TMEM123

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

Description

Transmembrane protein 123

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus, Vesicles, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11 (102396332 - 102470384)

Ensembl ID

ENSG00000152558  (ver. 103.38)

Orthologs

Mouse Tmem123: ENSMUSG00000050912

UniProt

Q8N131

neXtProt

NX_Q8N131

Human splice variants
Mouse splice variants

Protein structure