Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 14063-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SETD8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SETD8 antibody (Cat. #14063-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SETD8 inhibits ferroptosis in pancreatic cancer by inhibiting the expression of RRAD.
SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair.
The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy.
SETD8 cooperates with MZF1 to participate in hyperglycemia-induced endothelial inflammation via elevation of WNT5A levels in diabetic nephropathy.
SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas.
c-Myc participates in high glucose-mediated endothelial inflammation via upregulation of IRAK1 expression in diabetic nephropathy.
KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy.
SET8 mitigates hepatic ischemia/reperfusion injury in mice by suppressing MARK4/NLRP3 inflammasome pathway.
The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.
ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.
DDB2 regulates DNA replication through PCNA-independent degradation of CDT2.
SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.
SETD8 induces stemness and epithelial-mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression.
SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN.
Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.
SET8 participates in lipopolysaccharide-mediated BV2 cell inflammation via modulation of TICAM-2 expression.
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression.
Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity.
SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells.
Lu Z, Hu Q, Qin Y, Yang H, Xiao B, Chen W, Ji S, Zu G, Wang Z, Fan G, Xu X, Chen X
Cancer cell international 2023 Mar 18;23(1):50
Cancer cell international 2023 Mar 18;23(1):50
SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair.
Wang X, Cao C, Tan X, Liao X, Du X, Wang X, Liu T, Gong D, Hu Z, Tian X
Cell & bioscience 2023 Jun 12;13(1):107
Cell & bioscience 2023 Jun 12;13(1):107
The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy.
Li X, Lu L, Hou W, Wang F, Huang T, Meng Z, Zhu M
Journal of translational medicine 2022 Mar 29;20(1):147
Journal of translational medicine 2022 Mar 29;20(1):147
SETD8 cooperates with MZF1 to participate in hyperglycemia-induced endothelial inflammation via elevation of WNT5A levels in diabetic nephropathy.
Wang F, Hou W, Li X, Lu L, Huang T, Zhu M, Miao C
Cellular & molecular biology letters 2022 Mar 26;27(1):30
Cellular & molecular biology letters 2022 Mar 26;27(1):30
SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas.
Pan D, Du YR, Li R, Shen AH, Liu XD, Li CY, Hu BR
Biomedical and environmental sciences : BES 2022 Mar 20;35(3):194-205
Biomedical and environmental sciences : BES 2022 Mar 20;35(3):194-205
c-Myc participates in high glucose-mediated endothelial inflammation via upregulation of IRAK1 expression in diabetic nephropathy.
Hou W, Lu L, Li X, Sun M, Zhu M, Miao C
Cellular signalling 2022 Apr;92:110263
Cellular signalling 2022 Apr;92:110263
KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy.
Lu L, Li X, Zhong Z, Zhou W, Zhou D, Zhu M, Miao C
International journal of biological sciences 2021;17(15):4093-4107
International journal of biological sciences 2021;17(15):4093-4107
SET8 mitigates hepatic ischemia/reperfusion injury in mice by suppressing MARK4/NLRP3 inflammasome pathway.
Luo Y, Huang Z, Mou T, Pu J, Li T, Li Z, Yang H, Yan P, Wu Z, Wu Q
Life sciences 2021 May 15;273:119286
Life sciences 2021 May 15;273:119286
The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.
Huang T, Li X, Wang F, Lu L, Hou W, Zhu M, Miao C
Cell death & disease 2021 Mar 29;12(4):333
Cell death & disease 2021 Mar 29;12(4):333
ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.
Lu L, Zhong Z, Gu J, Nan K, Zhu M, Miao C
Molecular medicine (Cambridge, Mass.) 2021 Jul 8;27(1):74
Molecular medicine (Cambridge, Mass.) 2021 Jul 8;27(1):74
DDB2 regulates DNA replication through PCNA-independent degradation of CDT2.
Wu X, Yu M, Zhang Z, Leng F, Ma Y, Xie N, Lu F
Cell & bioscience 2021 Feb 8;11(1):34
Cell & bioscience 2021 Feb 8;11(1):34
SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.
Liu M, Qin Y, Hu Q, Liu W, Ji S, Xu W, Fan G, Ye Z, Zhang Z, Xu X, Yu X, Zhuo Q
Cancer letters 2021 Feb 28;499:265-278
Cancer letters 2021 Feb 28;499:265-278
SETD8 induces stemness and epithelial-mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression.
Liu M, Shi Y, Hu Q, Qin Y, Ji S, Liu W, Zhuo Q, Fan G, Ye Z, Song C, Yu X, Xu X, Xu W
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1614-1624
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1614-1624
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression.
Qi J, Wu Q, Cheng Q, Chen X, Zhu M, Miao C
Journal of diabetes research 2020;2020:2308520
Journal of diabetes research 2020;2020:2308520
SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN.
Shen X, Chen X, Wang J, Liu J, Wang Z, Hua Q, Wu Q, Su Y, He H, Hu Y, Meng Z, Xiong W, Zhu M
Experimental & molecular medicine 2020 Oct;52(10):1715-1729
Experimental & molecular medicine 2020 Oct;52(10):1715-1729
Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.
Wen Z, Zhu H, Zhang A, Lin J, Zhang G, Liu D, Xiao Y, Ye C, Sun D, Wu B, Zhang J, Gao J
Experimental cell research 2020 Oct 1;395(1):112178
Experimental cell research 2020 Oct 1;395(1):112178
SET8 participates in lipopolysaccharide-mediated BV2 cell inflammation via modulation of TICAM-2 expression.
Zhao Y, Yang X, Meng F, Li W
Canadian journal of physiology and pharmacology 2020 Nov;98(11):818-825
Canadian journal of physiology and pharmacology 2020 Nov;98(11):818-825
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression.
Wang J, Shen X, Liu J, Chen W, Wu F, Wu W, Meng Z, Zhu M, Miao C
Cell death & disease 2020 May 21;11(5):383
Cell death & disease 2020 May 21;11(5):383
Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity.
Li Z, Liu H, Niu Z, Zhong W, Xue M, Wang J, Yang F, Zhou Y, Zhou Y, Xu T, Hou J
Molecular & cellular proteomics : MCP 2018 Nov;17(11):2119-2131
Molecular & cellular proteomics : MCP 2018 Nov;17(11):2119-2131
SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells.
Chen X, Wu Q, Jiang H, Wang J, Zhao Y, Xu Y, Zhu M
Acta biochimica et biophysica Sinica 2018 Jul 1;50(7):635-642
Acta biochimica et biophysica Sinica 2018 Jul 1;50(7):635-642
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The SETD8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SETD8. This antibody recognizes human, mouse antigen. The SETD8 antibody has been validated for the following applications: ELISA, WB analysis.