abx011430

antibody from Abbexa

Targeting: RSPO1 FLJ40906, RSPONDIN

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

abx011430

Provider

Abbexa

Product name

R-Spondin 1 (RSPO1) Antibody

Antibody type

Monoclonal

Description

R-Spondin 1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF beta pathway. Has a essential roles in ovary determination.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.