14599-1-AP

antibody from Proteintech Group

Targeting: HNRNPU C1orf199, FLJ30202, FLJ37978, HNRNPU-AS1, HNRPU, NCRNA00201, SAF-A

Provider product page for 14599-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [32]
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Validations
Western blot [1]

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Product number: 14599-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14599-1-AP, RRID:AB_2248577
Product name: HNRNPU antibody
Antibody type: Polyclonal
Description: HNRNPU antibody (Cat. #14599-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HNRNPU protein structure - 14599-1-AP shown in red.

Submitted references GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling.

Chai P, Kheiri S, Kuo A, Shah J, Kageler L, Ge R, Perr J, Porat J, Lebedenko CG, Dias JML, Yankova E, Rai SK, Watkins CP, Hristov P, Tzelepis K, Hla T, Raman R, Calo E, Esko JD, Flynn RA
Nature 2026 Mar;651(8106):808-818

AURKB-driven dissolution of CIZ1-RNA assemblies from the inactive X chromosome in mitosis.

Byrom L, Turvey GL, Dowle AA, Thomas M, Shirodkar N, Green BJ, Brown M, Ball C, Chapman KE, Guglielmi E, Dickson W, Noon E, Sofi S, Ainscough JF, Antson AA, Coverley D
Nucleic acids research 2026 Jan 22;54(3)

Long non-coding RNA STMN1P2 promotes breast cancer doxorubicin resistance by inhibiting pyroptosis through the hnRNPU-EZH2-TARF6-MALT1-caspase-1 pathway.

Jin YP, Xu BJ, Zhang XF, Wang X, Wang L, Li LY, Chen SY, Zhu P, Zhi XL, Lv L, Wang CF, Wang ZL, Sun YB, Zhou P
Acta pharmacologica Sinica 2026 Feb;47(2):419-433

Mannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis.

Jin H, He H, Li J, Liu X, Cai Q, Shi J, Hao Z, He J
International journal of biological sciences 2025;21(4):1566-1584

The molecular axis hnRNPU/circKCNK2/EDC4/IL-11 aggravates osteolytic bone metastasis of RCC.

Wang Y, Zhao D, Lu J, Hou N, Wu Q, Zhou S, Xu J, Xue W, Cui W, Zheng J, Wang F, Zhai W
Oncogene 2025 Sep;44(36):3310-3332

Gene Therapy with Enterovirus 3 C Protease: A Promising Strategy for Various Solid Tumors.

Yang X, Li W, Yang S, Wang Z, Yin J, Zhang W, Tao H, Li S, Guo X, Dai Q, Zhu W, Li Y, Yan X, Luo C, Li J, Ren S, Wang P, Shao Y, Luo Y, Li Z, Yang J, Chang Z, Cao R, Li S, Zhong W
Nature communications 2025 May 8;16(1):4298

SFTSV NSs degrades SAFA via autophagy to suppress SAFA-dependent antiviral response.

Yu TM, Li ZM, Zhang WK, Li B, Liu Q, Zhou CM, Yu XJ
PLoS pathogens 2025 Jun;21(6):e1013201

RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis.

Zhang W, Peng Y, Zhou M, Qian L, Che Y, Chen J, Zhang W, He C, Qi M, Shu X, Tian M, Tian X, Tian Y, Deng S, Wang Y, Huo X, Yu Z, Ma X
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3059-3072

hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression.

Jin G, Song Y, Fang S, Yan M, Yang Z, Shao Y, Zhao K, Liu M, Wang Z, Guo Z, Dong Z
Journal of experimental & clinical cancer research : CR 2025 Jan 7;44(1):8

The nuclear matrix stabilizes primed-specific genes in human pluripotent stem cells.

Ma G, Fu X, Zhou L, Babarinde IA, Shi L, Yang W, Chen J, Xiao Z, Qiao Y, Ma L, Ou Y, Li Y, Chang C, Deng B, Zhang R, Sun L, Tong G, Li D, Li Y, Hutchins AP
Nature cell biology 2025 Feb;27(2):232-245

Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling.

Yu J, Li Y, Li Y, Liu X, Huo Q, Wu N, Zhang Y, Zeng T, Zhang Y, Li HY, Lian J, Zhou J, Moses EJ, Geng J, Lin J, Li W, Zhu X
Nature communications 2025 Feb 21;16(1):1865

ZDHHC9 and spermine metabolism: a palmitoylation-driven pathway to prostate carcinogenesis.

Chen C, Zhang Y, Wang G, Liu Y, Ye B, Zhou S, Wang K, Zheng H, Dong X, Luo C, Zhou J, Zeng K, Fang C, Shen L
Journal of translational medicine 2025 Dec 19;24(1):103

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry.

Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA
Cell 2025 Apr 3;188(7):1878-1895.e25

Virus-modified paraspeckle-like condensates are hubs for viral RNA processing and their formation drives genomic instability.

Harper KL, Harrington EM, Hayward C, Anene CA, Wongwiwat W, White RE, Whitehouse A
Nature communications 2024 Nov 26;15(1):10240

CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.

Wen X, Fang G, Li H, Jiang Z, Du X, Liao Z, Liu R, Huang G, Meng F, Liao W, Zhang Z
International journal of biological macromolecules 2024 Jan;256(Pt 2):128453

LncRNA evf-2 Exacerbates Podocyte Injury in Diabetic Nephropathy by Inducing Cell Cycle Re-entry and Inflammation Through Distinct Mechanisms Triggered by hnRNPU.

Zhang C, Zhao H, Yan Y, Li Y, Lei M, Liu Y, Yang L, Zhao H, Zhou S, Pan S, Liu Z, Guo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406532

Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression.

Wu X, Cao C, Li Z, Xie Y, Zhang S, Sun W, Guo J
Digestive diseases and sciences 2024 Apr;69(4):1200-1213

p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway.

Zhu X, Huang B, Zhao F, Lian J, He L, Zhang Y, Ji L, Zhang J, Yan X, Zeng T, Ma C, Liang Y, Zhang C, Lin J
Nucleic acids research 2023 Mar 21;51(5):2195-2214

Human lncRNA SUGCT-AS1 Regulates the Proinflammatory Response of Macrophage.

Lim YH, Yoon G, Ryu Y, Jeong D, Song J, Kim YS, Ahn Y, Kook H, Kim YK
International journal of molecular sciences 2023 Aug 28;24(17)

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.

Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ
eLife 2023 Apr 24;12

SRSF3 facilitates replication of influenza A virus via binding and promoting the transport of viral mRNA.

Zhao L, Li Y, Zhao Y, Liu Q, Lu Y, Ping J
Veterinary microbiology 2022 Mar;266:109343

Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.

Zhang S, Huang W, Ren L, Ju X, Gong M, Rao J, Sun L, Li P, Ding Q, Wang J, Zhang QC
Cell research 2022 Jan;32(1):9-23

Circulating Exosomal miR-493-3p Affects Melanocyte Survival and Function by Regulating Epidermal Dopamine Concentration in Segmental Vitiligo.

Li D, Zhou T, She Q, Nie X, Liu Z, Pan R, Wei Y, Deng Y
The Journal of investigative dermatology 2022 Dec;142(12):3262-3273.e11

Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.

Cai D, Han JJ
Nature aging 2021 May;1(5):438-453

Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.

Li WJ, He YH, Yang JJ, Hu GS, Lin YA, Ran T, Peng BL, Xie BL, Huang MF, Gao X, Huang HH, Zhu HH, Ye F, Liu W
Nature communications 2021 Mar 29;12(1):1946

hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.

Akinyemi AR, Li D, Zhang J, Liu Q
Neuroscience letters 2021 Apr 23;751:135824

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.

Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132

DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing.

Xing S, Li Z, Ma W, He X, Shen S, Wei H, Li ST, Shu Y, Sun L, Zhong X, Huangfu Y, Su L, Feng J, Zhang X, Gao P, Jia WD, Zhang H
Cancer research 2019 Oct 1;79(19):4923-4936

O-GlcNAcylation of Thr(12)/Ser(56) in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.

Liu L, Li L, Ma C, Shi Y, Liu C, Xiao Z, Zhang Y, Tian F, Gao Y, Zhang J, Ying W, Wang PG, Zhang L
The Journal of biological chemistry 2019 Nov 8;294(45):16620-16633

Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins.

Majewski L, Nowak J, Sobczak M, Karatsai O, Havrylov S, Lenartowski R, Suszek M, Lenartowska M, Redowicz MJ
Nucleus (Austin, Tex.) 2018 Jan 1;9(1):125-141

Identification of novel PANDAR protein interaction partners involved in splicing regulation.

Pospiech N, Cibis H, Dietrich L, Müller F, Bange T, Hennig S
Scientific reports 2018 Feb 12;8(1):2798

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.

Suzuki H, Shibagaki Y, Hattori S, Matsuoka M
Human molecular genetics 2015 Mar 15;24(6):1513-27

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The HNRNPU antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HNRNPU. This antibody recognizes human, mouse, rat antigen. The HNRNPU antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14599-1-AP.pdf

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