Antibody data

Product number
Ab128409 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant SMURF2 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human SMURF2 Antibody, Recombinant (R06-5K4), could be used for WB and so on.Application:WB: 1/500-1/2000Protein functionE3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 215-280
Antibody clone number
R06-5K4
Vial size
100μl,10μl,1ml,50μl
Concentration
0,5 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
SMURF2 protein structure - Ab128409 shown in red.