abx011430

RSPO1 antibody from Abbexa
FLJ40906, RSPONDIN
Western blot
Recommended by provider
ELISA
Recommended by provider

Antibody data

Product number
abx011430
Provider
Abbexa
Product name
R-Spondin 1 (RSPO1) Antibody
Provider product page
Abbexa - abx011430
Antibody type
Monoclonal
Description
R-Spondin 1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF beta pathway. Has a essential roles in ovary determination.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µl
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Provider Type Product Number
- No reagents -