Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-12008-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-MEIS1 Antibody
- Antibody type
- Polyclonal
- Description
- Myeloid ecotropoic viral insertion site 1 (MEIS1) is a transcription factor belonging to TALE (three amino acids loop extension) family. The gene for MEIS1 is mapped to human chromosome 2p15. The amino terminus contains binding domains for its interaction partners, the transcription factors HOXA9 and PBX1, followed by a homeobox DNA binding domain and carboxy-terminal transcriptional activation domains. It is expressed in hematopoietic stem and progenitor cells and increases during human megakaryocytic differentiation. MEIS1 plays a role in the normal development of the hematopoietic lineage and is over expressed in a subset of acute myeloid leukemias. Increased MEIS1 expression has also been observed in neuroblastomas and the expression level of the MEIS1 transcript is a prognostic indicator in breast cancer.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant MEIS1
protein (amino acids 163-352) was u
sed as the immunogen for this antib
ody.- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
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- Experimental details
- Expression analysis of MEIS1. Anti-MEIS1 antibody (11-12008) was used at 1 µg/ml on h Heart lysate.