Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 18003-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18003-1-AP, RRID:AB_2299845
- Product name
- DNA Polymerase Beta antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DNA Polymerase Beta antibody (Cat. #18003-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription.
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.
Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines.
Lei H, Xu HZ, Shan HZ, Liu M, Lu Y, Fang ZX, Jin J, Jing B, Xiao XH, Gao SM, Gao FH, Xia L, Yang L, Liu LG, Wang WW, Liu CX, Tong Y, Wu YZ, Zheng JK, Chen GQ, Zhou L, Wu YL
Nature communications 2021 Jan 4;12(1):51
Nature communications 2021 Jan 4;12(1):51
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.
Eckelmann BJ, Bacolla A, Wang H, Ye Z, Guerrero EN, Jiang W, El-Zein R, Hegde ML, Tomkinson AE, Tainer JA, Mitra S
NAR cancer 2020 Sep;2(3):zcaa013
NAR cancer 2020 Sep;2(3):zcaa013
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription.
Sengupta S, Wang H, Yang C, Szczesny B, Hegde ML, Mitra S
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep 8;117(36):22183-22192
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep 8;117(36):22183-22192
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.
Sengupta S, Yang C, Hegde ML, Hegde PM, Mitra J, Pandey A, Dutta A, Datarwala AT, Bhakat KK, Mitra S
DNA repair 2018 Jun - Jul;66-67:1-10
DNA repair 2018 Jun - Jul;66-67:1-10
Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines.
Wang Y, Chen X, Sun Q, Zang W, Li M, Dong Z, Zhao G
Cancer cell international 2016;16:85
Cancer cell international 2016;16:85
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 18003-1-AP(POLB antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DNA polymerase beta antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DNA polymerase beta. This antibody recognizes human,mouse,rat antigen. The DNA polymerase beta antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 18003-1-AP(POLB antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue