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- Antigen structure
- References [9]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 18003-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18003-1-AP, RRID:AB_2299845
- Product name
- DNA Polymerase Beta antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DNA Polymerase Beta antibody (Cat. #18003-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability.
CDK-independent role of D-type cyclins in regulating DNA mismatch repair.
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE).
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription.
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.
Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M
bioRxiv : the preprint server for biology 2024 Jan 13;
bioRxiv : the preprint server for biology 2024 Jan 13;
CDK-independent role of D-type cyclins in regulating DNA mismatch repair.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M
Molecular cell 2024 Apr 4;84(7):1224-1242.e13
Molecular cell 2024 Apr 4;84(7):1224-1242.e13
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair.
Nguyen DD, Kim E, Le NT, Ding X, Jaiswal RK, Kostlan RJ, Nguyen TNT, Shiva O, Le MT, Chai W
Science advances 2023 May 10;9(19):eadd8023
Science advances 2023 May 10;9(19):eadd8023
Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE).
Schaich MA, Schnable BL, Kumar N, Roginskaya V, Jakielski RC, Urban R, Zhong Z, Kad NM, Van Houten B
Nucleic acids research 2023 Apr 24;51(7):e39
Nucleic acids research 2023 Apr 24;51(7):e39
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, Gao FH, Xia L, Yang L, Liu LG, Wang WW, Liu CX, Tong Y, Wu YZ, Zheng JK, Chen GQ, Zhou L, Wu YL
Nature communications 2021 Jan 4;12(1):51
Nature communications 2021 Jan 4;12(1):51
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.
Eckelmann BJ, Bacolla A, Wang H, Ye Z, Guerrero EN, Jiang W, El-Zein R, Hegde ML, Tomkinson AE, Tainer JA, Mitra S
NAR cancer 2020 Sep;2(3):zcaa013
NAR cancer 2020 Sep;2(3):zcaa013
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription.
Sengupta S, Wang H, Yang C, Szczesny B, Hegde ML, Mitra S
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep 8;117(36):22183-22192
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep 8;117(36):22183-22192
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.
Sengupta S, Yang C, Hegde ML, Hegde PM, Mitra J, Pandey A, Dutta A, Datarwala AT, Bhakat KK, Mitra S
DNA repair 2018 Jun-Jul;66-67:1-10
DNA repair 2018 Jun-Jul;66-67:1-10
Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines.
Wang Y, Chen X, Sun Q, Zang W, Li M, Dong Z, Zhao G
Cancer cell international 2016;16:85
Cancer cell international 2016;16:85
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 18003-1-AP(POLB antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DNA polymerase beta antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DNA polymerase beta. This antibody recognizes human,mouse,rat antigen. The DNA polymerase beta antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 18003-1-AP(POLB antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
