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- References [17]
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- Immunohistochemistry [1]
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- Product number
- 10581-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10581-1-AP, RRID:AB_2284057
- Product name
- POT1 antibody
- Antibody type
- Polyclonal
- Description
- POT1 antibody (Cat. #10581-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence.
TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres.
The evolving genetic landscape of telomere biology disorder dyskeratosis congenita.
Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia.
TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres.
Telomere Attrition in Induced Pluripotent Stem Cell-Derived Neurons From ALS/FTD-Related C9ORF72 Repeat Expansion Carriers.
Vascular senescence in progeria: role of endothelial dysfunction.
C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation.
Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening.
SIRT6 enhances telomerase activity to protect against DNA damage and senescence in hypertrophic ligamentum flavum cells from lumbar spinal stenosis patients.
The spatiotemporal expression of TERT and telomere repeat binding proteins in the postnatal mouse testes.
The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse.
Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation.
Concomitant underexpression of TGFBR2 and overexpression of hTERT are associated with poor prognosis in cervical cancer.
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells.
CGGBP1 phosphorylation constitutes a telomere-protection signal.
Evidence for multiple forms and modifications of human POT1.
Chen L, Zhang C, Ge Y, Zhou H, Yang S, Wei W, Zhou Q, Xiao K, Huang G, Li X, Wang J, Zheng J, Gu R, Ju Z, Wu S
Aging cell 2026 Jan;25(1):e70347
Aging cell 2026 Jan;25(1):e70347
TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres.
Janovič T, Perez GI, Boelting G, Schmidt JC
Cell reports 2025 Sep 23;44(9):116178
Cell reports 2025 Sep 23;44(9):116178
The evolving genetic landscape of telomere biology disorder dyskeratosis congenita.
Tummala H, Walne AJ, Badat M, Patel M, Walne AM, Alnajar J, Chow CC, Albursan I, Frost JM, Ballard D, Killick S, Szitányi P, Kelly AM, Raghavan M, Powell C, Raymakers R, Todd T, Mantadakis E, Polychronopoulou S, Pontikos N, Liao T, Madapura P, Hossain U, Vulliamy T, Dokal I
EMBO molecular medicine 2024 Oct;16(10):2560-2582
EMBO molecular medicine 2024 Oct;16(10):2560-2582
Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia.
Stuart A, de Lange T
bioRxiv : the preprint server for biology 2024 Jun 26;
bioRxiv : the preprint server for biology 2024 Jun 26;
TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres.
Janovič T, Perez GI, Schmidt JC
bioRxiv : the preprint server for biology 2024 Dec 23;
bioRxiv : the preprint server for biology 2024 Dec 23;
Telomere Attrition in Induced Pluripotent Stem Cell-Derived Neurons From ALS/FTD-Related C9ORF72 Repeat Expansion Carriers.
Robinson H, Ali SI, Diaz-Hernandez ME, Lopez-Gonzalez R
Frontiers in cell and developmental biology 2022;10:874323
Frontiers in cell and developmental biology 2022;10:874323
Vascular senescence in progeria: role of endothelial dysfunction.
Xu Q, Mojiri A, Boulahouache L, Morales E, Walther BK, Cooke JP
European heart journal open 2022 Jul;2(4):oeac047
European heart journal open 2022 Jul;2(4):oeac047
C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation.
Koranne R, Brown K, Vandenbroek H, Taylor WR
Experimental cell research 2022 Apr 15;413(2):113063
Experimental cell research 2022 Apr 15;413(2):113063
Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening.
Uysal F, Kosebent EG, Toru HS, Ozturk S
Journal of assisted reproduction and genetics 2021 Feb;38(2):429-441
Journal of assisted reproduction and genetics 2021 Feb;38(2):429-441
SIRT6 enhances telomerase activity to protect against DNA damage and senescence in hypertrophic ligamentum flavum cells from lumbar spinal stenosis patients.
Chen J, Liu Z, Wang H, Qian L, Li Z, Song Q, Zhong G
Aging 2021 Feb 10;13(4):6025-6040
Aging 2021 Feb 10;13(4):6025-6040
The spatiotemporal expression of TERT and telomere repeat binding proteins in the postnatal mouse testes.
Kosebent EG, Ozturk S
Andrologia 2021 Apr;53(3):e13976
Andrologia 2021 Apr;53(3):e13976
The altered expression of telomerase components and telomere-linked proteins may associate with ovarian aging in mouse.
Kosebent EG, Uysal F, Ozturk S
Experimental gerontology 2020 Sep;138:110975
Experimental gerontology 2020 Sep;138:110975
Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation.
Assani G, Yessoufou A, Xiong Y, Segbo J, Yu X, Zhou F, Zhou Y
Asian Pacific journal of cancer prevention : APJCP 2019 Jun 1;20(6):1849-1856
Asian Pacific journal of cancer prevention : APJCP 2019 Jun 1;20(6):1849-1856
Concomitant underexpression of TGFBR2 and overexpression of hTERT are associated with poor prognosis in cervical cancer.
Yang H, Zhang H, Zhong Y, Wang Q, Yang L, Kang H, Gao X, Yu H, Xie C, Zhou F, Zhou Y
Scientific reports 2017 Feb 14;7:41670
Scientific reports 2017 Feb 14;7:41670
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells.
Yang H, Wu L, Ke S, Wang W, Yang L, Gao X, Fang H, Yu H, Zhong Y, Xie C, Zhou F, Zhou Y
Journal of Cancer 2016;7(9):1152-62
Journal of Cancer 2016;7(9):1152-62
CGGBP1 phosphorylation constitutes a telomere-protection signal.
Singh U, Maturi V, Jones RE, Paulsson Y, Baird DM, Westermark B
Cell cycle (Georgetown, Tex.) 2014;13(1):96-105
Cell cycle (Georgetown, Tex.) 2014;13(1):96-105
Evidence for multiple forms and modifications of human POT1.
Singh U, Maturi V, Westermark B
DNA repair 2013 Nov;12(11):876-7
DNA repair 2013 Nov;12(11):876-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10581-1-AP(POT1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The POT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human POT1. This antibody recognizes human, mouse antigen. The POT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
