23374-1-AP

antibody from Proteintech Group

Targeting: ZCCHC8 DKFZp434E2220

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

23374-1-AP

Provider

Proteintech Group

Product name

ZCCHC8 antibody

Antibody type

Polyclonal

Description

KD/KO validated ZCCHC8 antibody (Cat. #23374-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

m(6)A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics.

Wei G, Coker H, Rodermund L, Almeida M, Roach HL, Nesterova TB, Brockdorff N
Nature structural & molecular biology 2025 Nov;32(11):2242-2251

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The NEXT complex regulates H3K27me3 levels to affect cancer progression by degrading G4/U-rich lncRNAs.

Yang Q, Zhou Z, Li L, Lu R, Hou G, Huang C, Huang J, Li H, Zhang Y, Li J, Zhang Y, Xu A, Chen R, Wang Y, Zhao X, Huang J, Wang Y, Zhao X, Yu J
Nucleic acids research 2025 Feb 8;53(4)

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Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses.

Tu S, Zou J, Xiong C, Dai C, Sun H, Luo D, Jin M, Chen H, Zhou H
Journal of virology 2024 Sep 17;98(9):e0079624

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RBMX involves in telomere stability maintenance by regulating TERRA expression.

Liu J, Zheng T, Chen D, Huang J, Zhao Y, Ma W, Liu H
PLoS genetics 2023 Sep;19(9):e1010937

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Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation.

Torre D, Fstkchyan YS, Ho JSY, Cheon Y, Patel RS, Degrace EJ, Mzoughi S, Schwarz M, Mohammed K, Seo JS, Romero-Bueno R, Demircioglu D, Hasson D, Tang W, Mahajani SU, Campisi L, Zheng S, Song WS, Wang YC, Shah H, Francoeur N, Soto J, Salfati Z, Weirauch MT, Warburton P, Beaumont K, Smith ML, Mulder L, Villalta SA, Kessenbrock K, Jang C, Lee D, De Rubeis S, Cobos I, Tam O, Hammell MG, Seldin M, Shi Y, Basu U, Sebastiano V, Byun M, Sebra R, Rosenberg BR, Benner C, Guccione E, Marazzi I
Molecular cell 2023 Dec 7;83(23):4255-4271.e9

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Globally reduced N(6)-methyladenosine (m(6)A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration.

Li Y, Dou X, Liu J, Xiao Y, Zhang Z, Hayes L, Wu R, Fu X, Ye Y, Yang B, Ostrow LW, He C, Sun S
Nature neuroscience 2023 Aug;26(8):1328-1338

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Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2.

Hou L, Wei Y, Lin Y, Wang X, Lai Y, Yin M, Chen Y, Guo X, Wu S, Zhu Y, Yuan J, Tariq M, Li N, Sun H, Wang H, Zhang X, Chen J, Bao X, Jauch R
Nucleic acids research 2020 Apr 17;48(7):3869-3887

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Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells.

Wu Y, Liu W, Chen J, Liu S, Wang M, Yang L, Chen C, Qi M, Xu Y, Qiao Z, Yan R, Kou X, Zhao Y, Shen B, Yin J, Wang H, Gao Y, Gao S
Cell reports 2019 Nov 19;29(8):2461-2472.e6

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mRNAs are sorted for export or degradation before passing through nuclear speckles.

Fan J, Kuai B, Wang K, Wang L, Wang Y, Wu X, Chi B, Li G, Cheng H
Nucleic acids research 2018 Sep 19;46(16):8404-8416