66974-1-Ig

antibody from Proteintech Group

Targeting: HK2

Provider product page for 66974-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [42]
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Product number: 66974-1-Ig - Provider product page
Provider: Proteintech Group
Product name: Hexokinase 2 antibody
Antibody type: Monoclonal
Description: Hexokinase 2 antibody (Cat. #66974-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2A11C3
Vial size: 20ul, 150ul

HK2 protein structure - 66974-1-Ig shown in red.

Submitted references CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis.

Yu SK, Yu T, Wang YM, Sun A, Liu J, Lu KH
Journal of translational medicine 2024 May 15;22(1):460

GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.

Wang R, Min Q, Guo Y, Zhou Y, Zhang X, Wang D, Gao Y, Wei L
iScience 2024 Mar 15;27(3):109246

Dachengqi decoction alleviates acute lung injury by suppressing HIF-1α-mediated glycolysis.

Shang L, Zhang M, Li J, Zhou F, Wang S, Chen L, Yang S
Journal of ethnopharmacology 2024 Mar 1;321:117410

TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.

Chen Y, Han Z, Zhang L, Gao C, Wei J, Yang X, Han Y, Li Y, Zhang C, Wei Y, Dong J, Xun W, Sun W, Zhang T, Zhang H, Chen J, Yuan P
Journal of translational medicine 2024 Jan 4;22(1):21

MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.

Yu H, Li X, Li Y, Wang T, Wang M, Mao P
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396

LINC01977 promotes colorectal cancer growth and metastasis by enhancing aerobic glycolysis via the ERK/c-Myc axis.

Wu J, Chen Q, Wang Y, Wang R, Chen Q, Wang Y, Qi X, Gao Y, Chen K
Journal of gastrointestinal oncology 2024 Feb 29;15(1):271-285

AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.

Sun Y, Zhang S, Zhang X, Li G, Sun F, Wang M, Ren C, Jiang A, Yang T
Endocrinology 2024 Feb 20;165(4)

TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.

Meng Z, Wang Y, Wang X, Han X
Archives of oral biology 2024 Aug;164:105977

Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function.

Liu Z, Han X, You Y, Xin G, Li L, Gao J, Meng H, Cao C, Liu J, Zhang Y, Li L, Fu J
Journal of ethnopharmacology 2024 Apr 6;323:117690

Elevated expression of glycolytic genes as a prominent feature of early-onset preeclampsia: insights from integrative transcriptomic analysis.

He J, Yang H, Liu Z, Chen M, Ye Y, Tao Y, Li S, Fang J, Xu J, Wu X, Qi H
Frontiers in molecular biosciences 2023;10:1248771

Validation of quercetin in the treatment of colon cancer with diabetes via network pharmacology, molecular dynamics simulations, and in vitro experiments.

Zhou W, Cao W, Wang M, Yang K, Zhang X, Liu Y, Zhang P, Zhang Z, Cao G, Chen B, Xiong M
Molecular diversity 2023 Sep 25;

MYL9 promotes squamous cervical cancer migration and invasion by enhancing aerobic glycolysis.

Wen B, Luo L, Zeng Z, Luo X
The Journal of international medical research 2023 Nov;51(11):3000605231208582

HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma.

Kou F, Wu L, Zheng Y, Yi Y, Ji Z, Huang Z, Guo S, Yang L
Oncogene 2023 Nov;42(46):3407-3421

High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.

Zhou P, Chang WY, Gong DA, Xia J, Chen W, Huang LY, Liu R, Liu Y, Chen C, Wang K, Tang N, Huang AL
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6

HIF-1α Mediates Arsenic-Induced Metabolic Reprogramming in Lung Bronchial Epithelial Cells.

Wang W, Zhang A
Biological trace element research 2023 May;201(5):2284-2293

TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties.

Cao M, Liu Z, You D, Pan Y, Zhang Q
Stem cell research & therapy 2023 May 4;14(1):119

Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.

Gou Y, Wang H, Wang T, Wang H, Wang B, Jiao N, Yu Y, Cao Y, Wang H, Zhang Z
Immunology 2023 Mar;168(3):389-402

Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism.

Xu HL, Zhou X, Chen S, Xu S, Li Z, Nakanishi H, Gao XD
Communications biology 2023 Mar 11;6(1):259

Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.

Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y
Journal of translational medicine 2023 Jan 13;21(1):24

BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.

Gu R, Dai F, Xiang C, Chen J, Yang D, Tan W, Wang Z, Liu H, Cheng Y
The Journal of steroid biochemistry and molecular biology 2023 Dec;235:106410

USP7 promotes non-small-cell lung cancer cell glycolysis and survival by stabilizing and activating c-Abl.

He Y, Jiang S, Zhong Y, Wang X, Cui Y, Liang J, Sun Y, Zhu Z, Huang Z, Mao X
Clinical and translational medicine 2023 Dec;13(12):e1509

The regulation of cell homeostasis and antiviral innate immunity by autophagy during classical swine fever virus infection.

Li X, Song Y, Wang X, Fu C, Zhao F, Zou L, Wu K, Chen W, Li Z, Fan J, Li Y, Li B, Zeng S, Liu X, Zhao M, Yi L, Chen J, Fan S
Emerging microbes & infections 2023 Dec;12(1):2164217

Liu Y, Tang Y, Jiang H, Zhang X, Chen X, Guo J, Jin C, Wu M
Biomolecules 2023 Dec 28;14(1)

Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.

Zheng Y, Zhan Y, Zhang Y, Zhang Y, Liu Y, Xie Y, Sun Y, Qian J, Ding Y, Ding Y, Fang Y
Cell death & disease 2023 Aug 1;14(8):488

NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK.

Liu H, Lei W, Li Z, Wang X, Zhou L
Journal of cellular and molecular medicine 2023 Apr;27(8):1069-1082

Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity.

Wang R, Li J, Zhang C, Guan X, Qin B, Jin R, Qin L, Xu S, Zhang X, Liu R, Ye Q, Cheng L
Frontiers in oncology 2022;12:821620

The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.

Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y
Cell death & disease 2022 Sep 5;13(9):767

Bleomycin restricts the glycolysis of lymphatic endothelial cells by inhibiting dimeric PKM2 formation: A novel mechanism for lymphatic malformation treatment.

Chai M, Wang R, Jiang H, Zhu T, Liu J, Huang C, Zhong W, Cai Y
Biochemical pharmacology 2022 Oct;204:115227

Novel long non-coding RNA CYB561-5 promotes aerobic glycolysis and tumorigenesis by interacting with basigin in non-small cell lung cancer.

Li L, Li Z, Qu J, Wei X, Suo F, Xu J, Liu X, Chen C, Zheng S
Journal of cellular and molecular medicine 2022 Mar;26(5):1402-1412

Engineering of thick human functional myocardium via static stretching and electrical stimulation.

Pretorius D, Kahn-Krell AM, LaBarge WC, Lou X, Zhang J
iScience 2022 Mar 18;25(3):103824

Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.

Qi H, Chen Z, Qin Y, Wang X, Zhang Z, Li Y
Oncology letters 2022 Jun;23(6):184

Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.

Xu L, Yang TY, Zhou YW, Wu MF, Shen J, Cheng JL, Liu QX, Cao SY, Wang JQ, Zhang L
Acta pharmacologica Sinica 2022 Feb;43(2):316-329

Phosphorylation and acetylation of glycolytic enzymes cooperatively regulate their activity and lamb meat quality.

Ren C, Li X, Bai Y, Schroyen M, Zhang D
Food chemistry 2022 Dec 15;397:133739

Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.

Yang K, Wu K, Feng J, Yutian L, Zhu X, Xu D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581

Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway.

Wen LJ, Hu XL, Li CY, Liu J, Li ZY, Li YZ, Zhou JY
American journal of translational research 2021;13(11):12536-12548

Bmal1 Regulates Macrophage Polarize Through Glycolytic Pathway in Alcoholic Liver Disease.

Zhou Y, Wu M, Xu L, Cheng J, Shen J, Yang T, Zhang L
Frontiers in pharmacology 2021;12:640521

Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.

Tao Y, Shao F, Cai M, Liu Z, Peng Y, Huang Q, Meng F
Frontiers in oncology 2021;11:714598

MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis.

Zhang D, He Z, Shen Y, Wang J, Liu T, Jiang J
Frontiers in oncology 2021;11:651535

RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.

Li M, Chen X, Wang X, Wei X, Wang D, Liu X, Xu L, Batu W, Li Y, Guo B, Zhang L
Biochemical pharmacology 2021 Oct;192:114741

PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.

Li Y, Kang J, Fu J, Luo H, Liu Y, Li Y, Sun L
International journal of molecular sciences 2021 Mar 3;22(5)

Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection.

Li M, Yang J, Ye C, Bian P, Yang X, Zhang H, Luo C, Xue Z, Lei Y, Lian J
Virologica Sinica 2021 Dec;36(6):1554-1565

Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.

Deng X, Zhao J, Qu L, Duan Z, Fu R, Zhu C, Fan D
Biochemical pharmacology 2020 Aug;178:114038

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