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- References [8]
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- Product number
- 12271-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12271-1-AP, RRID:AB_11182173
- Product name
- UCK1 antibody
- Antibody type
- Polyclonal
- Description
- UCK1 antibody (Cat. #12271-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation.
mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase.
Uridine-Cytidine Kinase 2 (UCK2)/Uridine-Cytidine Kinase Like 1 (UCKL1) complex exacerbates the differentiation of myocardial fibroblasts via TRIM21/Smurf2/Smad3 pathway after myocardial infarction.
PAX3-FOXO1 Drives Targetable Cell State-Dependent Metabolic Vulnerabilities in Rhabdomyosarcoma.
Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells.
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition.
EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.
Adult T-cell leukemia-lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism.
Sha N, Zhou B, Hou G, Xi Z, Wang W, Yan M, He J, Zhou Y, Xia Q, Jiang Y, Zhao Q
Oncogene 2025 May;44(16):1078-1092
Oncogene 2025 May;44(16):1078-1092
mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase.
Pham BQ, Yi SA, Ordureau A, An H
Cell reports 2025 Jan 28;44(1):115179
Cell reports 2025 Jan 28;44(1):115179
Uridine-Cytidine Kinase 2 (UCK2)/Uridine-Cytidine Kinase Like 1 (UCKL1) complex exacerbates the differentiation of myocardial fibroblasts via TRIM21/Smurf2/Smad3 pathway after myocardial infarction.
Zhou X, Zhang Y, Wang H, Qi Z, Gu Z, Cui J, Hu Z, Wang Y
Molecular biomedicine 2025 Dec 29;6(1):151
Molecular biomedicine 2025 Dec 29;6(1):151
PAX3-FOXO1 Drives Targetable Cell State-Dependent Metabolic Vulnerabilities in Rhabdomyosarcoma.
Paras KI, Brunner JS, Montero AM, Boyer JA, Jackson BT, Chakraborty S, Xie A, Guillan K, Siddiquee A, Pajuelo Torres L, Rabinowitz JD, Kung AL, You D, Dela Cruz FS, Finley LWS
Cancer research 2025 Dec 1;85(23):4718-4733
Cancer research 2025 Dec 1;85(23):4718-4733
Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells.
Watanabe T, Yamamoto Y, Kurahashi Y, Kawasoe K, Kidoguchi K, Ureshino H, Kamachi K, Yoshida-Sakai N, Fukuda-Kurahashi Y, Nakamura H, Okada S, Sueoka E, Kimura S
Blood advances 2024 Mar 26;8(6):1345-1358
Blood advances 2024 Mar 26;8(6):1345-1358
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition.
Nam M, Xia W, Mir AH, Jerrett A, Spinelli JB, Huang TT, Possemato R
Nature metabolism 2024 Dec;6(12):2338-2353
Nature metabolism 2024 Dec;6(12):2338-2353
EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.
Yu W, Liang J, Fang T, Jiang J, Zhao R, Li R, Han J, Tian H
Molecular cancer research : MCR 2023 Jul 5;21(7):713-725
Molecular cancer research : MCR 2023 Jul 5;21(7):713-725
Adult T-cell leukemia-lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism.
Yoshida-Sakai N, Watanabe T, Yamamoto Y, Ureshino H, Kamachi K, Kurahashi Y, Fukuda-Kurahashi Y, Kimura S
International journal of cancer 2022 Apr 1;150(7):1184-1197
International journal of cancer 2022 Apr 1;150(7):1184-1197
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Supportive validation
- Submitted by
- Proteintech Group (provider)
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- Experimental details
- The UCK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UCK1. This antibody recognizes human, mouse, rat antigen. The UCK1 antibody has been validated for the following applications: ELISA, WB analysis.
