16417-1-AP

antibody from Proteintech Group

Targeting: BCAT2 BCAM, BCT2

Provider product page for 16417-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 16417-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16417-1-AP, RRID:AB_10792411
Product name: BCAT2 antibody
Antibody type: Polyclonal
Description: KD/KO validated BCAT2 antibody (Cat. #16417-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

BCAT2 protein structure - 16417-1-AP shown in red.

Submitted references A spatiotemporal proteomic map of human adipogenesis.

Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor AJ, Couchet M, Ribicic S, Wabitsch M, Messias AC, Iuso A, Müller TD, Rydén M, Mejhert N, Krahmer N
Nature metabolism 2024 May;6(5):861-879

Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy.

Mora S, Adegoke OAJ
American journal of physiology. Cell physiology 2024 Mar 1;326(3):C866-C879

Interior decorative volatile organic compounds exposure induces sleep disorders through aberrant branched chain amino acid transaminase 2 mediated glutamatergic signaling resulting from a neuroinflammatory cascade.

Zheng J, Wu M, Pang Y, Liu Q, Liu Y, Jin X, Tang J, Bao L, Niu Y, Zheng Y, Zhang R
The Science of the total environment 2024 Jul 15;934:173254

Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype.

Liang Y, Pan C, Yin T, Wang L, Gao X, Wang E, Quang H, Huang D, Tan L, Xiang K, Wang Y, Alexander PB, Li QJ, Yao TP, Zhang Z, Wang XF
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2303489

Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes.

Nishi K, Yoshii A, Abell L, Zhou B, Frausto R, Ritterhoff J, McMillen TS, Sweet I, Wang Y, Gao C, Tian R
Cell reports 2023 Jun 27;42(6):112641

The duration of glucocorticoid treatment alters the anabolic response to high-force muscle contractions.

Dunlap KR, Steiner JL, Hickner RC, Chase PB, Gordon BS
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Jul 1;135(1):183-195

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.

Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, Pokharel SP, Gao M, Chen M, Shen C, Tan B, Small A, Wang K, Zhang Z, Qin X, Yang L, Wunderlich M, Zhang B, Mulloy JC, Marcucci G, Chen CW, Wei M, Su R, Chen J, Deng X
Cell stem cell 2023 Jan 5;30(1):52-68.e13

Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts.

Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Sato T, Kuno A, Fujita Y, Ino S, Shimizu M, Toda Y, Ohwada W, Yano T, Tanno M, Miki T, Miura T
Physiological reports 2023 Feb;11(4):e15608

Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression.

Yang D, Liu H, Cai Y, Lu K, Zhong X, Xing S, Song W, Zhang Y, Ye L, Zhu X, Wang T, Zhang P, Li ST, Feng J, Jia W, Zhang H, Gao P
Cell reports 2022 Nov 22;41(8):111691

Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.

Fu F, Lai Q, Hu J, Zhang L, Zhu X, Kou J, Yu B, Li F
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)

Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma.

Zhang B, Peng H, Zhou M, Bao L, Wang C, Cai F, Zhang H, Wang JE, Niu Y, Chen Y, Wang Y, Hatanpaa KJ, Copland JA, DeBerardinis RJ, Wang Y, Luo W
Cancer research 2022 Jul 5;82(13):2388-2402

BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16.

Ma QX, Zhu WY, Lu XC, Jiang D, Xu F, Li JT, Zhang L, Wu YL, Chen ZJ, Yin M, Huang HY, Lei QY
Nature metabolism 2022 Jan;4(1):106-122

3,6-dichlorobenzo[b]thiophene-2-carboxylic acid alleviates ulcerative colitis by suppressing mammalian target of rapamycin complex 1 activation and regulating intestinal microbiota.

He QZ, Wei P, Zhang JZ, Liu TT, Shi KQ, Liu HH, Zhang JW, Liu SJ
World journal of gastroenterology 2022 Dec 14;28(46):6522-6536

Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice.

Yang Y, Zhao M, He X, Wu Q, Li DL, Zang WJ
Frontiers in pharmacology 2021;12:647481

Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats.

Shida Y, Endo H, Owada S, Inagaki Y, Sumiyoshi H, Kamiya A, Eto T, Tatemichi M
Scientific reports 2021 Nov 29;11(1):23104

Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma.

Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W
Cellular and molecular life sciences : CMLS 2021 Jan;78(1):195-206

Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1.

Lai Q, Yuan G, Shen L, Zhang L, Fu F, Liu Z, Zhang Y, Kou J, Liu S, Yu B, Li F
Basic research in cardiology 2021 Jan 23;116(1):3

Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.

Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X
Diabetes 2020 Jul;69(7):1355-1367

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.

Li JT, Yin M, Wang D, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY
Nature cell biology 2020 Feb;22(2):167-174

Glucose promotes cell growth by suppressing branched-chain amino acid degradation.

Shao D, Villet O, Zhang Z, Choi SW, Yan J, Ritterhoff J, Gu H, Djukovic D, Christodoulou D, Kolwicz SC Jr, Raftery D, Tian R
Nature communications 2018 Jul 26;9(1):2935

Metabolic effects of acute thiamine depletion are reversed by rapamycin in breast and leukemia cells.

Liu S, Miriyala S, Keaton MA, Jordan CT, Wiedl C, Clair DK, Moscow JA
PloS one 2014;9(1):e85702

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse kidney tissue were subjected to SDS PAGE followed by western blot with 16417-1-AP(BCAT2 antibody) at dilution of 1:800
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The BCAT2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BCAT2. This antibody recognizes human,mouse,rat antigen. The BCAT2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 16417-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skin using 16417-1-AP(BCAT2 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue