ren J, Kong Z, Hu M, Zhang Y, Chen ZJ, Qin Y, Yang Y, Zhao S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70720
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70720
GCRV-II Triggers B and T Lymphocyte Apoptosis via Mitochondrial ROS Pathway.
Wang J, Dong WJ, Wu CS, Tian TT, Zhang XJ, Zhang YA
Viruses 2025 Jun 30;17(7)
Viruses 2025 Jun 30;17(7)
Oncometabolite fumarate facilitates PD-L1 expression and immune evasion in clear cell renal cell carcinoma.
Gao Y, Fan S, Sun X, Li J, Dai Y, Li H, Ma H, Xu Y, Lv L
Cell death & disease 2025 Jun 3;16(1):432
Cell death & disease 2025 Jun 3;16(1):432
HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes.
Li H, Zhang X, Liang X, Li S, Cui Z, Zhao X, Wang K, Zha B, Ma H, Xu M, Lv L, Xu Y
eLife 2025 Jun 3;13
eLife 2025 Jun 3;13
BST2 and DIRAS3 Drive Immune Evasion and Tumor Progression in High-Grade Glioma.
Liao Z, Wu S, Shi Z, Chen D, Chen J, Zhang H
International journal of molecular sciences 2025 Jun 27;26(13)
International journal of molecular sciences 2025 Jun 27;26(13)
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
Wu M, Wu X, Sun H, Wang W, Zhang L, Liu X, Zhang Y, Zhang X, Liu J, Shen B, Zhou T
Science advances 2025 Jun 27;11(26):eadq9643
Science advances 2025 Jun 27;11(26):eadq9643
Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Guo J, Tang H, Zhao W, Li Y, Song S, Feng F, Huang S, Wang X, Zhou Y, Pei J, Guo D, Xie H, Lu X
Journal of medicinal chemistry 2025 Jun 26;68(12):12862-12880
Journal of medicinal chemistry 2025 Jun 26;68(12):12862-12880
Shedding of GPP130 by PC7 and Furin: Potential Implication in Lung Cancer Progression.
Prabhala P, Duval S, Evagelidis A, Le Dévéhat M, Sachan V, Seidah NG
International journal of molecular sciences 2025 Jun 26;26(13)
International journal of molecular sciences 2025 Jun 26;26(13)
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.
Qu Y, Wang X, Li J, Luo H, Liu H, Wang T, Han X
International immunopharmacology 2025 Jun 26;159:114947
International immunopharmacology 2025 Jun 26;159:114947
SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes.
Huang XY, Yang D, Liu YZ, Zhang EX, Yang Q, Kang W, Zhang XO, Shi J, Song CQ
Cell reports 2025 Jun 24;44(6):115843
Cell reports 2025 Jun 24;44(6):115843
Hypoxia upregulates the expression of PD-L1 via NPM1 in breast cancer.
Yu Y, Sun R, Hu F, Ding Z, Li X, Han J, Liang L, Wang T, Xi G, Dong X, Li Y, Zhao X, Zhang D
Journal for immunotherapy of cancer 2025 Jun 23;13(6)
Journal for immunotherapy of cancer 2025 Jun 23;13(6)
Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain.
Moreno JF, You JS, Rodriguez CC, Pant S, Reyes-Ordoñez A, Abdullah R, Singh N, van der Donk MJ, Tajkhorshid E, Chen J
iScience 2025 Jun 20;28(6):112753
iScience 2025 Jun 20;28(6):112753
Ancestry-linked stromal variations impact breast epithelial cell invasion.
Schmidtmann MG, Elliott V, Clancy JW, Schafer ZT, Nakshatri H, D'Souza-Schorey C
iScience 2025 Jun 20;28(6):112686
iScience 2025 Jun 20;28(6):112686
Birth of protein-coding exons by ancient domestication of LINE-1 retrotransposon.
Kitao K, Ichiyanagi K, Nakagawa S
Genome research 2025 Jun 2;35(6):1287-1300
Genome research 2025 Jun 2;35(6):1287-1300
WISP2/CCN5 revealed as a potential diagnostic biomarker for endometriosis based on machine learning and single-cell transcriptomic analysis.
Dou S, Ling S, Nong W, Wei B, Huang Y, Li G, Wang R, Qin H
Functional & integrative genomics 2025 Jun 19;25(1):131
Functional & integrative genomics 2025 Jun 19;25(1):131
ANP32 proteins from ticks and vertebrates are key host factors for replication of Bourbon virus across species.
Zhang Z, Aziati ID, Nipper T, Boon ACM, Mehle A
Journal of virology 2025 Jun 17;99(6):e0052225
Journal of virology 2025 Jun 17;99(6):e0052225
YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formation.
Guo L, Duan X, Li J, Hao Z, Bi Y, Chen Y, Du X, Wu S
Journal of virology 2025 Jun 17;99(6):e0032025
Journal of virology 2025 Jun 17;99(6):e0032025
Neurotransmitter imbalance and amygdala synaptic plasticity in lumbar disc herniation-induced chronic pain and related emotional Disturbances:A multi-omics analysis.
Huang Z, Tan H, Fu Y, Xie H, Tan H, Gao K, Lou H
Neuropharmacology 2025 Jun 15;271:110405
Neuropharmacology 2025 Jun 15;271:110405
Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific.
Beckman WF, Parkinson LM, Chaytor L, Philpott A
Development (Cambridge, England) 2025 Jun 15;152(12)
Development (Cambridge, England) 2025 Jun 15;152(12)
Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model.
Gu J, Liu C, Li Y, Feng L, Geng M, Dong J, Han J, Zhao L, Shao Q, Wang HY, Wang CH
Behavioral and brain functions : BBF 2025 Jun 11;21(1):16
Behavioral and brain functions : BBF 2025 Jun 11;21(1):16
Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells.
Koppenhafer SL, Geary EL, Thomas MV, Croushore EE, Zimmerman JAO, Gedminas JM, Quelle DE, Dodd RD, Gordon DJ
Cancer research communications 2025 Jun 1;5(6):1034-1048
Cancer research communications 2025 Jun 1;5(6):1034-1048
Discovery of novel selective HDAC6 inhibitors via a scaffold hopping approach for the treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo.
Quan J, Ma C, Zhao X, Guo Y, Qu W, Zhou X, Ma E, Xu Y
Bioorganic chemistry 2025 Jun 1;159:108360
Bioorganic chemistry 2025 Jun 1;159:108360
Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells.
Asaka Y, Masumoto T, Uneda A, Chin VD, Otani Y, Peña T, Katayama H, Itano T, Ando T, Huang R, Fujimura A
The journal of physiological sciences : JPS 2025 Jul;75(2):100016
The journal of physiological sciences : JPS 2025 Jul;75(2):100016
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.
Qu Q, Chen Y, Wang Y, Wang W, Long S, Yang HY, Wu J, Li M, Tian X, Wei X, Liu YH, Xu S, Xiong J, Yang C, Wu Z, Huang X, Xie C, Wu Y, Xu Z, Zhang C, Zhang B, Feng JW, Chen J, Feng Y, Fang H, Lin L, Xie ZK, Sun B, Tian H, Yu Y, Piao HL, Xie XS, Deng X, Zhang CS, Lin SC
Nature 2025 Jul;643(8070):201-209
Nature 2025 Jul;643(8070):201-209
NEIL3 Deficiency Enhances HCC Cell Sensitivity to Oxaliplatin by Inhibiting the Fanconi Anaemia Pathway.
Wang J, Liao C, Luo J, Li M, Gu L, Li X, Chen L
Cell biology international 2025 Jul;49(7):824-835
Cell biology international 2025 Jul;49(7):824-835
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Xu F, Xia Q, Chen B, Wang R, Zhang J, Zhao X, Zhang Z, Yao Z, Zhang J, Zhou S, Li X, Chen B, Xu A, Wu L, Zhao G
Cell death and differentiation 2025 Jul;32(7):1303-1316
Cell death and differentiation 2025 Jul;32(7):1303-1316
CD36 promotes iron accumulation and dysfunction in CD8+ T cells via the p38-CEBPB-TfR1 axis in early-stage hepatocellular carcinoma.
Qin Y, Huo F, Feng Z, Hou J, Ding Y, Wang Q, Gui Y, Yang Z, Yang J, Zhou G, Li L, Jiang J, Kong L, Wang S, Nan G, Xu D, Xie X, Wang L, He Q, Yang R, Lin P, Bian H, Chen ZN, Wu J
Clinical and molecular hepatology 2025 Jul;31(3):960-980
Clinical and molecular hepatology 2025 Jul;31(3):960-980
Investigating shared diagnostic genes and mechanisms between metabolic syndrome and dry eye disease via integrated bioinformatics analysis and in vivo validation.
Liu Z, Li Y, Bao J, Tian L, Jie Y
Experimental eye research 2025 Jul;256:110374
Experimental eye research 2025 Jul;256:110374
Discovery of a novel BCL-2 inhibitor GW806742X for the treatment of TNBC.
Liu W, Xu J, Chen L, Zhang D, Zhang J, Lu L, Zhang X, Huang X, Zhang G
Biochemical pharmacology 2025 Jul;237:116925
Biochemical pharmacology 2025 Jul;237:116925
Boron neutron capture therapy with pteroyl-closo-dodecaborate-conjugated 4-(p-iodophenyl)butyric acid (PBC-IP) for a head and neck squamous cell carcinoma (SAS) model mice.
Miura K, Nishimura K, Suzuki M, Nakamura H
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2025 Jul;221:111837
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2025 Jul;221:111837
Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection.
Liu X, Zhao L, Liu D, Zhao L, Tuo Y, Peng Q, Huang F, Song Z, Niu C, He X, Xu Y, Wan J, Zhu P, Jian Z, Guo J, Liu Y, Lu J, Liang S, Zheng S
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3663-3684
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3663-3684
Aldolase A accelerates hepatocarcinogenesis by refactoring c-Jun transcription.
Yang X, Ma GY, Li XQ, Tang N, Sun Y, Hao XW, Wu KH, Wang YB, Tian W, Fan X, Li Z, Feng C, Chao X, Wang YF, Liu Y, Li D, Cao W
Journal of pharmaceutical analysis 2025 Jul;15(7):101169
Journal of pharmaceutical analysis 2025 Jul;15(7):101169
Refined qingkailing attenuates reactive astrocytes and glial scar formation after ischemia stroke via the EGFR/PLCγ pathway.
Ren ZL, Zhang CX, Zheng YX, Chen CA, Dan-Chen, Lan X, Yan X, Liu Y, He YH, Cheng JL, Han JH, Wang QG, Wang XQ, Cheng FF, Li CX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156696
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156696
ADAM Sheddase Activity Promotes the Detachment of Small Extracellular Vesicles From the Plasma Membrane.
Bizingre C, Arellano-Anaya Z, Picard F, Pietri M, Baudry A, Roussel F, Bianchi C, Alleaume-Butaux A, Ardila-Osorio H, Romao M, Lavieu G, Raposo G, Schneider B
Journal of extracellular vesicles 2025 Jul;14(7):e70114
Journal of extracellular vesicles 2025 Jul;14(7):e70114
Ultrasound-Guided Functionalized Extracellular Vesicles for Visualized, Controlled, and Efficient Renal Delivery for Enhanced Kidney Repair.
Chen Y, Sheng C, Xiao T, Jiang B, Xu X, Cui S, Shen W, Zheng X, Guo X, Chen X, Zhang C, Cai G
Advanced healthcare materials 2025 Jul;14(17):e2404719
Advanced healthcare materials 2025 Jul;14(17):e2404719
PP2Acα regulates sleep amount and sleep homeostasis in mice.
Zhou S, Shi B, Chen L, Yin X, Liu M, Wu C, Wang H, Wang X, Li B, Wang F, Li Q, Liu Q
Communications biology 2025 Jul 8;8(1):1018
Communications biology 2025 Jul 8;8(1):1018
Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling the immune microenvironment.
Huang SS, Chen W, Vaishnani DK, Huang LJ, Li JZ, Huang SR, Li YZ, Xie QP
World journal of gastroenterology 2025 Jul 7;31(25):107893
World journal of gastroenterology 2025 Jul 7;31(25):107893
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer.
Yu D, Hu H, Zhang Q, Wang C, Xu M, Xu H, Geng X, Cai M, Zhang H, Guo M, Lu D, Xu H, Li L, Zhang X, Shen R, Lin S, Wang Q, Zhang W, Liu S
Signal transduction and targeted therapy 2025 Jul 7;10(1):211
Signal transduction and targeted therapy 2025 Jul 7;10(1):211
The proximity proteome of pre-40S pre-ribosomal particle components PNO1 and NOB1 using turboID proximity labeling technology.
Xu X, Chen W, Zheng J, Liao JY, Yan H, Zhu S
Gene 2025 Jul 5;955:149411
Gene 2025 Jul 5;955:149411
Discovery of 3,4-dihydropyrimidine derivatives as novel Anti-PEDV agents targeting viral internalization through a unique calcium homeostasis disruption mechanism.
Lv S, Ma R, Tang Q, Wang X, Wang C, Zhang K, Li H, Ye W, Zhou W
European journal of medicinal chemistry 2025 Jul 5;291:117637
European journal of medicinal chemistry 2025 Jul 5;291:117637
The Effects of Different Types of Exercise on Pulmonary Inflammation and Fibrosis in Mice with Type 2 Diabetes Mellitus.
Gao H, Ma X, Wang Z, Zhu D, Guo Y, Zhao L, Xiao W
Cells 2025 Jul 4;14(13)
Cells 2025 Jul 4;14(13)
Loss of C-Terminal Coiled-Coil Domains in SDCCAG8 Impairs Centriolar Satellites and Causes Defective Sperm Flagellum Biogenesis and Male Fertility.
Li K, Zhou X, Liu W, Wang Y, Zhang Z, Zhang H, Jiang L
Cells 2025 Jul 23;14(15)
Cells 2025 Jul 23;14(15)
C20orf27 promotes hepatocellular carcinoma progression via NT5E.
He Y, Zhang W, Chang M, Chen Y, Lin R, Ye X, Mao W, Lu Y, Lu Y, Chen E
Discover oncology 2025 Jul 21;16(1):1379
Discover oncology 2025 Jul 21;16(1):1379
Deficiency of Rab26 causes behavioral defects in mice through impaired trafficking of serotonin (5-HT) transporter.
Ren Y, Wang Z, Wei Z, Zhuang R, Zhang Y, Liu X, Jiang C, Liu X, Yun Y, Li Y, Hong W, Wang T
iScience 2025 Jul 18;28(7):112931
iScience 2025 Jul 18;28(7):112931
PKA-mediated BMAL1 phosphorylation promotes β(1)-adrenoceptor autoantibody-induced cardiomyocyte death.
Yuan Y, Feng J, Xue L, Lu J, Ma M, Long Y, Li Y, Wang X, Wang L
iScience 2025 Jul 18;28(7):112786
iScience 2025 Jul 18;28(7):112786
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization.
Balch S, Sekne Z, Franco-Echevarría E, Ludzia P, Kretsch RC, Sun W, Yu H, Ghanim GE, Thorkelsson S, Ding Y, Das R, Nguyen THD
Science (New York, N.Y.) 2025 Jul 10;389(6756):eadr5817
Science (New York, N.Y.) 2025 Jul 10;389(6756):eadr5817
Valosin-containing protein mediates DNA-dependent protein kinase activation in response to DNA topoisomerase II-associated DNA double-strand breaks.
Sakasai R, Sunatani Y, Matsui T, Iwabuchi K
Journal of biochemistry 2025 Jul 1;178(1):51-60
Journal of biochemistry 2025 Jul 1;178(1):51-60
Positional BMP signaling orchestrates villus length in the small intestine.
Wang X, Li S, Liu Y, Kuang X, Chen J, Yu P, Zhao L, Zhang Z, Huang M, Liu L, Zhang M, Wang Y, Ji W, Li J, Zhang L, Chen YG
Nature communications 2025 Jul 1;16(1):5461
Nature communications 2025 Jul 1;16(1):5461
AK4 promotes nasopharyngeal carcinoma metastasis and chemoresistance by activating NLRP3 inflammatory complex.
Liu SL, Yuan L, Sun XS, Xiao BB, Lan KQ, Lu ZJ, Lin DF, Li XY, Yan JJ, Yan SM, Chen QY, Tang LQ, Mai HQ
Cell death & disease 2025 Jul 1;16(1):480
Cell death & disease 2025 Jul 1;16(1):480
Discovery of structurally diverse diazatricyclododecenes as lysosomotropic autophagy inhibitors.
Miura K, Umedera K, Doi T, Nakamura H
Bioorganic & medicinal chemistry 2025 Jul 1;124:118200
Bioorganic & medicinal chemistry 2025 Jul 1;124:118200
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture.
Pourmal S, Truong ME, Johnson MC, Yang Y, Zhou L, Alegre K, Stowe IB, Gupta S, Chen PA, Zhang Y, Rohou A, Newton K, Kayagaki N, Dixit VM, Deshpande I
Nature 2025 Jan;637(8045):446-452
Nature 2025 Jan;637(8045):446-452
Interaction Between Aging-Related Elastin-Derived Peptide (VGVAPG) and Sirtuin 2 and its Impact on Functions of Human Neuron Cells in an In Vitro Model.
Skóra B, Piechowiak T, Szychowski KA
Molecular neurobiology 2025 Jan;62(1):819-831
Molecular neurobiology 2025 Jan;62(1):819-831
A novel regulatory axis of MSI2-AGO2/miR-30a-3p-CGRRF1 drives cancer chemoresistance by upregulating the KRAS/ERK pathway.
Lu R, Zhang Y, Chen R, Li L, Huang C, Zhou Z, Cao Y, Li H, Li J, Zhang Y, Wang Y, Huang J, Zhao X, Feng J, Yu J, Du C
Neoplasia (New York, N.Y.) 2025 Jan;59:101082
Neoplasia (New York, N.Y.) 2025 Jan;59:101082
Correspondence to editorial on "UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL".
Zhang R, Wei D, Chen Z, Bian H
Clinical and molecular hepatology 2025 Jan;31(1):e58-e60
Clinical and molecular hepatology 2025 Jan;31(1):e58-e60
LAPTM5 Confers the Resistance to Venetoclax via Promoting the Autophagosome-Lysosome Fusion in Multiple Myeloma.
Li Y, Bai J, Liu D, Hao J, Yan R, Guo H, Huang Y, Yu H, Leng H, Zhou K, Liu M
Journal of cellular and molecular medicine 2025 Jan;29(1):e70331
Journal of cellular and molecular medicine 2025 Jan;29(1):e70331
β-fructofuranosidase regulation in silkworm silk gland development: Implications for silk gland morphogenesis and silk production.
Sun B, Zhang H, Chen C, Yan J, Hong J, Xu J, Chen K, Sun L
International journal of biological macromolecules 2025 Jan;285:138309
International journal of biological macromolecules 2025 Jan;285:138309
Ketogenic β-hydroxybutyrate regulates β-hydroxybutyrylation of TCA cycle-associated enzymes and attenuates disease-associated pathologies in Alzheimer's mice.
Han W, Zhang B, Zhao W, Zhao W, He J, Qiu X, Zhang L, Wang X, Wang Y, Lu H, Zhang Y, Xie Y, Geng Y, Zhao W, Huang Q, Zhang YW, Wang Z
Aging cell 2025 Jan;24(1):e14368
Aging cell 2025 Jan;24(1):e14368
HO-1-mediated ferroptosis regulates retinal neovascularization via the COX2/VEGFA axis.
Zhou H, Li B, Wang Z, Cai Y, Yoshida S, Zhou Y, Li Y
Free radical biology & medicine 2025 Jan;226:84-95
Free radical biology & medicine 2025 Jan;226:84-95
LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.
Fan L, Guo D, Zhu C, Gao C, Wang Y, Yin F, Liu M, Zhou Y, Wei T, Xiong X, Yu K, Le A
Free radical biology & medicine 2025 Jan;226:29-42
Free radical biology & medicine 2025 Jan;226:29-42
GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes.
Xing Y, Huang L, Jian Y, Zhang Z, Zhao X, Zhang X, Fu T, Zhang Y, Wang Y, Zhang X
Autophagy 2025 Jan;21(1):37-53
Autophagy 2025 Jan;21(1):37-53
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
Sun J, Ding J, Yue H, Xu B, Sodhi A, Xue K, Ren H, Qian J
Autophagy 2025 Jan;21(1):191-209
Autophagy 2025 Jan;21(1):191-209
HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1.
Lv P, Xu W, Xin S, Deng Y, Yang B, Xu D, Bai J, Ma D, Wang T, Liu J, Liu X
Reproductive biology and endocrinology : RB&E 2025 Jan 8;23(1):3
Reproductive biology and endocrinology : RB&E 2025 Jan 8;23(1):3
Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity.
Ru S, Tang S, Xu H, Yin J, Guo Y, Song L, Jin Z, Lee D, Chan YH, Chen X, Buerer L, Fairbrother W, Jia W, Casanova JL, Zhang SY, Gao D
The Journal of experimental medicine 2025 Jan 6;222(1)
The Journal of experimental medicine 2025 Jan 6;222(1)
D-ribose-5-phosphate inactivates YAP and functions as a metabolic checkpoint.
Tu CE, Liu YF, Liu HW, Jiao CM, Liu Q, Hung MC, Li P, Wan XB, Fan XJ, Wang YL
Journal of hematology & oncology 2025 Jan 4;18(1):2
Journal of hematology & oncology 2025 Jan 4;18(1):2
Rostellularia procumbens (L) Nees. extract attenuates adriamycin-induced nephropathy by maintaining mitochondrial dynamics balance via SIRT1/PGC-1α signaling pathway activation.
Ai Z, Yuan D, Dong R, Zhou S, Cao J
Journal of ethnopharmacology 2025 Jan 31;340:119297
Journal of ethnopharmacology 2025 Jan 31;340:119297
Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma.
Cheng Y, Chen X, Feng L, Yang Z, Xiao L, Xiang B, Wang X, Liu D, Lin P, Shi J, Song G, Qian W, Zhang B, Xu Y, Gao Z, Chen L, Wu Y, Ma J, Lin Y, Zhao H, Peng L, Mao X, Liu Y, Hou H, Yang M, Ji Y, Wang X, Zhou J, Xu X, Liu X, Wei W, Zhang X, Gao Q, Zhou H, Sun Y, Wu K, Fan J
Cell discovery 2025 Jan 28;11(1):1
Cell discovery 2025 Jan 28;11(1):1
Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.
Cai Z, Liang C, Huang K, Luo J, Lu R, Lai Y, Zheng D, Lin Z, Zhong J, Dai J, Huang J, Zhang H, Chen J
International immunopharmacology 2025 Jan 27;146:113928
International immunopharmacology 2025 Jan 27;146:113928
Extracellular vesicles from adipose-derived stem cell alleviate diabetic cardiomyopathy by regulating Chit1/NLRP3/Caspase-1-Mediated pyroptosis.
Zhang Y, Zhang L, Li P, Qiu L, Qu Y, Wu Y, Song H
International immunopharmacology 2025 Jan 27;146:113860
International immunopharmacology 2025 Jan 27;146:113860
A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer.
Meng X, Wu Q, Cao C, Yang W, Chu S, Guo H, Qi S, Bai J
Journal of translational medicine 2025 Jan 23;23(1):108
Journal of translational medicine 2025 Jan 23;23(1):108
Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation.
Ruan J, Wei X, Li S, Ye Z, Hu L, Zhuang R, Cao Y, Wang S, Wu S, Peng D, Chen S, Yuan S, Xu A
Cell discovery 2025 Jan 21;11(1):4
Cell discovery 2025 Jan 21;11(1):4
SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma.
Daley BR, Sealover NE, Finniff BA, Hughes JM, Sheffels E, Gerlach D, Hofmann MH, Kostyrko K, LaMorte JP, Linke AJ, Beckley Z, Frank AM, Lewis RE, Wilkerson MD, Dalgard CL, Kortum RL
Cancer research 2025 Jan 2;85(1):118-133
Cancer research 2025 Jan 2;85(1):118-133
The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis.
She P, Gao B, Li D, Wu C, Zhu X, He Y, Mo F, Qi Y, Jin D, Chen Y, Zhao X, Lin J, Hu H, Li J, Zhang B, Xie P, Lin C, Christoffels VM, Wu Y, Zhu P, Zhong TP
Nature communications 2025 Jan 2;16(1):232
Nature communications 2025 Jan 2;16(1):232
Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R-Ca(2+)-PIK3CA pathway.
Song L, Wu H, Sun X, Liu X, Ling X, Ni W, Li L, Liu B, Wei J, Li X, Li J, Wang Y, Mao F
iScience 2025 Jan 17;28(1):111640
iScience 2025 Jan 17;28(1):111640
Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer.
Liu L, Huang H, Cheng B, Xie H, Peng W, Cui H, Liang J, Cao M, Yang Y, Chen W, Wang R, Zhao Y
iScience 2025 Jan 17;28(1):111612
iScience 2025 Jan 17;28(1):111612
Abnormal methylation of Mill1 gene regulates osteogenic differentiation involved in various phenotypes of skeletal fluorosis in rats and methionine intervention.
Chen N, Zhang J, Yin C, Liao Y, Song L, Hu T, Pan X
Ecotoxicology and environmental safety 2025 Jan 15;290:117519
Ecotoxicology and environmental safety 2025 Jan 15;290:117519
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3.
Rao Y, Qin C, Savas AC, Liu Q, Feng S, Hou G, Xie T, Feng P
Immunity 2025 Jan 14;58(1):74-89.e6
Immunity 2025 Jan 14;58(1):74-89.e6
Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor.
Wang J, Chen M, Jiang J, Wan Y, Li X, Zhang M, Xiao F, Zhong L, Zhong H, Qin Z, Hou J
Journal of translational medicine 2025 Jan 13;23(1):62
Journal of translational medicine 2025 Jan 13;23(1):62
Application of genome tagging technology in elucidating the function of sperm-specific protein 411 (Ssp411).
Zhou XH, Hua MM, Tang JN, Wu BG, Wang XM, Shi CG, Yang Y, Wu J, Wu B, Zhang BL, Sun YS, Zhang TC, Shi HJ
Asian journal of andrology 2025 Jan 1;27(1):120-128
Asian journal of andrology 2025 Jan 1;27(1):120-128
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance.
Borankova K, Solny M, Krchniakova M, Skoda J
Life science alliance 2025 Feb;8(2)
Life science alliance 2025 Feb;8(2)
Novel variants in DNAH9 are present in two infertile patients with severe asthenospermia.
Yan F, Zhi W, Wei Y, Dai L, Xu W, Zheng R
Journal of human genetics 2025 Feb;70(2):105-111
Journal of human genetics 2025 Feb;70(2):105-111
Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice.
Huang LY, Liu YN, Chen J, Zhu HX, Li LL, Liang ZY, Song JX, Li YJ, Hu ZL, Demon D, Wullaert A, Wang W, Qi SH
Molecular neurobiology 2025 Feb;62(2):1705-1719
Molecular neurobiology 2025 Feb;62(2):1705-1719
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Gan X, Luo X, Chen J, Fang W, Nie M, Lu H, Liu Y, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Nicotinamide n-methyltransferase inhibitor synergizes with sodium-glucose cotransporter 2 inhibitor to protect renal tubular epithelium in experimental models of type 2 diabetes mellitus.
Yang Y, Li F, Li Y, Li X, Zhao Z, Zhang N, Li H
Journal of diabetes and its complications 2025 Feb;39(2):108952
Journal of diabetes and its complications 2025 Feb;39(2):108952
Acute heat stress upregulates Akr1b3 through Nrf-2 to increase endogenous fructose leading to kidney injury.
Wang S, Pang X, Cai Y, Tian X, Bai J, Xi M, Cao J, Jin L, Wang X, Wang T, Li D, Li M, Fan X
The Journal of biological chemistry 2025 Feb;301(2):108121
The Journal of biological chemistry 2025 Feb;301(2):108121
Artificial targeting of autophagy components to mitochondria reveals both conventional and unconventional mitophagy pathways.
Lorentzen KC, Prescott AR, Ganley IG
Autophagy 2025 Feb;21(2):315-337
Autophagy 2025 Feb;21(2):315-337
The Stimulator of Interferon Genes Deficiency Attenuates Diabetic Myopathy Through Inhibiting NLRP3-Mediated Pyroptosis.
Yang J, Wang M, Shi L, Fang X, Gao C, Ma L, Wang Y, Ying S, Yang Y
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13649
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13649
Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer.
Deng M, Zhou Z, Chen J, Li X, Liu Z, Ye J, Wei W, Wang N, Peng Y, Luo X, Jiang L, Zhou F, Zheng X, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2408599
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2408599
Deciphering TCOF1 mutations in Chinese Treacher Collins syndrome patients: insights into pathogenesis and transcriptional disruption.
Jiang Z, Mao K, Wang B, Zhu H, Liu J, Lang R, Xiao B, Shan H, Chen Q, Li Y, Zhao S, Zhang Q, Liu H, Zhang YB
Orphanet journal of rare diseases 2025 Feb 7;20(1):57
Orphanet journal of rare diseases 2025 Feb 7;20(1):57
A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice.
Han G, Li D, Zhang H, Li C, Yang L, Ma T, Wang X, Ma B, Wu X, Tao Y, Wang Z, Wang A, Chao HW, Jin Y, Chen H
Scientific data 2025 Feb 3;12(1):199
Scientific data 2025 Feb 3;12(1):199
ApoE2 affects insulin signaling in the hippocampus and spatial cognition of aged mice in a sex-dependent manner.
Wang Y, Liu H, Ye Y, Fang W, Lin A, Dai X, Ye Q, Chen X, Zhang J
Cell communication and signaling : CCS 2025 Feb 26;23(1):112
Cell communication and signaling : CCS 2025 Feb 26;23(1):112
Membrane-tethered SCOTIN condensates elicit an endoplasmic reticulum stress response by sequestering luminal BiP.
Jo A, Jung M, Mun JY, Kim YJ, Yoo JY
Cell reports 2025 Feb 25;44(2):115297
Cell reports 2025 Feb 25;44(2):115297
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3.
Ye L, Shen S, Mao Q, Lu H, Liu H, Zhang P, Jiang Z, Ma W, Sun Y, Chu Y, Zhou Z, Liu R, Li J, Li ST, Gao P, Zhang H
Cell reports 2025 Feb 25;44(2):115250
Cell reports 2025 Feb 25;44(2):115250
One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study.
Iversen JN, Tai YK, Yap JLY, Abdul Razar RBB, Sukumar VK, Wu KY, Ooi MG, Kukumberg M, Adam S, Rufaihah AJ, Franco-Obregón A
Cells 2025 Feb 23;14(5)
Cells 2025 Feb 23;14(5)
UFMylation maintains YAP stability to promote vascular endothelial cell senescence.
Liu Y, Zuo M, Wu A, Wang Z, Wang S, Bai Y, Zhou J, Wang H
iScience 2025 Feb 21;28(2):111854
iScience 2025 Feb 21;28(2):111854
Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis.
Chen L, Luo S, Liu T, Shuai Z, Song Y, Yang Q, Wang Y, Huang H, Luo Y
Journal of neuroinflammation 2025 Feb 21;22(1):44
Journal of neuroinflammation 2025 Feb 21;22(1):44
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.
Dan X, Croteau DL, Liu W, Chu X, Robbins PD, Bohr VA
bioRxiv : the preprint server for biology 2025 Feb 20;
bioRxiv : the preprint server for biology 2025 Feb 20;
Differential Mechanisms of Soybean-Derived ACE2-Activating Peptides IVPQ and IAVPT in ACE2-Mediated Endothelial Protection.
Zhou M, Song T, Huang M, Zheng L, Zhao M
Journal of agricultural and food chemistry 2025 Feb 19;73(7):4065-4077
Journal of agricultural and food chemistry 2025 Feb 19;73(7):4065-4077
Sephin1 suppresses ER stress-induced cell death by inhibiting the formation of PP2A holoenzyme.
Gojo S, Kami D, Sano A, Teruyama F, Ogata T, Matoba S
Cell death & disease 2025 Feb 19;16(1):117
Cell death & disease 2025 Feb 19;16(1):117
Impact of physiological ionic strength and crowding on kinesin-1 motility.
Sagawa M, Oiwa K, Kojima H, Furuta K, Shibata K
Cell structure and function 2025 Feb 18;50(1):41-51
Cell structure and function 2025 Feb 18;50(1):41-51
Tumour-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via the PI3K/Akt/mTOR pathway.
He L, Chen Q, Wu X
Journal of ovarian research 2025 Feb 15;18(1):28
Journal of ovarian research 2025 Feb 15;18(1):28
LRRC56 deletion causes primary ciliary dyskinesia in mice characterized by dynein arms defects.
Wu R, Li H, Wu P, Yang Q, Wan X, Wu Y
Biology open 2025 Feb 15;14(2)
Biology open 2025 Feb 15;14(2)
Non-catalytic mechanisms of KMT5C regulating hepatic gluconeogenesis.
Zhao Q, Cui X, Zhu Q, Li F, Bao R, Shi T, Liu H, Lv W, Xu Y, Gao Y, Tang QQ, Zhang M, Pan D
Nature communications 2025 Feb 10;16(1):1483
Nature communications 2025 Feb 10;16(1):1483
Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression.
Li X, Fu Y, Luo Y, Wang S, Zhao M, Chen Y
Redox biology 2025 Dec;88:103917
Redox biology 2025 Dec;88:103917
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Jia G, Li J, Jiang M, Liu N, Ding N, Jiang X, Zhang G, Tan X, Kang Y, Zhang L, Wang F, Zhang Y
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Pre-chelated gallium-loaded polydopamine nanoparticles as a multifunctional regulator of osteoblast/osteoclastogenesis for the synergistic therapy of periodontitis.
Jiang C, Chen X, Qin W, Gan N, Jiao T
Materials today. Bio 2025 Dec;35:102638
Materials today. Bio 2025 Dec;35:102638
Tumor PLA2G10 restrains CD4(+) T cell activation in lung adenocarcinoma via enhancing arachidonic acid secretion.
Tian Y, Ma QZ, Wang H, Shi MY, Zhao Y, Chen XH, Ma YX, Liu HG, Chen ZN, Chen R, Wang K
International journal of biological macromolecules 2025 Dec;334(Pt 2):149147
International journal of biological macromolecules 2025 Dec;334(Pt 2):149147
Bovine tubulin cofactor D (TBCD) disrupts tubulin dimers and inhibits tumor growth via the TNF-α signaling pathways-mediated ROS production.
Wang H, Guo J, Yang J, Wu X, Wu F, Wu H, Zhan Y, Zhang H
International journal of biological macromolecules 2025 Dec;334(Pt 1):148987
International journal of biological macromolecules 2025 Dec;334(Pt 1):148987
Elongator subunit Elp3 regulates reproduction in Tribolium castaneum by interacting with FOXO.
Ge H, Wei J, Guan D, Wang Z, Li H, Zhang H, Qian K, Wang J
Insect science 2025 Dec;32(6):2042-2052
Insect science 2025 Dec;32(6):2042-2052
A novel dual CDC25-HDAC inhibitor suppresses glioblastoma progression via chromosomal passenger complex disruption.
Upadhyay R, Sethy B, Yang WB, Wu MH, Liou KC, Wu AC, Narwanti I, Nepali K, Liou JP, Chuang JY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Dec;193:118816
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Dec;193:118816
Bombyx mori nucleopolyhedrosis virus-derived circular RNAs with protein-coding potential facilitate viral replication.
Zhang X, Shen Z, Kang Y, Yu W, Du X, Teng Q, He Z, Gong C, Hu X
Insect biochemistry and molecular biology 2025 Dec;185:104420
Insect biochemistry and molecular biology 2025 Dec;185:104420
Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway.
Dong Y, Meng F, Wang J, Wei J, Zhang K, Qin S, Li M, Wang F, Wang B, Liu T, Zhong W, Cao H
Gut microbes 2025 Dec;17(1):2446376
Gut microbes 2025 Dec;17(1):2446376
Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1.
Xue M, Huang C, Jiang X, Zhou S, Yan Y, Dong C, Chen Z, Dai J
Virulence 2025 Dec;16(1):2570000
Virulence 2025 Dec;16(1):2570000
Oncofetal dual‑specificity phosphatase 9 drives stem-like properties through ERK1/2-PPARG-SCD axis-mediated lipid metabolism in hepatocellular carcinoma.
Peng W, Huang H, Zhao Y, Zhou Q, Cao M, Liu L, Liang J, Cui H, Chen S, Chen W, Xiong S, Cheng B, Bai S
Clinical and translational medicine 2025 Dec;15(12):e70550
Clinical and translational medicine 2025 Dec;15(12):e70550
Mass Spectrometry-Based Proteomic Analysis of Porcine Reproductive and Respiratory Syndrome Virus NSP9 Protein with Host Proteins.
Wen W, Liu Y, Wang W, Zhu Z, Li X
Animals : an open access journal from MDPI 2025 Dec 5;15(24)
Animals : an open access journal from MDPI 2025 Dec 5;15(24)
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence.
Zhang C, Du Y, Ji Y, Ye X, Lian J, Zhou H, Gao Z, Xu H, Tang Y, Fan Y, Zheng L
Journal of experimental & clinical cancer research : CR 2025 Dec 4;45(1):13
Journal of experimental & clinical cancer research : CR 2025 Dec 4;45(1):13
Multi-Omics Analysis Reveals Distinct Lipid Remodelling and Mitochondrial Stress in SH-SY5Y Cells Modelling Parkinson's Disease.
Wang S, Ni Z, Wang G, Zhang J, Tan Y, Hong E, Wang Y, Chen H, Hou H, Hu Q
Metabolites 2025 Dec 4;15(12)
Metabolites 2025 Dec 4;15(12)
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
Wu H, Zhu G, Zhu Q, Ma J, Mao S, Ding M, Zhu J, Tang X, Bian Z, Shan Y, Gu S, Sun F, Jiang C, Pan Q
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
PRAS40 promotes colorectal cancer stemness by enhancing glycolysis through triggering PGK1 acetylation.
Zhang C, Bo Y, Zhang T, Chen X, Zhang T, Teng H, Wang Y, Luo Y, Sun J, Wang L, Wang X, Huang L
Oncogenesis 2025 Dec 27;15(1):2
Oncogenesis 2025 Dec 27;15(1):2
SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3's activity and promotes lung tumorigenesis.
Meng X, Wang W, Sheshadri N, Zhang T, Han X, Sun Y, Xiao M, Feng Y, Gao S, Chen J, Xie S, Wang Y, Yang Y, Zhao Y, Yin Y, Zong WX, Gao S
Cell death & disease 2025 Dec 24;17(1):133
Cell death & disease 2025 Dec 24;17(1):133
TRIM29 inhibits PRRSV replication by targeting nsp11 for degradation.
Wen W, Xue Z, Lu Y, Liu Y, Wang W, Zhu Z, Li X
Journal of virology 2025 Dec 23;99(12):e0151225
Journal of virology 2025 Dec 23;99(12):e0151225
DHX36 plays an oncogenic role in breast cancer progression and invasiveness.
Wei C, Xu D, Cheng J, Zheng M, Li T, Yang J, He J, El-Far AH, Zhang L, Xiao X, He T, Fu J
Scientific reports 2025 Dec 2;16(1):1156
Scientific reports 2025 Dec 2;16(1):1156
Decreased scleral Wnt5a(hi) fibroblasts exacerbate myopia progression by disrupting extracellular matrix homeostasis in mice.
Zhu H, Chen W, Ling X, Jiao S, Yu L, Liu H, Ding M, Zhang F, Zhou Y, Pan Y, Zhou Z, Qu J, Zhao F, Zhao F, Zhou X
Nature communications 2025 Dec 16;17(1):554
Nature communications 2025 Dec 16;17(1):554
Pathogenic Mechanism of the KCNQ4 Gene Variant in Hearing Loss and Functional Validation in a Zebrafish Model.
Jia H, Liu X, Chen H, Wang Y, Guan MX, Guo Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71274
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71274
The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution.
Turnbull ML, Zakaria MK, Upfold NS, Bakshi S, Magill C, Das UR, Clarke AT, Mojsiejczuk L, Herder V, Dee K, Liu N, Folwarczna M, Ilia G, Furnon W, Schultz V, Chen H, Devlin R, McCowan J, Young AL, Po WW, Smollett K, Yaseen MA, Ross R, Bhide A, van Kekem B, Fouchier RAM, da Silva Filipe A, Iqbal M, Roberts E, Hughes J, Werling D, Murcia PR, Palmarini M
Nature communications 2025 Dec 15;16(1):11042
Nature communications 2025 Dec 15;16(1):11042
RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether.
Yang Z, Nakajima S, Chen H, Chakrabarty Y, Feng H, Chan DC
Nature communications 2025 Dec 14;16(1):11260
Nature communications 2025 Dec 14;16(1):11260
Sodium disrupts mitochondrial energy metabolism to execute NECSO.
Qiao Y, Wang J, Wang B, Zhou H, Ni Q, Fu W, Hu Z, Zhong Q
Nature communications 2025 Dec 13;17(1):493
Nature communications 2025 Dec 13;17(1):493
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia.
Chen Y, Zhou Y, Qi Y, Miao T, Shi J, Jin D, Zhong TP
Communications biology 2025 Dec 10;9(1):33
Communications biology 2025 Dec 10;9(1):33
Knockdown of MiD49 and MiD51 alleviates collagen-induced arthritis and suppresses mitophagy and fatty acid oxidation (FAO) in rheumatoid arthritis fibroblast-like synoviocytes.
Liu J, Zhang C, Ma R, Yin C, Ren J, Yang S, Zhao Y, Tang Y, Wei J, Li X
Free radical biology & medicine 2025 Dec 1;240:514-531
Free radical biology & medicine 2025 Dec 1;240:514-531
LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.
Li JY, Li YQ, Dai JH, Gong S, He QM, Bai JW, Huang SW, Lu YQ, Duan YF, Feng SY, Tan XR, Liang XY, Ma J, Guo R, Liu N
The Journal of clinical investigation 2025 Dec 1;135(23)
The Journal of clinical investigation 2025 Dec 1;135(23)
Shank3 Regulates L-Type Voltage-Gated Ca(2+) Channels in the Mouse Striatum and Hippocampus at the Early Developmental Stage.
Yang CX, Yang P, Wen C, Wong LE, Chang S
The European journal of neuroscience 2025 Aug;62(3):e70206
The European journal of neuroscience 2025 Aug;62(3):e70206
The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response.
Wang H, Suh F, Fischietti M, Wray B, Filip SK, Faull PA, Hu L, Huang W, Liu B, Platanias LC, Eklund EA
The Journal of biological chemistry 2025 Aug;301(8):110484
The Journal of biological chemistry 2025 Aug;301(8):110484
HDGF derived from Müller cells enhances the activation of microglia in diabetic retinopathy.
Qiu A, Yin W, Wang N, Wang X, Liu Q, Zhang W
Journal of biomedical research 2025 Aug 7;40(1):63-75
Journal of biomedical research 2025 Aug 7;40(1):63-75
PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules.
Huang C, Huang J, Lu R, Yu AJ, Yu AS, Cao Y, Li L, Li J, Li H, Zhou Z, Zhang Y, Xu A, Chen R, Wang Y, Zhao X, Huang J, Fu Y, Xu M, Zhang H, Yu J
Nature communications 2025 Aug 7;16(1):7308
Nature communications 2025 Aug 7;16(1):7308
OFD1 inhibition induces BRCAness to create a therapeutic vulnerability to PARP inhibition in pancreatic cancer.
Li P, Ye J, Yang Q, Wang N, Li C, Zou X, Luo H, Pan Y, Jiang L, Shen B, Tang Z, Zhong Q
Nature communications 2025 Aug 5;16(1):7209
Nature communications 2025 Aug 5;16(1):7209
Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth.
Zhao G, Luo S, Zhao H, Ma Q, Jiang H, Wang L, Liu J, Guo D, Wang R, Xu Q, Lun J, Xie R, Duan Y, Ma L, Qiu W, Fang J, Lu Z
Nature communications 2025 Aug 4;16(1):7156
Nature communications 2025 Aug 4;16(1):7156
The Synergistic Role of P2rx7 and Panx1 in Regulating Alveolar Macrophage Pyroptosis and Exosome-Mediated Ferroptosis of Alveolar Epithelial Cells in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
Rao H, Ding Q, Liu A, Qiu H, Luo J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70904
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70904
Evidence that mitochondria in macrophages are destroyed by microautophagy.
Lu SL, Chen S, Noda K, Li Y, Tsai CY, Omori H, Kato Y, Zhang Z, Chen B, Tokuda K, Zheng T, Wakita M, Hara E, Fukuda M, Wada Y, Morita E, Uzawa N, Murakami S, Noda T
Nature communications 2025 Aug 30;16(1):8123
Nature communications 2025 Aug 30;16(1):8123
Sex-Specific Differences in the Revascularization of Grafted Pancreatic Islets.
Wrublewsky S, Widmann AV, Bickelmann C, Rafacho A, Roma LP, Laschke MW, Ampofo E
Cells 2025 Aug 29;14(17)
Cells 2025 Aug 29;14(17)
STAT3 haploinsufficiency is associated with autosomal dominant hyper-IgE syndrome.
Andreani V, Forde AJ, Fliegauf M, Bressan G, Noé V, Ott N, Saghafi S, Vornholz L, Isay SE, Ruland J, Henneke P, Grimbacher B
Science advances 2025 Aug 29;11(35):eadw2464
Science advances 2025 Aug 29;11(35):eadw2464
Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH.
Jayaram DT, Sivaram P, Biswas P, Dai Y, Sweeny EA, Stuehr DJ
Nature communications 2025 Aug 26;16(1):7972
Nature communications 2025 Aug 26;16(1):7972
Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma.
Huang H, Peng W, Zhou Q, Zhao Y, Liu L, Cui H, Liang J, Cao M, Chen W, Wang R, Chen S, Xiong S, Cheng B, Bai S
Cell communication and signaling : CCS 2025 Aug 25;23(1):379
Cell communication and signaling : CCS 2025 Aug 25;23(1):379
HMGB1/RAGE signaling mediates the activation of microglia and participates in depressive-like behaviors and cognitive deficits in rats after ischemia-reperfusion.
Fan L, Zhang X, Song X, Yang L, Liu H, Zhang Y, Li K, Jin X, Lei H, Zhang Z, Zhang F, Song J
Behavioural brain research 2025 Aug 24;492:115662
Behavioural brain research 2025 Aug 24;492:115662
Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching.
Würtz M, Tonon G, Vermeulen BJA, Zezlina M, Gao Q, Neuner A, Seidl A, König M, Harkenthal M, Eustermann S, Erhardt S, Lolicato F, Schiebel E, Pfeffer S
Nature communications 2025 Aug 22;16(1):7845
Nature communications 2025 Aug 22;16(1):7845
Paclitaxel neurotoxicity is triggered by epidermal EG5-dependent microtubule fasciculation and X-ROS formation.
Hsieh CJ, Cirrincione AM, Vlach MR, Diaz AC, Schmidt NA, Li X, Gutierrez S, Ugo MJ, Amaya Sanchez MC, Reimonn CA, Wuchty S, Pellegrini AD, Rude LR, Pappalardo LG, Regan DP, Zhao B, Zhang F, Howell C, Hrstka S, Dasari S, Capobianco E, Lisse TS, Harrison BJ, Staff NP, Xu MX, Rieger S
Research square 2025 Aug 20;
Research square 2025 Aug 20;
Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications.
Lu WM, Yan J, Liu ZJ, Wu Y, Cui QR, Feng J, Chen Y, Zhu GZ, Peng T, Zhou J, Lu GD
Parasites & vectors 2025 Aug 19;18(1):353
Parasites & vectors 2025 Aug 19;18(1):353
PDE4D Regulates Mitochondrial Homeostasis and Adult Hippocampal Neurogenesis via the cAMP/CREB Signaling Pathway in Chronic Stress-Induced Depressive-Like Behavior.
Zhao W, Wang Z, Chen X, Zhao S, Zong F, Zhang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 15;39(15):e70882
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 15;39(15):e70882
Inhibiting ANP32E protects against acute kidney injury by regulating autophagy via the AMPK pathway.
Wang C, Bai F, Li L, Yu K, Yang X
iScience 2025 Aug 15;28(8):113014
iScience 2025 Aug 15;28(8):113014
Mitochondria protect against an intracellular pathogen by restricting access to folate.
Medeiros TC, Ovciarikova J, Li X, Krueger P, Bartsch T, Reato S, Crow JC, Tellez Sutterlin M, Martins Garcia B, Rais I, Allmeroth K, Hartman MD, Denzel MS, Purrio M, Mesaros A, Leung KY, Greene NDE, Sheiner L, Giavalisco P, Pernas L
Science (New York, N.Y.) 2025 Aug 14;389(6761):eadr6326
Science (New York, N.Y.) 2025 Aug 14;389(6761):eadr6326
M-Sec Overexpressed Stem Cells Growing Abundant Tunneling Nanotubes for Diverse Active Transferring.
Che J, Cheng Y, Wu X, Wu Z, Shang L, Zhao Y
ACS nano 2025 Aug 12;19(31):28644-28659
ACS nano 2025 Aug 12;19(31):28644-28659
A casein-derived peptide exerted immunomodulatory effects by targeting protein phosphatase 1-catalytic subunit alpha: a potential alternative to combat infections.
Cai J, Wang S, Wu L, Liu X, Cao Y
Food & function 2025 Aug 11;16(16):6422-6433
Food & function 2025 Aug 11;16(16):6422-6433
Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression.
Wang K, Li J, Zhang H, Ma H, Cui HY, Ju HQ, Zhang J, Ma QZ, Zhao M, Zeng QM, Zou J, Sun XX, Nan G, Qian M, Jing L, Li Y, Xiong CF, Yang QZ, Wang H, Jiang JL, Chen ZN, Chen L, Huang W
Cancer research 2025 Aug 1;85(15):2838-2857
Cancer research 2025 Aug 1;85(15):2838-2857
Codelivery of NGFR100W and VEGFA mRNA Enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy.
Wang W, Yu X, Yang Z, Zhang Y, Yang W, Xu Y, Xu W
Diabetes 2025 Aug 1;74(8):1427-1440
Diabetes 2025 Aug 1;74(8):1427-1440
FOXK1 promotes hormonally responsive breast carcinogenesis by suppressing apoptosis.
Zhao M, Ma T, Zhang Z, Wang Y, Wang X, Wang W, Chen X, Gao R, Shan L
Animal models and experimental medicine 2025 Apr;8(4):638-648
Animal models and experimental medicine 2025 Apr;8(4):638-648
NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling.
Ji M, Cui W, Feng Q, Qi J, Wang X, Zhu H, Zhang W, Fu W
Life science alliance 2025 Apr;8(4)
Life science alliance 2025 Apr;8(4)
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
Wang G, Dai S, Chen J, Zhang K, Huang C, Zhang J, Xie K, Lin F, Wang H, Gao Y, Yin L, Jiang K, Miao Y, Lu Z
Cell death and differentiation 2025 Apr;32(4):702-713
Cell death and differentiation 2025 Apr;32(4):702-713
Enzymatic degraded polysaccharides from Enteromorpha prolifera inhibit the growth of THP-1 cells and induce apoptosis via the mitochondrial pathway.
Jing D, Su Y, Xu Y, He Z, Hu J, Chen X, Zhou Z, Zhong M, Hu Z, Li J, Mao A
International journal of biological macromolecules 2025 Apr;303:140682
International journal of biological macromolecules 2025 Apr;303:140682
The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins.
Liu D, Huo XY, Zhang X, Zhang ZR
The Journal of biological chemistry 2025 Apr;301(4):108403
The Journal of biological chemistry 2025 Apr;301(4):108403
Targeting GPX4 alleviates ferroptosis and retards abdominal aortic aneurysm formation.
Shi Y, Zhao Y, Sun SJ, Lan XT, Wu WB, Zhang Z, Chen YX, Yan YY, Xu YP, Li DJ, Fu H, Shen FM
Biochemical pharmacology 2025 Apr;234:116800
Biochemical pharmacology 2025 Apr;234:116800
β-hydroxybutyrylation and O-GlcNAc modifications of STAT1 modulate antiviral defense in aging.
Zuo Y, Wang Q, Tian W, Zheng Z, He W, Zhang R, Zhao Q, Miao Y, Yuan Y, Wang J, Zheng H
Cellular & molecular immunology 2025 Apr;22(4):403-417
Cellular & molecular immunology 2025 Apr;22(4):403-417
EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA.
Tan R, Zhang Y, Huang M, Chen H, Liu Z, Wang Z, Li X, Wang T, Wang Z
PLoS pathogens 2025 Apr;21(4):e1013098
PLoS pathogens 2025 Apr;21(4):e1013098
ATP depletion in anthrax edema toxin pathogenesis.
Liu J, Cao Q, Ewing M, Zuo Z, Kennerdell JR, Finkel T, Leppla SH, Liu S
PLoS pathogens 2025 Apr;21(4):e1013017
PLoS pathogens 2025 Apr;21(4):e1013017
circEgg inhibits BmCPV infection by regulating the transition between H3K9me3 and H3K9ac.
Qiu Q, Tong X, Zhu M, Liu Z, Yin M, Jiang S, Li L, Huang Y, Feng Y, Hu X, Gong C
Pesticide biochemistry and physiology 2025 Apr;209:106334
Pesticide biochemistry and physiology 2025 Apr;209:106334
Zika and dengue viruses differentially modulate host mRNA processing factors defining its virulence.
Scholl A, Gong B, Li B, Fatima T, Tirrell N, Karaiskos S, Rios M, Xu J, De S
NAR molecular medicine 2025 Apr;2(2)
NAR molecular medicine 2025 Apr;2(2)
Isovaleroylbinankadsurin A ameliorates atherosclerosis and restenosis by promoting LXRα signaling pathway and inhibiting TGF-β1 and FHL1 signaling pathways.
Shi Y, Liu L, Gong Y, Zhang C, Yang Y, Wang W, Qin L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156451
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156451
Deciphering the role of ELAVL1: Insights from pan-cancer multiomics analyses with emphasis on nasopharyngeal carcinoma.
Xie J, Xie Y, Tan W, Ye Y, Ou X, Zou X, He Z, Wu J, Deng X, Tang H, He L, Li K, Luo P, Bai K, Huang G, Li J
Journal of translational internal medicine 2025 Apr;13(2):138-155
Journal of translational internal medicine 2025 Apr;13(2):138-155
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases.
Mu W, Xu G, Li L, Wen J, Xiu Y, Zhao J, Liu T, Wei Z, Luo W, Yang H, Wu Z, Zhan X, Xiao X, Bai Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2417686
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2417686
Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING-Mediated Glycolysis.
Huang H, Han Y, Zhang Y, Zeng J, He X, Cheng J, Wang S, Xiong Y, Yin H, Yuan Q, Huang L, Xie Y, Meng J, Tao L, Peng Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2408753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2408753
Effects of cellular membranes and the precore protein on hepatitis B virus core particle assembly and DNA replication.
Chuang Y-C, Ou J-hJ
mBio 2025 Apr 9;16(4):e0397224
mBio 2025 Apr 9;16(4):e0397224
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure.
Yuan Y, Qian L, Miao Y, Cui Q, Cao T, Yu Y, Zhang T, Zhao Q, Zhang R, Ren T, Zuo Y, Du Q, Qiao C, Wu Q, Zheng Z, Li M, Chinn YE, Xu W, Peng T, Chen R, Xiong S, Zheng H
Cell discovery 2025 Apr 8;11(1):34
Cell discovery 2025 Apr 8;11(1):34
Coevolving residues distant from the ligand binding site are involved in GAF domain function.
Ahmed WS, Geethakumari AM, Sultana A, Tiwari A, Altamash T, Arshad N, Visweswariah SS, Biswas KH
Communications chemistry 2025 Apr 7;8(1):107
Communications chemistry 2025 Apr 7;8(1):107
Deletion of HIF-2α in Dendritic Cells Attenuates Anti-Glomerular Basement Membrane Nephritis.
Miao J, Qu J, Li D, Zhang M
Biomedicines 2025 Apr 7;13(4)
Biomedicines 2025 Apr 7;13(4)
Targeting the liquid-liquid phase separation of nucleocapsid broadly inhibits the replication of SARS-CoV-2 strains.
Gu L, Wang ZJ, Zhang XR, Liu Y, Zhao M, Jiang SZ, Pan J, Yuan Y, Cai H, Zhou T, Li T, Li TT, Xue W
Biochemical and biophysical research communications 2025 Apr 5;756:151594
Biochemical and biophysical research communications 2025 Apr 5;756:151594
Trifluridine/tipiracil induces ferroptosis by targeting p53 via the p53-SLC7A11 axis in colorectal cancer 3D organoids.
Huang M, Wu Y, Wei X, Cheng L, Fu L, Yan H, Wei W, Li B, Ru H, Mo X, Tang W, Su Z, Yan L
Cell death & disease 2025 Apr 5;16(1):255
Cell death & disease 2025 Apr 5;16(1):255
Prognostic model of osteosarcoma based on telomere-related genes and analysis of immune characteristics.
Liu Z, Liu X
International immunopharmacology 2025 Apr 4;151:114198
International immunopharmacology 2025 Apr 4;151:114198
Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer.
Liang X, Tian R, Li T, Wang H, Qin Y, Qian M, Fan J, Wang D, Cui HY, Jiang J
Cell death discovery 2025 Apr 4;11(1):139
Cell death discovery 2025 Apr 4;11(1):139
Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by Sox9+ tumor cells interaction with Fpr1+ neutrophils.
Wang X, Cheng M, Chen S, Zhang C, Ling R, Qiu S, Chen K, Zhou B, Li Q, Lei W, Chen D
Nature communications 2025 Apr 28;16(1):3975
Nature communications 2025 Apr 28;16(1):3975
HDAC11 Inhibition as a Potential Therapeutic Strategy for AML: Target Identification, Lead Discovery, Antitumor Potency, and Mechanism Investigation.
Yang M, Zhao W, Zhang J, Liu L, Tian S, Miao Y, Jia Y, Wang L, Chai Q, Wang Q, Liu F, Zhang Y, You X
Journal of medicinal chemistry 2025 Apr 24;68(8):8124-8142
Journal of medicinal chemistry 2025 Apr 24;68(8):8124-8142
Keto Acids Attenuate Skeletal Muscle Atrophy in Chronic Kidney Disease via Inhibiting Pyroptosis and Upregulating Irisin Precursor FNDC5 Expression.
Wang P, Pang Q, Zhang A
Calcified tissue international 2025 Apr 24;116(1):63
Calcified tissue international 2025 Apr 24;116(1):63
Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body.
Du Q, He W, Chen X, Liu J, Guan M, Chen Y, Chen M, Yuan Y, Zuo Y, Miao Y, Wang Q, Zhou H, Liu Y, Jiang J, Zheng H
Cell reports 2025 Apr 22;44(4):115481
Cell reports 2025 Apr 22;44(4):115481
The structural protein VP3 of enterovirus D68 interacts with MAVS to inhibit the NF-κB signaling pathway.
Chen H, Huang M, Hou B, Liu Z, Tan R, Cui L, Wang T, Wang Z
Journal of virology 2025 Apr 15;99(4):e0016325
Journal of virology 2025 Apr 15;99(4):e0016325
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity.
Zhou X, Zhu D, Wu D, Li G, Liang H, Zhang W, Wu Y, Xu H, Zhang Z, Tong B, Song Y, Wang K, Feng X, Lei J, Wang H, Zhang X, Ma L, Chen Y, Wei J, Ou Z, Peng S, Wu X, Tan L, Wang B, Yang C
Cell reports. Medicine 2025 Apr 15;6(4):102079
Cell reports. Medicine 2025 Apr 15;6(4):102079
Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13.
Xia M, Li Z, Jiang H, Li Y, Hu L, He Y, Huang S, Tang L, Luo C, Gu S, Ding H, Wang M
European journal of medicinal chemistry 2025 Apr 15;288:117378
European journal of medicinal chemistry 2025 Apr 15;288:117378
The LysoPS/GPR174 axis drives metastatic progression in esophageal squamous cell carcinoma through cAMP-PKA-CREB signaling activation.
Xiao R, Xu P, Li X, Shen F, Tao S, Zhu X, Cai Y, Feng Z, Liu Z, Xiao H, Ding F, Zhu M
Journal of translational medicine 2025 Apr 14;23(1):438
Journal of translational medicine 2025 Apr 14;23(1):438
LRG1 promotes the apoptosis of pulmonary microvascular endothelial cells through KLK10 in chronic obstructive pulmonary disease.
Cheng W, Song Q, Zhou A, Lin L, Zhao Y, Duan J, Zhou Z, Peng Y, Liu C, Zeng Y, Chen P
Tobacco induced diseases 2024;22
Tobacco induced diseases 2024;22
Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.
Xiang L, Pan W, Chen H, Du W, Xie S, Liang X, Yang F, Niu R, Huang C, Luo M, Xu Y, Geng L, Gong S, Xu W, Zhao J
Mediators of inflammation 2024;2024:7524314
Mediators of inflammation 2024;2024:7524314
IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.
Liu K, Huang H, Xiong M, Wang Q, Chen X, Feng Y, Ma H, Chen W, Li X, Ye X
International journal of biological sciences 2024;20(6):2323-2338
International journal of biological sciences 2024;20(6):2323-2338
Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic Retinopathy.
Wu X, Qin B, Cheng R, Zhou R, Wang X, Zhang Z, Mao X, Xie Z, Chen M, Jiang L, Xie P, Ji J, Zhang W, Yuan S, Hu Z, Liu Q
International journal of biological sciences 2024;20(3):897-915
International journal of biological sciences 2024;20(3):897-915
ESM1 facilitates the EGFR/HER3-triggered epithelial-to-mesenchymal transition and progression of gastric cancer via modulating interplay between Akt and angiopoietin-2 signaling.
Yang YC, Ho KH, Pan KF, Hua KT, Tung MC, Ku CC, Chen JQ, Hsiao M, Chen CL, Lee WJ, Chien MH
International journal of biological sciences 2024;20(12):4819-4837
International journal of biological sciences 2024;20(12):4819-4837
Enhancing mitophagy by ligustilide through BNIP3-LC3 interaction attenuates oxidative stress-induced neuronal apoptosis in spinal cord injury.
Yao H, Cai C, Huang W, Zhong C, Zhao T, Di J, Tang J, Wu D, Pang M, He L, Rong L, Liu B
International journal of biological sciences 2024;20(11):4382-4406
International journal of biological sciences 2024;20(11):4382-4406
Medioresinol from Eucommiae cortex improves myocardial infarction-induced heart failure through activation of the PI3K/AKT/mTOR pathway: A network analysis and experimental study.
Qin X, Liu X, Guo C, Huang L, Xu Q
PloS one 2024;19(9):e0311143
PloS one 2024;19(9):e0311143
Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer.
Anchoori RK, Tseng SH, Tsai HL, Palande V, Rudek MA, Roden RBS
PloS one 2024;19(7):e0305710
PloS one 2024;19(7):e0305710
Ninjin'yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice.
Otsuka S, Matsuzaki R, Kakimoto S, Tachibe Y, Kawatani T, Takada S, Tani A, Nakanishi K, Matsuoka T, Kato Y, Inadome M, Nojima N, Sakakima H, Mizuno K, Matsubara Y, Maruyama I
PloS one 2024;19(5):e0303833
PloS one 2024;19(5):e0303833
Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo.
Vermehren-Schmaedick A, Peto M, Wagoner W, Chiotti KE, Ramsey E, Wang X, Rakshe S, Minnier J, Sears R, Spellman P, Luoh SW
PloS one 2024;19(5):e0302856
PloS one 2024;19(5):e0302856
Mitochondrial DNA drives neuroinflammation through the cGAS-IFN signaling pathway in the spinal cord of neuropathic pain mice.
Huang P, Li L, Chen Y, Li Y, Zhu D, Cui J
Open life sciences 2024;19(1):20220872
Open life sciences 2024;19(1):20220872
Surgery induces neurocognitive disorder via neuroinflammation and glymphatic dysfunction in middle-aged mice with brain lymphatic drainage impairment.
Zhu X, Lin J, Yang P, Wu S, Lin H, He W, Lin D, Cao M
Frontiers in neuroscience 2024;18:1426718
Frontiers in neuroscience 2024;18:1426718
Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer.
Qin S, Jin H, Li Y, Chen X, He J, Xiao J, Qin Y, Liu C, Mao Y, Zhao L
Journal of Cancer 2024;15(9):2845-2865
Journal of Cancer 2024;15(9):2845-2865
miR-141-3p promotes paclitaxel resistance by attenuating ferroptosis via the Keap1-Nrf2 signaling pathway in breast cancer.
Duan WL, Wang XJ, Guo A, Gu LH, Sheng ZM, Luo H, Yang LX, Wang WH, Zhang BG
Journal of Cancer 2024;15(17):5622-5635
Journal of Cancer 2024;15(17):5622-5635
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Wang M, Zhang H, Lu Z, Su W, Tan Y, Wang J, Jia X
Journal of Cancer 2024;15(10):3183-3198
Journal of Cancer 2024;15(10):3183-3198
Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.
Xu AL, Shen Z, Wang SH, Luan HY, Xu Y, Kang ZC, Liao ZQ, Liu J, Duan XL, Bian WH, Sun H, Xie X
Frontiers in pharmacology 2024;15:1496380
Frontiers in pharmacology 2024;15:1496380
Pan-cancer analysis and experimental validation of FPR3 as a prognostic and immune infiltration-related biomarker for glioma.
Ye C, Li P, Chen B, Mo Y, Huang Q, Li Q, Hou Q, Mo L, Yan J
Frontiers in genetics 2024;15:1466617
Frontiers in genetics 2024;15:1466617
Neuron stress-related genes serve as new biomarkers in hypothalamic tissue following high fat diet.
Liang C, Lu H, Wang X, Su J, Qi F, Shang Y, Li Y, Zhang D, Duan C
Frontiers in endocrinology 2024;15:1443880
Frontiers in endocrinology 2024;15:1443880
Liquiritin ameliorates painful diabetic neuropathy in SD rats by inhibiting NLRP3-MMP-9-mediated reversal of aquaporin-4 polarity in the glymphatic system.
Jia SY, Yin WQ, Xu WM, Li J, Yan W, Lin JY
Frontiers in pharmacology 2024;15:1436146
Frontiers in pharmacology 2024;15:1436146
Phosphoenolpyruvate carboxykinase 2-mediated metabolism promotes lung tumorigenesis by inhibiting mitochondrial-associated apoptotic cell death.
Zhang J, He W, Liu D, Zhang W, Qin H, Zhang S, Cheng A, Li Q, Wang F
Frontiers in pharmacology 2024;15:1434988
Frontiers in pharmacology 2024;15:1434988
Critical role of G3BP1 in bovine parainfluenza virus type 3 (BPIV3)-inhibition of stress granules formation and viral replication.
Liu N, Yang W, Luo L, Ma M, Cui J, Dong X, Li Y
Frontiers in immunology 2024;15:1358036
Frontiers in immunology 2024;15:1358036
Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway.
Gao F, Zhu F, Shuai B, Wu M, Wei C, Yuan Y, Gui Y, Tian Y, Fan H, Wu H
Frontiers in pharmacology 2024;15:1351538
Frontiers in pharmacology 2024;15:1351538
Caspase-mediated AURKA cleavage at Asp(132) is essential for paclitaxel to elicit cell apoptosis.
Chen X, Du S, Zhang Y, Peng K, Liu L, Wang T, Zhang H, Cai S, Zhu C, Li Y, Tuo W, Wang Y, Wei F, Cai Q
Theranostics 2024;14(10):3909-3926
Theranostics 2024;14(10):3909-3926
Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells.
Haight JA, Koppenhafer SL, Geary EL, Gordon DJ
Frontiers in oncology 2024;14:1394653
Frontiers in oncology 2024;14:1394653
Decreased expression of LncRNA CRYM-AS1 promotes apoptosis through the Hippo-YAP1 signaling pathway leading to diabetic erectile dysfunction.
Zhang ZB, Chen Y, Huang ZS, Du ZJ, Wang W, Tang BW, Yuan SS, Chen DL, Zhu SG, Chen J
American journal of clinical and experimental urology 2024;12(5):226-239
American journal of clinical and experimental urology 2024;12(5):226-239
Bone marrow stromal and anterior cruciate ligament remnant cell co-culture-derived extracellular vesicles promote cell activity in both cell types.
Lin SY, Wu SC, Liu ZM, Chou PP, Zhao C, Ho ML, Lu CC
Journal of cellular and molecular medicine 2024 Sep;28(17):e70049
Journal of cellular and molecular medicine 2024 Sep;28(17):e70049
DCAF7 Acts as A Scaffold to Recruit USP10 for G3BP1 Deubiquitylation and Facilitates Chemoresistance and Metastasis in Nasopharyngeal Carcinoma.
Li QJ, Fang XL, Li YQ, Lin JY, Huang CL, He SW, Huang SY, Li JY, Gong S, Liu N, Ma J, Zhao Y, Tang LL
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2403262
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2403262
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Xie H, Yang N, Lu L, Sun X, Li J, Wang X, Guo H, Zhou L, Liu J, Wu H, Yu C, Zhang W, Lu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Effect of lyophilized exosomes derived from umbilical cord stem cells on chronic anterior cruciate ligament cell injury.
Lo HL, Lin SY, Ho CJ, Ming-Kung Y, Lu CC
Journal of orthopaedic surgery and research 2024 Sep 9;19(1):554
Journal of orthopaedic surgery and research 2024 Sep 9;19(1):554
Dihydromyricetin ameliorates diabetic renal fibrosis via regulating SphK1 to suppress the activation of NF-κB pathway.
Wen M, Sun X, Pan L, Jing S, Zhang X, Liang L, Xiao H, Liu P, Xu Z, Zhang Q, Huang H
European journal of pharmacology 2024 Sep 5;978:176799
European journal of pharmacology 2024 Sep 5;978:176799
12-HETE/GPR31 induces endothelial dysfunction in diabetic retinopathy.
Chen S, Qin X, Sun Y, Ma Z, Niu C, Xu Y, Lu L, Zou H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70064
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70064
SLC7A11-mediated cystine import protects against NDUFS7 deficiency-induced cell death in HEK293T cells.
Chen J, Gao L
Biochemical and biophysical research communications 2024 Sep 3;723:150178
Biochemical and biophysical research communications 2024 Sep 3;723:150178
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
The oncogenic ADAMTS1-VCAN-EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma.
Wen YC, Lin YW, Ho KH, Yang YC, Lai FR, Chu CY, Chen JQ, Lee WJ, Chien MH
Cellular & molecular biology letters 2024 Sep 27;29(1):126
Cellular & molecular biology letters 2024 Sep 27;29(1):126
AntigenBoost: enhanced mRNA-based antigen expression through rational amino acid substitution.
Gao Y, Zhu S, Li H, Hao X, Chen W, Pan D, Qian Z
Briefings in bioinformatics 2024 Sep 23;25(6)
Briefings in bioinformatics 2024 Sep 23;25(6)
Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production.
Yang E, Jing S, Wang F, Wang H, Fu S, Yang L, Tian J, Golijanin DJ, El-Deiry WS, Cheng L, Wang Z
Cell death & disease 2024 Sep 20;15(9):688
Cell death & disease 2024 Sep 20;15(9):688
Liquid-liquid phase separation is essential for reovirus viroplasm formation and immune evasion.
He L, Wang Q, Wang X, Zhou F, Yang C, Li Y, Liao L, Zhu Z, Ke F, Wang Y
Journal of virology 2024 Sep 17;98(9):e0102824
Journal of virology 2024 Sep 17;98(9):e0102824
Interleukin-1 increases SERPINE1 expression in human granulosa-lutein cell via P50/P52 signaling pathways.
Xiang Y, Liu S, Wan S, Chen Q, Song Y, Feng G, Zhang X, Bai L, Zhu Y
Molecular and cellular endocrinology 2024 Sep 15;591:112274
Molecular and cellular endocrinology 2024 Sep 15;591:112274
Nuclear translocation of nucleotide enzyme Phosphoglucomutase 2 governs DNA damage response and anti-tumor immunity.
Lyu Y, Liu C, Lin H, Song H, Zhuang Q, Hu A, Chen L, Yang H, Mao Y
Heliyon 2024 Sep 15;10(17):e36415
Heliyon 2024 Sep 15;10(17):e36415
Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer.
Wang C, Fang Y, Zhou Z, Liu Z, Feng F, Wan X, Li Y, Liu S, Ding J, Zhang ZM, Xie H, Lu X
Journal of medicinal chemistry 2024 Sep 12;67(17):15816-15836
Journal of medicinal chemistry 2024 Sep 12;67(17):15816-15836
Hypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue of male mice.
Jiang X, Liu K, Luo P, Li Z, Xiao F, Jiang H, Wu S, Tang M, Yuan F, Li X, Shu Y, Peng B, Chen S, Ni S, Guo F
Nature communications 2024 Sep 11;15(1):7948
Nature communications 2024 Sep 11;15(1):7948
Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke.
Gu Z, Li S, Liu J, Zhang X, Pang C, Ding L, Cao C
Biochemical and biophysical research communications 2024 Sep 10;724:150216
Biochemical and biophysical research communications 2024 Sep 10;724:150216
Trim31 deficiency exacerbates airway inflammation in asthma by enhancing the activation of the NLRP3 inflammasome.
Xue J, Jiang C, Chen X, Wang L
International immunopharmacology 2024 Sep 10;138:112591
International immunopharmacology 2024 Sep 10;138:112591
Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance.
Zhang Z, Zhao M, Wang Q, Wang X, Wang Y, Ge Y, Wu Z, Wang W, Shan L
Cancer letters 2024 Sep 1;599:217147
Cancer letters 2024 Sep 1;599:217147
Ceftazidime is a potential drug to inhibit cell proliferation by increasing cellular p27.
Zhang T, Qiao C, Yang Y, Yuan Y, Zhao Z, Miao Y, Zhao Q, Zhang R, Zheng H
The Journal of antibiotics 2024 Oct;77(10):697-705
The Journal of antibiotics 2024 Oct;77(10):697-705
Insulin-transferrin-selenium promote formation of tissue-engineered vascular grafts in early stage of culture.
Sun X, Wang N, Jiang H, Liu Q, Xiao C, Xu J, Wu Y, Mei J, Wu S, Lin Z
Preparative biochemistry & biotechnology 2024 Oct;54(9):1186-1195
Preparative biochemistry & biotechnology 2024 Oct;54(9):1186-1195
COLEC10 inhibits the stemness of hepatocellular carcinoma by suppressing the activity of β-catenin signaling.
Cai MN, Chen DM, Chen XR, Gu YR, Liao CH, Xiao LX, Wang JL, Lin BL, Huang YH, Lian YF
Cellular oncology (Dordrecht, Netherlands) 2024 Oct;47(5):1897-1910
Cellular oncology (Dordrecht, Netherlands) 2024 Oct;47(5):1897-1910
EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β.
Qian X, Cai J, Zhang Y, Shen S, Wang M, Liu S, Meng X, Zhang J, Ye Z, Qiu S, Zhong X, Gao P
The EMBO journal 2024 Oct;43(19):4248-4273
The EMBO journal 2024 Oct;43(19):4248-4273
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC
Cell research 2024 Oct;34(10):683-706
Cell research 2024 Oct;34(10):683-706
TRAF2 associates with cullin neddylation complex assembly.
Wang T, Zhang Q, Xu Y, Yan R, Pan Y, Xuan Y, Shen M, Chen X, Zhu H, Ke X, Qu Y, Zhang X
The FEBS journal 2024 Oct;291(20):4473-4488
The FEBS journal 2024 Oct;291(20):4473-4488
LncRNA MFRL regulates the phenotypic switch of vascular smooth muscle cells to attenuate arterial remodeling by encoding a novel micropeptide MFRLP.
Liu X, Chen S, Luo W, Yu C, Yan S, Lei L, Qiu S, Lin X, Feng T, Shi J, Zhang Q, Liang H, Liu X, Lee AP, Zheng L, Zhang X, Xiu J
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:54-67
Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:54-67
Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling.
Kalarikkal M, Saikia R, Oliveira L, Bhorkar Y, Lonare A, Varshney P, Dhamale P, Majumdar A, Joseph J
EMBO reports 2024 Oct;25(10):4226-4251
EMBO reports 2024 Oct;25(10):4226-4251
Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis.
Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA Jr, Davey RA
Antiviral research 2024 Oct;230:105976
Antiviral research 2024 Oct;230:105976
Cyclopeptide Inhibitors Target the N-Terminal Tail of STING and Alleviate Autoinflammation.
Wang X, Cao A, Zheng W, Quan J
Chemistry & biodiversity 2024 Oct;21(10):e202401253
Chemistry & biodiversity 2024 Oct;21(10):e202401253
BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer.
Liu N, Wang S, Li M, Zhao N, Wang D, Zhang R, Yu M, Zhao L, Zhang S, Han F, Zhao Y, Liu Q
Pharmacological research 2024 Oct;208:107377
Pharmacological research 2024 Oct;208:107377
Lysine lactylation-based insight to understanding the characterization of cervical cancer.
He C, Zhang J, Bai X, Lu C, Zhang K
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167356
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167356
Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy.
Ji Y, Li C, Wan S, Dong Z, Liu C, Guo L, Shi S, Ci M, Xu M, Li Q, Hu H, Cui H, Liu Y
Journal of pharmaceutical analysis 2024 Oct;14(10):101036
Journal of pharmaceutical analysis 2024 Oct;14(10):101036
Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model.
Zhao M, Cheng X, Chen L, Zeng YH, Lin KJ, Li YL, Zheng ZH, Huang XJ, Zuo DD, Guo XX, Guo J, He D, Liu Y, Lin Y, Wang C, Lv WQ, Su HZ, Yao XP, Ye ZL, Chen XH, Lu YQ, Huang CW, Yang G, Zhang YX, Lin MT, Wang N, Xiong ZQ, Chen WJ
Neuron 2024 Oct 9;112(19):3278-3294.e7
Neuron 2024 Oct 9;112(19):3278-3294.e7
NEK10 kinase ablation affects mitochondrial morphology, function and protein phosphorylation status.
de Oliveira AP, Navarro CDC, Dias PRF, Arguello T, Walker BR, Bacman SR, Sousa LM, Castilho RF, Consonni SR, Moraes CT, Kobarg J
Proteome science 2024 Oct 8;22(1):8
Proteome science 2024 Oct 8;22(1):8
Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation.
Zhou H, Patel V, Rice R, Lee R, Kim HW, Weintraub NL, Su H, Chen W
Cells 2024 Oct 5;13(19)
Cells 2024 Oct 5;13(19)
High androgen level during controlled ovarian stimulation cycle impairs endometrial receptivity in PCOS patients.
Wei SY, Zhang JL, Guan HQ, Cai JJ, Jiang XF, Wang H, Wu DD, Lin XH
Scientific reports 2024 Oct 4;14(1):23100
Scientific reports 2024 Oct 4;14(1):23100
A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.
Berquez M, Li AL, Luy MA, Venida AC, O'Loughlin T, Rademaker G, Barpanda A, Hu J, Yano J, Wiita A, Gilbert LA, Bruno PM, Perera RM
bioRxiv : the preprint server for biology 2024 Oct 29;
bioRxiv : the preprint server for biology 2024 Oct 29;
CHIP drives proteasomal degradation of NUR77 to alleviate oxidative stress and intrinsic apoptosis in cisplatin-induced nephropathy.
Zhang H, Deng Z, Wang Y, Zheng X, Zhou L, Yan S, Wang Y, Dai Y, Kanwar YS, Chen F, Deng F
Communications biology 2024 Oct 26;7(1):1403
Communications biology 2024 Oct 26;7(1):1403
Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response.
Han Y, Sheng W, Liu X, Liu H, Jia X, Li H, Wang C, Wang B, Hu T, Ma Y
Scientific reports 2024 Oct 23;14(1):24948
Scientific reports 2024 Oct 23;14(1):24948
C/EBPα-mediated ACSL4-dependent ferroptosis exacerbates tubular injury in diabetic kidney disease.
Xia Z, Wei Z, Li X, Liu Y, Gu X, Tong J, Huang S, Zhang X, Wang W
Cell death discovery 2024 Oct 23;10(1):448
Cell death discovery 2024 Oct 23;10(1):448
Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus.
Badu P, Baniulyte G, Sammons MA, Pager CT
Journal of virology 2024 Oct 22;98(10):e0105524
Journal of virology 2024 Oct 22;98(10):e0105524
Polystyrene microplastics trigger testosterone decline via GPX1.
Qu J, Wu L, Mou L, Liu C
The Science of the total environment 2024 Oct 15;947:174536
The Science of the total environment 2024 Oct 15;947:174536
An optofluidic system for the concentration gradient screening of oocyte protection drugs.
Yang D, Hu Q, Zhao S, Hu X, Gao X, Dai F, Zheng Y, Yang Y, Cheng Y
Talanta 2024 Oct 1;278:126472
Talanta 2024 Oct 1;278:126472
Dimethyl Sulfoxide Attenuates Ionizing Radiation-induced Centrosome Overduplication and Multipolar Cell Division in Human Induced Pluripotent Stem Cells.
Shimada M, Hirayama R, Matsumoto Y
Radiation research 2024 Oct 1;202(4):719-725
Radiation research 2024 Oct 1;202(4):719-725
Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition.
He X, Zhang J, Huang M, Wang J, Yang S, Yu X, Xu Y, Yang W
Cell death & disease 2024 Oct 1;15(10):718
Cell death & disease 2024 Oct 1;15(10):718
Acetate utilization promotes hormone therapy resistance in prostate cancer through neuroendocrine differentiation.
Gao D, Shen Y, Xu L, Sun Y, Hu H, Xu B, Wang Z, Xu H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101158
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101158
Metformin suppresses metabolic dysfunction-associated fatty liver disease by ferroptosis and apoptosis via activation of oxidative stress.
Li Z, Cui C, Xu L, Ding M, Wang Y
Free radical research 2024 Nov;58(11):686-701
Free radical research 2024 Nov;58(11):686-701
The small GTPase Cdc42 regulates shell field morphogenesis in a gastropod mollusk.
Liu X, Huan P, Liu B
Developmental biology 2024 Nov;515:7-17
Developmental biology 2024 Nov;515:7-17
Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats.
Wang Y, Fan Y, Zhou Y, Chen T, Xu S, Liu J, Li L
Molecular medicine reports 2024 Nov;30(5)
Molecular medicine reports 2024 Nov;30(5)
Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules.
Qi X, Zhao R, Yao X, Liu Q, Liu P, Zhu Z, Tu C, Gong W, Li X
International journal of biological macromolecules 2024 Nov;279(Pt 2):135274
International journal of biological macromolecules 2024 Nov;279(Pt 2):135274
A novel missense variant in HIKESHI: Clinical phenotype, in vitro functional testing, and potential for gene therapy.
Mallack EJ, Wang C, Kim JS, Ross ME
American journal of medical genetics. Part A 2024 Nov;194(11):e63790
American journal of medical genetics. Part A 2024 Nov;194(11):e63790
Cancer-Associated Endocrine Cells Participate in Pancreatic Carcinogenesis.
Chen Y, Yin X, Xu R, Ruze R, Song J, Yin C, Hu C, Wang C, Xu Q, Zhao Y
Gastroenterology 2024 Nov;167(6):1167-1182.e23
Gastroenterology 2024 Nov;167(6):1167-1182.e23
Astragaloside IV attenuates fatty acid-induced renal tubular injury in diabetic kidney disease by inhibiting fatty acid transport protein-2.
Wang J, Wang L, Feng X, Xu Y, Zhou L, Wang C, Wang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155991
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155991
All-trans retinoic acid inhibits glioblastoma progression and attenuates radiation-induced brain injury.
Fu M, Zhang Y, Peng B, Luo N, Zhang Y, Zhu W, Yang F, Chen Z, Zhang Q, Li Q, Chen X, Liu Y, Long G, Hu G, Peng X
JCI insight 2024 Nov 8;9(21)
JCI insight 2024 Nov 8;9(21)
TMEM232 is required for the formation of sperm flagellum and male fertility in mice.
Cai X, Zhang H, Kong S, Xu W, Zheng J, Wang N, He S, Li S, Shen Y, Wang K, Zhang Z, Cai H, Ma F, Bai S, Zhu F, Xiao F, Wang F
Cell death & disease 2024 Nov 8;15(11):806
Cell death & disease 2024 Nov 8;15(11):806
YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma.
Furutake Y, Yamaguchi K, Yamanoi K, Kitamura S, Takamatsu S, Taki M, Ukita M, Hosoe Y, Murakami R, Abiko K, Horie A, Hamanishi J, Baba T, Matsumura N, Mandai M
Molecular cancer therapeutics 2024 Nov 4;23(11):1652-1665
Molecular cancer therapeutics 2024 Nov 4;23(11):1652-1665
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.
Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC
Nature communications 2024 Nov 23;15(1):10159
Nature communications 2024 Nov 23;15(1):10159
Opposing roles for AMPK in regulating distinct mitophagy pathways.
Longo M, Bishnu A, Risiglione P, Montava-Garriga L, Cuenco J, Sakamoto K, MacKintosh C, Ganley IG
Molecular cell 2024 Nov 21;84(22):4350-4367.e9
Molecular cell 2024 Nov 21;84(22):4350-4367.e9
Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting.
Fan J, Wang Y, Wen M, Tong D, Wu K, Yan K, Jia P, Zhu Y, Liu Q, Zou H, Zhao P, Lu F, Yun C, Xue Y, Zhou Y, Cheng H
Molecular cell 2024 Nov 21;84(22):4297-4313.e7
Molecular cell 2024 Nov 21;84(22):4297-4313.e7
TonEBP degradation is essential for microtubule nucleation and regrowth.
Chinbold B, Kwon HM, Park R
Biochemical and biophysical research communications 2024 Nov 19;734:150791
Biochemical and biophysical research communications 2024 Nov 19;734:150791
Proteomic profiling of gliomas unveils immune and metabolism-driven subtypes with implications for anti-nucleotide metabolism therapy.
Zhang J, Sun R, Lyu Y, Liu C, Liu Y, Feng Y, Fu M, Wong PJC, Du Z, Qiu T, Zhang Y, Zhuang D, Qin Z, Yao Y, Zhu W, Guo T, Hua W, Yang H, Mao Y
Nature communications 2024 Nov 19;15(1):10005
Nature communications 2024 Nov 19;15(1):10005
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization.
Zhou Y, Yuan Y, Yao X, Wang L, Yao L, Tang D, Chen F, Li J
Biology direct 2024 Nov 18;19(1):117
Biology direct 2024 Nov 18;19(1):117
NEDD4L contributes to ferroptosis and cell growth inhibition in esophageal squamous cell carcinoma by facilitating xCT ubiquitination.
Chen Z, Wang W, Hou J, Gao C, Song M, Zhao Z, Guan R, Chen J, Wu H, Abdul Razak SR, Han T, Zhang J, Wang L, Ahmad NH, Li X
Cell death discovery 2024 Nov 18;10(1):473
Cell death discovery 2024 Nov 18;10(1):473
An interaction network of inner centriole proteins organised by POC1A-POC1B heterodimer crosslinks ensures centriolar integrity.
Sala C, Würtz M, Atorino ES, Neuner A, Partscht P, Hoffmann T, Eustermann S, Schiebel E
Nature communications 2024 Nov 14;15(1):9857
Nature communications 2024 Nov 14;15(1):9857
Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis.
Wei X, Long M, Fan Z, Hou Y, Yang L, Du Y
Scientific reports 2024 Nov 14;14(1):28032
Scientific reports 2024 Nov 14;14(1):28032
The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability.
Wang H, Liu X, Liu Y, Yang C, Ye Y, Yu X, Sheng N, Zhang S, Mao B, Ma P
eLife 2024 Nov 11;13
eLife 2024 Nov 11;13
The role of NLRP3 inflammasome-mediated neuroinflammation in chronic noise-induced impairment of learning and memory ability.
Ren Y, Wu K, He Y, Zhang H, Ma J, Li C, Ruan Y, Zhang J, Wen Y, Wu X, Chen S, Qiu H, Zhang Y, Zhou L, Ou Z, Liang J, Wang Z
Ecotoxicology and environmental safety 2024 Nov 1;286:117183
Ecotoxicology and environmental safety 2024 Nov 1;286:117183
Upregulated DNMT3a coupling with inhibiting p62-dependent autophagy contributes to NNK tumorigenicity in human bronchial epithelial cells.
Liu X, Wang J, Yang Z, Xie Q, Diao X, Yao X, Huang S, Chen R, Zhao Y, Li T, Jiang M, Lou Z, Huang C
Ecotoxicology and environmental safety 2024 Nov 1;286:117157
Ecotoxicology and environmental safety 2024 Nov 1;286:117157
Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation.
Meng Q, Zhang Y, Sun H, Yang X, Hao S, Liu B, Zhou H, Wang Y, Xu ZX
Redox biology 2024 May;71:103108
Redox biology 2024 May;71:103108
OTUD6A orchestrates complex modulation of TEAD4-mediated transcriptional programs.
Kim HJ, Choi Y, Lee Y, Hwangbo M, Kim J
FEBS letters 2024 May;598(9):1045-1060
FEBS letters 2024 May;598(9):1045-1060
METTL16-mediated N6-methyladenosine modification of Soga1 enables proper chromosome segregation and chromosomal stability in colorectal cancer.
Li J, Yang F, Wang Z, Zheng S, Zhang S, Wang C, He B, Wang JB, Wang H
Cell proliferation 2024 May;57(5):e13590
Cell proliferation 2024 May;57(5):e13590
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.
Wang Y, Gu YH, Ren KW, Xie X, Wang SH, Zhu XX, Wang L, Yang XL, Bi HL
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322
Epstein-Barr virus suppresses N(6)-methyladenosine modification of TLR9 to promote immune evasion.
Zhang X, Li Z, Peng Q, Liu C, Wu Y, Wen Y, Zheng R, Xu C, Tian J, Zheng X, Yan Q, Wang J, Ma J
The Journal of biological chemistry 2024 May;300(5):107226
The Journal of biological chemistry 2024 May;300(5):107226
TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1.
Heo H, Park H, Lee MS, Kim J, Kim J, Jung SY, Kim SK, Lee S, Chang J
Autophagy 2024 May;20(5):1098-1113
Autophagy 2024 May;20(5):1098-1113
DMC-siERCC2 hybrid nanoparticle enhances TRAIL sensitivity by inducing cell cycle arrest for glioblastoma treatment.
Song M, Wang T, Liu T, Lei T, Teng X, Peng Q, Zhu Q, Chen F, Zhao G, Li K, Qi L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116470
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116470
Postprandial Triglyceride-Rich Lipoproteins-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Inflammation in White Adipocytes.
Zhu L, Guo L, Xu J, Xiang Q, Tan Y, Tian F, Du X, Zhang S, Wen T, Liu L
The Journal of nutrition 2024 May;154(5):1619-1630
The Journal of nutrition 2024 May;154(5):1619-1630
Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells.
Rio-Vilariño A, Cenigaonandia-Campillo A, García-Bautista A, Mateos-Gómez PA, Schlaepfer MI, Del Puerto-Nevado L, Aguilera O, García-García L, Galeano C, de Miguel I, Serrano-López J, Baños N, Fernández-Aceñero MJ, Lacal JC, Medico E, García-Foncillas J, Cebrián A
British journal of cancer 2024 May;130(8):1402-1413
British journal of cancer 2024 May;130(8):1402-1413
Melatonin suppresses atherosclerosis by ferroptosis inhibition via activating NRF2 pathway.
Tao Y, Zhao Q, Lu C, Yong W, Xu M, Wang Z, Leng X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23678
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23678
Exercise activates interferon response of the liver via Gpld1 to enhance antiviral innate immunity.
Ren T, He J, Zhang T, Niu A, Yuan Y, Zuo Y, Miao Y, Zhang H, Zang L, Qiao C, Cao X, Yang X, Zheng Z, Xu Y, Wu D, Zheng H
Science advances 2024 May 31;10(22):eadk5011
Science advances 2024 May 31;10(22):eadk5011
A ZBP1 isoform blocks ZBP1-mediated cell death.
Cai ZY, Wu P, Liang H, Xie YZ, Zhang BX, He CL, Yang CR, Li H, Mo W, Yang ZH
Cell reports 2024 May 28;43(5):114221
Cell reports 2024 May 28;43(5):114221
Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.
Chen KD, Wang KL, Chen C, Zhu YJ, Tang WW, Wang YJ, Chen ZP, He LH, Chen YG, Zhang W
World journal of gastroenterology 2024 May 28;30(20):2709-2725
World journal of gastroenterology 2024 May 28;30(20):2709-2725
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.
Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC
bioRxiv : the preprint server for biology 2024 May 25;
bioRxiv : the preprint server for biology 2024 May 25;
Melatonin Ameliorates Post-Stroke Cognitive Impairment in Mice by Inhibiting Excessive Mitophagy.
Shi Y, Fang Q, Hu Y, Mi Z, Luo S, Gan Y, Yuan S
Cells 2024 May 18;13(10)
Cells 2024 May 18;13(10)
A cingulate-hippocampal circuit mediates early depressive-like behavior in the mouse model of Alzheimer disease.
Chen Y, Peng H, Zhuang K, Xie W, Li C, Chen M, Xue J, Huang X, Zou T, Sun H, Lei A, Wang Y, Can D, Li H, Yuan T, Zhang J
iScience 2024 May 17;27(5):109778
iScience 2024 May 17;27(5):109778
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.
Wu A, Zhong C, Song X, Yuan W, Tang M, Shu T, Huang H, Yang P, Liu Q
iScience 2024 May 17;27(5):109510
iScience 2024 May 17;27(5):109510
Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.
Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C
Science advances 2024 May 17;10(20):eadi7024
Science advances 2024 May 17;10(20):eadi7024
Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers.
Mao C, Lei G, Horbath A, Wang M, Lu Z, Yan Y, Liu X, Kondiparthi L, Chen X, Cheng J, Li Q, Xu Z, Zhuang L, Fang B, Marszalek JR, Poyurovsky MV, Olszewski K, Gan B
Molecular cell 2024 May 16;84(10):1964-1979.e6
Molecular cell 2024 May 16;84(10):1964-1979.e6
An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins.
Ji J, Cui MK, Zou R, Wu MZ, Ge MX, Li J, Zhang ZR
Molecular cell 2024 May 16;84(10):1917-1931.e15
Molecular cell 2024 May 16;84(10):1917-1931.e15
Cr(VI) induces ferroptosis in DF-1 cells by simultaneously perturbing iron homeostasis of ferritinophagy and mitophagy.
Song K, Liu X, Xu H, Li M, Zheng Q, Qi C, Wang X, Liu Y, Zheng P, Liu J
The Science of the total environment 2024 May 15;925:171818
The Science of the total environment 2024 May 15;925:171818
Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells.
Haight JA, Koppenhafer SL, Geary EL, Gordon DJ
bioRxiv : the preprint server for biology 2024 May 15;
bioRxiv : the preprint server for biology 2024 May 15;
Expanding the adenovirus toolbox: reporter viruses for studying the dynamics of human adenovirus replication.
King CR, Dodge MJ, MacNeil KM, Tessier TM, Mymryk JS, Mehle A
Journal of virology 2024 May 14;98(5):e0020724
Journal of virology 2024 May 14;98(5):e0020724
Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma.
Shi Y, Wang Z, Shao Y, Guang Q, Zhang J, Liu B, Wu C, Wang Y, Sui P
Biochemical and biophysical research communications 2024 May 14;708:149808
Biochemical and biophysical research communications 2024 May 14;708:149808
Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis.
Zhang Q, Chen C, Zou X, Wu W, Di Y, Li N, Fu A
Cell death & disease 2024 May 13;15(5):329
Cell death & disease 2024 May 13;15(5):329
Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity.
Parlakgül G, Pang S, Artico LL, Min N, Cagampan E, Villa R, Goncalves RLS, Lee GY, Xu CS, Hotamışlıgil GS, Arruda AP
Nature communications 2024 May 10;15(1):3982
Nature communications 2024 May 10;15(1):3982
TH-4000, a hypoxia-activated pan-HER inhibitor, shows excellent preclinical efficacy for the treatment of HER2(+) breast cancer.
Shao X, Yang D, Shan L, Yan X, Xu D, Li L, Sun Y, Yu Q, Zhou H, Ding Y, Tang J
Archives of toxicology 2024 Mar;98(3):865-881
Archives of toxicology 2024 Mar;98(3):865-881
Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway.
Liang W, Liu M, Su Y, Wen Y, Wang L, Shan J, Zhao J, Xie K, Wang J
IUBMB life 2024 Mar;76(3):140-160
IUBMB life 2024 Mar;76(3):140-160
Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways.
Liu W, Han J, Yang Q, Xia L, Chen C, Song J, Cai Y
Biochemistry and biophysics reports 2024 Mar;37:101591
Biochemistry and biophysics reports 2024 Mar;37:101591
Novel compound heterozygous variants in FANCI cause premature ovarian insufficiency.
Cao L, He X, Ren J, Wen C, Guo T, Yang F, Qin Y, Chen ZJ, Zhao S, Yang Y
Human genetics 2024 Mar;143(3):357-369
Human genetics 2024 Mar;143(3):357-369
Dietary Restriction Improves Perioperative Neurocognitive Disorders by Inhibiting Neuroinflammation and Gut Microbial Dysbiosis.
Ren L, Liang H, Zhu L, Yang X, Zhang H, Sun N, Huang D, Feng J, Wu Y, Xiong L, Ke X, Li M, Zhang A
Neuroscience 2024 Mar 5;540:48-67
Neuroscience 2024 Mar 5;540:48-67
Secretome from Magnetically Stimulated Muscle Exhibits Anticancer Potency: Novel Preconditioning Methodology Highlighting HTRA1 Action.
Tai YK, Iversen JN, Chan KKW, Fong CHH, Abdul Razar RB, Ramanan S, Yap LYJ, Yin JN, Toh SJ, Wong CJK, Koh PFA, Huang RYJ, Franco-Obregón A
Cells 2024 Mar 5;13(5)
Cells 2024 Mar 5;13(5)
Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females.
Vermehren-Schmaedick A, Joshi S, Wagoner W, Norgard MA, Packwood W, Diba P, Mendez H, Fedorov LM, Rakshe S, Park B, Marks DL, Grossberg A, Luoh SW
Endocrinology 2024 Mar 29;165(5)
Endocrinology 2024 Mar 29;165(5)
Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes.
Hou L, Liu W, Zhang H, Li R, Liu M, Shi H, Wu L
Genome biology 2024 Mar 26;25(1):80
Genome biology 2024 Mar 26;25(1):80
PELI1: key players in the oncogenic characteristics of pancreatic Cancer.
Fei X, Zhu C, Liu P, Liu S, Ren L, Lu R, Hou J, Gao Y, Wang X, Pan Y
Journal of experimental & clinical cancer research : CR 2024 Mar 25;43(1):91
Journal of experimental & clinical cancer research : CR 2024 Mar 25;43(1):91
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q
Cell death & disease 2024 Mar 23;15(3):233
Cell death & disease 2024 Mar 23;15(3):233
G-quadruplexes on chromosomal DNA negatively regulates topoisomerase 1 activity.
Liang HT, Yan JY, Yao HJ, Zhang XN, Xing ZM, Liu L, Chen YQ, Li GR, Huang J, He YD, Zheng KW
Nucleic acids research 2024 Mar 21;52(5):2142-2156
Nucleic acids research 2024 Mar 21;52(5):2142-2156
The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.
Jin H, Huang X, Pan Q, Ma N, Xie X, Wei Y, Yu F, Wen W, Zhang B, Zhang P, Chen X, Wang J, Liu RY, Lin J, Meng X, Lee MH
Nature communications 2024 Mar 21;15(1):2551
Nature communications 2024 Mar 21;15(1):2551
An alpha-herpesvirus employs host HEXIM1 to promote viral transcription.
Wu Y, Sun A, Yang Q, Wang M, Tian B, Yang Q, Jia R, Chen S, Ou X, Huang J, Sun D, Zhu D, Liu M, Zhang S, Zhao X-X, He Y, Wu Z, Cheng A
Journal of virology 2024 Mar 19;98(3):e0139223
Journal of virology 2024 Mar 19;98(3):e0139223
CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response.
Cen Q, Chen J, Guo J, Chen M, Wang H, Wu S, Zhang H, Xie X, Li Y
Journal of translational medicine 2024 Mar 14;22(1):278
Journal of translational medicine 2024 Mar 14;22(1):278
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.
Ren LK, Lu RS, Fei XB, Chen SJ, Liu P, Zhu CH, Wang X, Pan YZ
Journal of cancer research and clinical oncology 2024 Mar 14;150(3):127
Journal of cancer research and clinical oncology 2024 Mar 14;150(3):127
DDX4 enhances antiviral activity of type I interferon by disrupting interaction of USP7/SOCS1 and promoting degradation of SOCS1.
Miao Y, Zhang T, Guan M, Zhao Q, Zhang R, Liu X, Ma T, Ren T, Zheng Z, He W, Tian W, Cui Q, Zhai X, Zuo Y, Zhu H, Zheng H, Yuan Y
mBio 2024 Mar 13;15(3):e0321323
mBio 2024 Mar 13;15(3):e0321323
Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion.
Planas D, Staropoli I, Michel V, Lemoine F, Donati F, Prot M, Porrot F, Guivel-Benhassine F, Jeyarajah B, Brisebarre A, Dehan O, Avon L, Bolland WH, Hubert M, Buchrieser J, Vanhoucke T, Rosenbaum P, Veyer D, Péré H, Lina B, Trouillet-Assant S, Hocqueloux L, Prazuck T, Simon-Loriere E, Schwartz O
Nature communications 2024 Mar 13;15(1):2254
Nature communications 2024 Mar 13;15(1):2254
C-Myc/H19/miR-29b axis downregulates nerve/glial (NG)2 expression in glioblastoma multiforme.
Boewe AS, Wrublewsky S, Hoppstädter J, Götz C, Kiemer AK, Menger MD, Laschke MW, Ampofo E
Molecular therapy. Nucleic acids 2024 Mar 12;35(1):102120
Molecular therapy. Nucleic acids 2024 Mar 12;35(1):102120
Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo.
Tang FL, Xie LW, Tang LF, Lu HY, Zhu RQ, Wang DF, Tian Y, Cai S, Li M
International immunopharmacology 2024 Mar 10;129:111637
International immunopharmacology 2024 Mar 10;129:111637
Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation.
Geng M, Shao Q, Fu J, Gu J, Feng L, Zhao L, Liu C, Mu J, Zhang X, Zhao M, Guo X, Song C, Li Y, Wang H, Wang C
Translational psychiatry 2024 Mar 1;14(1):130
Translational psychiatry 2024 Mar 1;14(1):130
TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response.
Pang SG, Zhang X, Li ZX, He LF, Chen F, Liu ML, Huang YZ, Mo JM, Luo KL, Xiao JJ, Zhu F
Current medical science 2024 Jun;44(3):545-553
Current medical science 2024 Jun;44(3):545-553
Ring finger protein 216 loss-of-function induces white matter hyperintensities by inhibiting oligodendroglia proliferation.
Xu W, Chen K, Yuan Y, Guo M, Dong Q, Cui M
Cell biochemistry and function 2024 Jun;42(4):e4057
Cell biochemistry and function 2024 Jun;42(4):e4057
BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury.
Liu H, Li C, Zhang X, Chen H, Zhang Q, Zeng Y, Zheng S, Zou J, Zhao Y, Zheng X, Huang G, Zeng Q
Experimental neurology 2024 Jun;376:114726
Experimental neurology 2024 Jun;376:114726
Positron emission tomography guided synergistic treatment of melanoma using multifunctional zirconium-hematoporphyrin nanosonosensitizers.
Jiao X, Li X, Du Y, Cong Y, Yang S, Chen D, Zhang T, Feng M, Hong H
Journal of controlled release : official journal of the Controlled Release Society 2024 Jun;370:95-109
Journal of controlled release : official journal of the Controlled Release Society 2024 Jun;370:95-109
Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
Katayama K, Ito J, Murakami R, Yamashita A, Sasajima H, Narahashi S, Chiba J, Yamamoto I, Fujii W, Tochigi Y, Suzuki H
Mammalian genome : official journal of the International Mammalian Genome Society 2024 Jun;35(2):149-159
Mammalian genome : official journal of the International Mammalian Genome Society 2024 Jun;35(2):149-159
CGI1746 targets σ(1)R to modulate ferroptosis through mitochondria-associated membranes.
Zhang Z, Zhou H, Gu W, Wei Y, Mou S, Wang Y, Zhang J, Zhong Q
Nature chemical biology 2024 Jun;20(6):699-709
Nature chemical biology 2024 Jun;20(6):699-709
Integrated transcriptome and metabolome study reveal the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease.
Zhang J, Chen F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116701
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116701
SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.
Xu Y, Duan S, Ye W, Zheng Z, Zhang J, Gao Y, Ye S
Thoracic cancer 2024 Jun;15(17):1369-1384
Thoracic cancer 2024 Jun;15(17):1369-1384
Moracin D suppresses cell growth and induces apoptosis via targeting the XIAP/PARP1 axis in pancreatic cancer.
Zhong X, Ke X, Yang H, Ye X, Li C, Pan J, Ran W, Wang F, Cui H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155527
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155527
O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy.
Dong W, Imdad L, Xu S, Wang Y, Liu C, Song S, Li Z, Kong Y, Kong L, Ren X
International journal of molecular sciences 2024 Jun 6;25(11)
International journal of molecular sciences 2024 Jun 6;25(11)
Mecp2 Deficiency in Peripheral Sensory Neuron Improves Cognitive Function by Enhancing Hippocampal Dendritic Spine Densities in Mice.
Feng Y, Wang J, Liu J, Zhou Y, Jiang Y, Zhou W, Wu F, Liu X, Luo L
Cells 2024 Jun 6;13(11)
Cells 2024 Jun 6;13(11)
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Duan WL, Ma YP, Wang XJ, Ma CS, Han B, Sheng ZM, Dong H, Zhang LY, Li PA, Zhang BG, He MT
European journal of pharmacology 2024 Jun 5;972:176553
European journal of pharmacology 2024 Jun 5;972:176553
Phosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma.
Liu Y, Shao K, Yang W, Shen Q, Lu M, Shao Z, Chu S, Wang Y, Wang X, Chen X, Bai J, Wu X
Cell death & disease 2024 Jun 5;15(6):395
Cell death & disease 2024 Jun 5;15(6):395
CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer.
Zhong C, Jiang WJ, Yao Y, Li Z, Li Y, Wang S, Wang X, Zhu W, Wu S, Wang J, Fan S, Ma S, Liu Y, Zhang H, Zhao W, Zhao L, Feng Y, Li Z, Guo R, Yu L, Pei F, Hu J, Feng X, Yang Z, Yang Z, Yang X, Hou Y, Zhang D, Xu D, Sheng R, Li Y, Liu L, Wu HJ, Huang J, Fei T
Nature communications 2024 Jun 29;15(1):5502
Nature communications 2024 Jun 29;15(1):5502
IGF2BP2-Shox2 axis regulates hippocampal-neuronal senescence to alleviate microgravity-induced recognition disturbance.
Zhao Y, Ji G, Zhou S, Cai S, Li K, Zhang W, Zhang C, Yan N, Zhang S, Li X, Song B, Qu L
iScience 2024 Jun 21;27(6):109917
iScience 2024 Jun 21;27(6):109917
Compositionally unique mitochondria in filopodia support cellular migration.
Marlar-Pavey M, Tapias-Gomez D, Mettlen M, Friedman JR
bioRxiv : the preprint server for biology 2024 Jun 21;
bioRxiv : the preprint server for biology 2024 Jun 21;
Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients.
Li H, Wu J, Xu Q, Pang Y, Gu Y, Wang M, Cheng X
Journal of translational medicine 2024 Jun 18;22(1):577
Journal of translational medicine 2024 Jun 18;22(1):577
EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease.
Kan S, Hou Q, Shi J, Zhang M, Xu F, Liu Z, Jiang S
Cell death discovery 2024 Jun 15;10(1):289
Cell death discovery 2024 Jun 15;10(1):289
Peptide-encoding gene transfer to modulate intracellular protein-protein interactions.
Taya T, Kami D, Teruyama F, Matoba S, Gojo S
Molecular therapy. Methods & clinical development 2024 Jun 13;32(2):101226
Molecular therapy. Methods & clinical development 2024 Jun 13;32(2):101226
Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.
Saunders N, Monel B, Cayet N, Archetti L, Moreno H, Jeanne A, Marguier A, Buchrieser J, Wai T, Schwartz O, Fréchin M
Nature communications 2024 Jun 11;15(1):4996
Nature communications 2024 Jun 11;15(1):4996
COL8A1 is a potential prognostic biomarker associated with migration, proliferation, and tumor microenvironment in glioma.
Liu M, Liang W, Su Y, Wen Y, Qi J, Wang L, Su S, Zhao J, Shan J, Wang J
Experimental cell research 2024 Jun 1;439(1):114076
Experimental cell research 2024 Jun 1;439(1):114076
Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer.
Dong S, Zhang M, Cheng Z, Zhang X, Liang W, Li S, Li L, Xu Q, Song S, Liu Z, Yang G, Zhao X, Tao Z, Liang S, Wang K, Zhang G, Hu S
Redox biology 2024 Jul;73:103207
Redox biology 2024 Jul;73:103207
YBX1 as a prognostic biomarker and potential therapeutic target in hepatocellular carcinoma: A comprehensive investigation through bioinformatics analysis and in vitro study.
Li Z, Lu W, Yin F, Huang A
Translational oncology 2024 Jul;45:101965
Translational oncology 2024 Jul;45:101965
A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomes.
Shen D, Zhang G, Weng X, Liu R, Liu Z, Sheng X, Zhang Y, Liu Y, Mu Y, Zhu Y, Sun E, Zhang J, Li F, Xia C, Ge J, Liu Z, Bu Z, Zhao D
PLoS pathogens 2024 Jul;20(7):e1012256
PLoS pathogens 2024 Jul;20(7):e1012256
Spermatogenic cell-specific type 1 hexokinase (HK1S) is essential for capacitation-associated increase in tyrosine phosphorylation and male fertility in mice.
Tian Y, Chen X, Pu J, Liang Y, Li W, Xu X, Tan X, Yu S, Shao T, Ma Y, Wang B, Chen Y, Li Y
PLoS genetics 2024 Jul;20(7):e1011357
PLoS genetics 2024 Jul;20(7):e1011357
PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α.
Wei Y, Zhang D, Shi H, Qian H, Chen H, Zeng Q, Jin F, Ye Y, Ou Z, Guo M, Guo B, Chen T
Genes & diseases 2024 Jul;11(4):101041
Genes & diseases 2024 Jul;11(4):101041
Oridonin attenuates liver ischemia-reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis.
Wu XY, Zhao MJ, Liao W, Liu T, Liu JY, Gong JH, Lai X, Xu XS
Cellular immunology 2024 Jul-Aug;401-402:104838
Cellular immunology 2024 Jul-Aug;401-402:104838
LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.
Wu HH, Du JM, Liu P, Meng FL, Li YY, Li WJ, Wang SX, Du NL, Zheng Y, Zhang L, Wang HY, Liu YR, Song CH, Ni X, Li Y, Su GH
International immunopharmacology 2024 Jul 30;136:112338
International immunopharmacology 2024 Jul 30;136:112338
Engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer.
Smith TJ, Elmore ZC, Fusco RM, Hull JA, Rosales A, Martinez M, Tarantal AF, Asokan A
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Jul 3;32(7):2080-2093
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Jul 3;32(7):2080-2093
The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH.
Shen X, Zheng W, Du X, Chen Y, Song X, Yang L, Yuan Q
Scientific reports 2024 Jul 26;14(1):17232
Scientific reports 2024 Jul 26;14(1):17232
SIL1 improves cognitive impairment in APP23/PS45 mice by regulating amyloid precursor protein processing and Aβ generation.
Wang Q, Jiang Y, Meng Z, Dong X, Hu D, Ji L, Zhou W, Song W
Zoological research 2024 Jul 18;45(4):845-856
Zoological research 2024 Jul 18;45(4):845-856
Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice.
Wang N, Zhang S, Langfelder P, Ramanathan L, Plascencia M, Gao F, Vaca R, Gu X, Deng L, Dionisio LE, Prasad BC, Vogt T, Horvath S, Aaronson JS, Rosinski J, Yang XW
bioRxiv : the preprint server for biology 2024 Jul 15;
bioRxiv : the preprint server for biology 2024 Jul 15;
Pan-cancer transcriptome analysis reveals widespread regulation through alternative tandem transcription initiation.
Zhao Z, Chen Y, Zou X, Lin L, Zhou X, Cheng X, Yang G, Xu Q, Gong L, Li L, Ni T
Science advances 2024 Jul 12;10(28):eadl5606
Science advances 2024 Jul 12;10(28):eadl5606
FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
Wang L, Mao X, Yu X, Su J, Li Z, Chen Z, Ren Y, Huang H, Wang W, Zhao C, Hu Y
Cancer letters 2024 Jul 1;593:216841
Cancer letters 2024 Jul 1;593:216841
AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice.
Zhou H, Fick K, Patel V, Hilton LR, Kim HW, Bagi Z, Weintraub NL, Chen W
American journal of physiology. Endocrinology and metabolism 2024 Jul 1;327(1):E69-E80
American journal of physiology. Endocrinology and metabolism 2024 Jul 1;327(1):E69-E80
Regulating effect of miR-132-3p on the changes of MAPK pathway in rat brains and SH-SY5Y cells exposed to excessive fluoride by targeting expression of MAPK1.
He WW, Zeng XX, Qi XL, Gui CZ, Liao W, Tu X, Deng J, Dong YT, Hong W, He Y, Xiao Y, Guan ZZ
Ecotoxicology and environmental safety 2024 Jul 1;279:116467
Ecotoxicology and environmental safety 2024 Jul 1;279:116467
Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging.
Li M, Guo H, Carey M, Huang C
Nature aging 2024 Jan;4(1):62-79
Nature aging 2024 Jan;4(1):62-79
Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.
Li S, Wang M, Van Sciver N, Szymula A, Tumuluri VS, George A, Ramachandran A, Raina K, Costa CN, Zhao B, Kazemian M, Simas JP, Kaye KM
PLoS pathogens 2024 Jan;20(1):e1011907
PLoS pathogens 2024 Jan;20(1):e1011907
Grape seed-derived procyanidin inhibits glyphosate-induced hepatocyte ferroptosis via enhancing crosstalk between Nrf2 and FGF12.
Liu J, Li K, Li S, Yang G, Lin Z, Miao Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155278
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155278
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Cai Y, Yang H, Wan Z, Chen PY, Wang ZB, Guo JJ, Wang D, Wang F, Zhang Y
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
Curcumin suppresses metastasis, invasion, and proliferation in osteosarcoma cells by regulating the EGFR/Src signaling axis.
Liu H, Li Z, Xu B, Li Z, Yang X, Luo J
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241308082
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241308082
Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics.
Xie LW, Cai S, Lu HY, Tang FL, Zhu RQ, Tian Y, Li M
Gut microbes 2024 Jan-Dec;16(1):2347722
Gut microbes 2024 Jan-Dec;16(1):2347722
Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease.
Wang Q, Guo S, Hu D, Dong X, Meng Z, Jiang Y, Feng Z, Zhou W, Song W
Neuroscience 2024 Jan 9;536:1-11
Neuroscience 2024 Jan 9;536:1-11
Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations.
Tsai MH, Ke HC, Lin WC, Nian FS, Huang CW, Cheng HY, Hsu CS, Granata T, Chang CH, Castellotti B, Lin SY, Doniselli FM, Lu CJ, Franceschetti S, Ragona F, Hou PS, Canafoglia L, Tung CY, Lee MH, Wang WJ, Tsai JW
Acta neuropathologica 2024 Jan 9;147(1):13
Acta neuropathologica 2024 Jan 9;147(1):13
Integrating network pharmacology and bioinformatics to explore and experimentally verify the regulatory effect of Buyang Huanwu decoction on glycolysis and angiogenesis after cerebral infarction.
Tian F, Yi J, Liu Y, Chen B, Wang X, Ouyang Y, Liu J, Tang Y, Long H, Liu B
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117218
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117218
Porcine Intestinal Mucosal Peptides Target Macrophage-Modulated Inflammation and Alleviate Intestinal Homeostasis in Dextrose Sodium Sulfate-Induced Colitis in Mice.
Wang Y, Xie Z, Wu X, Du L, Chong Z, Liu R, Han J
Foods (Basel, Switzerland) 2024 Jan 3;13(1)
Foods (Basel, Switzerland) 2024 Jan 3;13(1)
2.7 Å cryo-EM structure of human telomerase H/ACA ribonucleoprotein.
Ghanim GE, Sekne Z, Balch S, van Roon AM, Nguyen THD
Nature communications 2024 Jan 25;15(1):746
Nature communications 2024 Jan 25;15(1):746
A nanobody inhibiting porcine reproductive and respiratory syndrome virus replication via blocking self-interaction of viral nucleocapsid protein.
Duan H, Chen X, Zhang Z, Zhang Z, Li Z, Wang X, Zhao J, Nan Y, Liu B, Zhang A, Sun Y, Zhao Q
Journal of virology 2024 Jan 23;98(1):e0131923
Journal of virology 2024 Jan 23;98(1):e0131923
The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping.
Maghe C, Trillet K, André-Grégoire G, Kerhervé M, Merlet L, Jacobs KA, Schauer K, Bidère N, Gavard J
Cell reports 2024 Jan 23;43(1):113631
Cell reports 2024 Jan 23;43(1):113631
Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma.
Chien MH, Yang YC, Ho KH, Ding YF, Chen LH, Chiu WK, Chen JQ, Tung MC, Hsiao M, Lee WJ
Cell death & disease 2024 Jan 23;15(1):82
Cell death & disease 2024 Jan 23;15(1):82
Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.
Cheng Z, Huang H, Li M, Chen Y
iScience 2024 Jan 19;27(1):108645
iScience 2024 Jan 19;27(1):108645
siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells.
Zhang B, Ayra-Pardo C, Liu X, Song M, Li D, Kan Y
Insects 2024 Jan 19;15(1)
Insects 2024 Jan 19;15(1)
Macrophage-expressed SRA ameliorates alcohol-induced liver injury by suppressing S-glutathionylation of Notch1 via recruiting thioredoxin.
Li L, Luo J, Zhu Z, Wang P, Xu Q, Chang B, Wang D, Yu L, Lu X, Zhou J, Chen Q, Zuo D
Journal of leukocyte biology 2024 Jan 19;115(2):322-333
Journal of leukocyte biology 2024 Jan 19;115(2):322-333
Identification of a basement membrane gene signature for predicting prognosis and estimating the tumor immune microenvironment in prostate cancer.
Xie T, Fu DJ, Li KJ, Guo JD, Xiao ZM, Li Z, Zhao SC
Aging 2024 Jan 17;16(2):1581-1604
Aging 2024 Jan 17;16(2):1581-1604
Cadmium exposure induces pyroptosis of TM4 cells through oxidative stress damage and inflammasome activation.
Zhou J, Zhang Y, Zeng L, Wang X, Xiang W, Su P
Ecotoxicology and environmental safety 2024 Jan 15;270:115930
Ecotoxicology and environmental safety 2024 Jan 15;270:115930
Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer.
Ma Q, Zeng Q, Wang K, Qian M, Li J, Wang H, Zhang H, Jiang J, Chen Z, Huang W
International journal of molecular sciences 2024 Jan 15;25(2)
International journal of molecular sciences 2024 Jan 15;25(2)
Network pharmacology and transcriptomics to determine Danggui Yifei Decoction mechanism of action for the treatment of chronic lung injury.
Guo J, Liang J, Guo Z, Bai X, Zhang H, Zhang N, Wang H, Chen Q, Li W, Dong R, Ge D, Yu X, Cui X
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116873
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116873
S-Adenosylmethionine Inhibits the Proliferation of Retinoblastoma Cell Y79, Induces Apoptosis and Cell Cycle Arrest of Y79 Cells by Inhibiting the Wnt2/β-Catenin Pathway.
Liu M, Mobet Y, Shen H
Archivum immunologiae et therapiae experimentalis 2024 Jan 1;72(1)
Archivum immunologiae et therapiae experimentalis 2024 Jan 1;72(1)
Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function.
Wang L, Hu L, Wang X, Geng Z, Wan M, Hao J, Liu H, Fan Y, Xu T, Li Z
Molecular metabolism 2024 Feb;80:101878
Molecular metabolism 2024 Feb;80:101878
Regulatory Effects and Mechanisms of L-Theanine on Neurotransmitters via Liver-Brain Axis Under a High Protein Diet.
Xu W, Song Y, Xiao W, Gong Z
Molecular neurobiology 2024 Feb;61(2):783-798
Molecular neurobiology 2024 Feb;61(2):783-798
The role and mechanism of RIPK1 in vascular endothelial dysfunction in chronic kidney disease.
Wang C, Chen H, Su H, Sheng Q, Lang Y, Yu Q, Lv Z, Wang R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb;38(2):e23446
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb;38(2):e23446
Icariside II prevents kidney fibrosis development in chronic kidney disease by promoting fatty acid oxidation.
Wang M, Wang J, Wang L, Feng X, Qian Y, Ye C, Wang C
Phytotherapy research : PTR 2024 Feb;38(2):839-855
Phytotherapy research : PTR 2024 Feb;38(2):839-855
The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
Jian F, Wang S, Tian R, Wang Y, Li C, Li Y, Wang S, Fang C, Ma C, Rong Y
Cell research 2024 Feb;34(2):151-168
Cell research 2024 Feb;34(2):151-168
Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain.
Zhang ZQ, Lu Y, Zhang H, Dong SH, Wu YT, Wang SN, Huang AH, Jiang QS, Yin SM
CNS neuroscience & therapeutics 2024 Feb;30(2):e14365
CNS neuroscience & therapeutics 2024 Feb;30(2):e14365
Echinococcus granulosus cyst fluid inhibits the type I interferon response by promoting ROS in macrophages.
Fu C, Yang C, Ni C, Wang L, Hou J
Acta tropica 2024 Feb;250:107101
Acta tropica 2024 Feb;250:107101
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Xing D, Jin Y, Sun D, Liu Y, Cai B, Gao C, Cui Y, Jin B
Archives of gerontology and geriatrics 2024 Feb;117:105274
Archives of gerontology and geriatrics 2024 Feb;117:105274
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.
Pinto LM, Pailas A, Bondarchenko M, Sharma AB, Neumann K, Rizzo AJ, Jeanty C, Nicot N, Racca C, Graham MK, Naughton C, Liu Y, Chen CL, Meakin PJ, Gilbert N, Britton S, Meeker AK, Heaphy CM, Larminat F, Van Dyck E
Nucleic acids research 2024 Feb 9;52(3):1136-1155
Nucleic acids research 2024 Feb 9;52(3):1136-1155
RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination.
Li Y, Wan LP, Song NN, Ding YQ, Zhao S, Niu J, Mao B, Sheng N, Ma P
Science advances 2024 Feb 9;10(6):eadk3931
Science advances 2024 Feb 9;10(6):eadk3931
Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion.
Planas D, Staropoli I, Michel V, Lemoine F, Donati F, Prot M, Porrot F, Guivel-Benhassine F, Jeyarajah B, Brisebarre A, Dehan O, Avon L, Boland WH, Hubert M, Buchrieser J, Vanhoucke T, Rosenbaum P, Veyer D, Péré H, Lina B, Trouillet-Assant S, COVID-SER study group, Hocqueloux L, Prazuck T, Simon-Loriere E, Schwartz O
bioRxiv : the preprint server for biology 2024 Feb 9;
bioRxiv : the preprint server for biology 2024 Feb 9;
N4-acetylcytidine modifies primary microRNAs for processing in cancer cells.
Zhang H, Lu R, Huang J, Li L, Cao Y, Huang C, Chen R, Wang Y, Huang J, Zhao X, Yu J
Cellular and molecular life sciences : CMLS 2024 Feb 3;81(1):73
Cellular and molecular life sciences : CMLS 2024 Feb 3;81(1):73
Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome.
Li S, Liu B, Tan M, Juillard F, Szymula A, Álvarez ÁL, Van Sciver N, George A, Ramachandran A, Raina K, Tumuluri VS, Costa CN, Simas JP, Kaye KM
Nucleic acids research 2024 Feb 28;52(4):1814-1829
Nucleic acids research 2024 Feb 28;52(4):1814-1829
Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization.
Kuo CH, Lee GH, Wu HL, Huang JY, Tang MJ
Proceedings of the National Academy of Sciences of the United States of America 2024 Feb 27;121(9):e2315894121
Proceedings of the National Academy of Sciences of the United States of America 2024 Feb 27;121(9):e2315894121
ALYREF-JunD-SLC7A5 axis promotes pancreatic ductal adenocarcinoma progression through epitranscriptome-metabolism reprogramming and immune evasion.
Meng Q, Xie Y, Sun K, He L, Wu H, Zhang Q, Liang T
Cell death discovery 2024 Feb 24;10(1):97
Cell death discovery 2024 Feb 24;10(1):97
Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways.
Lye PY, Shiraki C, Fukushima Y, Takaki K, Liew MWO, Yamamoto M, Wakabayashi K, Mori H, Kotani E
iScience 2024 Feb 16;27(2):108853
iScience 2024 Feb 16;27(2):108853
Andrographolide derivative Andro-III modulates neuroinflammation and attenuates neuropathological changes of Alzheimer's disease via GSK-3β/NF-κB/CREB pathway.
Hu M, Zheng M, Wang C, Li Q, Li J, Zhou X, Ying X, Quan S, Gu L, Zhang X
European journal of pharmacology 2024 Feb 15;965:176305
European journal of pharmacology 2024 Feb 15;965:176305
ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
He Y, Gang B, Zhang M, Bai Y, Wan Z, Pan J, Liu J, Liu G, Gu W
International immunopharmacology 2024 Feb 15;128:111535
International immunopharmacology 2024 Feb 15;128:111535
PTEN Mediates the Silencing of Unintegrated HIV-1 DNA.
Phan AT, Zhu Y
Viruses 2024 Feb 14;16(2)
Viruses 2024 Feb 14;16(2)
Progesterone Receptor Membrane Component 1 Regulates Cellular Stress Responses and Inflammatory Pathways in Chronic Neuroinflammatory Conditions.
Jo SL, Hong EJ
Antioxidants (Basel, Switzerland) 2024 Feb 13;13(2)
Antioxidants (Basel, Switzerland) 2024 Feb 13;13(2)
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells.
Zhang F, Hao Y, Yang N, Liu M, Luo Y, Zhang Y, Zhou J, Liu H, Li J
BMC cancer 2024 Feb 12;24(1):198
BMC cancer 2024 Feb 12;24(1):198
Metabolites that feed upper glycolytic branches support glucose independent human cytomegalovirus replication.
Mokry RL, Purdy JG
bioRxiv : the preprint server for biology 2024 Feb 12;
bioRxiv : the preprint server for biology 2024 Feb 12;
Ferritin loss in astrocytes reduces spinal cord oxidative stress and demyelination in the experimental autoimmune encephalomyelitis (EAE) model.
Smith Z, Cheli VT, Angeliu CG, Wang C, Denaroso GE, Tumuluri SG, Corral J, Garbarini K, Paez PM
Glia 2024 Dec;72(12):2327-2343
Glia 2024 Dec;72(12):2327-2343
Peroxynitrite-Triggered Carbon Monoxide Donor Improves Ischemic Stroke Outcome by Inhibiting Neuronal Apoptosis and Ferroptosis.
Guo XJ, Huang LY, Gong ST, Li M, Wang W, Chen J, Zhang YD, Lu X, Chen X, Luo L, Yang Y, Luo X, Qi SH
Molecular neurobiology 2024 Dec;61(12):10629-10644
Molecular neurobiology 2024 Dec;61(12):10629-10644
Pseudorabies virus UL13 primes inflammatory response through downregulating heat shock factor 1.
Zhang WJ, Feng H, Zhang MM, Liu JS, Li LT, Chen HC, Liu ZF
Virology 2024 Dec;600:110214
Virology 2024 Dec;600:110214
S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway.
Zhou J, Murata H, Tomonobu N, Mizuta N, Yamakawa A, Yamamoto KI, Kinoshita R, Sakaguchi M
In vitro cellular & developmental biology. Animal 2024 Dec;60(10):1138-1149
In vitro cellular & developmental biology. Animal 2024 Dec;60(10):1138-1149
Bag2 protects against doxorubicin-induced cardiotoxicity by maintaining Pink1-mediated mitophagy.
Xiao H, Liang S, Cai Q, Liu J, Jin L, Chen X
Toxicology 2024 Dec;509:153980
Toxicology 2024 Dec;509:153980
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.
Du L, Guo C, Zeng S, Yu K, Liu M, Li Y
Renal failure 2024 Dec;46(2):2377785
Renal failure 2024 Dec;46(2):2377785
BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells.
Li Y, Wang X, Huang M, Wang X, Li C, Li S, Tang Y, Yu S, Wang Y, Song W, Wu W, Liu Y, Chen YG
The EMBO journal 2024 Dec;43(23):6032-6051
The EMBO journal 2024 Dec;43(23):6032-6051
Glutamine sensing licenses cholesterol synthesis.
Garcia BM, Melchinger P, Medeiros T, Hendrix S, Prabhu K, Corrado M, Kingma J, Gorbatenko A, Deshwal S, Veronese M, Scorrano L, Pearce E, Giavalisco P, Zelcer N, Pernas L
The EMBO journal 2024 Dec;43(23):5837-5856
The EMBO journal 2024 Dec;43(23):5837-5856
ZFP36 Facilitates Senecavirus A (SVA) replication by inhibiting the production of type I interferon.
Yin M, Guan L, Zhang M, Li X, Qian P
Virus research 2024 Dec;350:199498
Virus research 2024 Dec;350:199498
The deficiency of ALKBH5 contributes to hepatic lipid deposition by impairing VPS11-dependent autophagic flux.
Li L, Sun Y, Li L, Zheng W, Zha W, Zhao T, Zhu G, Li H
The FEBS journal 2024 Dec;291(23):5256-5275
The FEBS journal 2024 Dec;291(23):5256-5275
Knockdown of nicotinamide N-methyltransferase ameliorates renal fibrosis caused by ischemia-reperfusion injury and remodels sphingosine metabolism.
Xu W, Hou L
Clinical and experimental nephrology 2024 Dec;28(12):1241-1253
Clinical and experimental nephrology 2024 Dec;28(12):1241-1253
Protective effect of lycorine hydrochloride against diabetic nephropathy in high-fat diet and streptozotocin-induced diabetic mice.
Fang KL, Qi XY, Han QT, Chen LZ, Wang XN, Xu ZP, Shang LQ, Shen T
Pharmaceutical science advances 2024 Dec;2:100035
Pharmaceutical science advances 2024 Dec;2:100035
METTL14 is Involved in TNF-α-Induced Inflammation in Colorectal Epithelial Cells via Autophagy Modulation.
Wu W, Yang H, Li X, Zhou Z, Tan W, Quan JH
Applied biochemistry and biotechnology 2024 Dec;196(12):8453-8470
Applied biochemistry and biotechnology 2024 Dec;196(12):8453-8470
TRIM40 interacts with ROCK1 directly and inhibits colorectal cancer cell proliferation through the c-Myc/p21 axis.
Hu F, Zhao L, Wang J, Li X, Xue Z, Ma Y, Zheng M, Chen C, Tong M, Guo X, Li H, Jin H, Xie Q, Zhang X, Huang C, Huang H
Biochimica et biophysica acta. Molecular cell research 2024 Dec;1871(8):119855
Biochimica et biophysica acta. Molecular cell research 2024 Dec;1871(8):119855
Discovery of epigenetic modulators targeting HDACs and EZH2 simultaneously for the treatment of hematological malignancies.
Zhang J, Yang M, Liu Q, Xue X, Tian S, Hu X, Li M, Li J, Chai Q, Liu F, You X, Zhang Y
Bioorganic chemistry 2024 Dec;153:107964
Bioorganic chemistry 2024 Dec;153:107964
The deubiquitinase OTUB1 inhibits gluconeogenesis by stabilizing YWHAB.
Zhao Q, Wang Q, Li B, Han S, Zhang Y, Wang Y, Lu R, Chen Q, Sun Z, Ding M, Liang Z, Gao Y
Cellular signalling 2024 Dec;124:111408
Cellular signalling 2024 Dec;124:111408
Targeting BRIX1 via Engineered Exosomes Induces Nucleolar Stress to Suppress Cancer Progression.
Gan Y, Hao Q, Han T, Tong J, Yan Q, Zhong H, Gao B, Li Y, Xuan Z, Li P, Yao L, Xu Y, Jiang YZ, Shao ZM, Deng J, Chen J, Zhou X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2407370
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2407370
CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer.
Liu S, Deng P, Yu Z, Hong JH, Gao J, Huang Y, Xiao R, Yin J, Zeng X, Sun Y, Wang P, Geng R, Chan JY, Guan P, Yu Q, Teh BT, Jiang Q, Xia X, Xiong Y, Chen J, Huo Y, Tan J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(45):e2403782
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(45):e2403782
Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates.
Hu T, Kong Y, Tan Y, Ma P, Wang J, Sun X, Xiang K, Mao B, Wu Q, Yi SV, Shi L
bioRxiv : the preprint server for biology 2024 Dec 9;
bioRxiv : the preprint server for biology 2024 Dec 9;
Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition.
Xie X, Zhang B, Li D, Gao J, Li J, Liu C, Dan Y, Xu P, Yan L, Huang X, Zhang R, Yao Y, Huang W, Nie J, Wang X, Jiao B, Ren R, Liu P
Cancer cell international 2024 Dec 5;24(1):396
Cancer cell international 2024 Dec 5;24(1):396
SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia.
Zhao A, Maple L, Jiang J, Myers KN, Jones CG, Gagg H, McGarrity-Cottrell C, Rominiyi O, Collis SJ, Wells G, Rahman M, Danson SJ, Robinson D, Smythe C, Guo C
Cell death & disease 2024 Dec 5;15(12):881
Cell death & disease 2024 Dec 5;15(12):881
Inhibition of protein kinase D and its substrate phosphatidylinositol-4 kinase III beta blocks common human coronavirus replication.
Han H, Liu H, Steiner R, Zhao Z, Jin Z-G
Microbiology spectrum 2024 Dec 5;12(12):e0150124
Microbiology spectrum 2024 Dec 5;12(12):e0150124
S-adenosylmethionine and S-adenosyl-L-homocysteine metabolism is involved in the sperm motility and in vitro fertility rate in mouse.
Kawai T, Fujimura A
Biochemical and biophysical research communications 2024 Dec 31;741:151006
Biochemical and biophysical research communications 2024 Dec 31;741:151006
Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study.
Wang X, Tian W, Wang N, Yang X, Liu Z, Li L, Zhao T, Wang C, Zhang H, Yang H, Jia Y
BMC cancer 2024 Dec 30;24(1):1593
BMC cancer 2024 Dec 30;24(1):1593
Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA.
Lin HH, Yu IS, Cheng MS, Chang TJ, Lin HY, Chang YC, Ko CJ, Chen PH, Lin SW, Huang TC, Huang SY, Chen TY, Kan KW, Huang HP, Lee MS
Nature communications 2024 Dec 3;15(1):10537
Nature communications 2024 Dec 3;15(1):10537
Macrophage NLRP3-dependent IL-1β production contributes to aortic fibrosis in heart failure with preserved ejection fraction.
Chen S, Lu Z
Acta biochimica et biophysica Sinica 2024 Dec 26;57(7):1175-1183
Acta biochimica et biophysica Sinica 2024 Dec 26;57(7):1175-1183
Ancestry-linked stromal variations impact breast epithelial cell invasion.
Schmidtmann M, Elliott V, Clancy J, Nakshatri H, D'Souza-Schorey C
bioRxiv : the preprint server for biology 2024 Dec 26;
bioRxiv : the preprint server for biology 2024 Dec 26;
MS4A3 regulates hematopoietic myeloid differentiation through ROS/TGF-β/p38MAPK pathway.
Dong Y, Yue T, Wang X, Huo Q, Li W, Zhang S, Zhao Y, Li D
International immunopharmacology 2024 Dec 25;143(Pt 3):113578
International immunopharmacology 2024 Dec 25;143(Pt 3):113578
Restoration of RECK expression attenuates liver fibrosis induced by carbon tetrachloride through the Nrf2-MMP9 axis.
Wei B, Huang J, Zhang Y, Hu X, Ma C, Li Y, Chen P
International immunopharmacology 2024 Dec 25;143(Pt 2):113475
International immunopharmacology 2024 Dec 25;143(Pt 2):113475
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis.
Zhao Z, Hu L, Song B, Jiang T, Wu Q, Lin J, Li X, Cai Y, Li J, Qian B, Liu S, Lang J, Yang Z
eLife 2024 Dec 24;13
eLife 2024 Dec 24;13
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Lin S, Li T, Zhang B, Wang P
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Biochemical and biophysical research communications 2024 Dec 20;739:150587
C5aR1-positive adipocytes mediate non-shivering thermogenesis in neonatal mice.
Wang HY, Peng XM, Yang M, Weng Y, Yang X, Zhan D, Ning Q, Luo XP, Chen Y
iScience 2024 Dec 20;27(12):111261
iScience 2024 Dec 20;27(12):111261
SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.
Liu Y, Xu Y, Hao Q, Shi L, Chen Y, Liu Y, Li M, Zhang Y, Li T, Li Y, Jiang Z, Liu Y, Wang C, Bian Z, Yang L, Wang S
Cell death & disease 2024 Dec 20;15(12):921
Cell death & disease 2024 Dec 20;15(12):921
Migratory autolysosome disposal mitigates lysosome damage.
Sho T, Li Y, Jiao H, Yu L
The Journal of cell biology 2024 Dec 2;223(12)
The Journal of cell biology 2024 Dec 2;223(12)
ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis.
Mo Y, Han Y, Chen Y, Fu C, Li Q, Liu Z, Xiao M, Xu B
Molecular cancer 2024 Dec 19;23(1):274
Molecular cancer 2024 Dec 19;23(1):274
Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma.
Shi W, Li L, Zhao H, Li Z, Ma Z, Gu Q, Ye H, Jiang X, Dong Y, Qin L, Zhou H, Yu Z, Jiao Z
Cancer research 2024 Dec 16;84(24):4156-4172
Cancer research 2024 Dec 16;84(24):4156-4172
Eltrombopag restores proliferative capacity and adipose-osteogenic balance of mesenchymal stromal cells in low-risk myelodysplastic syndromes.
Hong M, Guo J, Zhao Y, Song L, Zhao S, Wang R, Shi L, Zhang Z, Wu D, He Q, Chang C
European journal of pharmacology 2024 Dec 15;985:177086
European journal of pharmacology 2024 Dec 15;985:177086
Discovery of sp(3)-rich diazatricycloundecanes as lysosomotropic autophagy inhibitors.
Miura K, Doi T, Umedera K, Nakamura H
European journal of medicinal chemistry 2024 Dec 15;280:116923
European journal of medicinal chemistry 2024 Dec 15;280:116923
Phospho-regulation of ASCL1-mediated chromatin opening during cellular reprogramming.
Azzarelli R, Gillen S, Connor F, Lundie-Brown J, Puletti F, Drummond R, Raffaelli A, Philpott A
Development (Cambridge, England) 2024 Dec 15;151(24)
Development (Cambridge, England) 2024 Dec 15;151(24)
Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system.
Liu J, Zuo Z, Fattah R, Finkel T, Leppla SH, Liu S
mBio 2024 Dec 11;15(12):e0216024
mBio 2024 Dec 11;15(12):e0216024
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis.
Yu Z, Li P, Gao D, Hu Y, Xia F, Liu L, Liu J, Liu W, Zhang H
Immunologic research 2024 Aug;72(4):797-810
Immunologic research 2024 Aug;72(4):797-810
GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma.
Shen NX, Luo MY, Gu WM, Gong M, Lei HM, Bi L, Wang C, Zhang MC, Zhuang G, Xu L, Zhu L, Chen HZ, Shen Y
Oncogene 2024 Aug;43(33):2504-2516
Oncogene 2024 Aug;43(33):2504-2516
GPR124 promotes trophoblast proliferation, migration, and invasion and inhibits trophoblast cell apoptosis and inflammation via JNK and P38 MAPK pathways.
Shen Y, Lian Y, Xiao L, Miu Y, Niu J, Cui Q
Journal of cellular physiology 2024 Aug;239(8):e31298
Journal of cellular physiology 2024 Aug;239(8):e31298
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
Liang L, Zeng J, Liu R, Zheng Z, Lyu D, Zhang X, Wen M, Li M, Xiao H, Sun X, Li M, Huang H
Biochemical pharmacology 2024 Aug;226:116373
Biochemical pharmacology 2024 Aug;226:116373
Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma.
Niu W, Yu H, Fan X, Li S, Sun S, Gong M, Zhang S, Bi W, Chen X, Fang Z
Cellular signalling 2024 Aug;120:111231
Cellular signalling 2024 Aug;120:111231
Assembly mechanism of Integrator's RNA cleavage module.
Sabath K, Qiu C, Jonas S
Molecular cell 2024 Aug 8;84(15):2882-2899.e10
Molecular cell 2024 Aug 8;84(15):2882-2899.e10
Development of Preladenant-Based Radiotracers for Imaging A(2A)R in Tumors.
Zeng X, Liu H, Huang G, Wang Y, Zhou W, Wang Y, Chen X, Cheng X, Zhuang R, Li J, Fang J, Huang L, Zhang X, Guo Z
Journal of medicinal chemistry 2024 Aug 8;67(15):13056-13066
Journal of medicinal chemistry 2024 Aug 8;67(15):13056-13066
EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells.
Croushore EE, Stipp CS, Gordon DJ
International journal of molecular sciences 2024 Aug 6;25(16)
International journal of molecular sciences 2024 Aug 6;25(16)
RILP Induces Cholesterol Accumulation in Lysosomes by Inhibiting Endoplasmic Reticulum-Endolysosome Interactions.
Han Y, Liu X, Xu L, Wei Z, Gu Y, Ren Y, Hua W, Zhang Y, Liu X, Jiang C, Zhuang R, Hong W, Wang T
Cells 2024 Aug 6;13(16)
Cells 2024 Aug 6;13(16)
40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice.
Sun X, Dias L, Peng C, Zhang Z, Ge H, Wang Z, Jin J, Jia M, Xu T, Guo W, Zheng W, He Y, Wu Y, Cai X, Agostinho P, Qu J, Cunha RA, Zhou X, Bai R, Chen JF
Cell discovery 2024 Aug 6;10(1):81
Cell discovery 2024 Aug 6;10(1):81
DAPK1 mediates cognitive dysfunction and neuronal apoptosis in PSD rats through the ERK/CREB/BDNF signaling pathway.
Zhang X, Fan L, Yang L, Jin X, Liu H, Lei H, Song X, Zhang Z, Zhang F, Song J
Behavioural brain research 2024 Aug 5;471:115064
Behavioural brain research 2024 Aug 5;471:115064
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation.
Sun SJ, Jiao XD, Chen ZG, Cao Q, Zhu JH, Shen QR, Liu Y, Zhang Z, Xu FF, Shi Y, Tong J, Ouyang SX, Fu JT, Zhao Y, Ren J, Li DJ, Shen FM, Wang P
Nature communications 2024 Aug 5;15(1):6640
Nature communications 2024 Aug 5;15(1):6640
CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator.
Zhang L, Zhou X, Aryal S, Veasey V, Zhang P, Li FJ, Luan Y, Bhatia R, Zhou Y, Lu R
Cell death & disease 2024 Aug 27;15(8):627
Cell death & disease 2024 Aug 27;15(8):627
Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte.
Wei X, Zhou Y, Shao E, Shi X, Han Y, Zhang Y, Wei G, Zheng H, Huang S, Chen Y, Sun J, Liao Y, Liao W, Wang Y, Bin J, Li X
Cell death discovery 2024 Aug 26;10(1):381
Cell death discovery 2024 Aug 26;10(1):381
Healthy Plasma Exosomes Exert Potential Neuroprotective Effects against Methylmalonic Acid-Induced Hippocampal Neuron Injury.
Zhou W, Li H, Song J, Suo F, Gu M, Qi S
ACS chemical neuroscience 2024 Aug 21;15(16):3022-3033
ACS chemical neuroscience 2024 Aug 21;15(16):3022-3033
FXN targeting induces cell death in ovarian cancer stem-like cells through PRDX3-Mediated oxidative stress.
Xu S, Liu Y, Yang S, Fei W, Qin J, Lu W, Xu J
iScience 2024 Aug 16;27(8):110506
iScience 2024 Aug 16;27(8):110506
Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality.
He Q, Zhao MM, Li MJ, Li XY, Jin JM, Feng YM, Zhang L, Huang WJ, Yang F, Yang JK
eLife 2024 Aug 16;13
eLife 2024 Aug 16;13
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation.
Zhang T, Pan Z, Gao J, Wu Q, Bai G, Li Y, Tong L, Feng F, Lai M, Liu Y, Song P, Ning Y, Tang H, Luo W, Chen Y, Fang Y, Zhang H, Liu Q, Zhang Y, Wang H, Chen Z, Chen Y, Geng M, Ji H, Zhao G, Zhou H, Ding J, Xie H
Signal transduction and targeted therapy 2024 Aug 15;9(1):216
Signal transduction and targeted therapy 2024 Aug 15;9(1):216
FYN-mediated phosphorylation of BCKDK at Y151 promotes GBM proliferation by increasing the oncogenic metabolite N-acetyl-L-alanine.
Zou L, Wang W, Huang W, Ni X, Li W, Cheng Y, Tian Q, Liu L, Zhu F, Duan Q
Heliyon 2024 Aug 15;10(15):e33663
Heliyon 2024 Aug 15;10(15):e33663
Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation.
Bao L, Zhu J, Shi T, Jiang Y, Li B, Huang J, Ji X
Nucleic acids research 2024 Aug 12;52(14):8165-8183
Nucleic acids research 2024 Aug 12;52(14):8165-8183
Capsaicin enhances cisplatin-induced anti-metastasis of nasopharyngeal carcinoma by inhibiting EMT and ERK signaling via serpin family B member 2.
Xu Y, Kong W, Zhao S, Xiong D, Wang Y
Carcinogenesis 2024 Aug 12;45(8):556-568
Carcinogenesis 2024 Aug 12;45(8):556-568
Membranous translocation of murine double minute 2 promotes the increased renal tubular immunogenicity in ischemia-reperfusion-induced acute kidney injury.
Zeng J, Ye C, Zhang C, Su H
American journal of physiology. Renal physiology 2024 Aug 1;327(2):F290-F303
American journal of physiology. Renal physiology 2024 Aug 1;327(2):F290-F303
Single-Cell RNA Sequencing Identifies WARS1+ Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Improved Therapeutic Efficacy.
Li X, Zhang F, Sun L, Cai X, Lou F, Sun Y, Gao M, Wang Z, Tang S, Fan L, Wu Y, Jin X, Deng S, Xu Z, Sun X, Li Q, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2024 Aug 1;213(3):257-267
Journal of immunology (Baltimore, Md. : 1950) 2024 Aug 1;213(3):257-267
Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer.
Ho CC, Gilbert MB, Urtecho G, Lee H, Drew DA, Klempner SJ, Cho JS, Ryan TJ, Rustgi N, Lee H, Lee J, Caraballo A, Magicheva-Gupta MV, Rios C, Shin AE, Tseng YY, Davis JL, Chung DC, Chan AT, Wang HH, Ryeom S
Cancer prevention research (Philadelphia, Pa.) 2024 Aug 1;17(8):361-376
Cancer prevention research (Philadelphia, Pa.) 2024 Aug 1;17(8):361-376
Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation.
Wen X, Zhang J, Xu Z, Li M, Dong X, Du Y, Xu Z, Yan L
Reproduction (Cambridge, England) 2024 Aug 1;168(2)
Reproduction (Cambridge, England) 2024 Aug 1;168(2)
Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency.
Yao Y, Jin C, Liao Y, Huang X, Wei Z, Zhang Y, Li D, Su H, Han W, Qin D
Aging and disease 2024 Aug 1;15(4):1952-1968
Aging and disease 2024 Aug 1;15(4):1952-1968
Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex.
Zhang Z, Li Y, Yang J, Li J, Lin X, Liu T, Yang S, Lin J, Xue S, Yu J, Tang C, Li Z, Liu L, Ye Z, Deng Y, Li Z, Chen K, Ding H, Luo C, Lin H
Nature communications 2024 Aug 1;15(1):6477
Nature communications 2024 Aug 1;15(1):6477
Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
Desai M, Hemant, Deo A, Naik J, Dhamale P, Kshirsagar A, Bose T, Majumdar A
PLoS biology 2024 Apr;22(4):e3002585
PLoS biology 2024 Apr;22(4):e3002585
Spinal sirtuin 2 attenuates bone cancer pain by deacetylating FoxO3a.
Yang C, Kang F, Huang X, Wu W, Hou G, Zheng K, Han M, Kan B, Zhang Z, Li J
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167129
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167129
Pyrazole derivative Z10 ameliorates acute pancreatitis by inhibiting the ERK/Ddt pathway.
Zeng W, Pan J, Li W, Huang B, Lu X, Xiao J
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167088
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167088
Trilobatin attenuates cerebral ischaemia/reperfusion-induced blood-brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive.
Feng L, Li Y, Lin M, Xie D, Luo Y, Zhang Y, He Z, Gong Q, Zhun ZY, Gao J
British journal of pharmacology 2024 Apr;181(7):1005-1027
British journal of pharmacology 2024 Apr;181(7):1005-1027
The role of Map1b in regulating osteoblast polarity, proliferation, differentiation and migration.
Peng L, Zhang D, Tu H, Wu D, Xiang S, Yang W, Zhao Y, Yang J
Bone 2024 Apr;181:117038
Bone 2024 Apr;181:117038
Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain.
Li Y, Yin C, Jiang J, Yang H, Zhang F, Xing Y, Wang W, Lu C
The international journal of biochemistry & cell biology 2024 Apr;169:106541
The international journal of biochemistry & cell biology 2024 Apr;169:106541
Amplified and Specific Staining of Protein Dimerization on Cell Membrane Catalyzed by Responsively Installed DNA Nanomachines for Cancer Diagnosis.
Wang Z, Xie X, Jin K, Xia D, Zhu J, Zhang J
Advanced healthcare materials 2024 Apr;13(10):e2303398
Advanced healthcare materials 2024 Apr;13(10):e2303398
Shen-Shuai-II-Recipe inhibits tubular inflammation by PPARα-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys.
Wang M, Wang L, Zhou L, Xu Y, Wang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155450
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155450
Identification of CERS5 as a molecular biomarker in pan-cancer through multiple omics integrative analysis.
Wang S, Yang J, Huang W, Yu Z, Mao Y, Feng Y, Chen J
Cellular signalling 2024 Apr;116:111054
Cellular signalling 2024 Apr;116:111054
Nanoparticle Targeting in Chemo-Resistant Ovarian Cancer Reveals Dual Axis of Therapeutic Vulnerability Involving Cholesterol Uptake and Cell Redox Balance.
Wang Y, Calvert AE, Cardenas H, Rink JS, Nahotko D, Qiang W, Ndukwe CE, Chen F, Keathley R, Zhang Y, Cheng JX, Thaxton CS, Matei D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(13):e2305212
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(13):e2305212
Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma.
Li Z, Lu W, Yin F, Zeng P, Li H, Huang A
Journal of translational medicine 2024 Apr 9;22(1):340
Journal of translational medicine 2024 Apr 9;22(1):340
Genetic interactions reveal distinct biological and therapeutic implications in breast cancer.
Lin CJ, Jin X, Ma D, Chen C, Ou-Yang Y, Pei YC, Zhou CZ, Qu FL, Wang YJ, Liu CL, Fan L, Hu X, Shao ZM, Jiang YZ
Cancer cell 2024 Apr 8;42(4):701-719.e12
Cancer cell 2024 Apr 8;42(4):701-719.e12
BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling.
Huang X, Guo J, Ning A, Zhang N, Sun Y
Cardiovascular diabetology 2024 Apr 25;23(1):140
Cardiovascular diabetology 2024 Apr 25;23(1):140
m(1)A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma.
Wu Y, Li L, Wang L, Zhang S, Zeng Z, Lu J, Wang Z, Zhang Y, Zhang S, Li H, Chen T
BMC cancer 2024 Apr 22;24(1):506
BMC cancer 2024 Apr 22;24(1):506
Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy.
Renaud CCN, Nicolau CA, Maghe C, Trillet K, Jardine J, Escot S, David N, Gavard J, Bidère N
iScience 2024 Apr 19;27(4):109580
iScience 2024 Apr 19;27(4):109580
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores.
Wei B, Fu Y, Li X, Chen F, Zhang Y, Chen H, Tong M, Li L, Pan Y, Zhang S, Chen S, Liu X, Zhong Q
Cell discovery 2024 Apr 16;10(1):43
Cell discovery 2024 Apr 16;10(1):43
KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity.
Qiang Y, Fan J, Xie C, Yan L, Song X, Zhang N, Lin Y, Xiong J, Zhang W, Liu Y, Wei L, Li Y, Chen S, Liang K, Li F
Cancer research 2024 Apr 15;84(8):1252-1269
Cancer research 2024 Apr 15;84(8):1252-1269
PRMT4 interacts with NCOA4 to inhibit ferritinophagy in cisplatin-induced acute kidney injury.
Zhou L, Deng Z, Wang Y, Zhang H, Yan S, Kanwar YS, Wang Y, Dai Y, Deng F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23584
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23584
GTPBP8 modulates mitochondrial fission through a Drp1-dependent process.
He X, Wang L, Tsang HY, Liu X, Yang X, Pu S, Guo Z, Yang C, Wu Q, Zhou Z, Cen X, Zhao H
Journal of cell science 2024 Apr 15;137(8)
Journal of cell science 2024 Apr 15;137(8)
Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy.
Chen L, Xing X, Zhu Y, Chen Y, Pei H, Song Q, Li J, Zhang P
Cancer letters 2024 Apr 10;587:216696
Cancer letters 2024 Apr 10;587:216696
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.
Mann MJ, Melendez-Suchi C, Vorndran HE, Sukhoplyasova M, Flory AR, Irvine MC, Iyer AR, Guerriero CJ, Brodsky JL, Hendershot LM, Buck TM
Molecular biology of the cell 2024 Apr 1;35(4):ar59
Molecular biology of the cell 2024 Apr 1;35(4):ar59
Tepsin binds LC3B to promote ATG9A trafficking and delivery.
Wallace NS, Gadbery JE, Cohen CI, Kendall AK, Jackson LP
Molecular biology of the cell 2024 Apr 1;35(4):ar56
Molecular biology of the cell 2024 Apr 1;35(4):ar56
PCP4 Promotes Alzheimer's Disease Pathogenesis by Affecting Amyloid-β Protein Precursor Processing.
Hu D, Dong X, Wang Q, Liu M, Luo S, Meng Z, Feng Z, Zhou W, Song W
Journal of Alzheimer's disease : JAD 2023;94(2):737-750
Journal of Alzheimer's disease : JAD 2023;94(2):737-750
Platelet-Derived Mitochondria Attenuate 5-FU-Induced Injury to Bone-Associated Mesenchymal Stem Cells.
Chen Y, Liu Z, An N, Zhang J, Meng W, Wang W, Wu X, Hu X, Chen Y, Yin W
Stem cells international 2023;2023:7482546
Stem cells international 2023;2023:7482546
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Pan W, Xiang L, Liang X, Du W, Zhao J, Zhang S, Zhou X, Geng L, Gong S, Xu W
Mediators of inflammation 2023;2023:6623329
Mediators of inflammation 2023;2023:6623329
Comprehensive Analysis of Sideroflexin 4 in Hepatocellular Carcinoma by Bioinformatics and Experiments.
Du Z, Zhang Z, Han X, Xie H, Yan W, Tian D, Liu M, Rao C
International journal of medical sciences 2023;20(10):1300-1315
International journal of medical sciences 2023;20(10):1300-1315
Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation.
Huang D, Zhao D, Li M, Chang SY, Xue YD, Xu N, Li SJ, Tang NN, Gong LL, Liu YN, Yu H, Li QS, Li PY, Liu JL, Chen HX, Liu MB, Zhang WY, Zhao XM, Lang XZ, Li ZD, Liu Y, Ma ZY, Li JM, Wang N, Tian H, Cai BZ
International journal of biological sciences 2023;19(3):994-1006
International journal of biological sciences 2023;19(3):994-1006
Low expression of m6A reader YTHDC1 promotes progression of ovarian cancer via PIK3R1/STAT3/GANAB axis.
Wang X, Chen Q, Bing Z, Zhou S, Xu Z, Hou Y, Zhao Y, Zhao S, Wang T
International journal of biological sciences 2023;19(14):4672-4688
International journal of biological sciences 2023;19(14):4672-4688
Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice.
Hu M, Bodnar B, Zhang Y, Xie F, Li F, Li S, Zhao J, Zhao R, Gedupoori N, Mo Y, Lin L, Li X, Meng W, Yang X, Wang H, Barbe MF, Srinivasan S, Bethea JR, Mo X, Xu H, Hu W
International journal of biological sciences 2023;19(10):3226-3248
International journal of biological sciences 2023;19(10):3226-3248
Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor.
Anchoori RK, Anchoori V, Lam B, Tseng SH, Das S, Velasquez FC, Karanam B, Poddatoori D, Patnam R, Rudek MA, Chang YN, Roden RBS
PloS one 2023;18(6):e0285221
PloS one 2023;18(6):e0285221
Transplantation of Human Amniotic Mesenchymal Stem Cells Up-Regulates Angiogenic Factor Expression to Attenuate Diabetic Kidney Disease in Rats.
Ni Y, Chen Y, Jiang X, Pu T, Zhang L, Li S, Hu L, Bai B, Hu T, Yu L, Yang Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:331-343
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:331-343
Expression and Clinical Significance of TIGIT in Primary Breast Cancer.
Tang L, Sha M, Guo T, Lu H, Qian J, Shao Q, Ye J
International journal of general medicine 2023;16:2405-2417
International journal of general medicine 2023;16:2405-2417
Gongying-Jiedu-Xiji recipe promotes the healing of venous ulcers by inhibiting ferroptosis via the CoQ-FSP1 axis.
Lu Y, Zhao D, Liu M, Cao G, Liu C, Yin S, Song R, Ma J, Sun R, Wu Z, Liu J, Wang Y
Frontiers in pharmacology 2023;14:1291099
Frontiers in pharmacology 2023;14:1291099
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.
Luo W, Xu G, Song Z, Mu W, Wen J, Hui S, Zhao J, Zhan X, Bai Z, Xiao X
Frontiers in pharmacology 2023;14:1160445
Frontiers in pharmacology 2023;14:1160445
GNPNAT1 is a potential biomarker correlated with immune infiltration and immunotherapy outcome in breast cancer.
Yuan R, Zhang Y, Wang Y, Chen H, Zhang R, Hu Z, Chai C, Chen T
Frontiers in immunology 2023;14:1152678
Frontiers in immunology 2023;14:1152678
ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes.
Suzuki Y, Kami D, Taya T, Sano A, Ogata T, Matoba S, Gojo S
Frontiers in immunology 2023;14:1089905
Frontiers in immunology 2023;14:1089905
Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Li Y, Chai JL, Shi X, Feng Y, Li JJ, Zhou LN, Cao C, Li KR
Theranostics 2023;13(7):2319-2336
Theranostics 2023;13(7):2319-2336
Inhibition of Na+/H+ exchanger (NHE) 7 by 5-(N-ethyl-N-isopropyl)-Amiloride displays anti-cancer activity in non-small cell lung cancer by disrupting cancer stem cell activity and downregulating PD-L1 expression.
Wang BY, Shen HT, Lee YL, Chien PJ, Chang WW
American journal of cancer research 2023;13(10):4721-4733
American journal of cancer research 2023;13(10):4721-4733
EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO.
Barbeito P, Martin-Morales R, Palencia-Campos A, Cerrolaza J, Rivas-Santos C, Gallego-Colastra L, Caparros-Martin JA, Martin-Bravo C, Martin-Hurtado A, Sánchez-Bellver L, Marfany G, Ruiz-Perez VL, Garcia-Gonzalo FR
Frontiers in cell and developmental biology 2023;11:1190258
Frontiers in cell and developmental biology 2023;11:1190258
Hypoxanthine guanine phosphoribosyltransferase 1, a target of miR-125b-5p, promotes cell proliferation and invasion in head and neck squamous cell carcinoma.
Yuan L, Xiao Z, Lu R
Heliyon 2023 Sep;9(9):e20174
Heliyon 2023 Sep;9(9):e20174
Functional Characterization of MC4R Variants in Chinese Morbid Obese Patients and Weight Loss after Bariatric Surgery.
Gong Y, Wu Q, Huang S, Fu Z, Ye J, Liu R, Lin S, Guan W, Yang N, Li JZ, Liang H, Zhou H
Advanced biology 2023 Sep;7(9):e2300007
Advanced biology 2023 Sep;7(9):e2300007
Dietary Eicosapentaenoic Acid Containing Phosphoethanolamine Plasmalogens Remodels the Lipidome of White Adipose Tissue and Suppresses High-Fat Diet Induced Obesity in Mice.
Ding L, Yang J, Guo H, Cong P, Xu J, Xue C, Mao X, Zhang T, Wang Y
Molecular nutrition & food research 2023 Sep;67(18):e2200321
Molecular nutrition & food research 2023 Sep;67(18):e2200321
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
Miao Y, Qian G, Zhang R, Yuan Y, Zuo Y, Ding Y, Li X, Tang Y, Zheng H, Lv H
The FEBS journal 2023 Sep;290(17):4224-4237
The FEBS journal 2023 Sep;290(17):4224-4237
Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells.
Meng S, Liu X, Zhu S, Xie P, Fang H, Pan Q, Fang K, Li F, Zhang J, Che Z, Zhang Q, Mao G, Wang Y, Hu P, Chen K, Sun F, Xie W, Luo Z, Lin C
Nature cell biology 2023 Sep;25(9):1319-1331
Nature cell biology 2023 Sep;25(9):1319-1331
RBMX involves in telomere stability maintenance by regulating TERRA expression.
Liu J, Zheng T, Chen D, Huang J, Zhao Y, Ma W, Liu H
PLoS genetics 2023 Sep;19(9):e1010937
PLoS genetics 2023 Sep;19(9):e1010937
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
Guo Y, Shao J, Zhang R, Han M, Kong L, Liu Z, Li H, Wei D, Lu M, Zhang S, Zhang C, Wei H, Chen Z, Bian H
International journal of molecular sciences 2023 Sep 7;24(18)
International journal of molecular sciences 2023 Sep 7;24(18)
Centrosome linker diversity and its function in centrosome clustering and mitotic spindle formation.
Theile L, Li X, Dang H, Mersch D, Anders S, Schiebel E
The EMBO journal 2023 Sep 4;42(17):e109738
The EMBO journal 2023 Sep 4;42(17):e109738
Increased DNMT1 Involvement in the Activation of LO2 Cell Death Induced by Silver Nanoparticles via Promoting TFEB-Dependent Autophagy.
Chen J, Zheng D, Cai Z, Zhong B, Zhang H, Pan Z, Ling X, Han Y, Meng J, Li H, Chen X, Zhang H, Liu L
Toxics 2023 Sep 4;11(9)
Toxics 2023 Sep 4;11(9)
Baicalin Attenuates Panton-Valentine Leukocidin (PVL)-Induced Cytoskeleton Rearrangement via Regulating the RhoA/ROCK/LIMK and PI3K/AKT/GSK-3β Pathways in Bovine Mammary Epithelial Cells.
Yang J, Hai Z, Hou L, Liu Y, Zhang D, Zhou X
International journal of molecular sciences 2023 Sep 25;24(19)
International journal of molecular sciences 2023 Sep 25;24(19)
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Zeng J, Liang L, Chen R, Li C, Pan L, Wen M, Lv D, Liu M, Xu Z, Huang H
European journal of pharmacology 2023 Sep 15;955:175915
European journal of pharmacology 2023 Sep 15;955:175915
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Zhang Y, Zhou J, Zeng L, Xiong Y, Wang X, Xiang W, Su P
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.
Cicardi ME, Hallgren JH, Mawrie D, Krishnamurthy K, Markandaiah SS, Nelson AT, Kankate V, Anderson EN, Pasinelli P, Pandey UB, Eischen CM, Trotti D
iScience 2023 Sep 15;26(9):107505
iScience 2023 Sep 15;26(9):107505
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics.
Mouti MA, Deng S, Pook M, Malzahn J, Rendek A, Militi S, Nibhani R, Soonawalla Z, Oppermann U, Hwang CI, Pauklin S
Nature communications 2023 Sep 14;14(1):5685
Nature communications 2023 Sep 14;14(1):5685
Perillaldehyde Mitigates Ionizing Radiation-Induced Intestinal Injury by Inhibiting Ferroptosis via the Nrf2 Signaling Pathway.
Tang LF, Ma X, Xie LW, Zhou H, Yu J, Wang ZX, Li M
Molecular nutrition & food research 2023 Oct;67(19):e2300232
Molecular nutrition & food research 2023 Oct;67(19):e2300232
Effect of eIF2α in Neuronal Injury Induced by High Glucose and the Protective Mechanism of Resveratrol.
Zhang L, Zhi K, Su Y, Peng W, Meng X
Molecular neurobiology 2023 Oct;60(10):6043-6059
Molecular neurobiology 2023 Oct;60(10):6043-6059
Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1.
Asami E, Kitami M, Ida T, Kobayashi T, Saeki M
Immunopharmacology and immunotoxicology 2023 Oct;45(5):589-596
Immunopharmacology and immunotoxicology 2023 Oct;45(5):589-596
Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer.
Miller KD, O'Connor S, Pniewski KA, Kannan T, Acosta R, Mirji G, Papp S, Hulse M, Mukha D, Hlavaty SI, Salcido KN, Bertolazzi F, Srikanth YVV, Zhao S, Wellen KE, Shinde RS, Claiborne DT, Kossenkov A, Salvino JM, Schug ZT
Nature cancer 2023 Oct;4(10):1491-1507
Nature cancer 2023 Oct;4(10):1491-1507
RNA-binding protein-regulated fibronectin is essential for EGFR-activated metastasis of head and neck squamous cell carcinoma.
Shieh JM, Chang TW, Wang JH, Liang SP, Kao PL, Chen LY, Yen CJ, Chen YJ, Chang WC, Chen BK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23206
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23206
Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.
Li M, Wei J, Zhu G, Fu S, He X, Hu X, Yu Y, Mou Y, Wang J, You X, Xiao X, Gu T, Ye Z, Zha Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178
Niclosamide inhibits TGF-β1-induced fibrosis of human Tenon's fibroblasts by regulating the MAPK-ERK1/2 pathway.
Zhang L, Li W, Liu X, Guo J, Wu X, Wang J
Experimental eye research 2023 Oct;235:109628
Experimental eye research 2023 Oct;235:109628
Unveiling potentially convergent key events related to adverse outcome pathways induced by silver nanoparticles via cross-species omics-scale analysis.
Anh NH, Min YJ, Thi My Nhung T, Long NP, Han S, Kim SJ, Jung CW, Yoon YC, Kang YP, Park SK, Kwon SW
Journal of hazardous materials 2023 Oct 5;459:132208
Journal of hazardous materials 2023 Oct 5;459:132208
Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease.
Zang L, Yang X, Chen Y, Huang F, Yuan Y, Chen X, Zuo Y, Miao Y, Gu J, Guo H, Xia W, Peng Y, Tang M, Huang Z, Wang Y, Ma J, Jiang J, Zhou W, Zheng H, Shi W
Journal of virology 2023 Oct 31;97(10):e0078623
Journal of virology 2023 Oct 31;97(10):e0078623
DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation.
Zhang Q, Feng P, Zhu XH, Zhou SQ, Ye ML, Yang XJ, Gong S, Huang SY, Tan XR, He SW, Li YQ
Cell death & disease 2023 Oct 24;14(10):697
Cell death & disease 2023 Oct 24;14(10):697
Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes.
Zhao Q, Yu C, Xu X, Jin W, Zhang Z, Huang H, Gao Y, Pan D
iScience 2023 Oct 20;26(10):108091
iScience 2023 Oct 20;26(10):108091
15-keto-PGE(2) alleviates nonalcoholic steatohepatitis through its covalent modification of NF-κB factors.
Hee SW, Chang YC, Su L, Chen IJ, Jeng YM, Hsieh ML, Chang YC, Li FA, Liao D, Chen SM, Chuang LM
iScience 2023 Oct 20;26(10):107997
iScience 2023 Oct 20;26(10):107997
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions.
Mann MJ, Melendez-Suchi C, Sukhoplyasova M, Flory AR, Carson Irvine M, Iyer AR, Vorndran H, Guerriero CJ, Brodsky JL, Hendershot LM, Buck TM
bioRxiv : the preprint server for biology 2023 Oct 20;
bioRxiv : the preprint server for biology 2023 Oct 20;
Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation.
Wang X, Wang Y, Cao A, Luo Q, Chen D, Zhao W, Xu J, Li Q, Bu X, Quan J
Nature communications 2023 Oct 2;14(1):6132
Nature communications 2023 Oct 2;14(1):6132
Phase separation underlies signaling activation of oncogenic NTRK fusions.
Zhu T, Xie J, He H, Li H, Tang X, Wang S, Li Z, Tian Y, Li L, Zhu J, Zhu G
Proceedings of the National Academy of Sciences of the United States of America 2023 Oct 17;120(42):e2219589120
Proceedings of the National Academy of Sciences of the United States of America 2023 Oct 17;120(42):e2219589120
RAP80 phase separation at DNA double-strand break promotes BRCA1 recruitment.
Qin C, Wang YL, Zhou JY, Shi J, Zhao WW, Zhu YX, Bai SM, Feng LL, Bie SY, Zeng B, Zheng J, Zeng GD, Feng WX, Wan XB, Fan XJ
Nucleic acids research 2023 Oct 13;51(18):9733-9747
Nucleic acids research 2023 Oct 13;51(18):9733-9747
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer.
Liu W, Chen S, Xie W, Wang Q, Luo Q, Huang M, Gu M, Lan P, Chen D
Cellular & molecular biology letters 2023 Oct 12;28(1):80
Cellular & molecular biology letters 2023 Oct 12;28(1):80
Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
Ecotoxicology and environmental safety 2023 Oct 1;264:115401
USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.
Choi Y, Lee Y, Kim JS, Zhang P, Kim J
Biomolecules 2023 Oct 1;13(10)
Biomolecules 2023 Oct 1;13(10)
Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPARγ signaling.
Schuermans N, El Chehadeh S, Hemelsoet D, Gautheron J, Vantyghem MC, Nouioua S, Tazir M, Vigouroux C, Auclair M, Bogaert E, Dufour S, Okawa F, Hilbert P, Van Doninck N, Taquet MC, Rosseel T, De Clercq G, Debackere E, Van Haverbeke C, Cherif FR, Urtizberea JA, Chanson JB, Funalot B, Authier FJ, Kaya S, Terryn W, Callens S, Depypere B, Van Dorpe J, Program for Undiagnosed Diseases (UD-PrOZA), Poppe B, Impens F, Mizushima N, Depienne C, Jéru I, Dermaut B
Nature genetics 2023 Nov;55(11):1929-1940
Nature genetics 2023 Nov;55(11):1929-1940
D-mannose induces TFE3-dependent lysosomal degradation of EGFR and inhibits the progression of NSCLC.
Sun X, Dai Y, He J, Li H, Yang X, Dong W, Xie X, Wang M, Xu Y, Lv L
Oncogene 2023 Nov;42(47):3503-3513
Oncogene 2023 Nov;42(47):3503-3513
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.
Luo H, Jiao QB, Shen CB, Gong WY, Yuan JH, Liu YY, Chen Z, Liu J, Xu XL, Cong YS, Zhang XW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23221
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23221
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY, Piao HL, Zhou J, Lin SC
Cell research 2023 Nov;33(11):835-850
Cell research 2023 Nov;33(11):835-850
"Affimer" synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation.
Roper BWR, Tiede C, Abdul-Zani I, Cuthbert GA, Jade D, Al-Aufi A, Critchley WR, Saikia Q, Homer-Vanniasinkam S, Sawamura T, McPherson MJ, Harrison MA, Tomlinson DC, Ponnambalam S
The Journal of biological chemistry 2023 Nov;299(11):105325
The Journal of biological chemistry 2023 Nov;299(11):105325
Embryonic stem cell-derived extracellular vesicles rejuvenate senescent cells and antagonize aging in mice.
Yu L, Wen H, Liu C, Wang C, Yu H, Zhang K, Han Q, Liu Y, Han Z, Li Z, Liu N
Bioactive materials 2023 Nov;29:85-97
Bioactive materials 2023 Nov;29:85-97
Hypomethylation of DRD2 promotes breast cancer through the FLNA-ERK pathway.
Zhang S, Zhong M, Zhu H, You Q, Yuan H, Li Y
Cancer genetics 2023 Nov;278-279:71-78
Cancer genetics 2023 Nov;278-279:71-78
The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury.
Yu Z, Cheng X, Pan W, Yu C, Duan Y
Neural regeneration research 2023 Nov;18(11):2482-2488
Neural regeneration research 2023 Nov;18(11):2482-2488
A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3.
Tan X, Ma X, Dai Y, An J, Yu X, Li S, Liao Y, Pei T, Tang Y, Gui Y, Zhou S, Guo D, Deng Y, Hu K, Wang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155031
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155031
PRMT1 promotes the proliferation and metastasis of gastric cancer cells by recruiting MLXIP for the transcriptional activation of the β-catenin pathway.
Wang F, Chen S, Peng S, Zhou X, Tang H, Liang H, Zhong X, Yang H, Ke X, Lü M, Cui H
Genes & diseases 2023 Nov;10(6):2622-2638
Genes & diseases 2023 Nov;10(6):2622-2638
Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance.
Zhu Y, Ye X, Shen H, Li J, Cai Z, Min W, Hou Y, Dong H, Wu Y, Wang L, Wang X, Xiao Y, Yang P
Journal of medicinal chemistry 2023 Nov 9;66(21):14633-14652
Journal of medicinal chemistry 2023 Nov 9;66(21):14633-14652
p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP.
Huang Y, Xiong C, Wang C, Deng J, Zuo Z, Wu H, Xiong J, Wu X, Lu H, Hao Q, Zhou X
Cell reports 2023 Nov 28;42(11):113426
Cell reports 2023 Nov 28;42(11):113426
Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer.
Shi S, Guo D, Ye L, Li T, Fei Q, Lin M, Yu X, Jin K, Wu W
Cell death & disease 2023 Nov 27;14(11):778
Cell death & disease 2023 Nov 27;14(11):778
Time-resolved proteomic profiling reveals compositional and functional transitions across the stress granule life cycle.
Hu S, Zhang Y, Yi Q, Yang C, Liu Y, Bai Y
Nature communications 2023 Nov 27;14(1):7782
Nature communications 2023 Nov 27;14(1):7782
Nuclear-cytoplasmic asynchrony in oocyte maturation caused by TUBB8 variants via impairing microtubule function: a novel pathogenic mechanism.
Chang T, Zhao J, Li Q, Meng A, Xia Q, Li Y, Xiang W, Yao Z
Reproductive biology and endocrinology : RB&E 2023 Nov 22;21(1):109
Reproductive biology and endocrinology : RB&E 2023 Nov 22;21(1):109
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity.
Stewart H, Lu Y, O'Keefe S, Valpadashi A, Cruz-Zaragoza LD, Michel HA, Nguyen SK, Carnell GW, Lukhovitskaya N, Milligan R, Adewusi Y, Jungreis I, Lulla V, Matthews DA, High S, Rehling P, Emmott E, Heeney JL, Davidson AD, Edgar JR, Smith GL, Firth AE
iScience 2023 Nov 17;26(11):108080
iScience 2023 Nov 17;26(11):108080
Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma.
Wang J, Zhang X, Ma X, Chen D, Cai M, Xiao L, Li J, Huang Z, Huang Y, Lian Y
Journal of experimental & clinical cancer research : CR 2023 Nov 16;42(1):303
Journal of experimental & clinical cancer research : CR 2023 Nov 16;42(1):303
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51.
Tao L, Zhou Y, Pan X, Luo Y, Qiu J, Zhou X, Chen Z, Li Y, Xu L, Zhou Y, Zuo Z, Liu C, Wang L, Liu X, Tian X, Su N, Yang Z, Zhang Y, Gou K, Sang N, Liu H, Zou J, Xiao Y, Zhong X, Xu J, Yang X, Xiao K, Liu Y, Yang S, Peng Y, Han J, Cen X, Zhao Y
Nature communications 2023 Nov 16;14(1):7430
Nature communications 2023 Nov 16;14(1):7430
Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis.
Denaroso GE, Smith Z, Angeliu CG, Cheli VT, Wang C, Paez PM
Journal of neuroinflammation 2023 Nov 14;20(1):263
Journal of neuroinflammation 2023 Nov 14;20(1):263
Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis.
Kang H, Feng J, Peng Y, Liu Y, Yang Y, Wu Y, Huang J, Jie Y, Chen B, He Y
Stem cell research & therapy 2023 Nov 14;14(1):328
Stem cell research & therapy 2023 Nov 14;14(1):328
Asparagine endopeptidase protects podocytes in adriamycin-induced nephropathy by regulating actin dynamics through cleaving transgelin.
Qiu Y, Lei C, Zeng J, Xie Y, Cao Y, Yuan Q, Su H, Zhang Z, Zhang C
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Nov 1;31(11):3337-3354
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Nov 1;31(11):3337-3354
Tumor necrosis factor-α-induced protein 8-like 2 alleviates morphine antinociceptive tolerance through reduction of ROS-mediated apoptosis and MAPK/NF-κB signaling pathways.
Yang Z, Zhang F, Abdul M, Jiang J, Li Y, Li Y, Yin C, Xing Y, Liu S, Lu C
Neuropharmacology 2023 Nov 1;238:109667
Neuropharmacology 2023 Nov 1;238:109667
Genome-Wide CRISPR/Cas9 Screening Identifies That Mitochondrial Solute Carrier SLC25A23 Attenuates Type I IFN Antiviral Immunity via Interfering with MAVS Aggregation.
Zhang H, Li X, Wang Y, Liu X, Guo J, Wang Z, Zhang L, Xiong S, Dong C
Journal of immunology (Baltimore, Md. : 1950) 2023 Nov 1;211(9):1406-1417
Journal of immunology (Baltimore, Md. : 1950) 2023 Nov 1;211(9):1406-1417
TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination.
Chen YY, Ran XH, Ni RZ, Mu D
The Journal of biological chemistry 2023 May;299(5):104660
The Journal of biological chemistry 2023 May;299(5):104660
Prognostic role and immune infiltration characteristics of EI24 in multiple cancer types.
Yang W, Zhou W, Zhao X, Duan L, Niu L, Zhang Y, Li Y, Wang X, Chen J, Fan A, Xie Q, Liu J, Han Y, Fan D, Hong L
Expert review of molecular diagnostics 2023 May;23(5):457-469
Expert review of molecular diagnostics 2023 May;23(5):457-469
Prophylaxis of posterior capsule opacification through autophagy activation with indomethacin-eluting intraocular lens.
Zhang X, Wang J, Xu J, Xu W, Zhang Y, Luo C, Ni S, Han H, Shentu X, Ye J, Ji J, Yao K
Bioactive materials 2023 May;23:539-550
Bioactive materials 2023 May;23:539-550
Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion.
Huang LY, Ma JY, Song JX, Xu JJ, Hong R, Fan HD, Cai H, Wang W, Wang YL, Hu ZL, Shen JG, Qi SH
Neural regeneration research 2023 May;18(5):1040-1045
Neural regeneration research 2023 May;18(5):1040-1045
Fecal microbiota transplantation ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota in db/db mice.
Chen L, Guo L, Feng S, Wang C, Cui Z, Wang S, Lu Q, Chang H, Hang B, Snijders AM, Mao JH, Lu Y, Ding D
BMJ open diabetes research & care 2023 May;11(3)
BMJ open diabetes research & care 2023 May;11(3)
Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis.
Wang XL, Li JM, Yuan SQ
Asian journal of andrology 2023 May-Jun;25(3):314-321
Asian journal of andrology 2023 May-Jun;25(3):314-321
Repurposing crizotinib to target RIPK1-dependent cell death.
Yu Y, Li M, Fu S, He X, Hu X, Zhu G, Wang J, You X, Mou Y, Ye Z, Wei J, Zha Y
International immunology 2023 May 8;35(5):221-230
International immunology 2023 May 8;35(5):221-230
Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis.
Zhang X, Cui K, Wang X, Tong Y, Liu C, Zhu Y, You Q, Jiang Z, Guo X
Antioxidants (Basel, Switzerland) 2023 May 8;12(5)
Antioxidants (Basel, Switzerland) 2023 May 8;12(5)
Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus.
Song C, Zhao J, Hao J, Mi D, Zhang J, Liu Y, Wu S, Gao F, Jiang W
Cell death discovery 2023 May 4;9(1):144
Cell death discovery 2023 May 4;9(1):144
Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy.
Chen H, Yin L, Yang J, Ren N, Chen J, Lu Q, Huang Y, Feng Y, Wang W, Wang S, Liu Y, Song Y, Li Y, Jin J, Tan W, Lin D
Cancer biology & medicine 2023 May 4;20(4):297-316
Cancer biology & medicine 2023 May 4;20(4):297-316
Interplay between Furin and Sialoglycans in Modulating Adeno-Associated Viral Cell Entry.
Smith TJ, Fusco RM, Elmore ZC, Asokan A
Journal of virology 2023 May 31;97(5):e0009323
Journal of virology 2023 May 31;97(5):e0009323
Specific Residues in the C-Terminal Domain of the Human Metapneumovirus Phosphoprotein Are Indispensable for Formation of Viral Replication Centers and Regulation of the Function of the Viral Polymerase Complex.
Thompson RE, Edmonds K, Dutch RE
Journal of virology 2023 May 31;97(5):e0003023
Journal of virology 2023 May 31;97(5):e0003023
SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A.
Chen J, Wang Z, Wang T, Cheng J, Zhuang R, Wang W
Bioscience reports 2023 May 31;43(5)
Bioscience reports 2023 May 31;43(5)
Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart.
Aranda-Domene R, Orenes-Piñero E, Arribas-Leal JM, Canovas-Lopez S, Hernández-Cascales J
Cardiovascular diabetology 2023 May 30;22(1):128
Cardiovascular diabetology 2023 May 30;22(1):128
SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma.
Li Z, Liao X, Hu Y, Li M, Tang M, Zhang S, Mo S, Li X, Chen S, Qian W, Feng R, Yu R, Xu Y, Yuan S, Xie C, Li J
Free radical biology & medicine 2023 May 20;201:41-54
Free radical biology & medicine 2023 May 20;201:41-54
FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth.
Wei W, Qin B, Wen W, Zhang B, Luo H, Wang Y, Xu H, Xie X, Liu S, Jiang X, Wang M, Tang Q, Zhang J, Yang R, Fan Z, Lyu H, Lin J, Li K, Lee MH
Signal transduction and targeted therapy 2023 May 19;8(1):187
Signal transduction and targeted therapy 2023 May 19;8(1):187
Transferrin Receptor Is Necessary for Proper Oligodendrocyte Iron Homeostasis and Development.
Cheli VT, Santiago González DA, Wan R, Rosenblum SL, Denaroso GE, Angeliu CG, Smith Z, Wang C, Paez PM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 May 17;43(20):3614-3629
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 May 17;43(20):3614-3629
The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.
Li J, Zhao J, Gan X, Wang Y, Jiang D, Chen L, Wang F, Xu J, Pei H, Huang J, Chen X
Proceedings of the National Academy of Sciences of the United States of America 2023 May 16;120(20):e2303479120
Proceedings of the National Academy of Sciences of the United States of America 2023 May 16;120(20):e2303479120
Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
Zhong X, Li Z, Xu Q, Peng H, Su Y, Le K, Shu Z, Liao Y, Ma Z, Pan X, Xu S, Zhou S
Journal of hypertension 2023 May 1;41(5):775-793
Journal of hypertension 2023 May 1;41(5):775-793
Ubiquitin E3 ligase β-TrCP negatively regulates surface protein of hepatitis B virus.
Tu W, Liu J, Qian F, Zhu L, Li M, Zheng H, Zhu C
Journal of medical virology 2023 Mar;95(3):e28620
Journal of medical virology 2023 Mar;95(3):e28620
Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation.
Fang J, Zhang Y, Huang C, Lu R, Yu J, Chen R, Wang Y, Zhao X, Yu J, Huang J
Oncogene 2023 Mar;42(14):1058-1071
Oncogene 2023 Mar;42(14):1058-1071
QSER1 preserves the suppressive status of the pro-apoptotic genes to prevent apoptosis.
Zhao X, Fang K, Liu X, Yao R, Wang M, Li F, Hao S, He J, Wang Y, Fan M, Huang W, Li Y, Gao C, Lin C, Luo Z
Cell death and differentiation 2023 Mar;30(3):779-793
Cell death and differentiation 2023 Mar;30(3):779-793
Ginsenoside Rg1 regulates thiram-induced chondrocytes' apoptosis and angiogenesis in broiler chickens.
Zhu H, Kulyar MF, Ding Y, Yao W, Mo Q, Li J
Environmental science and pollution research international 2023 Mar;30(12):34188-34202
Environmental science and pollution research international 2023 Mar;30(12):34188-34202
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
Zhao J, Liu J, Liu S, Tian S, Yuan H, Li S
Epigenomics 2023 Mar;15(6):369-383
Epigenomics 2023 Mar;15(6):369-383
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Chen Y, Wang L, Huang ZS, Feng JX, Li SX, Du ZJ, Zhang ZB, Liu J, Yang J, Hu ZM, Wang ZL, Chen J
Andrology 2023 Mar;11(3):591-610
Andrology 2023 Mar;11(3):591-610
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression.
Chen L, Dong W, Zhou M, Yang C, Xiong M, Kazobinka G, Chen Z, Xing Y, Hou T
Cell & bioscience 2023 Mar 6;13(1):45
Cell & bioscience 2023 Mar 6;13(1):45
The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice.
Wu J, Bu D, Wang H, Shen D, Chong D, Zhang T, Tao W, Zhao M, Zhao Y, Fang L, Li P, Xue B, Li CJ
Nature communications 2023 Mar 24;14(1):1634
Nature communications 2023 Mar 24;14(1):1634
Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.
Yuan K, Shen H, Zheng M, Xia F, Li Q, Chen W, Ji M, Yang H, Zhuang X, Cai Z, Min W, Wang X, Xiao Y, Yang P
Journal of medicinal chemistry 2023 Mar 23;66(6):4215-4230
Journal of medicinal chemistry 2023 Mar 23;66(6):4215-4230
The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease.
Cheng Q, Wang D, Lai X, Liu Y, Zuo Y, Zhang W, Lei L, Chen J, Liu H, Wang Y, Liu H, Zheng H, Wu D, Xu Y
Blood 2023 Mar 23;141(12):1474-1488
Blood 2023 Mar 23;141(12):1474-1488
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Xie Y, Shen F, He Y, Guo C, Yang R, Cao H, Pan Q, Fan J
Nutrients 2023 Mar 2;15(5)
Nutrients 2023 Mar 2;15(5)
RIG-I Promotes Tumorigenesis and Confers Radioresistance of Esophageal Squamous Cell Carcinoma by Regulating DUSP6.
Li L, Lv L, Xu JC, He Q, Chang N, Cui YY, Tao ZC, Zhu T, Qian LT
International journal of molecular sciences 2023 Mar 15;24(6)
International journal of molecular sciences 2023 Mar 15;24(6)
Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates.
Fu Y, Jia X, Yuan J, Yang Y, Zhang T, Yu Q, Zhou J, Wang T
Developmental cell 2023 Mar 13;58(5):398-415.e7
Developmental cell 2023 Mar 13;58(5):398-415.e7
P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.
Qiu Q, Guo G, Guo X, Hu X, Yu T, Liu G, Zhang H, Chen Y, She J
Biomedicines 2023 Mar 13;11(3)
Biomedicines 2023 Mar 13;11(3)
Glyphosate-triggered hepatocyte ferroptosis via suppressing Nrf2/GSH/GPX4 axis exacerbates hepatotoxicity.
Liu J, Yang G, Zhang H
The Science of the total environment 2023 Mar 1;862:160839
The Science of the total environment 2023 Mar 1;862:160839
RNA localization to the mitotic spindle is essential for early development and is regulated by kinesin-1 and dynein.
Remsburg CM, Konrad KD, Song JL
Journal of cell science 2023 Mar 1;136(5)
Journal of cell science 2023 Mar 1;136(5)
Kawasaki disease: ubiquitin-specific protease 5 promotes endothelial inflammation via TNFα-mediated signaling.
Huang C, Wang W, Huang H, Jiang J, Ding Y, Li X, Ma J, Hou M, Pu X, Qian G, Lv H
Pediatric research 2023 Jun;93(7):1883-1890
Pediatric research 2023 Jun;93(7):1883-1890
IL-17C neutralization protects the kidney against acute injury and chronic injury.
Zhang F, Yin J, Liu L, Liu S, Zhang G, Kong Y, Wang Y, Wang N, Chen X, Wang F
EBioMedicine 2023 Jun;92:104607
EBioMedicine 2023 Jun;92:104607
Structural basis for FGF hormone signalling.
Chen L, Fu L, Sun J, Huang Z, Fang M, Zinkle A, Liu X, Lu J, Pan Z, Wang Y, Liang G, Li X, Chen G, Mohammadi M
Nature 2023 Jun;618(7966):862-870
Nature 2023 Jun;618(7966):862-870
Magnify is a universal molecular anchoring strategy for expansion microscopy.
Klimas A, Gallagher BR, Wijesekara P, Fekir S, DiBernardo EF, Cheng Z, Stolz DB, Cambi F, Watkins SC, Brody SL, Horani A, Barth AL, Moore CI, Ren X, Zhao Y
Nature biotechnology 2023 Jun;41(6):858-869
Nature biotechnology 2023 Jun;41(6):858-869
Rab26 restricts insulin secretion via sequestering Synaptotagmin-1.
Zhuang R, Zhou Y, Wang Z, Cao Y, Chen J, Xu L, Ren Y, Zheng Y, Wei Z, Qiu H, Li L, Han Y, Yun Y, Chen X, Hong W, Wang T
PLoS biology 2023 Jun;21(6):e3002142
PLoS biology 2023 Jun;21(6):e3002142
Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK.
Li M, Wei X, Xiong J, Feng JW, Zhang CS, Lin SC
Life metabolism 2023 Jun;2(3):load005
Life metabolism 2023 Jun;2(3):load005
GLUT4 degradation by GLUTFOURINH® in mice resembles moderate-obese diabetes of human with hyperglycemia and low lipid accumulation.
Lee SR, Jeong SH, Mukae M, Jeong KJ, Kwun HJ, Hong EJ
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166668
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166668
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
Hu X, Zou R, Zhang Z, Ji J, Li J, Huo XY, Liu D, Ge MX, Cui MK, Wu MZ, Li ZP, Wang Q, Zhang X, Zhang ZR
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194937
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194937
BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion.
Guo K, Shang Y, Wang Z, Li Y, Chen J, Zhu B, Zhang D, Chen J
International immunopharmacology 2023 Jun;119:110201
International immunopharmacology 2023 Jun;119:110201
Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway.
Guo L, Dong Z, Zhang X, Yang Y, Hu X, Ji Y, Li C, Wan S, Xu J, Liu C, Zhang Y, Liu L, Shi Y, Wu Z, Liu Y, Cui H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154765
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154765
Cycloheximide (CHX) Chase Assay to Examine Protein Half-life.
Miao Y, Du Q, Zhang HG, Yuan Y, Zuo Y, Zheng H
Bio-protocol 2023 Jun 5;13(11):e4690
Bio-protocol 2023 Jun 5;13(11):e4690
Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure.
Wang Y, Chen G, Tang Z, Mei X, Lin C, Kang J, Lian J, Lu J, Liu Y, Lan F, Huang W, Zhang D
Molecular human reproduction 2023 Jun 30;29(7)
Molecular human reproduction 2023 Jun 30;29(7)
TFF3 promotes clonogenic survival of colorectal cancer cells through upregulation of EP4 via activation of STAT3.
Yang T, Fu X, Tian RF, Cui HY, Li L, Han JM, Wang SJ
Translational cancer research 2023 Jun 30;12(6):1503-1515
Translational cancer research 2023 Jun 30;12(6):1503-1515
A Potential Anti-Glioblastoma Compound LH20 Induces Apoptosis and Arrest of Human Glioblastoma Cells via CDK4/6 Inhibition.
Wang Y, Li Y, Liu D, Zheng D, Li X, Li C, Huang C, Wang Y, Wang X, Li Q, Xu J
Molecules (Basel, Switzerland) 2023 Jun 28;28(13)
Molecules (Basel, Switzerland) 2023 Jun 28;28(13)
GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail.
Zou X, Ma L, Zhang Y, Zhang Q, Xu C, Zhang D, Chu Y, Zhang J, Li M, Zhang H, Wang J, Peng C, Wei G, Wu Y, Hou Z, Jia H
Cell death & disease 2023 Jun 28;14(6):382
Cell death & disease 2023 Jun 28;14(6):382
The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection.
Hardy A, Bakshi S, Furnon W, MacLean O, Gu Q, Varjak M, Varela M, Aziz MA, Shaw AE, Pinto RM, Cameron Ruiz N, Mullan C, Taggart AE, Da Silva Filipe A, Randall RE, Wilson SJ, Stewart ME, Palmarini M
mBio 2023 Jun 27;14(3):e0010123
mBio 2023 Jun 27;14(3):e0010123
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Cai Y, Chen P, Xu H, Li S, Zhao B, Fan Y, Wang F, Zhang Y
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8.
Nakanishi K, Norimatsu K, Tani A, Matsuoka T, Matsuzaki R, Kakimoto S, Nojima N, Tachibe Y, Kato Y, Inadome M, Kitazato R, Otsuka S, Takada S, Sumizono M, Sakakima H
Neuroscience letters 2023 Jun 21;808:137297
Neuroscience letters 2023 Jun 21;808:137297
Long noncoding RNA HITT coordinates with RGS2 to inhibit PD-L1 translation in T cell immunity.
Lin Q, Liu T, Wang X, Hou G, Xiang Z, Zhang W, Zheng S, Zhao D, Leng Q, Zhang X, Lu M, Guan T, Liu H, Hu Y
The Journal of clinical investigation 2023 Jun 1;133(11)
The Journal of clinical investigation 2023 Jun 1;133(11)
NLRP3 inflammasome inhibition of OP9 cells enhance therapy for inflammatory bowel disease.
Chen Y, Meng W, Ren G, An N, Zhang J, Liu Z, Wu X, Yin W, Hu X, Liu Z, Feng F, Chen Y
Heliyon 2023 Jul;9(7):e18038
Heliyon 2023 Jul;9(7):e18038
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Cai Z, Li Y, Ma M, Wang L, Wang H, Liu M, Jiang C
Oncology reports 2023 Jul;50(1)
Oncology reports 2023 Jul;50(1)
Nucleolar protein treacle ribosome biogenesis factor 1 maintains gastric cancer cell proliferation by regulating R-loop associated DNA replication stress.
Nie X, Zhao C, Zhang Y, Huang W, Zhou Y, Liu H, Nie Y, Xie K, Jia L
Journal of gastroenterology and hepatology 2023 Jul;38(7):1170-1180
Journal of gastroenterology and hepatology 2023 Jul;38(7):1170-1180
COLEC10 Induces Endoplasmic Reticulum Stress by Occupying GRP78 and Inhibits Hepatocellular Carcinoma.
Cai MN, Chen DM, Xiao LX, Li SS, Liao CH, Li J, Huang ZX, Wang JL, Gu YR, Gu L, Huang YH, Lian YF
Laboratory investigation; a journal of technical methods and pathology 2023 Jul;103(7):100130
Laboratory investigation; a journal of technical methods and pathology 2023 Jul;103(7):100130
Protopine Alleviates Dextran Sodium Sulfate-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Regulating Intestinal Microbiota.
Yue M, Huang J, Ma X, Huang P, Liu Y, Zeng J
Molecules (Basel, Switzerland) 2023 Jul 7;28(13)
Molecules (Basel, Switzerland) 2023 Jul 7;28(13)
Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.
Liu N, Konuma T, Sharma R, Wang D, Zhao N, Cao L, Ju Y, Liu D, Wang S, Bosch A, Sun Y, Zhang S, Ji D, Nagatoishi S, Suzuki N, Kikuchi M, Wakamori M, Zhao C, Ren C, Zhou TJ, Xu Y, Meslamani J, Fu S, Umehara T, Tsumoto K, Akashi S, Zeng L, Roeder RG, Walsh MJ, Zhang Q, Zhou MM
Molecular cell 2023 Jul 6;83(13):2206-2221.e11
Molecular cell 2023 Jul 6;83(13):2206-2221.e11
Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-κB/MGMT Axis.
Liao X, Li Z, Zheng H, Qian W, Zhang S, Chen S, Li X, Tang M, Xu Y, Yu R, Li M, Song L, Li J
Molecular cancer research : MCR 2023 Jul 5;21(7):648-663
Molecular cancer research : MCR 2023 Jul 5;21(7):648-663
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.
Festa BP, Siddiqi FH, Jimenez-Sanchez M, Won H, Rob M, Djajadikerta A, Stamatakou E, Rubinsztein DC
Neuron 2023 Jul 5;111(13):2021-2037.e12
Neuron 2023 Jul 5;111(13):2021-2037.e12
The NF-Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer.
Rigillo G, Belluti S, Campani V, Ragazzini G, Ronzio M, Miserocchi G, Bighi B, Cuoghi L, Mularoni V, Zappavigna V, Dolfini D, Mercatali L, Alessandrini A, Imbriano C
Cancer letters 2023 Jul 28;567:216262
Cancer letters 2023 Jul 28;567:216262
Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis.
Huang H, Jing B, Zhu F, Jiang W, Tang P, Shi L, Chen H, Ren G, Xia S, Wang L, Cui Y, Yang Z, Platero AJ, Hutchins AP, Chen M, Worley PF, Xiao B
Cell reports 2023 Jul 25;42(7):112801
Cell reports 2023 Jul 25;42(7):112801
Ethyl acetate extract of Antenoron Filiforme inhibits the proliferation of triple negative breast cancer cells via suppressing Skp2/p21 signaling axis.
Liao Y, Li S, An J, Yu X, Tan X, Gui Y, Wang Y, Huang L, Zhou S, Wang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154856
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154856
Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery.
Wallace NS, Gadbery JE, Cohen CI, Kendall AK, Jackson LP
bioRxiv : the preprint server for biology 2023 Jul 18;
bioRxiv : the preprint server for biology 2023 Jul 18;
Design, Synthesis and Biological Evaluation of Histone Deacetylase Inhibitors Based on Pyrrolo[2,3-d]pyrimidine and Pyrrolo[2,3-b]pyridine Scaffolds.
Mao ND, Gao Y, Dang XW, Duan JL, Hui Z, Che H, Xu Y, Zhang H, He X, Garrido C, Ye XY
ChemMedChem 2023 Jul 17;18(14):e202200683
ChemMedChem 2023 Jul 17;18(14):e202200683
KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy.
Li J, Yu D, He C, Yu Q, Huo Z, Zhang Y, Zhang S
Cell death & disease 2023 Jul 1;14(7):393
Cell death & disease 2023 Jul 1;14(7):393
VASN promotes colorectal cancer progression by activating the YAP/TAZ and AKT signaling pathways via YAP.
Liang W, Zuo J, Liu M, Su Y, Guo B, Hou J, Xing Q, Peng Y, Fang L, Cao Y, Shan J, Sun R, Zhao J, Wang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22688
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22688
Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
Qin J, Huang T, Wang Z, Zhang X, Wang J, Dang Q, Cui D, Wang X, Zhai Y, Zhao L, Lu G, Shao C, Li S, Liu H, Liu Z
Cell death and differentiation 2023 Jan;30(1):184-194
Cell death and differentiation 2023 Jan;30(1):184-194
Methotrexate and Triptolide regulate Notch signaling pathway by targeting the Nedd4-Numb axis.
Wu Q, Chen X, Qiao C, Cao X, Du Q, Yuan Y, Zuo Y, Miao Y, Zheng Z, Zhang T, Zang L, Yang X, Shi W, Xie Z, Xu Y, Wu D, Wen C, Zheng H
International immunopharmacology 2023 Jan;114:109595
International immunopharmacology 2023 Jan;114:109595
Ivacaftor-Mediated Potentiation of ABCB4 Missense Mutations Affecting Critical Motifs of the NBDs: Repositioning Perspectives for Hepatobiliary Diseases.
Delaunay JL, Elbahnsi A, Bruneau A, Madry C, Durand-Schneider AM, Stary A, Housset C, Gautheron J, Callebaut I, Aït-Slimane T
International journal of molecular sciences 2023 Jan 8;24(2)
International journal of molecular sciences 2023 Jan 8;24(2)
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability.
Caballero-Ruiz B, Gkotsi DS, Ollerton H, Morales-Alcala CC, Bordone R, Jenkins GML, Di Magno L, Canettieri G, Riobo-Del Galdo NA
Cancers 2023 Jan 6;15(2)
Cancers 2023 Jan 6;15(2)
Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease.
Hu J, Chen Q, Zhu H, Hou L, Liu W, Yang Q, Shen H, Chai G, Zhang B, Chen S, Cai Z, Wu C, Hong F, Li H, Chen S, Xiao N, Wang ZX, Zhang X, Wang B, Zhang L, Mo W
Neuron 2023 Jan 4;111(1):15-29.e8
Neuron 2023 Jan 4;111(1):15-29.e8
SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2.
Jiang X, Liu K, Jiang H, Yin H, Wang ED, Cheng H, Yuan F, Xiao F, Wang F, Lu W, Peng B, Shu Y, Li X, Chen S, Guo F
Cell reports 2023 Jan 31;42(1):111984
Cell reports 2023 Jan 31;42(1):111984
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74
Cell death & disease 2023 Jan 31;14(1):74
ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth.
Zuo Z, Liu J, Sun Z, Cheng YW, Ewing M, Bugge TH, Finkel T, Leppla SH, Liu S
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 3;120(1):e2211927120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 3;120(1):e2211927120
[WITHDRAWN] Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction.
Tatekoshi Y, Shapiro JS, Liu M, Bianco GM, Tatekoshi A, De Jesus A, Koleini N, Wasserstrom JA, Dillmann WH, Weinberg SE, Ardehali H
Research square 2023 Jan 25;
Research square 2023 Jan 25;
AmAtg2B-Mediated Lipophagy Regulates Lipolysis of Pupae in Apis mellifera.
Chen WF, Wang HF, Wang Y, Liu ZG, Xu BH
International journal of molecular sciences 2023 Jan 20;24(3)
International journal of molecular sciences 2023 Jan 20;24(3)
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
Zhu X, Hao W, Liu Z, Song Y, Hao C, Wu S, Lu X, Yang J, Jin C
Ecotoxicology and environmental safety 2023 Jan 1;249:114373
Ecotoxicology and environmental safety 2023 Jan 1;249:114373
Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway.
Yang DG, Gao YY, Yin ZQ, Wang XR, Meng XS, Zou TF, Duan YJ, Chen YL, Liao CZ, Xie ZL, Fan XD, Sun L, Han JH, Yang XX
Acta pharmacologica Sinica 2023 Feb;44(2):308-320
Acta pharmacologica Sinica 2023 Feb;44(2):308-320
STAT3/Mitophagy Axis Coordinates Macrophage NLRP3 Inflammasome Activation and Inflammatory Bone Loss.
Zhu L, Wang Z, Sun X, Yu J, Li T, Zhao H, Ji Y, Peng B, Du M
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Feb;38(2):335-353
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Feb;38(2):335-353
Effects of ferroptosis in myocardial ischemia/reperfusion model of rat and its association with Sestrin 1.
Yang F, Wang W, Zhang Y, Nong J, Zhang L
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Feb;32(2):219-231
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Feb;32(2):219-231
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers.
Zheng S, Wang X, Liu H, Zhao D, Lin Q, Jiang Q, Li L, Hu Y
Cell death and differentiation 2023 Feb;30(2):327-340
Cell death and differentiation 2023 Feb;30(2):327-340
Mitochondria-localized lncRNA HITT inhibits fusion by attenuating formation of mitofusin-2 homotypic or heterotypic complexes.
Wang X, Zhang Y, Lin Q, Zhao K, Zhu D, Hu Y
The Journal of biological chemistry 2023 Feb;299(2):102825
The Journal of biological chemistry 2023 Feb;299(2):102825
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma.
Wang X, Zhang Q, Zhou J, Xiao Z, Liu J, Deng S, Hong X, Huang W, Cai M, Guo Y, Huang J, Wang Y, Lin L, Zhu K
Journal for immunotherapy of cancer 2023 Feb;11(2)
Journal for immunotherapy of cancer 2023 Feb;11(2)
Effects of different remote ischemia perconditioning methods on cerebral infarct volume and neurological impairment in rats.
Otsuka S, Itashiki Y, Tani A, Matsuoka T, Takada S, Matsuzaki R, Nakanishi K, Norimatsu K, Tachibe Y, Kitazato R, Nojima N, Kakimoto S, Kikuchi K, Maruyama I, Sakakima H
Scientific reports 2023 Feb 7;13(1):2158
Scientific reports 2023 Feb 7;13(1):2158
Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1-CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice.
Yang Y, Ding T, Xiao G, Huang J, Luo D, Yue M, Su Y, Jiang S, Zeng J, Liu Y
Biomedicines 2023 Feb 5;11(2)
Biomedicines 2023 Feb 5;11(2)
Novel ELAC2 Mutations in Individuals Presenting with Variably Severe Neurological Disease in the Presence or Absence of Cardiomyopathy.
Cafournet C, Zanin S, Guimier A, Hully M, Assouline Z, Barcia G, de Lonlay P, Steffann J, Munnich A, Bonnefont JP, Rötig A, Ruzzenente B, Metodiev MD
Life (Basel, Switzerland) 2023 Feb 4;13(2)
Life (Basel, Switzerland) 2023 Feb 4;13(2)
PGRMC1 Ablation Protects from Energy-Starved Heart Failure by Promoting Fatty Acid/Pyruvate Oxidation.
Lee SR, Mukae M, Jeong KJ, Park SH, Shin HJ, Kim SW, Won YS, Kwun HJ, Baek IJ, Hong EJ
Cells 2023 Feb 27;12(5)
Cells 2023 Feb 27;12(5)
LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei.
Zhu J, Chen K, Sun YH, Ye W, Liu J, Zhang D, Su N, Wu L, Kou X, Zhao Y, Wang H, Gao S, Kang L
Nature communications 2023 Feb 21;14(1):957
Nature communications 2023 Feb 21;14(1):957
Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.
Mun DJ, Goo BS, Suh BK, Hong JH, Woo Y, Kim SJ, Kim S, Lee SB, Won Y, Yoo JY, Cho E, Jang EJ, Nhung TTM, Triet HM, An H, Lee H, Nguyen MD, Park SY, Baek ST, Park SK
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 21;120(8):e2214507120
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 21;120(8):e2214507120
ERRα Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis.
Tang S, Ma J, Su P, Lei H, Tong Y, Cai L, Xu S, Mao X, Sun P
International journal of molecular sciences 2023 Feb 16;24(4)
International journal of molecular sciences 2023 Feb 16;24(4)
Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis.
Fan R, Zhou Y, Chen X, Zhong X, He F, Peng W, Li L, Wang X, Xu Y
Microbiology spectrum 2023 Feb 14;11(1):e0328822
Microbiology spectrum 2023 Feb 14;11(1):e0328822
Repositioning linifanib as a potent anti-necroptosis agent for sepsis.
Yu L, Yang K, He X, Li M, Gao L, Zha Y
Cell death discovery 2023 Feb 10;9(1):57
Cell death discovery 2023 Feb 10;9(1):57
Stimulation of functional recovery via neurorepair mechanisms by the traditional Japanese Kampo medicine, Ninjin'yoeito, and physical exercise in a rat ischemic stroke model.
Tani A, Sakakima H, Otsuka S, Mizuno K, Nakanishi K, Norimatsu K, Takada S, Matsuoka T, Matsuzaki R, Nakakogawa T, Maruyama I
Journal of ethnopharmacology 2023 Feb 10;302(Pt B):115927
Journal of ethnopharmacology 2023 Feb 10;302(Pt B):115927
Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation.
Zhang B, Hou Q, Zhang X, Ma Y, Yuan J, Li S, Zhao X, Sun L, Wang H, Zheng H
Free radical biology & medicine 2023 Feb 1;195:298-308
Free radical biology & medicine 2023 Feb 1;195:298-308
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism.
Yunusa S, Hassan Z, Müller CP
Pharmacological reports : PR 2023 Dec;75(6):1488-1501
Pharmacological reports : PR 2023 Dec;75(6):1488-1501
Ame-miR-980-3p participates in autophagy-mediated midgut remodelling in Apis mellifera via targeting Atg2B.
Chen WF, Chi XP, Song HY, Wang HF, Wang Y, Liu ZG, Xu BH
Insect molecular biology 2023 Dec;32(6):748-760
Insect molecular biology 2023 Dec;32(6):748-760
CDC20 promotes radioresistance of prostate cancer by activating Twist1 expression.
Yang C, Ge Y, Zang Y, Xu M, Jin L, Wang Y, Xu X, Xue B, Wang Z, Wang L
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1584-1595
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1584-1595
High cholesterol diet-induced testicular dysfunction in rats.
Liu L, Zhang M, Jiang F, Luo D, Liu S, Su Y, Guan Q, Yu C
Hormones (Athens, Greece) 2023 Dec;22(4):685-694
Hormones (Athens, Greece) 2023 Dec;22(4):685-694
DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells.
Chen Z, Zhang L, Yang Y, Liu H, Kang X, Nie Y, Fan D
Epigenetics 2023 Dec;18(1):2254976
Epigenetics 2023 Dec;18(1):2254976
Ceftazidime reduces cellular Skp2 to promote type-I interferon activity.
Qiao C, Huang F, He J, Wu Q, Zheng Z, Zhang T, Miao Y, Yuan Y, Chen X, Du Q, Xu Y, Wu D, Yu Z, Zheng H
Immunology 2023 Dec;170(4):527-539
Immunology 2023 Dec;170(4):527-539
Identification of basement membrane markers in diabetic kidney disease and immune infiltration by using bioinformatics analysis and experimental verification.
Shi R, Zhao WM, Zhu L, Wang RF, Wang DG
IET systems biology 2023 Dec;17(6):316-326
IET systems biology 2023 Dec;17(6):316-326
Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis.
Yu W, Hu Y, Liu Z, Guo K, Ma D, Peng M, Wang Y, Zhang J, Zhang X, Wang P, Zhang J, Liu P, Lu J
Acta pharmaceutica Sinica. B 2023 Dec;13(12):4875-4892
Acta pharmaceutica Sinica. B 2023 Dec;13(12):4875-4892
Hydroxypropyl-β-cyclodextrin inhibits the development of triple negative breast cancer by enhancing antitumor immunity.
Zhu M, Zhao Q, Zhang W, Xu H, Zhang B, Zhang S, Duan Y, Liao C, Yang X, Chen Y
International immunopharmacology 2023 Dec;125(Pt A):111168
International immunopharmacology 2023 Dec;125(Pt A):111168
Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
Xiong H, Ye J, Luo Q, Li W, Xu N, Yang H
Cellular signalling 2023 Dec;112:110901
Cellular signalling 2023 Dec;112:110901
Identification of nonfunctional PABPC1L causing oocyte maturation abnormalities and early embryonic arrest in female primary infertility.
Wang X, Zhou R, Lu X, Dai S, Liu M, Jiang C, Yang Y, Shen Y, Wang Y, Liu H
Clinical genetics 2023 Dec;104(6):648-658
Clinical genetics 2023 Dec;104(6):648-658
Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.
Stewart H, Palmulli R, Johansen KH, McGovern N, Shehata OM, Carnell GW, Jackson HK, Lee JS, Brown JC, Burgoyne T, Heeney JL, Okkenhaug K, Firth AE, Peden AA, Edgar JR
EMBO reports 2023 Dec 6;24(12):e57224
EMBO reports 2023 Dec 6;24(12):e57224
CX43 down-regulation promotes cell aggressiveness and 5-fluorouracil-resistance by attenuating cell stiffness in colorectal carcinoma.
Han Y, Wang H, Chen H, Tan T, Wang Y, Yang H, Ding Y, Wang S
Cancer biology & therapy 2023 Dec 31;24(1):2221879
Cancer biology & therapy 2023 Dec 31;24(1):2221879
Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation.
Lei M, Wang W, Zhang H, Gong J, Wang Z, Cai H, Yang X, Wang S, Ma C
Cell reports 2023 Dec 26;42(12):113522
Cell reports 2023 Dec 26;42(12):113522
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
Xu Z, Tian M, Tan Q, Hao P, Gao Z, Li C, Jin N
International journal of molecular sciences 2023 Dec 26;25(1)
International journal of molecular sciences 2023 Dec 26;25(1)
Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration.
Zhao B, Cowan CM, Coutts JA, Christy DD, Saraph A, Hsueh SCC, Plotkin SS, Mackenzie IR, Kaplan JM, Cashman NR
Acta neuropathologica communications 2023 Dec 18;11(1):200
Acta neuropathologica communications 2023 Dec 18;11(1):200
FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation.
Ouyang Y, Ou Z, Zhong W, Yang J, Fu S, Ouyang N, Chen J, Xu L, Wu D, Qian J, Lin Y, Lin T, Huang J
Cancer research 2023 Dec 15;83(24):4030-4046
Cancer research 2023 Dec 15;83(24):4030-4046
The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis.
Renaud CCN, Trillet K, Jardine J, Merlet L, Renoult O, Laurent-Blond M, Catinaud Z, Pecqueur C, Gavard J, Bidère N
Communications biology 2023 Dec 15;6(1):1271
Communications biology 2023 Dec 15;6(1):1271
FGIN-1-27 Mitigates Radiation-induced Mitochondrial Hyperfunction and Cellular Hyperactivation in Cultured Astrocytes.
Zhang S, Deng Z, Qiu Y, Lu G, Wu J, Huang H
Neuroscience 2023 Dec 15;535:23-35
Neuroscience 2023 Dec 15;535:23-35
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
Wang Z, Cai H, Li Z, Sun W, Zhao E, Cui H
Clinical epigenetics 2023 Dec 13;15(1):192
Clinical epigenetics 2023 Dec 13;15(1):192
CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing.
Wang C, Xu L, Du C, Yun H, Wang K, Liu H, Ye M, Fan J, Zhou Y, Cheng H
The EMBO journal 2023 Dec 11;42(24):e114051
The EMBO journal 2023 Dec 11;42(24):e114051
Combined Aurora Kinase A and CHK1 Inhibition Enhances Radiosensitivity of Triple-Negative Breast Cancer Through Induction of Apoptosis and Mitotic Catastrophe Associated With Excessive DNA Damage.
Li C, Liao J, Wang X, Chen FX, Guo X, Chen X
International journal of radiation oncology, biology, physics 2023 Dec 1;117(5):1241-1254
International journal of radiation oncology, biology, physics 2023 Dec 1;117(5):1241-1254
The outer membrane protein of Fusobacterium necrophorum, 43K OMP, stimulates inflammatory cytokine production through nuclear factor kappa B activation.
He X, Liu J, Jiang K, Lian S, Shi Y, Fu S, Zhao P, Xiao J, Sun D, Guo D
Anaerobe 2023 Aug;82:102768
Anaerobe 2023 Aug;82:102768
Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress.
Croushore EE, Koppenhafer SL, Goss KL, Geary EL, Gordon DJ
Cancer research communications 2023 Aug;3(8):1580-1593
Cancer research communications 2023 Aug;3(8):1580-1593
Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma.
Cun Y, An S, Zheng H, Lan J, Chen W, Luo W, Yao C, Li X, Huang X, Sun X, Wu Z, Hu Y, Li Z, Zhang S, Wu G, Yang M, Tang M, Yu R, Liao X, Gao G, Zhao W, Wang J, Li J
Genomics, proteomics & bioinformatics 2023 Aug;21(4):707-728
Genomics, proteomics & bioinformatics 2023 Aug;21(4):707-728
Restoration of energy homeostasis under oxidative stress: Duo synergistic AMPK pathways regulating arginine kinases.
Zhang N, Meng X, Jiang H, Ge H, Qian K, Zheng Y, Park Y, Wang J
PLoS genetics 2023 Aug;19(8):e1010843
PLoS genetics 2023 Aug;19(8):e1010843
Dppa3 Improves the Germline Competence of Pluripotent Stem Cells.
Liu S, Zhao S, Zhang C, Tian C, Wang D, Yu H, Li Z, Liu L, Liu N
Stem cell reviews and reports 2023 Aug;19(6):1845-1855
Stem cell reviews and reports 2023 Aug;19(6):1845-1855
Identification and validation of Birc5 as a novel activated cell cycle program biomarker associated with infiltration of immunosuppressive myeloid-derived suppressor cells in hepatocellular carcinoma.
Liu Y, Chen X, Luo W, Zhao Y, Nashan B, Huang L, Yuan X
Cancer medicine 2023 Aug;12(15):16370-16385
Cancer medicine 2023 Aug;12(15):16370-16385
A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma.
Schmidt AV, Monga SP, Prochownik EV, Goetzman ES
International journal of molecular sciences 2023 Aug 9;24(16)
International journal of molecular sciences 2023 Aug 9;24(16)
Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells-derived neural rosettes.
Binó L, Čajánek L
Scientific reports 2023 Aug 9;13(1):12884
Scientific reports 2023 Aug 9;13(1):12884
ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.
Wang Y, Que H, Li C, Wu Z, Jian F, Zhao Y, Tang H, Chen Y, Gao S, Wong CCL, Li Y, Zhao C, Rong Y
The Journal of cell biology 2023 Aug 7;222(8)
The Journal of cell biology 2023 Aug 7;222(8)
UbcH5c-dependent activation of DNA-dependent protein kinase in response to replication-mediated DNA double-strand breaks.
Sakasai R, Matsui T, Sunatani Y, Iwabuchi K
Biochemical and biophysical research communications 2023 Aug 6;668:42-48
Biochemical and biophysical research communications 2023 Aug 6;668:42-48
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Wang H, Qiu Y, Zhang H, Chang N, Hu Y, Chen J, Hu R, Liao P, Li Z, Yang Y, Cen Q, Ding X, Li M, Xie X, Li Y
Cell death & disease 2023 Aug 4;14(8):498
Cell death & disease 2023 Aug 4;14(8):498
Tissue pleiotropic effect of biotin and prebiotic supplementation in established obesity.
Voland L, Yuan M, Lecoutre S, Debédat J, Pelloux V, Pradeau M, Coles E, Merabtene F, Zhang C, Mardinoglu A, Le Roy T, Soula H, Clément K
American journal of physiology. Endocrinology and metabolism 2023 Aug 30;
American journal of physiology. Endocrinology and metabolism 2023 Aug 30;
Homotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics.
Yun H, Jung M, Lee H, Jung S, Kim T, Kim N, Park SY, Kim WJ, Mun JY, Yoo JY
EMBO reports 2023 Aug 3;24(8):e56538
EMBO reports 2023 Aug 3;24(8):e56538
Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.
Li Y, Wang H, Sun B, Su G, Cang Y, Zhao L, Zhao S, Li Y, Mao B, Ma P
Cell death & disease 2023 Aug 3;14(8):494
Cell death & disease 2023 Aug 3;14(8):494
Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8(+) T cell exhaustion via TRIM14-IFN-β axis.
Ma X, Wang Q, Sun C, Agarwal I, Wu H, Chen J, Zhao C, Qi G, Teng Q, Yuan C, Yan S, Peng J, Li R, Song K, Zhang Q, Kong B
Cell reports 2023 Aug 29;42(8):112944
Cell reports 2023 Aug 29;42(8):112944
Subcellular localization shapes the fate of RNA polymerase III.
Tian K, Wang R, Huang J, Wang H, Ji X
Cell reports 2023 Aug 29;42(8):112941
Cell reports 2023 Aug 29;42(8):112941
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.
Liu S, Guo R, Xu H, Yang J, Luo H, Yeung SJ, Li K, Lee MH, Yang R
Cell reports 2023 Aug 29;42(8):112870
Cell reports 2023 Aug 29;42(8):112870
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.
Lin Z, Li S, Xiao H, Xu Z, Li C, Zeng J, Wang S, Liu Z, Huang H
Cell reports 2023 Aug 29;42(8):112851
Cell reports 2023 Aug 29;42(8):112851
Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression.
Chang LH, Wu SC, Chen CH, Chen JW, Huang WC, Wu CW, Lin YS, Chen YJ, Chang JK, Ho ML
International journal of molecular sciences 2023 Aug 29;24(17)
International journal of molecular sciences 2023 Aug 29;24(17)
The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters.
Lv X, Xiao W, Lai Y, Zhang Z, Zhang H, Qiu C, Hou L, Chen Q, Wang D, Gao Y, Song Y, Shui X, Chen Q, Qin R, Liang S, Zeng W, Shi A, Li J, Wu L
Nature communications 2023 Aug 29;14(1):5267
Nature communications 2023 Aug 29;14(1):5267
SOSSB1 and SOSSB2 mutually regulate protein stability through competitive binding of SOSSA.
Zhang Q, Hao R, Chen H, Zhou G
Cell death discovery 2023 Aug 28;9(1):319
Cell death discovery 2023 Aug 28;9(1):319
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling.
Chen ZR, Hong Y, Wen SH, Zhan YQ, Huang WQ
Anesthesia and analgesia 2023 Aug 1;137(2):426-439
Anesthesia and analgesia 2023 Aug 1;137(2):426-439
Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway.
Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, Zhou Z
Drug development research 2023 Apr;84(2):211-225
Drug development research 2023 Apr;84(2):211-225
Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1.
Huo P, Li M, Le J, Zhu C, Yao J, Zhang S
Systems biology in reproductive medicine 2023 Apr;69(2):153-165
Systems biology in reproductive medicine 2023 Apr;69(2):153-165
Muscleblind-like 2 knockout shifts adducin 1 isoform expression and alters dendritic spine dynamics of cortical neurons during brain development.
Huang CW, Lee KY, Lin PT, Nian FS, Cheng HY, Chang CH, Liao CY, Su YL, Seah C, Li C, Chen YF, Lee MH, Tsai JW
Neuropathology and applied neurobiology 2023 Apr;49(2):e12890
Neuropathology and applied neurobiology 2023 Apr;49(2):e12890
C4orf19 inhibits colorectal cancer cell proliferation by competitively binding to Keap1 with TRIM25 via the USP17/Elk-1/CDK6 axis.
Huang S, Li J, Wu S, Zheng Z, Wang C, Li H, Zhao L, Zhang X, Huang H, Huang C, Xie Q
Oncogene 2023 Apr;42(17):1333-1346
Oncogene 2023 Apr;42(17):1333-1346
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311
Cell research 2023 Apr;33(4):299-311
MiR-216a-3p inhibits the proliferation and invasion of fibroblast-like synoviocytes by targeting dual-specificity phosphatase 5.
Ni R, Liu H, Song G, Fu X, Deng B, Xu Z, Dai S, Huang G
International journal of rheumatic diseases 2023 Apr;26(4):699-709
International journal of rheumatic diseases 2023 Apr;26(4):699-709
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Koma R, Shibaguchi T, Araiso Y, Yamada T, Nonaka Y, Jue T, Masuda K
Physiological reports 2023 Apr;11(7):e15632
Physiological reports 2023 Apr;11(7):e15632
Knockdown of KDM5B Leads to DNA Damage and Cell Cycle Arrest in Granulosa Cells via MTF1.
Yang Y, Cai Y, Guo J, Dai K, Liu L, Chen Z, Wang F, Deng M
Current issues in molecular biology 2023 Apr 7;45(4):3219-3237
Current issues in molecular biology 2023 Apr 7;45(4):3219-3237
Vitamin C promotes ACE2 degradation and protects against SARS-CoV-2 infection.
Zuo Y, Zheng Z, Huang Y, He J, Zang L, Ren T, Cao X, Miao Y, Yuan Y, Liu Y, Ma F, Dai J, Tian S, Ding Q, Zheng H
EMBO reports 2023 Apr 5;24(4):e56374
EMBO reports 2023 Apr 5;24(4):e56374
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.
Taffoni C, Marines J, Chamma H, Guha S, Saccas M, Bouzid A, Valadao AC, Maghe C, Jardine J, Park MK, Polak K, De Martino M, Vanpouille-Box C, Del Rio M, Gongora C, Gavard J, Bidère N, Song MS, Pineau D, Hugnot JP, Kissa K, Fontenille L, Blanchet FP, Vila IK, Laguette N
The EMBO journal 2023 Apr 3;42(7):e111961
The EMBO journal 2023 Apr 3;42(7):e111961
Vitamin D3 and Lactobacillus rhamnosus GG/p40 Synergize to Protect Mice From Colitis by Promoting Vitamin D Receptor Expression and Epithelial Proliferation.
Chen D, Tang H, Li Y, Yang H, Wang H, Tan B, Qian J
Inflammatory bowel diseases 2023 Apr 3;29(4):620-632
Inflammatory bowel diseases 2023 Apr 3;29(4):620-632
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy.
Gok MO, Connor OM, Wang X, Menezes CJ, Llamas CB, Mishra P, Friedman JR
The Journal of cell biology 2023 Apr 3;222(4)
The Journal of cell biology 2023 Apr 3;222(4)
TRAF6 Promotes PRMT5 Activity in a Ubiquitination-Dependent Manner.
Liu L, Yin S, Gan W
Cancers 2023 Apr 27;15(9)
Cancers 2023 Apr 27;15(9)
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports 2023 Apr 25;42(4):112349
Cell reports 2023 Apr 25;42(4):112349
CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis.
Zhang D, Zhang Y, Zou X, Li M, Zhang H, Du Y, Wang J, Peng C, Dong C, Hou Z
Cell death & disease 2023 Apr 24;14(4):288
Cell death & disease 2023 Apr 24;14(4):288
RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits.
Li Y, Huang J, Bao L, Zhu J, Duan W, Zheng H, Wang H, Jiang Y, Liu W, Zhang M, Yu Y, Yi C, Ji X
Molecular cell 2023 Apr 20;83(8):1280-1297.e11
Molecular cell 2023 Apr 20;83(8):1280-1297.e11
Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.
Ren KW, Yu XH, Gu YH, Xie X, Wang Y, Wang SH, Li HH, Bi HL
Frontiers in cardiovascular medicine 2022;9:957903
Frontiers in cardiovascular medicine 2022;9:957903
Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction.
Cui WW, Ye C, Wang KX, Yang X, Zhu PY, Hu K, Lan T, Huang LY, Wang W, Gu B, Yan C, Ma P, Qi SH, Luo L
Frontiers in cardiovascular medicine 2022;9:864188
Frontiers in cardiovascular medicine 2022;9:864188
Solamargine Alleviated UVB-Induced Inflammation and Melanogenesis in Human Keratinocytes and Melanocytes via the p38 MAPK Signaling Pathway, a Promising Agent for Post-inflammatory Hyperpigmentation.
Zhao J, Dan Y, Liu Z, Wang Q, Jiang M, Zhang C, Sheu HM, Lin CS, Xiang L
Frontiers in medicine 2022;9:812653
Frontiers in medicine 2022;9:812653
lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization.
Zhao K, Wang X, Zhao D, Lin Q, Zhang Y, Hu Y
Research (Washington, D.C.) 2022;2022:9854904
Research (Washington, D.C.) 2022;2022:9854904
Resveratrol Synergistically Promotes BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells.
Wang Y, Xia C, Chen Y, Jiang T, Hu Y, Gao Y
Stem cells international 2022;2022:8124085
Stem cells international 2022;2022:8124085
STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages.
Wu XY, Chen YJ, Liu CA, Gong JH, Xu XS
Oxidative medicine and cellular longevity 2022;2022:8123157
Oxidative medicine and cellular longevity 2022;2022:8123157
Catalpol Regulates Oligodendrocyte Regeneration and Remyelination by Activating the GEF-Cdc42/Rac1 Signaling Pathway in EAE Mice.
Wu M, Kang Q, Kang Y, Tong Y, Yang T, Fan Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7074157
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7074157
Peripheral Transplantation of Mesenchymal Stem Cells at Sepsis Convalescence Improves Cognitive Function of Sepsis Surviving Mice.
Tan L, Cheng Y, Wang H, Tong J, Qin X
Oxidative medicine and cellular longevity 2022;2022:6897765
Oxidative medicine and cellular longevity 2022;2022:6897765
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Chen P, Yang J, Wu N, Han B, Kastelic JP, Gao J
Oxidative medicine and cellular longevity 2022;2022:2549772
Oxidative medicine and cellular longevity 2022;2022:2549772
Conditional deletion of MAD2B in forebrain neurons enhances hippocampus-dependent learning and memory in mice.
Cheng L, Su Y, Zhi K, Xie Y, Zhang C, Meng X
Frontiers in cellular neuroscience 2022;16:956029
Frontiers in cellular neuroscience 2022;16:956029
Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson's Disease.
Wang Y, Luo K, Li J, Liao Y, Liao C, Chen WS, Chen M, Ao L
Frontiers in cellular neuroscience 2022;16:884788
Frontiers in cellular neuroscience 2022;16:884788
Healthy Serum-Derived Exosomes Improve Neurological Outcomes and Protect Blood-Brain Barrier by Inhibiting Endothelial Cell Apoptosis and Reversing Autophagy-Mediated Tight Junction Protein Reduction in Rat Stroke Model.
Huang LY, Song JX, Cai H, Wang PP, Yin QL, Zhang YD, Chen J, Li M, Song JJ, Wang YL, Luo L, Wang W, Qi SH
Frontiers in cellular neuroscience 2022;16:841544
Frontiers in cellular neuroscience 2022;16:841544
LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis.
Li MZ, Wen XY, Liu XQ, Wang YQ, Yan L
Journal of inflammation research 2022;15:5707-5720
Journal of inflammation research 2022;15:5707-5720
Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
Wang L, Pu W, Wang C, Lei L, Li H
Journal of oral microbiology 2022;14(1):2015130
Journal of oral microbiology 2022;14(1):2015130
SIX1 Predicts Poor Prognosis and Facilitates the Progression of Non-small Lung Cancer via Activating the Notch Signaling Pathway.
Huang S, Lin W, Wang L, Gao Y, Yuan X, Zhang P, Chen Y, Chu Q
Journal of Cancer 2022;13(2):527-540
Journal of Cancer 2022;13(2):527-540
Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway.
Huo XY, Lei LR, Guo WX, Hu YJ, Kuang QX, Liu MD, Peng W, Dai YF, Wang D, Gu YC, Guo DL, Deng Y
Frontiers in microbiology 2022;13:999996
Frontiers in microbiology 2022;13:999996
Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent manner.
Ran XH, Zhu JW, Chen YY, Ni RZ, Mu D
Frontiers in immunology 2022;13:947272
Frontiers in immunology 2022;13:947272
Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine.
Huang PP, Zhu WQ, Xiao JM, Zhang YQ, Li R, Yang Y, Shen L, Luo F, Dai W, Lian PA, Tang YX, Ran JL, Huang XS
Frontiers in pharmacology 2022;13:935362
Frontiers in pharmacology 2022;13:935362
Effect of Platycodon grandiflorus Polysaccharide on M1 Polarization Induced by Autophagy Degradation of SOCS1/2 Proteins in 3D4/21 Cells.
Li L, Chen X, Lv M, Cheng Z, Liu F, Wang Y, Zhou A, Liu J, Zhao X
Frontiers in immunology 2022;13:934084
Frontiers in immunology 2022;13:934084
Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.
Tan Z, Si Y, Yu Y, Ding J, Huang L, Xu Y, Zhang H, Lu Y, Wang C, Yu B, Yuan L
Frontiers in pharmacology 2022;13:917428
Frontiers in pharmacology 2022;13:917428
Genome-Wide Analysis of the Indispensable Role of Non-structural Proteins in the Replication of SARS-CoV-2.
Jin Y, Ouyang M, Yu T, Zhuang J, Wang W, Liu X, Duan F, Guo D, Peng X, Pan JA
Frontiers in microbiology 2022;13:907422
Frontiers in microbiology 2022;13:907422
Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes.
Lin Z, Li Z, Guo Z, Cao Y, Li J, Liu P, Li Z
Frontiers in pharmacology 2022;13:887991
Frontiers in pharmacology 2022;13:887991
Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.
Xie Y, Cao Y, Guo CJ, Guo XY, He YF, Xu QY, Shen F, Pan Q
Frontiers in genetics 2022;13:884037
Frontiers in genetics 2022;13:884037
TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.
Shi B, Hao Y, Li W, Dong H, Xu M, Gao P
Frontiers in immunology 2022;13:883885
Frontiers in immunology 2022;13:883885
Worenine Prevents Solar Ultraviolet-Induced Sunburn by Inhibiting JNK2.
Xiao J, Lu H, Ma T, Ni X, Chang T, Liu M, Li N, Lu P, Ke C, Tian Q, Zou L, Wang F, Wang W, Zhang L, Yuan P, Liu L, Zhang J, Shi F, Duan Q, Zhu F
Frontiers in pharmacology 2022;13:881042
Frontiers in pharmacology 2022;13:881042
Identification and Characterization of BmNPV m6A Sites and Their Possible Roles During Viral Infection.
Zhang X, Zhang Y, Pan J, Gong C, Hu X
Frontiers in immunology 2022;13:869313
Frontiers in immunology 2022;13:869313
BmCPV-Derived Circular DNA vcDNA-S7 Mediated by Bombyx mori Reverse Transcriptase (RT) Regulates BmCPV Infection.
Zhu M, Pan J, Tong X, Qiu Q, Zhang X, Zhang Y, Sun S, Feng Y, Xue R, Cao G, Hu X, Gong C
Frontiers in immunology 2022;13:861007
Frontiers in immunology 2022;13:861007
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Chen R, Zeng J, Li C, Xiao H, Li S, Lin Z, Huang K, Shen J, Huang H
Frontiers in pharmacology 2022;13:853383
Frontiers in pharmacology 2022;13:853383
N-Acetyldopamine Dimer Attenuates DSS-Induced Ulcerative Colitis by Suppressing NF-κB and MAPK Pathways.
Huang LJ, Wang YM, Gong LQ, Hu C, Gui Y, Zhang C, Tan X, Yu XK, Liao YL, Luo Y, Tang YQ, Dai YF, Deng Y, Wang D, Guo DL
Frontiers in pharmacology 2022;13:842730
Frontiers in pharmacology 2022;13:842730
Induction of Collagen I by CXCL10 in Ovarian Theca-Stroma Cells via the JNK Pathway.
Wang C, Sun Y
Frontiers in endocrinology 2022;13:823740
Frontiers in endocrinology 2022;13:823740
TRIM67 Suppresses TNFalpha-Triggered NF-kB Activation by Competitively Binding Beta-TrCP to IkBa.
Fan W, Liu X, Zhang J, Qin L, Du J, Li X, Qian S, Chen H, Qian P
Frontiers in immunology 2022;13:793147
Frontiers in immunology 2022;13:793147
The involvement of the primo vascular system in local enteritis and its modification by electroacupuncture.
Nan S, Wan J, Lei Q, Wang X, Ma N, Yin R, Zhu J, Ding M, Ding Y
Frontiers in immunology 2022;13:1072996
Frontiers in immunology 2022;13:1072996
Protective effects of mefunidone on ischemia-reperfusion injury/Folic acid-induced acute kidney injury.
Li J, Jiang Y, Dai Q, Yu Y, Lv X, Zhang Y, Liao X, Ao L, Hu G, Meng J, Peng Z, Tao L, Xie Y
Frontiers in pharmacology 2022;13:1043945
Frontiers in pharmacology 2022;13:1043945
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice.
Gu YH, Ren KW, Wang Y, Wang SH, Yu XH, Xu LW, Li HH, Bi HL
Frontiers in pharmacology 2022;13:1021361
Frontiers in pharmacology 2022;13:1021361
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation.
Li R, Li X, Zhao J, Meng F, Yao C, Bao E, Sun N, Chen X, Cheng W, Hua H, Li X, Wang B, Wang H, Pan X, You H, Yang J, Ikezoe T
Theranostics 2022;12(2):976-998
Theranostics 2022;12(2):976-998
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
Zhou B, Huang Y, Feng Q, Zhu H, Xu Z, Chen L, Peng X, Yang W, Xu D, Qiu Y
American journal of cancer research 2022;12(11):5205-5225
American journal of cancer research 2022;12(11):5205-5225
N(6)-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming.
Zhang K, Zhang T, Yang Y, Tu W, Huang H, Wang Y, Chen Y, Pan K, Chen Z
Theranostics 2022;12(10):4802-4817
Theranostics 2022;12(10):4802-4817
S645C Point Mutation Suppresses Degradation of EGFR to Promote Progression of Glioblastoma.
Huang W, Zou L, Hao Z, Wang B, Mao F, Duan Q, Guo D
Frontiers in oncology 2022;12:904383
Frontiers in oncology 2022;12:904383
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Liang S, Zhu C, Suo C, Wei H, Yu Y, Gu X, Chen L, Yuan M, Shen S, Li S, Sun L, Gao P
Frontiers in oncology 2022;12:857968
Frontiers in oncology 2022;12:857968
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Wang FF, Zhao PY, He XJ, Jiang K, Wang TS, Xiao JW, Sun DB, Guo DH
Frontiers in cellular and infection microbiology 2022;12:827750
Frontiers in cellular and infection microbiology 2022;12:827750
Olaparib Induces RPL5/RPL11-Dependent p53 Activation via Nucleolar Stress.
Han T, Tong J, Wang M, Gan Y, Gao B, Chen J, Liu Y, Hao Q, Zhou X
Frontiers in oncology 2022;12:821366
Frontiers in oncology 2022;12:821366
The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma.
Parkinson LM, Gillen SL, Woods LM, Chaytor L, Marcos D, Ali FR, Carroll JS, Philpott A
Frontiers in cell and developmental biology 2022;10:942579
Frontiers in cell and developmental biology 2022;10:942579
Maternal Factor Dppa3 Activates 2C-Like Genes and Depresses DNA Methylation in Mouse Embryonic Stem Cells.
Zhang C, Wen H, Liu S, Fu E, Yu L, Chen S, Han Q, Li Z, Liu N
Frontiers in cell and developmental biology 2022;10:882671
Frontiers in cell and developmental biology 2022;10:882671
Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination.
Yuan G, Yang S, Yang S
Genes & diseases 2022 Sep;9(5):1357-1367
Genes & diseases 2022 Sep;9(5):1357-1367
Transmembrane protein 121 as a novel inhibitor of cervical cancer metastasis.
Yang B, Cai Y, Zhu P, Jiang Z, Ao J, Zhang Q, Yuan W, Peng Z, Chen J, Wen Y, Chen Y, Wang Y, Shi Y, Zhu X, Ye X, Li F, Zhuang J, Wu X, Li Y, Fan X
Experimental and therapeutic medicine 2022 Sep;24(3):572
Experimental and therapeutic medicine 2022 Sep;24(3):572
Acetylation of fructose-bisphosphate aldolase-mediated glycolysis is essential for Bombyx mori nucleopolyhedrovirus infection.
Gao X, Xu S, Mo Y, Zhu Y, Chen X, Miao M, Quan Y, Yu W
Microbial pathogenesis 2022 Sep;170:105695
Microbial pathogenesis 2022 Sep;170:105695
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis.
Zhou Y, Lu Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113291
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113291
TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway.
Gu H, Zhu S, Peng C, Wei Z, Shen Y, Yuan C, Yang H, Cui H, Yang L
International journal of molecular sciences 2022 Sep 5;23(17)
International journal of molecular sciences 2022 Sep 5;23(17)
Multiple ciliary localization signals control INPP5E ciliary targeting.
Cilleros-Rodriguez D, Martin-Morales R, Barbeito P, Deb Roy A, Loukil A, Sierra-Rodero B, Herranz G, Pampliega O, Redrejo-Rodriguez M, Goetz SC, Izquierdo M, Inoue T, Garcia-Gonzalo FR
eLife 2022 Sep 5;11
eLife 2022 Sep 5;11
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.
Ma P, Wan LP, Li Y, He CH, Song NN, Zhao S, Wang H, Ding YQ, Mao B, Sheng N
Science advances 2022 Sep 30;8(39):eabq4736
Science advances 2022 Sep 30;8(39):eabq4736
Construction of Artificial Ovaries with Decellularized Porcine Scaffold and Its Elicited Immune Response after Xenotransplantation in Mice.
Wu T, Gao YY, Tang XN, Zhang JJ, Wang SX
Journal of functional biomaterials 2022 Sep 28;13(4)
Journal of functional biomaterials 2022 Sep 28;13(4)
Inhibiting ALK-TOPK signaling pathway promotes cell apoptosis of ALK-positive NSCLC.
Xiao J, Zhang L, Yi H, Zou L, Mo J, Xue F, Zheng J, Huang Y, Lu H, Wu H, Xue P, Zhang X, He L, Li Z, Pang S, Qiao G, Duan Q, Zhu F
Cell death & disease 2022 Sep 27;13(9):828
Cell death & disease 2022 Sep 27;13(9):828
Analysis of the Effects of Ninjin'yoeito on Physical Frailty in Mice.
Otsuka S, Fukumaru K, Tani A, Takada S, Kikuchi K, Norimatsu K, Matsuzaki R, Matsuoka T, Sakakima H, Omiya Y, Mizuno K, Matsubara Y, Maruyama I
International journal of molecular sciences 2022 Sep 23;23(19)
International journal of molecular sciences 2022 Sep 23;23(19)
Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer.
Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM
Cancer discovery 2022 Sep 2;12(9):2198-2219
Cancer discovery 2022 Sep 2;12(9):2198-2219
In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators.
Mareux E, Lapalus M, Ben Saad A, Zelli R, Lakli M, Riahi Y, Almes M, Banet M, Callebaut I, Decout JL, Falguières T, Jacquemin E, Gonzales E
International journal of molecular sciences 2022 Sep 15;23(18)
International journal of molecular sciences 2022 Sep 15;23(18)
PBAF chromatin remodeler complexes that mediate meiotic transitions in mouse.
de Castro RO, Previato de Almeida L, Carbajal A, Gryniuk I, Pezza RJ
Development (Cambridge, England) 2022 Sep 15;149(18)
Development (Cambridge, England) 2022 Sep 15;149(18)
Seneca Valley Virus Induces DHX30 Cleavage to Antagonize Its Antiviral Effects.
Wen W, Zheng Z, Wang H, Zhao Q, Yin M, Chen H, Li X, Qian P
Journal of virology 2022 Sep 14;96(17):e0112122
Journal of virology 2022 Sep 14;96(17):e0112122
An acetylated mannan isolated from Aloe vera induce colorectal cancer cells apoptosis via mitochondrial pathway.
Tong X, Lao C, Li D, Du J, Chen J, Xu W, Li L, Ye H, Guo X, Li J
Carbohydrate polymers 2022 Sep 1;291:119464
Carbohydrate polymers 2022 Sep 1;291:119464
Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication.
Xiao RW, Wang F, Wang TM, Zhang JB, Wu ZY, Deng CM, Liao Y, Zhou T, Yang DW, Dong SQ, Xue WQ, He YQ, Zheng XH, Li XZ, Zhang PF, Zhang SD, Hu YZ, Liu YY, Xia YF, Gao S, Mu JB, Feng L, Jia WH
EBioMedicine 2022 Oct;84:104267
EBioMedicine 2022 Oct;84:104267
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.
Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC
Nature metabolism 2022 Oct;4(10):1369-1401
Nature metabolism 2022 Oct;4(10):1369-1401
Human Cytomegalovirus UL24 and UL43 Cooperate to Modulate the Expression of Immunoregulatory UL16 Binding Protein 1.
Sleman S, Hao H, Najmuldeen H, Jalal P, Saeed N, Othman D, Qian Z
Viral immunology 2022 Oct;35(8):529-544
Viral immunology 2022 Oct;35(8):529-544
Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis.
Zhang HG, Wang B, Yang Y, Liu X, Wang J, Xin N, Li S, Miao Y, Wu Q, Guo T, Yuan Y, Zuo Y, Chen X, Ren T, Dong C, Wang J, Ruan H, Sun M, Xu X, Zheng H
Cell research 2022 Oct;32(10):897-913
Cell research 2022 Oct;32(10):897-913
Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription.
Xiong Y, Song X, Kudusi, Zu X, Chen M, He W, Qi L
Functional & integrative genomics 2022 Oct;22(5):937-950
Functional & integrative genomics 2022 Oct;22(5):937-950
Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function.
Wu MY, Zou WJ, Yu P, Yang Y, Li SJ, Liu Q, Xie J, Chen SQ, Lin WJ, Tang Y
Neural regeneration research 2022 Oct;17(10):2253-2259
Neural regeneration research 2022 Oct;17(10):2253-2259
DNA methylation status of DNAJA4 is essential for human erythropoiesis.
Zhang H, Xue F, Zhao H, Chen L, Wang T, Wu X
Epigenomics 2022 Oct;14(20):1249-1267
Epigenomics 2022 Oct;14(20):1249-1267
A novel Gboxin analog induces OXPHOS inhibition and mitochondrial dysfunction-mediated apoptosis in diffuse large B-cell lymphoma.
Yao S, Yin J, Liu W, Li Y, Huang J, Qi C, Hu Z, Tong Q, Gu L, Zhang Y
Bioorganic chemistry 2022 Oct;127:106019
Bioorganic chemistry 2022 Oct;127:106019
Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation.
Wang X, Duan C, Li Y, Lu H, Guo K, Ge X, Chen T, Shang Y, Liu H, Zhang D
International immunopharmacology 2022 Oct;111:109083
International immunopharmacology 2022 Oct;111:109083
D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia.
Florio E, Serra M, Lewis RG, Kramár E, Freidberg M, Wood M, Morelli M, Borrelli E
iScience 2022 Oct 21;25(10):105263
iScience 2022 Oct 21;25(10):105263
The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes.
Magusto J, Beaupère C, Afonso MB, Auclair M, Delaunay JL, Soret PA, Courtois G, Aït-Slimane T, Housset C, Jéru I, Fève B, Ratziu V, Rodrigues CMP, Gautheron J
iScience 2022 Oct 21;25(10):105166
iScience 2022 Oct 21;25(10):105166
Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12.
Wang Z, Wang S, Qin J, Zhang X, Lu G, Liu H, Guo H, Wu L, Shender VO, Shao C, Kong B, Liu Z
Nature communications 2022 Oct 21;13(1):6246
Nature communications 2022 Oct 21;13(1):6246
Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity.
Li Y, Huang J, Zhu J, Bao L, Wang H, Jiang Y, Tian K, Wang R, Zheng H, Duan W, Lai W, Yi X, Zhu Y, Guo T, Ji X
Molecular cell 2022 Oct 20;82(20):3943-3959.e11
Molecular cell 2022 Oct 20;82(20):3943-3959.e11
STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment.
Pu Z, Liu J, Liu Z, Peng F, Zhu Y, Wang X, He J, Yi P, Hu X, Fan X, Chen J
Cancer cell international 2022 Oct 12;22(1):314
Cancer cell international 2022 Oct 12;22(1):314
PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK.
Zi J, Xu J, Luo J, Yang X, Zhen Z, Li X, Hu D, Guo Y, Guo H, Ding X, Zhang L
Cells 2022 Oct 11;11(20)
Cells 2022 Oct 11;11(20)
Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model.
Pei Z, Qin Y, Fu X, Yang F, Huo F, Liang X, Wang S, Cui H, Lin P, Zhou G, Yan J, Wu J, Chen ZN, Zhu P
Redox biology 2022 Nov;57:102509
Redox biology 2022 Nov;57:102509
Hypotonic induction of aquaporin5 expression in rat astrocytes through p38 MAPK pathway.
Yi Y, Qiu G, Liu H, Gao F, Liu X, Chen Y, Yang M
Anatomia, histologia, embryologia 2022 Nov;51(6):769-780
Anatomia, histologia, embryologia 2022 Nov;51(6):769-780
E3 ubiquitin ligase MID1 ubiquitinates and degrades type-I interferon receptor 2.
Chen X, Zhao Q, Xu Y, Wu Q, Zhang R, Du Q, Miao Y, Zuo Y, Zhang HG, Huang F, Ren T, He J, Qiao C, Li Y, Li S, Xu Y, Wu D, Yu Z, Lv H, Wang J, Zheng H, Yuan Y
Immunology 2022 Nov;167(3):398-412
Immunology 2022 Nov;167(3):398-412
HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
Zhang G, Tan R, Wan S, Yang R, Hu X, Zhao E, Ding X, Zhang J, Li B, Liang P, Cui H
British journal of cancer 2022 Nov;127(11):1925-1938
British journal of cancer 2022 Nov;127(11):1925-1938
Menthone inhibits type-I interferon signaling by promoting Tyk2 ubiquitination to relieve local inflammation of rheumatoid arthritis.
Chen X, Wu Q, Cao X, Yang Y, Gong Z, Ren T, Du Q, Yuan Y, Zuo Y, Miao Y, He J, Qiao C, Zheng Z, Zhang T, Xu Y, Wu D, Wang Q, Huang L, Xie Z, Lv H, Wang J, Gong F, Liu Z, Wen C, Zheng H
International immunopharmacology 2022 Nov;112:109228
International immunopharmacology 2022 Nov;112:109228
UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum.
Song P, Yang W, Lou KF, Dong H, Zhang H, Wang B, Chen D
EMBO reports 2022 Nov 7;23(11):e55099
EMBO reports 2022 Nov 7;23(11):e55099
Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export.
Nakashima N, Nakashima A, Nakashima K, Takano M
Molecular brain 2022 Nov 4;15(1):89
Molecular brain 2022 Nov 4;15(1):89
Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice.
Wang X, Li Y, Qiang G, Wang K, Dai J, McCann M, Munoz MD, Gil V, Yu Y, Li S, Yang Z, Xu S, Cordoba-Chacon J, De Jesus DF, Sun B, Chen K, Wang Y, Liu X, Miao Q, Zhou L, Hu R, Ding Q, Kulkarni RN, Gao D, Blüher M, Liew CW
Nature communications 2022 Nov 28;13(1):7323
Nature communications 2022 Nov 28;13(1):7323
BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.
Liu C, Yu J, Liu B, Liu M, Song G, Zhu L, Peng B
BMC oral health 2022 Nov 24;22(1):536
BMC oral health 2022 Nov 24;22(1):536
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
Cao Y, Zhang M, Li Y, Lu J, Zhou W, Li X, Shi H, Xu B, Li S
International journal of molecular sciences 2022 Nov 22;23(23)
International journal of molecular sciences 2022 Nov 22;23(23)
Naringenin Promotes Myotube Formation and Maturation for Cultured Meat Production.
Yan Q, Fei Z, Li M, Zhou J, Du G, Guan X
Foods (Basel, Switzerland) 2022 Nov 22;11(23)
Foods (Basel, Switzerland) 2022 Nov 22;11(23)
Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.
Zhou J, Zeng L, Zhang Y, Wang M, Li Y, Jia Y, Wu L, Su P
The Science of the total environment 2022 Nov 15;847:157500
The Science of the total environment 2022 Nov 15;847:157500
Integrative and Comprehensive Pan-Cancer Analysis of Lymphocyte-Specific Protein Tyrosine Kinase in Human Tumors.
Han M, Li Y, Guo Y, Zhu W, Jiang J
International journal of molecular sciences 2022 Nov 13;23(22)
International journal of molecular sciences 2022 Nov 13;23(22)
METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability.
Chen L, Zhang C, Ma W, Huang J, Zhao Y, Liu H
Nucleic acids research 2022 Nov 11;50(20):11619-11634
Nucleic acids research 2022 Nov 11;50(20):11619-11634
KIF17 maintains the epithelial phenotype of breast cancer cells and curbs tumour metastasis.
Li T, Zhai D, Zhang M, Ye R, Kuang X, Shao N, Bi J, Lin Y
Cancer letters 2022 Nov 1;548:215904
Cancer letters 2022 Nov 1;548:215904
Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation.
Wang YF, Chang YY, Zhang XM, Gao MT, Zhang QL, Li X, Zhang L, Yao WF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154020
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154020
D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes.
Ma J, Zhang X, Song Y, Qin Y, Tan Y, Zheng L, Cheng B, Xi X
Journal of physiology and biochemistry 2022 May;78(2):355-363
Journal of physiology and biochemistry 2022 May;78(2):355-363
Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics.
Lin JR, Cheng JF, Liu YT, Hsu TR, Lin KM, Chen C, Lin CL, Tsai MH, Tsai JW
Epilepsia 2022 May;63(5):1253-1265
Epilepsia 2022 May;63(5):1253-1265
MEIG1 determines the manchette localization of IFT20 and IFT88, two intraflagellar transport components in male germ cells.
Yap YT, Shi L, Zhang D, Huang Q, Siddika F, Wang Z, Li W, Zhang Z
Developmental biology 2022 May;485:50-60
Developmental biology 2022 May;485:50-60
A comparative study of Mesenchymal Stem Cells transplantation approach to antagonize age-associated ovarian hypofunction with consideration of safety and efficiency.
Wang L, Mei Q, Xie Q, Li H, Su P, Zhang L, Li K, Ma D, Chen G, Li J, Xiang W
Journal of advanced research 2022 May;38:245-259
Journal of advanced research 2022 May;38:245-259
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair.
Sakasai R, Wakasugi M, Matsui T, Sunatani Y, Saijo M, Matsunaga T, Iwabuchi K
DNA repair 2022 May;113:103318
DNA repair 2022 May;113:103318
Deletion of the miR-144/451 cluster aggravates lethal sepsis-induced lung epithelial oxidative stress and apoptosis.
Wu F, Yuan X, Liu W, Meng L, Li X, Gao X, Zhou S, Fang L, Yu D
Annals of translational medicine 2022 May;10(10):538
Annals of translational medicine 2022 May;10(10):538
A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus.
Kanemoto Y, Nishimura K, Hayakawa A, Sawada T, Amano R, Mori J, Kurokawa T, Murakami Y, Kato S
Bioscience reports 2022 May 27;42(5)
Bioscience reports 2022 May 27;42(5)
Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma.
Zheng ZY, Chu MY, Lin W, Zheng YQ, Xu XE, Chen Y, Liao LD, Wu ZY, Wang SH, Li EM, Xu LY
Cell death & disease 2022 May 25;13(5):496
Cell death & disease 2022 May 25;13(5):496
Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.
Yuan K, Li Z, Kuang W, Wang X, Ji M, Chen W, Ding J, Li J, Min W, Sun C, Ye X, Lu M, Wang L, Ge H, Jiang Y, Hao H, Xiao Y, Yang P
Nature communications 2022 May 25;13(1):2903
Nature communications 2022 May 25;13(1):2903
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.
Zhao C, Yu H, Fan X, Niu W, Fan J, Sun S, Gong M, Zhao B, Fang Z, Chen X
Oncogenesis 2022 May 23;11(1):28
Oncogenesis 2022 May 23;11(1):28
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Zhou T, Chen T, Lai B, Zhang W, Luo X, Xia D, Fu W, Xu J
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.
Singh A, D'Amico D, Andreux PA, Fouassier AM, Blanco-Bose W, Evans M, Aebischer P, Auwerx J, Rinsch C
Cell reports. Medicine 2022 May 17;3(5):100633
Cell reports. Medicine 2022 May 17;3(5):100633
Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment.
Mei Z, Yang T, Liu Y, Gao Y, Hou Z, Zhuang Q, He D, Zhang X, Tan Q, Zhu X, Qin Y, Chen X, Xu C, Bian C, Wang X, Wang C, Wu D, Huang S, Li Z
Cell reports. Medicine 2022 May 17;3(5):100608
Cell reports. Medicine 2022 May 17;3(5):100608
MRNIP condensates promote DNA double-strand break sensing and end resection.
Wang YL, Zhao WW, Bai SM, Feng LL, Bie SY, Gong L, Wang F, Wei MB, Feng WX, Pang XL, Qin CL, Yin XK, Wang YN, Zhou W, Wahl DR, Liu Q, Chen M, Hung MC, Wan XB
Nature communications 2022 May 12;13(1):2638
Nature communications 2022 May 12;13(1):2638
Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.
Lyu F, Li Y, Yan Z, He Q, Cheng L, Zhang P, Liu B, Liu C, Song Y, Xing Y
Journal of translational medicine 2022 May 10;20(1):202
Journal of translational medicine 2022 May 10;20(1):202
Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia.
Wu M, Liao M, Huang R, Chen C, Tian T, Wang H, Li J, Li J, Sun Y, Wu C, Li Q, Xiao X
Genes & diseases 2022 Mar;9(2):401-414
Genes & diseases 2022 Mar;9(2):401-414
miR-1290 promotes IL-8-mediated vascular endothelial cell adhesion by targeting GSK-3β.
Xu H, Cui Y, Liu X, Zheng X, Liu J, Hu X, Gao F, Hu X, Li M, Wei X, Gao Y, Zhao Y
Molecular biology reports 2022 Mar;49(3):1871-1882
Molecular biology reports 2022 Mar;49(3):1871-1882
iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.
Zhao D, Zheng S, Wang X, Liu H, Zhao K, Li L, Hu Y
Oncogene 2022 Mar;41(13):1944-1958
Oncogene 2022 Mar;41(13):1944-1958
Map, but not EspF, induces breast epithelial cell apoptosis through ERK/DRP-1 pathway.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Veterinary microbiology 2022 Mar;266:109367
Veterinary microbiology 2022 Mar;266:109367
LINC00244 suppresses cell growth and metastasis in hepatocellular carcinoma by downregulating programmed cell death ligand 1.
Sun Z, Xue C, Li J, Zhao H, Du Y, Du N
Bioengineered 2022 Mar;13(3):7635-7647
Bioengineered 2022 Mar;13(3):7635-7647
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells.
Zeng Q, Jin F, Qian H, Chen H, Wang Y, Zhang D, Wei Y, Chen T, Guo B, Chai C
Carcinogenesis 2022 Mar 24;43(2):150-159
Carcinogenesis 2022 Mar 24;43(2):150-159
Neddylation is essential for β-catenin degradation in Wnt signaling pathway.
Wang B, Wang T, Zhu H, Yan R, Li X, Zhang C, Tao W, Ke X, Hao P, Qu Y
Cell reports 2022 Mar 22;38(12):110538
Cell reports 2022 Mar 22;38(12):110538
The identification of alternative oxidase in intermediate host snails of Schistosoma and its potential role in protecting Oncomelania hupensis against niclosamide-induced stress.
Jiang N, Li SZ, Zhang YW, Habib MR, Xiong T, Xu S, Dong H, Zhao QP
Parasites & vectors 2022 Mar 21;15(1):97
Parasites & vectors 2022 Mar 21;15(1):97
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H
Molecular cell 2022 Mar 17;82(6):1156-1168.e7
Molecular cell 2022 Mar 17;82(6):1156-1168.e7
RAD51 is essential for spermatogenesis and male fertility in mice.
Qin J, Huang T, Wang J, Xu L, Dang Q, Xu X, Liu H, Liu Z, Shao C, Zhang X
Cell death discovery 2022 Mar 15;8(1):118
Cell death discovery 2022 Mar 15;8(1):118
C3/C3aR inhibition alleviates GMH-IVH-induced hydrocephalus by preventing microglia-astrocyte interactions in neonatal rats.
Tang J, Jila S, Luo T, Zhang B, Miao H, Feng H, Chen Z, Zhu G
Neuropharmacology 2022 Mar 1;205:108927
Neuropharmacology 2022 Mar 1;205:108927
ARID3A promotes the chemosensitivity of colon cancer by inhibiting AKR1C3.
Li Y, Tang J, Li J, Du Y, Bai F, Yang L, Li X, Jin X, Wang T
Cell biology international 2022 Jun;46(6):965-975
Cell biology international 2022 Jun;46(6):965-975
MiR-15p-5p Mediates the Coordination of ICAM-1 and FAK to Promote Endothelial Cell Proliferation and Migration.
Gu W, Zhang L, Zhang X, Wang B, Shi X, Hu K, Ye Y, Liu G
Inflammation 2022 Jun;45(3):1402-1417
Inflammation 2022 Jun;45(3):1402-1417
Resveratrol alleviates aluminum-induced intestinal barrier dysfunction in mice.
Hao W, Zhu X, Liu Z, Song Y, Wu S, Lu X, Yang J, Jin C
Environmental toxicology 2022 Jun;37(6):1373-1381
Environmental toxicology 2022 Jun;37(6):1373-1381
Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
Li SN, Yu YL, Wang BY, Qiao SY, Hu MM, Wang H, Fu CN, Dong B
Human gene therapy 2022 Jun;33(11-12):598-613
Human gene therapy 2022 Jun;33(11-12):598-613
Cell cycle arrest induced by trichoplein depletion is independent of cilia assembly.
Huang M, Kong X, Tang Z, Lin Z, He R, Cao M, Zhang X
Journal of cellular physiology 2022 Jun;237(6):2703-2712
Journal of cellular physiology 2022 Jun;237(6):2703-2712
Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer.
Zhang S, Chen X, Wu C, Xu H, Xie X, Feng M, Hu S, Bai H, Gao F, Tong L, Ding J, Liu H, Xie Z, Wang J
Journal of medicinal chemistry 2022 Jun 9;65(11):7697-7716
Journal of medicinal chemistry 2022 Jun 9;65(11):7697-7716
Insulin alleviates LPS-induced ARDS via inhibiting CUL4B-mediated proteasomal degradation and restoring expression level of Na,K-ATPase α1 subunit through elevating HCF-1.
Huang XT, Zheng Y, Long G, Peng WT, Wan QQ
Biochemical and biophysical research communications 2022 Jun 30;611:60-67
Biochemical and biophysical research communications 2022 Jun 30;611:60-67
MicroRNA-223-3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU.1).
Zhao S, Tan Y, Qin J, Xu H, Liu L, Wan H, Zhang C, Fan W, Qu S
Toxicology 2022 Jun 30;476:153252
Toxicology 2022 Jun 30;476:153252
Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism.
Chen L, Song Y, Hou T, Li X, Cheng L, Li Y, Xing Y
Journal of experimental & clinical cancer research : CR 2022 Jun 3;41(1):194
Journal of experimental & clinical cancer research : CR 2022 Jun 3;41(1):194
Enhanced autophagy promotes radiosensitivity by mediating Sirt1 downregulation in RM-1 prostate cancer cells.
Wang KX, Yan C, Yang X, Zhu PY, Cui WW, Ye C, Hu K, Lan T, Huang LY, Wang W, Ma P, Qi SH, Gu B, Luo L
Biochemical and biophysical research communications 2022 Jun 18;609:84-92
Biochemical and biophysical research communications 2022 Jun 18;609:84-92
Protocol for isolation and proteostatic analysis of sub-populations of spermatogenic cells in mouse.
Zou Q, Yang L, Qi H
STAR protocols 2022 Jun 17;3(2):101398
STAR protocols 2022 Jun 17;3(2):101398
Isolation of five different primary cell types from a single sample of human skin.
Kabacik S, Lowe D, Cohen H, Felton S, Spitzer J, Raj K
STAR protocols 2022 Jun 17;3(2):101378
STAR protocols 2022 Jun 17;3(2):101378
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Lee JE, Kim N, Jung M, Mun JY, Yoo JY
Autophagy 2022 Jul;18(7):1613-1628
Autophagy 2022 Jul;18(7):1613-1628
Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding.
Wang L, Wen X, Wang Z, Lin Z, Li C, Zhou H, Yu H, Li Y, Cheng Y, Chen Y, Lou G, Pan J, Cao M
Nature communications 2022 Jul 9;13(1):3997
Nature communications 2022 Jul 9;13(1):3997
H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis.
Li Z, Zhang X, Xie S, Liu X, Fei C, Huang X, Tang Y, Zhou LQ
Nucleic acids research 2022 Jul 8;50(12):6786-6800
Nucleic acids research 2022 Jul 8;50(12):6786-6800
Antagonistic action of a synthetic androgen ligand mediated by chromatin remodeling in a human prostate cancer cell line.
Sawada T, Kanemoto Y, Amano R, Hayakawa A, Kurokawa T, Mori J, Kato S
Biochemical and biophysical research communications 2022 Jul 5;612:110-118
Biochemical and biophysical research communications 2022 Jul 5;612:110-118
Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1.
Vabret N, Najburg V, Solovyov A, Gopal R, McClain C, Šulc P, Balan S, Rahou Y, Beauclair G, Chazal M, Varet H, Legendre R, Sismeiro O, Sanchez David RY, Chauveau L, Jouvenet N, Markowitz M, van der Werf S, Schwartz O, Tangy F, Bhardwaj N, Greenbaum BD, Komarova AV
iScience 2022 Jul 15;25(7):104599
iScience 2022 Jul 15;25(7):104599
Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling.
Ribeiro LW, Pietri M, Ardila-Osorio H, Baudry A, Boudet-Devaud F, Bizingre C, Arellano-Anaya ZE, Haeberlé AM, Gadot N, Boland S, Devineau S, Bailly Y, Kellermann O, Bencsik A, Schneider B
Particle and fibre toxicology 2022 Jul 15;19(1):48
Particle and fibre toxicology 2022 Jul 15;19(1):48
ER proteins decipher the tubulin code to regulate organelle distribution.
Zheng P, Obara CJ, Szczesna E, Nixon-Abell J, Mahalingan KK, Roll-Mecak A, Lippincott-Schwartz J, Blackstone C
Nature 2022 Jan;601(7891):132-138
Nature 2022 Jan;601(7891):132-138
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease.
Yin F, Zheng PQ, Zhao LQ, Wang YZ, Miao NJ, Zhou ZL, Cheng Q, Chen PP, Xie HY, Li JY, Ni JY, Zhou L, Zhang W, Wang XX, Liu J, Lu LM
Acta pharmacologica Sinica 2022 Jan;43(1):86-95
Acta pharmacologica Sinica 2022 Jan;43(1):86-95
Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress.
Hao X, Bu W, Lv G, Xu L, Hou D, Wang J, Liu X, Yang T, Zhang X, Liu Q, Gong Y, Shao C
Oncogene 2022 Jan;41(3):427-443
Oncogene 2022 Jan;41(3):427-443
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
Liu Z, Cai Y, Deng M, Li D, Leng Q, Shi L, Tang Y, Wang F, Wan Y
Cell and tissue research 2022 Jan;387(1):131-142
Cell and tissue research 2022 Jan;387(1):131-142
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites.
Tang P, Yang Y, Li G, Huang L, Wen M, Ruan W, Guo X, Zhang C, Zuo X, Luo D, Xu Y, Fu XD, Zhou Y
Nature structural & molecular biology 2022 Jan;29(1):21-31
Nature structural & molecular biology 2022 Jan;29(1):21-31
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence.
Li X, Li X, Xie C, Cai S, Li M, Jin H, Wu S, Cui J, Liu H, Zhao Y
Protein & cell 2022 Jan;13(1):47-64
Protein & cell 2022 Jan;13(1):47-64
Annexin A1 promotes the progression of bladder cancer via regulating EGFR signaling pathway.
Li P, Li L, Li Z, Wang S, Li R, Zhao W, Feng Y, Huang S, Li L, Qiu H, Xia S
Cancer cell international 2022 Jan 6;22(1):7
Cancer cell international 2022 Jan 6;22(1):7
High salt activates p97 to reduce host antiviral immunity by restricting Viperin induction.
Yuan Y, Miao Y, Ren T, Huang F, Qian L, Chen X, Zuo Y, Zhang HG, He J, Qiao C, Du Q, Wu Q, Zhang W, Zhu C, Xu Y, Wu D, Shi W, Jiang J, Xu G, Zheng H
EMBO reports 2022 Jan 5;23(1):e53466
EMBO reports 2022 Jan 5;23(1):e53466
DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway.
Liu L, Dai X, Yin S, Liu P, Hill EG, Wei W, Gan W
Science signaling 2022 Jan 4;15(715):eabh2290
Science signaling 2022 Jan 4;15(715):eabh2290
Inhibiting STAT5 significantly attenuated Ang II-induced cardiac dysfunction and inflammation.
Jin G, Wang L, Ma J
European journal of pharmacology 2022 Jan 15;915:174689
European journal of pharmacology 2022 Jan 15;915:174689
Aging is associated with increased brain iron through cortex-derived hepcidin expression.
Sato T, Shapiro JS, Chang HC, Miller RA, Ardehali H
eLife 2022 Jan 11;11
eLife 2022 Jan 11;11
Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
Xie Z, Hou L, Shen S, Wu Y, Wang J, Jie Z, Zhao X, Li X, Zhang X, Chen J, Xu W, Ning L, Ma Q, Wang S, Wang H, Yuan P, Fang X, Qin A, Fan S
Nature communications 2022 Jan 10;13(1):50
Nature communications 2022 Jan 10;13(1):50
Ajuba functions as a co-activator of C/EBPβ to induce expression of PPARγ and C/EBPα during adipogenesis.
Yan H, Li Q, Li M, Zou X, Bai N, Yu Z, Zhang J, Zhang D, Zhang Q, Wang J, Jia H, Wu Y, Hou Z
Molecular and cellular endocrinology 2022 Jan 1;539:111485
Molecular and cellular endocrinology 2022 Jan 1;539:111485
Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.
Bai Z, Zhou Y, Ye X, Li Y, Peng Y, Guan Q, Zhang W, Ma L
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119174
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119174
Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4.
Sun X, Xiao H, Li S, Chen R, Lin Z, Yang Y, Chen Z, Deng L, Huang H
Pharmacological research 2022 Feb;176:106084
Pharmacological research 2022 Feb;176:106084
4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects.
Birus R, El-Awaad E, Ballentin L, Alchab F, Aichele D, Ettouati L, Götz C, Le Borgne M, Jose J
FEBS open bio 2022 Feb;12(2):394-411
FEBS open bio 2022 Feb;12(2):394-411
Alpha-synuclein/MPP(+) mediated activation of NLRP3 inflammasome through microtubule-driven mitochondrial perinuclear transport.
Yang X, Ma H, Yv Q, Ye F, He Z, Chen S, Keram A, Li W, Zhu M
Biochemical and biophysical research communications 2022 Feb 26;594:161-167
Biochemical and biophysical research communications 2022 Feb 26;594:161-167
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Wang Q, Chen W, Zhang B, Gao Z, Zhang Q, Deng H, Han L, Shen XL
Chemico-biological interactions 2022 Feb 25;354:109844
Chemico-biological interactions 2022 Feb 25;354:109844
Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1.
Lei C, Li M, Qiu Y, Xie Y, Hao Z, Yin X, Zhang Z, Su H, Yang L, Lin J, Hammes HP, Zhang C
Cell death & disease 2022 Feb 25;13(2):184
Cell death & disease 2022 Feb 25;13(2):184
HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.
Wu AC, Yang WB, Chang KY, Lee JS, Liou JP, Su RY, Cheng SM, Hwang DY, Kikkawa U, Hsu TI, Wang CY, Chang WC, Chen PY, Chuang JY
Journal of experimental & clinical cancer research : CR 2022 Feb 2;41(1):47
Journal of experimental & clinical cancer research : CR 2022 Feb 2;41(1):47
Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription.
Yang W, Li J, Zhang M, Yu H, Zhuang Y, Zhao L, Ren L, Gong J, Bi H, Zeng L, Xue Y, Yang J, Zhao Y, Wang S, Gao S, Fu Z, Li D, Zhang J, Wang T, Shan M, Tang B, Li X
Journal of experimental & clinical cancer research : CR 2022 Feb 18;41(1):67
Journal of experimental & clinical cancer research : CR 2022 Feb 18;41(1):67
Progerin-expressing endothelial cells are unable to adapt to shear stress.
Danielsson BE, Peters HC, Bathula K, Spear LM, Noll NA, Dahl KN, Conway DE
Biophysical journal 2022 Feb 15;121(4):620-628
Biophysical journal 2022 Feb 15;121(4):620-628
ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation.
Azzarelli R, McNally A, Dell'Amico C, Onorati M, Simons B, Philpott A
Scientific reports 2022 Feb 11;12(1):2341
Scientific reports 2022 Feb 11;12(1):2341
Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly.
Cao Y, Zhu X, Zhen P, Tian Y, Ji D, Xue K, Yan W, Chai J, Liu H, Wang W
Cell proliferation 2022 Dec;55(12):e13322
Cell proliferation 2022 Dec;55(12):e13322
HIF-1α upregulation exerts the antagonistic effect against angiogenesis inhibition in manganese deficiency-induced tibial dyschondroplasia of broiler chicks.
Lu L, Jin C, Dong PF, Wang ZY
Veterinary research communications 2022 Dec;46(4):1023-1032
Veterinary research communications 2022 Dec;46(4):1023-1032
6-O-desulfated heparin attenuates myocardial ischemia/reperfusion injury in mice through the regulation of miR-199a-5p/klotho axis.
Wang Y, Li T, Li N, Huang C, Xiong X, Xie X, Wu M, Wang L, Jiang J
Glycoconjugate journal 2022 Dec;39(6):747-758
Glycoconjugate journal 2022 Dec;39(6):747-758
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.
Hu CL, Chen BY, Li Z, Yang T, Xu CH, Yang R, Yu PC, Zhao J, Liu T, Liu N, Shan B, Zhang Q, Song J, Fei MY, Zong LJ, Zhang JY, Wu JC, Chen SB, Wang Y, Chang B, Hou D, Liu P, Jiang Y, Li X, Chen X, Deng CH, Ren YY, Wang R, Jin J, Xue K, Zhang Y, Du M, Shi J, Wu LY, Chang CK, Shen S, Chen Z, Chen SJ, Liu X, Sun XJ, Zheng M, Wang L
Cell research 2022 Dec;32(12):1105-1123
Cell research 2022 Dec;32(12):1105-1123
The ubiquitination of CKIP-1 mediated by Src aggravates diabetic renal fibrosis (original article).
Yang Y, Xiao H, Lin Z, Chen R, Li S, Li C, Sun X, Hei Z, Gong W, Huang H
Biochemical pharmacology 2022 Dec;206:115339
Biochemical pharmacology 2022 Dec;206:115339
Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-κB pathway and activating Keap1-NRF2 signaling in macrophages.
He J, Liu L, Liu X, Chen H, Liu K, Huang N, Wang Y
International immunopharmacology 2022 Dec;113(Pt A):109404
International immunopharmacology 2022 Dec;113(Pt A):109404
Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway.
Liu W, Liu M, Xiong H, Xia L, Yang Q, Chen M, Cai Y, Li S
International immunopharmacology 2022 Dec;113(Pt A):109392
International immunopharmacology 2022 Dec;113(Pt A):109392
Mefunidone ameliorates lipopolysaccharide-induced acute lung injury through inhibiting MAPK signaling pathway and enhancing Nrf2 pathway.
Yao TT, Zhang Y, He RL, Lv X, He YJ, Li MY, Han YY, Long LZ, Jiang GL, Cheng XY, Hu GY, Li QB, Tao LJ, Meng J
International immunopharmacology 2022 Dec;113(Pt A):109263
International immunopharmacology 2022 Dec;113(Pt A):109263
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner.
Zhou YQ, Wang K, Wang XY, Cui HY, Zhao Y, Zhu P, Chen ZN
Emerging microbes & infections 2022 Dec;11(1):1135-1144
Emerging microbes & infections 2022 Dec;11(1):1135-1144
Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair.
Liu L, Lin B, Yin S, Ball LE, Delaney JR, Long DT, Gan W
Science advances 2022 Dec 9;8(49):eadd8928
Science advances 2022 Dec 9;8(49):eadd8928
The central scaffold protein CEP350 coordinates centriole length, stability, and maturation.
Karasu OR, Neuner A, Atorino ES, Pereira G, Schiebel E
The Journal of cell biology 2022 Dec 5;221(12)
The Journal of cell biology 2022 Dec 5;221(12)
Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-κB signaling pathway.
Xiong H, Ye J, Xie K, Hu W, Xu N, Yang H
Lipids in health and disease 2022 Dec 29;21(1):147
Lipids in health and disease 2022 Dec 29;21(1):147
Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence.
Li C, Liu Z, Chen M, Zhang L, Shi R, Zhong H
Biology 2022 Dec 26;12(1)
Biology 2022 Dec 26;12(1)
The deubiquitinase USP10 protects pancreatic cancer cells from endoplasmic reticulum stress.
Bhattacharya U, Thavathiru E, Neizer-Ashun F, Xu C, Gatalica Z, Dwivedi SKD, Dey A, Mukherjee P, Bhattacharya R
NPJ precision oncology 2022 Dec 21;6(1):93
NPJ precision oncology 2022 Dec 21;6(1):93
Trehalose prevents glyphosate-induced testicular damage in roosters via its antioxidative properties.
Chen K, Liu JB, Tie CZ, Wang L
Research in veterinary science 2022 Dec 20;152:314-322
Research in veterinary science 2022 Dec 20;152:314-322
Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis.
Wang Z, Sun Y, Lou F, Bai J, Zhou H, Cai X, Sun L, Yin Q, Tang S, Wu Y, Fan L, Xu Z, Wang H, Hu X, Wang H
Nature communications 2022 Dec 19;13(1):7815
Nature communications 2022 Dec 19;13(1):7815
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha.
Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH, Tan M, Zhao B
Molecular cell 2022 Dec 15;82(24):4700-4711.e12
Molecular cell 2022 Dec 15;82(24):4700-4711.e12
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway.
Yang C, Kang F, Huang X, Zhang W, Wang S, Han M, Zhang Z, Li J
Neuropharmacology 2022 Dec 1;220:109254
Neuropharmacology 2022 Dec 1;220:109254
Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma.
Li X, Chen Q, Liu J, Lai S, Zhang M, Zhen T, Hu H, Gao X, Wong AST, Zeng JZ
Cells 2022 Dec 1;11(23)
Cells 2022 Dec 1;11(23)
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351
Redox biology 2022 Aug;54:102351
Metformin alleviates the cognitive impairment caused by aluminum by improving energy metabolism disorders in mice.
Song Y, Liu Z, Zhu X, Hao C, Hao W, Wu S, Yang J, Lu X, Jin C
Biochemical pharmacology 2022 Aug;202:115140
Biochemical pharmacology 2022 Aug;202:115140
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1.
Zhang S, Wang J, Wang L, Aliyari S, Cheng G
Cellular & molecular immunology 2022 Aug;19(8):872-882
Cellular & molecular immunology 2022 Aug;19(8):872-882
Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.
Shao T, Ke H, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y, Zhao S
Autophagy 2022 Aug;18(8):1864-1878
Autophagy 2022 Aug;18(8):1864-1878
The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy.
Cheng G, Zhang S, Lv M, Qi C, Fan R, Guo X, Liu J, Zhao X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154212
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154212
Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers.
Bai L, Tu WY, Xiao Y, Zhang K, Shen C
Cell & bioscience 2022 Aug 30;12(1):140
Cell & bioscience 2022 Aug 30;12(1):140
Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes.
Lan T, Zhang K, Lin F, He Q, Wu S, Xu Z, Zhang Y, Quan F
International journal of molecular sciences 2022 Aug 3;23(15)
International journal of molecular sciences 2022 Aug 3;23(15)
Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma.
Zrimšek M, Kuchaříková H, Draganić K, Dobrovolná P, Heiss Spornberger V, Winkelmayer L, Hassler MR, Lochmanová G, Zdráhal Z, Egger G
Cells 2022 Aug 2;11(15)
Cells 2022 Aug 2;11(15)
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Liang C, Zhang S, Robinson D, Ploeg MV, Wilson R, Nah J, Taylor D, Beh S, Lim R, Sun L, Muoio DM, Stroud DA, Ho L
Cell reports 2022 Aug 16;40(7):111204
Cell reports 2022 Aug 16;40(7):111204
DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0.
Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Zeng GD, Wang F, Feng WX, Zheng J, Wang YN, Zeng B, Liu Q, Hung MC, Wan XB
Cell death & disease 2022 Aug 16;13(8):709
Cell death & disease 2022 Aug 16;13(8):709
Damage of uremic myocardium by p-cresyl sulfate and the ameliorative effect of Klotho by regulating SIRT6 ubiquitination.
Chen C, Xie C, Xiong Y, Wu H, Wu L, Zhu J, Xing C, Mao H
Toxicology letters 2022 Aug 15;367:19-31
Toxicology letters 2022 Aug 15;367:19-31
A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology.
Zhou J, Duan M, Wang X, Zhang F, Zhou H, Ma T, Yin Q, Zhang J, Tian F, Wang G, Yang C
Nature cell biology 2022 Apr;24(4):526-537
Nature cell biology 2022 Apr;24(4):526-537
Recycling of autophagosomal components from autolysosomes by the recycler complex.
Zhou C, Wu Z, Du W, Que H, Wang Y, Ouyang Q, Jian F, Yuan W, Zhao Y, Tian R, Li Y, Chen Y, Gao S, Wong CCL, Rong Y
Nature cell biology 2022 Apr;24(4):497-512
Nature cell biology 2022 Apr;24(4):497-512
Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation.
Xue J, Liao Q, Luo M, Hua C, Zhao J, Yu G, Chen X, Li X, Zhang X, Ran R, Lu F, Wang Y, Qiao L
Open biology 2022 Apr;12(4):210310
Open biology 2022 Apr;12(4):210310
LATS1 is a central signal transmitter for achieving full type-I interferon activity.
Zuo Y, He J, Liu S, Xu Y, Liu J, Qiao C, Zang L, Sun W, Yuan Y, Zhang H, Chen X, Jin L, Miao Y, Huang F, Ren T, Wang J, Qian F, Zhu C, Zhang W, Liu Y, Xu G, Ma F, Zheng H
Science advances 2022 Apr 8;8(14):eabj3887
Science advances 2022 Apr 8;8(14):eabj3887
Hexokinase 1 cellular localization regulates the metabolic fate of glucose.
De Jesus A, Keyhani-Nejad F, Pusec CM, Goodman L, Geier JA, Stoolman JS, Stanczyk PJ, Nguyen T, Xu K, Suresh KV, Chen Y, Rodriguez AE, Shapiro JS, Chang HC, Chen C, Shah KP, Ben-Sahra I, Layden BT, Chandel NS, Weinberg SE, Ardehali H
Molecular cell 2022 Apr 7;82(7):1261-1277.e9
Molecular cell 2022 Apr 7;82(7):1261-1277.e9
DELE1 tracks perturbed protein import and processing in human mitochondria.
Fessler E, Krumwiede L, Jae LT
Nature communications 2022 Apr 6;13(1):1853
Nature communications 2022 Apr 6;13(1):1853
Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression.
Li Y, Yang C, Wang H, Zhao L, Kong Q, Cang Y, Zhao S, Lv L, Li Y, Mao B, Ma P
Journal of molecular cell biology 2022 Apr 5;14(1)
Journal of molecular cell biology 2022 Apr 5;14(1)
Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXRα/PCSK9 pathway.
Zhu W, Ding C, Huang P, Ran J, Lian P, Tang Y, Dai W, Huang X
Scientific reports 2022 Apr 4;12(1):5639
Scientific reports 2022 Apr 4;12(1):5639
Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors.
Kim SJ, Woo Y, Kim HJ, Goo BS, Nhung TTM, Lee SA, Suh BK, Mun DJ, Kim JH, Park SK
eLife 2022 Apr 25;11
eLife 2022 Apr 25;11
Inhibition of CK2 Reduces NG2 Expression in Juvenile Angiofibroma.
Boewe AS, Wemmert S, Kulas P, Schick B, Götz C, Wrublewsky S, Montenarh M, Menger MD, Laschke MW, Ampofo E
Biomedicines 2022 Apr 21;10(5)
Biomedicines 2022 Apr 21;10(5)
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
Gruijs da Silva LA, Simonetti F, Hutten S, Riemenschneider H, Sternburg EL, Pietrek LM, Gebel J, Dötsch V, Edbauer D, Hummer G, Stelzl LS, Dormann D
The EMBO journal 2022 Apr 19;41(8):e108443
The EMBO journal 2022 Apr 19;41(8):e108443
Secondary structure RNA elements control the cleavage activity of DICER.
Nguyen TD, Trinh TA, Bao S, Nguyen TA
Nature communications 2022 Apr 19;13(1):2138
Nature communications 2022 Apr 19;13(1):2138
Osteopontin is required for the maintenance of leukemia stem cells in acute myeloid leukemia.
Zhou J, Chen X, Zhou P, Sun X, Chen Y, Li M, Chu Y, Zhou J, Hu X, Luo Y, Yuan W, Wang G
Biochemical and biophysical research communications 2022 Apr 16;600:29-34
Biochemical and biophysical research communications 2022 Apr 16;600:29-34
ILF3 represses repeat-derived microRNAs targeting RIG-I mediated type I interferon response.
Chen G, Yang Y, Wu QJ, Cao L, Ruan W, Shao C, Jiang L, Tang P, Ma S, Jiang A, Wang Z, Wu K, Zhang QC, Fu XD, Zhou Y
Journal of molecular biology 2022 Apr 15;434(7):167469
Journal of molecular biology 2022 Apr 15;434(7):167469
Brown adipose tissue involution associated with progressive restriction in progenitor competence.
Huang Z, Zhang Z, Moazzami Z, Heck R, Hu P, Nanda H, Ren K, Sun Z, Bartolomucci A, Gao Y, Chung D, Zhu W, Shen S, Ruan HB
Cell reports 2022 Apr 12;39(2):110575
Cell reports 2022 Apr 12;39(2):110575
Long noncoding RNA SH3PXD2A-AS1 promotes NSCLC proliferation and accelerates cell cycle progression by interacting with DHX9.
Zhou Y, Yong H, Cui W, Chu S, Li M, Li Z, Bai J, Zhang H
Cell death discovery 2022 Apr 11;8(1):192
Cell death discovery 2022 Apr 11;8(1):192
Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation.
Jo SL, Yang H, Lee SR, Heo JH, Lee HW, Hong EJ
Nutrients 2022 Apr 11;14(8)
Nutrients 2022 Apr 11;14(8)
SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer.
Li TJ, Jin KZ, Li H, Ye LY, Li PC, Jiang B, Lin X, Liao ZY, Zhang HR, Shi SM, Lin MX, Fei QL, Xiao ZW, Xu HX, Liu L, Yu XJ, Wu WD
Cancer letters 2022 Apr 1;530:142-155
Cancer letters 2022 Apr 1;530:142-155
BRCC36 prevents vascular calcification in chronic kidney disease through the β-catenin signalling pathway.
Xie C, Chen C, Wu L, Xiong Y, Xing C, Mao H
Experimental cell research 2022 Apr 1;413(1):113051
Experimental cell research 2022 Apr 1;413(1):113051
Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.
Liu Z, Yan M, Lei W, Jiang R, Dai W, Chen J, Wang C, Li L, Wu M, Nian X, Li D, Sun D, Lv X, Wang C, Xie C, Yao L, Wu C, Hu J, Xiao N, Mo W, Wang Z, Zhang L
The Journal of clinical investigation 2022 Apr 1;132(7)
The Journal of clinical investigation 2022 Apr 1;132(7)
Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy.
Zhao M, Wei H, Li C, Zhan R, Liu C, Gao J, Yi Y, Cui X, Shan W, Ji L, Pan B, Cheng S, Song M, Sun H, Jiang H, Cai J, Garcia-Barrio MT, Chen YE, Meng X, Dong E, Wang DW, Zheng L
Nature communications 2022 Apr 1;13(1):1757
Nature communications 2022 Apr 1;13(1):1757
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
Bernatik O, Paclikova P, Kotrbova A, Bryja V, Cajanek L
Frontiers in cell and developmental biology 2021;9:623753
Frontiers in cell and developmental biology 2021;9:623753
Impaired Retrograde Transport Due to Lack of TBC1D5 Contributes to the Trafficking Defect of Lysosomal Cathepsins in Ischemic/Hypoxic Cardiomyocytes.
Cui L, Zhang Q, Huang Y, Yang L, Zhang J, Jiang X, Jia J, Lv Y, Zhang D, Huang Y
Frontiers in cardiovascular medicine 2021;8:796254
Frontiers in cardiovascular medicine 2021;8:796254
Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.
Lin Z, Lin Z, Zhao Y, Cheng N, Zhang D, Lin J, Zhang H, Lin D
Frontiers in veterinary science 2021;8:772687
Frontiers in veterinary science 2021;8:772687
PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca(2+)/Calpain/VE-Cadherin Signaling.
Guo XW, Zhang H, Huang JQ, Wang SN, Lu Y, Cheng B, Dong SH, Wang YY, Li FS, Li YW
Frontiers in molecular biosciences 2021;8:725274
Frontiers in molecular biosciences 2021;8:725274
FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.
Zhuang L, Mao Y, Liu Z, Li C, Jin Q, Lu L, Tao R, Yan X, Chen K
Frontiers in cardiovascular medicine 2021;8:722908
Frontiers in cardiovascular medicine 2021;8:722908
Sirt3 Maintains Microvascular Endothelial Adherens Junction Integrity to Alleviate Sepsis-Induced Lung Inflammation by Modulating the Interaction of VE-Cadherin and β-Catenin.
Chen DQ, Shen MJ, Wang H, Li Y, Tang AL, Li S, Xiong MC, Guo Y, Zhang GQ
Oxidative medicine and cellular longevity 2021;2021:8978795
Oxidative medicine and cellular longevity 2021;2021:8978795
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Su X, Yang Y, Guo C, Zhang R, Sun S, Wang Y, Qiao Q, Fu Y, Pang Q
Oxidative medicine and cellular longevity 2021;2021:5549047
Oxidative medicine and cellular longevity 2021;2021:5549047
NR1D1 Deletion Induces Rupture-Prone Vulnerable Plaques by Regulating Macrophage Pyroptosis via the NF-κB/NLRP3 Inflammasome Pathway.
Wu Z, Liao F, Luo G, Qian Y, He X, Xu W, Ding S, Pu J
Oxidative medicine and cellular longevity 2021;2021:5217572
Oxidative medicine and cellular longevity 2021;2021:5217572
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Lin Y, Xie Y, Hao Z, Bi H, Liu Y, Yang X, Xia Y
Journal of immunology research 2021;2021:5151168
Journal of immunology research 2021;2021:5151168
Chirality and asymmetry increase the potency of candidate ADRM1/RPN13 inhibitors.
Anchoori RK, George L, Tseng SH, Lam B, Polkampally S, Amiano AD, Foran P, Tsingine H, Samanapally H, Carrizo Velasquez F, Das S, Xing D, Bin Salam A, Karanam B, Hung CF, Roden RBS
PloS one 2021;16(9):e0256937
PloS one 2021;16(9):e0256937
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
Huang GZ, Wu QQ, Zheng ZN, Shao TR, Li F, Lu XY, Ye HY, Chen GX, Song YX, Zeng WS, Ai YL, Lv XZ
OncoTargets and therapy 2021;14:1275-1289
OncoTargets and therapy 2021;14:1275-1289
N6-methyladenosine regulates ATM expression and downstream signaling.
Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051
Journal of Cancer 2021;12(23):7041-7051
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Chen L, Yi C, Li W, Tseng Y, Zhang J, Liu J
Journal of Cancer 2021;12(1):89-98
Journal of Cancer 2021;12(1):89-98
Small Molecule Palmatine Targeting Musashi-2 in Colorectal Cancer.
Zhang X, Su K, Liu Y, Zhu D, Pan Y, Ke X, Qu Y
Frontiers in pharmacology 2021;12:793449
Frontiers in pharmacology 2021;12:793449
Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway.
Lv X, Yao T, He R, He Y, Li M, Han Y, Zhang Y, Long L, Jiang G, Cheng X, Xie Y, Huang L, Peng Z, Hu G, Li Q, Tao L, Meng J
Frontiers in pharmacology 2021;12:772031
Frontiers in pharmacology 2021;12:772031
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Han Y, Jiang M, He R, Lv X, Liao X, He Y, Zhang F, Long L, Jiang G, Peng Z, Tao L, Hu G, Meng J
Frontiers in pharmacology 2021;12:713572
Frontiers in pharmacology 2021;12:713572
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Tong X, Zhang S, Wang D, Zhang L, Huang J, Zhang T, Fan H
Frontiers in pharmacology 2021;12:709819
Frontiers in pharmacology 2021;12:709819
Melatonin Alleviates Renal Injury in Mouse Model of Sepsis.
Chen L, Han Z, Shi Z, Liu C, Lu Q
Frontiers in pharmacology 2021;12:697643
Frontiers in pharmacology 2021;12:697643
Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands.
SenGupta S, Hein LE, Xu Y, Zhang J, Konwerski JR, Li Y, Johnson C, Cai D, Smith JL, Parent CA
Frontiers in immunology 2021;12:659996
Frontiers in immunology 2021;12:659996
Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development.
Guo S, Meng L, Liu H, Yuan L, Zhao N, Ni J, Zhang Y, Ben J, Li YP, Ma J
Theranostics 2021;11(9):4316-4334
Theranostics 2021;11(9):4316-4334
SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.
Guan C, Huang X, Yue J, Xiang H, Shaheen S, Jiang Z, Tao Y, Tu J, Liu Z, Yao Y, Yang W, Hou Z, Liu J, Yang XD, Zou Q, Su B, Liu Z, Ni J, Cheng J, Wu X
Theranostics 2021;11(8):3981-3995
Theranostics 2021;11(8):3981-3995
NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation.
Fan XJ, Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Feng WX, Wang YN, Liu Q, Hung MC, Wan XB
American journal of cancer research 2021;11(6):2838-2852
American journal of cancer research 2021;11(6):2838-2852
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis.
Zheng Q, Li P, Zhou X, Qiang Y, Fan J, Lin Y, Chen Y, Guo J, Wang F, Xue H, Xiong J, Li F
Theranostics 2021;11(18):8674-8691
Theranostics 2021;11(18):8674-8691
SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux.
Zhou F, Zhang L, Zhu K, Bai M, Zhang Y, Zhu Q, Wang S, Sheng C, Yuan M, Liu Y, Lu J, Shao L, Wang X, Zhou L
Theranostics 2021;11(10):4825-4838
Theranostics 2021;11(10):4825-4838
Combination of Auranofin and ICG-001 Suppress the Proliferation and Metastasis of Colon Cancer.
Lin Z, Li Q, Zhao Y, Lin Z, Cheng N, Zhang D, Liu G, Lin J, Zhang H, Lin D
Frontiers in oncology 2021;11:738085
Frontiers in oncology 2021;11:738085
Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma.
Zhu Y, Pu Z, Li Z, Lin Y, Li N, Peng F
Frontiers in oncology 2021;11:700528
Frontiers in oncology 2021;11:700528
SLC25A21 Suppresses Cell Growth in Bladder Cancer via an Oxidative Stress-Mediated Mechanism.
Wang Y, Gao J, Hu S, Zeng W, Yang H, Chen H, Wang S
Frontiers in oncology 2021;11:682710
Frontiers in oncology 2021;11:682710
ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition.
Cao C, He K, Li S, Ge Q, Liu L, Zhang Z, Zhang H, Wang X, Sun X, Ding L
Cellular signalling 2021 Sep;85:110062
Cellular signalling 2021 Sep;85:110062
Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats.
Otsuka S, Sakakima H, Tani A, Nakanishi K, Takada S, Norimatsu K, Maejima H, Maruyama I
Brain structure & function 2021 Sep;226(7):2169-2180
Brain structure & function 2021 Sep;226(7):2169-2180
OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.
Ge X, Peng X, Li M, Ji F, Chen J, Zhang D
Pathology, research and practice 2021 Sep;225:153580
Pathology, research and practice 2021 Sep;225:153580
CUL4(high) Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.
Wang Y, Yan F, Nasar A, Chen ZS, Altorki NK, Stiles B, Narula N, Zhou P
The American journal of pathology 2021 Sep;191(9):1638-1650
The American journal of pathology 2021 Sep;191(9):1638-1650
PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons.
Marcus JM, Hossain MI, Gagné JP, Poirier GG, McMahon LL, Cowell RM, Andrabi SA
Neurochemistry international 2021 Sep;148:105077
Neurochemistry international 2021 Sep;148:105077
Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway.
Li R, Zhu W, Huang P, Yang Y, Luo F, Dai W, Shen L, Pei W, Huang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Sep;141:111803
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Sep;141:111803
Down-regulation of Polo-like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer.
Yang Z, Sun H, Ma W, Wu K, Peng G, Ou T, Wu S
FEBS open bio 2021 Sep;11(9):2631-2646
FEBS open bio 2021 Sep;11(9):2631-2646
Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1.
Zhu M, Liang Z, Pan J, Zhang X, Xue R, Cao G, Hu X, Gong C
Molecular therapy. Nucleic acids 2021 Sep 3;25:668-682
Molecular therapy. Nucleic acids 2021 Sep 3;25:668-682
Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells.
Yang WB, Wu AC, Hsu TI, Liou JP, Lo WL, Chang KY, Chen PY, Kikkawa U, Yang ST, Kao TJ, Chen RM, Chang WC, Ko CY, Chuang JY
Cell death & disease 2021 Sep 28;12(10):884
Cell death & disease 2021 Sep 28;12(10):884
Androgen-dependent and DNA-binding-independent association of androgen receptor with chromatic regions coding androgen-induced noncoding RNAs.
Sawada T, Nishimura K, Mori J, Kanemoto Y, Kouzmenko A, Amano R, Hayakawa A, Tokiwa S, Shimmura H, Kato S
Bioscience, biotechnology, and biochemistry 2021 Sep 22;85(10):2121-2130
Bioscience, biotechnology, and biochemistry 2021 Sep 22;85(10):2121-2130
Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers.
Xie T, St Pierre SR, Olaranont N, Brown LE, Wu M, Sun Y
eLife 2021 Sep 20;10
eLife 2021 Sep 20;10
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways.
Chen S, Li Y, Chu B, Yuan L, Liu N, Zhu Y, Wang J
Microorganisms 2021 Sep 17;9(9)
Microorganisms 2021 Sep 17;9(9)
EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.
Liu T, Li T, Chen X, Li Z, Feng M, Yao W, Wan L, Zhang C, Zhang Y
Journal of neuroinflammation 2021 Sep 16;18(1):211
Journal of neuroinflammation 2021 Sep 16;18(1):211
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Hypoxia regulates overall mRNA homeostasis by inducing Met(1)-linked linear ubiquitination of AGO2 in cancer cells.
Zhang H, Zhao X, Guo Y, Chen R, He J, Li L, Qiang Z, Yang Q, Liu X, Huang C, Lu R, Fang J, Cao Y, Huang J, Wang Y, Huang J, Chen GQ, Cheng J, Yu J
Nature communications 2021 Sep 13;12(1):5416
Nature communications 2021 Sep 13;12(1):5416
Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.
Zhou H, Su H, Chen W
International journal of molecular sciences 2021 Sep 1;22(17)
International journal of molecular sciences 2021 Sep 1;22(17)
Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovarian cancer cells.
Amaya C, Luo S, Baigorri J, Baucells R, Smith ER, Xu XX
BMC cancer 2021 Sep 1;21(1):981
BMC cancer 2021 Sep 1;21(1):981
Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure.
Li H, Zhao Z, Li X, Qin L, Wen W, Chen H, Qian P
Virologica Sinica 2021 Oct;36(5):1210-1219
Virologica Sinica 2021 Oct;36(5):1210-1219
HOIL-1-catalysed, ester-linked ubiquitylation restricts IL-18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages.
Petrova T, Zhang J, Nanda SK, Figueras-Vadillo C, Cohen P
The FEBS journal 2021 Oct;288(20):5909-5924
The FEBS journal 2021 Oct;288(20):5909-5924
Loss of E-cadherin due to road dust PM(2.5) activates the EGFR in human pharyngeal epithelial cells.
Tung NT, Ho KF, Niu X, Sun J, Shen Z, Wu F, Cao J, Dung HB, Thuy TPC, Hsiao TC, Liu WT, Chuang HC
Environmental science and pollution research international 2021 Oct;28(38):53872-53887
Environmental science and pollution research international 2021 Oct;28(38):53872-53887
Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells.
Wang Q, Wu H, Hu J, Fu H, Qu Y, Yang Y, Cai KQ, Efimov A, Wu M, Yen T, Wang Y, Yang ZJ
Molecular cancer research : MCR 2021 Oct;19(10):1651-1665
Molecular cancer research : MCR 2021 Oct;19(10):1651-1665
ORMDL1 is upregulated and associated with favorable outcomes in colorectal cancer.
Wang Q, Liu W, Chen S, Luo Q, Li Y, Peng S, Wang H, Liu X, Chen D
Translational oncology 2021 Oct;14(10):101171
Translational oncology 2021 Oct;14(10):101171
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Liang Y, Zhang M, Zhou P, Liu M, Li J, Wang Y
Bioorganic chemistry 2021 Oct;115:105239
Bioorganic chemistry 2021 Oct;115:105239
Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium.
Zhang X, Wang Z, Xu Q, Chen Y, Liu W, Zhong T, Li H, Quan C, Zhang L, Cui CP
iScience 2021 Oct 22;24(10):103097
iScience 2021 Oct 22;24(10):103097
The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle.
Rigillo G, Basile V, Belluti S, Ronzio M, Sauta E, Ciarrocchi A, Latella L, Saclier M, Molinari S, Vallarola A, Messina G, Mantovani R, Dolfini D, Imbriano C
Nature communications 2021 Oct 14;12(1):6013
Nature communications 2021 Oct 14;12(1):6013
Preconditioning Exercise in Rats Attenuates Early Brain Injury Resulting from Subarachnoid Hemorrhage by Reducing Oxidative Stress, Inflammation, and Neuronal Apoptosis.
Otsuka S, Setoyama K, Takada S, Nakanishi K, Terashi T, Norimatsu K, Tani A, Sakakima H, Maruyama I, Tancharoen S, Tanaka E, Kikuchi K
Molecular neurobiology 2021 Nov;58(11):5602-5617
Molecular neurobiology 2021 Nov;58(11):5602-5617
Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress.
Wu L, He S, Ye W, Shen J, Zhao K, Zhang Y, Zhang R, Wei J, Cao S, Chen K, Le R, Xi C, Kou X, Zhao Y, Wang H, Kang L, Gao S
Cell proliferation 2021 Nov;54(11):e13133
Cell proliferation 2021 Nov;54(11):e13133
Cycloastragenol and Astragaloside IV activate telomerase and protect nucleus pulposus cells against high glucose-induced senescence and apoptosis.
Hong H, Xiao J, Guo Q, Du J, Jiang Z, Lu S, Zhang H, Zhang X, Wang X
Experimental and therapeutic medicine 2021 Nov;22(5):1326
Experimental and therapeutic medicine 2021 Nov;22(5):1326
Selective autophagy receptor SQSTM1/ p62 inhibits Seneca Valley virus replication by targeting viral VP1 and VP3.
Wen W, Li X, Yin M, Wang H, Qin L, Li H, Liu W, Zhao Z, Zhao Q, Chen H, Hu J, Qian P
Autophagy 2021 Nov;17(11):3763-3775
Autophagy 2021 Nov;17(11):3763-3775
Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.
Hao W, Hao C, Wu C, Xu Y, Wu S, Lu X, Yang J, Jin C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112591
Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.
Xing Y, Wang L, Xu G, Guo S, Zhang M, Cheng G, Liu Y, Liu J
Research in veterinary science 2021 Nov;140:18-25
Research in veterinary science 2021 Nov;140:18-25
Caspase-3/NLRP3 signaling in the mesenchymal stromal niche regulates myeloid-biased hematopoiesis.
Zhang J, Chen Y, Yin D, Feng F, An Q, Liu Z, An N, Xu J, Yi J, Gu S, Yin W, Wang Y, Hu X
Stem cell research & therapy 2021 Nov 20;12(1):579
Stem cell research & therapy 2021 Nov 20;12(1):579
Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
Wang D, Ye Z, Wei W, Yu J, Huang L, Zhang H, Yue J
eLife 2021 Nov 19;10
eLife 2021 Nov 19;10
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Pérez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD
Nature communications 2021 Nov 18;12(1):6671
Nature communications 2021 Nov 18;12(1):6671
Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients.
Belluti S, Semeghini V, Rigillo G, Ronzio M, Benati D, Torricelli F, Reggiani Bonetti L, Carnevale G, Grisendi G, Ciarrocchi A, Dominici M, Recchia A, Dolfini D, Imbriano C
Journal of experimental & clinical cancer research : CR 2021 Nov 15;40(1):362
Journal of experimental & clinical cancer research : CR 2021 Nov 15;40(1):362
Screening and identification of autophagy-related biomarkers for oral squamous cell carcinoma (OSCC) via integrated bioinformatics analysis.
Huang GZ, Lu ZY, Rao Y, Gao H, Lv XZ
Journal of cellular and molecular medicine 2021 May;25(9):4444-4454
Journal of cellular and molecular medicine 2021 May;25(9):4444-4454
BCL7C suppresses ovarian cancer growth by inactivating mutant p53.
Huang C, Hao Q, Shi G, Zhou X, Zhang Y
Journal of molecular cell biology 2021 May 7;13(2):141-150
Journal of molecular cell biology 2021 May 7;13(2):141-150
Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes.
Chen F, Jiao XF, Meng F, Wang YS, Ding ZM, Miao YL, Xiong JJ, Huo LJ
International journal of molecular sciences 2021 May 3;22(9)
International journal of molecular sciences 2021 May 3;22(9)
One Week of CDAHFD Induces Steatohepatitis and Mitochondrial Dysfunction with Oxidative Stress in Liver.
Sugasawa T, Ono S, Yonamine M, Fujita SI, Matsumoto Y, Aoki K, Nakano T, Tamai S, Yoshida Y, Kawakami Y, Takekoshi K
International journal of molecular sciences 2021 May 29;22(11)
International journal of molecular sciences 2021 May 29;22(11)
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS, Manis M, Schroeder C, Yin Z, Madore C, Butovsky O, Artyomov M, Ulrich JD, Holtzman DM
Neuron 2021 May 19;109(10):1657-1674.e7
Neuron 2021 May 19;109(10):1657-1674.e7
LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA.
Li D, Wang X, Li G, Dang Y, Zhao S, Qin Y
Cell death discovery 2021 May 16;7(1):107
Cell death discovery 2021 May 16;7(1):107
Effect of low-intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer's disease.
Nakanishi K, Sakakima H, Norimatsu K, Otsuka S, Takada S, Tani A, Kikuchi K
Experimental neurology 2021 Mar;337:113590
Experimental neurology 2021 Mar;337:113590
TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication.
Nie X, Xiao D, Ge Y, Xie Y, Zhou H, Zheng T, Li X, Liu H, Huang H, Zhao Y
Cell death and differentiation 2021 Mar;28(3):1062-1075
Cell death and differentiation 2021 Mar;28(3):1062-1075
NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions.
Liu Z, Chen Y, Niu B, Yin D, Feng F, Gu S, An Q, Xu J, An N, Zhang J, Yi J, Yin W, Qin X, Hu X
Clinical and translational medicine 2021 Mar;11(3):e373
Clinical and translational medicine 2021 Mar;11(3):e373
lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1.
Li D, Wang X, Dang Y, Zhang X, Zhao S, Lu G, Chan WY, Leung PCK, Qin Y
Molecular therapy. Nucleic acids 2021 Mar 5;23:132-141
Molecular therapy. Nucleic acids 2021 Mar 5;23:132-141
Efficacy and long-term safety of CRISPR/Cas9 genome editing in the SOD1-linked mouse models of ALS.
Deng HX, Zhai H, Shi Y, Liu G, Lowry J, Liu B, Ryan ÉB, Yan J, Yang Y, Zhang N, Yang Z, Liu E, Ma YC, Siddique T
Communications biology 2021 Mar 25;4(1):396
Communications biology 2021 Mar 25;4(1):396
Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma.
Peng Y, Zhang Z, Zhang A, Liu C, Sun Y, Peng Z, Liu Y
Aging 2021 Mar 24;13(7):10312-10325
Aging 2021 Mar 24;13(7):10312-10325
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Shangguan X, He J, Ma Z, Zhang W, Ji Y, Shen K, Yue Z, Li W, Xin Z, Zheng Q, Cao Y, Pan J, Dong B, Cheng J, Wang Q, Xue W
Nature communications 2021 Mar 22;12(1):1812
Nature communications 2021 Mar 22;12(1):1812
Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.
Shen Z, Ji K, Cai Z, Huang C, He X, Xu H, Chen G
Aging 2021 Mar 19;13(7):9820-9837
Aging 2021 Mar 19;13(7):9820-9837
Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants.
Ben Saad A, Vauthier V, Tóth Á, Janaszkiewicz A, Durand-Schneider AM, Bruneau A, Delaunay JL, Lapalus M, Mareux E, Garcin I, Gonzales E, Housset C, Aït-Slimane T, Jacquemin E, Di Meo F, Falguières T
Liver international : official journal of the International Association for the Study of the Liver 2021 Jun;41(6):1344-1357
Liver international : official journal of the International Association for the Study of the Liver 2021 Jun;41(6):1344-1357
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
Li SS, Chen DM, Chen LB, Wei H, Wang JL, Xiao J, Huang YH, Lian YF
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.
Sun XH, Xiao HM, Zhang M, Lin ZY, Yang Y, Chen R, Liu PQ, Huang KP, Huang HQ
Biochemical pharmacology 2021 Jun;188:114562
Biochemical pharmacology 2021 Jun;188:114562
RAB10 Interacts with ABCB4 and Regulates Its Intracellular Traffic.
Ben Saad A, Vauthier V, Lapalus M, Mareux E, Bennana E, Durand-Schneider AM, Bruneau A, Delaunay JL, Gonzales E, Housset C, Aït-Slimane T, Guillonneau F, Jacquemin E, Falguières T
International journal of molecular sciences 2021 Jun 30;22(13)
International journal of molecular sciences 2021 Jun 30;22(13)
Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.
Wang M, Feng LR, Li ZL, Ma KG, Chang KW, Chen XL, Yang PB, Ji SF, Ma YB, Han H, Ruganzua JB, Yang WN, Qian YH
Journal of neuroinflammation 2021 Jun 28;18(1):146
Journal of neuroinflammation 2021 Jun 28;18(1):146
The Anti-Tumor Effect and Underlying Apoptotic Mechanism of Ginsenoside Rk1 and Rg5 in Human Liver Cancer Cells.
Chen C, Lv Q, Li Y, Jin YH
Molecules (Basel, Switzerland) 2021 Jun 27;26(13)
Molecules (Basel, Switzerland) 2021 Jun 27;26(13)
Nuclear Lamin A/C Expression Is a Key Determinant of Paclitaxel Sensitivity.
Smith ER, Leal J, Amaya C, Li B, Xu XX
Molecular and cellular biology 2021 Jun 23;41(7):e0064820
Molecular and cellular biology 2021 Jun 23;41(7):e0064820
Nitrogen-Doped Multiwalled Carbon Nanotubes Enhance Bone Remodeling through Immunomodulatory Functions.
Li H, He D, Xiao X, Yu G, Hu G, Zhang W, Wen X, Lin Y, Li X, Lin H, Diao Y, Tang Y
ACS applied materials & interfaces 2021 Jun 2;13(21):25290-25305
ACS applied materials & interfaces 2021 Jun 2;13(21):25290-25305
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance.
Liu Y, Liang G, Xu H, Dong W, Dong Z, Qiu Z, Zhang Z, Li F, Huang Y, Li Y, Wu J, Yin S, Zhang Y, Guo P, Liu J, Xi JJ, Jiang P, Han D, Yang CG, Xu MM
Cell metabolism 2021 Jun 1;33(6):1221-1233.e11
Cell metabolism 2021 Jun 1;33(6):1221-1233.e11
MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway.
Ling Q, Li F, Zhang X, Mao S, Lin X, Pan J, Ye W, Wei W, Qian Y, Hu C, Huang X, Wang J, Wang H, Huang J, Wang Y, Jin J
EBioMedicine 2021 Jul;69:103441
EBioMedicine 2021 Jul;69:103441
Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression.
Zhang P, Wang J, Luo W, Yuan J, Cui C, Guo L, Wu C
American journal of respiratory cell and molecular biology 2021 Jul;65(1):54-69
American journal of respiratory cell and molecular biology 2021 Jul;65(1):54-69
Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome.
Cousin MA, Creighton BA, Breau KA, Spillmann RC, Torti E, Dontu S, Tripathi S, Ajit D, Edwards RJ, Afriyie S, Bay JC, Harper KM, Beltran AA, Munoz LJ, Falcon Rodriguez L, Stankewich MC, Person RE, Si Y, Normand EA, Blevins A, May AS, Bier L, Aggarwal V, Mancini GMS, van Slegtenhorst MA, Cremer K, Becker J, Engels H, Aretz S, MacKenzie JJ, Brilstra E, van Gassen KLI, van Jaarsveld RH, Oegema R, Parsons GM, Mark P, Helbig I, McKeown SE, Stratton R, Cogne B, Isidor B, Cacheiro P, Smedley D, Firth HV, Bierhals T, Kloth K, Weiss D, Fairley C, Shieh JT, Kritzer A, Jayakar P, Kurtz-Nelson E, Bernier RA, Wang T, Eichler EE, van de Laar IMBH, McConkie-Rosell A, McDonald MT, Kemppainen J, Lanpher BC, Schultz-Rogers LE, Gunderson LB, Pichurin PN, Yoon G, Zech M, Jech R, Winkelmann J, Undiagnosed Diseases Network, Genomics England Research Consortium, Beltran AS, Zimmermann MT, Temple B, Moy SS, Klee EW, Tan QK, Lorenzo DN
Nature genetics 2021 Jul;53(7):1006-1021
Nature genetics 2021 Jul;53(7):1006-1021
Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.
Chen X, Xu Y, Tu W, Huang F, Zuo Y, Zhang HG, Jin L, Feng Q, Ren T, He J, Miao Y, Yuan Y, Zhao Q, Liu J, Zhang R, Zhu L, Qian F, Zhu C, Zheng H, Wang J
Immunology 2021 Jul;163(3):278-292
Immunology 2021 Jul;163(3):278-292
HSV-1-encoded ICP0 degrades the host deubiquitinase BRCC36 to antagonize interferon antiviral response.
Zhang L, Huang F, Liu J, Xu Y, Miao Y, Yuan Y, Chen X, Zhang HG, Wang J, Zheng H, Zuo Y
Molecular immunology 2021 Jul;135:28-35
Molecular immunology 2021 Jul;135:28-35
Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.
Nakayama S, Yano T, Namba T, Konishi S, Takagishi M, Herawati E, Nishida T, Imoto Y, Ishihara S, Takahashi M, Furuta K, Oiwa K, Tamura A, Tsukita S
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.
Zhang W, Zhang R, Zeng Y, Li Y, Chen Y, Zhou J, Zhang Y, Wang A, Zhu J, Liu Z, Yan Z, Huang JA
Cell death & disease 2021 Jul 31;12(8):755
Cell death & disease 2021 Jul 31;12(8):755
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, Xavier-Ferrucio J, Jin S, Tran NT, Liu SM, Sun CW, Zhu Y, Zhao Q, Chen Y, Cable L, Shen Y, Liu J, Qu CK, Han X, Klug CA, Bhatia R, Chen Y, Nimer SD, Zheng YG, Iancu-Rubin C, Jin J, Deng H, Krause DS, Xiang J, Verma A, Luo M, Zhao X
Cell reports 2021 Jul 27;36(4):109421
Cell reports 2021 Jul 27;36(4):109421
Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3.
Luo MT, Mu D, Yang X, Luo RH, Zheng HY, Chen M, Guo YQ, Zheng YT
Journal of virology 2021 Jul 26;95(16):e0002021
Journal of virology 2021 Jul 26;95(16):e0002021
Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB.
Ge W, Wang Y, Zheng S, Zhao D, Wang X, Zhang X, Hu Y
Cell death discovery 2021 Jul 26;7(1):195
Cell death discovery 2021 Jul 26;7(1):195
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
Chang H, Xu Q, Li J, Li M, Zhang Z, Ma H, Yang X
Cell death & disease 2021 Jul 21;12(8):725
Cell death & disease 2021 Jul 21;12(8):725
Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.
Yu L, Liu S, Wang C, Zhang C, Wen Y, Zhang K, Chen S, Huang H, Liu Y, Wu L, Han Z, Chen X, Li Z, Liu N
Stem cell research & therapy 2021 Jul 2;12(1):379
Stem cell research & therapy 2021 Jul 2;12(1):379
Antibody Self-Assembly Maximizes Cytoplasmic Immunostaining Accuracy of Compact Quantum Dots.
Ma L, Geng J, Kolossov VL, Han Z, Pei Y, Lim SJ, Kilian KA, Smith AM
Chemistry of materials : a publication of the American Chemical Society 2021 Jul 13;33(13):4877-4889
Chemistry of materials : a publication of the American Chemical Society 2021 Jul 13;33(13):4877-4889
Seneca Valley Virus 3C Protease Induces Pyroptosis by Directly Cleaving Porcine Gasdermin D.
Wen W, Li X, Wang H, Zhao Q, Yin M, Liu W, Chen H, Qian P
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 1;207(1):189-199
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 1;207(1):189-199
Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway.
Gan W, Li X, Cui Y, Xiao T, Liu R, Wang M, Wei Y, Cui M, Ren S, Helian K, Ning W, Zhou H, Yang C
International immunopharmacology 2021 Jan;90:107230
International immunopharmacology 2021 Jan;90:107230
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.
Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR
Science advances 2021 Jan;7(5)
Science advances 2021 Jan;7(5)
The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors.
Goss KL, Koppenhafer SL, Waters T, Terry WW, Wen KK, Wu M, Ostergaard J, Gordon PM, Gordon DJ
Oncogene 2021 Jan;40(3):564-577
Oncogene 2021 Jan;40(3):564-577
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Yang Y, Li J, Zhang L, Lin Z, Xiao H, Sun X, Zhang M, Liu P, Huang H
Pharmacological research 2021 Jan;163:105333
Pharmacological research 2021 Jan;163:105333
ATG5 is instrumental in the transition from autophagy to apoptosis during the degeneration of tick salivary glands.
Wang Y, Zhang H, Luo L, Zhou Y, Cao J, Xuan X, Suzuki H, Zhou J
PLoS neglected tropical diseases 2021 Jan;15(1):e0009074
PLoS neglected tropical diseases 2021 Jan;15(1):e0009074
Identification of fusarielin M as a novel inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB).
Chen D, Liu L, Lu Y, Chen S
Bioorganic chemistry 2021 Jan;106:104495
Bioorganic chemistry 2021 Jan;106:104495
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
McKinzey DR, Gomathinayagam S, Griffin WC, Klinzing KN, Jeffries EP, Rajkovic A, Trakselis MA
The Journal of biological chemistry 2021 Jan-Jun;296:100355
The Journal of biological chemistry 2021 Jan-Jun;296:100355
FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation.
Liu X, Ge J, Chen C, Shen Y, Xie J, Zhu X, Liu M, Hu J, Chen L, Guo L, Zhou Q, Yan X, Qiu Y, Wan R, Marian AJ, Hong K
Cell death & disease 2021 Jan 5;12(1):25
Cell death & disease 2021 Jan 5;12(1):25
Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases.
De Cesare V, Carbajo Lopez D, Mabbitt PD, Fletcher AJ, Soetens M, Antico O, Wood NT, Virdee S
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)
Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.
Xu G, Fu S, Zhan X, Wang Z, Zhang P, Shi W, Qin N, Chen Y, Wang C, Niu M, Guo Y, Wang J, Bai Z, Xiao X
JCI insight 2021 Jan 25;6(2)
JCI insight 2021 Jan 25;6(2)
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150(glued).
Suh BK, Lee SA, Park C, Suh Y, Kim SJ, Woo Y, Nhung TTM, Lee SB, Mun DJ, Goo BS, Choi HS, Kim SJ, Park SK
Molecular brain 2021 Jan 18;14(1):14
Molecular brain 2021 Jan 18;14(1):14
In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma.
Chen H, Sa G, Li L, He S, Wu T
European journal of pharmacology 2021 Jan 15;891:173757
European journal of pharmacology 2021 Jan 15;891:173757
Enterovirus D68 Protease 2A(pro) Targets TRAF3 To Subvert Host Innate Immune Responses.
Kang J, Pang Z, Zhou Z, Li X, Liu S, Cheng J, Liu P, Tan W, Wang Z, Wang T
Journal of virology 2021 Jan 13;95(3)
Journal of virology 2021 Jan 13;95(3)
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Li Y, Zhao Y, Li Y, Zhang X, Li C, Long N, Chen X, Bao L, Zhou J, Xie Y
Journal of physiology and biochemistry 2021 Feb;77(1):93-104
Journal of physiology and biochemistry 2021 Feb;77(1):93-104
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer.
Liu Y, Huang Z, Wei Y, Zhang M, Li X, Yang S, Wang H
Cancer immunology, immunotherapy : CII 2021 Feb;70(2):275-287
Cancer immunology, immunotherapy : CII 2021 Feb;70(2):275-287
Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells.
Zhang Y, Elechalawar CK, Hossen MN, Francek ER, Dey A, Wilhelm S, Bhattacharya R, Mukherjee P
Bioactive materials 2021 Feb;6(2):326-332
Bioactive materials 2021 Feb;6(2):326-332
BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability.
Cheng Q, Feng Q, Xu Y, Zuo Y, Liu J, Yuan Y, Miao Y, Liu Y, Lei L, Guo T, Zhang L, Wu D, Zheng H
European journal of immunology 2021 Feb;51(2):296-310
European journal of immunology 2021 Feb;51(2):296-310
Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.
Redl E, Sheibani-Tezerji R, Cardona CJ, Hamminger P, Timelthaler G, Hassler MR, Zrimšek M, Lagger S, Dillinger T, Hofbauer L, Draganić K, Tiefenbacher A, Kothmayer M, Dietz CH, Ramsahoye BH, Kenner L, Bock C, Seiser C, Ellmeier W, Schweikert G, Egger G
Life science alliance 2021 Feb;4(2)
Life science alliance 2021 Feb;4(2)
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense.
Guo X, Ma P, Li Y, Yang Y, Wang C, Xu T, Wang H, Li C, Mao B, Qi X
Cell death and differentiation 2021 Feb;28(2):640-656
Cell death and differentiation 2021 Feb;28(2):640-656
Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death.
Liu Y, Wang Y, Liu J, Kang R, Tang D
Cancer gene therapy 2021 Feb;28(1-2):55-63
Cancer gene therapy 2021 Feb;28(1-2):55-63
Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma.
Wu H, Chen Y, Li B, Li C, Guo J, You J, Hu X, Kuang D, Qi S, Liu P, Li L, Xu C
Biochemical pharmacology 2021 Feb;184:114353
Biochemical pharmacology 2021 Feb;184:114353
A newly identified small molecular compound acts as a protein kinase inhibitor to suppress metastasis of colorectal cancer.
Qi L, Zhang Y, Song F, Han Y, Ding Y
Bioorganic chemistry 2021 Feb;107:104625
Bioorganic chemistry 2021 Feb;107:104625
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.
Lee SB, Park J, Kwak Y, Park YU, Nhung TTM, Suh BK, Woo Y, Suh Y, Cho E, Cho S, Park SK
Translational psychiatry 2021 Feb 4;11(1):110
Translational psychiatry 2021 Feb 4;11(1):110
p53 induces ARTS to promote mitochondrial apoptosis.
Hao Q, Chen J, Liao J, Huang Y, Gan Y, Larisch S, Zeng SX, Lu H, Zhou X
Cell death & disease 2021 Feb 24;12(2):204
Cell death & disease 2021 Feb 24;12(2):204
Discovery of a novel AR/HDAC6 dual inhibitor for prostate cancer treatment.
Zhou M, Zheng H, Li Y, Huang H, Min X, Dai S, Zhou W, Chen Z, Xu G, Chen Y
Aging 2021 Feb 17;13(5):6982-6998
Aging 2021 Feb 17;13(5):6982-6998
Ginsenoside Rb1 protected PC12 cells from Aβ(25-35)-induced cytotoxicity via PPARγ activation and cholesterol reduction.
Changhong K, Peng Y, Yuan Z, Cai J
European journal of pharmacology 2021 Feb 15;893:173835
European journal of pharmacology 2021 Feb 15;893:173835
Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.
Otsu K, Ida-Yonemochi H, Ikezaki S, Ema M, Hitomi J, Ohshima H, Harada H
Development (Cambridge, England) 2021 Feb 15;148(4)
Development (Cambridge, England) 2021 Feb 15;148(4)
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Liu S, Chen L, Chen H, Xu K, Peng X, Zhang M
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
Journal of experimental & clinical cancer research : CR 2021 Feb 12;40(1):66
EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development.
Cao X, An J, Cao Y, Lv J, Wang J, Ding Y, Lin X, Zhou X
Investigative ophthalmology & visual science 2021 Feb 1;62(2):31
Investigative ophthalmology & visual science 2021 Feb 1;62(2):31
LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.
Wei WS, Wang N, Deng MH, Dong P, Liu JY, Xiang Z, Li XD, Li ZY, Liu ZH, Peng YL, Li Z, Jiang LJ, Yao K, Ye YL, Lu WH, Zhang ZL, Zhou FJ, Liu ZW, Xie D, Yu CP
Redox biology 2021 Dec;48:102201
Redox biology 2021 Dec;48:102201
Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication.
Du L, Xie Y, Zheng K, Wang N, Gao M, Yu T, Cao L, Shao Q, Zou Y, Xia W, Fang Q, Zhao B, Guo D, Peng X, Pan JA
Redox biology 2021 Dec;48:102199
Redox biology 2021 Dec;48:102199
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors.
Ibe NU, Subramanian A, Mukherjee S
Life science alliance 2021 Dec;4(12)
Life science alliance 2021 Dec;4(12)
UBQLN4 is an ATM substrate that stabilizes the anti-apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma.
Liu F, Pan R, Ding H, Gu L, Yang Y, Li C, Xu Y, Hu R, Chen H, Zhang X, Nie Y
Molecular oncology 2021 Dec;15(12):3738-3752
Molecular oncology 2021 Dec;15(12):3738-3752
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Li M, Lu H, Wang X, Duan C, Zhu X, Zhang Y, Ge X, Ji F, Wang X, Su J, Zhang D
Molecular immunology 2021 Dec;140:250-266
Molecular immunology 2021 Dec;140:250-266
CircSTK40 contributes to recurrent implantation failure via modulating the HSP90/AKT/FOXO1 axis.
Ni T, Zhang Q, Li Y, Huang C, Zhou T, Yan J, Chen ZJ
Molecular therapy. Nucleic acids 2021 Dec 3;26:208-221
Molecular therapy. Nucleic acids 2021 Dec 3;26:208-221
Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANA(SIM)-Associated Proteins in Hypoxia.
Liu X, Gan J, Du S, Zhu C, Wang Y, Jia Y, Zhang D, Qu D, Wei F, Robertson ES, Cai Q
mSystems 2021 Dec 21;6(6):e0110921
mSystems 2021 Dec 21;6(6):e0110921
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Zou Q, Yang L, Shi R, Qi Y, Zhang X, Qi H
iScience 2021 Dec 17;24(12):103396
iScience 2021 Dec 17;24(12):103396
Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions.
Krueger ES, Beales JL, Russon KB, Elison WS, Davis JR, Hansen JM, Neilson AP, Hansen JM, Tessem JS
Biomolecules 2021 Dec 17;11(12)
Biomolecules 2021 Dec 17;11(12)
Regulation of PDGFR-β gene expression by targeting the G-vacancy bearing G-quadruplex in promoter.
Chen JN, He YD, Liang HT, Cai TT, Chen Q, Zheng KW
Nucleic acids research 2021 Dec 16;49(22):12634-12643
Nucleic acids research 2021 Dec 16;49(22):12634-12643
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
Xu Y, Shi T, Cui X, Yan L, Wang Q, Xu X, Zhao Q, Xu X, Tang QQ, Tang H, Pan D
The EMBO journal 2021 Dec 15;40(24):e108069
The EMBO journal 2021 Dec 15;40(24):e108069
Cadmium exposure induces osteoporosis through cellular senescence, associated with activation of NF-κB pathway and mitochondrial dysfunction.
Luo H, Gu R, Ouyang H, Wang L, Shi S, Ji Y, Bao B, Liao G, Xu B
Environmental pollution (Barking, Essex : 1987) 2021 Dec 1;290:118043
Environmental pollution (Barking, Essex : 1987) 2021 Dec 1;290:118043
PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.
Yan L, Jin W, Zhao Q, Cui X, Shi T, Xu Y, Li F, Jin W, Zhang Z, Zhang Z, Tang QQ, Pan D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060
Proteomic analysis of the exosomes secreted from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus reveals their involvement in the cellular responses to viral infection.
Zhang X, Zhang Y, Pan J, Zhu M, Liang Z, Shen Z, Dai K, Yan B, Dai Y, Xue R, Cao G, Hu X, Gong C
Fish physiology and biochemistry 2021 Aug;47(4):857-867
Fish physiology and biochemistry 2021 Aug;47(4):857-867
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
He X, Gao F, Hou J, Li T, Tan J, Wang C, Liu X, Wang M, Liu H, Chen Y, Yu Z, Yang M
The Journal of biological chemistry 2021 Aug;297(2):101002
The Journal of biological chemistry 2021 Aug;297(2):101002
FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation.
Xu L, Xu W, Li D, Yu X, Gao F, Qin Y, Yang Y, Zhao S
Cell death & disease 2021 Aug 9;12(8):780
Cell death & disease 2021 Aug 9;12(8):780
Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1.
Jia H, Yang Y, Li M, Chu Y, Song H, Zhang J, Zhang D, Zhang Q, Xu Y, Wang J, Xu H, Zou X, Peng H, Hou Z
EMBO reports 2021 Aug 4;22(8):e51780
EMBO reports 2021 Aug 4;22(8):e51780
Identification of the Bcl-2 and Bax homologs from Rhipicephalus haemaphysaloides and their function in the degeneration of tick salivary glands.
Hu S, Wang Y, Xu Z, Zhou Y, Cao J, Zhang H, Zhou J
Parasites & vectors 2021 Aug 4;14(1):386
Parasites & vectors 2021 Aug 4;14(1):386
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I
eLife 2021 Aug 3;10
eLife 2021 Aug 3;10
ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.
Sun X, He Z, Guo L, Wang C, Lin C, Ye L, Wang X, Li Y, Yang M, Liu S, Hua X, Wen W, Lin C, Long Z, Zhang W, Li H, Jian Y, Zhu Z, Wu X, Lin H
Journal of experimental & clinical cancer research : CR 2021 Apr 30;40(1):149
Journal of experimental & clinical cancer research : CR 2021 Apr 30;40(1):149
Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy.
Xie S, Sun W, Zhang C, Dong B, Yang J, Hou M, Xiong L, Cai B, Liu X, Xue W
ACS nano 2021 Apr 27;15(4):7179-7194
ACS nano 2021 Apr 27;15(4):7179-7194
Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
Cai Y, Gu WT, Cheng K, Jia PF, Li F, Wang M, Zhang WF, Qiu JT, Wu ZB, Zhao WG
Biochemical and biophysical research communications 2021 Apr 23;550:134-141
Biochemical and biophysical research communications 2021 Apr 23;550:134-141
CK2 Activity Mediates the Aggressive Molecular Signature of Glioblastoma Multiforme by Inducing Nerve/Glial Antigen (NG)2 Expression.
Schmitt BM, Boewe AS, Götz C, Philipp SE, Urbschat S, Oertel J, Menger MD, Laschke MW, Ampofo E
Cancers 2021 Apr 2;13(7)
Cancers 2021 Apr 2;13(7)
Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9(+) cells to prevent the development of liver cancer in a mouse model.
Chen M, Lu C, Lu H, Zhang J, Qin D, Liu S, Li X, Zhang L
Stem cell research & therapy 2021 Apr 12;12(1):232
Stem cell research & therapy 2021 Apr 12;12(1):232
MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.
Wang X, Wen Y, Zhang J, Swanson G, Guo S, Cao C, Krawetz SA, Zhang Z, Yuan S
Development (Cambridge, England) 2021 Apr 1;148(7)
Development (Cambridge, England) 2021 Apr 1;148(7)
Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.
Jiang W, Ma P, Deng L, Liu Z, Wang X, Liu X, Long G
Journal of extracellular vesicles 2020;9(1):1716513
Journal of extracellular vesicles 2020;9(1):1716513
Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.
Zhang T, Li H, Wang K, Xu B, Chen ZN, Bian H
Frontiers in cell and developmental biology 2020;8:784
Frontiers in cell and developmental biology 2020;8:784
Oxytocin Alleviates MPTP-Induced Neurotoxicity in Mice by Targeting MicroRNA-26a/Death-Associated Protein Kinase 1 Pathway.
Almansoub HAMM, Tang H, Wu Y, Wang DQ, Mahaman YAR, Salissou MTM, Lu Y, Hu F, Zhou LT, Almansob YAM, Liu D
Journal of Alzheimer's disease : JAD 2020;74(3):883-901
Journal of Alzheimer's disease : JAD 2020;74(3):883-901
β-Actin facilitates etoposide-induced p53 nuclear import.
Qi W, Li J, Pei X, Ke Y, Bu Q, Ni X
Journal of biosciences 2020;45
Journal of biosciences 2020;45
Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway.
Zhang Z, Yu X, Zhou B, Zhang J, Chang J
BioMed research international 2020;2020:5103272
BioMed research international 2020;2020:5103272
Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.
Bu W, Hao X, Yang T, Wang J, Liu Q, Zhang X, Li X, Gong Y, Shao C
Oxidative medicine and cellular longevity 2020;2020:2015920
Oxidative medicine and cellular longevity 2020;2020:2015920
Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function.
Geng N, Wang X, Yu X, Wang R, Zhu Y, Zhang M, Liu J, Liu Y
Frontiers in immunology 2020;11:746
Frontiers in immunology 2020;11:746
Ubiquitin E3 Ligase c-Cbl Is a Host Negative Regulator of Nef Protein of HIV-1.
Zhang HG, Guo J, Yuan Y, Zuo Y, Liu J, Zhu L, Miao Y, Chen X, Jin L, Huang F, Ren T, He J, Shi W, Wen Z, Zhu C, Zheng H, Dong C, Qian F
Frontiers in microbiology 2020;11:597972
Frontiers in microbiology 2020;11:597972
Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction.
Wen W, Zhao Q, Yin M, Qin L, Hu J, Chen H, Li X, Qian P
Frontiers in immunology 2020;11:577838
Frontiers in immunology 2020;11:577838
Berberine Induces CYP2J2 Expression in Human U251 Glioma Cells via Regulation of Peroxisome Proliferator-Activated Receptor Alpha.
Yu X, Wang S, Wang J, Gong J, Shi J, Yu S
Pharmacology 2020;105(5-6):360-368
Pharmacology 2020;105(5-6):360-368
Precise and efficient silencing of mutant Kras(G12D) by CRISPR-CasRx controls pancreatic cancer progression.
Jiang W, Li H, Liu X, Zhang J, Zhang W, Li T, Liu L, Yu X
Theranostics 2020;10(25):11507-11519
Theranostics 2020;10(25):11507-11519
ITM2A as a Tumor Suppressor and Its Correlation With PD-L1 in Breast Cancer.
Zhang R, Xu T, Xia Y, Wang Z, Li X, Chen W
Frontiers in oncology 2020;10:581733
Frontiers in oncology 2020;10:581733
NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer.
Qin T, Cheng L, Xiao Y, Qian W, Li J, Wu Z, Wang Z, Xu Q, Duan W, Wong L, Wu E, Ma Q, Ma J
Frontiers in oncology 2020;10:1038
Frontiers in oncology 2020;10:1038
A role of cellular translation regulation associated with toxic Huntingtin protein.
Joag H, Ghatpande V, Desai M, Sarkar M, Raina A, Shinde M, Chitale R, Deo A, Bose T, Majumdar A
Cellular and molecular life sciences : CMLS 2020 Sep;77(18):3657-3670
Cellular and molecular life sciences : CMLS 2020 Sep;77(18):3657-3670
The protective effect of rosmarinic acid on myotube formation during myoblast differentiation under heat stress.
Chen KL, Wang Y, Lin ZP, Li HX
In vitro cellular & developmental biology. Animal 2020 Sep;56(8):635-641
In vitro cellular & developmental biology. Animal 2020 Sep;56(8):635-641
Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells.
Xu L, Wu T, Lu S, Hao X, Qin J, Wang J, Zhang X, Liu Q, Kong B, Gong Y, Liu Z, Shao C
Redox biology 2020 Sep;36:101604
Redox biology 2020 Sep;36:101604
SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells.
Dou J, Zhang H, Chen R, Shu Z, Yuan H, Zhao X, Wang Y, Huang J, Zhou A, Yu J
Molecular oncology 2020 Sep;14(9):2288-2312
Molecular oncology 2020 Sep;14(9):2288-2312
Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling.
Li SB, Liu YY, Yuan L, Ji MF, Zhang A, Li HY, Tang LQ, Fang SG, Zhang H, Xing S, Li MZ, Zhong Q, Lin SJ, Liu WL, Huang P, Zeng YX, Zheng YM, Ling ZQ, Sui JH, Zeng MS
EMBO molecular medicine 2020 Sep 7;12(9):e12050
EMBO molecular medicine 2020 Sep 7;12(9):e12050
A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
Maltby CJ, Schofield JPR, Houghton SD, O'Kelly I, Vargas-Caballero M, Deinhardt K, Coldwell MJ
Nucleic acids research 2020 Sep 25;48(17):9822-9839
Nucleic acids research 2020 Sep 25;48(17):9822-9839
Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1.
Qian G, Zhu L, Huang C, Liu Y, Ren Y, Ding Y, Qian W, Xu Q, Zheng H, Lv H
International immunopharmacology 2020 Oct;87:106763
International immunopharmacology 2020 Oct;87:106763
LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells.
Zhao X, Wang Y, He J, Deng R, Huang X, Guo Y, Li L, Xie R, Yu J
Molecular carcinogenesis 2020 Oct;59(10):1174-1187
Molecular carcinogenesis 2020 Oct;59(10):1174-1187
PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
Yong XLH, Cousin MA, Anggono V
Cell reports 2020 Oct 27;33(4):108312
Cell reports 2020 Oct 27;33(4):108312
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Ye C, Xiong W, Lei CT, Tang H, Su H, Yi F, Zhang C
American journal of physiology. Renal physiology 2020 Oct 1;319(4):F636-F646
American journal of physiology. Renal physiology 2020 Oct 1;319(4):F636-F646
Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase.
Zhong X, Ma Z, Su Y, Li Z, Liao Y, Pan X, Zang L, Zhou S
Life sciences 2020 Oct 1;258:118156
Life sciences 2020 Oct 1;258:118156
Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner.
Xu D, Liu L, Zhao Y, Yang L, Cheng J, Hua R, Zhang Z, Li Q
Journal of pineal research 2020 Nov;69(4):e12690
Journal of pineal research 2020 Nov;69(4):e12690
RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.
Zheng T, Zhou H, Li X, Peng D, Yang Y, Zeng Y, Liu H, Ren J, Zhao Y
Cell death and differentiation 2020 Nov;27(11):3162-3176
Cell death and differentiation 2020 Nov;27(11):3162-3176
MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency.
Zhang X, Dang Y, Liu R, Zhao S, Ma J, Qin Y
Journal of cellular physiology 2020 Nov;235(11):8826-8838
Journal of cellular physiology 2020 Nov;235(11):8826-8838
Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
Li XH, Chai RR, Chen GW, Zhang LF, Tan-Tai WJ, Shi HJ, Martin-DeLeon PA, O WS, Chen H
Asian journal of andrology 2020 Nov-Dec;22(6):583-589
Asian journal of andrology 2020 Nov-Dec;22(6):583-589
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Sun Z, Zhang Q, Yuan W, Li X, Chen C, Guo Y, Shao B, Dang Q, Zhou Q, Wang Q, Wang G, Liu J, Kan Q
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Nuclear import of NLS- RARα is mediated by importin α/β.
Ye J, Zhong L, Xiong L, Li J, Yu L, Dan W, Yuan Z, Yao J, Zhong P, Liu J, Liu D, Liu B
Cellular signalling 2020 May;69:109567
Cellular signalling 2020 May;69:109567
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.
Guerra J, Valadao AL, Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N
Science advances 2020 May;6(21):eaax3333
Science advances 2020 May;6(21):eaax3333
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.
Tang K, Li S, Li P, Xia Q, Yang R, Li T, Li L, Jiang Y, Qin X, Yang H, Wu C, You F, Tan Y, Liu Y
Biochimica et biophysica acta. Molecular cell research 2020 May;1867(5):118676
Biochimica et biophysica acta. Molecular cell research 2020 May;1867(5):118676
Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib.
Ke C, Hou H, Li J, Su K, Huang C, Lin Y, Lu Z, Du Z, Tan W, Yuan Z
Cancers 2020 May 4;12(5)
Cancers 2020 May 4;12(5)
Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress.
Zhang J, Duan H, Feng Z, Han X, Gu C
Oncogenesis 2020 May 12;9(5):46
Oncogenesis 2020 May 12;9(5):46
Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape.
Li Z, Wang J, Zhang X, Liu P, Zhang X, Wang J, Zheng X, Wei L, Peng Q, Liu C, Yan Q, Shen S, Li X, Ma J
Journal of immunology (Baltimore, Md. : 1950) 2020 May 1;204(9):2589-2599
Journal of immunology (Baltimore, Md. : 1950) 2020 May 1;204(9):2589-2599
A novel mutation in GPD1‑L associated with early repolarization syndrome via modulation of cardiomyocyte fast sodium currents.
Fan J, Ji CC, Cheng YJ, Yao H, Chen XM, Zheng ZH, Wu SH
International journal of molecular medicine 2020 Mar;45(3):947-955
International journal of molecular medicine 2020 Mar;45(3):947-955
Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.
Yuan Y, Miao Y, Zeng C, Liu J, Chen X, Qian L, Wang X, Qian F, Yu Z, Wang J, Qian G, Fu Q, Lv H, Zheng H
Immunology 2020 Mar;159(3):309-321
Immunology 2020 Mar;159(3):309-321
A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.
Liu DM, Cao ZX, Yan HL, Li W, Yang F, Zhao WJ, Diao QC, Tan YZ
Fitoterapia 2020 Mar;141:104484
Fitoterapia 2020 Mar;141:104484
FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells.
Park SY, Koh HC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111163
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Mar;137:111163
Development of a protein-based system for transient epigenetic repression of immune checkpoint molecule and enhancement of antitumour activity of natural killer cells.
Teratake Y, Takashina T, Iijima K, Sakuma T, Yamamoto T, Ishizaka Y
British journal of cancer 2020 Mar;122(6):823-834
British journal of cancer 2020 Mar;122(6):823-834
HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation.
Zhao JF, Rodger CE, Allen GFG, Weidlich S, Ganley IG
Cell stress 2020 Mar 4;4(5):99-113
Cell stress 2020 Mar 4;4(5):99-113
Structural basis for DEAH-helicase activation by G-patch proteins.
Studer MK, Ivanović L, Weber ME, Marti S, Jonas S
Proceedings of the National Academy of Sciences of the United States of America 2020 Mar 31;117(13):7159-7170
Proceedings of the National Academy of Sciences of the United States of America 2020 Mar 31;117(13):7159-7170
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Zuo Y, Feng Q, Jin L, Huang F, Miao Y, Liu J, Xu Y, Chen X, Zhang H, Guo T, Yuan Y, Zhang L, Wang J, Zheng H
Nature communications 2020 Mar 2;11(1):1146
Nature communications 2020 Mar 2;11(1):1146
Generation and Application of Mouse Monoclonal Antibody Against Human Cytomegalovirus UL23.
Li W, Chai H, Feng L, Deng J, Yang X, Ran Y, Li H
Viral immunology 2020 Jun;33(5):378-383
Viral immunology 2020 Jun;33(5):378-383
ChREBP-β regulates thermogenesis in brown adipose tissue.
Wei C, Ma X, Su K, Qi S, Zhu Y, Lin J, Wang C, Yang R, Chen X, Wang W, Zhang WJ
The Journal of endocrinology 2020 Jun;245(3):343-356
The Journal of endocrinology 2020 Jun;245(3):343-356
FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression.
Li YQ, Chen Y, Xu YF, He QM, Yang XJ, Li YQ, Hong XH, Huang SY, Tang LL, Liu N
Cancer science 2020 Jun;111(6):1991-2003
Cancer science 2020 Jun;111(6):1991-2003
Initiator and executioner caspases in salivary gland apoptosis of Rhipicephalus haemaphysaloides.
Wang Y, Hu S, Tuerdi M, Yu X, Zhang H, Zhou Y, Cao J, da Silva Vaz I Jr, Zhou J
Parasites & vectors 2020 Jun 5;13(1):288
Parasites & vectors 2020 Jun 5;13(1):288
RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling.
Ma P, An T, Zhu L, Zhang L, Wang H, Ren B, Sun B, Zhou X, Li Y, Mao B
Development (Cambridge, England) 2020 Jun 15;147(21)
Development (Cambridge, England) 2020 Jun 15;147(21)
M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT.
Huang GZ, Wu QQ, Zheng ZN, Shao TR, Chen YC, Zeng WS, Lv XZ
Aging 2020 Jun 11;12(12):11667-11684
Aging 2020 Jun 11;12(12):11667-11684
SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response.
Liu H, Xie S, Fang F, Kalvakolanu DV, Xiao W
Cell death & disease 2020 Jun 10;11(6):445
Cell death & disease 2020 Jun 10;11(6):445
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
Shim MS, Nettesheim A, Hirt J, Liton PB
Autophagy 2020 Jul;16(7):1248-1261
Autophagy 2020 Jul;16(7):1248-1261
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Sun X, Huang K, Haiming X, Lin Z, Yang Y, Zhang M, Liu P, Huang H
Clinical science (London, England : 1979) 2020 Jul 17;134(13):1573-1592
Clinical science (London, England : 1979) 2020 Jul 17;134(13):1573-1592
Alisma Shugan Decoction (ASD) Ameliorates Hepatotoxicity and Associated Liver Dysfunction by Inhibiting Oxidative Stress and p65/Nrf2/JunD Signaling Dysregulation In Vivo.
Sun Y, Pan H, Shen S, Xia Z, Yu Z, Li C, Sun P, Xin C
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 16;26:e921738
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 16;26:e921738
Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.
Slemmons KK, Yeung C, Baumgart JT, Juarez JOM, McCalla A, Helman LJ
Cancer research 2020 Jul 15;80(14):3046-3056
Cancer research 2020 Jul 15;80(14):3046-3056
Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation.
Tsai MH, Cheng HY, Nian FS, Liu C, Chao NH, Chiang KL, Chen SF, Tsai JW
Acta neuropathologica communications 2020 Jul 14;8(1):106
Acta neuropathologica communications 2020 Jul 14;8(1):106
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10
Immunity 2020 Jul 14;53(1):204-216.e10
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Su H, Ye C, Lei CT, Tang H, Zeng JY, Yi F, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.
Tang J, Zhang K, Dong J, Yan C, Hu C, Ji H, Chen L, Chen S, Zhao H, Song Z
Cell death and differentiation 2020 Jan;27(1):146-160
Cell death and differentiation 2020 Jan;27(1):146-160
Inhibition of the ATR-CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2.
Koppenhafer SL, Goss KL, Terry WW, Gordon DJ
Molecular cancer research : MCR 2020 Jan;18(1):91-104
Molecular cancer research : MCR 2020 Jan;18(1):91-104
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Liu J, Jin L, Chen X, Yuan Y, Zuo Y, Miao Y, Feng Q, Zhang H, Huang F, Guo T, Zhang L, Zhu L, Qian F, Zhu C, Zheng H
PLoS pathogens 2020 Jan;16(1):e1008215
PLoS pathogens 2020 Jan;16(1):e1008215
Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion.
Lee S, Park H, Zhu PP, Jung SY, Blackstone C, Chang J
Science signaling 2020 Jan 7;13(613)
Science signaling 2020 Jan 7;13(613)
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.
Yomtoubian S, Lee SB, Verma A, Izzo F, Markowitz G, Choi H, Cerchietti L, Vahdat L, Brown KA, Andreopoulou E, Elemento O, Chang J, Inghirami G, Gao D, Ryu S, Mittal V
Cell reports 2020 Jan 21;30(3):755-770.e6
Cell reports 2020 Jan 21;30(3):755-770.e6
High-brightness anterograde transneuronal HSV1 H129 tracer modified using a Trojan horse-like strategy.
Su P, Ying M, Han Z, Xia J, Jin S, Li Y, Wang H, Xu F
Molecular brain 2020 Jan 13;13(1):5
Molecular brain 2020 Jan 13;13(1):5
A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia.
Wang X, Wang Y, Li L, Xue X, Xie H, Shi H, Hu Y
Oncogene 2020 Feb;39(9):1860-1874
Oncogene 2020 Feb;39(9):1860-1874
Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway.
Ni R, Song G, Fu X, Song R, Li L, Pu W, Gao J, Hu J, Liu Q, He F, Zhang D, Huang G
Biomaterials 2020 Feb;232:119730
Biomaterials 2020 Feb;232:119730
Ibrutinib Potentiates Antihepatocarcinogenic Efficacy of Sorafenib by Targeting EGFR in Tumor Cells and BTK in Immune Cells in the Stroma.
Lin CH, Elkholy KH, Wani NA, Li D, Hu P, Barajas JM, Yu L, Zhang X, Jacob ST, Khan WN, Bai XF, Noonan AM, Ghoshal K
Molecular cancer therapeutics 2020 Feb;19(2):384-396
Molecular cancer therapeutics 2020 Feb;19(2):384-396
Murine Cytomegalovirus Protein pM49 Interacts with pM95 and Is Critical for Viral Late Gene Expression.
Han T, Hao H, Sleman SS, Xuan B, Tang S, Yue N, Qian Z
Journal of virology 2020 Feb 28;94(6)
Journal of virology 2020 Feb 28;94(6)
Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.
Yuan Y, Miao Y, Qian L, Zhang Y, Liu C, Liu J, Zuo Y, Feng Q, Guo T, Zhang L, Chen X, Jin L, Huang F, Zhang H, Zhang W, Li W, Xu G, Zheng H
Molecular cell 2020 Feb 20;77(4):734-747.e7
Molecular cell 2020 Feb 20;77(4):734-747.e7
Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1.
Hong X, Liu N, Liang Y, He Q, Yang X, Lei Y, Zhang P, Zhao Y, He S, Wang Y, Li J, Li Q, Ma J, Li Y
Molecular cancer 2020 Feb 15;19(1):33
Molecular cancer 2020 Feb 15;19(1):33
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Lin T, Luo W, Li Z, Zhang L, Zheng X, Mai L, Yang W, Guan G, Su Z, Liu P, Li Z, Xie Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity.
Zachari M, Longo M, Ganley IG
Life science alliance 2020 Dec;3(12)
Life science alliance 2020 Dec;3(12)
lncMGPF is a novel positive regulator of muscle growth and regeneration.
Lv W, Jin J, Xu Z, Luo H, Guo Y, Wang X, Wang S, Zhang J, Zuo H, Bai W, Peng Y, Tang J, Zhao S, Zuo B
Journal of cachexia, sarcopenia and muscle 2020 Dec;11(6):1723-1746
Journal of cachexia, sarcopenia and muscle 2020 Dec;11(6):1723-1746
GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation.
Zhou J, Tan Y, Zhang Y, Tong A, Shen X, Sun X, Jia D, Sun Q
Molecular biomedicine 2020 Dec 30;1(1):18
Molecular biomedicine 2020 Dec 30;1(1):18
DNA damage in human glomerular endothelial cells induces nodular glomerulosclerosis via an ATR and ANXA2 pathway.
Fujii A, Sunatani Y, Furuichi K, Fujimoto K, Adachi H, Iwabuchi K, Yokoyama H
Scientific reports 2020 Dec 17;10(1):22206
Scientific reports 2020 Dec 17;10(1):22206
USP39 Serves as a Deubiquitinase to Stabilize STAT1 and Sustains Type I IFN-Induced Antiviral Immunity.
Peng Y, Guo J, Sun T, Fu Y, Zheng H, Dong C, Xiong S
Journal of immunology (Baltimore, Md. : 1950) 2020 Dec 1;205(11):3167-3178
Journal of immunology (Baltimore, Md. : 1950) 2020 Dec 1;205(11):3167-3178
Downregulation of miR-146b-5p via iodine involvement repressed papillary thyroid carcinoma cell proliferation.
Pan Y, Yun W, Shi B, Cui R, Liu C, Ding Z, Fan J, Jiang W, Tang J, Zheng T, Yu X, Liu Y
Journal of molecular endocrinology 2020 Aug;65(2):1-10
Journal of molecular endocrinology 2020 Aug;65(2):1-10
Dual-engineered, "Trojanized" macrophages bio-modally eradicate tumors through biologically and photothermally deconstructing cancer cells in an on-demand, NIR-commanded, self-explosive manner.
Huang L, Yan W, Cai B, Song Y, Lv Q, Wang G, Wang L, Wang Z
Biomaterials 2020 Aug;250:120021
Biomaterials 2020 Aug;250:120021
ZMIZ1 promotes the proliferation and migration of melanocytes in vitiligo.
Li M, Fan Y, Wang Y, Xu J, Xu H
Experimental and therapeutic medicine 2020 Aug;20(2):1371-1378
Experimental and therapeutic medicine 2020 Aug;20(2):1371-1378
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Zhang C, Chen L, Peng D, Jiang A, He Y, Zeng Y, Xie C, Zhou H, Luo X, Liu H, Chen L, Ren J, Wang W, Zhao Y
Molecular cell 2020 Aug 6;79(3):425-442.e7
Molecular cell 2020 Aug 6;79(3):425-442.e7
Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD.
Li S, Wu Z, Li Y, Tantray I, De Stefani D, Mattarei A, Krishnan G, Gao FB, Vogel H, Lu B
Cell reports 2020 Aug 4;32(5):107989
Cell reports 2020 Aug 4;32(5):107989
GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice.
Guo S, Chunyu Lv, Ouyang S, Wang X, Liao A, Yuan S
Biochemical and biophysical research communications 2020 Aug 27;529(3):642-646
Biochemical and biophysical research communications 2020 Aug 27;529(3):642-646
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y, Deng Y, Zhang G, Chen Z, Chen Y, Liu T
Cell death & disease 2020 Aug 18;11(8):641
Cell death & disease 2020 Aug 18;11(8):641
Targeting PML in triple negative breast cancer elicits growth suppression and senescence.
Arreal L, Piva M, Fernández S, Revandkar A, Schaub-Clerigué A, Villanueva J, Zabala-Letona A, Pujana M, Astobiza I, Cortazar AR, Hermanova I, Bozal-Basterra L, Arruabarrena-Aristorena A, Crespo JR, Valcarcel-Jimenez L, Zúñiga-García P, Canals F, Torrano V, Barrio R, Sutherland JD, Alimonti A, Martin-Martin N, Carracedo A
Cell death and differentiation 2020 Apr;27(4):1186-1199
Cell death and differentiation 2020 Apr;27(4):1186-1199
Effects of peptidoglycan on the development of steatohepatitis.
Jin M, Lai Y, Zhao P, Shen Q, Su W, Yin Y, Zhang W
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Apr;1865(4):158595
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Apr;1865(4):158595
CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110.
Domínguez JM, Pérez-Chacón G, Guillén MJ, Muñoz-Alonso MJ, Somovilla-Crespo B, Cibrián D, Acosta-Iborra B, Adrados M, Muñoz-Calleja C, Cuevas C, Sánchez-Madrid F, Avilés P, Zapata JM
Journal of hematology & oncology 2020 Apr 7;13(1):32
Journal of hematology & oncology 2020 Apr 7;13(1):32
Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells.
Prieto-Garcia C, Hartmann O, Reissland M, Braun F, Fischer T, Walz S, Schülein-Völk C, Eilers U, Ade CP, Calzado MA, Orian A, Maric HM, Münch C, Rosenfeldt M, Eilers M, Diefenbacher ME
EMBO molecular medicine 2020 Apr 7;12(4):e11101
EMBO molecular medicine 2020 Apr 7;12(4):e11101
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Miyauchi Y, Kurita A, Yamashita R, Takamatsu T, Ikushiro S, Mackenzie PI, Tanaka Y, Ishii Y
Biochemical and biophysical research communications 2020 Apr 30;525(2):348-353
Biochemical and biophysical research communications 2020 Apr 30;525(2):348-353
Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis.
Aoudjehane L, Gautheron J, Le Goff W, Goumard C, Gilaizeau J, Nget CS, Savier E, Atif M, Lesnik P, Morichon R, Chrétien Y, Calmus Y, Scatton O, Housset C, Conti F
Disease models & mechanisms 2020 Apr 29;13(4)
Disease models & mechanisms 2020 Apr 29;13(4)
The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression.
Tang H, Chu Y, Huang Z, Cai J, Wang Z
Carcinogenesis 2020 Apr 22;41(2):182-193
Carcinogenesis 2020 Apr 22;41(2):182-193
Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos.
Chen M, Zhu Q, Li C, Kou X, Zhao Y, Li Y, Xu R, Yang L, Yang L, Gu L, Wang H, Liu X, Jiang C, Gao S
Nature communications 2020 Apr 14;11(1):1813
Nature communications 2020 Apr 14;11(1):1813
CACYBP Enhances Cytoplasmic Retention of P27(Kip1) to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.
Lian YF, Huang YL, Zhang YJ, Chen DM, Wang JL, Wei H, Bi YH, Jiang ZW, Li P, Chen MS, Huang YH
Theranostics 2019;9(26):8392-8408
Theranostics 2019;9(26):8392-8408
The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma.
Cheng F, Zhang P, Xiao Q, Li Y, Dong M, Wang H, Kuang D, He Y, Duan Q, Mao F, Wang B, Guo D
Frontiers in oncology 2019;9:447
Frontiers in oncology 2019;9:447
Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal Rats.
Liu N, Tong X, Huang W, Fu J, Xue X
BioMed research international 2019;2019:5249675
BioMed research international 2019;2019:5249675
Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome.
Chang HY, Cheng HY, Tsao AN, Liu C, Tsai JW
Frontiers in molecular neuroscience 2019;12:265
Frontiers in molecular neuroscience 2019;12:265
Phosphorylation of Microtubule- Associated Protein 4 Promotes Hypoxic Endothelial Cell Migration and Proliferation.
Zhang J, Li L, Zhang Q, Yang X, Zhang C, Zhang X, Zhang D, Lv Y, Song H, Chen B, Liu Y, Hu J, Huang Y
Frontiers in pharmacology 2019;10:368
Frontiers in pharmacology 2019;10:368
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Liu T, Li X, Wu M, Qin L, Chen H, Qian P
Frontiers in microbiology 2019;10:1202
Frontiers in microbiology 2019;10:1202
Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.
Nian FS, Li LL, Cheng CY, Wu PC, Lin YT, Tang CY, Ren BS, Tai CY, Fann MJ, Kao LS, Hong CJ, Tsai JW
Molecular neurobiology 2019 Sep;56(9):6095-6105
Molecular neurobiology 2019 Sep;56(9):6095-6105
Seneca Valley virus 2C and 3C inhibit type I interferon production by inducing the degradation of RIG-I.
Wen W, Yin M, Zhang H, Liu T, Chen H, Qian P, Hu J, Li X
Virology 2019 Sep;535:122-129
Virology 2019 Sep;535:122-129
Preparation and identification of polyclonal antibody against human cytomegalovirus encoding protein UL23.
Chai H, Wu S, Deng J, Feng L, Yang X, Ran Y, Li H
Protein expression and purification 2019 Sep;161:78-83
Protein expression and purification 2019 Sep;161:78-83
Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.
Dayebgadoh G, Sardiu ME, Florens L, Washburn MP
Journal of proteome research 2019 Sep 6;18(9):3479-3491
Journal of proteome research 2019 Sep 6;18(9):3479-3491
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
Martin-Hurtado A, Martin-Morales R, Robledinos-Antón N, Blanco R, Palacios-Blanco I, Lastres-Becker I, Cuadrado A, Garcia-Gonzalo FR
Scientific reports 2019 Sep 25;9(1):13896
Scientific reports 2019 Sep 25;9(1):13896
LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling.
Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y, Fan Z
The EMBO journal 2019 Sep 2;38(17):e101110
The EMBO journal 2019 Sep 2;38(17):e101110
Proteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1.
Sun L, Büeler H
Biochemical and biophysical research communications 2019 Sep 17;517(2):376-382
Biochemical and biophysical research communications 2019 Sep 17;517(2):376-382
SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes.
Xu D, Jiang X, He H, Liu D, Yang L, Chen H, Wu L, Geng G, Li Q
Life sciences 2019 Sep 1;232:116639
Life sciences 2019 Sep 1;232:116639
Vacuolar protein sorting 4 is required for silkworm metamorphosis.
Xia H, Chen L, Shao D, Liu X, Wang Q, Zhu F, Guo Z, Gao L, Chen K
Insect molecular biology 2019 Oct;28(5):728-738
Insect molecular biology 2019 Oct;28(5):728-738
Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage.
Buranasudja V, Doskey CM, Gibson AR, Wagner BA, Du J, Gordon DJ, Koppenhafer SL, Cullen JJ, Buettner GR
Molecular cancer research : MCR 2019 Oct;17(10):2102-2114
Molecular cancer research : MCR 2019 Oct;17(10):2102-2114
Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.
Li C, Chen W, Zheng L, Zhang B, Yang X, Zhang Q, Wang N, Wang Y, Yang J, Sha J, Zhou Z, Li X, Li Y, Shen XL
Toxicon : official journal of the International Society on Toxinology 2019 Oct;168:141-146
Toxicon : official journal of the International Society on Toxinology 2019 Oct;168:141-146
Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein.
Agback P, Dominguez F, Pustovalova Y, Lukash T, Shiliaev N, Orekhov VY, Frolov I, Agback T, Frolova EI
Virology 2019 Nov;537:130-142
Virology 2019 Nov;537:130-142
ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.
Guo T, Zuo Y, Qian L, Liu J, Yuan Y, Xu K, Miao Y, Feng Q, Chen X, Jin L, Zhang L, Dong C, Xiong S, Zheng H
Nature microbiology 2019 Nov;4(11):1872-1884
Nature microbiology 2019 Nov;4(11):1872-1884
PARP11 regulates total levels of type-I interferon receptor IFNAR1.
Guo T, Liu J, Chen X, Jin L, Huang F, Zheng H
Nature microbiology 2019 Nov;4(11):1771-1773
Nature microbiology 2019 Nov;4(11):1771-1773
Genomic Structure of Hstx2 Modifier of Prdm9-Dependent Hybrid Male Sterility in Mice.
Lustyk D, Kinský S, Ullrich KK, Yancoskie M, Kašíková L, Gergelits V, Sedlacek R, Chan YF, Odenthal-Hesse L, Forejt J, Jansa P
Genetics 2019 Nov;213(3):1047-1063
Genetics 2019 Nov;213(3):1047-1063
Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma.
Liu Y, Azizian NG, Dou Y, Pham LV, Li Y
Journal of hematology & oncology 2019 Nov 21;12(1):119
Journal of hematology & oncology 2019 Nov 21;12(1):119
ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade.
Tsai YT, Wu AC, Yang WB, Kao TJ, Chuang JY, Chang WC, Hsu TI
International journal of molecular sciences 2019 Nov 11;20(22)
International journal of molecular sciences 2019 Nov 11;20(22)
DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella.
Li Y, Sha Y, Wang X, Ding L, Liu W, Ji Z, Mei L, Huang X, Lin S, Kong S, Lu J, Qin W, Zhang X, Zhuang J, Tang Y, Lu Z
Clinical genetics 2019 May;95(5):590-600
Clinical genetics 2019 May;95(5):590-600
Glutamate affects the CYP1B1- and CYP2U1-mediated hydroxylation of arachidonic acid metabolism via astrocytic mGlu5 receptor.
Yu X, Wu J, Hu M, Wu J, Zhu Q, Yang Z, Xie X, Feng YQ, Yue J
The international journal of biochemistry & cell biology 2019 May;110:111-121
The international journal of biochemistry & cell biology 2019 May;110:111-121
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM
eLife 2019 May 28;8
eLife 2019 May 28;8
p53 suppression is essential for oncogenic SPAG5 upregulation in lung adenocarcinoma.
Wang T, Li K, Song H, Xu D, Liao Y, Jing B, Guo W, Hu M, Kuang Y, Sun B, Ling J, Zhang T, Xu J, Yao F, Deng J
Biochemical and biophysical research communications 2019 May 28;513(2):319-325
Biochemical and biophysical research communications 2019 May 28;513(2):319-325
Silver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication.
Wan C, Tai J, Zhang J, Guo Y, Zhu Q, Ling D, Gu F, Gan J, Zhu C, Wang Y, Liu S, Wei F, Cai Q
Cell death & disease 2019 May 21;10(6):392
Cell death & disease 2019 May 21;10(6):392
Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast.
Yukawa M, Okazaki M, Teratani Y, Furuta K, Toda T
Scientific reports 2019 May 14;9(1):7336
Scientific reports 2019 May 14;9(1):7336
Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.
Otsuka S, Sakakima H, Terashi T, Takada S, Nakanishi K, Kikuchi K
Brain structure & function 2019 Mar;224(2):727-738
Brain structure & function 2019 Mar;224(2):727-738
Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis.
Zhu Q, Ding L, Zi Z, Gao S, Wang C, Wang Y, Zhu C, Yuan Z, Wei F, Cai Q
Cell reports 2019 Mar 26;26(13):3657-3671.e5
Cell reports 2019 Mar 26;26(13):3657-3671.e5
SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation.
Xu D, Wu L, Jiang X, Yang L, Cheng J, Chen H, Hua R, Geng G, Yang L, Li Q
International journal of molecular sciences 2019 Mar 18;20(6)
International journal of molecular sciences 2019 Mar 18;20(6)
Embryonic morphology observation and HOXC8 gene expression in crest cushions of Chinese Crested duck.
Yuan X, Zheng S, Zhang Y, Guo Q, Wang S, Bi Y, Dai W, Shen X, Gu T, Pan R, Song Q, Wang Z, Zhang Y, Xu Q, Chang G, Chen G
Gene 2019 Mar 10;688:98-106
Gene 2019 Mar 10;688:98-106
Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.
Terashi T, Otsuka S, Takada S, Nakanishi K, Ueda K, Sumizono M, Kikuchi K, Sakakima H
Neurological research 2019 Jun;41(6):510-518
Neurological research 2019 Jun;41(6):510-518
Chromosome misalignment is associated with PLK1 activity at cenexin-positive mitotic centrosomes.
Colicino EG, Stevens K, Curtis E, Rathbun L, Bates M, Manikas J, Amack J, Freshour J, Hehnly H
Molecular biology of the cell 2019 Jun 15;30(13):1598-1609
Molecular biology of the cell 2019 Jun 15;30(13):1598-1609
Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.
Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S
Human molecular genetics 2019 Jun 1;28(11):1822-1836
Human molecular genetics 2019 Jun 1;28(11):1822-1836
Tranilast enhances the effect of anticancer agents in osteosarcoma.
Nakashima T, Nagano S, Setoguchi T, Sasaki H, Saitoh Y, Maeda S, Komiya S, Taniguchi N
Oncology reports 2019 Jul;42(1):176-188
Oncology reports 2019 Jul;42(1):176-188
WD40 repeat and FYVE domain containing 3 is essential for cardiac development.
Zhang S, Song Z, An L, Liu X, Hu XW, Naz A, Zhou R, Guo X, He L, Zhu H
Cardiovascular research 2019 Jul 1;115(8):1320-1331
Cardiovascular research 2019 Jul 1;115(8):1320-1331
Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, Forget A, Wang CH, Cigna SM, Lu IL, Chen WY, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW, Ayrault O
Developmental cell 2019 Jan 28;48(2):184-199.e5
Developmental cell 2019 Jan 28;48(2):184-199.e5
Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.
Han KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CW
Journal of cell science 2019 Jan 22;132(2)
Journal of cell science 2019 Jan 22;132(2)
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Kang H, Hong Z, Zhong M, Klomp J, Bayless KJ, Mehta D, Karginov AV, Hu G, Malik AB
American journal of physiology. Cell physiology 2019 Jan 1;316(1):C92-C103
American journal of physiology. Cell physiology 2019 Jan 1;316(1):C92-C103
Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis.
Zhang H, Wang Y, Dou J, Guo Y, He J, Li L, Liu X, Chen R, Deng R, Huang J, Xie R, Zhao X, Yu J
Oncogene 2019 Feb;38(9):1410-1431
Oncogene 2019 Feb;38(9):1410-1431
m(6)A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.
Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, Liu Q, Wang F, Wang Y, Wang X
Cell death & disease 2019 Feb 20;10(3):171
Cell death & disease 2019 Feb 20;10(3):171
NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury.
Xu D, Chen P, Wang B, Wang Y, Miao N, Yin F, Cheng Q, Zhou Z, Xie H, Zhou L, Liu J, Wang X, Zent R, Lu L, Zhang W
American journal of physiology. Renal physiology 2019 Feb 1;316(2):F382-F395
American journal of physiology. Renal physiology 2019 Feb 1;316(2):F382-F395
Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.
Woo Y, Kim SJ, Suh BK, Kwak Y, Jung HJ, Nhung TTM, Mun DJ, Hong JH, Noh SJ, Kim S, Lee A, Baek ST, Nguyen MD, Choe Y, Park SK
eLife 2019 Dec 9;8
eLife 2019 Dec 9;8
Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis.
Wang Y, Guo Y, Tang C, Han X, Xu M, Sun J, Zhao Y, Zhang Y, Wang M, Cao X, Zhu X, Guo W
Cell reports 2019 Dec 3;29(10):3101-3117.e7
Cell reports 2019 Dec 3;29(10):3101-3117.e7
Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.
Hanáková K, Bernatík O, Kravec M, Micka M, Kumar J, Harnoš J, Ovesná P, Paclíková P, Rádsetoulal M, Potěšil D, Tripsianes K, Čajánek L, Zdráhal Z, Bryja V
Cell communication and signaling : CCS 2019 Dec 23;17(1):170
Cell communication and signaling : CCS 2019 Dec 23;17(1):170
Dissecting the Role of DDX21 in Regulating Human Cytomegalovirus Replication.
Hao H, Han T, Xuan B, Sun Y, Tang S, Yue N, Qian Z
Journal of virology 2019 Dec 15;93(24)
Journal of virology 2019 Dec 15;93(24)
Loss of Rubicon ameliorates doxorubicin-induced cardiotoxicity through enhancement of mitochondrial quality.
Liu X, Zhang S, An L, Wu J, Hu X, Lai S, Mazhar H, Zou Y, He L, Zhu H
International journal of cardiology 2019 Dec 1;296:129-135
International journal of cardiology 2019 Dec 1;296:129-135
CXCL13/CXCR5 signaling contributes to diabetes-induced tactile allodynia via activating pERK, pSTAT3, pAKT pathways and pro-inflammatory cytokines production in the spinal cord of male mice.
Liu S, Liu X, Xiong H, Wang W, Liu Y, Yin L, Tu C, Wang H, Xiang X, Xu J, Duan B, Tao A, Zhao Z, Mei Z
Brain, behavior, and immunity 2019 Aug;80:711-724
Brain, behavior, and immunity 2019 Aug;80:711-724
TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ.
Lu H, Xiao J, Ke C, Ni X, Xiu R, Tian Q, Pan H, Zou L, Wang F, Ma T, Ji X, Yuan P, Liu L, Zhang J, Jia W, Duan Q, Zhu F
Cell death & disease 2019 Aug 5;10(8):583
Cell death & disease 2019 Aug 5;10(8):583
CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer.
Li H, Jin X, Liu B, Zhang P, Chen W, Li Q
BMC cancer 2019 Aug 22;19(1):826
BMC cancer 2019 Aug 22;19(1):826
Neferine in the Lotus Plumule Potentiates the Antitumor Effect of Imatinib in Primary Chronic Myeloid Leukemia Cells In Vitro.
Zhang Y, Xiao Y, Dong Q, Ouyang W, Qin Q
Journal of food science 2019 Apr;84(4):904-910
Journal of food science 2019 Apr;84(4):904-910
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.
Vauthier V, Ben Saad A, Elie J, Oumata N, Durand-Schneider AM, Bruneau A, Delaunay JL, Housset C, Aït-Slimane T, Meijer L, Falguières T
Scientific reports 2019 Apr 30;9(1):6653
Scientific reports 2019 Apr 30;9(1):6653
The Legionella effector RavD binds phosphatidylinositol-3-phosphate and helps suppress endolysosomal maturation of the Legionella-containing vacuole.
Pike CM, Boyer-Andersen R, Kinch LN, Caplan JL, Neunuebel MR
The Journal of biological chemistry 2019 Apr 19;294(16):6405-6415
The Journal of biological chemistry 2019 Apr 19;294(16):6405-6415
β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling.
Liu J, Yuan Y, Xu J, Xiao K, Xu Y, Guo T, Zhang L, Wang J, Zheng H
Frontiers in immunology 2018;9:2930
Frontiers in immunology 2018;9:2930
A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5(+) intestinal stem cell maintenance.
Li Y, Liu Y, Liu B, Wang J, Wei S, Qi Z, Wang S, Fu W, Chen YG
Cell discovery 2018;4:49
Cell discovery 2018;4:49
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
Tang Y, Huang W, Song Q, Zheng X, He R, Liu J
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
The Protective Role of Brain CYP2J in Parkinson's Disease Models.
Li Y, Wu J, Yu X, Na S, Li K, Yang Z, Xie X, Yang J, Yue J
Oxidative medicine and cellular longevity 2018;2018:2917981
Oxidative medicine and cellular longevity 2018;2018:2917981
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-κB signaling pathways in diabetic nephropathy.
Zhang M, Yan Z, Bu L, An C, Wang D, Liu X, Zhang J, Yang W, Deng B, Xie J, Zhang B
Drug design, development and therapy 2018;12:1255-1268
Drug design, development and therapy 2018;12:1255-1268
BCAT1 promotes proliferation of endometrial cancer cells through reprogrammed BCAA metabolism.
Wang P, Wu S, Zeng X, Zhang Y, Zhou Y, Su L, Lin W
International journal of clinical and experimental pathology 2018;11(12):5536-5546
International journal of clinical and experimental pathology 2018;11(12):5536-5546
Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity.
Chen YA, Lu IL, Tsai JW
Frontiers in molecular neuroscience 2018;11:422
Frontiers in molecular neuroscience 2018;11:422
Murine Cytomegalovirus Protein pM91 Interacts with pM79 and Is Critical for Viral Late Gene Expression.
Pan D, Han T, Tang S, Xu W, Bao Q, Sun Y, Xuan B, Qian Z
Journal of virology 2018 Sep 15;92(18)
Journal of virology 2018 Sep 15;92(18)
Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.
Mana-Capelli S, McCollum D
The Journal of biological chemistry 2018 Nov 23;293(47):18230-18241
The Journal of biological chemistry 2018 Nov 23;293(47):18230-18241
EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer.
Peng Q, Chen L, Wu W, Wang J, Zheng X, Chen Z, Jiang Q, Han J, Wei L, Wang L, Huang J, Ma J
Cell death & disease 2018 Nov 19;9(12):1146
Cell death & disease 2018 Nov 19;9(12):1146
UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment.
Yu Q, Zhang H, Li Y, Liu C, Wang S, Liao X
Molecular neurobiology 2018 May;55(5):3812-3821
Molecular neurobiology 2018 May;55(5):3812-3821
A Novel Cx50 Insert Mutation from a Chinese Congenital Cataract Family Impairs Its Cellular Membrane Localization and Function.
Cui X, Zhou Z, Zhu K, Feng R, Han J, Li M, Wang S, Li J, Zhang J, Jiang Q, Zhang W, Mu H, Liu Y, Hu Y
DNA and cell biology 2018 May;37(5):449-456
DNA and cell biology 2018 May;37(5):449-456
Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents.
Zhang L, Zhao Y, Wang J, Yang D, Zhao C, Wang C, Ma C, Cheng M
European journal of medicinal chemistry 2018 May 10;151:27-38
European journal of medicinal chemistry 2018 May 10;151:27-38
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration.
Jheng GW, Hur SS, Chang CM, Wu CC, Cheng JS, Lee HH, Chung BC, Wang YK, Lin KH, Del Álamo JC, Chien S, Tsai JW
Biochemical and biophysical research communications 2018 Mar 11;497(3):869-875
Biochemical and biophysical research communications 2018 Mar 11;497(3):869-875
Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes.
Chen Y, Qin X, An Q, Yi J, Feng F, Yin D, An N, Liu Z, Weng L, Chen S, Hu X, Yin W
EBioMedicine 2018 Jun;32:31-42
EBioMedicine 2018 Jun;32:31-42
Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation.
Dai W, Miller WP, Toro AL, Black AJ, Dierschke SK, Feehan RP, Kimball SR, Dennis MD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 19;32(12):fj201800413RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 19;32(12):fj201800413RR
Ifi27 is indispensable for mitochondrial function and browning in adipocytes.
Jin W, Jin W, Pan D
Biochemical and biophysical research communications 2018 Jun 18;501(1):273-279
Biochemical and biophysical research communications 2018 Jun 18;501(1):273-279
BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.
Zhu D, Osuka S, Zhang Z, Reichert ZR, Yang L, Kanemura Y, Jiang Y, You S, Zhang H, Devi NS, Bhattacharya D, Takano S, Gillespie GY, Macdonald T, Tan C, Nishikawa R, Nelson WG, Olson JJ, Van Meir EG
Cancer cell 2018 Jun 11;33(6):1004-1016.e5
Cancer cell 2018 Jun 11;33(6):1004-1016.e5
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy.
Wang D, Xiong M, Chen C, Du L, Liu Z, Shi Y, Zhang M, Gong J, Song X, Xiang R, Liu E, Tan X
Kidney international 2018 Jul;94(1):91-101
Kidney international 2018 Jul;94(1):91-101
AMPK/GSK3β/β-catenin cascade-triggered overexpression of CEMIP promotes migration and invasion in anoikis-resistant prostate cancer cells by enhancing metabolic reprogramming.
Zhang P, Song Y, Sun Y, Li X, Chen L, Yang L, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3924-3935
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3924-3935
Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.
Wang X, Wen Y, Dong J, Cao C, Yuan S
Proteomics 2018 Jul;18(14):e1700478
Proteomics 2018 Jul;18(14):e1700478
High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake.
Yen CH, Chang HS, Yang TH, Wang SF, Wu HC, Chen YC, Lin KJ, Wang S
International journal of molecular sciences 2018 Jul 22;19(7)
International journal of molecular sciences 2018 Jul 22;19(7)
ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3.
Feng Q, Miao Y, Ge J, Yuan Y, Zuo Y, Qian L, Liu J, Cheng Q, Guo T, Zhang L, Yu Z, Zheng H
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 15;201(2):675-687
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 15;201(2):675-687
MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6.
Dang Y, Wang X, Hao Y, Zhang X, Zhao S, Ma J, Qin Y, Chen ZJ
Cell death & disease 2018 Jan 24;9(2):106
Cell death & disease 2018 Jan 24;9(2):106
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Ji YX, Huang Z, Yang X, Wang X, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE, Li H
Nature medicine 2018 Feb;24(2):213-223
Nature medicine 2018 Feb;24(2):213-223
Low-dose paclitaxel downregulates MYC proto-oncogene bHLH transcription factor expression in colorectal carcinoma cells.
Li W, Zhu W, Lv C, Qu H, Xu K, Li H, Li H, Du Y, Liu G, Wang Y, Wei HJ, Zhao HY
Oncology letters 2018 Feb;15(2):1881-1887
Oncology letters 2018 Feb;15(2):1881-1887
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.
McWilliams TG, Prescott AR, Montava-Garriga L, Ball G, Singh F, Barini E, Muqit MMK, Brooks SP, Ganley IG
Cell metabolism 2018 Feb 6;27(2):439-449.e5
Cell metabolism 2018 Feb 6;27(2):439-449.e5
Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.
Huang Y, Wang H, Lian Y, Wu X, Zhou L, Wang J, Deng M, Huang Y
Cell death & disease 2018 Feb 2;9(2):141
Cell death & disease 2018 Feb 2;9(2):141
PMLIV overexpression promotes TGF-β-associated epithelial-mesenchymal transition and migration in MCF-7 cancer cells.
Liu Y, Wang JX, Huang D, Wang B, Li LL, Li XX, Ni P, Dong XL, Xia W, Yu CX, Xu WL, Chu WF, Zhao D
Journal of cellular physiology 2018 Dec;233(12):9575-9583
Journal of cellular physiology 2018 Dec;233(12):9575-9583
mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells.
Koppenhafer SL, Goss KL, Terry WW, Gordon DJ
Molecular cancer therapeutics 2018 Dec;17(12):2676-2688
Molecular cancer therapeutics 2018 Dec;17(12):2676-2688
Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia.
Hsiao CJ, Chang CH, Ibrahim RB, Lin IH, Wang CH, Wang WJ, Tsai JW
Journal of cell science 2018 Dec 17;131(24)
Journal of cell science 2018 Dec 17;131(24)
miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.
Chen C, Deng Y, Hu X, Ren H, Zhu J, Fu S, Xie J, Peng Y
Journal of physiology and biochemistry 2018 Aug;74(3):381-393
Journal of physiology and biochemistry 2018 Aug;74(3):381-393
Anillin is required for tumor growth and regulated by miR-15a/miR-16-1 in HBV-related hepatocellular carcinoma.
Lian YF, Huang YL, Wang JL, Deng MH, Xia TL, Zeng MS, Chen MS, Wang HB, Huang YH
Aging 2018 Aug 9;10(8):1884-1901
Aging 2018 Aug 9;10(8):1884-1901
RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
Kincaid RP, Lam VL, Chirayil RP, Randall G, Sullivan CS
Proceedings of the National Academy of Sciences of the United States of America 2018 Aug 7;115(32):8197-8202
Proceedings of the National Academy of Sciences of the United States of America 2018 Aug 7;115(32):8197-8202
Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.
Jiang D, Zou X, Zhang C, Chen J, Li Z, Wang Y, Deng Z, Wang L, Chen S
FEBS letters 2018 Apr;592(8):1400-1411
FEBS letters 2018 Apr;592(8):1400-1411
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
Pao KC, Wood NT, Knebel A, Rafie K, Stanley M, Mabbitt PD, Sundaramoorthy R, Hofmann K, van Aalten DMF, Virdee S
Nature 2018 Apr;556(7701):381-385
Nature 2018 Apr;556(7701):381-385
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Ma Y, Yuan S, Tian X, Lin S, Wei S, Hu T, Chen S, Li X, Chen S, Wu D, Wang M, Guo D
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
Qian G, Hu X, Li G, Ding Y, Zhu L, Zheng H, Li M, Li Z, Pan J, Li Y, Li G, Yang C, Liu Y, Xie Y, Lv H
Biochemical and biophysical research communications 2018 Apr 6;498(3):537-543
Biochemical and biophysical research communications 2018 Apr 6;498(3):537-543
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Quercetin attenuates AZT-induced neuroinflammation in the CNS.
Yang Y, Liu X, Wu T, Zhang W, Shu J, He Y, Tang SJ
Scientific reports 2018 Apr 18;8(1):6194
Scientific reports 2018 Apr 18;8(1):6194
MCPIP1 is a positive regulator of type I interferons antiviral activity.
Qian L, Zuo Y, Deng W, Miao Y, Liu J, Yuan Y, Guo T, Zhang L, Jin J, Wang J, Zheng H
Biochemical and biophysical research communications 2018 Apr 15;498(4):891-897
Biochemical and biophysical research communications 2018 Apr 15;498(4):891-897
CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis.
Shi WP, Ju D, Li H, Yuan L, Cui J, Luo D, Chen ZN, Bian H
International journal of molecular sciences 2018 Apr 10;19(4)
International journal of molecular sciences 2018 Apr 10;19(4)
Legionella Effector AnkX Disrupts Host Cell Endocytic Recycling in a Phosphocholination-Dependent Manner.
Allgood SC, Romero Dueñas BP, Noll RR, Pike C, Lein S, Neunuebel MR
Frontiers in cellular and infection microbiology 2017;7:397
Frontiers in cellular and infection microbiology 2017;7:397
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Zuo T, Zhu M, Xu W, Wang Z, Song H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(5):1855-1865
CMIP Promotes Proliferation and Metastasis in Human Glioma.
Wang B, Wu ZS, Wu Q
BioMed research international 2017;2017:5340160
BioMed research international 2017;2017:5340160
TGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling.
Wang JL, Qi Z, Li YH, Zhao HM, Chen YG, Fu W
Oncotarget 2017 Sep 19;8(41):70214-70225
Oncotarget 2017 Sep 19;8(41):70214-70225
MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors.
Ji HP, Xiong Y, Song WT, Zhang ED, Gao ZL, Yao F, Su T, Zhou RR, Xia XB
Scientific reports 2017 Sep 12;7(1):11374
Scientific reports 2017 Sep 12;7(1):11374
Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine.
Goss KL, Koppenhafer SL, Harmoney KM, Terry WW, Gordon DJ
Oncotarget 2017 Oct 20;8(50):87016-87032
Oncotarget 2017 Oct 20;8(50):87016-87032
SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis.
Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, Wang Y, Xu M, Jiang B, Yu J
Molecular cancer 2017 Oct 11;16(1):157
Molecular cancer 2017 Oct 11;16(1):157
IL-1β Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells.
Dang X, Zhu Q, He Y, Wang Y, Lu Y, Li X, Qi J, Wu H, Sun Y
Endocrinology 2017 Oct 1;158(10):3281-3291
Endocrinology 2017 Oct 1;158(10):3281-3291
MAPK/p38 regulation of cytoskeleton rearrangement accelerates induction of macrophage activation by TLR4, but not TLR3.
Bian H, Li F, Wang W, Zhao Q, Gao S, Ma J, Li X, Ren W, Qin C, Qi J
International journal of molecular medicine 2017 Nov;40(5):1495-1503
International journal of molecular medicine 2017 Nov;40(5):1495-1503
Hydrogen peroxide promotes the expression of angiopoietin like 4 in RAW264.7 macrophages via MAPK pathways.
Liu N, Cui C, Sun Y, Zhang F, Wang S, Su G, Cai X
Molecular medicine reports 2017 Nov;16(5):6128-6133
Molecular medicine reports 2017 Nov;16(5):6128-6133
Tectorigenin attenuates the MPP(+)-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition.
Gong P, Deng F, Zhang W, Ji J, Liu J, Sun Y, Hu J
Experimental and therapeutic medicine 2017 Nov;14(5):4431-4437
Experimental and therapeutic medicine 2017 Nov;14(5):4431-4437
HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
Shang Y, Chen H, Ye J, Wei X, Liu S, Wang R
Experimental cell research 2017 Nov 15;360(2):243-256
Experimental cell research 2017 Nov 15;360(2):243-256
Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats.
Bai Y, Wang Y, Liu M, Gu YH, Jiang B, Wu X, Wang HL
Molecular medicine reports 2017 May;15(5):3135-3142
Molecular medicine reports 2017 May;15(5):3135-3142
The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes.
de Castro RO, Previato L, Goitea V, Felberg A, Guiraldelli MF, Filiberti A, Pezza RJ
The Journal of biological chemistry 2017 May 19;292(20):8459-8471
The Journal of biological chemistry 2017 May 19;292(20):8459-8471
Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development.
Xia H, Shao D, Liu X, Wang Q, Zhou Y, Chen K
Journal of insect science (Online) 2017 May 1;17(3)
Journal of insect science (Online) 2017 May 1;17(3)
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.
Liu G, Zhou L, Zhang H, Chen R, Zhang Y, Li L, Lu JY, Jiang H, Liu D, Qi S, Jiang YM, Yin K, Xie Z, Shi Y, Liu Y, Cao X, Chen YX, Zou D, Zhang WJ
Nature communications 2017 Mar 22;8:14824
Nature communications 2017 Mar 22;8:14824
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.
Yu Z, Sun Y, She X, Wang Z, Chen S, Deng Z, Zhang Y, Liu Q, Liu Q, Zhao C, Li P, Liu C, Feng J, Fu H, Li G, Wu M
Journal of hematology & oncology 2017 Jun 8;10(1):115
Journal of hematology & oncology 2017 Jun 8;10(1):115
Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling.
Wu T, Zhang J, Geng M, Tang SJ, Zhang W, Shu J
Scientific reports 2017 Jun 23;7(1):4117
Scientific reports 2017 Jun 23;7(1):4117
Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Zhang C, Mao HL, Cao Y
Scientific reports 2017 Jun 19;7(1):3769
Scientific reports 2017 Jun 19;7(1):3769
Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.
Xie P, Yang JP, Cao Y, Peng LX, Zheng LS, Sun R, Meng DF, Wang MY, Mei Y, Qiang YY, Cao L, Xiang YQ, Luo DH, Yun JP, Huang BJ, Jia LJ, Qian CN
Cell death & disease 2017 Jun 1;8(6):e2834
Cell death & disease 2017 Jun 1;8(6):e2834
Mcl-1 suppresses abasic site repair following bile acid-induced hepatic cellular DNA damage.
Yu H, Zhang X, Liu R, Li H, Xiao X, Zhou Y, Wei C, Yang M, Liao M, Zhao J, Xia Z, Liao Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317712102
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317712102
A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation.
Pirone L, Xolalpa W, Sigurðsson JO, Ramirez J, Pérez C, González M, de Sabando AR, Elortza F, Rodriguez MS, Mayor U, Olsen JV, Barrio R, Sutherland JD
Scientific reports 2017 Jan 18;7:40756
Scientific reports 2017 Jan 18;7:40756
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Fan W, Liu T, Li X, Zhou Y, Wu M, Cui X, Chen H, Qian P
Molecular immunology 2017 Feb;82:114-122
Molecular immunology 2017 Feb;82:114-122
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
Wang Y, Gu YH, Liu M, Bai Y, Wang HL
Molecular medicine reports 2017 Feb;15(2):673-680
Molecular medicine reports 2017 Feb;15(2):673-680
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.
Nakano M, Tamura Y, Yamato M, Kume S, Eguchi A, Takata K, Watanabe Y, Kataoka Y
Scientific reports 2017 Feb 14;7:42041
Scientific reports 2017 Feb 14;7:42041
Antithrombin III prevents progression of chronic kidney disease following experimental ischaemic-reperfusion injury.
Yin J, Wang F, Kong Y, Wu R, Zhang G, Wang N, Wang L, Lu Z, Liang M
Journal of cellular and molecular medicine 2017 Dec;21(12):3506-3514
Journal of cellular and molecular medicine 2017 Dec;21(12):3506-3514
MDM2 is implicated in high-glucose-induced podocyte mitotic catastrophe via Notch1 signalling.
Tang H, Lei CT, Ye C, Gao P, Wan C, Chen S, He FF, Wang YM, Su H, Zhang C
Journal of cellular and molecular medicine 2017 Dec;21(12):3435-3444
Journal of cellular and molecular medicine 2017 Dec;21(12):3435-3444
Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription.
Cifuentes-Muñoz N, Branttie J, Slaughter KB, Dutch RE
Journal of virology 2017 Dec 15;91(24)
Journal of virology 2017 Dec 15;91(24)
De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.
Slavotinek A, Risolino M, Losa M, Cho MT, Monaghan KG, Schneidman-Duhovny D, Parisotto S, Herkert JC, Stegmann APA, Miller K, Shur N, Chui J, Muller E, DeBrosse S, Szot JO, Chapman G, Pachter NS, Winlaw DS, Mendelsohn BA, Dalton J, Sarafoglou K, Karachunski PI, Lewis JM, Pedro H, Dunwoodie SL, Selleri L, Shieh J
Human molecular genetics 2017 Dec 15;26(24):4849-4860
Human molecular genetics 2017 Dec 15;26(24):4849-4860
A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis.
Wang Z, Xia X, Yang X, Zhang X, Liu Y, Wu D, Fang Y, Liu Y, Xu J, Qiu Y, Zhou X
eLife 2017 Dec 12;6
eLife 2017 Dec 12;6
ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus.
Ma P, Ren B, Yang X, Sun B, Liu X, Kong Q, Li C, Mao B
Open biology 2017 Aug;7(8)
Open biology 2017 Aug;7(8)
Co-expression of podoplanin and fibroblast growth factor 1 predicts poor prognosis in patients with lung squamous cell carcinoma.
Li J, Chen H, Li X, Wang L, Gao A, Zhang P, Lin W, Gao W, Yang D, Guo X, Liu J, Dang Q, Sun Y
Molecular medicine reports 2017 Aug;16(2):1643-1652
Molecular medicine reports 2017 Aug;16(2):1643-1652
Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity by stabilizing type I-interferon receptor.
Zhao P, Guo T, Qian L, Wang X, Yuan Y, Cheng Q, Zuo Y, Liu J, Miao Y, Feng Q, Zhang L, Wu S, Zheng H
Antiviral research 2017 Aug;144:120-129
Antiviral research 2017 Aug;144:120-129
Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts.
Liu X, Zuo R, Bao Y, Qu X, Sun K, Ying H
Scientific reports 2017 Aug 16;7(1):8474
Scientific reports 2017 Aug 16;7(1):8474
HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.
Huang Q, Niu Z, Han J, Liu X, Lv Z, Li H, Yuan L, Li X, Sun S, Wang H, Huang X
Oncotarget 2017 Aug 1;8(31):51123-51133
Oncotarget 2017 Aug 1;8(31):51123-51133
Visualization of reticulophagy in living cells using an endoplasmic reticulum-targeted p62 mutant.
Wang L, Liu L, Qin L, Luo Q, Zhang Z
Science China. Life sciences 2017 Apr;60(4):333-344
Science China. Life sciences 2017 Apr;60(4):333-344
A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.
Tsai MH, Kuo PW, Myers CT, Li SW, Lin WC, Fu TY, Chang HY, Mefford HC, Chang YC, Tsai JW
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2016 Sep;20(5):788-94
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2016 Sep;20(5):788-94
Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.
El Najjar F, Cifuentes-Muñoz N, Chen J, Zhu H, Buchholz UJ, Moncman CL, Dutch RE
PLoS pathogens 2016 Sep;12(9):e1005922
PLoS pathogens 2016 Sep;12(9):e1005922
Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells.
Li Y, Liu YH, Hu YY, Chen L, Li JM
World journal of gastroenterology 2016 Oct 14;22(38):8528-8539
World journal of gastroenterology 2016 Oct 14;22(38):8528-8539
Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon.
Li L, Qian G, Zuo Y, Yuan Y, Cheng Q, Guo T, Liu J, Liu C, Zhang L, Zheng H
The Journal of biological chemistry 2016 Nov 25;291(48):24974-24985
The Journal of biological chemistry 2016 Nov 25;291(48):24974-24985
Suberoylanilide hydroxamic acid represses glioma stem-like cells.
Hsu CC, Chang WC, Hsu TI, Liu JJ, Yeh SH, Wang JY, Liou JP, Ko CY, Chang KY, Chuang JY
Journal of biomedical science 2016 Nov 18;23(1):81
Journal of biomedical science 2016 Nov 18;23(1):81
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death.
Fritsch J, Fickers R, Klawitter J, Särchen V, Zingler P, Adam D, Janssen O, Krause E, Schütze S
Oncotarget 2016 Nov 15;7(46):75774-75789
Oncotarget 2016 Nov 15;7(46):75774-75789
Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.
Qian G, Ren Y, Zuo Y, Yuan Y, Zhao P, Wang X, Cheng Q, Liu J, Zhang L, Guo T, Liu C, Zheng H
Biochemical and biophysical research communications 2016 Jun 3;474(3):491-496
Biochemical and biophysical research communications 2016 Jun 3;474(3):491-496
Small-Activating RNA Can Change Nucleosome Positioning in Human Fibroblasts.
Wang B, Sun J, Shi J, Guo Q, Tong X, Zhang J, Hu N, Hu Y
Journal of biomolecular screening 2016 Jul;21(6):634-42
Journal of biomolecular screening 2016 Jul;21(6):634-42
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S, Zheng H
PLoS pathogens 2016 Jul;12(7):e1005764
PLoS pathogens 2016 Jul;12(7):e1005764
Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring.
Park C, Lee SA, Hong JH, Suh Y, Park SJ, Suh BK, Woo Y, Choi J, Huh JW, Kim YM, Park SK
Molecular brain 2016 Jul 2;9(1):69
Molecular brain 2016 Jul 2;9(1):69
Influence of miR-30b regulating humoral immune response by genetic difference.
Duan ZQ, Shi JD, Wu MN, Hu NZ, Hu YZ
Immunologic research 2016 Feb;64(1):181-90
Immunologic research 2016 Feb;64(1):181-90
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
Kong YL, Shen Y, Ni J, Shao DC, Miao NJ, Xu JL, Zhou L, Xue H, Zhang W, Wang XX, Lu LM
Acta pharmacologica Sinica 2016 Feb;37(2):217-27
Acta pharmacologica Sinica 2016 Feb;37(2):217-27
Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.
Mukhopadhyay C, Triplett A, Bargar T, Heckman C, Wagner KU, Naramura M
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 20;113(51):E8228-E8237
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 20;113(51):E8228-E8237
State estimation and prediction using clustered particle filters.
Lee Y, Majda AJ
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 20;113(51):14609-14614
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 20;113(51):14609-14614
ERK-mediated NF-κB activation through ASIC1 in response to acidosis.
Chen B, Liu J, Ho TT, Ding X, Mo YY
Oncogenesis 2016 Dec 12;5(12):e279
Oncogenesis 2016 Dec 12;5(12):e279
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D
Nature chemical biology 2016 Apr;12(4):218-25
Nature chemical biology 2016 Apr;12(4):218-25
Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria.
Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F, He QY, Zhang G, Wang T
Journal of proteome research 2015 Sep 4;14(9):3645-57
Journal of proteome research 2015 Sep 4;14(9):3645-57
SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.
Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y, Yu J
Nucleic acids research 2015 Sep 18;43(16):7945-60
Nucleic acids research 2015 Sep 18;43(16):7945-60
Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.
Wang Z, Wu D, Liu Y, Xia X, Gong W, Qiu Y, Yang J, Zheng Y, Li J, Wang YF, Xiang Y, Hu Y, Zhou X
Science advances 2015 Oct;1(9):e1500228
Science advances 2015 Oct;1(9):e1500228
Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.
Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D, Li B, Qian Z
Journal of virology 2015 Mar;89(6):3049-61
Journal of virology 2015 Mar;89(6):3049-61
Increased stathmin expression strengthens fear conditioning in epileptic rats.
Zhang L, Feng D, Tao H, DE X, Chang Q, Hu Q
Biomedical reports 2015 Jan;3(1):28-32
Biomedical reports 2015 Jan;3(1):28-32
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Lu M, Wu J, He F, Wang XL, Li C, Chen ZN, Bian H
Journal of molecular histology 2015 Feb;46(1):79-91
Journal of molecular histology 2015 Feb;46(1):79-91
Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates.
Luccarini I, Grossi C, Rigacci S, Coppi E, Pugliese AM, Pantano D, la Marca G, Ed Dami T, Berti A, Stefani M, Casamenti F
Neurobiology of aging 2015 Feb;36(2):648-63
Neurobiology of aging 2015 Feb;36(2):648-63
Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats.
Li D, Wang X, Lan X, Li Y, Liu L, Yi J, Li J, Sun Q, Wang Y, Li H, Zhong N, Holmdahl R, Lu S
Molecular and cellular endocrinology 2015 Feb 15;402:1-12
Molecular and cellular endocrinology 2015 Feb 15;402:1-12
Analysis of grayscale characteristics in images of labeled microtubules from cultured cardiac myocytes.
Dang Y, Lan X, Zhang Q, Li L, Huang Y
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2015 Apr;21(2):334-42
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2015 Apr;21(2):334-42
TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.
Li X, Liu Y, Chen W, Fang Y, Xu H, Zhu HH, Chu M, Li W, Zhuang G, Gao WQ
Oncotarget 2014 Oct 15;5(19):9498-513
Oncotarget 2014 Oct 15;5(19):9498-513
Modulation of amylose content by structure-based modification of OsGBSS1 activity in rice (Oryza sativa L.).
Liu D, Wang W, Cai X
Plant biotechnology journal 2014 Dec;12(9):1297-307
Plant biotechnology journal 2014 Dec;12(9):1297-307
Axl receptor tyrosine kinase expression in breast cancer.
D'Alfonso TM, Hannah J, Chen Z, Liu Y, Zhou P, Shin SJ
Journal of clinical pathology 2014 Aug;67(8):690-6
Journal of clinical pathology 2014 Aug;67(8):690-6
lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.
Zhu M, Chen Q, Liu X, Sun Q, Zhao X, Deng R, Wang Y, Huang J, Xu M, Yan J, Yu J
The FEBS journal 2014 Aug;281(16):3766-75
The FEBS journal 2014 Aug;281(16):3766-75
INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity.
Yunlei Z, Zhe C, Yan L, Pengcheng W, Yanbo Z, Le S, Qianjin L
Molecular and cellular biochemistry 2013 Feb;374(1-2):81-9
Molecular and cellular biochemistry 2013 Feb;374(1-2):81-9
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Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The alpha Tubulin antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human alpha Tubulin. This antibody recognizes human,mouse,rat antigen. The alpha Tubulin antibody has been validated for the following applications: ELISA, IHC, IF, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Western blot of Hela cell with anti-Tubulin-Alpha (66031-1-Ig) at various dilutions.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TUBA1B antibody 66031-1-lg at 1:50 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 66031-1-Ig(Tubulin-Alpha antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 66031-1-Ig(Tubulin-Alpha antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
