BS7521

antibody from Bioworld Technology, Inc
Targeting: KMT5A PR-Set7, SET07, SET8, SETD8
Provider product page for BS7521
Western blot
Immunohistochemistry

Antibody data

Product number
BS7521 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SETD8 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SETD8.
Description
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specificallymonomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tagfor epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role inthe silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance ofproper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis.Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382',leading to repress p53/TP53-target genes.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
KMT5A protein structure - BS7521 shown in red.