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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [107]
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- Product number
- 66974-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Hexokinase 2 antibody
- Antibody type
- Monoclonal
- Description
- Hexokinase 2 antibody (Cat. #66974-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2A11C3
- Vial size
- 20ul, 150ul
Submitted references Gomphus floccosus (Schw.) Sing. extract attenuates alcoholic liver disease by suppressing macrophage glycolysis and M1 polarization.
ENO1 inhibition synergizes with chidamide to induce ferroptosis in PTCL-NOS through metabolic remodeling.
HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis.
RNA-seq and ChIP-seq reveal microplastics induce endothelial-mesenchymal transition via HK2-mediated histone lactylation in pulmonary hypertension.
The GAP43/RAC1 axis drives glycolytic reprogramming and progression in lung adenocarcinoma.
HMGB1-mediated enhancement of glycolysis activates hepatic stellate cells by inhibiting ferroptosis in alcoholic hepatic fibrosis.
Mechanism of HAND2 Regulating Glycolytic Metabolism and Metastasis Through TLR4/NOX2/DUOX2 Signaling Axis in Cervical Cancer.
RPL35A drives aerobic glycolysis and tumorigenesis by facilitating MYC-mediated SKP2 transcription.
Super enhancer-driven LINC01013 mediates hypoxia-induced mitochondrial dysfunction by HSPA9 to determine pulmonary arterial smooth muscle cell fate.
STING Degradation by PRRSV Activates HK(2)-Mediated Glycolysis to Facilitate Viral Replication.
NEAT1 drives SARS-CoV-2 N protein-induced inflammation, metabolic reprogramming, and mitochondria-ER stress crosstalk.
Baicalin alleviates repeated superovulation induced ovarian dysfunction and oocyte impairment by suppressing excessive glycolysis.
OSBPL3 promotes LUAD metastasis and glycolysis through transcriptional upregulation of PLAU via NFE2L2.
KSR2 functions as a metabolic checkpoint for anti-PD-1 resistance by reprogramming glucose metabolism.
Solute carrier family 6 member 3 promotes the development of clear cell renal cell carcinoma by enhancing glycolysis and inhibiting ferroptosis.
CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation.
IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis.
Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD.
Hexokinase-2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming.
Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation.
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.
Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis.
FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism.
Rutin alleviates preoperative anxiety stress-induced persistent postoperative pain by inhibiting microglia-mediated abnormal synaptic engulfment in the spinal cord dorsal horn.
Mycobacterium bovis induces macrophage mitochondrial release of hexokinase 2 to enhance intracellular survival.
Mogroside V restores glycolytic function via LDHA promoter demethylation independent of alternative splicing in PCOS granulosa cells.
Dexmedetomidine alleviates sepsis-induced acute lung injury by inhibiting M1 macrophage polarization via inhibition of PKM2-mediated Warburg effect.
EBV-miR-BART5-3p promotes the proliferation of Burkitt lymphoma cells via glycolytic pathway.
Apigenin combined with cisplatin suppressed the progression of colorectal cancer by targeting the KRT23/Wnt/β-catenin signaling pathway.
Zhenqi Fuzheng Granule targets the SCFAs-GPR109A axis to enhance PD-1 antibody efficacy via immunometabolic remodeling in colorectal cancer.
HOXA9 drives lymphatic metastasis by activating the c-MYC-glycolysis-lactate axis in gastric cancer.
PFKFB4 promotes endometrial cancer by regulating glycolysis through SRC‑3 phosphorylation.
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy-lysosomal pathway in endometrial cancer.
Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia.
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.
LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1.
Near-infrared light-driven metabolic reprogramming of synoviocytes for the treatment of rheumatoid arthritis.
SESN2 mediates resistance training-induced improvements in exercise performance and energy metabolism in C57BL/6J mice.
Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling.
A peptide encoded by LINC00944 suppresses the growth of melanoma cells by diminishing EP400-MYC interaction.
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis.
GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway.
Spatial metabolomics revealed mTOR-mediated gastric epithelial repair by licorice (G. inflata) flavonoids.
Hepatoblastoma-Derived Exosomal FASN Affected the Differentiation of Hepatic Stellate Cells Into Cancer-Associated Fibroblasts by Regulating the Stability of HK2 and Mediating Histone Lactylation.
RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux.
Identification and targeting oxidative phosphorylation/glycolysis to overcome anti-CSF-1R therapy resistance in glioblastoma.
Aquaporin-1 Facilitates Macrophage M1 Polarization by Enhancing Glycolysis Through the Activation of HIF1α in Lipopolysaccharide-Induced Acute Kidney Injury.
RASGEF1C affects aerobic glycolysis and facilitates lung cancer progression through the PLK1 signaling pathway.
TXNIP participates in the pathogenesis of PCOS by regulating glycolysis in granulosa cells.
A Constant Filgotinib Delivery Adhesive Platform Based on Polyethylene Glycol (PEG) Hydrogel for Accelerating Wound Healing via Restoring Macrophage Mitochondrial Homeostasis.
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer's disease.
Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin.
Integrin β3 enhances glycolysis and increases lactate production in endometriosis.
Validation of quercetin in the treatment of colon cancer with diabetes via network pharmacology, molecular dynamics simulations, and in vitro experiments.
HSP90β shapes the fate of Th17 cells with the help of glycolysis-controlled methylation modification.
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage.
Glycometabolism and lipid metabolism related genes predict the prognosis of endometrial carcinoma and their effects on tumor cells.
CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis.
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Dachengqi decoction alleviates acute lung injury by suppressing HIF-1α-mediated glycolysis.
TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis.
AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.
Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma.
Design, synthesis and biological evaluation of plant-derived miliusol derivatives achieve TNBC profound regression in vivo.
Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth.
TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.
Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function.
Elevated expression of glycolytic genes as a prominent feature of early-onset preeclampsia: insights from integrative transcriptomic analysis.
MYL9 promotes squamous cervical cancer migration and invasion by enhancing aerobic glycolysis.
HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma.
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
HIF-1α Mediates Arsenic-Induced Metabolic Reprogramming in Lung Bronchial Epithelial Cells.
TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties.
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism.
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.
USP7 promotes non-small-cell lung cancer cell glycolysis and survival by stabilizing and activating c-Abl.
The regulation of cell homeostasis and antiviral innate immunity by autophagy during classical swine fever virus infection.
Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.
NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK.
Glucose-Induced Activation of mTORC1 is Associated with Hexokinase2 Binding to Sestrins in HEK293T Cells.
Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity.
The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
Bleomycin restricts the glycolysis of lymphatic endothelial cells by inhibiting dimeric PKM2 formation: A novel mechanism for lymphatic malformation treatment.
Novel long non-coding RNA CYB561-5 promotes aerobic glycolysis and tumorigenesis by interacting with basigin in non-small cell lung cancer.
Engineering of thick human functional myocardium via static stretching and electrical stimulation.
Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.
Phosphorylation and acetylation of glycolytic enzymes cooperatively regulate their activity and lamb meat quality.
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway.
Bmal1 Regulates Macrophage Polarize Through Glycolytic Pathway in Alcoholic Liver Disease.
Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.
MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis.
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection.
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Ruan T, Li X, Li M, Wang S, Shen L, Liu C, Peng Y, Tao Y
Frontiers in immunology 2026;17:1772592
Frontiers in immunology 2026;17:1772592
ENO1 inhibition synergizes with chidamide to induce ferroptosis in PTCL-NOS through metabolic remodeling.
Zhu F, Tian M, Lu K, Wang C, Liu J, Li X, Gu X, Lv B, Huang Z, Zeng L, Li Z, Lu H, Xu K
Blood science (Baltimore, Md.) 2026 Mar;8(1):e00272
Blood science (Baltimore, Md.) 2026 Mar;8(1):e00272
HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis.
Zhang Y, Li L, Li G, Zhu J, Qi Z, Zhang C
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168140
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168140
RNA-seq and ChIP-seq reveal microplastics induce endothelial-mesenchymal transition via HK2-mediated histone lactylation in pulmonary hypertension.
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The GAP43/RAC1 axis drives glycolytic reprogramming and progression in lung adenocarcinoma.
Li K, Shen C, Li Y, Zhang Q, Guo J
Respiratory research 2026 Mar 18;27(1)
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HMGB1-mediated enhancement of glycolysis activates hepatic stellate cells by inhibiting ferroptosis in alcoholic hepatic fibrosis.
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Stem cell research & therapy 2026 Mar 16;17(1)
Mechanism of HAND2 Regulating Glycolytic Metabolism and Metastasis Through TLR4/NOX2/DUOX2 Signaling Axis in Cervical Cancer.
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Molecular carcinogenesis 2026 Jun;65(6):699-714
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RPL35A drives aerobic glycolysis and tumorigenesis by facilitating MYC-mediated SKP2 transcription.
Yan L, Chen Y, Cao D, Hou M, Xue T, Zhang X
The Journal of biological chemistry 2026 Jan;302(1):110944
The Journal of biological chemistry 2026 Jan;302(1):110944
Super enhancer-driven LINC01013 mediates hypoxia-induced mitochondrial dysfunction by HSPA9 to determine pulmonary arterial smooth muscle cell fate.
Ma C, Wang Z, Zhu X, Pang X, Zhang L, Ou L, Chen Y, Liu Y, Mei J, Guan X, Meng Z, Tang Y, Zhang Z, Li B, Wen S, Shen A, Wang X
Cellular and molecular life sciences : CMLS 2026 Jan 6;83(1):57
Cellular and molecular life sciences : CMLS 2026 Jan 6;83(1):57
STING Degradation by PRRSV Activates HK(2)-Mediated Glycolysis to Facilitate Viral Replication.
Luo L, Zhou L, Gao X, Li Y, Zhou H, Li Y, Zhang Z
Viruses 2026 Feb 27;18(3)
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NEAT1 drives SARS-CoV-2 N protein-induced inflammation, metabolic reprogramming, and mitochondria-ER stress crosstalk.
Qing C, Chen H, Huang S, Zhang J, Zhou C, Zhang S, Luo K, Wang C, Hu Z, Yang Y, Zhou J, Zeng Z
Scientific reports 2026 Feb 25;16(1)
Scientific reports 2026 Feb 25;16(1)
Baicalin alleviates repeated superovulation induced ovarian dysfunction and oocyte impairment by suppressing excessive glycolysis.
Li LF, Shen H, Qi ZM, Luo T, Liu SM, Ou LL, Xu CL, Liu Y
Theriogenology 2026 Aug;260:117934
Theriogenology 2026 Aug;260:117934
OSBPL3 promotes LUAD metastasis and glycolysis through transcriptional upregulation of PLAU via NFE2L2.
Zhang Q, Zhang J, Li J, Chen S, Liu Y, Li K, Guo M
Translational oncology 2026 Apr;66:102693
Translational oncology 2026 Apr;66:102693
KSR2 functions as a metabolic checkpoint for anti-PD-1 resistance by reprogramming glucose metabolism.
Ge Y, Zhou Q, Zhang Q, Hu Y, Wang R
Cancer immunology, immunotherapy : CII 2026 Apr 21;75(5)
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Solute carrier family 6 member 3 promotes the development of clear cell renal cell carcinoma by enhancing glycolysis and inhibiting ferroptosis.
Zhao H, Ji Y, Liang C
CytoJournal 2025;22:65
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CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation.
Li J, Wang N, Bi J, Guo M, Xu B, Huang G
Frontiers in genetics 2025;16:1687066
Frontiers in genetics 2025;16:1687066
IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis.
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Frontiers in oncology 2025;15:1512177
Frontiers in oncology 2025;15:1512177
Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD.
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Hexokinase-2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming.
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Wang M, Wang Y, Chen L, Yu S, Li X, Huang G, Jin M
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European journal of pharmacology 2025 Sep 5;1002:177839
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.
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Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis.
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BMC complementary medicine and therapies 2025 Oct 9;25(1):365
BMC complementary medicine and therapies 2025 Oct 9;25(1):365
FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism.
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International immunopharmacology 2025 Oct 30;164:115309
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Mycobacterium bovis induces macrophage mitochondrial release of hexokinase 2 to enhance intracellular survival.
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Cell reports 2025 Oct 28;44(10):116421
Cell reports 2025 Oct 28;44(10):116421
Mogroside V restores glycolytic function via LDHA promoter demethylation independent of alternative splicing in PCOS granulosa cells.
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The Journal of steroid biochemistry and molecular biology 2025 Nov;254:106839
The Journal of steroid biochemistry and molecular biology 2025 Nov;254:106839
Dexmedetomidine alleviates sepsis-induced acute lung injury by inhibiting M1 macrophage polarization via inhibition of PKM2-mediated Warburg effect.
He Y, Xie W, Zhou H, Wang Y, Chen L, Xu Z, Feng Y, Liu G, Liu J, Li X, Lv Y, Bai Y, Hu D, Wu Q
Biochemical pharmacology 2025 Nov;241:117130
Biochemical pharmacology 2025 Nov;241:117130
EBV-miR-BART5-3p promotes the proliferation of Burkitt lymphoma cells via glycolytic pathway.
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Apigenin combined with cisplatin suppressed the progression of colorectal cancer by targeting the KRT23/Wnt/β-catenin signaling pathway.
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HOXA9 drives lymphatic metastasis by activating the c-MYC-glycolysis-lactate axis in gastric cancer.
Lu T, Shen G, Huang T, Mao X, He J, Hu Y
Journal of translational medicine 2025 Nov 17;23(1):1294
Journal of translational medicine 2025 Nov 17;23(1):1294
PFKFB4 promotes endometrial cancer by regulating glycolysis through SRC‑3 phosphorylation.
Wu Y, Zhao J, Zhao S, Li J, Luo J, Wang Y
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Oncology reports 2025 May;53(5)
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
Peng C, Lei P, Qi H, Zhu Q, Huang C, Fu J, Zhao C
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy-lysosomal pathway in endometrial cancer.
Mao X, Huang L, Liu X, Lin X, Wu Q, Wang X, Ren Y, Ma J, Zhang M, Lin Y, Ralser DJ, Mustea A, Chen G, Sun P
Cell death & disease 2025 Mar 17;16(1):182
Cell death & disease 2025 Mar 17;16(1):182
Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia.
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Communications biology 2025 Jun 2;8(1):845
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.
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World journal of gastroenterology 2025 Jul 28;31(28):107361
World journal of gastroenterology 2025 Jul 28;31(28):107361
LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1.
Ou L, Meng Z, Mei J, Yuan H, Zhu X, Wang X, Shen A, Wang Z, Zhang L, Wang S, Chen Y, Pang X, Liu Y, Xu Y, Ma C
Acta biochimica et biophysica Sinica 2025 Jul 22;57(12):1953-68
Acta biochimica et biophysica Sinica 2025 Jul 22;57(12):1953-68
Near-infrared light-driven metabolic reprogramming of synoviocytes for the treatment of rheumatoid arthritis.
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Nature communications 2025 Jul 17;16(1):6590
Nature communications 2025 Jul 17;16(1):6590
SESN2 mediates resistance training-induced improvements in exercise performance and energy metabolism in C57BL/6J mice.
Huang Y, Sun S, Yang X, Li X, Zhou Y, Liu S, Niu Y, Fu L
Experimental cell research 2025 Jul 1;450(1):114617
Experimental cell research 2025 Jul 1;450(1):114617
Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling.
Liu Z, Zheng X, Li N, Wang Z
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Molecular medicine reports 2025 Jan;31(1)
A peptide encoded by LINC00944 suppresses the growth of melanoma cells by diminishing EP400-MYC interaction.
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Biochemical pharmacology 2025 Jan;231:116652
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
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Autophagy 2025 Jan;21(1):191-209
CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis.
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Journal of experimental & clinical cancer research : CR 2025 Jan 27;44(1):26
GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway.
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Cancer & metabolism 2025 Jan 27;13(1):3
Spatial metabolomics revealed mTOR-mediated gastric epithelial repair by licorice (G. inflata) flavonoids.
Wu Y, Guo Y, Huang D, Huang T, Li Y, Wang Z, Liu L, Shen C, Jiang C, Zheng Z, Liang T, Zhai D, Zhu H, Liu Q
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Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 3):117408
Hepatoblastoma-Derived Exosomal FASN Affected the Differentiation of Hepatic Stellate Cells Into Cancer-Associated Fibroblasts by Regulating the Stability of HK2 and Mediating Histone Lactylation.
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Comprehensive Physiology 2025 Dec;15(6):e70080
RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux.
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Identification and targeting oxidative phosphorylation/glycolysis to overcome anti-CSF-1R therapy resistance in glioblastoma.
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Cell death & disease 2025 Dec 10;17(1):84
Cell death & disease 2025 Dec 10;17(1):84
Aquaporin-1 Facilitates Macrophage M1 Polarization by Enhancing Glycolysis Through the Activation of HIF1α in Lipopolysaccharide-Induced Acute Kidney Injury.
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Inflammation 2025 Aug;48(4):1775-1790
RASGEF1C affects aerobic glycolysis and facilitates lung cancer progression through the PLK1 signaling pathway.
Wu H, Zheng K, Han F
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Expert review of anticancer therapy 2025 Aug;25(8):961-971
TXNIP participates in the pathogenesis of PCOS by regulating glycolysis in granulosa cells.
Zhu R, Yang L, Li Y
Biochemical and biophysical research communications 2025 Aug 15;775:152149
Biochemical and biophysical research communications 2025 Aug 15;775:152149
A Constant Filgotinib Delivery Adhesive Platform Based on Polyethylene Glycol (PEG) Hydrogel for Accelerating Wound Healing via Restoring Macrophage Mitochondrial Homeostasis.
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Small (Weinheim an der Bergstrasse, Germany) 2025 Apr;21(14):e2408791
Small (Weinheim an der Bergstrasse, Germany) 2025 Apr;21(14):e2408791
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
Hu X, Xie J, Su J
Journal of nanobiotechnology 2025 Apr 5;23(1):276
Journal of nanobiotechnology 2025 Apr 5;23(1):276
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer's disease.
Chen H, Li N, Liu N, Zhu H, Ma C, Ye Y, Shi X, Luo G, Dong X, Tan T, Wei X, Yin H
Alzheimer's research & therapy 2025 Apr 5;17(1):72
Alzheimer's research & therapy 2025 Apr 5;17(1):72
Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin.
Liao X, Xie Q, Liang M, Liao Q, Huang B, Zhang S, Zhang F, Wang L, Yuan L, Liu X, Wen S, Luo C, Wang D, Chen Y, Luo H, Shu Y
Signal transduction and targeted therapy 2025 Apr 23;10(1):131
Signal transduction and targeted therapy 2025 Apr 23;10(1):131
Integrin β3 enhances glycolysis and increases lactate production in endometriosis.
Gao X, Shao W, Wang J, Gao H, Zhang X, Xia C, Li M, Liu S
Journal of reproductive immunology 2024 Sep;165:104312
Journal of reproductive immunology 2024 Sep;165:104312
Validation of quercetin in the treatment of colon cancer with diabetes via network pharmacology, molecular dynamics simulations, and in vitro experiments.
Zhou W, Cao W, Wang M, Yang K, Zhang X, Liu Y, Zhang P, Zhang Z, Cao G, Chen B, Xiong M
Molecular diversity 2024 Oct;28(5):2947-2965
Molecular diversity 2024 Oct;28(5):2947-2965
HSP90β shapes the fate of Th17 cells with the help of glycolysis-controlled methylation modification.
Yang L, Zhu JC, Li SJ, Zeng X, Xue XR, Dai Y, Wei ZF
British journal of pharmacology 2024 Oct;181(20):3886-3907
British journal of pharmacology 2024 Oct;181(20):3886-3907
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z
Journal of advanced research 2024 Nov;65:89-104
Journal of advanced research 2024 Nov;65:89-104
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Chen YZ, Wang WK, Yang YF, Cheng SY, Li LF, Shen H, Qi ZM, Liu Y
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage.
Lu S, Li R, Deng Y, Bai J, Ji B, Chu Y, Xu Y, Qu H, Guo X, Li P, Meng M
Respiratory research 2024 May 9;25(1):201
Respiratory research 2024 May 9;25(1):201
Glycometabolism and lipid metabolism related genes predict the prognosis of endometrial carcinoma and their effects on tumor cells.
Lin X, Zheng J, Cai X, Liu L, Jiang S, Liu Q, Sun Y
BMC cancer 2024 May 8;24(1):571
BMC cancer 2024 May 8;24(1):571
CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis.
Yu SK, Yu T, Wang YM, Sun A, Liu J, Lu KH
Journal of translational medicine 2024 May 15;22(1):460
Journal of translational medicine 2024 May 15;22(1):460
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Wang R, Min Q, Guo Y, Zhou Y, Zhang X, Wang D, Gao Y, Wei L
iScience 2024 Mar 15;27(3):109246
iScience 2024 Mar 15;27(3):109246
Dachengqi decoction alleviates acute lung injury by suppressing HIF-1α-mediated glycolysis.
Shang L, Zhang M, Li J, Zhou F, Wang S, Chen L, Yang S
Journal of ethnopharmacology 2024 Mar 1;321:117410
Journal of ethnopharmacology 2024 Mar 1;321:117410
TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.
Chen Y, Han Z, Zhang L, Gao C, Wei J, Yang X, Han Y, Li Y, Zhang C, Wei Y, Dong J, Xun W, Sun W, Zhang T, Zhang H, Chen J, Yuan P
Journal of translational medicine 2024 Jan 4;22(1):21
Journal of translational medicine 2024 Jan 4;22(1):21
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
Yu H, Li X, Li Y, Wang T, Wang M, Mao P
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396
LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis.
Wu J, Chen Q, Wang Y, Wang R, Chen Q, Wang Y, Qi X, Gao Y, Chen K
Journal of gastrointestinal oncology 2024 Feb 29;15(1):271-285
Journal of gastrointestinal oncology 2024 Feb 29;15(1):271-285
AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.
Sun Y, Zhang S, Zhang X, Li G, Sun F, Wang M, Ren C, Jiang A, Yang T
Endocrinology 2024 Feb 20;165(4)
Endocrinology 2024 Feb 20;165(4)
Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma.
Lyu Z, Mahenderan A, Radhakrishnan AKGK, Chin YS, Yin C
3 Biotech 2024 Dec;14(12):307
3 Biotech 2024 Dec;14(12):307
Design, synthesis and biological evaluation of plant-derived miliusol derivatives achieve TNBC profound regression in vivo.
Zhao X, Cheng X, Liu Z, Chen W, Hao W, Ma S, Zhang J, Huang W, Yao D
European journal of medicinal chemistry 2024 Dec 5;279:116882
European journal of medicinal chemistry 2024 Dec 5;279:116882
Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth.
Gu J, Xiao X, Zou C, Mao Y, Jin C, Fu D, Li R, Li H
Journal of translational medicine 2024 Dec 20;22(1):1135
Journal of translational medicine 2024 Dec 20;22(1):1135
TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.
Meng Z, Wang Y, Wang X, Han X
Archives of oral biology 2024 Aug;164:105977
Archives of oral biology 2024 Aug;164:105977
Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function.
Liu Z, Han X, You Y, Xin G, Li L, Gao J, Meng H, Cao C, Liu J, Zhang Y, Li L, Fu J
Journal of ethnopharmacology 2024 Apr 6;323:117690
Journal of ethnopharmacology 2024 Apr 6;323:117690
Elevated expression of glycolytic genes as a prominent feature of early-onset preeclampsia: insights from integrative transcriptomic analysis.
He J, Yang H, Liu Z, Chen M, Ye Y, Tao Y, Li S, Fang J, Xu J, Wu X, Qi H
Frontiers in molecular biosciences 2023;10:1248771
Frontiers in molecular biosciences 2023;10:1248771
MYL9 promotes squamous cervical cancer migration and invasion by enhancing aerobic glycolysis.
Wen B, Luo L, Zeng Z, Luo X
The Journal of international medical research 2023 Nov;51(11):3000605231208582
The Journal of international medical research 2023 Nov;51(11):3000605231208582
HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma.
Kou F, Wu L, Zheng Y, Yi Y, Ji Z, Huang Z, Guo S, Yang L
Oncogene 2023 Nov;42(46):3407-3421
Oncogene 2023 Nov;42(46):3407-3421
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
Zhou P, Chang WY, Gong DA, Xia J, Chen W, Huang LY, Liu R, Liu Y, Chen C, Wang K, Tang N, Huang AL
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
HIF-1α Mediates Arsenic-Induced Metabolic Reprogramming in Lung Bronchial Epithelial Cells.
Wang W, Zhang A
Biological trace element research 2023 May;201(5):2284-2293
Biological trace element research 2023 May;201(5):2284-2293
TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties.
Cao M, Liu Z, You D, Pan Y, Zhang Q
Stem cell research & therapy 2023 May 4;14(1):119
Stem cell research & therapy 2023 May 4;14(1):119
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
Gou Y, Wang H, Wang T, Wang H, Wang B, Jiao N, Yu Y, Cao Y, Wang H, Zhang Z
Immunology 2023 Mar;168(3):389-402
Immunology 2023 Mar;168(3):389-402
Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism.
Xu HL, Zhou X, Chen S, Xu S, Li Z, Nakanishi H, Gao XD
Communications biology 2023 Mar 11;6(1):259
Communications biology 2023 Mar 11;6(1):259
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.
Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y
Journal of translational medicine 2023 Jan 13;21(1):24
Journal of translational medicine 2023 Jan 13;21(1):24
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.
Gu R, Dai F, Xiang C, Chen J, Yang D, Tan W, Wang Z, Liu H, Cheng Y
The Journal of steroid biochemistry and molecular biology 2023 Dec;235:106410
The Journal of steroid biochemistry and molecular biology 2023 Dec;235:106410
USP7 promotes non-small-cell lung cancer cell glycolysis and survival by stabilizing and activating c-Abl.
He Y, Jiang S, Zhong Y, Wang X, Cui Y, Liang J, Sun Y, Zhu Z, Huang Z, Mao X
Clinical and translational medicine 2023 Dec;13(12):e1509
Clinical and translational medicine 2023 Dec;13(12):e1509
The regulation of cell homeostasis and antiviral innate immunity by autophagy during classical swine fever virus infection.
Li X, Song Y, Wang X, Fu C, Zhao F, Zou L, Wu K, Chen W, Li Z, Fan J, Li Y, Li B, Zeng S, Liu X, Zhao M, Yi L, Chen J, Fan S
Emerging microbes & infections 2023 Dec;12(1):2164217
Emerging microbes & infections 2023 Dec;12(1):2164217
Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.
Liu Y, Tang Y, Jiang H, Zhang X, Chen X, Guo J, Jin C, Wu M
Biomolecules 2023 Dec 28;14(1)
Biomolecules 2023 Dec 28;14(1)
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.
Zheng Y, Zhan Y, Zhang Y, Zhang Y, Liu Y, Xie Y, Sun Y, Qian J, Ding Y, Ding Y, Fang Y
Cell death & disease 2023 Aug 1;14(8):488
Cell death & disease 2023 Aug 1;14(8):488
NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK.
Liu H, Lei W, Li Z, Wang X, Zhou L
Journal of cellular and molecular medicine 2023 Apr;27(8):1069-1082
Journal of cellular and molecular medicine 2023 Apr;27(8):1069-1082
Glucose-Induced Activation of mTORC1 is Associated with Hexokinase2 Binding to Sestrins in HEK293T Cells.
Roberson PA, Kincheloe GN, Welles JE, Xu D, Sam-Clarke M, MacLean PS, Lang CH, Jefferson LS, Kimball SR
The Journal of nutrition 2023 Apr;153(4):988-998
The Journal of nutrition 2023 Apr;153(4):988-998
Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity.
Wang R, Li J, Zhang C, Guan X, Qin B, Jin R, Qin L, Xu S, Zhang X, Liu R, Ye Q, Cheng L
Frontiers in oncology 2022;12:821620
Frontiers in oncology 2022;12:821620
The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y
Cell death & disease 2022 Sep 5;13(9):767
Cell death & disease 2022 Sep 5;13(9):767
Bleomycin restricts the glycolysis of lymphatic endothelial cells by inhibiting dimeric PKM2 formation: A novel mechanism for lymphatic malformation treatment.
Chai M, Wang R, Jiang H, Zhu T, Liu J, Huang C, Zhong W, Cai Y
Biochemical pharmacology 2022 Oct;204:115227
Biochemical pharmacology 2022 Oct;204:115227
Novel long non-coding RNA CYB561-5 promotes aerobic glycolysis and tumorigenesis by interacting with basigin in non-small cell lung cancer.
Li L, Li Z, Qu J, Wei X, Suo F, Xu J, Liu X, Chen C, Zheng S
Journal of cellular and molecular medicine 2022 Mar;26(5):1402-1412
Journal of cellular and molecular medicine 2022 Mar;26(5):1402-1412
Engineering of thick human functional myocardium via static stretching and electrical stimulation.
Pretorius D, Kahn-Krell AM, LaBarge WC, Lou X, Zhang J
iScience 2022 Mar 18;25(3):103824
iScience 2022 Mar 18;25(3):103824
Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.
Qi H, Chen Z, Qin Y, Wang X, Zhang Z, Li Y
Oncology letters 2022 Jun;23(6):184
Oncology letters 2022 Jun;23(6):184
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.
Xu L, Yang TY, Zhou YW, Wu MF, Shen J, Cheng JL, Liu QX, Cao SY, Wang JQ, Zhang L
Acta pharmacologica Sinica 2022 Feb;43(2):316-329
Acta pharmacologica Sinica 2022 Feb;43(2):316-329
Phosphorylation and acetylation of glycolytic enzymes cooperatively regulate their activity and lamb meat quality.
Ren C, Li X, Bai Y, Schroyen M, Zhang D
Food chemistry 2022 Dec 15;397:133739
Food chemistry 2022 Dec 15;397:133739
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
Yang K, Wu K, Feng J, Yutian L, Zhu X, Xu D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581
Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway.
Wen LJ, Hu XL, Li CY, Liu J, Li ZY, Li YZ, Zhou JY
American journal of translational research 2021;13(11):12536-12548
American journal of translational research 2021;13(11):12536-12548
Bmal1 Regulates Macrophage Polarize Through Glycolytic Pathway in Alcoholic Liver Disease.
Zhou Y, Wu M, Xu L, Cheng J, Shen J, Yang T, Zhang L
Frontiers in pharmacology 2021;12:640521
Frontiers in pharmacology 2021;12:640521
Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.
Tao Y, Shao F, Cai M, Liu Z, Peng Y, Huang Q, Meng F
Frontiers in oncology 2021;11:714598
Frontiers in oncology 2021;11:714598
MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis.
Zhang D, He Z, Shen Y, Wang J, Liu T, Jiang J
Frontiers in oncology 2021;11:651535
Frontiers in oncology 2021;11:651535
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
Li M, Chen X, Wang X, Wei X, Wang D, Liu X, Xu L, Batu W, Li Y, Guo B, Zhang L
Biochemical pharmacology 2021 Oct;192:114741
Biochemical pharmacology 2021 Oct;192:114741
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Li Y, Kang J, Fu J, Luo H, Liu Y, Li Y, Sun L
International journal of molecular sciences 2021 Mar 3;22(5)
International journal of molecular sciences 2021 Mar 3;22(5)
Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection.
Li M, Yang J, Ye C, Bian P, Yang X, Zhang H, Luo C, Xue Z, Lei Y, Lian J
Virologica Sinica 2021 Dec;36(6):1554-1565
Virologica Sinica 2021 Dec;36(6):1554-1565
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Deng X, Zhao J, Qu L, Duan Z, Fu R, Zhu C, Fan D
Biochemical pharmacology 2020 Aug;178:114038
Biochemical pharmacology 2020 Aug;178:114038
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