HRP-66031

antibody from Proteintech Group

Targeting: TUBA1B K-ALPHA-1

Provider product page for HRP-66031

Western blot

Antibody data

Antibody Data
Antigen structure
References [112]
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Validations
Western blot [1]

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Product number: HRP-66031 - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#HRP-66031, RRID:AB_2687491
Product name: alpha Tubulin antibody
Antibody type: Monoclonal
Description: Alpha Tubulin antibody (Cat. #HRP-66031) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Horseradish Peroxidase
Isotype: IgG
Vial size: 100ul

TUBA1B protein structure - HRP-66031 shown in red.

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Haematologica 2021 Mar 1;106(3):903-907

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Cancer cell international 2021 Jul 21;21(1):390

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Cell death & disease 2021 Jan 9;12(1):54

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LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway.

Chen L, Qian J, You Q, Ma J
Bioengineered 2021 Dec;12(2):10089-10100

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Cell discovery 2021 Dec 18;7(1):123

Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.

Li YS, Yang X, Zhao DS, Cai Y, Huang Z, Wu R, Wang SJ, Liu GJ, Wang J, Bao XZ, Ye XY, Wei B, Cui ZN, Wang H
European journal of medicinal chemistry 2021 Apr 15;216:113336

Mitochondrial dysfunction caused by novel ATAD3A mutations.

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PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.

Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, Su W, Bao R, Ran J, Wu C
Nature communications 2020 Oct 1;11(1):4913

Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.

Wang S, Li W, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM
The EMBO journal 2020 Nov 2;39(21):e106057

Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.

Wu X, Spence JS, Das T, Yuan X, Chen C, Zhang Y, Li Y, Sun Y, Chandran K, Hang HC, Peng T
Cell chemical biology 2020 May 21;27(5):571-585.e6

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.

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Oncotarget 2020 Jun 30;11(26):2464-2483

Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.

Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X
Diabetes 2020 Jul;69(7):1355-1367

Wnt/β-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV(1) gp120-induced neuropathic pain.

Zhou X, Tao L, Zhao M, Wu S, Obeng E, Wang D, Zhang W
Molecular pain 2020 Jan-Dec;16:1744806920922100

PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.

Huang Z, Liu M, Li D, Tan Y, Zhang R, Xia Z, Wang P, Jiao B, Liu P, Ren R
The Journal of biological chemistry 2020 Dec 25;295(52):18343-18354

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria.

Yang R, Mele F, Worley L, Langlais D, Rosain J, Benhsaien I, Elarabi H, Croft CA, Doisne JM, Zhang P, Weisshaar M, Jarrossay D, Latorre D, Shen Y, Han J, Ogishi M, Gruber C, Markle J, Al Ali F, Rahman M, Khan T, Seeleuthner Y, Kerner G, Husquin LT, Maclsaac JL, Jeljeli M, Errami A, Ailal F, Kobor MS, Oleaga-Quintas C, Roynard M, Bourgey M, El Baghdadi J, Boisson-Dupuis S, Puel A, Batteux F, Rozenberg F, Marr N, Pan-Hammarström Q, Bogunovic D, Quintana-Murci L, Carroll T, Ma CS, Abel L, Bousfiha A, Di Santo JP, Glimcher LH, Gros P, Tangye SG, Sallusto F, Bustamante J, Casanova JL
Cell 2020 Dec 23;183(7):1826-1847.e31

Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.

Rong B, Zhang Q, Wan J, Xing S, Dai R, Li Y, Cai J, Xie J, Song Y, Chen J, Zhang L, Yan G, Zhang W, Gao H, Han JJ, Qu Q, Ma H, Tian Y, Lan F
Cell reports 2020 Dec 22;33(12):108544

HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.

Xu Q, Li Y, Gao X, Kang K, Williams JG, Tong L, Liu J, Ji M, Deterding LJ, Tong X, Locasale JW, Li L, Shats I, Li X
Nature communications 2020 Aug 7;11(1):3978

KLF9-dependent ROS regulate melanoma progression in stage-specific manner.

Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA
Oncogene 2019 May;38(19):3585-3597

XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis.

Zhu ZC, Liu JW, Yang C, Zhao M, Xiong ZQ
Cell death & disease 2019 May 21;10(6):395

Synergistic effect of arsenic trioxide, vismodegib and temozolomide on glioblastoma.

Bureta C, Saitoh Y, Tokumoto H, Sasaki H, Maeda S, Nagano S, Komiya S, Taniguchi N, Setoguchi T
Oncology reports 2019 Jun;41(6):3404-3412

Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14.

Scheiber IF, Alarcon NO, Zhao N
Nutrients 2019 Jun 28;11(7)

Bombyx mori cypovirus encoded small peptide inhibits viral multiplication.

Hu X, Chen F, Zhu L, Yu L, Zhu M, Liang Z, Zhang X, Xue R, Cao G, Gong C
Developmental and comparative immunology 2019 Jul;96:51-57

An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.

Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA
Molecular cell 2019 Jul 25;75(2):382-393.e5

The histone deacetylase inhibitor LBH589 inhibits undifferentiated pleomorphic sarcoma growth via downregulation of FOS-like antigen 1.

Saitoh Y, Bureta C, Sasaki H, Nagano S, Maeda S, Furukawa T, Taniguchi N, Setoguchi T
Molecular carcinogenesis 2019 Feb;58(2):234-246

Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells.

Zhu ZC, Liu JW, Yang C, Li MJ, Wu RJ, Xiong ZQ
Cell death & disease 2019 Feb 11;10(2):118

Neurotensin receptor 1 is a new therapeutic target for human undifferentiated pleomorphic sarcoma growth.

Tokumoto H, Setoguchi T, Saitoh Y, Sasaki H, Nagano S, Maeda S, Tanimoto A, Taniguchi N
Molecular carcinogenesis 2019 Dec;58(12):2230-2240

Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.

Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS
Nature immunology 2019 Dec;20(12):1644-1655

miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.

Monteleone NJ, Moore AE, Iacona JR, Lutz CS, Dixon DA
Scientific reports 2019 Apr 1;9(1):5405

The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.

Ye C, Zhang C, Huang H, Yang B, Xiao G, Kong D, Tian Q, Song Q, Song Y, Tan H, Wang Y, Zhou T, Zi X, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244

Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing.

Wei R, Yuan F, Wu Y, Liu Y, You K, Yang Z, Chen Y, Getachew A, Wang N, Xu Y, Zhuang Y, Yang F, Li YX
Stem cell research 2018 Oct;32:139-144

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, Chen J, Su F, Liu Q, Song E
Cell 2018 Oct 4;175(2):442-457.e23

Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.

Qiu Y, Xu Y, Zhang Y, Zhou H, Deng YQ, Li XF, Miao M, Zhang Q, Zhong B, Hu Y, Zhang FC, Wu L, Qin CF, Zhou X
Immunity 2018 Oct 16;49(4):780-781

KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect.

Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM
Annals of neurology 2018 Nov;84(5):766-780

[6]-Gingerol enhances the radiosensitivity of gastric cancer via G2/M phase arrest and apoptosis induction.

Luo Y, Chen X, Luo L, Zhang Q, Gao C, Zhuang X, Yuan S, Qiao T
Oncology reports 2018 May;39(5):2252-2260

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.

Zhu ZC, Liu JW, Li K, Zheng J, Xiong ZQ
Oncogene 2018 May;37(22):2936-2952

PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.

Papadopoulos N, Lennartsson J, Heldin CH
The Journal of cell biology 2018 May 7;217(5):1701-1717

Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-Cα by ubiquitin-proteasome system.

Fan F, Zhao J, Liu Y, Zhao H, Weng L, Li Q, Chen G, Xu Y
Biochemical and biophysical research communications 2018 Jun 7;500(3):676-681

miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.

Iacona JR, Monteleone NJ, Lutz CS
Oncotarget 2018 Jun 1;9(42):26751-26769

Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice.

Hu LY, Zhou Y, Cui WQ, Hu XM, Du LX, Mi WL, Chu YX, Wu GC, Wang YQ, Mao-Ying QL
Brain, behavior, and immunity 2018 Feb;68:132-145

Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.

Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurðsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R
American journal of human genetics 2018 Feb 1;102(2):249-265

Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.

Qiu Y, Xu Y, Zhang Y, Zhou H, Deng YQ, Li XF, Miao M, Zhang Q, Zhong B, Hu Y, Zhang FC, Wu L, Qin CF, Zhou X
Immunity 2017 Jun 20;46(6):992-1004.e5

The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study.

Luccarini I, Pantano D, Nardiello P, Cavone L, Lapucci A, Miceli C, Nediani C, Berti A, Stefani M, Casamenti F
Journal of Alzheimer's disease : JAD 2016 Sep 6;54(2):737-50

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Western blot analysis of alpha-tubulin in various tissues and cell lines using Proteintech antibody HRP-60031 at a dilution of 1:5000.
Sample type: tissue