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- Product number
- ABIN2839144 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 702-731), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 702-731, C-Term
- Antibody clone number
- RB4107-4108
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity.
Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7.
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
Schwamborn JC, Khazaei MR, Püschel AW
The Journal of biological chemistry 2007 Nov 30;282(48):35259-68
The Journal of biological chemistry 2007 Nov 30;282(48):35259-68
Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7.
Tajima Y, Goto K, Yoshida M, Shinomiya K, Sekimoto T, Yoneda Y, Miyazono K, Imamura T
The Journal of biological chemistry 2003 Mar 21;278(12):10716-21
The Journal of biological chemistry 2003 Mar 21;278(12):10716-21
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.
Suzuki C, Murakami G, Fukuchi M, Shimanuki T, Shikauchi Y, Imamura T, Miyazono K
The Journal of biological chemistry 2002 Oct 18;277(42):39919-25
The Journal of biological chemistry 2002 Oct 18;277(42):39919-25
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.
Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K
The Journal of biological chemistry 2001 Apr 20;276(16):12477-80
The Journal of biological chemistry 2001 Apr 20;276(16):12477-80
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH
Nature 1999 Aug 12;400(6745):687-93
Nature 1999 Aug 12;400(6745):687-93
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