Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8775 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PHIP polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- PH-interacting protein; PHIP; IRS-1 PH domain-binding protein; WD repeat-containing protein 11; PHIP; WDR11
- Description
- PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary ÉÇ cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing ÉÇ cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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