MAML2

gene product
KIAA1819, MAM3
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
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259 antibodies from 26 providers.

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Novus Biologicals
34 antibodies
antibodies-online
101 antibodies
NSJ Bioreagents
2 antibodies
Cell Signaling Technology, Inc
2 antibodies
GeneTex
2 antibodies
NovoPro Bioscience Inc.
2 antibodies
Cusabio Biotech Co., Ltd
4 antibodies
Bethyl Laboratories
3 antibodies
LifeSpan BioSciences, Inc.
44 antibodies
OriGene
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Abnova Corporation
4 antibodies
Invitrogen Antibodies
4 antibodies
Biorbyt
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Boster Biological Technology
2 antibodies
Abgent
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Atlas Antibodies
1 antibody
Aviva Systems Biology
1 antibody
Creative Biolabs
7 antibodies
Creative Diagnostics
3 antibodies
Leading Biology
3 antibodies
St John's Laboratory
1 antibody
United States Biological
8 antibodies
MilliporeSigma / Merck KGaA
1 antibody
MyBioSource
1 antibody