14063-1-AP

antibody from Proteintech Group

Targeting: KMT5A PR-Set7, SET07, SET8, SETD8

Provider product page for 14063-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [29]
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Validations
Western blot [1]

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Product number: 14063-1-AP - Provider product page
Provider: Proteintech Group
Product name: SETD8 antibody
Antibody type: Polyclonal
Description: KD/KO validated SETD8 antibody (Cat. #14063-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

KMT5A protein structure - 14063-1-AP shown in red.

Submitted references NAT10 regulates heart development and function by maintaining the expression of genes related to fatty acid β-oxidation and heart contraction.

Shi L, Zhang M, Yang H, Li X, He S, Chu Y, Gao M, Zhang Z, Zhang JZ, Li Z, Chen Z
Cell death and differentiation 2026 Feb;33(2):358-373

Discovery of a Potent, Selective, and In Vivo Efficacious Covalent Inhibitor for Lysine Methyltransferase SETD8.

Chen H, Dutta RP, Li Z, Zhong Y, Ma A, Park KS, Kottur J, Park A, Babault N, Wang K, Wang D, Xiong Y, Kaniskan HÜ, Luo M, Parekh S, Jin J
Journal of medicinal chemistry 2026 Feb 26;69(4):4255-4269

Discovery of KMT5A repressed miR-99b cluster with potential to restore chemotherapy sensitivity in gastric cancer by regulating mitochondrial complex II and affecting OXPHOS.

Niu L, Kang X, Zheng J, Wu F, Liu S, Hong L, Liu H, Wang J, Fan D, Nie Y, Chen Z
Pharmacological research 2025 Nov;221:107996

Shexiang Baoxin Pill alleviates atherosclerosis by inhibiting macrophage-mediated inflammation via suppressing KMT5A mediated Irf7 transcription.

Cheng S, Luo W, Zhang Z, Li J, Li X, Wang Y, Weng X, Dong Z
Journal of ethnopharmacology 2025 May 28;348:119833

Comprehensive machine learning-based integration develops a novel prognostic model for glioblastoma.

Jiang Q, Yang X, Deng T, Yan J, Guo F, Mo L, An S, Huang Q
Molecular therapy. Oncology 2024 Sep 19;32(3):200838

Loss of NAT10 Reduces the Translation of Kmt5a mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure.

Xu T, Du T, Zhuang X, He X, Yan Y, Wu J, Zhou H, Li Y, Liao X, He J, Liu C, Dong Y, Ou J, Lin S, Chen D, Huang ZP
Journal of the American Heart Association 2024 Oct 15;13(20):e035714

Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer.

Peng X, Ma L, Chen X, Tang F, Zong X
Oncology reports 2024 Aug;52(2)

SETD8 inhibits ferroptosis in pancreatic cancer by inhibiting the expression of RRAD.

Lu Z, Hu Q, Qin Y, Yang H, Xiao B, Chen W, Ji S, Zu G, Wang Z, Fan G, Xu X, Chen X
Cancer cell international 2023 Mar 18;23(1):50

SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair.

Wang X, Cao C, Tan X, Liao X, Du X, Wang X, Liu T, Gong D, Hu Z, Tian X
Cell & bioscience 2023 Jun 12;13(1):107

The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy.

Li X, Lu L, Hou W, Wang F, Huang T, Meng Z, Zhu M
Journal of translational medicine 2022 Mar 29;20(1):147

SETD8 cooperates with MZF1 to participate in hyperglycemia-induced endothelial inflammation via elevation of WNT5A levels in diabetic nephropathy.

Wang F, Hou W, Li X, Lu L, Huang T, Zhu M, Miao C
Cellular & molecular biology letters 2022 Mar 26;27(1):30

SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas.

Pan D, Du YR, Li R, Shen AH, Liu XD, Li CY, Hu BR
Biomedical and environmental sciences : BES 2022 Mar 20;35(3):194-205

c-Myc participates in high glucose-mediated endothelial inflammation via upregulation of IRAK1 expression in diabetic nephropathy.

Hou W, Lu L, Li X, Sun M, Zhu M, Miao C
Cellular signalling 2022 Apr;92:110263

KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy.

Lu L, Li X, Zhong Z, Zhou W, Zhou D, Zhu M, Miao C
International journal of biological sciences 2021;17(15):4093-4107

SET8 mitigates hepatic ischemia/reperfusion injury in mice by suppressing MARK4/NLRP3 inflammasome pathway.

Luo Y, Huang Z, Mou T, Pu J, Li T, Li Z, Yang H, Yan P, Wu Z, Wu Q
Life sciences 2021 May 15;273:119286

The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.

Huang T, Li X, Wang F, Lu L, Hou W, Zhu M, Miao C
Cell death & disease 2021 Mar 29;12(4):333

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.

Lu L, Zhong Z, Gu J, Nan K, Zhu M, Miao C
Molecular medicine (Cambridge, Mass.) 2021 Jul 8;27(1):74

DDB2 regulates DNA replication through PCNA-independent degradation of CDT2.

Wu X, Yu M, Zhang Z, Leng F, Ma Y, Xie N, Lu F
Cell & bioscience 2021 Feb 8;11(1):34

SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.

Liu M, Qin Y, Hu Q, Liu W, Ji S, Xu W, Fan G, Ye Z, Zhang Z, Xu X, Yu X, Zhuo Q
Cancer letters 2021 Feb 28;499:265-278

SETD8 induces stemness and epithelial-mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression.

Liu M, Shi Y, Hu Q, Qin Y, Ji S, Liu W, Zhuo Q, Fan G, Ye Z, Song C, Yu X, Xu X, Xu W
Acta biochimica et biophysica Sinica 2021 Dec 8;53(12):1614-1624

Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.

Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089

High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression.

Qi J, Wu Q, Cheng Q, Chen X, Zhu M, Miao C
Journal of diabetes research 2020;2020:2308520

SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN.

Shen X, Chen X, Wang J, Liu J, Wang Z, Hua Q, Wu Q, Su Y, He H, Hu Y, Meng Z, Xiong W, Zhu M
Experimental & molecular medicine 2020 Oct;52(10):1715-1729

Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.

Wen Z, Zhu H, Zhang A, Lin J, Zhang G, Liu D, Xiao Y, Ye C, Sun D, Wu B, Zhang J, Gao J
Experimental cell research 2020 Oct 1;395(1):112178

SET8 participates in lipopolysaccharide-mediated BV2 cell inflammation via modulation of TICAM-2 expression.

Zhao Y, Yang X, Meng F, Li W
Canadian journal of physiology and pharmacology 2020 Nov;98(11):818-825

High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.

Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516

High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression.

Wang J, Shen X, Liu J, Chen W, Wu F, Wu W, Meng Z, Zhu M, Miao C
Cell death & disease 2020 May 21;11(5):383

Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity.

Li Z, Liu H, Niu Z, Zhong W, Xue M, Wang J, Yang F, Zhou Y, Zhou Y, Xu T, Hou J
Molecular & cellular proteomics : MCP 2018 Nov;17(11):2119-2131

SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells.

Chen X, Wu Q, Jiang H, Wang J, Zhao Y, Xu Y, Zhu M
Acta biochimica et biophysica Sinica 2018 Jul 1;50(7):635-642

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SETD8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SETD8. This antibody recognizes human, mouse antigen. The SETD8 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14063-1-AP.pdf

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