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- References [15]
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- Product number
- 11431-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11431-2-AP, RRID:AB_2185602
- Product name
- SESN3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SESN3 antibody (Cat. #11431-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sestrin1, 2, and 3 are dispensable for female fertility in mice.
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner.
Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats.
Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate.
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.
Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy.
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.
Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation.
Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.
Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.
Wang M, Chen W, Zeng X, Wang T, Sun Y, Yang Q
Journal of ovarian research 2024 Feb 1;17(1):28
Journal of ovarian research 2024 Feb 1;17(1):28
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner.
Liu S, Li H, Zhang Y, Song H, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166792
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166792
Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats.
Taiwo RO, Sandouka S, Saadi A, Kovac S, Shekh-Ahmad T
Neuropharmacology 2023 Nov 1;238:109670
Neuropharmacology 2023 Nov 1;238:109670
Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate.
Maheshwari M, Yadav N, Hasanain M, Pandey P, Sahai R, Choyal K, Singh A, Nengroo MA, Saini KK, Kumar D, Mitra K, Datta D, Sarkar J
Cell death & disease 2022 Dec 15;13(12):1045
Cell death & disease 2022 Dec 15;13(12):1045
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Wang T, Hu W, Niu Y, Liu S, Fu L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
Jang SK, Hong SE, Lee DH, Kim JY, Kim JY, Ye SK, Hong J, Park IC, Jin HO
BMC cancer 2021 Jul 12;21(1):803
BMC cancer 2021 Jul 12;21(1):803
FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.
Lee KI, Choi S, Matsuzaki T, Alvarez-Garcia O, Olmer M, Grogan SP, D'Lima DD, Lotz MK
Proceedings of the National Academy of Sciences of the United States of America 2020 Feb 11;117(6):3135-3143
Proceedings of the National Academy of Sciences of the United States of America 2020 Feb 11;117(6):3135-3143
Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy.
Tu J, Li W, Li S, Liu W, Zhang Y, Wu X, Luo R, Hua W, Wang K, Song Y, Kang L, Yang W, Yang S, Yang C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(5):1940-1954
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(5):1940-1954
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Wang T, Niu Y, Liu S, Yuan H, Liu X, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3368-3377
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3368-3377
Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.
Huang LG, Zou J, Lu QC
Brain research 2018 Jun 15;1689:109-122
Brain research 2018 Jun 15;1689:109-122
Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation.
Nogueira V, Patra KC, Hay N
eLife 2018 Apr 24;7
eLife 2018 Apr 24;7
Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.
Shen T, Alvarez-Garcia O, Li Y, Olmer M, Lotz MK
Osteoarthritis and cartilage 2017 Feb;25(2):287-296
Osteoarthritis and cartilage 2017 Feb;25(2):287-296
Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC
PloS one 2013;8(11):e78780
PloS one 2013;8(11):e78780
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N
Developmental cell 2010 Apr 20;18(4):592-604
Developmental cell 2010 Apr 20;18(4):592-604
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SESN3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SESN3. This antibody recognizes human,mouse,rat antigen. The SESN3 antibody has been validated for the following applications: ELISA, WB analysis.
