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- Antibody Data
- Antigen structure
- References [187]
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- Product number
- HRP-66031 - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#HRP-66031, RRID:AB_2687491
- Product name
- alpha Tubulin antibody
- Antibody type
- Monoclonal
- Description
- Alpha Tubulin antibody (Cat. #HRP-66031) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Horseradish Peroxidase
- Isotype
- IgG
- Vial size
- 100ul
Submitted references Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy.
Integrated multi-platform metabolomics reveals fatty acid-mediated inflammatory signatures in pretibial myxedema.
High-salt diet aggravates skin inflammation of psoriasis-like mouse model with CCL20‒CCR6 axis further activation.
Mechanistic Insights Into Wnt/β-Catenin Pathway Modulation in Chronic Low Back Pain and Anxiety- and Depression-Related Behaviour in Male Sprague Dawley Rats.
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.
Cancer metabolism in radiation sensitization - complementary roles of O-GlcNAc transferase and PARP1.
Machine learning identifies key cells and therapeutic targets during ferroptosis after spinal cord injury.
PINCH-1-dependent regulation on tumor matrix microenvironment in pancreatic cancer.
Gypenoside L inhibits oral squamous cell carcinoma progression by targeting the AKT signaling pathway.
Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery.
Differential roles of the type I and II secretion systems for the intracellular ABC141 Acinetobacter baumannii infection, which elicits an atypical hypoxia response in endothelial cells.
Engineering a human-based translational activator for targeted protein expression restoration.
Target-stabilized base editors enable robust high-fidelity RNA editing.
The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity.
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development.
S-Adenosylmethionine Inhibits Plasminogen-Activating Inhibitor-1 and Protects Male Mice From FOLFOX-Induced Liver Injury.
Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention.
Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma.
Endogenous synthesis of n-3 PUFAs can reduce lipid synthesis in Fad3 transgenic cattle.
Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity.
ER-phagy Activation by AMFR Attenuates Cardiac Fibrosis Post-Myocardial Infarction via mTORC1 Pathway.
The CBS/H2S axis regulates intestinal stem cell homeostasis and radiation-induced intestinal damage.
TGFβ1-TNFα-regulated secretion of neutrophil chemokines is independent of epithelial-mesenchymal transition in breast tumor cells.
A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against Flaviviridae viruses by preventing endosomal acidification.
The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
Linker-free PROTACs efficiently induce the degradation of oncoproteins.
SMYD3 as an Epigenetic Regulator of Renal Tubular Cell Survival and Regeneration Following Acute Kidney Injury in Mice.
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism.
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis.
Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma.
Targeting FAK improves the tumor uptake of antibody-drug conjugates to strengthen the anti-cancer responses.
Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells.
Calcaratarin D, a labdane diterpenoid, attenuates bleomycin-induced pulmonary fibrosis by blocking Wnt/β-catenin signaling pathway.
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Activation of toll-like receptor 2 promotes the expression of inflammatory mediators and cell proliferation of human polycystic kidney disease cells.
Engineering a human-based translational activator for targeted protein expression restoration.
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling.
CDK6-Dependent, CDK4-Independent Synovial Hyperplasia in Arthritic Mice and Tumor Necrosis Factor-α-Induced Proliferation of Synovial Fibroblasts.
Tumor-Specific Antigen Delivery for T-cell Therapy via a pH-Sensitive Peptide Conjugate.
The inhibition of PINK1/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes.
Discovery of novel biaryl urea derivatives against IL-1β release with low toxicity based on NEK7 inhibitor.
Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression.
Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion.
Loss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation due to enhanced TNF-R1 surface expression and basal caspase-8 activation.
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression.
Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation.
Gemigliptin Alleviates Succinate Induced Endoplasmic Reticulum Stress and Activation of Hepatic Stellate Cells.
Targeted degradation of α-synuclein by arginine-based PROTACs.
LRBA deficiency impairs autophagy and contributes to enhanced antigen presentation and T-cell dysregulation.
PANCS-Binders: a rapid, high-throughput binder discovery platform.
Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD.
A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide.
Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice.
Natriuretic peptide receptor-C perturbs mitochondrial respiration in white adipose tissue.
Citrinin disrupts microtubule assembly in cardiac cells: Impact on mitochondrial organization and function.
Short Repeat Ribonucleic Acid Reduces Cytotoxicity by Preventing the Aggregation of TDP-43 and Its 25 KDa Carboxy-Terminal Fragment.
The effect of norepinephrine on ovarian dysfunction by mediating ferroptosis in mice model.
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice.
TGFβ1-TNFα regulated secretion of neutrophil chemokines is independent of epithelial-mesenchymal transitions in breast tumor cells.
Irilin D suppresses RANKL-induced osteoclastogenesis and prevents inflammation-induced bone loss by disrupting the NF-κB and MAPK signaling pathways.
Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.
Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.
Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways.
Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury.
Stress Granule Dysfunction via Chromophore-Associated Light Inactivation.
Foretinib Is Effective in Acute Myeloid Leukemia by Inhibiting FLT3 and Overcoming Secondary Mutations That Drive Resistance to Quizartinib and Gilteritinib.
Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity.
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia.
Light and classical music therapies attenuate chronic unpredictable mild stress-induced depression via BDNF signaling pathway in mice.
IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1.
The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis.
CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity.
Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition.
Design of antiviral AGO2-dependent short hairpin RNAs.
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC).
TGF-β1 activates neutrophil signaling and gene expression but not migration.
Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling.
Identification of VPS34-PI(3)P-FEN1-mediated DNA repair pathway as a potential drug target to overcome chemoresistance.
TCF12 Activates TGFB2 Expression to Promote the Malignant Progression of Melanoma.
KIAA1429/VIRMA promotes breast cancer progression by m(6) A-dependent cytosolic HAS2 stabilization.
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria.
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Alphavirus infection triggers antiviral RNAi immunity in mammals.
TGF-β1 activates neutrophil signaling and gene expression but not migration.
The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function.
The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genes.
BmCBP Catalyzes the Acetylation of BmApoLp-II Protein and Regulates Its Stability in Silkworm, Bombyx mori.
Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling.
Chemotherapeutic drugs-induced pyroptosis mediated by gasdermin E promotes the progression and chemoresistance of pancreatic cancer.
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo.
Brain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers.
ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality.
Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia.
Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling.
Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling.
The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation.
The MAD2B-APC/C-MDM2 axis mediates acute kidney injury by modulating p53.
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
Hedgehog receptors exert immune-surveillance roles in the epidermis across species.
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway.
FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
Branched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming.
PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex.
DUSP4 Inactivation Leads to Reduced Extracellular Signal‒Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells.
Retinal neurodegeneration in a mouse model of green-light-induced myopia.
Pharmacological Inhibition of Class III Alcohol Dehydrogenase 5: Turning Remote Ischemic Conditioning Effective in a Diabetic Stroke Model.
Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans.
Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.
Interference in melanoma CD248 function reduces vascular mimicry and metastasis.
Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis.
GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway.
Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice.
Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.
Transcription Factor ASCL1 Acts as a Novel Potential Therapeutic Target for the Treatment of the Cushing's Disease.
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis.
Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer.
Bombyx mori cypovirus (BmCPV) induces PINK1-Parkin mediated mitophagy via interaction of VP4 with host Tom40.
ZCL-082, a boron-containing compound, induces apoptosis of non-Hodgkin's lymphoma via targeting p90 ribosomal S6 kinase 1/NF-κB signaling pathway.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development.
From Initiation to Maintenance: HIV-1 Gp120-induced Neuropathic Pain Exhibits Different Molecular Mechanisms in the Mouse Spinal Cord Via Bioinformatics Analysis Based on RNA Sequencing.
TNFα activation and TGFβ blockage act synergistically for smooth muscle cell calcification in patients with venous thrombosis via TGFβ/ERK pathway.
Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation.
XBP1 variant 1 promotes mitosis of cancer cells involving upregulation of the polyglutamylase TTLL6.
ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells.
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration.
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes.
Cardioprotective Role of SIRT5 in Response to Acute Ischemia Through a Novel Liver-Cardiac Crosstalk Mechanism.
Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.
100 Hz Electroacupuncture Alleviated Chronic Itch and GRPR Expression Through Activation of Kappa Opioid Receptors in Spinal Dorsal Horn.
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.
FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression.
miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5.
Involvement of SIRT3-GSK3β deacetylation pathway in the effects of maternal diabetes on oocyte meiosis.
GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
PINCH-1 promotes Δ(1)-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma.
RAB27A-dependent release of exosomes by liver cancer stem cells induces Nanog expression in their differentiated progenies and confers regorafenib resistance.
LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway.
Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection.
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Mitochondrial dysfunction caused by novel ATAD3A mutations.
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
Wnt/β-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV(1) gp120-induced neuropathic pain.
PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.
Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria.
Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.
KLF9-dependent ROS regulate melanoma progression in stage-specific manner.
XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis.
Synergistic effect of arsenic trioxide, vismodegib and temozolomide on glioblastoma.
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14.
Bombyx mori cypovirus encoded small peptide inhibits viral multiplication.
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
The histone deacetylase inhibitor LBH589 inhibits undifferentiated pleomorphic sarcoma growth via downregulation of FOS-like antigen 1.
Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells.
Neurotensin receptor 1 is a new therapeutic target for human undifferentiated pleomorphic sarcoma growth.
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing.
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.
KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect.
[6]-Gingerol enhances the radiosensitivity of gastric cancer via G2/M phase arrest and apoptosis induction.
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-Cα by ubiquitin-proteasome system.
miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.
Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice.
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.
The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.
The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death.
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Wang P, Chen YH, Zhan ZT, Zeng JX, Chen Y, Lin Y, Chen T, Zhou WJ
Oncology research 2026;34(2):20
Oncology research 2026;34(2):20
Integrated multi-platform metabolomics reveals fatty acid-mediated inflammatory signatures in pretibial myxedema.
Cai J, Zhang L, Zheng J, Pan M, Li X, Zhao X, Wang S, Shang Z, Cao H, Chen X
Frontiers in endocrinology 2026;17:1734953
Frontiers in endocrinology 2026;17:1734953
High-salt diet aggravates skin inflammation of psoriasis-like mouse model with CCL20‒CCR6 axis further activation.
Hu M, Cao H, Zhang L, Xia Y, Zhang J, Xue F, Li X, Zheng J
JID innovations : skin science from molecules to population health 2026 Mar;6(2):100451
JID innovations : skin science from molecules to population health 2026 Mar;6(2):100451
Mechanistic Insights Into Wnt/β-Catenin Pathway Modulation in Chronic Low Back Pain and Anxiety- and Depression-Related Behaviour in Male Sprague Dawley Rats.
Xu J, Lin Y, Wu Z, Zhu Y, Jiang X, Jing L, Wang K, Zhang J
European journal of pain (London, England) 2026 Mar;30(3):e70245
European journal of pain (London, England) 2026 Mar;30(3):e70245
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.
Li J, Yang Y, Ge Y, Zhang X, Liu H, Chen Y, Yang Y, Wu Z
Autophagy 2026 Mar;22(3):445-467
Autophagy 2026 Mar;22(3):445-467
Cancer metabolism in radiation sensitization - complementary roles of O-GlcNAc transferase and PARP1.
Efimova E, Liu Y, Averbek S, Choi S, Ha S, Ricco N, Lomeli I, Viguls E, Kim WY, Kron SJ
Journal of cell science 2026 Mar 15;139(6)
Journal of cell science 2026 Mar 15;139(6)
Machine learning identifies key cells and therapeutic targets during ferroptosis after spinal cord injury.
Lv Y, Li Z, Shi L, Jian H, Yang F, Qiu J, Li C, Xiao P, Ruan W, Li H, Li X, Feng S, Zhou H
Neural regeneration research 2026 Jun 1;21(6):2495-2505
Neural regeneration research 2026 Jun 1;21(6):2495-2505
PINCH-1-dependent regulation on tumor matrix microenvironment in pancreatic cancer.
Wang R, Yang X, Wong YH, Guo L, Wu C, Chan BP
Biomaterials 2026 Jul;330:124074
Biomaterials 2026 Jul;330:124074
Gypenoside L inhibits oral squamous cell carcinoma progression by targeting the AKT signaling pathway.
Lai DY, Chen Y, Lan T, Zheng DL, Lu YG, Gan RH
Bioorganic chemistry 2026 Jan;168:109303
Bioorganic chemistry 2026 Jan;168:109303
Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery.
Fletcher CT, Mornement AA, Barrett C, Canning P, Rucktooa P, Huber S, Cooper CDO, Scully CCG, Doré AS, Rohle D, Smith GMT, Skerratt SE, Kennedy AJ
Communications biology 2026 Jan 28;9(1)
Communications biology 2026 Jan 28;9(1)
Differential roles of the type I and II secretion systems for the intracellular ABC141 Acinetobacter baumannii infection, which elicits an atypical hypoxia response in endothelial cells.
Debruyne C, Hodge L, Hokamp K, Ershova AS, Kröger C, Salcedo SP
PLoS pathogens 2026 Feb;22(2):e1013265
PLoS pathogens 2026 Feb;22(2):e1013265
Engineering a human-based translational activator for targeted protein expression restoration.
Sinnott RW, Solanki A, Govind AP, Green WN, Dickinson BC
Nucleic acids research 2026 Feb 5;54(4)
Nucleic acids research 2026 Feb 5;54(4)
Target-stabilized base editors enable robust high-fidelity RNA editing.
Liu T, Lin Y, Liu Q, Liao W, Lin Y, Zhang Y, Zhang J, Cao W, Yang L, Hong Z, Lu Z
Nature communications 2026 Feb 25;17(1)
Nature communications 2026 Feb 25;17(1)
The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity.
Tong M, Chen Y, Song B, Hong J, Gu W, Shen J, Yang H, Xia H, Li Q, Chen Y, Zhao S, Lyu Q, Xue W, Ma Q, Zhou H, Wu H, Guo Y, Cao Z, Zhao Y, Zhang M, Gu X, Zheng J, Zhang Y, Lu J, Ning G, Bi Y, Wang W, Liu R, Wang J
Science translational medicine 2026 Feb 11;18(836):eadw0458
Science translational medicine 2026 Feb 11;18(836):eadw0458
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
Li H, Zhao R, Wan L, Yuan Y, Ma E, Li Y, Chen Z, Liu B, Song Y, Cao Z, Jiao X, Wang Y, Wu P, Jin H, Li J, Yang X, Huang L, Zhang Y, Yang K, Huo J, Jin H, Zhong H, Min M, Zhang S, Cao Y, Li W, Zhang R, Wei C
Nature aging 2026 Apr 6;
Nature aging 2026 Apr 6;
Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development.
Wei T, Lin R, Lu Y, Jin DY, Zhang J, Sham MH
International journal of biological sciences 2025;21(3):1081-1096
International journal of biological sciences 2025;21(3):1081-1096
S-Adenosylmethionine Inhibits Plasminogen-Activating Inhibitor-1 and Protects Male Mice From FOLFOX-Induced Liver Injury.
Gangi A, Li TWH, Lim Y, Chandla S, Floris A, Khangholi A, Tomasi ML, Lu SC
Cellular and molecular gastroenterology and hepatology 2025;19(8):101513
Cellular and molecular gastroenterology and hepatology 2025;19(8):101513
Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention.
Zhou X, Yu H, Wang Y, Chen K, Shen X
Frontiers in aging neuroscience 2025;17:1662732
Frontiers in aging neuroscience 2025;17:1662732
Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma.
Yang Y, Wang F, Zhang Y, Huang R, Zhang C, Zhao L, Dang H, Tao X, Lu Y, Lu D, Zhang Y, He K, Weng J, Chen Z, Wang Z, Yu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02271
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02271
Endogenous synthesis of n-3 PUFAs can reduce lipid synthesis in Fad3 transgenic cattle.
Li D, Gao Y, Zhao X, Yun Y, Bo C, Song L, Yang L, Bai C, Li G, Su G
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159672
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159672
Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity.
Jiang T, Jing S, Li H, Xiao B, Jin J, Sun X, Wang J, Liang J, Cai T, Hu H, Wei M, Zhong X, Ji Y, Wang PG, Zhou J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e17205
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e17205
ER-phagy Activation by AMFR Attenuates Cardiac Fibrosis Post-Myocardial Infarction via mTORC1 Pathway.
Wang Z, Niu K, Liu W, Wang X, Yang B, Li T, Chen Y, Jin Y, Chen Y, Lin Y, Jin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e04552
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e04552
The CBS/H2S axis regulates intestinal stem cell homeostasis and radiation-induced intestinal damage.
Wu T, Zheng Z, Ren J, Yang Z, Zhang N, Guo K, Chen D, Gao M, Chen Y, Liang X, Wang Y, Chen W, Su Y, He J, Wang F
Stem cell research & therapy 2025 Oct 31;16(1):603
Stem cell research & therapy 2025 Oct 31;16(1):603
TGFβ1-TNFα-regulated secretion of neutrophil chemokines is independent of epithelial-mesenchymal transition in breast tumor cells.
SenGupta S, Cohen E, Serrenho J, Ott K, Coulombe PA, Parent CA
Molecular biology of the cell 2025 Oct 1;36(10):ar122
Molecular biology of the cell 2025 Oct 1;36(10):ar122
A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against Flaviviridae viruses by preventing endosomal acidification.
Chen G, Li W, Lam KH, Hu M, Wu Q, Xu X, Huang Y, Tang F, Cui G, Cui P, Zuo J, Liu L, Qian J, Zhang H-J, Li Y-P
Antimicrobial agents and chemotherapy 2025 Nov 5;69(11):e0052725
Antimicrobial agents and chemotherapy 2025 Nov 5;69(11):e0052725
The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
Chen J, Xu W, Meng L, Zhang X, Lin M, Zhang S, Liu Y, Guo F
Journal of cellular and molecular medicine 2025 May;29(10):e70616
Journal of cellular and molecular medicine 2025 May;29(10):e70616
Linker-free PROTACs efficiently induce the degradation of oncoproteins.
Zhang J, Chen C, Chen X, Liao K, Li F, Song X, Liu C, Su MY, Sun H, Hou T, Tan CSH, Fang L, Rao H
Nature communications 2025 May 23;16(1):4794
Nature communications 2025 May 23;16(1):4794
SMYD3 as an Epigenetic Regulator of Renal Tubular Cell Survival and Regeneration Following Acute Kidney Injury in Mice.
Du X, Shen F, Yu C, Wang Y, Yu J, Yao L, Liu N, Zhuang S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70533
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70533
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism.
Zhang Z, Zheng L, Chen Y, Chen Y, Hou J, Xiao C, Zhu X, Zhao SM, Xiong JW
eLife 2025 May 15;13
eLife 2025 May 15;13
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis.
Sheng X, Jin L, Yao Z, Gu J, Zhu L, Huang A, Peng J, Xu X, Ge X, Zhou W, Sheng J, Xu Z, Bai R
Cell discovery 2025 May 13;11(1):46
Cell discovery 2025 May 13;11(1):46
Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma.
Han Z, Yan Z, Ma Z, Wang Y, Beus M, Lu J, Weidenhammer LB, Lakhani K, Lee J, Civils JD, Furdui CM, Liu L, Wu J, Kang Y, Bieberich E, Boise LH, Nikiforov MA
Leukemia 2025 Mar;39(3):720-733
Leukemia 2025 Mar;39(3):720-733
Targeting FAK improves the tumor uptake of antibody-drug conjugates to strengthen the anti-cancer responses.
Zhang B, Zhang Z, Gao J, Lu S, Pang R, Li D, Huang X, Qin N, Liu L, Wang Z
iScience 2025 Mar 21;28(3):111536
iScience 2025 Mar 21;28(3):111536
Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells.
Wen B, Zheng HX, Heng JH, Tang Q, Deng DX, Zhang ZD, Liao LD, Xu LY, Li EM
Cell death & disease 2025 Mar 1;16(1):147
Cell death & disease 2025 Mar 1;16(1):147
Calcaratarin D, a labdane diterpenoid, attenuates bleomycin-induced pulmonary fibrosis by blocking Wnt/β-catenin signaling pathway.
Liao W, Ang Y, Kee ACL, Lim V, Lim AYH, Chai CLL, Wong WSF
Pharmacological research 2025 Jun;216:107756
Pharmacological research 2025 Jun;216:107756
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Chen Y, Yan Q, Ruan S, Cui J, Li Z, Zhang Z, Yang J, Fang J, Liu S, Huang S, Hou B, Zhang C
Cell reports 2025 Jun 24;44(6):115774
Cell reports 2025 Jun 24;44(6):115774
Activation of toll-like receptor 2 promotes the expression of inflammatory mediators and cell proliferation of human polycystic kidney disease cells.
Zhang Y, Plansinis M, Peak S, Weber E, Wei A, Xu Y, Ross M, Leagjeld A, Wallace DP, Zhang Y
Cellular signalling 2025 Jul;131:111749
Cellular signalling 2025 Jul;131:111749
Engineering a human-based translational activator for targeted protein expression restoration.
Sinnott RW, Solanki A, Govind AP, Green WN, Dickinson BC
bioRxiv : the preprint server for biology 2025 Jul 9;
bioRxiv : the preprint server for biology 2025 Jul 9;
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
Sinha IR, Sandal PS, Spence H, Burns GD, Mallika AP, Abbasinejad F, Irwin KE, Cruz ALF, Wang V, Marx SR, Rodríguez JL, Langmead B, Gregory JM, Wong PC, Ling JP
Nature communications 2025 Jul 25;16(1):6878
Nature communications 2025 Jul 25;16(1):6878
The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling.
Xia F, Zhang Z, Qian Z, Fang X, Wang J, Wang Y, Sun G, Yu Y, Wang N, Zhen J, Liu Y, Lu Y
Molecular metabolism 2025 Jan;91:102069
Molecular metabolism 2025 Jan;91:102069
CDK6-Dependent, CDK4-Independent Synovial Hyperplasia in Arthritic Mice and Tumor Necrosis Factor-α-Induced Proliferation of Synovial Fibroblasts.
Komatsu R, Fujii R, Ogasawara T, Suzuki-Takahashi Y, Chen S, Sugishita Y, Niki H, Yudoh K
International journal of molecular sciences 2025 Jan 28;26(3)
International journal of molecular sciences 2025 Jan 28;26(3)
Tumor-Specific Antigen Delivery for T-cell Therapy via a pH-Sensitive Peptide Conjugate.
Yurkevicz AM, Liu Y, Katz SG, Glazer PM
Molecular cancer therapeutics 2025 Jan 2;24(1):105-117
Molecular cancer therapeutics 2025 Jan 2;24(1):105-117
The inhibition of PINK1/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes.
Chen XJ, Yang YY, Pan ZC, Xu JZ, Jiang T, Zhang LL, Zhu KC, Zhang D, Song JX, Sheng CX, Sun LH, Tao B, Liu JM, Zhao HY
iScience 2025 Jan 17;28(1):111519
iScience 2025 Jan 17;28(1):111519
Discovery of novel biaryl urea derivatives against IL-1β release with low toxicity based on NEK7 inhibitor.
Wang L, Zhu K, Tian Z, Wang H, Jia Y, Feng C, Qi L, Tang W, Hu Y
European journal of medicinal chemistry 2025 Feb 5;283:117125
European journal of medicinal chemistry 2025 Feb 5;283:117125
Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression.
Cao YF, Wang H, Sun Y, Tong BB, Shi WQ, Peng L, Zhang YM, Wu YQ, Fu T, Zou HY, Zhang K, Xu LY, Li EM
Nature communications 2025 Feb 2;16(1):1271
Nature communications 2025 Feb 2;16(1):1271
Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion.
Okura T, Nakai Y, Kameya T, Mizukoshi F, Okura H, Kakizaki M, Kato F, Matsumoto Y, Nakatsu Y, Takeuchi K, Kimura H, Takeda M, Otsuki N, Shirato K, Hasegawa H, Ryo A
PLoS pathogens 2025 Dec;21(12):e1013755
PLoS pathogens 2025 Dec;21(12):e1013755
Loss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation due to enhanced TNF-R1 surface expression and basal caspase-8 activation.
Braun S, Knackfuß K, Ziesmann T, Mlinzk L, Goerg A, Frankenheim J, Walter A, Schneider-Brachert W, Distler U, Fritsch J
Cell communication and signaling : CCS 2025 Dec 4;23(1):520
Cell communication and signaling : CCS 2025 Dec 4;23(1):520
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression.
Li C, Lu Y, Li Y, Liu T, Deng H, Gao M, Zhou B, Liu J, Cai J, Huang D, Yang L, Jin J, Kuang D, Su S
Cell metabolism 2025 Dec 2;37(12):2402-2422.e18
Cell metabolism 2025 Dec 2;37(12):2402-2422.e18
Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation.
Wang S, Li W, Wen J, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
mBio 2025 Dec 10;16(12):e0293025
mBio 2025 Dec 10;16(12):e0293025
Gemigliptin Alleviates Succinate Induced Endoplasmic Reticulum Stress and Activation of Hepatic Stellate Cells.
Do DV, Nguyen G, Park SY, Cho EH
Journal of Korean medical science 2025 Dec 1;40(46):e304
Journal of Korean medical science 2025 Dec 1;40(46):e304
Targeted degradation of α-synuclein by arginine-based PROTACs.
Shen L, Zhang J, Wang Z, Liu Y, Cui S, Rao H
The Journal of biological chemistry 2025 Aug;301(8):110449
The Journal of biological chemistry 2025 Aug;301(8):110449
LRBA deficiency impairs autophagy and contributes to enhanced antigen presentation and T-cell dysregulation.
Sindram E, Deau MC, Ligeon LA, Sanchez-Martin P, Nestel S, Jung S, Ruf S, Mishra P, Proietti M, Günther S, Thedieck K, Roussa E, Rambold A, Münz C, Kraft C, Grimbacher B, Gámez-Díaz L
EMBO reports 2025 Aug;26(16):4040-4071
EMBO reports 2025 Aug;26(16):4040-4071
PANCS-Binders: a rapid, high-throughput binder discovery platform.
Styles MJ, Pixley JA, Wei T, Basile C, Lu SS, Dickinson BC
Nature methods 2025 Aug;22(8):1720-1730
Nature methods 2025 Aug;22(8):1720-1730
Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD.
Zhang F, Yue K, Sun S, Lu S, Jia G, Zha Y, Zhang S, Chou CJ, Liao C, Li X, Duan Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412903
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412903
A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide.
Wang Z, Ojogun N, Liu Y, Gan L, Xiao Z, Feng J, Jiang W, Chen Y, Zou B, Yu C, Li C, Ashuo A, Li X, Fu M, Wu J, Chu Y, Munford RS, Lu M
eLife 2025 Apr 24;13
eLife 2025 Apr 24;13
Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice.
Jiang C, Lao G, Ran J, Zhu P
Experimental biology and medicine (Maywood, N.J.) 2024;249:10280
Experimental biology and medicine (Maywood, N.J.) 2024;249:10280
Natriuretic peptide receptor-C perturbs mitochondrial respiration in white adipose tissue.
Li SJ, Wei JQ, Kang YY, Wang RQ, Rong WW, Zhao JJ, Deng QW, Gao PJ, Li XD, Wang JG
Journal of lipid research 2024 Sep;65(9):100623
Journal of lipid research 2024 Sep;65(9):100623
Citrinin disrupts microtubule assembly in cardiac cells: Impact on mitochondrial organization and function.
Tsai JF, Yu FY, Liu BH
Chemosphere 2024 Oct;365:143352
Chemosphere 2024 Oct;365:143352
Short Repeat Ribonucleic Acid Reduces Cytotoxicity by Preventing the Aggregation of TDP-43 and Its 25 KDa Carboxy-Terminal Fragment.
Fujimoto A, Kinjo M, Kitamura A
JACS Au 2024 Oct 28;4(10):3896-3909
JACS Au 2024 Oct 28;4(10):3896-3909
The effect of norepinephrine on ovarian dysfunction by mediating ferroptosis in mice model.
Hong H, Xiao C, Weng L, Wang Q, Lai D
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):542-553
Acta biochimica et biophysica Sinica 2024 Oct 22;57(4):542-553
Effects of Electroacupuncture at Varied Frequencies on Analgesia and Mechanisms in Sciatic Nerve Cuffing-Induced Neuropathic Pain Mice.
Fang K, Cheng W, Yu B
Journal of molecular neuroscience : MN 2024 Oct 17;74(4):98
Journal of molecular neuroscience : MN 2024 Oct 17;74(4):98
TGFβ1-TNFα regulated secretion of neutrophil chemokines is independent of epithelial-mesenchymal transitions in breast tumor cells.
SenGupta S, Cohen E, Serrenho J, Ott K, Coulombe PA, Parent CA
bioRxiv : the preprint server for biology 2024 Oct 12;
bioRxiv : the preprint server for biology 2024 Oct 12;
Irilin D suppresses RANKL-induced osteoclastogenesis and prevents inflammation-induced bone loss by disrupting the NF-κB and MAPK signaling pathways.
Gal M, Tuan HM, Park JH, Park KH, Kim O, Min BS, Lee JH
European journal of pharmacology 2024 Nov 5;982:176956
European journal of pharmacology 2024 Nov 5;982:176956
Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.
Wang S, Li W, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
bioRxiv : the preprint server for biology 2024 May 3;
bioRxiv : the preprint server for biology 2024 May 3;
Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.
Zhou X, Zhang K, Wang C, Teng Y, Yu P, Cai W, Gao W, Li M, Ding Y, Sun P, Chen F, Wang Y, Ma J, Maeshige N, Ma X, Li Q, Liang X, Zhang Y, Su D
Cancer letters 2024 May 28;590:216868
Cancer letters 2024 May 28;590:216868
Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways.
Wang T, Zhang M, Gong X, Chen W, Peng Y, Liao C, Xu H, Li Q, Shen G, Ren H, Zhu Y, Zhang B, Mao J, Wei L, Chen Y, Yang X
iScience 2024 May 17;27(5):109741
iScience 2024 May 17;27(5):109741
Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury.
Qian Z, Li R, Zhao T, Xie K, Li P, Li G, Shen N, Gong J, Hong X, Yang L, Li H
Cellular & molecular biology letters 2024 May 16;29(1):75
Cellular & molecular biology letters 2024 May 16;29(1):75
Stress Granule Dysfunction via Chromophore-Associated Light Inactivation.
Koizumi T, Fujimoto A, Kawaguchi H, Kurosaki T, Kitamura A
ACS omega 2024 May 14;9(19):21298-21306
ACS omega 2024 May 14;9(19):21298-21306
Foretinib Is Effective in Acute Myeloid Leukemia by Inhibiting FLT3 and Overcoming Secondary Mutations That Drive Resistance to Quizartinib and Gilteritinib.
Wang P, Zhang Y, Xiang R, Yang J, Xu Y, Deng T, Zhou W, Wang C, Xiao X, Wang S
Cancer research 2024 Mar 15;84(6):905-918
Cancer research 2024 Mar 15;84(6):905-918
Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity.
Kitamura A, Fujimoto A, Kawashima R, Lyu Y, Sasaki K, Hamada Y, Moriya K, Kurata A, Takahashi K, Brielmann R, Bott LC, Morimoto RI, Kinjo M
Communications biology 2024 Jun 20;7(1):743
Communications biology 2024 Jun 20;7(1):743
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Bharti R, Dey G, Khan D, Myers A, Huffman OG, Saygin C, Braley C, Richards E, Sangwan N, Willard B, Lathia JD, Fox PL, Lin F, Jha BK, Brown JM, Yu JS, Dwidar M, Joehlin-Price A, Vargas R, Michener CM, Longworth MS, Reizes O
Molecular cancer 2024 Jun 10;23(1):121
Molecular cancer 2024 Jun 10;23(1):121
Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia.
Hu C, Zhang Y, Yang J, Xu Y, Deng T, Li Y, Xu S, Wang S, Wang P
Cell communication and signaling : CCS 2024 Jul 8;22(1):355
Cell communication and signaling : CCS 2024 Jul 8;22(1):355
Light and classical music therapies attenuate chronic unpredictable mild stress-induced depression via BDNF signaling pathway in mice.
Cheng HY, Xie HX, Tang QL, Yi LT, Zhu JX
Heliyon 2024 Jul 15;10(13):e34196
Heliyon 2024 Jul 15;10(13):e34196
IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1.
Chen Y, Huang L, Gan RH, Yuan S, Lan T, Zheng D, Lu YG
Cell death discovery 2024 Feb 6;10(1):65
Cell death discovery 2024 Feb 6;10(1):65
The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis.
Liu S, Bi Y, Han T, Li YE, Wang Q, Wu NN, Xu C, Ge J, Hu R, Zhang Y
Cell discovery 2024 Feb 27;10(1):24
Cell discovery 2024 Feb 27;10(1):24
CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity.
Liu C, Shen M, Liu Y, Manhas A, Zhao SR, Zhang M, Belbachir N, Ren L, Zhang JZ, Caudal A, Nishiga M, Thomas D, Zhang A, Yang H, Zhou Y, Ameen M, Sayed N, Rhee JW, Qi LS, Wu JC
Cell stem cell 2024 Dec 5;31(12):1760-1776.e9
Cell stem cell 2024 Dec 5;31(12):1760-1776.e9
Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition.
Xie X, Zhang B, Li D, Gao J, Li J, Liu C, Dan Y, Xu P, Yan L, Huang X, Zhang R, Yao Y, Huang W, Nie J, Wang X, Jiao B, Ren R, Liu P
Cancer cell international 2024 Dec 5;24(1):396
Cancer cell international 2024 Dec 5;24(1):396
Design of antiviral AGO2-dependent short hairpin RNAs.
Bie Y, Zhang J, Chen J, Zhang Y, Huang M, Zhang L, Zhou X, Qiu Y
Virologica Sinica 2024 Aug;39(4):645-654
Virologica Sinica 2024 Aug;39(4):645-654
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
Tuomivaara ST, Teo CF, Jan YN, Wiita AP, Jan LY
Communications biology 2024 Aug 29;7(1):1060
Communications biology 2024 Aug 29;7(1):1060
Distinct Amino Acid-Based PROTACs Target Oncogenic Kinases for Degradation in Non-Small Cell Lung Cancer (NSCLC).
Zhang J, Chen X, Chen C, Li F, Song X, Liu C, Liao K, Su MY, Tan CSH, Fang L, Rao H
Journal of medicinal chemistry 2024 Aug 22;67(16):13666-13680
Journal of medicinal chemistry 2024 Aug 22;67(16):13666-13680
TGF-β1 activates neutrophil signaling and gene expression but not migration.
Hein LE, SenGupta S, Gunasekaran G, Johnson CN, Parent CA
PloS one 2023;18(9):e0290886
PloS one 2023;18(9):e0290886
Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling.
Lv X, Ding P, Li L, Li L, Zhou D, Wang X, Chen J, Zhang W, Wang Q, Liao T, Wen W, Zhou D, Ji QH, He X, Lei QY, Hu W
Molecular metabolism 2023 Sep;75:101766
Molecular metabolism 2023 Sep;75:101766
Identification of VPS34-PI(3)P-FEN1-mediated DNA repair pathway as a potential drug target to overcome chemoresistance.
Zhang X, Dan S, Pan X, Li J, Wei Q, Huang L, Kang B, Chen C
Biochemical and biophysical research communications 2023 Sep 24;674:27-35
Biochemical and biophysical research communications 2023 Sep 24;674:27-35
TCF12 Activates TGFB2 Expression to Promote the Malignant Progression of Melanoma.
Tian Y, Zhou J, Chai X, Ping Z, Zhao Y, Xu X, Luo C, Sheng J
Cancers 2023 Sep 11;15(18)
Cancers 2023 Sep 11;15(18)
KIAA1429/VIRMA promotes breast cancer progression by m(6) A-dependent cytosolic HAS2 stabilization.
Li N, Zhu Z, Deng Y, Tang R, Hui H, Kang Y, Rana TM
EMBO reports 2023 Oct 9;24(10):e55506
EMBO reports 2023 Oct 9;24(10):e55506
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria.
Zhou Q, Yang Y, Xu Z, Deng K, Zhang Z, Hao J, Li N, Wang Y, Wang Z, Chen H, Yang Y, Xiao F, Zhang X, Gao S, Li YP
EMBO reports 2023 Nov 6;24(11):e56614
EMBO reports 2023 Nov 6;24(11):e56614
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Heng J, Li Z, Liu L, Zheng Z, Zheng Y, Xu X, Liao L, Xu H, Huang H, Li E, Xu L
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
Alphavirus infection triggers antiviral RNAi immunity in mammals.
Kong J, Bie Y, Ji W, Xu J, Lyu B, Xiong X, Qiu Y, Zhou X
Cell reports 2023 May 30;42(5):112441
Cell reports 2023 May 30;42(5):112441
TGF-β1 activates neutrophil signaling and gene expression but not migration.
Hein LE, SenGupta S, Gunasekaran G, Johnson C, Parent CA
bioRxiv : the preprint server for biology 2023 May 27;
bioRxiv : the preprint server for biology 2023 May 27;
The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function.
Critchley WR, Smith GA, Zachary IC, Harrison MA, Ponnambalam S
Journal of cell science 2023 May 15;136(10)
Journal of cell science 2023 May 15;136(10)
The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genes.
Song L, Wang D, Abbas G, Li M, Cui M, Wang J, Lin Z, Zhang XE
The Journal of biological chemistry 2023 Mar;299(3):102990
The Journal of biological chemistry 2023 Mar;299(3):102990
BmCBP Catalyzes the Acetylation of BmApoLp-II Protein and Regulates Its Stability in Silkworm, Bombyx mori.
Chen Y, Lv J, Zu G, Yang F, Geng J, You Z, Jiang C, Sheng Q, Nie Z
Insects 2023 Mar 23;14(4)
Insects 2023 Mar 23;14(4)
Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling.
Wang H, Jia X, Zhang M, Cheng C, Liang X, Wang X, Xie F, Wang J, Yu Y, He Y, Dong Q, Wang Y, Xu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154786
Chemotherapeutic drugs-induced pyroptosis mediated by gasdermin E promotes the progression and chemoresistance of pancreatic cancer.
Li S, Yue M, Xu H, Zhang X, Mao T, Quan M, Ma J, Wang Y, Ge W, Wang Y, Xue S, Shentu D, Cui J, Wang L
Cancer letters 2023 Jun 28;564:216206
Cancer letters 2023 Jun 28;564:216206
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O
Journal of ovarian research 2023 Jun 27;16(1):122
Journal of ovarian research 2023 Jun 27;16(1):122
An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo.
Lee PH, Anaya M, Ladinsky MS, Reitsma JM, Zinn K
eLife 2023 Jun 16;12
eLife 2023 Jun 16;12
Brain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers.
Jung HJ, Yeo S, Jang J, Pleasure S, Choe Y
Brain pathology (Zurich, Switzerland) 2023 Jul;33(4):e13148
Brain pathology (Zurich, Switzerland) 2023 Jul;33(4):e13148
ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality.
Sindram E, Caballero-Oteyza A, Kogata N, Chor Mei Huang S, Alizadeh Z, Gámez-Díaz L, Fazlollhi MR, Peng X, Grimbacher B, Way M, Proietti M
Disease models & mechanisms 2023 Jul 1;16(7)
Disease models & mechanisms 2023 Jul 1;16(7)
Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia.
Zhang Y, Wang P, Wang Y, Shen Y
Biomarker research 2023 Jan 24;11(1):8
Biomarker research 2023 Jan 24;11(1):8
Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling.
Yoon J, Sun J, Lee M, Hwang YS, Daar IO
Nature communications 2023 Jan 20;14(1):337
Nature communications 2023 Jan 20;14(1):337
Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling.
Andreani V, Ramamoorthy S, Fässler R, Grosschedl R
The Journal of experimental medicine 2023 Jan 2;220(1)
The Journal of experimental medicine 2023 Jan 2;220(1)
The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation.
Wei X, Shen Z, Zhu M, Fang M, Wang S, Zhang T, Zhang B, Yang X, Lv Z, Duan Y, Jiang M, Ma C, Li Q, Chen Y
International immunopharmacology 2023 Dec;125(Pt B):111198
International immunopharmacology 2023 Dec;125(Pt B):111198
The MAD2B-APC/C-MDM2 axis mediates acute kidney injury by modulating p53.
Hao Z, Yuan Q, Tang H, Lei C, Chen Y, Su H, Zhang C
The FEBS journal 2023 Aug;290(15):3858-3876
The FEBS journal 2023 Aug;290(15):3858-3876
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
Yan W, Zhong Y, Hu X, Xu T, Zhang Y, Kales S, Qu Y, Talley DC, Baljinnyam B, LeClair CA, Simeonov A, Polster BM, Huang R, Ye Y, Rai G, Henderson MJ, Tao D, Fang S
Nature communications 2023 Aug 9;14(1):4798
Nature communications 2023 Aug 9;14(1):4798
Hedgehog receptors exert immune-surveillance roles in the epidermis across species.
Wang Q, Fu R, Li G, Xiong S, Zhu Y, Zhang H
Cell reports 2023 Aug 29;42(8):112929
Cell reports 2023 Aug 29;42(8):112929
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway.
Wang M, Zhang F, Zhou J, Gong K, Chen S, Zhu X, Zhang M, Duan Y, Liao C, Han J, Yin Z
Nutrients 2023 Apr 30;15(9)
Nutrients 2023 Apr 30;15(9)
FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.
Yang YS, Liu MH, Yan ZW, Chen GQ, Huang Y
Stem cells (Dayton, Ohio) 2023 Apr 25;41(4):354-367
Stem cells (Dayton, Ohio) 2023 Apr 25;41(4):354-367
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
Wen B, Deng DX, Liao LD, Zhang ZD, Zheng YQ, Dong K, Xu LY, Li EM
Biomedicines 2023 Apr 16;11(4)
Biomedicines 2023 Apr 16;11(4)
Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
Thevkar-Nagesh P, Habault J, Voisin M, Ruff SE, Ha S, Ruoff R, Chen X, Rawal S, Zahr T, Szabo G, Rogatsky I, Fisher EA, Garabedian MJ
PloS one 2022;17(9):e0272986
PloS one 2022;17(9):e0272986
Branched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming.
Cai Z, Li W, Brenner M, Bahiraii S, Heiss EH, Weckwerth W
Frontiers in immunology 2022;13:966158
Frontiers in immunology 2022;13:966158
PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex.
Wang X, Wang R, Jiang K, Zhu M, Guo L, Wu C
Theranostics 2022;12(6):2613-2630
Theranostics 2022;12(6):2613-2630
DUSP4 Inactivation Leads to Reduced Extracellular Signal‒Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells.
Kamada H, Yasuhira S, Shibazaki M, Amano H, Maesawa C
The Journal of investigative dermatology 2022 Sep;142(9):2499-2507.e6
The Journal of investigative dermatology 2022 Sep;142(9):2499-2507.e6
Retinal neurodegeneration in a mouse model of green-light-induced myopia.
Ji S, Ye L, Zhang L, Xu D, Dai J
Experimental eye research 2022 Oct;223:109208
Experimental eye research 2022 Oct;223:109208
Pharmacological Inhibition of Class III Alcohol Dehydrogenase 5: Turning Remote Ischemic Conditioning Effective in a Diabetic Stroke Model.
Zaidi SK, Hoda MN, Tabrez S, Khan MI
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans.
Song J, Ni Q, Sun J, Xie J, Liu J, Ning G, Wang W, Wang Q
The Journal of clinical endocrinology and metabolism 2022 Nov 25;107(12):3231-3241
The Journal of clinical endocrinology and metabolism 2022 Nov 25;107(12):3231-3241
Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.
Chen X, Luo R, Zhang Y, Ye S, Zeng X, Liu J, Huang D, Liu Y, Liu Q, Luo ML, Song E
Nature communications 2022 Nov 22;13(1):7160
Nature communications 2022 Nov 22;13(1):7160
Interference in melanoma CD248 function reduces vascular mimicry and metastasis.
Kuo CH, Wu YF, Chang BI, Hsu CK, Lai CH, Wu HL
Journal of biomedical science 2022 Nov 18;29(1):98
Journal of biomedical science 2022 Nov 18;29(1):98
Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis.
Ding P, Xu Y, Li L, Lv X, Li L, Chen J, Zhou D, Wang X, Wang Q, Zhang W, Liao T, Ji QH, Lei QY, Hu W
Cell reports 2022 May 31;39(9):110851
Cell reports 2022 May 31;39(9):110851
GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway.
Qiu Z, Wang X, Yang Z, Liao S, Dong W, Sun T, Wu H, Zhang Q, Pan Z, Lam SM, Shui G, Jin J
Cell death & disease 2022 May 30;13(5):508
Cell death & disease 2022 May 30;13(5):508
Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice.
Zheng L, Wang Y, Shao B, Zhou H, Li X, Zhang C, Sun N, Shi J
Neuroscience bulletin 2022 Jul;38(7):753-768
Neuroscience bulletin 2022 Jul;38(7):753-768
Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.
Zhang Q, Wang S, Li W, Yau E, Hui H, Singh PK, Achuthan V, Young Karris MA, Engelman AN, Rana TM
Nucleic acids research 2022 Jul 8;50(12):6687-6701
Nucleic acids research 2022 Jul 8;50(12):6687-6701
Transcription Factor ASCL1 Acts as a Novel Potential Therapeutic Target for the Treatment of the Cushing's Disease.
Chen Z, Jia Q, Zhao Z, Zhang Q, Chen Y, Qiao N, Ye Z, Ji C, Zhang Y, He W, Shi C, Cai Y, Yao B, Han R, Wang Y, Shou X, Shen M, Cao X, Zhou X, Cheng H, Zhu J, Hu Y, Zhang Z, Ye H, Li Y, Li S, Wang Y, Ma Z, Ni T, Zhao Y
The Journal of clinical endocrinology and metabolism 2022 Jul 14;107(8):2296-2306
The Journal of clinical endocrinology and metabolism 2022 Jul 14;107(8):2296-2306
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis.
Yang X, Chen J, Wang J, Ma S, Feng W, Wu Z, Guo Y, Zhou H, Mi W, Chen W, Yin B, Lin Y
Immunity 2022 Jul 12;55(7):1185-1199.e8
Immunity 2022 Jul 12;55(7):1185-1199.e8
Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer.
Li RY, Zheng ZY, Li ZM, Heng JH, Zheng YQ, Deng DX, Xu XE, Liao LD, Lin W, Xu HY, Huang HC, Li EM, Xu LY
Chemico-biological interactions 2022 Jul 1;361:109967
Chemico-biological interactions 2022 Jul 1;361:109967
Bombyx mori cypovirus (BmCPV) induces PINK1-Parkin mediated mitophagy via interaction of VP4 with host Tom40.
Zhu M, Pan J, Zhang M, Tong X, Zhang Y, Zhang Z, Liang Z, Zhang X, Hu X, Xue R, Cao G, Gong C
Developmental and comparative immunology 2022 Jan;126:104244
Developmental and comparative immunology 2022 Jan;126:104244
ZCL-082, a boron-containing compound, induces apoptosis of non-Hodgkin's lymphoma via targeting p90 ribosomal S6 kinase 1/NF-κB signaling pathway.
Ma C, Liu M, Zhang J, Cai H, Wu Y, Zhang Y, Ji Y, Shan H, Zou Z, Yang L, Liu L, Xu H, Lei H, Liu C, Zhou L, Cao Y, Zhou H, Wu Y
Chemico-biological interactions 2022 Jan 5;351:109770
Chemico-biological interactions 2022 Jan 5;351:109770
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X
The Journal of biological chemistry 2022 Feb;298(2):101561
The Journal of biological chemistry 2022 Feb;298(2):101561
Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development.
Sun J, Yoon J, Lee M, Lee HK, Hwang YS, Daar IO
Cell reports 2022 Feb 1;38(5):110312
Cell reports 2022 Feb 1;38(5):110312
From Initiation to Maintenance: HIV-1 Gp120-induced Neuropathic Pain Exhibits Different Molecular Mechanisms in the Mouse Spinal Cord Via Bioinformatics Analysis Based on RNA Sequencing.
Huang J, Lin F, Hu Y, Bloe CB, Wang D, Zhang W
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2022 Dec;17(3-4):553-575
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2022 Dec;17(3-4):553-575
TNFα activation and TGFβ blockage act synergistically for smooth muscle cell calcification in patients with venous thrombosis via TGFβ/ERK pathway.
Wang P, Pan Y, Yang C, Zhang L, Zhao Z, Ye K, Li L, Xia S, Lu X, Shi H, Li W, Yin M
Journal of cellular and molecular medicine 2022 Aug;26(16):4479-4491
Journal of cellular and molecular medicine 2022 Aug;26(16):4479-4491
Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation.
Wang C, Yang R, Yang F, Han Y, Ren Y, Xiong X, Wang X, Bi Y, Li L, Qiu Y, Xu Y, Zhou X
PLoS pathogens 2022 Aug;18(8):e1010787
PLoS pathogens 2022 Aug;18(8):e1010787
XBP1 variant 1 promotes mitosis of cancer cells involving upregulation of the polyglutamylase TTLL6.
Zhong Y, Yan W, Ruan J, Fang M, Yu C, Du S, Rai G, Tao D, Henderson MJ, Fang S
Human molecular genetics 2022 Aug 17;31(15):2639-2654
Human molecular genetics 2022 Aug 17;31(15):2639-2654
ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells.
Chen R, Michaeloudes C, Liang Y, Bhavsar PK, Chung KF, Ip MSM, Mak JCW
The Journal of allergy and clinical immunology 2022 Apr;149(4):1445-1457.e5
The Journal of allergy and clinical immunology 2022 Apr;149(4):1445-1457.e5
A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration.
Du J, Zheng L, Gao P, Yang H, Yang WJ, Guo F, Liang R, Feng M, Wang Z, Zhang Z, Bai L, Bu Y, Xing S, Zheng W, Wang X, Quan L, Hu X, Wu H, Chen Z, Chen L, Wei K, Zhang Z, Zhu X, Zhang X, Tu Q, Zhao SM, Lei X, Xiong JW
Cell stem cell 2022 Apr 7;29(4):545-558.e13
Cell stem cell 2022 Apr 7;29(4):545-558.e13
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes.
Giordano I, Pirone L, Muratore V, Landaluze E, Pérez C, Lang V, Garde-Lapido E, Gonzalez-Lopez M, Barroso-Gomila O, Vertegaal ACO, Aransay AM, Rodriguez JA, Rodriguez MS, Sutherland JD, Barrio R
Frontiers in cell and developmental biology 2021;9:715868
Frontiers in cell and developmental biology 2021;9:715868
Cardioprotective Role of SIRT5 in Response to Acute Ischemia Through a Novel Liver-Cardiac Crosstalk Mechanism.
Zhou B, Xiao M, Hu H, Pei X, Xue Y, Miao G, Wang J, Li W, Du Y, Zhang P, Wei T
Frontiers in cell and developmental biology 2021;9:687559
Frontiers in cell and developmental biology 2021;9:687559
Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.
Ji R, Ma L, Chen X, Sun R, Zhang L, Saiyin H, Wei W
PloS one 2021;16(11):e0258204
PloS one 2021;16(11):e0258204
100 Hz Electroacupuncture Alleviated Chronic Itch and GRPR Expression Through Activation of Kappa Opioid Receptors in Spinal Dorsal Horn.
Li HP, Wang XY, Chen C, Li JJ, Yu C, Lin LX, Yu ZE, Jin ZY, Zhu H, Xiang HC, Hu XF, Cao J, Jing XH, Li M
Frontiers in neuroscience 2021;15:625471
Frontiers in neuroscience 2021;15:625471
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Bianchi-Smiraglia A, Wolff DW, Marston DJ, Deng Z, Han Z, Moparthy S, Wombacher RM, Mussell AL, Shen S, Chen J, Yun DH, O'Brien Cox A, Furdui CM, Hurley E, Feltri ML, Qu J, Hollis T, Kengne JBN, Fongang B, Sousa RJ, Kandel ME, Kandel ES, Hahn KM, Nikiforov MA
Nature communications 2021 Oct 19;12(1):6091
Nature communications 2021 Oct 19;12(1):6091
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.
Heck AL, Mishra S, Prenzel T, Feulner L, Achhammer E, Särchen V, Blagg BSJ, Schneider-Brachert W, Schütze S, Fritsch J
Immunobiology 2021 Mar;226(2):152070
Immunobiology 2021 Mar;226(2):152070
FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression.
Liu MH, Chen J, Yang YS, Wang YQ, Chen GQ, Zhang Y, Huang Y
Haematologica 2021 Mar 1;106(3):903-907
Haematologica 2021 Mar 1;106(3):903-907
miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5.
Yuan C, Su Z, Liao S, Li D, Zhou Z, Wang Y, Quan M, Zeng L, Lv C, Shen C, Gong W, Wu J, Chen X, Hu W, Lv X, Si W, Yu X
Cancer cell international 2021 Jul 21;21(1):390
Cancer cell international 2021 Jul 21;21(1):390
Involvement of SIRT3-GSK3β deacetylation pathway in the effects of maternal diabetes on oocyte meiosis.
Xin Y, Jin Y, Ge J, Huang Z, Han L, Li C, Wang D, Zhu S, Wang Q
Cell proliferation 2021 Jan;54(1):e12940
Cell proliferation 2021 Jan;54(1):e12940
GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
Xia Z, Zhang X, Liu P, Zhang R, Huang Z, Li D, Xiao X, Wu M, Ning N, Zhang Q, Zhang J, Liu M, Jiao B, Ren R
Cell death & disease 2021 Jan 9;12(1):54
Cell death & disease 2021 Jan 9;12(1):54
PINCH-1 promotes Δ(1)-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma.
Cui C, Wang J, Guo L, Wu C
Amino acids 2021 Dec;53(12):1875-1890
Amino acids 2021 Dec;53(12):1875-1890
RAB27A-dependent release of exosomes by liver cancer stem cells induces Nanog expression in their differentiated progenies and confers regorafenib resistance.
Huang H, Hou J, Liu K, Liu Q, Shen L, Liu B, Lu Q, Zhang N, Che L, Li J, Jiang S, Wang B, Wen Q, Hu L, Gao J
Journal of gastroenterology and hepatology 2021 Dec;36(12):3429-3437
Journal of gastroenterology and hepatology 2021 Dec;36(12):3429-3437
LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway.
Chen L, Qian J, You Q, Ma J
Bioengineered 2021 Dec;12(2):10089-10100
Bioengineered 2021 Dec;12(2):10089-10100
Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection.
Liu J, Xu K, Xing M, Zhuo Y, Guo J, Du M, Wang Q, An Y, Li J, Gao P, Wang Y, He F, Guo Y, Li M, Zhang Y, Zhang L, Gao GF, Dai L, Zhou D
Cell discovery 2021 Dec 18;7(1):123
Cell discovery 2021 Dec 18;7(1):123
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Li YS, Yang X, Zhao DS, Cai Y, Huang Z, Wu R, Wang SJ, Liu GJ, Wang J, Bao XZ, Ye XY, Wei B, Cui ZN, Wang H
European journal of medicinal chemistry 2021 Apr 15;216:113336
European journal of medicinal chemistry 2021 Apr 15;216:113336
Mitochondrial dysfunction caused by novel ATAD3A mutations.
Dorison N, Gaignard P, Bayot A, Gelot A, Becker PH, Fourati S, Lebigot E, Charles P, Wai T, Therond P, Slama A
Molecular genetics and metabolism 2020 Sep-Oct;131(1-2):107-113
Molecular genetics and metabolism 2020 Sep-Oct;131(1-2):107-113
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, Su W, Bao R, Ran J, Wu C
Nature communications 2020 Oct 1;11(1):4913
Nature communications 2020 Oct 1;11(1):4913
Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.
Wang S, Li W, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM
The EMBO journal 2020 Nov 2;39(21):e106057
The EMBO journal 2020 Nov 2;39(21):e106057
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.
Wu X, Spence JS, Das T, Yuan X, Chen C, Zhang Y, Li Y, Sun Y, Chandran K, Hang HC, Peng T
Cell chemical biology 2020 May 21;27(5):571-585.e6
Cell chemical biology 2020 May 21;27(5):571-585.e6
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
Monteleone NJ, Lutz CS
Oncotarget 2020 Jun 30;11(26):2464-2483
Oncotarget 2020 Jun 30;11(26):2464-2483
Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X
Diabetes 2020 Jul;69(7):1355-1367
Diabetes 2020 Jul;69(7):1355-1367
Wnt/β-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV(1) gp120-induced neuropathic pain.
Zhou X, Tao L, Zhao M, Wu S, Obeng E, Wang D, Zhang W
Molecular pain 2020 Jan-Dec;16:1744806920922100
Molecular pain 2020 Jan-Dec;16:1744806920922100
PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.
Huang Z, Liu M, Li D, Tan Y, Zhang R, Xia Z, Wang P, Jiao B, Liu P, Ren R
The Journal of biological chemistry 2020 Dec 25;295(52):18343-18354
The Journal of biological chemistry 2020 Dec 25;295(52):18343-18354
Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria.
Yang R, Mele F, Worley L, Langlais D, Rosain J, Benhsaien I, Elarabi H, Croft CA, Doisne JM, Zhang P, Weisshaar M, Jarrossay D, Latorre D, Shen Y, Han J, Ogishi M, Gruber C, Markle J, Al Ali F, Rahman M, Khan T, Seeleuthner Y, Kerner G, Husquin LT, Maclsaac JL, Jeljeli M, Errami A, Ailal F, Kobor MS, Oleaga-Quintas C, Roynard M, Bourgey M, El Baghdadi J, Boisson-Dupuis S, Puel A, Batteux F, Rozenberg F, Marr N, Pan-Hammarström Q, Bogunovic D, Quintana-Murci L, Carroll T, Ma CS, Abel L, Bousfiha A, Di Santo JP, Glimcher LH, Gros P, Tangye SG, Sallusto F, Bustamante J, Casanova JL
Cell 2020 Dec 23;183(7):1826-1847.e31
Cell 2020 Dec 23;183(7):1826-1847.e31
Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
Rong B, Zhang Q, Wan J, Xing S, Dai R, Li Y, Cai J, Xie J, Song Y, Chen J, Zhang L, Yan G, Zhang W, Gao H, Han JJ, Qu Q, Ma H, Tian Y, Lan F
Cell reports 2020 Dec 22;33(12):108544
Cell reports 2020 Dec 22;33(12):108544
HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.
Xu Q, Li Y, Gao X, Kang K, Williams JG, Tong L, Liu J, Ji M, Deterding LJ, Tong X, Locasale JW, Li L, Shats I, Li X
Nature communications 2020 Aug 7;11(1):3978
Nature communications 2020 Aug 7;11(1):3978
KLF9-dependent ROS regulate melanoma progression in stage-specific manner.
Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA
Oncogene 2019 May;38(19):3585-3597
Oncogene 2019 May;38(19):3585-3597
XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis.
Zhu ZC, Liu JW, Yang C, Zhao M, Xiong ZQ
Cell death & disease 2019 May 21;10(6):395
Cell death & disease 2019 May 21;10(6):395
Synergistic effect of arsenic trioxide, vismodegib and temozolomide on glioblastoma.
Bureta C, Saitoh Y, Tokumoto H, Sasaki H, Maeda S, Nagano S, Komiya S, Taniguchi N, Setoguchi T
Oncology reports 2019 Jun;41(6):3404-3412
Oncology reports 2019 Jun;41(6):3404-3412
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14.
Scheiber IF, Alarcon NO, Zhao N
Nutrients 2019 Jun 28;11(7)
Nutrients 2019 Jun 28;11(7)
Bombyx mori cypovirus encoded small peptide inhibits viral multiplication.
Hu X, Chen F, Zhu L, Yu L, Zhu M, Liang Z, Zhang X, Xue R, Cao G, Gong C
Developmental and comparative immunology 2019 Jul;96:51-57
Developmental and comparative immunology 2019 Jul;96:51-57
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA
Molecular cell 2019 Jul 25;75(2):382-393.e5
Molecular cell 2019 Jul 25;75(2):382-393.e5
The histone deacetylase inhibitor LBH589 inhibits undifferentiated pleomorphic sarcoma growth via downregulation of FOS-like antigen 1.
Saitoh Y, Bureta C, Sasaki H, Nagano S, Maeda S, Furukawa T, Taniguchi N, Setoguchi T
Molecular carcinogenesis 2019 Feb;58(2):234-246
Molecular carcinogenesis 2019 Feb;58(2):234-246
Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells.
Zhu ZC, Liu JW, Yang C, Li MJ, Wu RJ, Xiong ZQ
Cell death & disease 2019 Feb 11;10(2):118
Cell death & disease 2019 Feb 11;10(2):118
Neurotensin receptor 1 is a new therapeutic target for human undifferentiated pleomorphic sarcoma growth.
Tokumoto H, Setoguchi T, Saitoh Y, Sasaki H, Nagano S, Maeda S, Tanimoto A, Taniguchi N
Molecular carcinogenesis 2019 Dec;58(12):2230-2240
Molecular carcinogenesis 2019 Dec;58(12):2230-2240
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS
Nature immunology 2019 Dec;20(12):1644-1655
Nature immunology 2019 Dec;20(12):1644-1655
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
Monteleone NJ, Moore AE, Iacona JR, Lutz CS, Dixon DA
Scientific reports 2019 Apr 1;9(1):5405
Scientific reports 2019 Apr 1;9(1):5405
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Ye C, Zhang C, Huang H, Yang B, Xiao G, Kong D, Tian Q, Song Q, Song Y, Tan H, Wang Y, Zhou T, Zi X, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing.
Wei R, Yuan F, Wu Y, Liu Y, You K, Yang Z, Chen Y, Getachew A, Wang N, Xu Y, Zhuang Y, Yang F, Li YX
Stem cell research 2018 Oct;32:139-144
Stem cell research 2018 Oct;32:139-144
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, Chen J, Su F, Liu Q, Song E
Cell 2018 Oct 4;175(2):442-457.e23
Cell 2018 Oct 4;175(2):442-457.e23
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.
Qiu Y, Xu Y, Zhang Y, Zhou H, Deng YQ, Li XF, Miao M, Zhang Q, Zhong B, Hu Y, Zhang FC, Wu L, Qin CF, Zhou X
Immunity 2018 Oct 16;49(4):780-781
Immunity 2018 Oct 16;49(4):780-781
KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect.
Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM
Annals of neurology 2018 Nov;84(5):766-780
Annals of neurology 2018 Nov;84(5):766-780
[6]-Gingerol enhances the radiosensitivity of gastric cancer via G2/M phase arrest and apoptosis induction.
Luo Y, Chen X, Luo L, Zhang Q, Gao C, Zhuang X, Yuan S, Qiao T
Oncology reports 2018 May;39(5):2252-2260
Oncology reports 2018 May;39(5):2252-2260
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
Zhu ZC, Liu JW, Li K, Zheng J, Xiong ZQ
Oncogene 2018 May;37(22):2936-2952
Oncogene 2018 May;37(22):2936-2952
PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
Papadopoulos N, Lennartsson J, Heldin CH
The Journal of cell biology 2018 May 7;217(5):1701-1717
The Journal of cell biology 2018 May 7;217(5):1701-1717
Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-Cα by ubiquitin-proteasome system.
Fan F, Zhao J, Liu Y, Zhao H, Weng L, Li Q, Chen G, Xu Y
Biochemical and biophysical research communications 2018 Jun 7;500(3):676-681
Biochemical and biophysical research communications 2018 Jun 7;500(3):676-681
miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.
Iacona JR, Monteleone NJ, Lutz CS
Oncotarget 2018 Jun 1;9(42):26751-26769
Oncotarget 2018 Jun 1;9(42):26751-26769
Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice.
Hu LY, Zhou Y, Cui WQ, Hu XM, Du LX, Mi WL, Chu YX, Wu GC, Wang YQ, Mao-Ying QL
Brain, behavior, and immunity 2018 Feb;68:132-145
Brain, behavior, and immunity 2018 Feb;68:132-145
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.
Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurðsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R
American journal of human genetics 2018 Feb 1;102(2):249-265
American journal of human genetics 2018 Feb 1;102(2):249-265
The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.
Purandare N, Somayajulu M, Hüttemann M, Grossman LI, Aras S
The Journal of biological chemistry 2018 Apr 27;293(17):6517-6529
The Journal of biological chemistry 2018 Apr 27;293(17):6517-6529
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.
Qiu Y, Xu Y, Zhang Y, Zhou H, Deng YQ, Li XF, Miao M, Zhang Q, Zhong B, Hu Y, Zhang FC, Wu L, Qin CF, Zhou X
Immunity 2017 Jun 20;46(6):992-1004.e5
Immunity 2017 Jun 20;46(6):992-1004.e5
The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.
Luccarini I, Pantano D, Nardiello P, Cavone L, Lapucci A, Miceli C, Nediani C, Berti A, Stefani M, Casamenti F
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Journal of Alzheimer's disease : JAD 2016 Sep 6;54(2):737-50
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death.
Fritsch J, Fickers R, Klawitter J, Särchen V, Zingler P, Adam D, Janssen O, Krause E, Schütze S
Oncotarget 2016 Nov 15;7(46):75774-75789
Oncotarget 2016 Nov 15;7(46):75774-75789
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D
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Nature chemical biology 2016 Apr;12(4):218-25
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Western blot analysis of alpha-tubulin in various tissues and cell lines using Proteintech antibody HRP-60031 at a dilution of 1:5000.
- Sample type
- tissue
