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- Product number
- 22029-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22029-1-AP, RRID:AB_11182717
- Product name
- Hexokinase 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Hexokinase 2 antibody (Cat. #22029-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination.
Targeting Myeloid FoxO1 Ameliorates Sepsis-induced Intestinal Injury by Modulating Tim4(+) Macrophage Glycolysis.
Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway.
Programmable bacteria-driven biohybrid triggers spatiotemporal-controlled STING activation to potentiate cuproptosis-based cancer therapy.
Zuoguiyin modulates M2 macrophage polarization to inhibit glycolysis in esophageal squamous cell carcinoma.
Ginsenoside Re regulates PFKFB3-mediated glycolysis to inhibit endothelial cell migration to ameliorate atherosclerosis.
Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells.
Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.
Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular Dementia Based on Multi-Omics Approach.
Echinacoside modulates PARP14-GLUD1 axis to mediate energy metabolism reprogramming and mitochondrial function in diminished ovarian reserve.
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Neuronal ACVR1-mediated H3K18 lactylation drives NLRP3 pyroptosis to sustain neuropathic pain via metabolic-epigenetic coupling.
Curcumin inhibits colorectal cancer progression by regulating MDH2-mediated glycolysis and NAD(+) metabolism.
Propranolol accelerates adipogenesis and inhibits endothelium differentiation of HemSCs via suppressing HK2 mediated glycolysis.
USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1.
pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy.
Notopterol attenuates synovitis via α7nAChR-dependent metabolic reprogramming of macrophage polarisation.
ULK2 suppresses glycolysis to attenuate cisplatin resistance in ovarian cancer organoid via c-Jun phosphorylation.
Maternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase.
Ptbp2 Alleviates Neuroinflammation and Blood-brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke.
N-nitrosodimethylamine increased glucose production by promoting hyperglycemia in hepatocyte via AMPK signaling pathway in vivo and in vitro.
Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress.
(18)F-FDG PET imaging reveals GW4869's suppression of glioblastoma malignant progression and reversal of TMZ chemoresistance via glucose metabolic phenotype remodeling.
Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis.
Porcine epidemic diarrhea virus promotes viral replication via ROS/HIF-1α-mediated glycolysis.
High-Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice.
ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells.
Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar.
Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis.
Unlocking an Efficient SOD-to-CAT Catalytic Relay in a MOF Nanozyme via Dopamine-Driven Interfacial Nanoreconstruction for Osteoarthritis Therapy.
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
Integrative metabolomics and lipidomics reveal Jian-Pi-Yi-Shen formula improves adenine-induced CKD rats by regulating intrarenal glycolipid metabolism.
Ubiquitin C-terminal hydrolase L5 promotes the development of renal cell carcinoma through the glycolysis mediated by the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity.
Layered Double Hydroxide Nanoparticles Loaded with Resveratrol Inhibit Glycolysis and Show Efficacy in the Treatment of Breast Cancer.
Enhancing Quercetin's Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema.
Artemether ameliorates type 1 diabetes mellitus by modulating glycolipid metabolism in skeletal muscle.
Parishin E from ginger-processed Gastrodia elata Bl. alleviates rheumatoid arthritis by regulating histone 3 lactylation at H3K18la and H3K27la sites.
Panoramic view of MDH1: driving cancer progression and shaping the tumor immune microenvironment.
Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progression.
Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells.
SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome.
sPLA2-IB and PLA2R Mediate Aberrant Glucose Metabolism in Podocytes via Hyperactivation of the mTOR/HIF-1α Pathway.
HBV Precore G1896A Mutation Promotes Malignancy of Hepatocellular Carcinoma by Activating Endoplasmic Reticulum Stress to Enhance Aerobic Glycolysis.
ZMYND8 promotes the Warburg effect and tumorigenesis through c-Myc activation in pancreatic cancer.
Complement C1q inhibits the immune escape of mycobacterium tuberculosis associated with macrophage inflammation levels and glycolytic activation.
Self-Assembling Amphiphilic Peptides Target the VDAC1-Hexokinase-II Complex to Induce Apoptosis in Cervical Carcinoma Cells.
Cancer-associated fibroblast derived CXCL14 drives cisplatin chemoresistance by enhancing nucleotide excision repair in bladder cancer.
3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay.
Astragaloside IV alleviates radiation-induced heart disease by regulating energy metabolism.
Microcystin-LR disrupts ovarian granulosa cell glycolysis via GSK3β-Mediated HK2 mitochondrial dissociation: Evidence from integrated In Vivo and In Vitro models.
BCL-2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in AML.
Skullcapflavone II Suppresses Colorectal Cancer by Inhibiting the HIF-1α-Glycolysis Pathway.
Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production.
TRIB3 promotes endometrial cancer progression through interacting with E2F1 and enhancing PKM2-mediated tumor glycolysis.
Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia.
eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring.
IL17A Mediates Glycolysis-Dependent Primary Angiogenesis and Exacerbates Ischemic Stroke Injury.
Astragalin rescues Cadmium-induced cognitive decline by revering glial metabolic reprogramming and neuroinflammation via the mTOR/HIF-1α axis.
Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia.
Effective-compounds of Jinshui Huanxian Formula acts as an SRC inhibitor to inhibit HK2-mediated H3K18 lactation and improve pulmonary fibrosis.
The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis.
Qingyihuaji formula reprograms metabolism to suppress pancreatic cancer growth and progression through LINC00346-OMA1-ATF4 signaling.
Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic ductal adenocarcinoma.
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Pubescenoside D Ameliorates Myocardial Ischemia-Reperfusion Injury via Preventing the Dissociation of HK2 and Promoting Mitophagy by Targeting GSK-3β.
Knockdown of SESN2 Exacerbates Cerebral Ischemia-Reperfusion Injury Through Enhancing Glycolysis via the mTOR/HIF-1α Pathway.
USP27 promotes glycolysis and hepatocellular carcinoma progression by stabilizing PFKFB3 through deubiquitination.
Parvimonas micra promotes oral squamous cell carcinoma metastasis through TmpC-CKAP4 axis.
Apabetalone alleviates ligature-induced periodontitis by inhibiting M1 macrophage polarization via an immunometabolic shift.
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy.
Oxidative stress regulates the catalytic activity and mitochondrial localization of HK2 in trophoblast by regulating K346 lactylation.
Administration of Porphyromonas gingivalis in pregnant mice enhances glycolysis and histone lactylation/ADAM17 leading to cleft palate in offspring.
Integration of metabolomics and transcriptomics reveals the mechanism of TMEM30A downregulation induced FSGS podocyte injury.
PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer.
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis.
Fufang-Biejia-Ruangan tablet targeting both cancer-associated fibroblasts and tumor cells by HIPPO-PI3K/AKT cascades in intrahepatic cholangiocarcinoma treatment.
An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte.
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis.
An inflammation-associated lncRNA induces neuronal damage via mitochondrial dysfunction.
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
IER3 Facilitates Tumor Progression and Aberrant Glycolysis via Activating wnt/β-Catenin Pathway in Oral Squamous Cell Carcinoma.
HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming.
Ginsenoside RK1 Promotes Hepatic Stellate Cell Glycolysis-Mediated Ferroptosis by Activating the HK2/ACSL4/LPCAT3/ALOX5 Signaling Pathway.
Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells.
Adipocytes-induced ANGPTL4/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer.
Lactate inhibits mouse embryonic palatal mesenchyme cells chondrogenesis through AKT-PKM2 axis.
The dual mechanism of m(6)A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR.
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization.
AlkB Homolog 5 Regulates Hexokinase 2-Mediated Glycolysis and Participates in the Progression of Endometriosis.
Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer.
Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F.
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
Targeting SphK1/S1PR3 axis ameliorates sepsis-induced multiple organ injury via orchestration of macrophage polarization and glycolysis.
TIFA enhances glycolysis through E2F1 and promotes the progression of glioma.
Fatty acids promote migration of CD4(+) T cells through calcium release-activated calcium modulator ORAI1 sensitive glycolysis in dairy cows.
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.
IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1.
Functionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling.
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium-Doped Nanosystem to Enhance Chemotherapy and Immunotherapy.
Fatty Acid Oxidation-Glycolysis Metabolic Transition Affects ECM Homeostasis in Silica-Induced Pulmonary Fibrosis.
Micheliolide attenuates sepsis-induced acute lung injury by suppressing mitochondrial oxidative stress and PFKFB3-driven glycolysis.
LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study.
Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis.
Juglone targets MMP-1 to inhibit gastric cancer progression.
Exosomal miR-3126-5p derived from cancer-associated fibroblasts facilitates glycolysis to accelerate NSCLC progression by targeting KLF13 to activate the SH2B1/IRS1 axis.
Reactivating T cell immunity in Wnt-hyperactivated non-small cell lung cancer through a supramolecular droplet of carnosic acid and peptide.
SMARCA5 Cooperates With RSF1 to Promote Pathological Glycolysis and Chondrocyte Dysfunction in Osteoarthritis Through ATPase-Dependent Chromatin Regulation.
Integrative multi-omics analysis proposes a metabolic classification of gliomas: distinct metabolic states, immune infiltration, and prognosis.
[Morinda officinalis polysaccharide delays osteoarthritis mouse chondrocyte degeneration by modulating the glycolysis-pyroptosis axis via targeting the lncRNA XIST].
The SARS-CoV-2 nucleocapsid protein induces microglia senescence-mediated cognitive impairment via Glycolysis.
m6A-mediated regulation of ECA39 promotes renal fibrosis in chronic kidney disease by enhancing glycolysis and epithelial-mesenchymal transition.
Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation.
Activation of M1 macrophages promotes diabetic kidney disease by modulating glycolysis via HIF-1α-HK2 signaling pathway.
Targeting TSPAN1 promotes ferroptosis in endometrial cancer cells, reduces energy metabolism and inhibits malignant behavior.
miRNA-204-5p acts as a tumor suppressor in gastric cancer by inhibiting cell migration, invasion, and glycolysis via the RAB22A/PI3K/AKT axis.
O-GlcNAcylation of hexokinase 2 modulates mitochondrial dynamics and enhances the progression of lung cancer.
Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy.
Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor.
Polygala fallax Hemsl. ameliorated high glucose-induced podocyte injury by modulating mitochondrial mPTP opening through the SIRT1/PGC-1α pathway.
Activation of GPR35 by kynurenic acid inhibits IL-1β secretion in macrophages during CR-hvKP-induced pneumonia.
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.
The interaction between IL-33 and TRIM28 in the regulation of macrophage polarization in an ST2-independent manner.
A coregulatory influence map of glioblastoma heterogeneity and plasticity.
Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication.
The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma.
Angiotensin-(1-7) Modulates the Warburg Effect to Alleviate Inflammation in LPS-Induced Macrophages and Septic Mice.
PFKFB3 deprivation attenuates the cisplatin resistance via blocking its autophagic elimination in colorectal cancer cells.
The long noncoding RNA MIR4435-2HG enhances the migration, promotion, and glycolysis of nonsmall cell lung cancer cells by targeting the miR-371a-5p/SOX2/PI3K/Akt axis.
Circ_0004674 regulation of glycolysis and proliferation mechanism of osteosarcoma through miR-140-3p/TCF4 pathway.
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.
PGD: Shared gene linking polycystic ovary syndrome and endometrial cancer, influencing proliferation and migration through glycometabolism.
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis.
Exogenous thyroxine increases cardiac GLUT4 translocation in insulin resistant OLETF rats.
Endoplasmic reticulum stress is attenuated by glycolysis in lymphatic malformations.
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis.
Dapagliflozin attenuates AKI to CKD transition in diabetes by activating SIRT3/PGC1-α signaling and alleviating aberrant metabolic reprogramming.
Histones Methyltransferase NSD3 Inhibits Lung Adenocarcinoma Glycolysis Through Interacting with PPP1CB to Decrease STAT3 Signaling Pathway.
Tetradecyl 2,3-Dihydroxybenzoate Improves Cognitive Function in AD Mice by Modulating Autophagy and Inflammation Through IPA and Hsc70 Targeting.
Sini decoction-polysaccharide compound regulates proliferation, apoptosis, and glycolysis of liver cancer cells through PHLDA2/ANXA2.
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Quercetin alleviates liver fibrosis via regulating glycolysis of liver sinusoidal endothelial cells and neutrophil infiltration.
TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth.
STC2 knockdown inhibits cell proliferation and glycolysis in hepatocellular carcinoma through promoting autophagy by PI3K/Akt/mTOR pathway.
Downregulation of C1R promotes hepatocellular carcinoma development by activating HIF-1α-regulated glycolysis.
LncRNA MBNL1-AS1 knockdown increases the sensitivity of hepatocellular carcinoma to tripterine by regulating miR-708-5p-mediated glycolysis.
Dietary pectin and inulin: A promising adjuvant supplement for collagen-induced arthritis through gut microbiome restoration and CD4(+) T cell reconstitution.
Influenza A virus-induced glycolysis facilitates virus replication by activating ROS/HIF-1α pathway.
Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats.
Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment.
Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1.
Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.
Mechanism study of lncRNA RMRP regulating esophageal squamous cell carcinoma through miR-580-3p/ATP13A3 axis.
Flavokawain C inhibits glucose metabolism and tumor angiogenesis in nasopharyngeal carcinoma by targeting the HSP90B1/STAT3/HK2 signaling axis.
PRR34-AS1 promotes mitochondrial division and glycolytic reprogramming in hepatocellular carcinoma cells through upregulation of MIEF2.
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.
Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation.
Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis.
Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency.
Mucous cell histopathology and label-free quantitative proteomic analysis of skin mucus in fat greenling (Hexagrammos otakii) infected with Vibrio harveyi.
p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration.
METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer.
Hypoxia-mediated attenuation of EGLN2 inhibition of the NF-κB signaling pathway leads to the formation of a loop between HIF-1α and MUC1-C promoting chemoresistance in bladder cancer.
DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway.
β-catenin mediates monocrotaline-induced pulmonary hypertension via glycolysis in rats.
Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats.
Sanguinarine Induces Necroptosis of HCC by Targeting PKM2 Mediated Energy Metabolism.
The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis.
Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency.
Identification of hub glycolysis-related genes in acute myocardial infarction and their correlation with immune infiltration using bioinformatics analysis.
OCT1 regulates the migration of colorectal cancer cells by acting on LDHA.
Carrier-free nanodrug targeting glucose metabolism for enhanced rheumatoid arthritis treatment.
Cryptotanshinone suppresses ovarian cancer via simultaneous inhibition of glycolysis and oxidative phosphorylation.
Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism.
Fluvoxamine inhibits Th1 and Th17 polarization and function by repressing glycolysis to attenuate autoimmune progression in type 1 diabetes.
AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.
E. Coli LPS-induced calcium signaling regulates the expression of hypoxia-inducible factor 1α in periodontal ligament fibroblasts in a non-hypoxia-dependent manner.
Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis.
Cepharanthine inhibits African swine fever virus replication by suppressing AKT-associated pathways through disrupting Hsp90-Cdc37 complex.
YAP1 Overexpression Enhances the Aerobic Glycolysis Process via Suppression of EGLN2 in Pancreatic Ductal Adenocarcinoma.
Activation of ferritin light chain (FTL) by transcription factor salmonella pathogenicity island 1 modulates glycolysis to drive metastasis of ovarian cancer cells.
Dynamic changes of protein lactylation and their correlations with the glycolytic process during the postmortem acidification of broiler breast.
Molecular and Clinical Characterization of a Founder Mutation Causing G6PC3 Deficiency.
Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia.
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1.
Antitumorigenic potential of Lactobacillus-derived extracellular vesicles: p53 succinylation and glycolytic reprogramming in intestinal epithelial cells via SIRT5 modulation.
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
N(6)-methyladenosine-modified SRPK1 promotes aerobic glycolysis of lung adenocarcinoma via PKM splicing.
CircNAP1L4 regulates pulmonary artery smooth muscle cell proliferation via the NAP1L4-mediated super-enhancer-driven glycolysis gene hexokinase II (HK II) in pulmonary hypertension.
Mitochondria-Targeted Multifunctional Nanoprodrugs by Inhibiting Metabolic Reprogramming for Combating Cisplatin-Resistant Lung Cancer.
The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.
Age-Related Gut Microbiota Transplantation Disrupts Myocardial Energy Homeostasis and Induces Oxidative Damage.
Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.
Circular RNA COL1A1 promotes Warburg effect and tumor growth in nasopharyngeal carcinoma.
Metabolic reprogramming of cancer-associated fibroblasts in pancreatic cancer contributes to the intratumor heterogeneity of PET-CT.
Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.
METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury.
HOXA1 promotes aerobic glycolysis and cancer progression in cervical cancer.
Osteogenic microenvironment affects palatal development through glycolysis.
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement.
hsa_circ_0003596, as a novel oncogene, regulates the malignant behavior of renal cell carcinoma by modulating glycolysis.
Single-cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell-type-specific mechanisms.
LINC02774 inhibits glycolysis in glioma to destabilize HIF-1α dependent on transcription factor RP58.
IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.
Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via a nuclear receptor (Nur77)-mediated epigenetic regulation of glutaminase 1.
LDHA and LDHB overexpression promoted the Warburg effect in malignantly transformed GES-1 cells induced by N-nitroso compounds.
Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia.
Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes.
Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis.
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion.
The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells.
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.
Butyrate prevents the migration and invasion, and aerobic glycolysis in gastric cancer via inhibiting Wnt/β-catenin/c-Myc signaling.
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling.
Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice.
Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism.
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC.
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis.
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4.
Exploratory metabolomic analysis based on UHPLC-Q-TOF-MS/MS to study hypoxia-reoxygenation energy metabolic alterations in HK-2 cells.
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells.
Effect of chronic heat stress on the carbonylation of glycolytic enzymes in breast muscle and its correlation with the growth performance of broilers.
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
Relationship between the expression of PD-L1 and (18)F-FDG uptake in pancreatic ductal adenocarcinoma.
Experimental Study of Warburg Effect in Keloid Nodules: Implication for Downregulation of miR-133b.
Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis.
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.
Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism.
ErbB2-upregulated HK1 and HK2 promote breast cancer cell proliferation, migration and invasion.
Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer's Disease.
Cordycepin Inhibits the Growth of Hepatocellular Carcinoma by Regulating the Pathway of Aerobic Glycolysis.
Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS.
Mechanism of selenomethionine inhibiting of PDCoV replication in LLC-PK1 cells based on STAT3/miR-125b-5p-1/HK2 signaling.
Effects of Glycolysis-Related Genes on Prognosis and the Tumor Microenvironment of Hepatocellular Carcinoma.
Number 2 Feibi Recipe Inhibits H(2)O(2)-Mediated Oxidative Stress Damage of Alveolar Epithelial Cells by Regulating the Balance of Mitophagy/Apoptosis.
Singapore Grouper Iridovirus Induces Glucose Metabolism in Infected Cells by Activation of Mammalian Target of Rapamycin Signaling.
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth.
AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model.
Changes in the Expression of MIF and Other Key Enzymes of Energy Metabolism in the Myocardia of Broiler Chickens with Ascites Syndrome.
Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1.
A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.
Fibroblast growth factor 7 alleviates myocardial infarction by improving oxidative stress via PI3Kα/AKT-mediated regulation of Nrf2 and HXK2.
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis.
HMGA2 mediates Cr (VI)-induced metabolic reprogramming through binding to mitochondrial D-Loop region.
Curcumin attenuates Cr (VI)-induced cell growth and migration by targeting autophagy-dependent reprogrammed metabolism.
N-phenethyl-5-phenylpicolinamide alleviates inflammation in acute lung injury by inhibiting HIF-1α/glycolysis/ASIC1a pathway.
Jumonji-C domain-containing protein 5 suppresses proliferation and aerobic glycolysis in pancreatic cancer cells in a c-Myc-dependent manner.
VLCAD inhibits the proliferation and invasion of hepatocellular cancer cells through regulating PI3K/AKT axis.
Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/β-catenin signaling pathway.
Berberine Modulates Macrophage Activation by Inducing Glycolysis.
A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells.
MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression.
RETRACTED: PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages.
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1.
Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex.
Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells.
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Metabolic Reprogramming in Response to Alterations of Mitochondrial DNA and Mitochondrial Dysfunction in Gastric Adenocarcinoma.
PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis.
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.
Cocktail strategy based on a dual function nanoparticle and immune activator for effective tumor suppressive.
PVT1/miR-145-5p/HK2 modulates vascular smooth muscle cells phenotype switch via glycolysis: The new perspective on the spiral artery remodeling.
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
Long noncoding RNA CERS6-AS1 modulates glucose metabolism and tumor progression in hepatocellular carcinoma by promoting the MDM2/p53 signaling pathway.
The expression of Hexokinase 2 and its hub genes are correlated with the prognosis in glioma.
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Role of Proximal Intestinal Glucose Sensing and Metabolism in the Blood Glucose Control in Type 2 Diabetic Rats After Duodenal Jejunal Bypass Surgery.
U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells.
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.
Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.
CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner.
Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.
Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2.
Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation.
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.
The novel prognostic risk factor STC2 can regulate the occurrence and progression of osteosarcoma via the glycolytic pathway.
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy.
Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation.
Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers.
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.
Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease.
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway.
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
Mitochondrial Voltage-Dependent Anion Channel 1-Hexokinase-II Complex-Targeted Strategy for Melanoma Inhibition Using Designed Multiblock Peptide Amphiphiles.
An Experimentally Induced Mutation in the UBA Domain of p62 Changes the Sensitivity of Cisplatin by Up-Regulating HK2 Localisation on the Mitochondria and Increasing Mitophagy in A2780 Ovarian Cancer Cells.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
JAK2(V617F) Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Ginsenoside Rh2 inhibits HeLa cell energy metabolism and induces apoptosis by upregulating voltage‑dependent anion channel 1.
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes.
Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in Promoting Gastric Cancer Progression.
STAT3 Activation-Induced Fatty Acid Oxidation in CD8(+) T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth.
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression.
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Up-regulated ANP32E promotes the thyroid carcinoma cell proliferation and migration via activating AKT/mTOR/HK2-mediated glycolysis.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Modulating the tumor immune microenvironment with sunitinib malate supports the rationale for combined treatment with immunotherapy.
Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer.
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.
Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2.
Fructose 1,6-Bisphosphatase 1 Expression Reduces (18)F-FDG Uptake in Clear Cell Renal Cell Carcinoma.
Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis.
Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.
LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis.
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Hexokinase 2 dimerization and interaction with voltage-dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer.
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer.
Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria.
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway.
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer.
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
The long non-coding RNA SNHG1 promotes glioma progression by competitively binding to miR-194 to regulate PHLDA1 expression.
Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis.
Bufalin inhibits glycolysis-induced cell growth and proliferation through the suppression of Integrin β2/FAK signaling pathway in ovarian cancer.
Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer.
Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α.
Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation.
Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by (1)H NMR Based Metabolic Profiling.
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.
Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.
MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer.
Nalmefene attenuates malignant potential in colorectal cancer cell via inhibition of opioid receptor.
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
AAED1 modulates proliferation and glycolysis in gastric cancer.
Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Dahuang Zhechong Pill Combined with Doxorubicin Induces Cell Death through Regulating Energy Metabolism in Human Hepatocellular Carcinoma Cells.
Fructose-1,6-Bisphosphatase 1 Reduces (18)F FDG Uptake in Hepatocellular Carcinoma.
Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma.
Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice.
Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes.
Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy.
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer.
PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT.
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.
Guo X, Lin Y, Jiang Y, Wang M, Li Y, Gao Y, Chen B, Bao Z, Tian H, Chu X, Zhang Z, Shao J, Zhang F, Wang H, Xuan J, Xu X, Zheng S
International journal of biological sciences 2026;22(3):1648-1673
International journal of biological sciences 2026;22(3):1648-1673
Targeting Myeloid FoxO1 Ameliorates Sepsis-induced Intestinal Injury by Modulating Tim4(+) Macrophage Glycolysis.
Ni J, Zhang R, Pu Y, He Y, Hu W, Su L, Hou Y, Dou H
International journal of biological sciences 2026;22(1):239-257
International journal of biological sciences 2026;22(1):239-257
Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway.
Qiao X, Xue D, Hu Z, Wang H, Mu L
Toxicology and applied pharmacology 2026 May;510:117775
Toxicology and applied pharmacology 2026 May;510:117775
Programmable bacteria-driven biohybrid triggers spatiotemporal-controlled STING activation to potentiate cuproptosis-based cancer therapy.
Kang R, Pan X, Zhou X, Pang Y, Shen Z, Luo L, Liu F, Yu S, Shen Q
Biomaterials 2026 May;328:123893
Biomaterials 2026 May;328:123893
Zuoguiyin modulates M2 macrophage polarization to inhibit glycolysis in esophageal squamous cell carcinoma.
Wang Y, Guo J, Zhou L, Yuan J, Huang R, Xing T, Chang L, Wu Z, Li J, Huang M
Journal of ethnopharmacology 2026 May 10;362:121404
Journal of ethnopharmacology 2026 May 10;362:121404
Ginsenoside Re regulates PFKFB3-mediated glycolysis to inhibit endothelial cell migration to ameliorate atherosclerosis.
Wang Z, Mou J, Han W, Liu S, Wang M, Sun G
Journal of ginseng research 2026 Mar;50(2):100924
Journal of ginseng research 2026 Mar;50(2):100924
Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells.
Balasundaram N, Erdem A, Sharda A, Daniels VW, Chea PL, Leguay F, Liu Y, Keibler MA, Vidoudez C, Lane AA, Vertommen D, Casteur H, Laurent MR, Trauger SA, Stephanopoulos G, Scadden DT, van Gastel N
bioRxiv : the preprint server for biology 2026 Mar 3;
bioRxiv : the preprint server for biology 2026 Mar 3;
Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.
Li F, Li H, Jia Y, Ou L, Fang Y, Pan L, Liu H, Ning B
Journal of translational medicine 2026 Mar 17;24(1)
Journal of translational medicine 2026 Mar 17;24(1)
Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular Dementia Based on Multi-Omics Approach.
Xiao T, Tao J, Tan J, Yi X, Wang Z, Duan X
Biomolecules 2026 Mar 11;16(3)
Biomolecules 2026 Mar 11;16(3)
Echinacoside modulates PARP14-GLUD1 axis to mediate energy metabolism reprogramming and mitochondrial function in diminished ovarian reserve.
Liang H, Shu C, Huang Z, Yuan S, Yang Q, Chen S, Zhou X, Yang N, Xiang X, Xia Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158100
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158100
Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
Liu Y, Yang X, Qin M, Chen W, Liu C, Jiang W, Wang Y, Tan S, Sun H, Chen J, Sun H, He S
Journal of ethnopharmacology 2026 Jun 28;365:121554
Journal of ethnopharmacology 2026 Jun 28;365:121554
Neuronal ACVR1-mediated H3K18 lactylation drives NLRP3 pyroptosis to sustain neuropathic pain via metabolic-epigenetic coupling.
Zhao X, Zhang X, Li Y, Fu C, Yuan L, Cong T, Niu Z
Neurobiology of disease 2026 Jun 15;224:107397
Neurobiology of disease 2026 Jun 15;224:107397
Curcumin inhibits colorectal cancer progression by regulating MDH2-mediated glycolysis and NAD(+) metabolism.
Zhao Y, Qin H, Sun W, Chen Y, Wang R, Li C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jul;213:116074
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jul;213:116074
Propranolol accelerates adipogenesis and inhibits endothelium differentiation of HemSCs via suppressing HK2 mediated glycolysis.
Zhu T, Wang P, Wang R, Tong G, Sun Y, Yang S, Zhou X, Mou D, Zhong W, Cai Y
Pediatric research 2026 Jan;99(1):351-361
Pediatric research 2026 Jan;99(1):351-361
USP28 Promotes Osimertinib Resistance in H1975 NSCLC Cells by Deubiquitinating and Stabilizing SIRT1.
Fan HS, Li XM, Gu JQ, Wang HF, Zhang ZJ
The Kaohsiung journal of medical sciences 2026 Jan;42(1):e70095
The Kaohsiung journal of medical sciences 2026 Jan;42(1):e70095
pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy.
Gong L, Li S, Sun J, Liu K, Wang S, Ji M, Hou P, Yan L, Yang D, Liu D
Acta pharmaceutica Sinica. B 2026 Jan;16(1):539-554
Acta pharmaceutica Sinica. B 2026 Jan;16(1):539-554
Notopterol attenuates synovitis via α7nAChR-dependent metabolic reprogramming of macrophage polarisation.
Chen X, Zhang C, Ye Y, Zhuang Y, Huang M, Yu H, Qin Z, Chen Y, Hong Z, Tu H, Wang Y, Wang Z, Wang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157684
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157684
ULK2 suppresses glycolysis to attenuate cisplatin resistance in ovarian cancer organoid via c-Jun phosphorylation.
Chen W, Chen X, Wang L, Qu Y, Zhao J, Sun H
Science progress 2026 Jan-Mar;109(1):368504261421695
Science progress 2026 Jan-Mar;109(1):368504261421695
Maternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase.
Miao Y, Meng Z, Chen S, Li X, Fang T, Deng X, Sun B, Chen L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Jan 31;40(2):e71426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Jan 31;40(2):e71426
Ptbp2 Alleviates Neuroinflammation and Blood-brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke.
Xu W, Li L, Zhou M, Zhang C, Zhang X
Molecular neurobiology 2026 Jan 30;63(1):408
Molecular neurobiology 2026 Jan 30;63(1):408
N-nitrosodimethylamine increased glucose production by promoting hyperglycemia in hepatocyte via AMPK signaling pathway in vivo and in vitro.
Wang W, Xi S, Wang Y
Drug and chemical toxicology 2026 Jan 3;:1-12
Drug and chemical toxicology 2026 Jan 3;:1-12
Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress.
Yang S, Wu T, Cao Z, Chen Z, Ma Y, Wang T, Qian L, Huang X
Apoptosis : an international journal on programmed cell death 2026 Jan 23;31(2):55
Apoptosis : an international journal on programmed cell death 2026 Jan 23;31(2):55
(18)F-FDG PET imaging reveals GW4869's suppression of glioblastoma malignant progression and reversal of TMZ chemoresistance via glucose metabolic phenotype remodeling.
Han F, Xu Y, Qian C, Meng B, Mo X, Chen Y, Zhu X, He C, Zhou M, Zhang Z
Journal of translational medicine 2026 Jan 21;24(1):245
Journal of translational medicine 2026 Jan 21;24(1):245
Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis.
Jiang Q, Xu R, Cheng J, Shi Y, Zhu T, Yu M, Cui X, Lin C
Journal of pharmaceutical and biomedical analysis 2026 Jan 15;268:117232
Journal of pharmaceutical and biomedical analysis 2026 Jan 15;268:117232
Porcine epidemic diarrhea virus promotes viral replication via ROS/HIF-1α-mediated glycolysis.
Xu Y, Zhang J, Yin C, Liu L, Wang Z, Fu S, Fan R, Zhao Y, Miao J
Redox biology 2026 Feb;89:104008
Redox biology 2026 Feb;89:104008
High-Fat Diet Promotes Glycolysis in Hepatocellular Carcinoma by Suppressing Hepatic Kisspeptin Signaling in Mice.
Zhao R, Nie L, Shi Y, Jin L, Pan Y, Zhang X, Wang Z, He M, Zhang G, Yuan Q, Xia T, Wang S, Yang J, Yang W, Yuan D
Molecular carcinogenesis 2026 Feb;65(2):246-257
Molecular carcinogenesis 2026 Feb;65(2):246-257
ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells.
Wang H, Luo K, Li S, Jin D, Ou L, Liu C, Wu Q
Journal of bioenergetics and biomembranes 2026 Feb 15;58(1)
Journal of bioenergetics and biomembranes 2026 Feb 15;58(1)
Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar.
Yuan Y, Xiao Y, Zou J, Luo L, Li M, Shen K, Wei L, Zhang Y, Wang P, Chen Y, Zhuo S, Zhang H, Song S, Jia Y, Wang K, Jiang S, Guan H, Hu D
Nature communications 2026 Feb 12;17(1)
Nature communications 2026 Feb 12;17(1)
Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis.
Wu Q, Miao J, Chen Y, Yang Y, Liang H, Yu C, Wang C, Tu Y, Wu Y, Xu Y, Yang X, Kwan KYH, Shi C, Wang X, Xu J, Jin H
Bioactive materials 2026 Apr;58:1-18
Bioactive materials 2026 Apr;58:1-18
Unlocking an Efficient SOD-to-CAT Catalytic Relay in a MOF Nanozyme via Dopamine-Driven Interfacial Nanoreconstruction for Osteoarthritis Therapy.
Li Z, Wu B, Li W, Marsili E, Tang K, Sun K, Cao Z, Zhang Y, Huang H, Li X, Wang G
Advanced materials (Deerfield Beach, Fla.) 2026 Apr;38(19):e72747
Advanced materials (Deerfield Beach, Fla.) 2026 Apr;38(19):e72747
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
Tai C, Ling C, Yang Y, Mo N, Yao C, Lv S, Zhang B, Wang H, Chen C
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
Integrative metabolomics and lipidomics reveal Jian-Pi-Yi-Shen formula improves adenine-induced CKD rats by regulating intrarenal glycolipid metabolism.
Liu X, Li H, Xu Y, Peng Y, Wu S, Ye X, Yang Y, Lu J
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 1;1273:124957
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 1;1273:124957
Ubiquitin C-terminal hydrolase L5 promotes the development of renal cell carcinoma through the glycolysis mediated by the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
Ruan L, Li S, Xu L
CytoJournal 2025;22:99
CytoJournal 2025;22:99
SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity.
Che J, Qiu Z, Hou H, Li Y, He L, Sun J, Zhang S, Li M, Pan S, Zhang W, Niu Y
Journal of tissue engineering and regenerative medicine 2025;2025:6659059
Journal of tissue engineering and regenerative medicine 2025;2025:6659059
Layered Double Hydroxide Nanoparticles Loaded with Resveratrol Inhibit Glycolysis and Show Efficacy in the Treatment of Breast Cancer.
Geng C, Yan L, Li Y, Li H, Ji Y, Xiao Y, Wang Z, Chen X, Chen C, Yang Q, Tang B, Wang W
International journal of nanomedicine 2025;20:3423-3444
International journal of nanomedicine 2025;20:3423-3444
Enhancing Quercetin's Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema.
Lin L, Shen B, Cui J, Gao Y, Wang L, Yang T, Weng J, Lai C, Tang X, Xiao C, Shen X, Gao Y
Drug design, development and therapy 2025;19:9151-9167
Drug design, development and therapy 2025;19:9151-9167
Artemether ameliorates type 1 diabetes mellitus by modulating glycolipid metabolism in skeletal muscle.
Dong Y, Fu Q, Zhang Y, Weng W, Han P, Cai Y, Sun H
American journal of translational research 2025;17(8):5871-5884
American journal of translational research 2025;17(8):5871-5884
Parishin E from ginger-processed Gastrodia elata Bl. alleviates rheumatoid arthritis by regulating histone 3 lactylation at H3K18la and H3K27la sites.
Liu X, Pan Y, Deng C, Zhu M, Guo D, Wu J, Feng F, Pan L, Wang C, Xu K
Frontiers in pharmacology 2025;16:1682504
Frontiers in pharmacology 2025;16:1682504
Panoramic view of MDH1: driving cancer progression and shaping the tumor immune microenvironment.
Lou Y, Lou Y, Cheng Y, Xu B, Chen H, Dai Y
Frontiers in immunology 2025;16:1631449
Frontiers in immunology 2025;16:1631449
Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progression.
Liu Y, Li J, Cao Y, Lv M
Frontiers in oncology 2025;15:1583752
Frontiers in oncology 2025;15:1583752
Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells.
Fang P, Li S, Lu ZQ, Xia DL, Xu MM, Pan JJ, Fu L, Sun GY, You QH
Burns & trauma 2025;13:tkaf056
Burns & trauma 2025;13:tkaf056
SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome.
Yan S, Qu B, Chen Y, Wu Q, Ding J, Qiu H
Frontiers in cell and developmental biology 2025;13:1585987
Frontiers in cell and developmental biology 2025;13:1585987
sPLA2-IB and PLA2R Mediate Aberrant Glucose Metabolism in Podocytes via Hyperactivation of the mTOR/HIF-1α Pathway.
Bao J, Dai B, Yang L, Liu Z, Jin Y, Zhao H, Pan Y
Cell biochemistry and biophysics 2025 Sep;83(3):3341-3351
Cell biochemistry and biophysics 2025 Sep;83(3):3341-3351
HBV Precore G1896A Mutation Promotes Malignancy of Hepatocellular Carcinoma by Activating Endoplasmic Reticulum Stress to Enhance Aerobic Glycolysis.
Zhao B, Qiao H, Gao Z, Zhao Y, Wang W, Cui Y, Li F, Wang Y, Guo Z, Chuai X, Chiu S
MedComm 2025 Sep;6(9):e70365
MedComm 2025 Sep;6(9):e70365
ZMYND8 promotes the Warburg effect and tumorigenesis through c-Myc activation in pancreatic cancer.
Liu H, Zhao Z, Wu C, Chen J, He Z, Jiang K
Oncogene 2025 Sep;44(34):3083-3095
Oncogene 2025 Sep;44(34):3083-3095
Complement C1q inhibits the immune escape of mycobacterium tuberculosis associated with macrophage inflammation levels and glycolytic activation.
Liu Y, Wang J, Pu Y, Tang S
Microbial pathogenesis 2025 Sep;206:107757
Microbial pathogenesis 2025 Sep;206:107757
Self-Assembling Amphiphilic Peptides Target the VDAC1-Hexokinase-II Complex to Induce Apoptosis in Cervical Carcinoma Cells.
Sun W, Angelova A, Han X, Wang X, Angelov B, Chen Q, Li N, Zou A
Journal of medicinal chemistry 2025 Sep 25;68(18):18857-18868
Journal of medicinal chemistry 2025 Sep 25;68(18):18857-18868
Cancer-associated fibroblast derived CXCL14 drives cisplatin chemoresistance by enhancing nucleotide excision repair in bladder cancer.
Li T, Zhu K, Tong H, Sun Y, Zhu J, Qin Z, Chen J, Wu L, Zhang X, Wang A, Gou X, Yin H, He W
Journal of experimental & clinical cancer research : CR 2025 Sep 2;44(1):265
Journal of experimental & clinical cancer research : CR 2025 Sep 2;44(1):265
3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay.
Wu D, Guan X, Yang T, Yan J, Zhu B, Zhou J, Guo Y, Lu Y
Materials today. Bio 2025 Oct;34:102176
Materials today. Bio 2025 Oct;34:102176
Astragaloside IV alleviates radiation-induced heart disease by regulating energy metabolism.
Li Q, Zhang S, Li Y, Yao N, Feng Y, Yang G, Wang Y, Dai S, Cheng S, Zhou T, Wang X, Zhang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157135
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157135
Microcystin-LR disrupts ovarian granulosa cell glycolysis via GSK3β-Mediated HK2 mitochondrial dissociation: Evidence from integrated In Vivo and In Vitro models.
Yuan J, Li X, Yan S, Luo C, Xian S, Li Y, Wu J
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109028
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109028
BCL-2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in AML.
Peng X, Li Y, Tang F, Ma Y, Bai J, Li L, Zhang L
Cancer science 2025 Oct;116(10):2657-2676
Cancer science 2025 Oct;116(10):2657-2676
Skullcapflavone II Suppresses Colorectal Cancer by Inhibiting the HIF-1α-Glycolysis Pathway.
Yang S, Hu W, Xin X, Zhang G
Chemical biology & drug design 2025 Oct;106(4):e70184
Chemical biology & drug design 2025 Oct;106(4):e70184
Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production.
Chen Z, Liao J, Zhu C, Chang R, Liang H, Ding Z, Huang Z, Chen X, Liang J, Zhang B
Cancer research 2025 Oct 15;85(20):3930-3948
Cancer research 2025 Oct 15;85(20):3930-3948
TRIB3 promotes endometrial cancer progression through interacting with E2F1 and enhancing PKM2-mediated tumor glycolysis.
Geng F, Wang Y, Cui G, Fan M
Gynecologic oncology 2025 Nov;202:41-52
Gynecologic oncology 2025 Nov;202:41-52
Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia.
Fang Y, Zhang T, Xu K, Wang L, He J, Liao Y, Yuan N, Tang J
Brain, behavior, and immunity 2025 Nov;130:106111
Brain, behavior, and immunity 2025 Nov;130:106111
eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring.
Mittal S, Nenwani M, Pulikkal Kadamberi I, Kumar S, Animasahun O, George J, Tsaih SW, Gupta P, Singh M, Geethadevi A, Dey C, Meurs N, Shankaran A, Chaluvally Raghavan P, Nagrath D, Pradeep S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e06307
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e06307
IL17A Mediates Glycolysis-Dependent Primary Angiogenesis and Exacerbates Ischemic Stroke Injury.
Xu Q, Lian Z, Ye Y, Wang J, Shafiq Z, Xiong X, Cai Q, Gu L
Molecular neurobiology 2025 Nov 25;63(1):169
Molecular neurobiology 2025 Nov 25;63(1):169
Astragalin rescues Cadmium-induced cognitive decline by revering glial metabolic reprogramming and neuroinflammation via the mTOR/HIF-1α axis.
Huang Q, Wang J, Cao MM, Ma HY, Qin XY, Hu Y, Lan R
Neuroscience 2025 Nov 19;588:31-39
Neuroscience 2025 Nov 19;588:31-39
Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia.
Sun T, Yu H, Zhang D, Zhang D, Li D, Fu J
Redox biology 2025 May;82:103586
Redox biology 2025 May;82:103586
Effective-compounds of Jinshui Huanxian Formula acts as an SRC inhibitor to inhibit HK2-mediated H3K18 lactation and improve pulmonary fibrosis.
Zheng J, Du Y, Shao W, Li J, Zhao P, Zhang Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156628
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156628
The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis.
Zhao L, Chen X, Zhang Y, Cen Y, Zhu T, Wang L, Xia L, Li Y, Cheng X, Xie X, Lu W, Xu J
Journal of translational medicine 2025 May 4;23(1):506
Journal of translational medicine 2025 May 4;23(1):506
Qingyihuaji formula reprograms metabolism to suppress pancreatic cancer growth and progression through LINC00346-OMA1-ATF4 signaling.
Shi W, Wang Z, Yu Z, Shen Y, Xin W, Chen W
Journal of ethnopharmacology 2025 May 28;348:119893
Journal of ethnopharmacology 2025 May 28;348:119893
Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic ductal adenocarcinoma.
Chen Y, Zhang F, Dai S, Zhao J, Cai W, Zhang K, Liao X, Chen L
BMC cancer 2025 May 21;25(1):913
BMC cancer 2025 May 21;25(1):913
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Li M, Zhang W, Zhang M, Li L, Yao Y, Qin Y, Wang D, Yan G, Qiao Y, Tang C
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Hu Y, Kuang M, Song H, Tan Y, Zhou F, Pei G, Jiao L
European journal of pharmacology 2025 May 15;995:177353
European journal of pharmacology 2025 May 15;995:177353
Pubescenoside D Ameliorates Myocardial Ischemia-Reperfusion Injury via Preventing the Dissociation of HK2 and Promoting Mitophagy by Targeting GSK-3β.
Xiao J, Wu P, Wang L, Luo J, Wang Y, Cheng Y, Zhang R, Liu Z
Phytotherapy research : PTR 2025 Mar;39(3):1578-1591
Phytotherapy research : PTR 2025 Mar;39(3):1578-1591
Knockdown of SESN2 Exacerbates Cerebral Ischemia-Reperfusion Injury Through Enhancing Glycolysis via the mTOR/HIF-1α Pathway.
Wang Z, Huang Y, Zhang Y, Zhu H, Amin MR, Chen R, Gu L, Xiong X
CNS neuroscience & therapeutics 2025 Mar;31(3):e70314
CNS neuroscience & therapeutics 2025 Mar;31(3):e70314
USP27 promotes glycolysis and hepatocellular carcinoma progression by stabilizing PFKFB3 through deubiquitination.
Xie L, Song D, Ouyang Z, Ning Y, Liu X, Li L, Xia W, Yang Y
Cellular signalling 2025 Mar;127:111585
Cellular signalling 2025 Mar;127:111585
Parvimonas micra promotes oral squamous cell carcinoma metastasis through TmpC-CKAP4 axis.
Qi H, Gao H, Li M, Sun T, Gu X, Wei L, Zhi M, Li Z, Fu D, Liu Y, Wei Z, Dou Y, Feng Q
Nature communications 2025 Mar 7;16(1):2305
Nature communications 2025 Mar 7;16(1):2305
Apabetalone alleviates ligature-induced periodontitis by inhibiting M1 macrophage polarization via an immunometabolic shift.
Bian T, Li H, Liu H, Guo M, Zhang Y, Hu P, Chen M
International immunopharmacology 2025 Mar 26;150:114279
International immunopharmacology 2025 Mar 26;150:114279
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
Peng C, Lei P, Qi H, Zhu Q, Huang C, Fu J, Zhao C
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy.
Zhao Q, Cai D, Xu H, Gao Y, Zhang R, Zhou X, Chen X, Chen S, Wu J, Peng W, Yuan S, Li D, Li G, Nan A
Molecular cancer 2025 Mar 17;24(1):82
Molecular cancer 2025 Mar 17;24(1):82
Oxidative stress regulates the catalytic activity and mitochondrial localization of HK2 in trophoblast by regulating K346 lactylation.
Chen Z, Wan L, Wu M, Zhao Y, Huang H, He Q, Wang Y, Luo Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70429
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70429
Administration of Porphyromonas gingivalis in pregnant mice enhances glycolysis and histone lactylation/ADAM17 leading to cleft palate in offspring.
Zhao X, Zheng X, Wang Y, Chen J, Wang X, Peng X, Yuan D, Liu Y, Wang Z, Du J
International journal of oral science 2025 Mar 13;17(1):18
International journal of oral science 2025 Mar 13;17(1):18
Integration of metabolomics and transcriptomics reveals the mechanism of TMEM30A downregulation induced FSGS podocyte injury.
Hou Y, Chen S, Li Y, Huang L, Zhang H, Yu M, Xiong L, Zhong X, Wang L, Zhu X, Li G, Peng L
American journal of physiology. Renal physiology 2025 Mar 1;328(3):F389-F405
American journal of physiology. Renal physiology 2025 Mar 1;328(3):F389-F405
PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer.
Wu X, Wang B, Hou Y, Fang Y, Jiang Y, Song Y, Liu Y, Jin C
Biomolecules 2025 Mar 1;15(3)
Biomolecules 2025 Mar 1;15(3)
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.
Zhou Y, Chen W, Feng S, Liu S, Chen C, Yao B, Shen XL
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1440-1452
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1440-1452
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis.
Tu X, Lin W, Zhai X, Liang S, Huang G, Wang J, Jia W, Li S, Li B, Cheng B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156750
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156750
Fufang-Biejia-Ruangan tablet targeting both cancer-associated fibroblasts and tumor cells by HIPPO-PI3K/AKT cascades in intrahepatic cholangiocarcinoma treatment.
Xu Y, Li X, Cui M, Pan T, Zheng S, Shang Z, Yin D, Xu Y, Yang Z, Wang J, Song X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156690
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156690
An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte.
Leng X, Yang Y, Jiang T, Zheng J, Zhang L, Huang J, Xu H, Fang M, Li X, Wang Z, Ge M, Lin H
Advanced healthcare materials 2025 Jun;14(16):e2405174
Advanced healthcare materials 2025 Jun;14(16):e2405174
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Chen Y, Yan Q, Ruan S, Cui J, Li Z, Zhang Z, Yang J, Fang J, Liu S, Huang S, Hou B, Zhang C
Cell reports 2025 Jun 24;44(6):115774
Cell reports 2025 Jun 24;44(6):115774
OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis.
Jing G, Gong H, Wang H, Zuo J, Wu D, Liu H, Wang X, Yuan M, Xia Y, Du T, Liu W, Wu X, Song X
Journal of neuroinflammation 2025 Jun 11;22(1):154
Journal of neuroinflammation 2025 Jun 11;22(1):154
An inflammation-associated lncRNA induces neuronal damage via mitochondrial dysfunction.
Olazagoitia-Garmendia A, Rojas-Márquez H, Trobisch T, Moreno-Castro C, Rodriguez Etxebarria A, Mentxaka J, Tripathi A, Yang B, Martin Ruiz I, Anguita J, Meana JJ, Ding Y, Dutta R, Schirmer L, Igoillo-Esteve M, Santin I, Castellanos-Rubio A
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102533
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102533
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
Li Q, Huang Y, Ban T, Chen K, Zhen X, Dai Q, Zhang G
Neuropharmacology 2025 Jun 1;270:110374
Neuropharmacology 2025 Jun 1;270:110374
IER3 Facilitates Tumor Progression and Aberrant Glycolysis via Activating wnt/β-Catenin Pathway in Oral Squamous Cell Carcinoma.
Yin C, Miao Y, Lu W, Liu Z
Advanced biology 2025 Jul;9(7):e2400564
Advanced biology 2025 Jul;9(7):e2400564
HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming.
Liu J, Wu X, Yin Q, Zhang L, Liu K, Huang K, Xu J, Li X, Lin B, Zhu M, Li M
Journal of cellular and molecular medicine 2025 Jul;29(14):e70722
Journal of cellular and molecular medicine 2025 Jul;29(14):e70722
Ginsenoside RK1 Promotes Hepatic Stellate Cell Glycolysis-Mediated Ferroptosis by Activating the HK2/ACSL4/LPCAT3/ALOX5 Signaling Pathway.
Xia Z, Wang Y, Zhao Q, Deng M, Li C, Zeng Y, Xu J, Ying H, Zhu D, Zhang X, Wu X, Cai W, Zhou R, Yu F
Journal of agricultural and food chemistry 2025 Jul 9;73(27):17205-17218
Journal of agricultural and food chemistry 2025 Jul 9;73(27):17205-17218
Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells.
Li F, Liu X, Bai N, Li Y, Hou M, Hou Y, Liu Y, Wang X, He Q, Li J
European journal of pharmacology 2025 Jul 5;998:177519
European journal of pharmacology 2025 Jul 5;998:177519
Adipocytes-induced ANGPTL4/KLF4 axis drives glycolysis and metastasis in triple-negative breast cancer.
Yin D, Fang N, Zhu Y, Bao X, Yang J, Zhang Q, Wang R, Huang J, Wu Q, Ma F, Wei X
Journal of experimental & clinical cancer research : CR 2025 Jul 4;44(1):192
Journal of experimental & clinical cancer research : CR 2025 Jul 4;44(1):192
Lactate inhibits mouse embryonic palatal mesenchyme cells chondrogenesis through AKT-PKM2 axis.
Meng M, Zhao X, Zheng X, Wang X, Peng X, Wang Z, Wang S, Guo C, Du J
BMC oral health 2025 Jul 31;25(1):1289
BMC oral health 2025 Jul 31;25(1):1289
The dual mechanism of m(6)A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR.
Sun X, Tan Q, Yang Y, Wei J, Zhou X, Gao S, Yang F
Cell death & disease 2025 Jul 3;16(1):489
Cell death & disease 2025 Jul 3;16(1):489
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization.
Song H, Li ZW, Xu W, Tan Y, Kuang M, Pei G, Wang ZQ
Current issues in molecular biology 2025 Jul 29;47(8)
Current issues in molecular biology 2025 Jul 29;47(8)
AlkB Homolog 5 Regulates Hexokinase 2-Mediated Glycolysis and Participates in the Progression of Endometriosis.
Liu JJ, Fang YQ, Xiong WQ, Liu HW, Li JY, Wang XP, Wang HJ, Zhang L, Liu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70813
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70813
Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer.
Ji Y, Li R, Tang G, Xiao Y, Ye R, Shi J, Geng C, Ran R, Zhu C, Wang W, Chen C, Yang Q
Cellular and molecular life sciences : CMLS 2025 Jul 14;82(1):275
Cellular and molecular life sciences : CMLS 2025 Jul 14;82(1):275
Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F.
Tian Z, Zheng H, Fan Y, Li B, Huang Z, Wang M, Zhang J, Zhao J, Wang S, Xie J
Cells 2025 Jul 1;14(13)
Cells 2025 Jul 1;14(13)
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Zhai X, Yang R, Chu Q, Guo Z, Hou P, Li X, Bai C, Lu Z, Qiao L, Fu Y, Niu J, Li B
Nature cell biology 2025 Jan;27(1):141-153
Nature cell biology 2025 Jan;27(1):141-153
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
Li J, Bai R, Zhou Y, Song X, Li L
PLoS genetics 2025 Jan;21(1):e1011580
PLoS genetics 2025 Jan;21(1):e1011580
Targeting SphK1/S1PR3 axis ameliorates sepsis-induced multiple organ injury via orchestration of macrophage polarization and glycolysis.
Wang D, Bi X, Zhao L, Xiang S, Xi W, Yang S, Wu W, Chen T, Zheng L, Chi X, Kang Y
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119877
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119877
TIFA enhances glycolysis through E2F1 and promotes the progression of glioma.
Liu Z, He M, Yu Z, Ma L, Wang X, Ning F
Cellular signalling 2025 Jan;125:111498
Cellular signalling 2025 Jan;125:111498
Fatty acids promote migration of CD4(+) T cells through calcium release-activated calcium modulator ORAI1 sensitive glycolysis in dairy cows.
Zhang B, Wen J, Li M, Wang J, Ji Z, Lv X, Usman M, Mauck J, Loor JJ, Yang W, Wang G, Ma J, Xu C
Journal of dairy science 2025 Jan;108(1):856-867
Journal of dairy science 2025 Jan;108(1):856-867
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.
Bin Y, Liu M, He R, Tang P, Qu W, Wu D, Tan L, Wang Q, Jiang P, Hu H
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244
IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1.
Wei X, Su Y, Tian W, Cheng L, Yin L, He X
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16242
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16242
Functionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling.
Ge S, Sun A, Zhou X, Niu P, Chen Y, Bao X, Yu M, Zhong Z, Sun J, Li G
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(5):e2413371
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(5):e2413371
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H
Cancer gene therapy 2025 Feb;32(2):240-253
Cancer gene therapy 2025 Feb;32(2):240-253
Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium-Doped Nanosystem to Enhance Chemotherapy and Immunotherapy.
Cheng Q, Chen Y, Zou D, Li Q, Shi X, Qin Q, Liu M, Wang L, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409329
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409329
Fatty Acid Oxidation-Glycolysis Metabolic Transition Affects ECM Homeostasis in Silica-Induced Pulmonary Fibrosis.
Sun W, Zhou S, Peng L, Wang W, Liu Y, Wang T, Cheng D, Li Z, Xiong H, Jia X, Lian W, Jiao J, Ni C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2407134
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2407134
Micheliolide attenuates sepsis-induced acute lung injury by suppressing mitochondrial oxidative stress and PFKFB3-driven glycolysis.
Li W, Li Y, Xiao L, Xie Z, Peng J, Huang W, Li X, Meng Y
Journal of translational medicine 2025 Feb 14;23(1):181
Journal of translational medicine 2025 Feb 14;23(1):181
LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study.
Wang J, Li C, Wu G, Xu J
Annals of medicine 2025 Dec;57(1):2564284
Annals of medicine 2025 Dec;57(1):2564284
Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis.
Tan SM, Luo L, He YF, Li W, Wan XX
Cancer biology & therapy 2025 Dec;26(1):2442556
Cancer biology & therapy 2025 Dec;26(1):2442556
Juglone targets MMP-1 to inhibit gastric cancer progression.
Zhou F, Xie Y, Li X, Peng P
Biochemical pharmacology 2025 Dec;242(Pt 2):117289
Biochemical pharmacology 2025 Dec;242(Pt 2):117289
Exosomal miR-3126-5p derived from cancer-associated fibroblasts facilitates glycolysis to accelerate NSCLC progression by targeting KLF13 to activate the SH2B1/IRS1 axis.
Zhang Z, Ma H, Zheng Y, Wang L, Wang C, Liu Y, Lu H, Wang S
Clinical and translational medicine 2025 Dec;15(12):e70554
Clinical and translational medicine 2025 Dec;15(12):e70554
Reactivating T cell immunity in Wnt-hyperactivated non-small cell lung cancer through a supramolecular droplet of carnosic acid and peptide.
Liu N, Tu Y, Wang H, Zheng X, Ji F, Geng M, Wei X, Xin J, He W, Zhao Q, Liu T
Journal of pharmaceutical analysis 2025 Dec;15(12):101309
Journal of pharmaceutical analysis 2025 Dec;15(12):101309
SMARCA5 Cooperates With RSF1 to Promote Pathological Glycolysis and Chondrocyte Dysfunction in Osteoarthritis Through ATPase-Dependent Chromatin Regulation.
Xu J, Tang C, Shen H, Ni B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71324
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71324
Integrative multi-omics analysis proposes a metabolic classification of gliomas: distinct metabolic states, immune infiltration, and prognosis.
Zhu Q, Niu W, Mu M, Ye C, Niu C
Journal of translational medicine 2025 Dec 30;24(1):122
Journal of translational medicine 2025 Dec 30;24(1):122
[Morinda officinalis polysaccharide delays osteoarthritis mouse chondrocyte degeneration by modulating the glycolysis-pyroptosis axis via targeting the lncRNA XIST].
Fu C, Chen R, Xu S, You J, Lin Q, Huang Y
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2541-2550
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2541-2550
The SARS-CoV-2 nucleocapsid protein induces microglia senescence-mediated cognitive impairment via Glycolysis.
Yang NS, Sha HX, Zhang CY, Chen H, Liu YB, Xiong JB, Duan JX, Zhang J, Guan CX, Zhou Y, Su F, Zhong WJ
Molecular medicine (Cambridge, Mass.) 2025 Dec 12;32(1):7
Molecular medicine (Cambridge, Mass.) 2025 Dec 12;32(1):7
m6A-mediated regulation of ECA39 promotes renal fibrosis in chronic kidney disease by enhancing glycolysis and epithelial-mesenchymal transition.
Tong Z, Zhao H, Cui C, Hong M, Ma Y, Sui L, Wang J, Yuan Q, Sun L
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119981
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119981
Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation.
Zhang S, Wang YS, Li Y, To KI, Zhang ET, Jin YH
Cellular signalling 2025 Aug;132:111781
Cellular signalling 2025 Aug;132:111781
Activation of M1 macrophages promotes diabetic kidney disease by modulating glycolysis via HIF-1α-HK2 signaling pathway.
Pei X, Lu L, Huang Z, Wei Y, Li Y, Wang Q, Yang Y, Zhuang L, Jin G
Diabetology & metabolic syndrome 2025 Aug 29;17(1):362
Diabetology & metabolic syndrome 2025 Aug 29;17(1):362
Targeting TSPAN1 promotes ferroptosis in endometrial cancer cells, reduces energy metabolism and inhibits malignant behavior.
Fan Y, Xiao H, Wu Y, Yan R, Li P, Ma H
Gene 2025 Aug 20;962:149553
Gene 2025 Aug 20;962:149553
miRNA-204-5p acts as a tumor suppressor in gastric cancer by inhibiting cell migration, invasion, and glycolysis via the RAB22A/PI3K/AKT axis.
Pan W, Tan Y, Chen X, Zeng L, Lv Y, Yang J
Scientific reports 2025 Aug 12;15(1):29536
Scientific reports 2025 Aug 12;15(1):29536
O-GlcNAcylation of hexokinase 2 modulates mitochondrial dynamics and enhances the progression of lung cancer.
Panpan SI, Wei GE, Kaiming WU, Zhang R
Molecular and cellular biochemistry 2025 Apr;480(4):2633-2643
Molecular and cellular biochemistry 2025 Apr;480(4):2633-2643
Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy.
Wei Y, Sun MM, Zhang RL, Wang L, Yang LH, Shan CL, Lin JP
Acta pharmacologica Sinica 2025 Apr;46(4):1030-1044
Acta pharmacologica Sinica 2025 Apr;46(4):1030-1044
Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor.
Zhang Z, Wang R, Cai J, Li X, Feng X, Xu S, Jiang Z, Lin P, Huang Z, Xie Y
Toxicon : official journal of the International Society on Toxinology 2025 Apr;258:108339
Toxicon : official journal of the International Society on Toxinology 2025 Apr;258:108339
Polygala fallax Hemsl. ameliorated high glucose-induced podocyte injury by modulating mitochondrial mPTP opening through the SIRT1/PGC-1α pathway.
Shih-Wei C, Chen B, Mao Y, Xu Q, Chen Y
Archives of physiology and biochemistry 2025 Apr;131(2):135-146
Archives of physiology and biochemistry 2025 Apr;131(2):135-146
Activation of GPR35 by kynurenic acid inhibits IL-1β secretion in macrophages during CR-hvKP-induced pneumonia.
Zhang Q, Meng B, Tang M, Li C, Xu Y, Pan J, Yu L, Li Y, Yang Y, Liu Y, Li H, Hu L, Wu T, Li J
International immunopharmacology 2025 Apr 24;153:114416
International immunopharmacology 2025 Apr 24;153:114416
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.
Li WJ, Chen YC, Lin YA, Zou YQ, Hu GS, Yang JJ, Nie XY, Li MY, Wang YR, He YH, Zhao Y, Tan YH, Deng X, He WL, Cheng Y, Fu FM, Liu W
Cell reports 2025 Apr 22;44(4):115487
Cell reports 2025 Apr 22;44(4):115487
The interaction between IL-33 and TRIM28 in the regulation of macrophage polarization in an ST2-independent manner.
Zhao Y, Xu H, Liu Q, Yuan Y, Li R, Li D, Zhang Y, Ran J, Yan X, Su J
International immunopharmacology 2025 Apr 16;152:114318
International immunopharmacology 2025 Apr 16;152:114318
A coregulatory influence map of glioblastoma heterogeneity and plasticity.
Bernhard C, Geles K, Pawlak G, Dhifli W, Dispot A, Dusol J, Kondratova M, Martin S, Messé M, Reita D, Tulasne D, Van Seuningen I, Entz-Werle N, Ciafrè SA, Dontenwill M, Elati M
NPJ precision oncology 2025 Apr 15;9(1):110
NPJ precision oncology 2025 Apr 15;9(1):110
Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication.
Chen W, Wang X, Li X, Wang W, Huang Y, Qin Y, Liu P, Wu K, Li B, He Y, Zeng S, Yi L, Wang L, Zhao M, Ding H, Fan S, Li Z, Chen J
Veterinary research 2025 Apr 1;56(1):71
Veterinary research 2025 Apr 1;56(1):71
The m6A modification-mediated positive feedback between glycolytic lncRNA SLC2A1-DT and c-Myc promotes tumorigenesis of hepatocellular carcinoma.
Zeng Z, Wang J, Xu F, Hu P, Hu Y, Zhuo W, Chen D, Han S, Wang F, Zhao Y, Huang Y, Zhao G
International journal of biological sciences 2024;20(5):1744-1762
International journal of biological sciences 2024;20(5):1744-1762
Angiotensin-(1-7) Modulates the Warburg Effect to Alleviate Inflammation in LPS-Induced Macrophages and Septic Mice.
Yu D, Huang W, Sheng M, Zhang S, Pan H, Ren F, Luo L, Zhou J, Huang D, Tang L
Journal of inflammation research 2024;17:469-485
Journal of inflammation research 2024;17:469-485
PFKFB3 deprivation attenuates the cisplatin resistance via blocking its autophagic elimination in colorectal cancer cells.
Li Q, Ma J, Zhang Y, Sun F, Li W, Shen W, Ai Z, Li C, Wang S, Wei X, Yan S
Frontiers in pharmacology 2024;15:1433137
Frontiers in pharmacology 2024;15:1433137
The long noncoding RNA MIR4435-2HG enhances the migration, promotion, and glycolysis of nonsmall cell lung cancer cells by targeting the miR-371a-5p/SOX2/PI3K/Akt axis.
Yang J, Su Y, Wang Y, Gao K, Li C, Li M
SAGE open medicine 2024;12:20503121241289290
SAGE open medicine 2024;12:20503121241289290
Circ_0004674 regulation of glycolysis and proliferation mechanism of osteosarcoma through miR-140-3p/TCF4 pathway.
Ma Y, Du S, Wang S, Liu X, Cong L, Shen W, Ye K
Journal of biochemical and molecular toxicology 2024 Sep;38(9):e23846
Journal of biochemical and molecular toxicology 2024 Sep;38(9):e23846
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.
Li X, Wang G, Li N, Wang X, Fan W, Zhang Z, Li W, Liu J, Huang J, Liu X, Zhou Q, Hou S
Immunology 2024 Sep;173(1):141-151
Immunology 2024 Sep;173(1):141-151
PGD: Shared gene linking polycystic ovary syndrome and endometrial cancer, influencing proliferation and migration through glycometabolism.
Chen JM, Chen WH, Wang ZY, Zhou LY, Lin QY, Huang QY, Zheng LT, You HJ, Lin S, Shi QY
Cancer science 2024 Sep;115(9):2908-2922
Cancer science 2024 Sep;115(9):2908-2922
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y, Li T, Jiang Y
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis.
Zhao Q, Li X, Wu J, Zhang R, Chen S, Cai D, Xu H, Peng W, Li G, Nan A
Cell biology and toxicology 2024 Sep 18;40(1):78
Cell biology and toxicology 2024 Sep 18;40(1):78
Exogenous thyroxine increases cardiac GLUT4 translocation in insulin resistant OLETF rats.
Mendez DA, Soñanez-Organis JG, Yang X, Vazquez-Anaya G, Nishiyama A, Ortiz RM
Molecular and cellular endocrinology 2024 Sep 1;590:112254
Molecular and cellular endocrinology 2024 Sep 1;590:112254
Endoplasmic reticulum stress is attenuated by glycolysis in lymphatic malformations.
Li X, Zhong W, Jiang H, Wang P, Chai M, Zhu T, Liu J, Huang C, Yang S, Mou D, Zhou X, Cai Y
Pediatric research 2024 Oct;96(5):1210-1219
Pediatric research 2024 Oct;96(5):1210-1219
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis.
Zhang Y, Shen W, Chen Z, He J, Feng L, Wang L, Chen S
Journal of gastroenterology 2024 Oct;59(10):905-920
Journal of gastroenterology 2024 Oct;59(10):905-920
Dapagliflozin attenuates AKI to CKD transition in diabetes by activating SIRT3/PGC1-α signaling and alleviating aberrant metabolic reprogramming.
Li H, Xia Y, Zha H, Zhang Y, Shi L, Wang J, Huang H, Yue R, Hu B, Zhu J, Song Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167433
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167433
Histones Methyltransferase NSD3 Inhibits Lung Adenocarcinoma Glycolysis Through Interacting with PPP1CB to Decrease STAT3 Signaling Pathway.
Zhou Y, Peng X, Fang C, Peng X, Tang J, Wang Z, Long Y, Chen J, Peng Y, Zhang Z, Zhou Y, Tang J, Liao J, Xiao D, Tao Y, Shi Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2400381
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2400381
Tetradecyl 2,3-Dihydroxybenzoate Improves Cognitive Function in AD Mice by Modulating Autophagy and Inflammation Through IPA and Hsc70 Targeting.
Fasina OB, Li L, Chen D, Yi M, Xiang L, Qi J
International journal of molecular sciences 2024 Oct 31;25(21)
International journal of molecular sciences 2024 Oct 31;25(21)
Sini decoction-polysaccharide compound regulates proliferation, apoptosis, and glycolysis of liver cancer cells through PHLDA2/ANXA2.
Shen C, Huang P, Xie W, Ni X, Gao J
Translational cancer research 2024 Oct 31;13(10):5574-5587
Translational cancer research 2024 Oct 31;13(10):5574-5587
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Yan P, Yang K, Xu M, Zhu M, Duan Y, Li W, Liu L, Liang C, Li Z, Pan X, Wang L, Yu G
Journal of molecular cell biology 2024 Oct 21;16(5)
Journal of molecular cell biology 2024 Oct 21;16(5)
Quercetin alleviates liver fibrosis via regulating glycolysis of liver sinusoidal endothelial cells and neutrophil infiltration.
Chen X, Wang Y, Wan J, Dou X, Zhang C, Sun M, Ye F
Biomolecules & biomedicine 2024 Oct 17;24(6):1806-1815
Biomolecules & biomedicine 2024 Oct 17;24(6):1806-1815
TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth.
Xia T, Meng L, Xu G, Sun H, Chen H
Cell death & disease 2024 Oct 10;15(10):740
Cell death & disease 2024 Oct 10;15(10):740
STC2 knockdown inhibits cell proliferation and glycolysis in hepatocellular carcinoma through promoting autophagy by PI3K/Akt/mTOR pathway.
Li D, Xiong Y, Li M, Long L, Zhang Y, Yan H, Xiang H
Archives of biochemistry and biophysics 2024 Nov;761:110149
Archives of biochemistry and biophysics 2024 Nov;761:110149
Downregulation of C1R promotes hepatocellular carcinoma development by activating HIF-1α-regulated glycolysis.
Ma Y, Wang Y, Tuo P, Meng Z, Jiang B, Yuan Y, Ding Y, Naeem A, Guo X, Wang X
Molecular carcinogenesis 2024 Nov;63(11):2237-2253
Molecular carcinogenesis 2024 Nov;63(11):2237-2253
LncRNA MBNL1-AS1 knockdown increases the sensitivity of hepatocellular carcinoma to tripterine by regulating miR-708-5p-mediated glycolysis.
Zhang H, Zhao L, Ren P, Sun X
Biotechnology & genetic engineering reviews 2024 Nov;40(3):1407-1424
Biotechnology & genetic engineering reviews 2024 Nov;40(3):1407-1424
Dietary pectin and inulin: A promising adjuvant supplement for collagen-induced arthritis through gut microbiome restoration and CD4(+) T cell reconstitution.
Lou Y, Wen X, Song S, Zeng Y, Huang L, Xie Z, Shao T, Wen C
The Journal of nutritional biochemistry 2024 Nov;133:109699
The Journal of nutritional biochemistry 2024 Nov;133:109699
Influenza A virus-induced glycolysis facilitates virus replication by activating ROS/HIF-1α pathway.
Zhang Y, Chang L, Xin X, Qiao Y, Qiao W, Ping J, Xia J, Su J
Free radical biology & medicine 2024 Nov 20;225:910-924
Free radical biology & medicine 2024 Nov 20;225:910-924
Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats.
Li MC, Jia JT, Wang YX, Zhuang YM, Wang HY, Lin ZY, Lu Y, Li MZ, Wang ZJ, Zhao H
Journal of ethnopharmacology 2024 Nov 15;334:118532
Journal of ethnopharmacology 2024 Nov 15;334:118532
Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment.
Chen Y, Chen Y, Wang Z, Yang L, Zhang Y, Zhang Z, Jia L
Journal of nanobiotechnology 2024 Nov 14;22(1):705
Journal of nanobiotechnology 2024 Nov 14;22(1):705
Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1.
Zhu G, Guan F, Li S, Zhang Q, Zhang X, Qin Y, Sun Z, Peng S, Cheng J, Li Y, Ren R, Fan T, Liu H
Molecular carcinogenesis 2024 May;63(5):897-911
Molecular carcinogenesis 2024 May;63(5):897-911
Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.
Xu M, Zhong W, Yang C, Liu M, Yuan X, Lu T, Li D, Zhang G, Liu H, Zeng Y, Yang X, Zhou Y, Zhou L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155392
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155392
Mechanism study of lncRNA RMRP regulating esophageal squamous cell carcinoma through miR-580-3p/ATP13A3 axis.
Tan Z, Luan S, Wang X, Jiao W, Jiang P
Discover oncology 2024 May 9;15(1):150
Discover oncology 2024 May 9;15(1):150
Flavokawain C inhibits glucose metabolism and tumor angiogenesis in nasopharyngeal carcinoma by targeting the HSP90B1/STAT3/HK2 signaling axis.
Hu Y, Yu C, Cheng L, Zhong C, An J, Zou M, Liu B, Gao X
Cancer cell international 2024 May 6;24(1):158
Cancer cell international 2024 May 6;24(1):158
PRR34-AS1 promotes mitochondrial division and glycolytic reprogramming in hepatocellular carcinoma cells through upregulation of MIEF2.
Yang X, Feng H, Kim J, Ti G, Wang L, Wang K, Song D
Acta biochimica et biophysica Sinica 2024 May 22;56(11):1604-1617
Acta biochimica et biophysica Sinica 2024 May 22;56(11):1604-1617
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.
Luo J, Yang Y, Zhang G, Fang D, Liu K, Mei Y, Wang F
Cell death & disease 2024 May 21;15(5):354
Cell death & disease 2024 May 21;15(5):354
Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation.
Xu X, Xie T, Zhou M, Sun Y, Wang F, Tian Y, Chen Z, Xie Y, Wu R, Cen X, Zhou J, Hou T, Zhang L, Huang C, Zhao Q, Wang D, Xia H
Nature communications 2024 May 18;15(1):4237
Nature communications 2024 May 18;15(1):4237
Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis.
Tao Y, Gong Z, Shen S, Ding Y, Zan R, Zheng B, Sun W, Ma C, Shu M, Lu X, Liu H, Ni X, Liu H, Suo T
iScience 2024 May 17;27(5):109659
iScience 2024 May 17;27(5):109659
Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency.
Zhen X, Betti MJ, Kars ME, Patterson A, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick OM, Gamazon E, Rathmell JC, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R
medRxiv : the preprint server for health sciences 2024 May 14;
medRxiv : the preprint server for health sciences 2024 May 14;
Mucous cell histopathology and label-free quantitative proteomic analysis of skin mucus in fat greenling (Hexagrammos otakii) infected with Vibrio harveyi.
Wei X, Shi Y, Wang S, Liu H, Zhang Z, Yu L, Hua W, Cui D, Chen Y, Li X, Wang W
Fish & shellfish immunology 2024 Mar;146:109398
Fish & shellfish immunology 2024 Mar;146:109398
p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration.
Yang Y, Song B, Guo M, Gao J, Jiang L, Li Q, Liu Y, Cao J
Ecotoxicology and environmental safety 2024 Mar 1;272:116076
Ecotoxicology and environmental safety 2024 Mar 1;272:116076
METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer.
Yuan XN, Shao YC, Guan XQ, Liu Q, Chu MF, Yang ZL, Li H, Zhao S, Tian YH, Zhang JW, Wei L
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119716
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119716
Hypoxia-mediated attenuation of EGLN2 inhibition of the NF-κB signaling pathway leads to the formation of a loop between HIF-1α and MUC1-C promoting chemoresistance in bladder cancer.
Qing L, Li Q, Yang Y, Xu W, Wang Y, Li R, You C, Dong Z
Molecular carcinogenesis 2024 Jul;63(7):1303-1318
Molecular carcinogenesis 2024 Jul;63(7):1303-1318
DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway.
Di SC, Chen WJ, Yang W, Zhang XM, Dong KQ, Tian YJ, Sun Y, Qian C, Chen JX, Liu ZC, Gong ZX, Chu J, Zhou W, Pan XW, Cui XG
Cell death & disease 2024 Jul 27;15(7):533
Cell death & disease 2024 Jul 27;15(7):533
β-catenin mediates monocrotaline-induced pulmonary hypertension via glycolysis in rats.
Meng H, Deng Y, Liao J, Wu DD, Li LX, Chen X, Lan WF
BMC cardiovascular disorders 2024 Jul 23;24(1):381
BMC cardiovascular disorders 2024 Jul 23;24(1):381
Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats.
Yan Q, Liu H, Sun S, Yang Y, Fan D, Yang Y, Zhao Y, Song Z, Chen Y, Zhu R, Zhang Z
Journal of nanobiotechnology 2024 Jul 18;22(1):423
Journal of nanobiotechnology 2024 Jul 18;22(1):423
Sanguinarine Induces Necroptosis of HCC by Targeting PKM2 Mediated Energy Metabolism.
Kong R, Wang N, Zhou C, Zhou Y, Guo X, Wang D, Shi Y, Wan R, Zheng Y, Lu J
Cancers 2024 Jul 13;16(14)
Cancers 2024 Jul 13;16(14)
The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis.
Zhao L, Yu N, Zhai Y, Yang Y, Wang Y, Yang Y, Gong Z, Zhang Y, Zhang X, Guo W
Cell death & disease 2024 Jul 13;15(7):502
Cell death & disease 2024 Jul 13;15(7):502
Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency.
Zhen X, Betti M, Kars ME, Patterson A, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick O, Gamazon E, Rathmell J, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R
Research square 2024 Jul 11;
Research square 2024 Jul 11;
Identification of hub glycolysis-related genes in acute myocardial infarction and their correlation with immune infiltration using bioinformatics analysis.
Zhang X, Zhang L, Gao Y, Liu Z, Gong K
BMC cardiovascular disorders 2024 Jul 10;24(1):349
BMC cardiovascular disorders 2024 Jul 10;24(1):349
OCT1 regulates the migration of colorectal cancer cells by acting on LDHA.
Li L, Chen W, Wu G, Sun P
Histology and histopathology 2024 Jan;39(1):67-77
Histology and histopathology 2024 Jan;39(1):67-77
Carrier-free nanodrug targeting glucose metabolism for enhanced rheumatoid arthritis treatment.
Chen T, Lin X, Li D, Pan L, Qin X, Ye W, Luo Z, Wang Q
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113668
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113668
Cryptotanshinone suppresses ovarian cancer via simultaneous inhibition of glycolysis and oxidative phosphorylation.
Wang T, Zhang M, Khan M, Li J, Wu X, Ma T, Li Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115956
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115956
Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism.
Maio G, Smith M, Bhawal R, Zhang S, Baskin JM, Li J, Lin H
Molecular & cellular proteomics : MCP 2024 Feb;23(2):100709
Molecular & cellular proteomics : MCP 2024 Feb;23(2):100709
Fluvoxamine inhibits Th1 and Th17 polarization and function by repressing glycolysis to attenuate autoimmune progression in type 1 diabetes.
Zou Y, Zhang J, Sun F, Xu Q, Chen L, Luo X, Wang T, Zhou Q, Zhang S, Xiong F, Kong W, Yang P, Yu Q, Liu S, Wang CY
Molecular medicine (Cambridge, Mass.) 2024 Feb 5;30(1):23
Molecular medicine (Cambridge, Mass.) 2024 Feb 5;30(1):23
AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.
Sun Y, Zhang S, Zhang X, Li G, Sun F, Wang M, Ren C, Jiang A, Yang T
Endocrinology 2024 Feb 20;165(4)
Endocrinology 2024 Feb 20;165(4)
E. Coli LPS-induced calcium signaling regulates the expression of hypoxia-inducible factor 1α in periodontal ligament fibroblasts in a non-hypoxia-dependent manner.
Yang X, Cai X, Lin J, Zheng Y, Liao Z, Lin W, He X, Zhang Y, Ren X, Liu C
International immunopharmacology 2024 Feb 15;128:111418
International immunopharmacology 2024 Feb 15;128:111418
Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis.
Zhang T, Hasegawa Y, Waldor MK
Nature microbiology 2024 Dec;9(12):3376-3390
Nature microbiology 2024 Dec;9(12):3376-3390
Cepharanthine inhibits African swine fever virus replication by suppressing AKT-associated pathways through disrupting Hsp90-Cdc37 complex.
Su G, Su L, Luo D, Yang X, Liu Z, Lin Q, An T, Weng C, Chen W, Zeng Z, Chen J
International journal of biological macromolecules 2024 Dec;282(Pt 4):137070
International journal of biological macromolecules 2024 Dec;282(Pt 4):137070
YAP1 Overexpression Enhances the Aerobic Glycolysis Process via Suppression of EGLN2 in Pancreatic Ductal Adenocarcinoma.
Hu P, Dou R, Qi Z, Liu G, Su Y
The journal of gene medicine 2024 Dec;26(12):e70006
The journal of gene medicine 2024 Dec;26(12):e70006
Activation of ferritin light chain (FTL) by transcription factor salmonella pathogenicity island 1 modulates glycolysis to drive metastasis of ovarian cancer cells.
Li C, Yang Y, Lin Y, Lian Y, Pan D, Lin L, Li L
Expert review of anticancer therapy 2024 Dec;24(12):1271-1282
Expert review of anticancer therapy 2024 Dec;24(12):1271-1282
Dynamic changes of protein lactylation and their correlations with the glycolytic process during the postmortem acidification of broiler breast.
Wang Z, Xing T, Zhang L, Zhao L, Gao F
Poultry science 2024 Dec;103(12):104354
Poultry science 2024 Dec;103(12):104354
Molecular and Clinical Characterization of a Founder Mutation Causing G6PC3 Deficiency.
Zhen X, Betti MJ, Kars ME, Patterson AR, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick OM, Gamazon ER, Rathmell JC, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R
Journal of clinical immunology 2024 Dec 4;45(1):53
Journal of clinical immunology 2024 Dec 4;45(1):53
Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia.
Sun T, Yu H, Zhang D, Li D, Fu J
Respiratory research 2024 Dec 26;25(1):443
Respiratory research 2024 Dec 26;25(1):443
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1.
Lin Y, Li L, Yuan B, Luo F, Zhang X, Yang Y, Luo S, Lin J, Ye T, Zhang Y, Gao S, Ye Q
Signal transduction and targeted therapy 2024 Dec 2;9(1):337
Signal transduction and targeted therapy 2024 Dec 2;9(1):337
Antitumorigenic potential of Lactobacillus-derived extracellular vesicles: p53 succinylation and glycolytic reprogramming in intestinal epithelial cells via SIRT5 modulation.
Zhang J, Huang X, Zhang T, Gu C, Zuo W, Fu L, Dong Y, Liu H
Cell biology and toxicology 2024 Aug 7;40(1):66
Cell biology and toxicology 2024 Aug 7;40(1):66
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
Zheng JH, Zhu YH, Yang J, Ji PX, Zhao RK, Duan ZH, Yao HF, Jia QY, Yin YF, Hu LP, Li Q, Jiang SH, Huo YM, Liu W, Sun YW, Liu DJ
Cell reports 2024 Aug 27;43(8):114633
Cell reports 2024 Aug 27;43(8):114633
N(6)-methyladenosine-modified SRPK1 promotes aerobic glycolysis of lung adenocarcinoma via PKM splicing.
Wang A, Zeng Y, Zhang W, Zhao J, Gao L, Li J, Zhu J, Liu Z, Huang JA
Cellular & molecular biology letters 2024 Aug 2;29(1):106
Cellular & molecular biology letters 2024 Aug 2;29(1):106
CircNAP1L4 regulates pulmonary artery smooth muscle cell proliferation via the NAP1L4-mediated super-enhancer-driven glycolysis gene hexokinase II (HK II) in pulmonary hypertension.
Wang X, Guan X, Zhu X, Zhang L, Ma C, He S, Bai J, Mei J, Li Q, Sun N, Wu B, Zhu D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23868
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23868
Mitochondria-Targeted Multifunctional Nanoprodrugs by Inhibiting Metabolic Reprogramming for Combating Cisplatin-Resistant Lung Cancer.
Lu H, Tong W, Jiang M, Liu H, Meng C, Wang K, Mu X
ACS nano 2024 Aug 13;18(32):21156-21170
ACS nano 2024 Aug 13;18(32):21156-21170
The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.
Yin H, Liu Y, Dong Q, Wang H, Yan Y, Wang X, Wan X, Yuan G, Pan Y
Cancer letters 2024 Aug 10;597:216862
Cancer letters 2024 Aug 10;597:216862
Age-Related Gut Microbiota Transplantation Disrupts Myocardial Energy Homeostasis and Induces Oxidative Damage.
Xu H, Li O, Kim D, Yang F, Bao Z
The Journal of nutrition 2024 Apr;154(4):1189-1199
The Journal of nutrition 2024 Apr;154(4):1189-1199
Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.
Liu B, Xian Y, Chen X, Shi Y, Dong J, Yang L, An X, Shen T, Wu W, Ma Y, He Y, Gong W, Peng R, Lin J, Liu N, Guo B, Jiang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307338
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307338
Circular RNA COL1A1 promotes Warburg effect and tumor growth in nasopharyngeal carcinoma.
Zhou Z, Xu F, Zhang T
Discover oncology 2024 Apr 15;15(1):120
Discover oncology 2024 Apr 15;15(1):120
Metabolic reprogramming of cancer-associated fibroblasts in pancreatic cancer contributes to the intratumor heterogeneity of PET-CT.
Meng Q, Fang Z, Mao X, Tang R, Liang C, Hua J, Wang W, Shi S, Yu X, Xu J
Computational and structural biotechnology journal 2023;21:2631-2639
Computational and structural biotechnology journal 2023;21:2631-2639
Porcine reproductive and respiratory syndrome virus-mediated lactate facilitates virus replication by targeting MAVS.
Zhang L, Liu X, Mao J, Sun Y, Gao Y, Bai J, Jiang P
Veterinary microbiology 2023 Sep;284:109846
Veterinary microbiology 2023 Sep;284:109846
METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury.
Zhang H, Wu D, Wang Y, Guo K, Spencer CB, Ortoga L, Qu M, Shi Y, Shao Y, Wang Z, Cata JP, Miao C
Clinical and translational medicine 2023 Sep;13(9):e1389
Clinical and translational medicine 2023 Sep;13(9):e1389
HOXA1 promotes aerobic glycolysis and cancer progression in cervical cancer.
Zhang Z, Peng J, Li B, Wang Z, Wang H, Wang Y, Hong L
Cellular signalling 2023 Sep;109:110747
Cellular signalling 2023 Sep;109:110747
Osteogenic microenvironment affects palatal development through glycolysis.
Peng X, Chen J, Wang Y, Wang X, Zhao X, Zheng X, Wang Z, Yuan D, Du J
Differentiation; research in biological diversity 2023 Sep-Oct;133:1-11
Differentiation; research in biological diversity 2023 Sep-Oct;133:1-11
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement.
Zhang C, Wang H, Liu Q, Dai S, Tian G, Wei X, Li X, Zhao L, Shan B
Journal of experimental & clinical cancer research : CR 2023 Sep 23;42(1):246
Journal of experimental & clinical cancer research : CR 2023 Sep 23;42(1):246
hsa_circ_0003596, as a novel oncogene, regulates the malignant behavior of renal cell carcinoma by modulating glycolysis.
Xie Q, Qin F, Luo L, Deng S, Zeng K, Wu Y, Liao D, Luo L, Wang K
European journal of medical research 2023 Sep 2;28(1):315
European journal of medical research 2023 Sep 2;28(1):315
Single-cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell-type-specific mechanisms.
Yao Y, Chen Z, Wu Q, Lu Y, Zhou X, Zhu X
MedComm 2023 Oct;4(5):e372
MedComm 2023 Oct;4(5):e372
LINC02774 inhibits glycolysis in glioma to destabilize HIF-1α dependent on transcription factor RP58.
Chen Y, Liu Y, Xiong J, Ouyang L, Tang M, Mao C, Li L, Xiao D, Liu S, Yang Z, Huang J, Tao Y
MedComm 2023 Oct;4(5):e364
MedComm 2023 Oct;4(5):e364
IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.
Wu T, Liao L, Wu T, Chen S, Yi Q, Xu M
Cell cycle (Georgetown, Tex.) 2023 Oct;22(20):2245-2263
Cell cycle (Georgetown, Tex.) 2023 Oct;22(20):2245-2263
Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via a nuclear receptor (Nur77)-mediated epigenetic regulation of glutaminase 1.
Chen L, Liang B, Xia S, Wang F, Li Z, Shao J, Zhang Z, Chen A, Zheng S, Zhang F
British journal of pharmacology 2023 Oct;180(19):2577-2598
British journal of pharmacology 2023 Oct;180(19):2577-2598
LDHA and LDHB overexpression promoted the Warburg effect in malignantly transformed GES-1 cells induced by N-nitroso compounds.
Liu X, Zou X, Zhou Y, Chen R, Peng Y, Qu M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114007
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114007
Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia.
Hu P, Hu L, Chen Y, Wang F, Xiao Y, Tong Z, Li H, Xiang M, Tong Q, Zhang Y
Bioorganic chemistry 2023 Oct;139:106701
Bioorganic chemistry 2023 Oct;139:106701
Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes.
Zhao Q, Yu C, Xu X, Jin W, Zhang Z, Huang H, Gao Y, Pan D
iScience 2023 Oct 20;26(10):108091
iScience 2023 Oct 20;26(10):108091
Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis.
Zhao Z, Zhang H, Zhang F, Ji Y, Peng Y, Wang F, Zhao L
Acta biochimica Polonica 2023 Oct 18;70(4):855-863
Acta biochimica Polonica 2023 Oct 18;70(4):855-863
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J
Cell death and differentiation 2023 Nov;30(11):2393-2407
Cell death and differentiation 2023 Nov;30(11):2393-2407
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion.
Yan S, Ding J, Wang Z, Zhang F, Li J, Zhang Y, Wu S, Yang L, Pang X, Zhang Y, Yang J
International immunopharmacology 2023 Nov;124(Pt A):110840
International immunopharmacology 2023 Nov;124(Pt A):110840
The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells.
Galiger C, Zohora FT, Dorneburg C, Tews D, Debatin KM, Beltinger C
BMC cancer 2023 Nov 25;23(1):1148
BMC cancer 2023 Nov 25;23(1):1148
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.
Zhang L, Liang J, Qin H, Lv Y, Liu X, Li Z, Chao Z, Jia C, Qin X, Zhang H
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296
Butyrate prevents the migration and invasion, and aerobic glycolysis in gastric cancer via inhibiting Wnt/β-catenin/c-Myc signaling.
Liang Y, Rao Z, Du D, Wang Y, Fang T
Drug development research 2023 May;84(3):532-541
Drug development research 2023 May;84(3):532-541
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Yang J, Hasenbilige, Bao S, Luo S, Jiang L, Li Q, Kong Y, Cao J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Mar;173:113609
NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling.
Ma S, Chen Y, Quan P, Zhang J, Han S, Wang G, Qi R, Zhang X, Wang F, Yuan J, Yang X, Jia W, Qin W
BMC cancer 2023 Mar 28;23(1):280
BMC cancer 2023 Mar 28;23(1):280
Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice.
Han S, He Z, Hu X, Li X, Zheng K, Huang Y, Xiao P, Xie Q, Ni J, Liu Q
Antioxidants (Basel, Switzerland) 2023 Mar 15;12(3)
Antioxidants (Basel, Switzerland) 2023 Mar 15;12(3)
Rare sugar L-sorbose exerts antitumor activity by impairing glucose metabolism.
Xu HL, Zhou X, Chen S, Xu S, Li Z, Nakanishi H, Gao XD
Communications biology 2023 Mar 11;6(1):259
Communications biology 2023 Mar 11;6(1):259
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Ma Y, Zhang X, Han X, Hao Z, Ji R, Li J, Guo W, Zhang Y, Guan F, Ma S
Molecular carcinogenesis 2023 Jun;62(6):866-881
Molecular carcinogenesis 2023 Jun;62(6):866-881
Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC.
Fan L, Xia P, Wang J, Xu S, Qiu Z, Wu Y, Feng M, Zhao Q, Wang H, Li X
Molecular carcinogenesis 2023 Jun;62(6):820-832
Molecular carcinogenesis 2023 Jun;62(6):820-832
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.
He Y, Wang Y, Jia X, Li Y, Yang Y, Pan L, Zhao R, Han Y, Wang F, Guan X, Hou T
International immunopharmacology 2023 Jun;119:110192
International immunopharmacology 2023 Jun;119:110192
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Cai Z, Li Y, Ma M, Wang L, Wang H, Liu M, Jiang C
Oncology reports 2023 Jul;50(1)
Oncology reports 2023 Jul;50(1)
Disruption of COMMD1 accelerates diabetic atherosclerosis by promoting glycolysis.
Zhang L, Li L, Li Y, Jiang H, Sun Z, Zang G, Qian Y, Shao C, Wang Z
Diabetes & vascular disease research 2023 Jan-Feb;20(1):14791641231159009
Diabetes & vascular disease research 2023 Jan-Feb;20(1):14791641231159009
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4.
Luo S, Zhang C, Gao Z, Jiang L, Li Q, Shi X, Kong Y, Cao J
Chemico-biological interactions 2023 Jan 5;369:110293
Chemico-biological interactions 2023 Jan 5;369:110293
Exploratory metabolomic analysis based on UHPLC-Q-TOF-MS/MS to study hypoxia-reoxygenation energy metabolic alterations in HK-2 cells.
Yang X, Kang A, Lu Y, Li Y, Guo L, Li R, Zhou X
Renal failure 2023 Dec;45(1):2186715
Renal failure 2023 Dec;45(1):2186715
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells.
Yang K, Li X, Qiu T, Zhou J, Gong X, Lan Y, Ji Y
Biochemical pharmacology 2023 Dec;218:115922
Biochemical pharmacology 2023 Dec;218:115922
Effect of chronic heat stress on the carbonylation of glycolytic enzymes in breast muscle and its correlation with the growth performance of broilers.
Liu Y, Liu Z, Xing T, Li J, Zhang L, Zhao L, Gao F
Poultry science 2023 Dec;102(12):103103
Poultry science 2023 Dec;102(12):103103
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
Huang X, Gao L, Deng R, Peng Y, Wu S, Lu J, Liu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114989
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114989
Relationship between the expression of PD-L1 and (18)F-FDG uptake in pancreatic ductal adenocarcinoma.
Li J, Chen R, Chen Y, Xia Q, Zhou X, Xia Q, Wang C, Wan L, Bao H, Huang G, Liu J
British journal of cancer 2023 Aug;129(3):541-550
British journal of cancer 2023 Aug;129(3):541-550
Experimental Study of Warburg Effect in Keloid Nodules: Implication for Downregulation of miR-133b.
Lee Y, Ito Y, Taniguchi K, Nuri T, Lee S, Ueda K
Plastic and reconstructive surgery. Global open 2023 Aug;11(8):e5202
Plastic and reconstructive surgery. Global open 2023 Aug;11(8):e5202
Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis.
Rho H, Terry AR, Chronis C, Hay N
Cell metabolism 2023 Aug 8;35(8):1406-1423.e8
Cell metabolism 2023 Aug 8;35(8):1406-1423.e8
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.
Zheng Y, Zhan Y, Zhang Y, Zhang Y, Liu Y, Xie Y, Sun Y, Qian J, Ding Y, Ding Y, Fang Y
Cell death & disease 2023 Aug 1;14(8):488
Cell death & disease 2023 Aug 1;14(8):488
Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism.
Gui X, Zhang H, Zhang R, Li Q, Zhu W, Nie Z, Zhao J, Cui X, Hao W, Wen X, Shen W, Song H
Materials today. Bio 2023 Apr;19:100602
Materials today. Bio 2023 Apr;19:100602
ErbB2-upregulated HK1 and HK2 promote breast cancer cell proliferation, migration and invasion.
Ma X, Chen J, Huang B, Fu S, Qu S, Yu R, Zhao Y
Medical oncology (Northwood, London, England) 2023 Apr 20;40(5):154
Medical oncology (Northwood, London, England) 2023 Apr 20;40(5):154
Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer's Disease.
Ma X, Zhang Y, Gou D, Ma J, Du J, Wang C, Li S, Cui H
Journal of Alzheimer's disease : JAD 2022;88(2):771-785
Journal of Alzheimer's disease : JAD 2022;88(2):771-785
Cordycepin Inhibits the Growth of Hepatocellular Carcinoma by Regulating the Pathway of Aerobic Glycolysis.
Chen Y, Jiang Y, Huang X, Chen L, Yang H, Zhao J, Liang B
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6454482
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6454482
Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS.
Yuan Y, Wang W, Zhang Y, Hong Q, Huang W, Li L, Xie Z, Chen Y, Li X, Meng Y
Journal of inflammation research 2022;15:2121-2139
Journal of inflammation research 2022;15:2121-2139
Mechanism of selenomethionine inhibiting of PDCoV replication in LLC-PK1 cells based on STAT3/miR-125b-5p-1/HK2 signaling.
Ren Z, Ding T, He H, Wei Z, Shi R, Deng J
Frontiers in immunology 2022;13:952852
Frontiers in immunology 2022;13:952852
Effects of Glycolysis-Related Genes on Prognosis and the Tumor Microenvironment of Hepatocellular Carcinoma.
Zheng JY, Liu JY, Zhu T, Liu C, Gao Y, Dai WT, Zhuo W, Mao XY, He BM, Liu ZQ
Frontiers in pharmacology 2022;13:895608
Frontiers in pharmacology 2022;13:895608
Number 2 Feibi Recipe Inhibits H(2)O(2)-Mediated Oxidative Stress Damage of Alveolar Epithelial Cells by Regulating the Balance of Mitophagy/Apoptosis.
Gu X, Long Q, Wei W, Tong J, Li Z, Zhang Z, Jiao Y
Frontiers in pharmacology 2022;13:830554
Frontiers in pharmacology 2022;13:830554
Singapore Grouper Iridovirus Induces Glucose Metabolism in Infected Cells by Activation of Mammalian Target of Rapamycin Signaling.
Guo X, Zheng Q, Pan Z, Huang Y, Huang X, Qin Q
Frontiers in microbiology 2022;13:827818
Frontiers in microbiology 2022;13:827818
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth.
Yi X, Qi M, Huang M, Zhou S, Xiong J
Frontiers in pharmacology 2022;13:796763
Frontiers in pharmacology 2022;13:796763
AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.
Wu C, Dai C, Li X, Sun M, Chu H, Xuan Q, Yin Y, Fang C, Yang F, Jiang Z, Lv Q, He K, Qu Y, Zhao B, Cai K, Zhang S, Sun R, Xu G, Zhang L, Sun S, Liu Y
Theranostics 2022;12(18):7681-7698
Theranostics 2022;12(18):7681-7698
TRIM16 promotes aerobic glycolysis and pancreatic cancer metastasis by modulating the NIK-SIX1 axis in a ligase-independent manner.
Zhou B, Huang Y, Feng Q, Zhu H, Xu Z, Chen L, Peng X, Yang W, Xu D, Qiu Y
American journal of cancer research 2022;12(11):5205-5225
American journal of cancer research 2022;12(11):5205-5225
3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model.
Roy S, Dukic T, Bhandary B, Tu KJ, Molitoris J, Ko YH, Shukla HD
American journal of cancer research 2022;12(11):4977-4987
American journal of cancer research 2022;12(11):4977-4987
Changes in the Expression of MIF and Other Key Enzymes of Energy Metabolism in the Myocardia of Broiler Chickens with Ascites Syndrome.
Li L, Jia Q, Chen L, Wang W
Animals : an open access journal from MDPI 2022 Sep 20;12(19)
Animals : an open access journal from MDPI 2022 Sep 20;12(19)
Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1.
Zheng X, Pan Y, Yang G, Liu Y, Zou J, Zhao H, Yin G, Wu Y, Li X, Wei Z, Yu S, Zhao Y, Wang A, Chen W, Lu Y
European journal of pharmacology 2022 Sep 15;931:175226
European journal of pharmacology 2022 Sep 15;931:175226
A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.
Zhu Y, Sun Y, Rui B, Lin J, Shen J, Xiao H, Liu X, Chai Y, Xu J, Yang Y
ACS applied materials & interfaces 2022 Sep 14;14(36):40674-40687
ACS applied materials & interfaces 2022 Sep 14;14(36):40674-40687
Fibroblast growth factor 7 alleviates myocardial infarction by improving oxidative stress via PI3Kα/AKT-mediated regulation of Nrf2 and HXK2.
Mei L, Chen Y, Chen P, Chen H, He S, Jin C, Wang Y, Hu Z, Li W, Jin L, Cong W, Wang X, Guan X
Redox biology 2022 Oct;56:102468
Redox biology 2022 Oct;56:102468
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
Zhao X, Shu D, Sun W, Si S, Ran W, Guo B, Cui L
Cancer communications (London, England) 2022 Oct;42(10):987-1007
Cancer communications (London, England) 2022 Oct;42(10):987-1007
The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis.
Cui K, Wu H, Fan J, Zhang L, Li H, Guo H, Yang R, Li Z
International journal of molecular sciences 2022 Oct 11;23(20)
International journal of molecular sciences 2022 Oct 11;23(20)
HMGA2 mediates Cr (VI)-induced metabolic reprogramming through binding to mitochondrial D-Loop region.
Bao S, Zhang C, Luo S, Jiang L, Li Q, Kong Y, Cao J
Ecotoxicology and environmental safety 2022 Oct 1;244:114085
Ecotoxicology and environmental safety 2022 Oct 1;244:114085
Curcumin attenuates Cr (VI)-induced cell growth and migration by targeting autophagy-dependent reprogrammed metabolism.
Dlamini MB, Bao S, Gao Z, Mei J, Ge H, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Journal of biochemical and molecular toxicology 2022 Nov;36(11):e23193
Journal of biochemical and molecular toxicology 2022 Nov;36(11):e23193
N-phenethyl-5-phenylpicolinamide alleviates inflammation in acute lung injury by inhibiting HIF-1α/glycolysis/ASIC1a pathway.
Du N, Lin H, Zhang A, Cao C, Hu X, Zhang J, Wang L, Pan X, Zhu Y, Qian F, Wang Y, Zhao D, Liu M, Huang Y
Life sciences 2022 Nov 15;309:120987
Life sciences 2022 Nov 15;309:120987
Jumonji-C domain-containing protein 5 suppresses proliferation and aerobic glycolysis in pancreatic cancer cells in a c-Myc-dependent manner.
Wang H, Wang J, Liu J, Wang Y, Xia G, Huang X
Cellular signalling 2022 May;93:110282
Cellular signalling 2022 May;93:110282
VLCAD inhibits the proliferation and invasion of hepatocellular cancer cells through regulating PI3K/AKT axis.
Zhu QW, Yu Y, Zhang Y, Wang XH
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 May;24(5):864-874
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2022 May;24(5):864-874
Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/β-catenin signaling pathway.
Jin X, Shao X, Pang W, Wang Z, Huang J
Bioengineered 2022 May;13(5):13033-13044
Bioengineered 2022 May;13(5):13033-13044
Berberine Modulates Macrophage Activation by Inducing Glycolysis.
Li M, Zhang H, Zhang Y, Fan J, Zhu J, Gu X, Li Z, Zhang C, Liu Z, Li Y, Zang M, Jin G, Li G, Mi Y
Journal of immunology (Baltimore, Md. : 1950) 2022 May 15;208(10):2309-2318
Journal of immunology (Baltimore, Md. : 1950) 2022 May 15;208(10):2309-2318
A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells.
Sofer S, Lamkiewicz K, Armoza Eilat S, Partouche S, Marz M, Moskovits N, Stemmer SM, Shlomai A, Sklan EH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22191
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22191
MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression.
Liu M, Du Q, Mao G, Dai N, Zhang F
Bioengineered 2022 Mar;13(3):5344-5356
Bioengineered 2022 Mar;13(3):5344-5356
RETRACTED: PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages.
Xu Y, Lu J, Tang Y, Xie W, Zhang H, Wang B, Zhang S, Hou W, Zou C, Jiang P, Zhang W
Cancer letters 2022 Mar 31;529:19-36
Cancer letters 2022 Mar 31;529:19-36
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Zhao K, Huang X, Zhao W, Lu B, Yang Z
Development (Cambridge, England) 2022 Mar 15;149(6)
Development (Cambridge, England) 2022 Mar 15;149(6)
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1.
Yang Q, Wu F, Zhang Y, Wang R
Journal of cellular and molecular medicine 2022 Jul;26(13):3783-3796
Journal of cellular and molecular medicine 2022 Jul;26(13):3783-3796
Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex.
Dong X, Zhang Q, Yu X, Wang D, Ma J, Ma J, Shi SH
Nature neuroscience 2022 Jul;25(7):865-875
Nature neuroscience 2022 Jul;25(7):865-875
Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells.
Shima T, Taniguchi K, Tokumaru Y, Inomata Y, Arima J, Lee SW, Takabe K, Yoshida K, Uchiyama K
Oncology reports 2022 Jan;47(1)
Oncology reports 2022 Jan;47(1)
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Huang L, He C, Zheng S, Wu C, Ren M, Shan Y
Molecular nutrition & food research 2022 Feb;66(3):e2100738
Molecular nutrition & food research 2022 Feb;66(3):e2100738
Metabolic Reprogramming in Response to Alterations of Mitochondrial DNA and Mitochondrial Dysfunction in Gastric Adenocarcinoma.
Chang TC, Lee HT, Pan SC, Cho SH, Cheng C, Ou LH, Lin CI, Lin CS, Wei YH
International journal of molecular sciences 2022 Feb 6;23(3)
International journal of molecular sciences 2022 Feb 6;23(3)
PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis.
He Y, Wang X, Lu W, Zhang D, Huang L, Luo Y, Xiong L, Li H, Zhang P, Li Q, Liang S
Cell death & disease 2022 Feb 4;13(2):118
Cell death & disease 2022 Feb 4;13(2):118
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.
Gao M, Yang Y, Gao Y, Liu T, Guan Q, Zhou T, Shi Y, Hao M, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2022 Feb 25;354:109843
Chemico-biological interactions 2022 Feb 25;354:109843
Cocktail strategy based on a dual function nanoparticle and immune activator for effective tumor suppressive.
Li Q, Chen Q, Yang X, Zhang Y, Lv L, Zhang Z, Zeng S, Lv J, Liu S, Fu B
Journal of nanobiotechnology 2022 Feb 17;20(1):84
Journal of nanobiotechnology 2022 Feb 17;20(1):84
PVT1/miR-145-5p/HK2 modulates vascular smooth muscle cells phenotype switch via glycolysis: The new perspective on the spiral artery remodeling.
Wu M, Liu W, Huang H, Chen Z, Chen Y, Zhong Y, Jin Z, Liu X, Zou L
Placenta 2022 Dec;130:25-33
Placenta 2022 Dec;130:25-33
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Fu J, Yu S, Zhao X, Zhang C, Shen L, Liu Y, Yu H
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
Ge Y, Zhao R, Li B, Xiao B, Zhou L, Zuo S
Experimental cell research 2022 Dec 15;421(2):113377
Experimental cell research 2022 Dec 15;421(2):113377
Long noncoding RNA CERS6-AS1 modulates glucose metabolism and tumor progression in hepatocellular carcinoma by promoting the MDM2/p53 signaling pathway.
Xu B, Wei Y, Liu F, Li L, Zhou S, Peng Y, Li B
Cell death discovery 2022 Aug 4;8(1):348
Cell death discovery 2022 Aug 4;8(1):348
The expression of Hexokinase 2 and its hub genes are correlated with the prognosis in glioma.
Huang Y, Ouyang F, Yang F, Zhang N, Zhao W, Xu H, Yang X
BMC cancer 2022 Aug 18;22(1):900
BMC cancer 2022 Aug 18;22(1):900
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Jia Y, Chen J, Zheng Z, Tao Y, Zhang S, Zou M, Yang Y, Xue M, Hu F, Li Y, Zhang Q, Xue Y, Zheng Z
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Role of Proximal Intestinal Glucose Sensing and Metabolism in the Blood Glucose Control in Type 2 Diabetic Rats After Duodenal Jejunal Bypass Surgery.
Jiang B, Wang H, Li N, Yan Q, Wang W, Wang Y, Xue H, Ma S, Li X, Diao W, Pan R, Gao Z, Qu MH
Obesity surgery 2022 Apr;32(4):1119-1129
Obesity surgery 2022 Apr;32(4):1119-1129
U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells.
Li Y, Chen S, Zhang X, Zhuo N
Bioengineered 2022 Apr;13(4):10200-10212
Bioengineered 2022 Apr;13(4):10200-10212
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586
Cancer letters 2022 Apr 28;532:215586
Disrupting Circadian Rhythm via the PER1-HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer.
Wang J, Huang Q, Hu X, Zhang S, Jiang Y, Yao G, Hu K, Xu X, Liang B, Wu Q, Ma Z, Wang Y, Wang C, Wu Z, Rong X, Liao W, Shi M
Cancer research 2022 Apr 15;82(8):1503-1517
Cancer research 2022 Apr 15;82(8):1503-1517
Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart.
Gu M, Zhou X, Zhu L, Gao Y, Gao L, Bai C, Yang L, Li G
Frontiers in cell and developmental biology 2021;9:774185
Frontiers in cell and developmental biology 2021;9:774185
CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner.
Xu Q, Cheng D, Li G, Liu Y, Li P, Sun W, Ma D, Ni C
International journal of biological sciences 2021;17(9):2294-2307
International journal of biological sciences 2021;17(9):2294-2307
Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.
Chen X, Sun N, Li R, Sang X, Li X, Zhao J, Han J, Yang J, Ikezoe T
International journal of biological sciences 2021;17(5):1263-1276
International journal of biological sciences 2021;17(5):1263-1276
Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2.
Shen J, Xu L, Li Y, Dong W, Cai J, Liu Y, Zhao H, Xu T, Holtz EM, Chang Y, Qiao T, Li K
Frontiers in neuroscience 2021;15:715222
Frontiers in neuroscience 2021;15:715222
Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation.
Zhang Q, Liu Q, Zheng S, Liu T, Yang L, Han X, Lu X
Journal of Cancer 2021;12(16):4830-4840
Journal of Cancer 2021;12(16):4830-4840
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
Chen W, Zhang J, Zhong W, Liu Y, Lu Y, Zeng Z, Huang H, Wan X, Meng X, Zou F, Cai S, Dong H
Frontiers in pharmacology 2021;12:744826
Frontiers in pharmacology 2021;12:744826
BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
Zhong J, Kang Q, Cao Y, He B, Zhao P, Gou Y, Luo Y, He TC, Fan J
American journal of cancer research 2021;11(3):793-811
American journal of cancer research 2021;11(3):793-811
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Sun Q, Yuan M, Wang H, Zhang X, Zhang R, Wang H, Chen X, Zhu M, Liu S, Wu J
Frontiers in oncology 2021;11:767116
Frontiers in oncology 2021;11:767116
Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy.
Qian L, Li Y, Cao Y, Meng G, Peng J, Li H, Wang Y, Xu T, Zhang L, Sun B, Li B, Yu D
Frontiers in oncology 2021;11:689068
Frontiers in oncology 2021;11:689068
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280
European journal of pharmacology 2021 Sep 5;906:174280
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Hasenbilige, Mei J, Dlamini MB, Gao Z, Jiang L, Li Q, Geng C, Shi X, Liu Y, Kong Y, Cao J
Toxicology 2021 Oct;462:152928
Toxicology 2021 Oct;462:152928
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
Xu X, Sun Y, Cen X, Shan B, Zhao Q, Xie T, Wang Z, Hou T, Xue Y, Zhang M, Peng D, Sun Q, Yi C, Najafov A, Xia H
Protein & cell 2021 Oct;12(10):769-787
Protein & cell 2021 Oct;12(10):769-787
MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.
Zhou K, Wei Y, Li X, Yang X
Life sciences 2021 Oct 1;282:119798
Life sciences 2021 Oct 1;282:119798
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
He R, Wang Z, Cui M, Liu S, Wu W, Chen M, Wu Y, Qu Y, Lin H, Chen S, Wang B, Shao Z
Autophagy 2021 Nov;17(11):3338-3360
Autophagy 2021 Nov;17(11):3338-3360
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.
Li R, Li H, Zhu L, Zhang X, Liu D, Li Q, Ni B, Hu L, Zhang Z, Zhang Y, Wang X, Jiang SH
Cell death & disease 2021 Nov 26;12(12):1106
Cell death & disease 2021 Nov 26;12(12):1106
ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling.
Zhu T, Zheng J, Zhuo W, Pan P, Li M, Zhang W, Zhou H, Gao Y, Li X, Liu Z
Cell death discovery 2021 May 29;7(1):126
Cell death discovery 2021 May 29;7(1):126
The novel prognostic risk factor STC2 can regulate the occurrence and progression of osteosarcoma via the glycolytic pathway.
Yu B, Zhang F, Liu L, Liang Y, Tang X, Peng Y, Cai F, Zeng D, Yuan X, Li J, Guo Y, Lv B, Wang M, Liao Q, Lv XB
Biochemical and biophysical research communications 2021 May 21;554:25-32
Biochemical and biophysical research communications 2021 May 21;554:25-32
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
Sun RF, Zhao CY, Chen S, Yu W, Zhou MM, Gao CR
Digestive diseases and sciences 2021 Mar;66(3):802-813
Digestive diseases and sciences 2021 Mar;66(3):802-813
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Shangguan X, He J, Ma Z, Zhang W, Ji Y, Shen K, Yue Z, Li W, Xin Z, Zheng Q, Cao Y, Pan J, Dong B, Cheng J, Wang Q, Xue W
Nature communications 2021 Mar 22;12(1):1812
Nature communications 2021 Mar 22;12(1):1812
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy.
Yang J, Ma S, Xu R, Wei Y, Zhang J, Zuo T, Wang Z, Deng H, Yang N, Shen Q
Journal of controlled release : official journal of the Controlled Release Society 2021 Jun 10;334:21-33
Journal of controlled release : official journal of the Controlled Release Society 2021 Jun 10;334:21-33
Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation.
Ou W, Liang Y, Qin Y, Wu W, Xie M, Zhang Y, Zhang Y, Ji L, Yu H, Li T
Redox biology 2021 Jul;43:101994
Redox biology 2021 Jul;43:101994
Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers.
Yu TJ, Ma D, Liu YY, Xiao Y, Gong Y, Jiang YZ, Shao ZM, Hu X, Di GH
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jul 7;29(7):2350-2365
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jul 7;29(7):2350-2365
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827
EMBO reports 2021 Jan 7;22(1):e50827
An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.
Huang N, Li F, Zhang M, Zhou H, Chen Z, Ma X, Yang L, Wu X, Zhong J, Xiao F, Yang X, Zhao K, Li X, Xia X, Liu Z, Gao S, Zhang N
Cell metabolism 2021 Jan 5;33(1):128-144.e9
Cell metabolism 2021 Jan 5;33(1):128-144.e9
Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease.
Han S, He Z, Jacob C, Hu X, Liang X, Xiao W, Wan L, Xiao P, D'Ascenzo N, Ni J, Liu Q, Xie Q
International journal of molecular sciences 2021 Jan 28;22(3)
International journal of molecular sciences 2021 Jan 28;22(3)
Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer.
Wang Z, Yang Y, Hu S, He J, Wu Z, Qi Z, Huang M, Liu R, Lin Y, Tan C, Xu M, Zhang Z
Cell biology and toxicology 2021 Feb;37(1):35-49
Cell biology and toxicology 2021 Feb;37(1):35-49
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway.
Sun LT, Zhang LY, Shan FY, Shen MH, Ruan SM
Chinese journal of natural medicines 2021 Feb;19(2):143-152
Chinese journal of natural medicines 2021 Feb;19(2):143-152
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
Xu Y, Shi T, Cui X, Yan L, Wang Q, Xu X, Zhao Q, Xu X, Tang QQ, Tang H, Pan D
The EMBO journal 2021 Dec 15;40(24):e108069
The EMBO journal 2021 Dec 15;40(24):e108069
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
Xu Z, Hu H, Fang D, Wang J, Zhao K
The international journal of biochemistry & cell biology 2021 Aug;137:106023
The international journal of biochemistry & cell biology 2021 Aug;137:106023
Mitochondrial Voltage-Dependent Anion Channel 1-Hexokinase-II Complex-Targeted Strategy for Melanoma Inhibition Using Designed Multiblock Peptide Amphiphiles.
Zhang F, Angelova A, Garamus VM, Angelov B, Tu S, Kong L, Zhang X, Li N, Zou A
ACS applied materials & interfaces 2021 Aug 4;13(30):35281-35293
ACS applied materials & interfaces 2021 Aug 4;13(30):35281-35293
An Experimentally Induced Mutation in the UBA Domain of p62 Changes the Sensitivity of Cisplatin by Up-Regulating HK2 Localisation on the Mitochondria and Increasing Mitophagy in A2780 Ovarian Cancer Cells.
Yu S, Yan X, Tian R, Xu L, Zhao Y, Sun L, Su J
International journal of molecular sciences 2021 Apr 13;22(8)
International journal of molecular sciences 2021 Apr 13;22(8)
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
JAK2(V617F) Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.
Li R, Sun N, Chen X, Li X, Zhao J, Cheng W, Hua H, Fukatsu M, Mori H, Takahashi H, Ohkawara H, Fukami M, Okamoto M, Hamazaki Y, Zheng K, Yang J, Ikezoe T
Frontiers in immunology 2020;11:589048
Frontiers in immunology 2020;11:589048
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
Zhang Q, Wang L, Jiang J, Lin S, Luo A, Zhao P, Tan W, Zhang M
Frontiers in immunology 2020;11:2040
Frontiers in immunology 2020;11:2040
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Gao Z, Dlamini MB, Ge H, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Toxicology letters 2020 Oct 1;331:178-187
Toxicology letters 2020 Oct 1;331:178-187
Ginsenoside Rh2 inhibits HeLa cell energy metabolism and induces apoptosis by upregulating voltage‑dependent anion channel 1.
Liu Y, Wang J, Qiao J, Liu S, Wang S, Zhao D, Bai X, Liu M
International journal of molecular medicine 2020 Nov;46(5):1695-1706
International journal of molecular medicine 2020 Nov;46(5):1695-1706
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Sun Z, Zhang Q, Yuan W, Li X, Chen C, Guo Y, Shao B, Dang Q, Zhou Q, Wang Q, Wang G, Liu J, Kan Q
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
Liu R, Deng X, Peng Y, Feng W, Xiong R, Zou Y, Lei X, Zheng X, Xie Z, Tang G
Bioorganic chemistry 2020 Mar;96:103652
Bioorganic chemistry 2020 Mar;96:103652
Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Li M, Shao J, Guo Z, Jin C, Wang L, Wang F, Jia Y, Zhu Z, Zhang Z, Zhang F, Zheng S, Wang X
Journal of cellular and molecular medicine 2020 Mar;24(5):3091-3107
Journal of cellular and molecular medicine 2020 Mar;24(5):3091-3107
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes.
Jiang Y, Gu Y, Xu H, Tian X, Zhang X, Xu X, Yan W, Zhang X
BMC molecular and cell biology 2020 Jun 19;21(1):44
BMC molecular and cell biology 2020 Jun 19;21(1):44
Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.
Butler M, Chotiwan N, Brewster CD, DiLisio JE, Ackart DF, Podell BK, Basaraba RJ, Perera R, Quackenbush SL, Rovnak J
Viruses 2020 Jun 17;12(6)
Viruses 2020 Jun 17;12(6)
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983
Carcinogenesis 2020 Jul 14;41(7):972-983
Quantitative Proteomics Analysis Revealed the Potential Role of lncRNA Ftx in Promoting Gastric Cancer Progression.
Zhu L, Jia R, Zhang J, Li X, Qin C, Zhao Q
Proteomics. Clinical applications 2020 Jan;14(1):e1900053
Proteomics. Clinical applications 2020 Jan;14(1):e1900053
STAT3 Activation-Induced Fatty Acid Oxidation in CD8(+) T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth.
Zhang C, Yue C, Herrmann A, Song J, Egelston C, Wang T, Zhang Z, Li W, Lee H, Aftabizadeh M, Li YJ, Lee PP, Forman S, Somlo G, Chu P, Kruper L, Mortimer J, Hoon DSB, Huang W, Priceman S, Yu H
Cell metabolism 2020 Jan 7;31(1):148-161.e5
Cell metabolism 2020 Jan 7;31(1):148-161.e5
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Feng J, Dai W, Mao Y, Wu L, Li J, Chen K, Yu Q, Kong R, Li S, Zhang J, Ji J, Wu J, Mo W, Xu X, Guo C
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
He X, Li M, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y, Cheng S, Yin H
PLoS biology 2020 Dec;18(12):e3000803
PLoS biology 2020 Dec;18(12):e3000803
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression.
Zhang Y, Zhao L, Yang S, Cen Y, Zhu T, Wang L, Xia L, Liu Y, Zou J, Xu J, Li Y, Cheng X, Lu W, Wang X, Xie X
Journal of experimental & clinical cancer research : CR 2020 Dec 11;39(1):281
Journal of experimental & clinical cancer research : CR 2020 Dec 11;39(1):281
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092
Biochemical pharmacology 2020 Aug;178:114092
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Gu Z, Zhang H, Guo X, Cao Y
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
Up-regulated ANP32E promotes the thyroid carcinoma cell proliferation and migration via activating AKT/mTOR/HK2-mediated glycolysis.
Huang J, Gao W, Liu H, Yin G, Duan H, Huang Z, Zhang Y
Gene 2020 Aug 5;750:144681
Gene 2020 Aug 5;750:144681
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
Modulating the tumor immune microenvironment with sunitinib malate supports the rationale for combined treatment with immunotherapy.
Li W, Zhan M, Quan YY, Wang H, Hua SN, Li Y, Zhang J, Lu L, Cui M
International immunopharmacology 2020 Apr;81:106227
International immunopharmacology 2020 Apr;81:106227
Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer.
Mizuno Y, Hattori K, Taniguchi K, Tanaka K, Uchiyama K, Hirose Y
Oncology letters 2020 Apr;19(4):2934-2942
Oncology letters 2020 Apr;19(4):2934-2942
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression.
Weng ML, Chen WK, Chen XY, Lu H, Sun ZR, Yu Q, Sun PF, Xu YJ, Zhu MM, Jiang N, Zhang J, Zhang JP, Song YL, Ma D, Zhang XP, Miao CH
Nature communications 2020 Apr 20;11(1):1869
Nature communications 2020 Apr 20;11(1):1869
Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2.
Ban D, Hua S, Zhang W, Shen C, Miao X, Liu W
Cellular & molecular biology letters 2019;24:52
Cellular & molecular biology letters 2019;24:52
Fructose 1,6-Bisphosphatase 1 Expression Reduces (18)F-FDG Uptake in Clear Cell Renal Cell Carcinoma.
Chen R, Zhou X, Huang G, Liu J
Contrast media & molecular imaging 2019;2019:9463926
Contrast media & molecular imaging 2019;2019:9463926
Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis.
Ye M, Pang N, Wan T, Huang Y, Wei T, Jiang X, Zhou Y, Huang Y, Yang H, Zhang Z, Yang L
Journal of Cancer 2019;10(3):757-764
Journal of Cancer 2019;10(3):757-764
Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.
Li Y, Xu Q, Yang W, Wu T, Lu X
Gene 2019 Sep 5;712:143956
Gene 2019 Sep 5;712:143956
LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis.
Hua Q, Jin M, Mi B, Xu F, Li T, Zhao L, Liu J, Huang G
Journal of hematology & oncology 2019 Sep 5;12(1):91
Journal of hematology & oncology 2019 Sep 5;12(1):91
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C, Yin T
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Hexokinase 2 dimerization and interaction with voltage-dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer.
Fan K, Fan Z, Cheng H, Huang Q, Yang C, Jin K, Luo G, Yu X, Liu C
Cancer medicine 2019 Oct;8(13):5903-5915
Cancer medicine 2019 Oct;8(13):5903-5915
Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells.
Chen L, Cheng X, Tu W, Qi Z, Li H, Liu F, Yang Y, Zhang Z, Wang Z
Cellular oncology (Dordrecht, Netherlands) 2019 Oct;42(5):679-690
Cellular oncology (Dordrecht, Netherlands) 2019 Oct;42(5):679-690
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer.
Qin Y, Hu Q, Ji S, Xu J, Dai W, Liu W, Xu W, Sun Q, Zhang Z, Ni Q, Yu X, Zhang B, Xu X
Cell proliferation 2019 May;52(3):e12603
Cell proliferation 2019 May;52(3):e12603
Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria.
Yang M, Xu Y, Heisner JS, Sun J, Stowe DF, Kwok WM, Camara AKS
Mitochondrion 2019 May;46:380-392
Mitochondrion 2019 May;46:380-392
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S
Cell death & disease 2019 May 28;10(6):404
Cell death & disease 2019 May 28;10(6):404
Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway.
Wu H, Pan L, Gao C, Xu H, Li Y, Zhang L, Ma L, Meng L, Sun X, Qin H
Molecules (Basel, Switzerland) 2019 May 24;24(10)
Molecules (Basel, Switzerland) 2019 May 24;24(10)
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, Chen J, Mao Y, Wang F, Dai W, Xu L, Wu J, Guo C
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618
Cancer research 2019 May 15;79(10):2604-2618
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
Lian X, Wu X, Li Z, Zhang Y, Song K, Cai G, Li Q, Lin S, Chen X, Bai XY
British journal of pharmacology 2019 Mar;176(5):711-724
British journal of pharmacology 2019 Mar;176(5):711-724
Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer.
Chen J, Yu Y, Li H, Hu Q, Chen X, He Y, Xue C, Ren F, Ren Z, Li J, Liu L, Duan Z, Cui G, Sun R
Molecular cancer 2019 Mar 2;18(1):33
Molecular cancer 2019 Mar 2;18(1):33
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
Hu Q, Qin Y, Ji S, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X, Xu X
Cancer letters 2019 Jun 28;452:226-236
Cancer letters 2019 Jun 28;452:226-236
The long non-coding RNA SNHG1 promotes glioma progression by competitively binding to miR-194 to regulate PHLDA1 expression.
Liu L, Shi Y, Shi J, Wang H, Sheng Y, Jiang Q, Chen H, Li X, Dong J
Cell death & disease 2019 Jun 12;10(6):463
Cell death & disease 2019 Jun 12;10(6):463
Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.
Wang F, Jia Y, Li M, Wang L, Shao J, Guo Q, Tan S, Ding H, Chen A, Zhang F, Zheng S
Cell communication and signaling : CCS 2019 Feb 11;17(1):11
Cell communication and signaling : CCS 2019 Feb 11;17(1):11
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Chai XX, Le YF, Wang JC, Mei CX, Feng JF, Zhao H, Wang C, Lu DZ
Journal of food science 2019 Dec;84(12):3825-3832
Journal of food science 2019 Dec;84(12):3825-3832
Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis.
Song G, Lu Q, Fan H, Zhang X, Ge L, Tian R, Wang S, Feng T, Pan J, Feng J, Xiao Y, Yi X, Ren N, Wang L
Arthritis research & therapy 2019 Apr 3;21(1):87
Arthritis research & therapy 2019 Apr 3;21(1):87
Bufalin inhibits glycolysis-induced cell growth and proliferation through the suppression of Integrin β2/FAK signaling pathway in ovarian cancer.
Li H, Hu S, Pang Y, Li M, Chen L, Liu F, Liu M, Wang Z, Cheng X
American journal of cancer research 2018;8(7):1288-1296
American journal of cancer research 2018;8(7):1288-1296
Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.
Yan B, Cheng L, Jiang Z, Chen K, Zhou C, Sun L, Cao J, Qian W, Li J, Shan T, Lei J, Ma Q, Ma J
Oxidative medicine and cellular longevity 2018;2018:1346958
Oxidative medicine and cellular longevity 2018;2018:1346958
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Yang Y, Cao Y, Chen L, Liu F, Qi Z, Cheng X, Wang Z
Cancer medicine 2018 Sep;7(9):4610-4618
Cancer medicine 2018 Sep;7(9):4610-4618
ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.
Xu Y, Gao W, Zhang Y, Wu S, Liu Y, Deng X, Xie L, Yang J, Yu H, Su J, Sun L
International journal of oncology 2018 Sep;53(3):1055-1068
International journal of oncology 2018 Sep;53(3):1055-1068
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer.
Fan L, Huang C, Li J, Gao T, Lin Z, Yao T
International journal of molecular medicine 2018 Oct;42(4):2247-2259
International journal of molecular medicine 2018 Oct;42(4):2247-2259
Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α.
Yan B, Jiang Z, Cheng L, Chen K, Zhou C, Sun L, Qian W, Li J, Cao J, Xu Q, Ma Q, Lei J
Experimental cell research 2018 Oct 1;371(1):63-71
Experimental cell research 2018 Oct 1;371(1):63-71
Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation.
Li W, Qiu Y, Hao J, Zhao C, Deng X, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Nov;121:156-165
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Nov;121:156-165
Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by (1)H NMR Based Metabolic Profiling.
Xing YX, Li MH, Tao L, Ruan LY, Hong W, Chen C, Zhao WL, Xu H, Chen JF, Wang JS
Journal of proteome research 2018 May 4;17(5):1943-1952
Journal of proteome research 2018 May 4;17(5):1943-1952
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Horita H, Law A, Middleton K
Proteomes 2018 May 22;6(2)
Proteomes 2018 May 22;6(2)
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.
Li Q, Li Y, Liang L, Li J, Luo D, Liu Q, Cai S, Li X
Cell communication and signaling : CCS 2018 Jun 8;16(1):26
Cell communication and signaling : CCS 2018 Jun 8;16(1):26
Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.
Wang S, Li J, Xie J, Liu F, Duan Y, Wu Y, Huang S, He X, Wang Z, Wu X
Oncogene 2018 Jul;37(30):4164-4180
Oncogene 2018 Jul;37(30):4164-4180
MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.
Liu Y, Huo Y, Wang D, Tai Y, Li J, Pang D, Zhang Y, Zhao W, Du N, Huang Y
Biochemical and biophysical research communications 2018 Jul 2;501(4):885-892
Biochemical and biophysical research communications 2018 Jul 2;501(4):885-892
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer.
Xiang J, Hu Q, Qin Y, Ji S, Xu W, Liu W, Shi S, Liang C, Liu J, Meng Q, Liang D, Ni Q, Xu J, Zhang B, Yu X
Cell death & disease 2018 Feb 23;9(3):321
Cell death & disease 2018 Feb 23;9(3):321
Nalmefene attenuates malignant potential in colorectal cancer cell via inhibition of opioid receptor.
Wu Q, Chen X, Wang J, Sun P, Weng M, Chen W, Sun Z, Zhu M, Miao C
Acta biochimica et biophysica Sinica 2018 Feb 1;50(2):156-163
Acta biochimica et biophysica Sinica 2018 Feb 1;50(2):156-163
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
Wu H, He L, Shi J, Hou X, Zhang H, Zhang X, An Q, Fan F
Clinical and experimental pharmacology & physiology 2018 Dec;45(12):1265-1273
Clinical and experimental pharmacology & physiology 2018 Dec;45(12):1265-1273
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.
Lyu Z, Mao Z, Li Q, Xia Y, Liu Y, He Q, Wang Y, Zhao H, Lu Z, Zhou Q
EBioMedicine 2018 Dec;38:178-190
EBioMedicine 2018 Dec;38:178-190
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
Meng Q, Xu J, Liang C, Liu J, Hua J, Zhang Y, Ni Q, Shi S, Yu X
Cell death & disease 2018 Dec 11;9(12):1187
Cell death & disease 2018 Dec 11;9(12):1187
AAED1 modulates proliferation and glycolysis in gastric cancer.
Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y
Oncology reports 2018 Aug;40(2):1156-1164
Oncology reports 2018 Aug;40(2):1156-1164
Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.
Wu L, Cao KX, Ni ZH, Li WD, Chen ZP, Cheng HB, Liu X
Journal of ethnopharmacology 2018 Aug 10;222:71-78
Journal of ethnopharmacology 2018 Aug 10;222:71-78
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Wei WJ, Sun ZK, Shen CT, Song HJ, Zhang XY, Qiu ZL, Luo QY
Theranostics 2017;7(4):987-1001
Theranostics 2017;7(4):987-1001
Dahuang Zhechong Pill Combined with Doxorubicin Induces Cell Death through Regulating Energy Metabolism in Human Hepatocellular Carcinoma Cells.
Wu L, Zhao J, Cai H, Wang J, Chen Z, Li W, Liu X
Evidence-based complementary and alternative medicine : eCAM 2017;2017:6279576
Evidence-based complementary and alternative medicine : eCAM 2017;2017:6279576
Fructose-1,6-Bisphosphatase 1 Reduces (18)F FDG Uptake in Hepatocellular Carcinoma.
Chen R, Li J, Zhou X, Liu J, Huang G
Radiology 2017 Sep;284(3):844-853
Radiology 2017 Sep;284(3):844-853
Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro.
Yao GD, Yang J, Li XX, Song XY, Hayashi T, Tashiro SI, Onodera S, Song SJ, Ikejima T
Acta pharmacologica Sinica 2017 Oct;38(10):1401-1411
Acta pharmacologica Sinica 2017 Oct;38(10):1401-1411
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Ji S, Liu J, Hu P, Liu L, Liu C, Long J, Ni Q, Yu X, Xu J
International journal of oncology 2017 May;50(5):1792-1800
International journal of oncology 2017 May;50(5):1792-1800
CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825
EMBO reports 2017 May;18(5):809-825
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Ni Q, Yu X, Xu J
Cancer letters 2017 Mar 1;388:303-311
Cancer letters 2017 Mar 1;388:303-311
18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma.
Huang P, Zhao X, Xiao W, Dong Y, Hu G
Oncotarget 2017 Jun 13;8(24):39618-39626
Oncotarget 2017 Jun 13;8(24):39618-39626
Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice.
Li J, Chen K, Wang F, Dai W, Li S, Feng J, Wu L, Liu T, Xu S, Xia Y, Lu J, Zhou Y, Xu L, Guo C
Oncotarget 2017 Jul 11;8(28):45965-45980
Oncotarget 2017 Jul 11;8(28):45965-45980
Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.
Shen CT, Wei WJ, Qiu ZL, Song HJ, Zhang XY, Sun ZK, Luo QY
Journal of molecular endocrinology 2017 Jan;58(1):15-23
Journal of molecular endocrinology 2017 Jan;58(1):15-23
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, Liu W
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Gu Z, Zhang H, Li Y, Shen S, Yin X, Zhang W, Cheng R, Zhang Y, Zhang X, Chen H, Huang B, Cao Y
Oncotarget 2017 Dec 26;8(69):114328-114343
Oncotarget 2017 Dec 26;8(69):114328-114343
Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes.
Xu X, Li D, Li X, Shi Q, Ju X
BMC immunology 2017 Dec 19;18(1):51
BMC immunology 2017 Dec 19;18(1):51
Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy.
Li H, Zheng L, Mo Y, Gong Q, Jiang A, Zhao J
PloS one 2016;11(12):e0167908
PloS one 2016;11(12):e0167908
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Wei WJ, Shen CT, Song HJ, Qiu ZL, Luo QY
Oncology reports 2016 Sep;36(3):1576-84
Oncology reports 2016 Sep;36(3):1576-84
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, Shi D
Scientific reports 2016 Mar 9;6:22831
Scientific reports 2016 Mar 9;6:22831
MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer.
Zhou P, Chen WG, Li XW
American journal of cancer research 2015;5(6):2056-63
American journal of cancer research 2015;5(6):2056-63
PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.
Zhuo B, Li Y, Li Z, Qin H, Sun Q, Zhang F, Shen Y, Shi Y, Wang R
Biochemical and biophysical research communications 2015 Aug 21;464(2):401-6
Biochemical and biophysical research communications 2015 Aug 21;464(2):401-6
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44
Cell research 2015 Apr;25(4):429-44
I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT.
Yan S, Zhang Q, Zhong X, Tang J, Wang Y, Yu J, Zhou Y, Zhang J, Guo F, Liu Y, FitzGerald GA, Yu Y
Diabetes 2014 Sep;63(9):2911-23
Diabetes 2014 Sep;63(9):2911-23
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.
Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P, Zhang H
Nature communications 2014 Oct 10;5:5212
Nature communications 2014 Oct 10;5:5212
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 22029-1-AP(HK2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HK2 (IP:22029-1-AP, 3ug; Detection:22029-1-AP 1:1000) with HeLa cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human skeletal muscle using 22029-1-AP(HK2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Hexokinase 2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Hexokinase 2. This antibody recognizes human,mouse,rat antigen. The Hexokinase 2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
